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https://www.readbyqxmd.com/read/29141813/the-neutrophil-to-lymphocyte-ratio-as-disease-actvity-marker-in-multiple-sclerosis-and-optic-neuritis
#1
A K Bisgaard, G Pihl-Jensen, J L Frederiksen
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The neutrophil-to-lymphocyte ratio (NLR) has been identified as a disease activity marker in several diseases. We aim to evaluate the significance of the NLR in the different subtypes of MS, optic neuritis (ON) and in relation to disease activity and Expanded Disability Status Scale (EDSS). METHODS: We included 378 patients and 813 healthy controls (HC) from The Nordic Reference Interval Project 2000 (NORIP)...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29121642/limbic-system-damage-in-ms-mri-assessment-and-correlations-with-clinical-testing
#2
Jie Wen, Dmitriy A Yablonskiy, Amber Salter, Anne H Cross
Volume loss in some limbic region structures has been observed in multiple sclerosis (MS) patients. However, in vivo evaluation of existing tissue cellular microstructure integrity has received less attention. The goal of studies reported here was to quantitatively assess loss of limbic system volumes and tissue integrity, and to evaluate associations of these measures with cognitive and physical dysfunction in MS patients. Thirty-one healthy controls (HC) and 80 MS patients, including 32 relapsing remitting (RRMS), 32 secondary progressive (SPMS) and 16 primary progressive (PPMS), participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29102453/timing-of-conduction-abnormalities-leading-to-permanent-pacemaker-insertion-after-transcatheter-aortic-valve-implantation-a-single-centre-review
#3
Daniel Ozier, Nevena Zivkovic, Gabby Elbaz-Greener, Sheldon M Singh, Harindra C Wijeysundera
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is the preferred alternative to traditional surgical aortic valve replacement; however, it remains expensive. One potential driver of cost is the need for postprocedural monitoring for conduction abnormalities after TAVI. Given the paucity of literature on the optimal length of monitoring, we aimed to determine when clinically significant conduction abnormalities leading to permanent pacemaker (PPM) insertion after TAVI were first identified...
September 1, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29098964/misdiagnosis-of-graves-hyperthyroidism-due-to-therapeutic-biotin-intervention
#4
Yentl De Roeck, Eva Philipse, Theodorus B Twickler, Luc Van Gaal
BACKGROUND: Lately, high dose of biotin is often given orally to patients with a primary progressive multiple sclerosis (PPMS). However, the molecule biotin is also a principle compound in various analytic immunoassays. CLINICAL CASE: An asymptomatic 60-year-old woman with PPMS on high dose of biotin therapy (3 × 100 mg/d) displayed abnormal thyroid function tests (TSH 0.02 mU/l, fT4 > 103 pmol/l, and fT3 > 46 pmol/l). TSH was determined by a homogeneous sandwich chemiluminescent immunoassay and fT4 and fT3 were both determined by a homogeneous, sequential, chemiluminescent immunoassay...
November 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29055465/radiologically-isolated-syndrome-and-multiple-sclerosis
#5
REVIEW
B Yamout, M Al Khawajah
BACKGROUND: Incidental white matter lesions (WML) are increasingly seen on brain magnetic resonance imaging (MRI) in clinical practice. Demyelination consistent with MS is seen in 0.1-0.7% of the population as evident by autopsy and MRI studies. The term radiologically isolated syndrome (RIS) was coined to define a subgroup of patients with demyelinating lesions highly suggestive of multiple sclerosis (MS). The Okuda criteria for diagnosing RIS help in stratifying the risk of conversion to MS but RIS is still not considered a distinct MS phenotype...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29041866/-progressive-ms-macro-views-the-need-for-novel-clinical-trial-paradigms-to-enable-drug-development-for-progressive-ms
#6
P Zaratin, G Comi, D Leppert
This article outlines the principal challenges to establish a standard phase-2 approach for progressive multiple sclerosis (PMS) and presents referring strategies to accelerate the registration process via a guidance approved by regulatory agencies. Accordingly, the contribution of 'big datasets' for a better understanding of the natural history of primary-progressive multiple sclerosis (PPMS) and secondary-progressive multiple sclerosis (SPMS) and of their prognostic factors and the value of novel biomarkers are discussed...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29033561/specific-iga-against-pseudomonas-aeruginosa-in-severe-copd
#7
Laura Millares, Sara Martí, Carmen Ardanuy, Josefina Liñares, Salud Santos, Jordi Dorca, Marian García-Nuñez, Sara Quero, Eduard Monsó
BACKGROUND: The bronchial mucosa is protected by a specialized immune system focused on the prevention of colonization and infection by potentially pathogenic microorganisms (PPMs). Immunoglobulin A (IgA) is the principal antibody involved in this mechanism. A defective immune barrier may facilitate the recurrent presence of PPMs in COPD. PURPOSE: The aim of this study was to determine IgA-mediated bronchial specific immune responses against Pseudomonas aeruginosa in stable patients with severe disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29024167/imaging-spinal-cord-atrophy-in-progressive-myelopathies-htlv-i-associated-neurological-disease-ham-tsp-and-multiple-sclerosis-ms
