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https://www.readbyqxmd.com/read/28220288/social-cognition-according-to-cognitive-impairment-in-different-clinical-phenotypes-of-multiple-sclerosis
#1
Cecile Dulau, Mathilde Deloire, Helene Diaz, Aurore Saubusse, Julie Charre-Morin, Antoinette Prouteau, Bruno Brochet
The objective of this study is to evaluate the relationship between social cognition (SC) and cognitive impairment in persons with multiple sclerosis (PwMS). A prospective study was conducted in 60 PwMS, 30 with relapsing-remitting MS (RRMS), 15 with secondary progressive MS (SPMS) and 15 with primary progressive MS (PPMS), and in healthy subjects (HS). All subjects were assessed by the Bordeaux Social Cognition Evaluation Protocol (PECS-B) (facial emotion recognition, theory of mind, emotional awareness and cognitive and affective alexithymia), by a large neuropsychological battery and by questionnaires (depression and anxiety)...
February 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28217422/exploration-of-score-agreement-on-a-modified-upper-quarter-y-balance-test-kit-as-compared-to-the-upper-quarter-y-balance-test
#2
Josh Cramer, Miguel Quintero, Alex Rhinehart, Caitlin Rutherford, Alan Nasypany, James May, Russell T Baker
BACKGROUND/PURPOSE: Physical performance measures (PPMs) such as The Star Excursion Balance Test (SEBT) and the Y-Balance Test (YBT) are functional movement tests used to assess participants' dynamic balance, which can be a vital component in physical exams to identify predisposing factors for risk of injury. The YBT is a functional assessment tool for the upper and lower body. It evolved from the SEBT, which has been previously used in research as a lower body functional assessment. It is comprised of fewer movement directions, which help limit fatigue...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28205364/altered-neural-mechanisms-of-cognitive-control-in-patients-with-primary-progressive-multiple-sclerosis-an-effective-connectivity-study
#3
Ekaterina Dobryakova, Maria Assunta Rocca, Paola Valsasina, John DeLuca, Massimo Filippi
Primary progressive multiple sclerosis (PPMS) leads to physical and cognitive disability. Specifically, cognitive deficits in PPMS have been explained by both grey matter atrophy and white matter lesions. However, existing research still lacks in the understanding of how the brain of a patient with PPMS functions under cognitive control demands. Thus, the aim of the current study was to examine information integration in patients with PPMS using a search-based effective connectivity method. Fourteen patients with PPMS and 22 age- and gender-matched healthy controls (HC) performed the Stroop task, a cognitively demanding interference task that taxes neural resources required for cognitive control and response inhibition...
February 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28166789/the-mrz-reaction-in-primary-progressive-multiple-sclerosis
#4
Tilman Hottenrott, Rick Dersch, Benjamin Berger, Sebastian Rauer, Daniela Huzly, Oliver Stich
BACKGROUND: The MRZ reaction (MRZR), composed of the three antibody indices (AI) against measles, rubella and varicella zoster virus and found positive in the majority of relapsing-remitting multiple sclerosis (RRMS) patients, is absent in other inflammatory neurological diseases (OIND). So far, it has been uncertain whether its differential diagnostic promise extends to patients with primary-progressive multiple sclerosis (PPMS). OBJECTIVE: To investigate the prevalence of MRZR in PPMS compared to RRMS and OIND patients...
