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https://www.readbyqxmd.com/read/29321645/mri-features-predictive-of-negative-surgical-margins-in-patients-with-her2-overexpressing-breast-cancer-undergoing-breast-conservation
#1
Brittany Z Dashevsky, Jung Hun Oh, Aditya P Apte, Blanca Bernard-Davila, Elizabeth A Morris, Joseph O Deasy, Elizabeth J Sutton
Here we develop a tool to predict resectability of HER2+ breast cancer at breast conservation surgery (BCS) utilizing features identified on preoperative breast MRI. We identified patients with HER2+ breast cancer who obtained pre-operative breast MRI and underwent BCS between 2002-2013. From the contoured tumor on pre-operative MRI, shape, histogram, and co-occurrence and size zone matrix texture features were extracted. In univariate analysis, Spearman's correlation coefficient (Rs) was used to assess the correlation between each image feature and an endpoint (surgical re-excision)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314345/differentiation-between-vasogenic-edema-and-infiltrative-tumor-in-patients-with-high-grade-gliomas-using-texture-patch-based-analysis
#2
Moran Artzi, Gilad Liberman, Deborah T Blumenthal, Orna Aizenstein, Felix Bokstein, Dafna Ben Bashat
BACKGROUND: High-grade gliomas (HGGs) induce both vasogenic edema and extensive infiltration of tumor cells, both of which present with similar appearance on conventional MRI. Using current radiological criteria, differentiation between these tumoral and nontumoral areas within the nonenhancing lesion area remains challenging. PURPOSE: To use radiomics patch-based analysis, based on conventional MRI, for the classification of the nonenhancing lesion area in patients with HGG into tumoral and nontumoral components...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29312866/quantitative-texture-analysis-on-pre-treatment-computed-tomography-predicts-local-recurrence-in-stage-i-non-small-cell-lung-cancer-following-stereotactic-radiation-therapy
#3
Carole Dennie, Rebecca Thornhill, Carolina A Souza, Cecilia Odonkor, Jason R Pantarotto, Robert MacRae, Graham Cook
Background: The prediction of local recurrence (LR) of stage I non-small cell lung cancer (NSCLC) after definitive stereotactic body radiotherapy (SBRT) remains elusive. The purpose of this study was to assess whether quantitative imaging features on pre-treatment computed tomography (CT) can predict LR beyond 18 (18F) fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT maximum standard uptake value (SUVmax). Methods: This retrospective study evaluated 36 patients with 37 stage I NSCLC who had local tumor control (LC; n=19) and (LR; n=18)...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29311707/associations-of-tumor-pd-1-ligands-immunohistochemical-studies-and-textural-features-in-18f-fdg-pet-in-squamous-cell-carcinoma-of-the-head-and-neck
#4
Rui-Yun Chen, Ying-Chun Lin, Wei-Chih Shen, Te-Chun Hsieh, Kuo-Yang Yen, Shang-Wen Chen, Chia-Hung Kao
To know tumor PD-L1 expression through IHC or the FDG-PET related radiomics, we investigated the association between programmed cell death protein 1 ligand (PD-L1) expression and immunohistochemical (IHC) biomarkers or textural features of 18F-fluoro-2-deoxdeoxyglucose positron emission tomography (18F-FDG PET) in 53 oropharyngeal or hypopharyngeal cancer patients who were ready to undergo radiotherapy-based treatment. Differences in textural features or biomarkers between tumors with and without PD-L1 expression were tested using a Mann-Whitney U test...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311558/radiogenomic-analysis-of-hypoxia-pathway-is-predictive-of-overall-survival-in-glioblastoma
#5
Niha Beig, Jay Patel, Prateek Prasanna, Virginia Hill, Amit Gupta, Ramon Correa, Kaustav Bera, Salendra Singh, Sasan Partovi, Vinay Varadan, Manmeet Ahluwalia, Anant Madabhushi, Pallavi Tiwari
Hypoxia, a characteristic trait of Glioblastoma (GBM), is known to cause resistance to chemo-radiation treatment and is linked with poor survival. There is hence an urgent need to non-invasively characterize tumor hypoxia to improve GBM management. We hypothesized that (a) radiomic texture descriptors can capture tumor heterogeneity manifested as a result of molecular variations in tumor hypoxia, on routine treatment naïve MRI, and (b) these imaging based texture surrogate markers of hypoxia can discriminate GBM patients as short-term (STS), mid-term (MTS), and long-term survivors (LTS)...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311419/radiogenomics-of-hepatocellular-carcinoma-multiregion-analysis-based-identification-of-prognostic-imaging-biomarkers-by-integrating-gene-data-a-preliminary-study