#8
Shila Azodi, Govind Nair, Yoshimi Enose-Akahata, Emily Charlip, Ashley Vellucci, Irene Cortese, Jenifer Dwyer, B Jeanne Billioux, Chevaz Thomas, Joan Ohayon, Daniel S Reich, Steven Jacobson
OBJECTIVE: Previous work measures spinal cord thinning in chronic progressive myelopathies, including human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). Quantitative measurements of spinal cord atrophy are important in fully characterizing these and other spinal cord diseases. We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers. METHODS: Spinal cord cross-sectional area was measured in individuals (24 healthy controls [HCs], 17 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS], 17 secondary progressive MS [SPMS], and 40 primary progressive MS [PPMS]) from C1 to T10...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28963581/pacemaker-implantation-after-tavi-predictors-of-av-block-persistence
#9
Luise Gaede, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Johannes Sperzel, Johannes Blumenstein, Alexander Berkowitsch, Thomas Walther, Christian Hamm, Albrecht Elsässer, Holger Nef, Helge Möllmann
AIMS: Approximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. METHODS AND RESULTS: Between 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM (n = 173) 14...
September 29, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28893499/influence-of-pretreatment-techniques-on-anaerobic-digestion-of-pulp-and-paper-mill-sludge-a-review
#10
REVIEW
C Veluchamy, Ajay S Kalamdhad
Pulp and paper industry is one of the most polluting, energy and water intensive industries in the world. Produced pulp and paper mill sludge (PPMS) faces a major problem for handling and its management. An anaerobic digestion has become an alternative source. This review provides a detailed summary of anaerobic digestion of PPMS - An overview of the developments and improvement opportunities. This paper explores the different pretreatment methods to enhance biogas production from the PPMS. First, the paper gives an overview of PPMS production, and then it reviews PPMS as a substrate for anaerobic digestion with or without pretreatment...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28890199/distinct-cognitive-impairments-in-different-disease-courses-of-multiple-sclerosis-a-systematic-review-and-meta-analysis
#11
REVIEW
Andreas Johnen, Nils C Landmeyer, Paul-Christian Bürkner, Heinz Wiendl, Sven G Meuth, Heinz Holling
Cognitive impairment (CI) is common and debilitating in patients with multiple sclerosis. However, little is known about how different disease courses affect CI, impeding prognosis and disease management. Here, we contrasted the magnitude and profile of CI measured with standardized neuropsychological tests in patients with primary progressive multiple sclerosis (PPMS) against relapsing-remitting multiple sclerosis (RRMS) while considering potentially confounding demographic and clinical differences. Systematic literature review and meta-analysis was performed finding 47 eligible studies (N=4460 patients)...
September 8, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28870573/cxcl10-and-cxcl13-chemokines-in-patients-with-relapsing-remitting-and-primary-progressive-multiple-sclerosis
#12
Piotr Iwanowski, Jacek Losy, Lucyna Kramer, Marlena Wójcicka, Elżbieta Kaufman
OBJECTIVES: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system characterized by a variable clinical course. Different pathogenic mechanisms responsible for relapsing remitting (RRMS) and primary progressive multiple sclerosis (PPMS) are modulated by immunological process with important role of chemokine network. CXCL10 and CXCL13 chemokines act as chemoattractants and modulators of proinflammatory reactions promoting process of demyelination...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28852678/the-risk-of-cardiac-device-related-infection-in-bacteremic-patients-is-species-specific-results-of-a-12-year-prospective-cohort
#13
Stacey A Maskarinec, Joshua T Thaden, Derek D Cyr, Felicia Ruffin, Maria Souli, Vance G Fowler
BACKGROUND: The species-specific risk of cardiac device-related infection (CDRI) among bacteremic patients is incompletely understood. METHODS: We conducted a prospective cohort study of hospitalized patients from October 2002 to December 2014 with a cardiac device (CD) and either Staphylococcus aureus bacteremia (SAB) or Gram-negative bacteremia (GNB). Cardiac devices were defined as either prosthetic heart valves (PHVs), including valvular support rings, permanent pacemakers (PPMs)/automatic implantable cardioverter defibrillators (AICDs), or left ventricular assist devices (LVADs)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28834803/embedding-a-professional-practice-model-across-a-system
#14
Jennifer S Mensik, Deborah Maust Martin, Karen L Johnson, Carla M Clark, Christina M Trifanoff
Professional practice models (PPMs) are an integral part of any organization on the Magnet® journey, whether initial designation or redesignation. Through the journey, the PPM should become embedded within the nursing culture. Leadership at multiple levels is crucial to ensure successful adoption and implementation.