February 7, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28129686/a-novel-approach-to-discriminate-subgroups-in-multiple-sclerosis
#5
Mehrdad Farrokhi, Zahra Saadatpour, Elyas Fadaee, Leila Saadatpour, Ali Rezaei, Pedram Moeini, Ali Amani Beni
Multiple sclerosis (MS) is an autoimmune disease of central nervous system. Since different types of immune cells are involved in MS pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble CD4 (sCD4), sCD8, sCD163, and immunoglobulins as markers of activity of T-cells, macrophages, and B-cells in different types of MS. Serum levels of sCD4, sCD8, and sCD163 of patients with relapsing-remitting MS (RRMS, n=61), primary progressive MS (PRMS, n=31), secondary progressive MS (SPMS, n=31), clinical isolated syndrome (CIS, n=31) and neuromyelitis optica (NMO, n=31), and healthy controls (n=49) were measured using enzyme-linked immunosorbent assay (ELISA)...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28107759/multiple-primary-pulmonary-meningiomas-20-year-follow-up-findings-for-a-first-reported-case-confirming-a-benign-biological-nature
#6
Yukitoshi Satoh, Yuichi Ishikawa
INTRODUCTION: Primary pulmonary meningiomas (PPMs) are very rare neoplasms, and we reported the first multiple case of PPMs in 1998. Usually, PPMs are slow-growing tumors with a good prognosis. Herein, we reported a rare multiple case of PPMs with an extremely long clinical course. PRESENTATION OF THE CASE: An 84-year-old Japanese woman with a history of multiple PPMs histologically confirmed as having a right-sided slowly growing lung nodule for 20 years. In 2010, we also reported the additional clinical course in the initial case 10 years after surgery implying a benign biological nature...
January 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28102398/low-temperature-heat-capacity-standard-entropy-standard-enthalpy-and-magnetic-property-a-new-1d-cu-ii-coordination-polymer-incorporating-tetrazole-1-acetic-acid-and-p-nitrobenzoic-acid
#7
Qi Yang, Jing Ge, Xin Liu, Quan Shi, Hongshan Ke, Qing Wei, Gang Xie, Sanping Chen, Shengli Gao
A new 1D Cu(II) coordination polymer, formulated as {[Cu(TZA)(PNA)]·H2O}n (1) (HTZA = tetrazole-1-acetic acid, HPNA = p-nitrobenzoic acid), was synthesized and structurally characterized. Thermogravimetric analysis demonstrated that the main frame of 1 exhibited good thermostability up to 473 K. The non-isothermal kinetics for the first exothermic process of 1 were studied by Kissinger and Ozawa methods. The magnetic study revealed that 1 possessed antiferromagnetic exchange interactions between Cu(II) ions through the carboxyl-bridge...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28088081/lead-pb-2-and-copper-cu-2-remediation-from-water-using-superparamagnetic-maghemite-%C3%AE-fe2o3-nanoparticles-synthesized-by-flame-spray-pyrolysis-fsp
#8
Shalini Rajput, Lok P Singh, Charles U Pittman, Dinesh Mohan
Superparamagnetic maghemite (γ-Fe2O3) nanoparticles of controllable morphology were successfully synthesized using a flame spray pyrolysis (FSP) technique. Their physico-chemical properties, size, morphology, and surface chemistries were determined using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), selected area electron diffraction patterns (SAED), SEM-EDX, scanning electron microscopy (SEM), and pHZPC(6.3). Elemental contents before and after adsorption were identified using energy dispersive X-ray fluorescence (ED-XRF), energy dispersive X-ray analysis (EDX) and elemental mapping...
April 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28081163/income-in-multiple-sclerosis-patients-with-different-disease-phenotypes
#9
Andrius Kavaliunas, Ali Manouchehrinia, Virginija Danylaite Karrenbauer, Hanna Gyllensten, Anna Glaser, Kristina Alexanderson, Jan Hillert
BACKGROUND: Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course. OBJECTIVE: To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive MS (SPMS). METHODS: A total of 6890 MS patients aged 21-64 years and living in Sweden in 2010 were identified for this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28035846/employment-and-absenteeism-in-working-age-persons-with-multiple-sclerosis
#10
Amber Salter, Nina Thomas, Tuula Tyry, Gary Cutter, Ruth Ann Marrie
AIMS: To better understand the impact of the clinical course of multiple sclerosis (MS) and disability on employment, absenteeism, and related factors. MATERIALS AND METHODS: We included respondents to the North American Research Committee on Multiple Sclerosis Registry spring 2015 update survey who were United States or Canadian residents, aged 18-65 years and reported having relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), or primary progressive MS (PPMS)...