#6
Wei Xia, Ying Chen, Rui Zhang, Zhuangzhi Yan, Xiaobo Zhou, Bo Zhang, Xin Gao
To identify prognostic imaging biomarkers for hepatocellular carcinoma (HCC) in contrast-enhanced computed tomography (CECT) with biological interpretations by associating imaging features and gene modules. We retrospectively analyzed 371 patients who had gene expression profiles. For the 38 patients with CECT imaging data, automatic intra-tumor partition was performed resulting in three spatially distinct subregions. We extracted totally 37 quantitative imaging features describing intensity, geometry, and texture from each subregion...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29307077/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-thymic-tumors-correlation-with-grading-and-staging
#7
Angelo Iannarelli, Beatrice Sacconi, Francesca Tomei, Marco Anile, Flavia Longo, Mario Bezzi, Alessandro Napoli, Luca Saba, Michele Anzidei, Giulia D'Ovidio, Roberto Scipione, Carlo Catalano
OBJECTIVES: To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors. MATERIALS AND METHODS: Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded...
January 6, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29301932/a-post-reconstruction-harmonization-method-for-multicenter-radiomic-studies-in-pet
#8
Fanny Orlhac, Sarah Boughdad, Cathy Philippe, Hugo Stalla-Bourdillon, Christophe Nioche, Laurence Champion, Michaël Soussan, Frédérique Frouin, Vincent Frouin, Irène Buvat
Introduction: Several reports have shown that radiomic feature values are affected by the acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method to standardize features measured from Positron Emission Tomography (PET) images obtained using different imaging protocols to remove the center effect while preserving patient-specific effects. Methods: Pre-treatment 18F-FDG-PET images of patients with breast cancer were included. In Department A, 63 patients were scanned using a Gemini Time-Of-Flight-PET/Computed-Tomography scanner including 16 triple-negative lesions (TN)...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29298305/response-monitoring-of-breast-cancer-patients-receiving-neoadjuvant-chemotherapy-using-quantitative-ultrasound-texture-and-molecular-features
#9
Lakshmanan Sannachi, Mehrdad Gangeh, Hadi Tadayyon, Ali Sadeghi-Naini, Sonal Gandhi, Frances C Wright, Elzbieta Slodkowska, Belinda Curpen, William Tran, Gregory J Czarnota
BACKGROUND: Pathological response of breast cancer to chemotherapy is a prognostic indicator for long-term disease free and overall survival. Responses of locally advanced breast cancer in the neoadjuvant chemotherapy (NAC) settings are often variable, and the prediction of response is imperfect. The purpose of this study was to detect primary tumor responses early after the start of neoadjuvant chemotherapy using quantitative ultrasound (QUS), textural analysis and molecular features in patients with locally advanced breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29284425/mri-texture-analysis-in-differentiating-luminal-a-and-luminal-b-breast-cancer-molecular-subtypes-a-feasibility-study
#10
Kirsi Holli-Helenius, Annukka Salminen, Irina Rinta-Kiikka, Ilkka Koskivuo, Nina Brück, Pia Boström, Riitta Parkkola
BACKGROUND: The aim of this study was to use texture analysis (TA) of breast magnetic resonance (MR) images to assist in differentiating estrogen receptor (ER) positive breast cancer molecular subtypes. METHODS: Twenty-seven patients with histopathologically proven invasive ductal breast cancer were selected in preliminary study. Tumors were classified into molecular subtypes: luminal A (ER-positive and/or progesterone receptor (PR)-positive, human epidermal growth factor receptor type 2 (HER2) -negative, proliferation marker Ki-67 < 20 and low grade (I)) and luminal B (ER-positive and/or PR-positive, HER2-positive or HER2-negative with high Ki-67 ≥ 20 and higher grade (II or III))...
December 29, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/29273964/hrct-texture-analysis-for-pure-or-part-solid-ground-glass-nodules-distinguishability-of-adenocarcinoma-in-situ-or-minimally-invasive-adenocarcinoma-from-invasive-adenocarcinoma
#11
Takuya Yagi, Motohiko Yamazaki, Riuko Ohashi, Rei Ogawa, Hiroyuki Ishikawa, Norihiko Yoshimura, Masanori Tsuchida, Yoichi Ajioka, Hidefumi Aoyama
PURPOSE: To distinguish between adenocarcinoma in situ (AIS)-minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) showing pure or part-solid ground-glass nodules (GGNs) by high-resolution computed tomography (HRCT) texture analysis. MATERIALS AND METHODS: This retrospective study included 101 consecutive patients with 115 pure or part-solid GGNs ≤ 3 cm diameter, which were surgically resected and pathologically diagnosed with AIS, MIA, or IAC (48 AIS-MIA and 67 IAC) between April 2011 and March 2015...
December 22, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29251666/advanced-pet-imaging-in-oncology-status-and-developments-with-current-and-future-relevance-to-lung-cancer-care
#12
Wieland Voigt
PURPOSE OF REVIEW: This review highlights the status and developments of PET imaging in oncology, with particular emphasis on lung cancer. We discuss the significance of PET for diagnosis, staging, decision-making, monitoring of treatment response, and drug development. The PET key advantage, the noninvasive assessment of functional and molecular tumor characteristics including tumor heterogeneity, as well as PET trends relevant to cancer care are exemplified. RECENT FINDINGS: Advances of PET and radiotracer technology are encouraging for multiple fields of oncological research and clinical application, including in-depth assessment of PET images by texture analysis (radiomics)...
December 14, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29247171/computer-aided-nodule-assessment-and-risk-yield-canary-may-facilitate-non-invasive-prediction-of-egfr-mutation-status-in-lung-adenocarcinomas
#13
Ryan Clay, Benjamin R Kipp, Sarah Jenkins, Ron A Karwoski, Fabien Maldonado, Srinivasan Rajagopalan, Jesse S Voss, Brian J Bartholmai, Marie Christine Aubry, Tobias Peikert
Computer-Aided Nodule Assessment and Risk Yield (CANARY) is quantitative imaging analysis software that predicts the histopathological classification and post-treatment disease-free survival of patients with adenocarcinoma of the lung. CANARY characterizes nodules by the distribution of nine color-coded texture-based exemplars. We hypothesize that quantitative computed tomography (CT) analysis of the tumor and tumor-free surrounding lung facilitates non-invasive identification of clinically-relevant mutations in lung adenocarcinoma...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239394/quantitative-mr-image-analysis-for-brian-tumor
#14
Zeina A Shboul, Sayed M S Reza, Khan M Iftekharuddin
This paper presents an integrated quantitative MR image analysis framework to include all necessary steps such as MRI inhomogeneity correction, feature extraction, multiclass feature selection and multimodality abnormal brain tissue segmentation respectively. We first obtain mathematical algorithm to compute a novel Generalized multifractional Brownian motion (GmBm) texture feature. We then demonstrate efficacy of multiple multiresolution texture features including regular fractal dimension (FD) texture, and stochastic texture such as multifractional Brownian motion (mBm) and GmBm features for robust tumor and other abnormal tissue segmentation in brain MRI...
2018: VipIMAGE 2017 (2017)
https://www.readbyqxmd.com/read/29226824/mdixon-based-texture-analysis-of-an-intraosseous-lipoma-a-case-report-and-current-review-for-the-dental-clinician
#15
Kyung Mi Lee, Hyug-Gi Kim, Yeon-Hee Lee, Eui Jong Kim
An intraosseous lipoma is a rare histologic variant of lipoma, accounting for only 0.1% of all primary bone tumors. This may not be the actual incidence because most of these lesions are frequently asymptomatic, but imaging modalities, such as computed tomography or magnetic resonance imaging (MRI) seem to have increased the detection rate. Lipoma occasionally undergoes osseous metaplasia and becomes an osseous lipoma. Although there are numerous papers discussing intraosseous lipoma and some authors have tried to differentiate lipomas from osseous lipomas, there is still a great deal of confusion with regard to characteristic radiologic features and the use of terms...