September 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28797088/csf-profile-in-primary-progressive-multiple-sclerosis-re-exploring-the-basics
#15
Ahmed Abdelhak, Tilman Hottenrott, Christoph Mayer, Gudrun Hintereder, Uwe K Zettl, Oliver Stich, Hayrettin Tumani
OBJECTIVE: The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS). METHODS: The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28794971/the-relationship-between-cortical-lesions-and-periventricular-nawm-abnormalities-suggests-a-shared-mechanism-of-injury-in-primary-progressive-ms
#16
Matteo Pardini, Maria Petracca, Asaff Harel, Lazar Fleysher, Niels Oesingmann, Giulia Bommarito, Michelle Fabian, Declan Chard, Fred Lublin, Matilde Inglese
In subjects with multiple sclerosis (MS), pathology is more frequent near the inner and outer surfaces of the brain. Here, we sought to explore if in subjects with primary progressive MS (PPMS) cortical lesion load is selectively associated with the severity of periventricular normal appearing white matter (NAWM) damage, as assessed with diffusion weighted imaging. To this aim, twenty-four subjects with PPMS and twenty healthy controls were included in the study. Using diffusion data, skeletonized mean diffusivity (MD) NAWM maps were computed excluding WM lesions and a 2 mm-thick peri-lesional rim...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28777826/cerebrospinal-fluid-b-cells-and-disease-progression-in-multiple-sclerosis-a-longitudinal-prospective-study
#17
Sebastian Wurth, Bettina Kuenz, Gabriel Bsteh, Rainer Ehling, Franziska Di Pauli, Harald Hegen, Michael Auer, Viktoria Gredler, Florian Deisenhammer, Markus Reindl, Thomas Berger
BACKGROUND: There is evidence that B cells play an important role in disease pathology of multiple sclerosis (MS). The aim of this prospective observational study was to determine the predictive value of cerebrospinal fluid (CSF) B cell subtypes in disease evolution of patients with MS. MATERIALS AND METHODS: 128 patients were included between 2004 and 2012. Median follow up time was 7.9 years (range 3.3-10.8 years). 10 patients were lost to follow-up. 32 clinically isolated syndrome- (CIS), 25 relapsing remitting MS- (RRMS), 2 secondary progressive MS- (SPMS) and 9 primary progressive MS- (PPMS) patients were included...
2017: PloS One
https://www.readbyqxmd.com/read/28747241/developing-a-predictive-model-for-the-energy-content-of-goat-milk-as-the-basis-for-a-functional-unit-formulation-to-be-used-in-the-life-cycle-assessment-of-dairy-goat-production-systems
#18
P P Danieli, B Ronchi
Recent reports on livestock environmental impact based on life cycle assessment (LCA) did not fully consider the case of the dairy goat. Assignment of an environmental impact (e.g. global warming potential) to a specific product needs to be related to the appropriate 'unitary amount' or functional unit (FU). For milk, the energy content may provide a common basis for a definition of the FU. To date, no ad hoc formulations for the FU of goat milk have been proposed. For these reasons, this study aimed to develop and test one or more predictive models (DPMs) for the gross energy (GE) content of goat milk, based on published compositional data, such as fat (F), protein, total solids (TS), solid non-fat matter (SNF), lactose (Lac) and ash...
July 27, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28733766/magnetic-resonance-imaging-in-patients-with-cardiac-implantable-electronic-devices-a-single-center-prospective-study
#19
Mrinal Yadava, Matthew Nugent, Angela Krebsbach, Jessica Minnier, Peter Jessel, Charles A Henrikson
PURPOSE: Cardiac implantable electronic devices (CIEDs) have traditionally been a contraindication for magnetic resonance imaging (MRI). Recent studies suggest that MRI can be conducted safely in select patients with pacemakers (PPMs) and implantable cardioverter defibrillators (ICDs). We sought to determine the safety of MRI in patients with CIEDs, using a protocol for patient selection and device programming. METHODS: This is a prospective, single-center study...
July 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28722216/primary-pulmonary-myxoid-sarcoma-located-in-interlobar-fissure-without-parenchymal-invasion
#20
Seok Kim, Sang Yun Song, Ju Sik Yun, Yoo Duk Choi, Kook Joo Na
Primary pulmonary myxoid sarcoma (PPMS), classified as low to intermediate grade malignant myxoid endobronchial tumor, is rarely reported. Most reported cases occurred in lung parenchyme with an endobronchial component. Herein, we report a case of PPMS in a 29-year-old woman that developed in a major fissure of the left lung without parenchymal invasion. Histopathologically, the diagnosis was compatible to PPMS with EWSR1-CREB1 translocation.
September 2017: Thoracic Cancer
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