December 30, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/28009943/corevalve-prosthesis-depth-what-is-the-optimal-measurement-target
#11
Rafael Wolff, Sam Radhakrishnan, Hirotsugu Mitsuhashi, Anna Zavodni, Idan Roifman, John D Sparkes, Stephen E Fremes, Sabina Bakar-Irwin, Mark S Hansen, Bradley H Strauss
BACKGROUND: A major drawback of the transcatheter aortic valve replacement (TAVR) procedure using the self-expandable Medtronic CoreValve (MCV) prosthesis is the high incidence of conduction disturbances and the need for postprocedural permanent pacemaker (PPM) implantation. The depth of prosthesis implantation may be an important contributing factor. The study aim was to determine the relationship between angiographic measurements of the MCV prosthesis depth and the occurrence of new conduction disturbances and need for PPM after TAVR...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27919195/efficacy-and-safety-of-mitoxantrone-use-in-primary-and-secondary-progressive-multiple-sclerosis-study-site-experience-based-on-the-therapy-of-104-patients
#12
Anetta Lasek-Bal, Karina Bartoszek, Arkadiusz Steposz, Przemyslaw Puz, Wieslaw Bal, Zofia Kazibutowska
: Mitoxantrone (MX) is used in patients with primary and secondary progressive as well as relapsing-remitting type of multiple sclerosis (PPMS, SPMS, RRMS). The objective of our project was to evaluate the efficacy and safety of MX use in patients with PPMS and SPMS. METHODS: The retrospective study included 104 patients (mean age 54.2 ± 9.0), with PPMS (13.46%) and SPMS (86.54%) treated with MX. During single cycle of the MX therapy a dose of 12 mg/m(2) of body surface area was administered and next cycles every three months up to a total dose of 140 mg/m(2) were realized...
December 23, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27882837/determining-multiple-sclerosis-phenotype-from-electronic-medical-records
#13
Richard E Nelson, Jorie Butler, Joanne LaFleur, Kristin Knippenberg, Aaron W C Kamauu, Scott L DuVall
BACKGROUND: Multiple sclerosis (MS), a central nervous system disease in which nerve signals are disrupted by scarring and demyelination, is classified into phenotypes depending on the patterns of cognitive or physical impairment progression: relapsing-remitting MS (RRMS), primary-progressive MS (PPMS), secondary-progressive MS (SPMS), or progressive-relapsing MS (PRMS). The phenotype is important in managing the disease and determining appropriate treatment. The ICD-9-CM code 340.0 is uninformative about MS phenotype, which increases the difficulty of studying the effects of phenotype on disease...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27865736/ips-derived-neural-progenitor-cells-from-ppms-patients-reveal-defect-in-myelin-injury-response
#14
Alexandra M Nicaise, Erin Banda, Rosa M Guzzo, Kristen Russomanno, Wanda Castro-Borrero, Cory M Willis, Kasey M Johnson, Albert C Lo, Stephen J Crocker
Primary progressive multiple sclerosis (PPMS) is a chronic demyelinating disease of the central nervous system (CNS) currently lacking any effective treatment. Promoting endogenous brain repair offers a potential strategy to halt and possibly restore neurologic function in PPMS. To understand how the microenvironment within white matter lesions plays a role in repair we have focused on neural progenitor cells (NPCs) since these are found in lesions in PPMS and have been found to influence oligodendrocyte progenitor cell maturation (OPCs)...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27795849/whole-genome-dna-methylation-analysis-of-peripheral-blood-mononuclear-cells-in-multiple-sclerosis-patients-with-different-disease-courses
#15
O G Kulakova, M R Kabilov, L V Danilova, E V Popova, O A Baturina, E Y Tsareva, N M Baulina, I S Kiselev, A N Boyko, A V Favorov, O O Favorova, V V Vlassov
Multiple sclerosis (MS) is a severe neurodegenerative disease of polygenic etiology affecting the central nervous system. In addition to genetic factors, epigenetic mechanisms, primarily DNA methylation, which regulate gene expression, play an important role in MS development and progression. In this study, we have performed the first whole-genome DNA methylation profiling of peripheral blood mononuclear cells in relapsing-remitting MS (RRMS) and primary-progressive MS (PPMS) patients and compared them to those of healthy individuals in order to identify the differentially methylated CpG-sites (DMSs) associated with these common clinical disease courses...