December 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29222685/prediction-of-outcome-using-pretreatment-18f-fdg-pet-ct-and-mri-radiomics-in-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#16
François Lucia, Dimitris Visvikis, Marie-Charlotte Desseroit, Omar Miranda, Jean-Pierre Malhaire, Philippe Robin, Olivier Pradier, Mathieu Hatt, Ulrike Schick
PURPOSE: The aim of this study is to determine if radiomics features from 18fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) images could contribute to prognoses in cervical cancer. METHODS: One hundred and two patients (69 for training and 33 for testing) with locally advanced cervical cancer (LACC) receiving chemoradiotherapy (CRT) from 08/2010 to 12/2016 were enrolled in this study. 18F-FDG PET/CT and MRI examination [T1, T2, T1C, diffusion-weighted imaging (DWI)] were performed for each patient before CRT...
December 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29221270/analysis-of-the-clinical-differentiation-of-pulmonary-sclerosing-pneumocytoma-and-lung-cancer
#17
Jun Zhu
Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign lung tumor. This study investigated the diagnostic experience of PSP and lung cancer. Methods: This study is a retrospective study. We observed the locations of lung lesions, imaging form and clinical symptoms, and recorded the surgical complications through comparing patients with PSP and lung cancer. Results: From December 2012 to February 2017, 187 PSP cases and 197 lung cancer cases were collected...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220731/quantitative-texture-analysis-in-the-prediction-of-idh-status-in-low-grade-gliomas
#18
Asgeir Store Jakola, Yi-Hua Zhang, Anne J Skjulsvik, Ole Solheim, Hans Kristian Bø, Erik Magnus Berntsen, Ingerid Reinertsen, Sasha Gulati, Petter Förander, Torkel B Brismar
OBJECTIVES: Molecular markers provide valuable information about treatment response and prognosis in patients with low-grade gliomas (LGG). In order to make this important information available prior to surgery the aim of this study was to explore if molecular status in LGG can be discriminated by preoperative magnetic resonance imaging (MRI). PATIENTS AND METHODS: All patients with histopathologically confirmed LGG with available molecular status who had undergone a preoperative standard clinical MRI protocol using a 3T Siemens Skyra scanner during 2008-2015 were retrospectively identified...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29220213/clinical-application-of-biparametric-mri-texture-analysis-for-detection-and-evaluation-of-high-grade-prostate-cancer-in-zone-specific-regions
#19
Xiang-Ke Niu, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng, Xin Li
OBJECTIVE: The purpose of this study was to investigate the performance of biparametric MRI texture analysis (TA) in detecting and evaluating high-grade prostate cancer in zone-specific regions. MATERIALS AND METHODS: A retrospective study included 184 consecutively registered biopsy-naive patients in whom prostate cancer was suspected who were undergoing multiparametric prostate MRI. MR images were scored and evaluated by two readers using the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and biparametric MRI TA in separate sessions...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29219225/dce-mri-texture-analysis-with-tumor-subregion-partitioning-for-predicting-ki-67-status-of-estrogen-receptor-positive-breast-cancers
#20
Ming Fan, Hu Cheng, Peng Zhang, Xin Gao, Juan Zhang, Guoliang Shao, Lihua Li
BACKGROUND: Breast tumor heterogeneity is related to risk factors that lead to worse prognosis, yet such heterogeneity has not been well studied. PURPOSE: To predict the Ki-67 status of estrogen receptor (ER)-positive breast cancer patients via analysis of tumor heterogeneity with subgroup identification based on patterns of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). STUDY TYPE: Retrospective study. POPULATION: Seventy-seven breast cancer patients with ER-positive breast cancer were investigated, of whom 51 had low Ki-67 expression...
December 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
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