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https://www.readbyqxmd.com/read/29781383/preferential-spinal-cord-volume-loss-in-primary-progressive-multiple-sclerosis
#1
Charidimos Tsagkas, Stefano Magon, Laura Gaetano, Simon Pezold, Yvonne Naegelin, Michael Amann, Christoph Stippich, Philippe Cattin, Jens Wuerfel, Oliver Bieri, Till Sprenger, Ludwig Kappos, Katrin Parmar
BACKGROUND: Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS). OBJECTIVE: Longitudinal evaluation of SCV loss in PPMS and its correlation to clinical outcomes, compared to relapse-onset multiple sclerosis (MS) subtypes. METHODS: A total of 60 MS age-, sex- and disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) and secondary progressive MS (SPMS)) were analysed annually over 6 years of follow-up...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29780609/serum-heat-shock-protein-70-levels-as-a-biomarker-for-inflammatory-processes-in-multiple-sclerosis
#2
Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Background: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. Objective: The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Methods: Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing-remitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS)...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29780394/monosodium-urate-crystals-activate-the-inflammasome-in-primary-progressive-multiple-sclerosis
#3
Federica Piancone, Marina Saresella, Ivana Marventano, Francesca La Rosa, Maria Antonia Santangelo, Domenico Caputo, Laura Mendozzi, Marco Rovaris, Mario Clerici
Inflammasome-driven inflammation is postulated to play a role in multiple sclerosis (MS), but there is no direct evidence that the nod-like receptor protein 3 (NLRP3) inflammasome is involved in MS pathogenesis. Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals. To better investigate the role of the NLRP3 inflammasome in MS-associated inflammation, we primed with lipopolysaccharide and stimulated with monosodium urate crystals PBMCs of 41 MS patients with different disease phenotypes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29774057/ocrelizumab-a-new-milestone-in-multiple-sclerosis-therapy
#4
REVIEW
Patricia Mulero, Luciana Midaglia, Xavier Montalban
B cells play a central role in the pathogenesis of multiple sclerosis (MS): they are involved in the activation of pro-inflammatory T cells, secretion of pro-inflammatory cytokines and production of autoantibodies directed against myelin. Hence, the use of B cell-depleting monoclonal antibodies as therapy for autoimmune diseases, including MS, has increased in recent years. Previous results with rituximab, the first therapeutic B cell-depleting chimeric monoclonal antibody that showed efficacy in MS clinical trials, encouraged researchers to evaluate the efficacy of a humanized anti-CD20 antibody, ocrelizumab, in MS...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29743290/cerebrospinal-fluid-immunoglobulin-light-chain-ratios-predict-disease-progression-in-multiple-sclerosis
#5
Emma Rathbone, Lindsay Durant, James Kinsella, Antony R Parker, Ghaniah Hassan-Smith, Michael R Douglas, S John Curnow
OBJECTIVE: To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts. METHODS: CSF and peripheral blood were obtained from patients undergoing elective diagnostic lumbar puncture and included clinically isolated syndrome (CIS) (n=43), relapsing remitting MS (RRMS; n=50), primary progressive MS (PPMS; n=20) and other neurological disease controls, both inflammatory (ONID; n=23) and non-inflammatory (OND; n=114)...
May 9, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29731474/a-case-of-unusual-persistent-pupillary-membrane-with-total-anterior-capsular-pigmentation
#6
SeongJin Yun, Seonmi Kang, Kangmoon Seo
A 5-year-old castrated male poodle presented with blindness. Ophthalmic examinations including slit-lamp biomicroscopy, tonometry, ultrasonography, and electroretinography, were performed. The anterior lens capsule of the right eye (OD) was totally pigmented, with persistent pupillary membranes (PPMs). Ultrasonography of the same eye showed severe lens atrophy and retinal detachment. Electroretinography revealed flat a- and b-waves in OD, but normal amplitudes in the left eye (OS). No ocular defects were detected in OS except mature cataract...
May 4, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29718593/primary-pulmonary-meningioma-presenting-as-a-micro-solid-nodule-a-rare-case-report
#7
Kai-Kai Xu, Feng Tian, Yong Cui
An ectopic meningioma, such as a primary pulmonary meningioma (PPM), is a rare type of tumor that primarily originates outside of the central nervous system. A 65-year-old female patient underwent a thoracoscopic lung wedge resection of the right lower lobe for a micro solid nodule detected via computed tomography. The histologic result revealed a PPM. PPMs manifested with micro solid nodules are a very rare occurrence in clinical practice. Increased awareness of the clinical and pathological characteristics of this rare disease can assist thoracic surgical teams to apply adequate management...
May 2, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29688322/conduction-dynamics-after-transcatheter-aortic-valve-implantation-and-implications-for-permanent-pacemaker-implantation-and-early-discharge-the-conduct-study
#8
Lennart van Gils, Sara Baart, Herbert Kroon, Zouhair Rahhab, Nahid El Faquir, Ramón Rodriguez Olivares, Yaar Aga, Anne-Marie Maugenest, Dominic A Theuns, Eric Boersma, Tamas Szili Torok, Peter P De Jaegere, Nicolas M Van Mieghem
Aims: To correlate dynamics in electrical conduction after transcatheter aortic valve implantation (TAVI) with need for permanent pacemaker implantation (PPM) and assess implications for early discharge. Methods and results: Daily electrocardiograms after TAVI were analysed for rhythm and conduction times and were correlated with PPM. Transcatheter aortic valve implantation was performed in 291 consecutive patients with three contemporary transcatheter heart valve designs: Medtronic CoreValve (n = 111), Edwards Sapien XT (n = 29) and Sapien 3 (n = 72), and Boston Lotus (n = 79)...
April 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29675858/effect-of-heat-treatment-on-the-microstructure-and-properties-of-ni-based-soft-magnetic-alloy
#9
Chunhong Li, Hui Ruan, Dengming Chen, Kejian Li, Donglin Guo, Bin Shao
A Ni-based alloy was heat treated by changing the temperature and ambient atmosphere of the heat treatment. Morphology, crystal structure, and physical performance of the Ni-based alloy were characterized via SEM, XRD, TEM, and PPMS. Results show that due to the heat treatment process, the grain growth of the Ni-based alloy and the removal of impurities and defects are promoted. Both the orientation and stress caused by rolling are reduced. The permeability and saturation magnetization of the alloy are improved...
April 20, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29664341/cervical-cord-t1-weighted-hypointense-lesions-at-mr-imaging-in-multiple-sclerosis-relationship-to-cord-atrophy-and-disability
#10
Paola Valsasina, Mohammed Aboulwafa, Paolo Preziosa, Roberta Messina, Andrea Falini, Giancarlo Comi, Massimo Filippi, Maria A Rocca
Purpose To characterize the spatial distribution of cervical cord T1-weighted hypointense lesions in patients with multiple sclerosis (MS) and analyze their association with cord atrophy and disability. Materials and Methods For this prospective study that took place between 2014 and 2016, 3.0-T high-resolution T1-weighted cervical cord magnetic resonance (MR) images and clinical evaluations were obtained from 82 patients with relapsing-remitting MS (RRMS), 33 patients with secondary progressive MS (SPMS), 25 patients with primary progressive MS (PPMS), and 35 sex-matched healthy control participants...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29656271/spanish-validation-of-a-specific-measure-to-assess-work-related-problems-in-people-with-multiple-sclerosis-the-multiple-sclerosis-work-difficulties-questionnaire-mswdq-23
#11
María L Martínez-Ginés, Jose M García-Domínguez, Lucía Forero, Neus Canal, Pablo Rebollo, Daniel Prefasi, Cynthia A Honan, Jorge Maurino
INTRODUCTION: Unemployment is a significant problem for people with multiple sclerosis (MS). The MS Work Difficulties Questionnaire (MSWDQ-23) is a self-report tool to assess work-related problems in people with MS across three domains: physical, psychological/cognitive, and external barriers. The aim of this study was to assess the psychometric properties of the Spanish version of the MSWDQ-23. METHODS: A multicentre, non-interventional, cross-sectional study in adult patients with relapsing-remitting multiple sclerosis (RRMS) or primary progressive (PPMS) multiple sclerosis (McDonald 2010 criteria) was conducted...
April 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29627873/disease-modifying-treatment-in-progressive-multiple-sclerosis
#12
REVIEW
John Robert Ciotti, Anne Haney Cross
PURPOSE OF REVIEW: Multiple sclerosis (MS) is an immune-mediated disorder that affects the central nervous system (CNS), often first affecting people in early adulthood. Although most MS patients have a relapsing-remitting course (RRMS) at disease onset, a substantial proportion later develop chronic progression, termed secondary progressive MS (SPMS). Approximately 10% of MS patients experience chronic progression from disease onset, termed primary progressive multiple sclerosis (PPMS)...
April 7, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29625878/evaluation-of-biodegradation-feasibility-through-rotary-drum-composting-recalcitrant-primary-paper-mill-sludge
#13
Jayeeta Hazarika, Meena Khwairakpam
Primary paper mill sludge (PPMS) is the major waste expelled from the pulp and paper industries contributing soil and water pollution through the recalcitrant organic and inorganic constituents. These pollutants can, however, be transformed into a high-value soil ameliorating material with nominal investment and time. Current study therefore evaluated the potential of rotary drum composting PPMS for 20 days to delineate an environmentally sustainable option. Five trials with proportions of PPMS, cow dung and saw dust: Trial 1 (10:0:0), Trial 2 (8:1:1), Trial 3 (7:2:1), Trial 4 (6:3:1) and Trial 5 (5:4:1) were performed for evaluation of degrading and nutritive ability along with the fate of pollutants for total mass of 150 kg...
April 3, 2018: Waste Management
https://www.readbyqxmd.com/read/29616217/thermal-expansion-and-magnetostriction-measurements-at-cryogenic-temperature-using-the-strain-gauge-method
#14
Wei Wang, Huiming Liu, Rongjin Huang, Yuqiang Zhao, Chuangjun Huang, Shibin Guo, Yi Shan, Laifeng Li
Thermal expansion and magnetostriction, the strain responses of a material to temperature and a magnetic field, especially properties at low temperature, are extremely useful to study electronic and phononic properties, phase transitions, quantum criticality, and other interesting phenomena in cryogenic engineering and materials science. However, traditional dilatometers cannot provide magnetic field and ultra-low temperature (<77 K) environment easily. This paper describes the design and test results of thermal expansion and magnetostriction at cryogenic temperature using the strain gauge method based on a Physical Properties Measurements System (PPMS)...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29598854/utility-of-invasive-electrophysiology-studies-in-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-implantation
#15
Toby Rogers, Mithun Devraj, Athanasios Thomaides, Arie Steinvil, Michael J Lipinski, Kyle D Buchanan, M Chadi Alraies, Edward Koifman, Jiaxiang Gai, Rebecca Torguson, Petros Okubagzi, Itsik Ben-Dor, Augusto D Pichard, Lowell F Satler, Ron Waksman
Permanent pacemaker (PPM) implantation remains common after transcatheter aortic valve implantation (TAVI). Invasive electrophysiology studies (EPSs) may reduce PPM implantation rates by identifying patients who do not require long-term pacing. At our institution, a new strategy in which patients with equivocal indications for pacing underwent EPSs to determine the need for PPM implantation was adopted. We compared baseline demographics, TAVI procedural details, and outcomes in patients without any conduction disturbance after TAVI, patients with new PPM implantation, and patients with EPS ± new PPM implantation...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29583131/experimental-investigations-and-micromagnetic-simulations-of-hybrid-cocr2o4-ni-coaxial-nanostructures
#16
Wenjing Li, Chengjie Wang, Xiaomin Zhang, Muhammad Irfan, Usman Khan, Yaowen Liu, Xiufeng Han
Multiphase CoCr2O4/Ni core-shell nanowires (NWs) have been synthesized within the anodic aluminum oxide (AAO) membranes by the combination of sol-gel methods with electrodeposition techniques. X-ray diffraction (XRD) and X-ray photoemission spectroscopy (XPS) results confirmed the formation of cubic spinel structure of CoCr2O4 shell with space group Fd-3m (227). The morphology and composition of the as-grown NWs were studied by field emission scanning electron microscope (FE-SEM), as well as transmission electron microscope (TEM)...
March 27, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29554927/mog-igg-in-primary-and-secondary-chronic-progressive-multiple-sclerosis-a-multicenter-study-of-200-patients-and-review-of-the-literature
#17
S Jarius, K Ruprecht, J P Stellmann, A Huss, I Ayzenberg, A Willing, C Trebst, M Pawlitzki, A Abdelhak, T Grüter, F Leypoldt, J Haas, I Kleiter, H Tumani, K Fechner, M Reindl, F Paul, B Wildemann
BACKGROUND: Antibodies to human full-length myelin oligodendrocyte glycoprotein (MOG-IgG) as detected by new-generation cell-based assays have recently been described in patients presenting with acute demyelinating disease of the central nervous system, including patients previously diagnosed with multiple sclerosis (MS). However, only limited data are available on the relevance of MOG-IgG testing in patients with chronic progressive demyelinating disease. It is unclear if patients with primary progressive MS (PPMS) or secondary progressive MS (SPMS) should routinely be tested for MOG-IgG...
March 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29527713/evaluation-of-serum-mir-191-5p-mir-24-3p-mir-128-3p-and-mir-376c-3-in-multiple-sclerosis-patients
#18
J Vistbakka, M-L Sumelahti, T Lehtimäki, I Elovaara, S Hagman
BACKGROUND: Biomarkers that could be used in early diagnosis of multiple sclerosis (MS), segregation of disease subtypes, and discrimination of the aggressive disease course from the benign one are urgently needed. OBJECTIVE: The aim of this study was to investigate the specificity of circulating microRNAs: miR-191-5p, miR-128-3p, miR-24-3p, and miR-376c-3p in MS and evaluate their association with disease activity and disability progression. METHODS: The expressions of circulating miRNAs were studied in serum of 100 subjects (53 relapsing-remitting (RRMS), 20 primary progressive (PPMS), and 27 controls), using miScript serum miRNA RT-PCR assay techniques...
March 12, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29503547/pediatric-onset-multiple-sclerosis-in-egypt-a-multi-center-registry-of-186-patients
#19
Sherif M Hamdy, Maged Abdel-Naseer, Nevin M Shalaby, Alaa Elmazny, Marian Girgis, Mona A Nada, Amr Hassan, Husam S Mourad, Mohamed I Hegazy, Ahmed Abdelalim, Nirmeen A Kishk, Noha T Abokrysha, Shaimaa A Genedy, Ehab A Essawy, Hatem S Shehata
Introduction: Although the frequency of pediatric-onset multiple sclerosis (POMS) has increased in recent decades, it is still highly uncommon, which creates a need for the involvement of more registries from various clinical centers. Objective: To characterize the demographic, clinical, and paraclinical features of Egyptian patients with POMS. Patients and methods: A retrospective chart review study was undertaken on 237 Egyptian patients with demyelinating events which started before the age of 18 years who attended one of five tertiary referral centers in Cairo, Egypt...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29501849/a-systematic-review-about-the-epidemiology-of-primary-progressive-multiple-sclerosis-in-latin-america-and-the-caribbean
#20
Juan Ignacio Rojas, