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JOURNAL ARTICLE
Hijrah Nasir, Frederic Dutheil, Ines Ramos, Terry Guirado, Sarah de Saint-Vincent, David Thivel, Lore Metz, Martine Duclos
BACKGROUND: Sedentary behaviour at work is a major cause of atherosclerosis, particularly in tertiary workers. However, no studies have ever assessed the effect of active workstation on lipoprotein subfraction profile. This study aimed to evaluate the effect of 12-week portable pedal machines (PPMs) on lipoprotein subfraction profile among healthy sedentary workers. METHODS: Healthy administrative workers were randomized into an intervention group using PPMs for 12 weeks or a control group using normal-desk...
April 14, 2024: Lipids in Health and Disease
#2
JOURNAL ARTICLE
Yehuda Warszawer, Michael Gurevich, Ariel Kerpel, Sapir Dreyer Alster, Yael Nissan, Emanuel Shirbint, Chen Hoffmann, Anat Achiron
PURPOSE: Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and sub-cortical regions with those in healthy individuals. METHODS: We conducted retrospective analyses of brain volume using T1-weighted Magnetic Resonance Imaging (MRI) scans of a large cohort of PPMS patients and healthy subjects...
April 13, 2024: Neuroradiology
#3
JOURNAL ARTICLE
L Diem, A Ovchinnikov, C Friedli, H Hammer, N Kamber, A Chan, A Salmen, O Findling, R Hoepner
BACKGROUND: Ocrelizumab (OCR) is a humanized monoclonal antibody directed against CD-20 positive lymphocytes, mainly B-lymphocytes. OCR is approved for treatment of primary progressive (PPMS) and relapsing multiple sclerosis (RMS). This study aims to provide real-world safety and efficacy data of people with RMS treated with OCR in two Swiss Multiple Sclerosis (MS) centers. METHODS: We have conducted a retrospective data analysis using the patient cohorts from the Cantonal Hospital Aarau and Bern University Hospital (RMS: n = 235)...
March 30, 2024: Multiple Sclerosis and related Disorders
#4
JOURNAL ARTICLE
Maged Abdel Naseer, Hatem Samir Shehata, Sarah Khalil, Amr Mohamed Fouad, Hend Abdelghany
BACKGROUND: Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system. It is characterized by symptoms such as visual disturbances, paresis with spasticity, paresthesia, numbness, and fatigue. However, several studies have shown a high prevalence of headaches in individuals with MS. Migraine and tension-type headaches are the most frequent types of headaches experienced by those with MS. Additionally, the role of MS disease-modifying agents must be considered...
April 3, 2024: Multiple Sclerosis and related Disorders
#5
JOURNAL ARTICLE
Juan Luis Chico-Garcia, Raquel Sainz-Amo, Enric Monreal, Fernando Rodriguez-Jorge, Susana Sainz de la Maza, Jaime Masjuan, Luisa María Villar, Lucienne Costa-Frossard França
INTRODUCTION: Continuously acquired smartphone keyboard interactions may be useful to monitor progression in multiple sclerosis (MS). We aimed to study the correlation between tapping speed (TS), measured as keys/s, and baseline disability scales in patients with MS. METHODS: Single-center prospective study in patients with MS. We passively assessed TS during first week, measured by an "in house" smartphone application. Reliability was assessed by intraclass correlation coefficient (ICC)...
March 30, 2024: Multiple Sclerosis and related Disorders
#6
Karin M Cox, Daisuke Kase, Taieb Znati, Robert S Turner
OBJECTIVE: Oscillations figure prominently as neurological disease hallmarks and neuromodulation targets. To detect oscillations in a neuron's spiking, one might attempt to seek peaks in the spike train's power spectral density (PSD) which exceed a flat baseline. Yet for a non-oscillating neuron, the PSD is not flat: The recovery period ("RP", the post-spike drop in spike probability, starting with the refractory period) introduces global spectral distortion. An established "shuffling" procedure corrects for RP distortion by removing the spectral component explained by the inter-spike interval (ISI) distribution...
March 25, 2024: bioRxiv
#7
JOURNAL ARTICLE
Cathérine Dekeyser, Matthias Hautekeete, Melissa Cambron, Vincent Van Pesch, Francesco Patti, Jens Kuhle, Samia Khoury, Jeanette Lechner Scott, Oliver Gerlach, Alessandra Lugaresi, Davide Maimone, Andrea Surcinelli, Pierre Grammond, Tomas Kalincik, Mario Habek, Barbara Willekens, Richard Macdonell, Patrice Lalive, Tunde Csepany, Helmut Butzkueven, Cavit Boz, Valentina Tomassini, Matteo Foschi, José Luis Sánchez-Menoyo, Ayse Altintas, Saloua Mrabet, Gerardo Iuliano, Maria Jose Sa, Raed Alroughani, Rana Karabudak, Eduardo Aguera-Morales, Orla Gray, Koen de Gans, Anneke van der Walt, Pamela A McCombe, Norma Deri, Justin Garber, Abdullah Al-Asmi, Olga Skibina, Pierre Duquette, Elisabetta Cartechini, Daniele Spitaleri, Riadh Gouider, Aysun Soysal, Liesbeth Van Hijfte, Mark Slee, Maria Pia Amato, Katherine Buzzard, Guy Laureys
BACKGROUND: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. METHODS: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#8
Rabia Deniz, Gülşah Hacımurtazaoğlu-Demir, Bilgin Karaalioğlu, Duygu Sevinç Özgür, Gamze Akkuzu, Fatih Yıldırım, Cemal Bes
The triad of ascites, pleural effusion, and elevated cancer antigen-125 (CA-125) levels in the absence of ovarian malignancy in systemic lupus erythematosus patients is specifically named pseudo-pseudo Meigs' syndrome (PPMS) or Tjalma syndrome. In this case we reported a 33 years female patient with pleural effusion lasting for 3 years and new onset progressive massive ascites and increased level of CA-125. After she was evaluated for an underlying benign and malign ovarian tumor or any other malignancies, serologic tests were requested with respect to progressive renal dysfunction, proteinuria, lymphopenia, anemia, and effusion...
April 1, 2024: Journal of rheumatic diseases
#9
Somei Matsuo, Naoki Kanauchi
Primary pulmonary meningiomas (PPMs) are rare meningothelial proliferation that lacks characteristic imaging findings, making their distinction from other peripheral lung tumors challenging. Therefore, surgical resection is often performed for the diagnosis and treatment of PPM. Herein, we describe a surgical case of PPM that grew over 10 years. A 63-year-old woman was referred to our department due to right middle lobe lung tumor enlargement. No significant symptoms were observed. Chest computed tomography revealed a tumor in the middle lobe of the right lung...
February 2024: Curēus
#10
REVIEW
Shitiz Sriwastava, Mahmoud Elkhooly, Suban Amatya, Kriti Shrestha, Yusuf Kagzi, Dipika Bhatia, Rajesh Gupta, Shruti Jaiswal, Robert P Lisak
BACKGROUND: The article highlights upcoming potential treatments, which target different phases of inflammation and offer remyelinating strategies as well as direct and indirect neuroprotective and oligodendrocyte protective effects, providing a hopeful outlook for patients with primary and secondary progressive multiple sclerosis (PPMS and SPMS). OBJECTIVES: The review aims to identify potential treatments and ongoing clinical trials for PPMS and SPMS, and compare their mechanisms of action, efficacy, and side effects with current treatments...
February 17, 2024: Journal of Neuroimmunology
#11
JOURNAL ARTICLE
Daniel Gajda, Michał Babij, Andrzej Zaleski, Doğan Avci, Fırat Karaboga, Hakan Yetis, Ibrahim Belenli, Tomasz Czujko
Currently, MgB2 wires made by the powder-in-tube (PIT) method are most often used in the construction and design of superconducting devices. In this work, we investigated the impact of heat treatment under both low and high isostatic pressures on the formation of a layered structure in PIT MgB2 wires manufactured using the Mg coating method. The microstructure, chemical composition, and density of the obtained superconductive wires were investigated using scanning electron microscopy (SEM) with an energy-dispersive X-ray spectroscopy (EDS) analyzer and optical microscopy with Kameram CMOS software (version 2...
March 16, 2024: Materials
#12
JOURNAL ARTICLE
Vineet Kumar, Fuad Ameen, Pradeep Verma
Pulp-paper mills (PPMs) are known for consistently generating a wide variety of pollutants, that are often unidentified and highly resistant to environmental degradation. The current study aims to investigate the changes in the indigenous bacterial communities profile grown in the sediment co-contaminated with organic and inorganic pollutants discharged from the PPMs. The two sediment samples, designated PPS-1 and PPS-2, were collected from two different sites. Physico-chemical characterization of PPS-1 and PPS-2 revealed the presence of heavy metals (mg kg-1 ) like Cu (0...
2024: Frontiers in Microbiology
#13
JOURNAL ARTICLE
M Aminul Islam, Ishtiaque M Syed, M Al Mamun, S Manjura Hoque
In this study, Mg1 -x Co x Fe2 O4 (0 ≤ x ≤ 1 with ∆x = 0.1) or MCFO nanoparticles were synthesized using a chemical co-precipitation method and annealed at 200, 400, 600, and 800°C respectively to investigate the structural properties of the materials by X-ray diffractometer (XRD), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). Controlled annealing increased particle size for each value of x. The aim was to investigate how specific loss power (SLP) and maximum temperature (T max ) during local magnetic hyperthermia were affected by structural alterations associated with particle size and composition...
2024: Frontiers in Chemistry
#14
JOURNAL ARTICLE
Tao Xu, Yueqian Zheng, Xuan Wang, Zhi Sun, Bai Han
Studying the dielectric response of topological insulators (TIs) can unveil their unique physical mechanisms such as charge transport and spin-orbit coupling effects. However, due to the manifestation of material's topological nature and band structure primarily in nanofilm, such thickness poses challenges for dielectric testing. To date, research on TI dielectric aspects remains relatively unexplored. Therefore, this paper successfully synthesizes nanofilm of quaternary topological insulator Bi1 · 2 Sb0 · 8 Te0 · 4 Se2...
March 30, 2024: Heliyon
#15
JOURNAL ARTICLE
Matthew Dai, Connor Peterson, Udi Chorin, Orly Leiva, Moshe Katz, Hend Sliman, Anthony Aizer, Chirag Barbhaiya, Scott Bernstein, Douglas Holmes, Robert Knotts, David Park, Michael Spinelli, Larry Chinitz, Lior Jankelson
BACKGROUND: Many patients with mild to moderately reduced left ventricular ejection fraction (LVEF) that require permanent pacemaker (PPM) implantation do not have a concurrent indication for implantable cardioverter-defibrillator (ICD) therapy. However, the risk of ventricular tachycardia/fibrillation (VT/VF) in this population is unknown. OBJECTIVE: To describe the risk of VT/VF following PPM implantation in patients with mild to moderately reduced LVEF. METHODS: Retrospective analysis was performed on 243 patients with LVEF between 35-49% who underwent PPM placement, and did not meet indications for an ICD...
March 13, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#16
JOURNAL ARTICLE
Comprehensive kinetic modeling and product distribution for pyrolysis of pulp and paper mill sludge.
Fangjun Chen, Lei Ding, Yongfeng Zhu, Guanlong Ren, Yi Man, Kun Hong, Lin Lang, Henrik Ström, Qingang Xiong
Pyrolysis holds immense potential for clean treatment of pulp and paper mill sludge (PPMS), enabling efficient energy and chemical recovery. However, current understanding of PPMS pyrolysis kinetics and product characteristics remains incomplete. This study conducted detailed modeling of pyrolysis kinetics for two typical PPMSs from a wastepaper pulp and paper mill, namely, deinking sludge (PPMS-DS) and sewage sludge (PPMS-SS), and analyzed comprehensively pyrolysis products. The results show that apparent activation energy of PPMS-DS (169...
March 13, 2024: Science of the Total Environment
#17
JOURNAL ARTICLE
Mikel Gurrea-Rubio, Qin Wang, Elizabeth A Mills, Qi Wu, David Pitt, Pei-Suen Tsou, David A Fox, Yang Mao-Draayer
Multiple sclerosis (MS) is the most common autoimmune demyelinating disease of the central nervous system (CNS), consisting of heterogeneous clinical courses varying from relapsing-remitting MS (RRMS), in which disability is linked to bouts of inflammation, to progressive disease such as primary progressive MS (PPMS) and secondary progressive MS (SPMS), in which neurological disability is thought to be linked to neurodegeneration. As a result, successful therapeutics for progressive MS likely need to have both anti-inflammatory and direct neuroprotective properties...
February 20, 2024: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Anne H Cross, Jeffrey M Gelfand, Simon Thebault, Jeffrey L Bennett, H Christian von Büdingen, Briana Cameron, Robert Carruthers, Keith Edwards, Robert Fallis, Rachel Gerstein, Paul S Giacomini, Benjamin Greenberg, David A Hafler, Carolina Ionete, Ulrike W Kaunzner, Lay Kodama, Christopher Lock, Erin E Longbrake, Bruno Musch, Gabriel Pardo, Fredrik Piehl, Martin S Weber, Steven Yuen, Tjalf Ziemssen, Gauruv Bose, Mark S Freedman, Veronica G Anania, Akshaya Ramesh, Ryan C Winger, Xiaoming Jia, Ann Herman, Christopher Harp, Amit Bar-Or
IMPORTANCE: Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing biology in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible fluid that most closely reflects central nervous system biology. OBJECTIVE: To identify CSF biological measures associated with progressive MS pathobiology. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed data from 2 prospective MS cohorts: a test cohort provided serial CSF, clinical, and imaging assessments in a multicenter study of patients with relapsing MS (RMS) or primary progressive MS (PPMS) who were initiating anti-CD20 treatment (recruitment: 2016-2018; analysis: 2020-2023)...
March 11, 2024: JAMA Neurology
#19
JOURNAL ARTICLE
Min Qiu, Yaru Sun, Siqun Tu, Huaibo Li, Xin Yang, Haiyang Zhao, Maozhu Yin, Yaning Li, Wenwu Ye, Ming Wang, Yuanchao Wang
Phosphatases are important regulators of protein phosphorylation and various cellular processes, and they serve as counterparts to kinases. In this study, our comprehensive analysis of oomycete complete proteomes unveiled the presence of approximately 3833 phosphatases, with most species estimated to have between 100 and 300 putative phosphatases. Further investigation of these phosphatases revealed a significant increase in protein serine/threonine phosphatases (PSP) within oomycetes. In particular, we extensively studied the metallo-dependent protein phosphatase (PPM) within the PSP family in the model oomycete Phytophthora sojae...
March 2024: Molecular Plant Pathology
#20
JOURNAL ARTICLE
Aleksandar Stojsavljević, Jovana Jagodić, Slađan Pavlović, Evica Dinčić, Jovana Kuveljić, Dragan Manojlović, Maja Živković
BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating disorder intricately linked to perturbations in trace element levels. While previous studies have explored circulating trace elements in a limited sample, understanding the impact of demographic and clinical variables on the elemental profile within a larger cohort remains elusive. METHODS: This study aimed to evaluate essential trace elements (Cr, Mn, Co, Cu, Zn, and Se) in the sera of 215 MS patients compared to a meticulously matched control group of 100 individuals with similar gender and age...
March 2, 2024: Journal of Trace Elements in Medicine and Biology
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