July 2016: Acta Naturae
https://www.readbyqxmd.com/read/27778334/cognitive-impairment-and-magnetic-resonance-imaging-correlates-in-primary-progressive-multiple-sclerosis
#16
A Gouveia, S P Dias, T Santos, H Rocha, C R Coelho, L Ruano, O Galego, M C Diogo, D Seixas, M J Sá, S Batista
OBJECTIVES: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. MATERIALS AND METHODS: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes...
October 24, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27763513/a-personalized-approach-in-progressive-multiple-sclerosis-the-current-status-of-disease-modifying-therapies-dmts-and-future-perspectives
#17
REVIEW
Emanuele D'Amico, Francesco Patti, Aurora Zanghì, Mario Zappia
Using the term of progressive multiple sclerosis (PMS), we considered a combined population of persons with secondary progressive MS (SPMS) and primary progressive MS (PPMS). These forms of MS cannot be challenged with efficacy by the licensed therapy. In the last years, several measures of risk estimation were developed for predicting clinical course in MS, but none is specific for the PMS forms. Personalized medicine is a therapeutic approach, based on identifying what might be the best therapy for an individual patient, taking into account the risk profile...
October 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27760868/rituximab-in-multiple-sclerosis-a-retrospective-observational-study-on-safety-and-efficacy
#18
Jonatan Salzer, Rasmus Svenningsson, Peter Alping, Lenka Novakova, Anna Björck, Katharina Fink, Protik Islam-Jakobsson, Clas Malmeström, Markus Axelsson, Mattias Vågberg, Peter Sundström, Jan Lycke, Fredrik Piehl, Anders Svenningsson
OBJECTIVE: To investigate the safety and efficacy of rituximab in multiple sclerosis (MS). METHODS: In this retrospective uncontrolled observational multicenter study, off-label rituximab-treated patients with MS were identified through the Swedish MS register. Outcome data were collected from the MS register and medical charts. Adverse events (AEs) grades 2-5 according to the Common Terminology Criteria for Adverse Events were recorded. RESULTS: A total of 822 rituximab-treated patients with MS were identified: 557 relapsing-remitting MS (RRMS), 198 secondary progressive MS (SPMS), and 67 primary progressive MS (PPMS)...
November 15, 2016: Neurology
https://www.readbyqxmd.com/read/27738090/age-and-disability-drive-cognitive-impairment-in-multiple-sclerosis-across-disease-subtypes
#19
Luis Ruano, Emilio Portaccio, Benedetta Goretti, Claudia Niccolai, Milton Severo, Francesco Patti, Sabina Cilia, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Maria Trojano, Rosa Gemma Viterbo, Maria Pia Amato
BACKGROUND: There is limited and inconsistent information on the clinical determinants of cognitive impairment (CI) in multiple sclerosis (MS). OBJECTIVE: The aim of this study was to compare the prevalence and profile of CI across MS disease subtypes and assess its clinical determinants. METHODS: Cognitive performance was assessed through the Brief Repeatable Battery and the Stroop test in consecutive patients with MS referred to six Italian centers...
October 13, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27725108/glial-and-neuronal-markers-in-cerebrospinal-fluid-in-different-types-of-multiple-sclerosis
#20
M Alba Mañé-Martínez, Bob Olsson, Laura Bau, Elisabet Matas, Álvaro Cobo-Calvo, Ulf Andreasson, Kaj Blennow, Lucia Romero-Pinel, Sergio Martínez-Yélamos, Henrik Zetterberg
In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients...
October 15, 2016: Journal of Neuroimmunology
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