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https://www.readbyqxmd.com/read/29349966/-a-medium-term-therapeutic-effects-of-anatomic-locking-plate-for-femoral-intertrochanteric-with-lateral-femoral-wall-fractures
#1
Jin-Wei Xu, Lei Han, Yun-Gen Hu, Wei-Li Fang, Bo Ji
OBJECTIVE: To retrospectively study medium term follow-up outcomes of the femoral intertrochanteric with lateral femoral wall fractures using anatomic locking plate fixation. METHODS: From June 2010 to January 2013, 18 cases of the unstable femoral intertrochanteric with lateral femoral wall fractures were treated with the anatomic locking plate, included 8 males and 10 females with an average age of 75.5 years ranging from 19 to 83 years old. There were 8 cases of traffic accident injuries, 6 cases of falls injuries, and 4 cases of falling from high place...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29340726/prognostic-prediction-models-for-resection-of-large-hepatocellular-carcinoma-a-korean-multicenter-study
#2
Shin Hwang, Jae-Won Joh, Hee Jung Wang, Dong Goo Kim, Kyung Sik Kim, Kyung-Suk Suh, Seong Hoon Kim, Hee Chul Yu, Chol Kyoon Cho, Young-Joo Lee, Ki-Hun Kim, Jong Man Kim, Bong-Wan Kim, Sung-Gyu Lee
BACKGROUND: We developed a prognostic prediction model (PPM) using 4 factors for hepatic resection (HR) of large hepatic cellular carcinoma (HCC). Multiplication of α-fetoprotein (AFP), des-γ-carboxy prothrombin, and tumor volume (TV) (ADV score) is a surrogate marker for post-resection prognosis. This study intended to validate the predictive power of 4-factor PPM and to develop new ADV score-based PPM. METHODS: A total of 526 patients who underwent HR for solitary HCC ≥ 8 cm were selected from 9 Korean institutions between 2008 and 2014...
January 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29338105/multiple-sclerosis-long-term-outcomes-in-ethnic-minorities-with-ms-analysis-of-a-uk-population-based-registry
#3
Meshari O Alsaeed, Katharine E Harding, Owain H Williams, Mark D Willis, James Hrastelj, Emma C Tallantyre, Fady G Joseph, Mark Wardle, Trevor P Pickersgill, Neil P Robertson
BACKGROUND: Multiple sclerosis (MS) is most frequent in Caucasian populations. However, studies of MS in other ethnic groups may offer unique insights into genetic and environmental influences on disease, and data on long-term outcomes in these patients is limited. We have investigated clinical features and time to disability milestones in ethnic minority (EM) patients with MS in a UK population and made comparisons to a Caucasian cohort from the same region. METHODS: 1949 MS patients (1866 Caucasian, 83 EM) were identified from a regional disease registry...
January 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29331092/deep-grey-matter-volume-loss-drives-disability-worsening-in-multiple-sclerosis
#4
Arman Eshaghi, Ferran Prados, Wallace Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsing-remitting[RRMS], 128 secondary-progressive[SPMS], 125 primary-progressive[PPMS]), over an average follow-up of 2...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29318029/thrombin-generation-correlates-with-disease-duration-in-multiple-sclerosis-ms-novel-insights-into-the-ms-associated-prothrombotic-state
#5
Martin Em Parsons, Karen O'Connell, Seamus Allen, Karl Egan, Paulina B Szklanna, Christopher McGuigan, Fionnuala Ní Áinle, Patricia B Maguire
Background: Thrombin is well recognised for its role in the coagulation cascade but it also plays a role in inflammation, with enhanced thrombin generation observed in several inflammatory disorders. Although patients with multiple sclerosis (MS) have a higher incidence of thrombotic disease, thrombin generation has not been studied to date. Objectives: The aim of this study was to characterise calibrated automated thrombography parameters in patients with relapsing-remitting MS (RRMS) and primary progressive MS (PPMS) in comparison to healthy controls (HCs)...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29316044/global-transcriptome-profiling-of-mild-relapsing-remitting-versus-primary-progressive-multiple-sclerosis
#6
Marcus W Koch, Yaroslav Ilnytskyy, Andrey Golubov, Luanne M Metz, V Wee Yong, Olga Kovalchuk
BACKGROUND: Genetic research in MS mostly compares MS patients with healthy controls, but does not differentiate between MS disease courses. We compared peripheral blood gene expression patterns between extremes of MS phenotypes: patients with mild relapsing-remitting MS (mRRMS) and primary progressive MS (PPMS). METHODS: We analyzed global gene expression profiles of peripheral blood samples of age and gender matched patients with mRRMS and PPMS. Detailed bioinformatic and gene set enrichment analysis, pathway and principle component analyses were used to identify differentially expressed genes and pathways...
January 8, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29314625/long-term-pacemaker-dependency-and-impact-of-pacing-on-mortality-following-transcatheter-aortic-valve-replacement-with-the-lotus-valve
#7
Mohammad Alasti, Hashrul Rashid, Karthikeyan Rangasamy, Emily Kotschet, David Adam, Jeff Alison, Robert Gooley, Sarah Zaman
OBJECTIVES: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus™ valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. BACKGROUND: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. METHODS: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center...
January 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29260369/predictors-of-right-ventricular-pacing-and-pacemaker-dependence-in-transcatheter-aortic-valve-replacement-patients
#8
Esseim Sharma, Antony F Chu
PURPOSE: Transcatheter aortic valve replacement (TAVR) is an increasingly prevalent therapy in patients with severe symptomatic aortic stenosis. Conduction disturbances requiring permanent pacemaker (PPM) implantation are a known complication of TAVR. This study investigated the progression of cardiac conduction disease in the post-TAVR pacemaker population and identified predictors of post-TAVR right ventricular (RV) pacing dependence. METHODS: Prospectively collected echocardiographic, ECG, and PPM interrogation data of 262 consecutive patients who underwent TAVR with placement of a balloon-expandable valve at one institution from March 2012 to October 2016 were analyzed...
December 19, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29251423/in-situ-disinfection-through-photoinspired-radical-oxygen-species-storage-and-thermal-triggered-release-from-black-phosphorous-with-strengthened-chemical-stability
#9
Lei Tan, Jun Li, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Haobo Pan, Yufeng Zheng, Xianbao Wang, Shuilin Wu
Photodynamic therapy (PDT) utilizing light-induced reactive oxygen species (ROS) is a promising alternative to combat antibiotic-resistant bacteria and biofilm. However, the photosensitizer (PS)-modified surface only exhibits antibacterial properties in the presence of light. It is known that extended photoirradiation may lead to phototoxicity and tissue hypoxia, which greatly limits PDT efficiency, while ambient pathogens also have the opportunity to attach to biorelevant surfaces in medical facilities without light...
December 18, 2017: Small
https://www.readbyqxmd.com/read/29234305/functional-components-of-cognitive-impairment-in-multiple-sclerosis-a-cross-sectional-investigation
#10
Jordi A Matias-Guiu, Ana Cortés-Martínez, María Valles-Salgado, Celia Oreja-Guevara, Vanesa Pytel, Paloma Montero, Teresa Moreno-Ramos, Jorge Matias-Guiu
Background: Cognitive impairment is frequent and disabling in multiple sclerosis (MS). Changes in information processing speed constitute the most important cognitive deficit in MS. However, given the clinical and topographical variability of the disease, cognitive impairment may vary greatly and appear in other forms in addition to slower information processing speed. Our aim was to determine the frequency of cognitive impairment, the principal cognitive domains, and components involved in MS and to identify factors associated with presence of cognitive impairment in these patients in a large series of patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29232960/ocrelizumab-a-new-b-cell-therapy-for-relapsing-remitting-and-primary-progressive-multiple-sclerosis
#11
Amanda M Stahnke, Kathryn M Holt
OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of ocrelizumab, a new B-cell-targeted therapy for multiple sclerosis (MS). DATA SOURCES: A comprehensive search of PubMed and OVID/MEDLINE was conducted using search terms ocrelizumab and multiple sclerosis using the date range of 1946 through October 2017. STUDY SELECTION AND DATA EXTRACTION: All English-language, human-subject articles related to ocrelizumab and MS were evaluated...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29141813/the-neutrophil-to-lymphocyte-ratio-as-disease-actvity-marker-in-multiple-sclerosis-and-optic-neuritis
#12
A K Bisgaard, G Pihl-Jensen, J L Frederiksen
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The neutrophil-to-lymphocyte ratio (NLR) has been identified as a disease activity marker in several diseases. We aim to evaluate the significance of the NLR in the different subtypes of MS, optic neuritis (ON) and in relation to disease activity and Expanded Disability Status Scale (EDSS). METHODS: We included 378 patients and 813 healthy controls (HC) from The Nordic Reference Interval Project 2000 (NORIP)...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29121642/limbic-system-damage-in-ms-mri-assessment-and-correlations-with-clinical-testing
#13
Jie Wen, Dmitriy A Yablonskiy, Amber Salter, Anne H Cross
Volume loss in some limbic region structures has been observed in multiple sclerosis (MS) patients. However, in vivo evaluation of existing tissue cellular microstructure integrity has received less attention. The goal of studies reported here was to quantitatively assess loss of limbic system volumes and tissue integrity, and to evaluate associations of these measures with cognitive and physical dysfunction in MS patients. Thirty-one healthy controls (HC) and 80 MS patients, including 32 relapsing remitting (RRMS), 32 secondary progressive (SPMS) and 16 primary progressive (PPMS), participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29102453/timing-of-conduction-abnormalities-leading-to-permanent-pacemaker-insertion-after-transcatheter-aortic-valve-implantation-a-single-centre-review
#14
Daniel Ozier, Nevena Zivkovic, Gabby Elbaz-Greener, Sheldon M Singh, Harindra C Wijeysundera
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is the preferred alternative to traditional surgical aortic valve replacement; however, it remains expensive. One potential driver of cost is the need for postprocedural monitoring for conduction abnormalities after TAVI. Given the paucity of literature on the optimal length of monitoring, we aimed to determine when clinically significant conduction abnormalities leading to permanent pacemaker (PPM) insertion after TAVI were first identified...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29098964/misdiagnosis-of-graves-hyperthyroidism-due-to-therapeutic-biotin-intervention
#15
Yentl De Roeck, Eva Philipse, Theodorus B Twickler, Luc Van Gaal
BACKGROUND: Lately, high dose of biotin is often given orally to patients with a primary progressive multiple sclerosis (PPMS). However, the molecule biotin is also a principle compound in various analytic immunoassays. CLINICAL CASE: An asymptomatic 60-year-old woman with PPMS on high dose of biotin therapy (3 × 100 mg/d) displayed abnormal thyroid function tests (TSH 0.02 mU/l, fT4 > 103 pmol/l, and fT3 > 46 pmol/l). TSH was determined by a homogeneous sandwich chemiluminescent immunoassay and fT4 and fT3 were both determined by a homogeneous, sequential, chemiluminescent immunoassay...
November 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29055465/radiologically-isolated-syndrome-and-multiple-sclerosis
#16
REVIEW
B Yamout, M Al Khawajah
BACKGROUND: Incidental white matter lesions (WML) are increasingly seen on brain magnetic resonance imaging (MRI) in clinical practice. Demyelination consistent with MS is seen in 0.1-0.7% of the population as evident by autopsy and MRI studies. The term radiologically isolated syndrome (RIS) was coined to define a subgroup of patients with demyelinating lesions highly suggestive of multiple sclerosis (MS). The Okuda criteria for diagnosing RIS help in stratifying the risk of conversion to MS but RIS is still not considered a distinct MS phenotype...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29041866/-progressive-ms-macro-views-the-need-for-novel-clinical-trial-paradigms-to-enable-drug-development-for-progressive-ms
#17
P Zaratin, G Comi, D Leppert
This article outlines the principal challenges to establish a standard phase-2 approach for progressive multiple sclerosis (PMS) and presents referring strategies to accelerate the registration process via a guidance approved by regulatory agencies. Accordingly, the contribution of 'big datasets' for a better understanding of the natural history of primary-progressive multiple sclerosis (PPMS) and secondary-progressive multiple sclerosis (SPMS) and of their prognostic factors and the value of novel biomarkers are discussed...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29033561/specific-iga-against-pseudomonas-aeruginosa-in-severe-copd
#18
Laura Millares, Sara Martí, Carmen Ardanuy, Josefina Liñares, Salud Santos, Jordi Dorca, Marian García-Nuñez, Sara Quero, Eduard Monsó
BACKGROUND: The bronchial mucosa is protected by a specialized immune system focused on the prevention of colonization and infection by potentially pathogenic microorganisms (PPMs). Immunoglobulin A (IgA) is the principal antibody involved in this mechanism. A defective immune barrier may facilitate the recurrent presence of PPMs in COPD. PURPOSE: The aim of this study was to determine IgA-mediated bronchial specific immune responses against Pseudomonas aeruginosa in stable patients with severe disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29024167/imaging-spinal-cord-atrophy-in-progressive-myelopathies-htlv-i-associated-neurological-disease-ham-tsp-and-multiple-sclerosis-ms
#19
Shila Azodi, Govind Nair, Yoshimi Enose-Akahata, Emily Charlip, Ashley Vellucci, Irene Cortese, Jenifer Dwyer, B Jeanne Billioux, Chevaz Thomas, Joan Ohayon, Daniel S Reich, Steven Jacobson
OBJECTIVE: Previous work measures spinal cord thinning in chronic progressive myelopathies, including human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). Quantitative measurements of spinal cord atrophy are important in fully characterizing these and other spinal cord diseases. We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers. METHODS: Spinal cord cross-sectional area was measured in individuals (24 healthy controls [HCs], 17 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS], 17 secondary progressive MS [SPMS], and 40 primary progressive MS [PPMS]) from C1 to T10...
November 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28963581/pacemaker-implantation-after-tavi-predictors-of-av-block-persistence
#20
Luise Gaede, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Johannes Sperzel, Johannes Blumenstein, Alexander Berkowitsch, Thomas Walther, Christian Hamm, Albrecht Elsässer, Holger Nef, Helge Möllmann
AIMS: Approximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. METHODS AND RESULTS: Between 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM (n = 173) 14...
September 29, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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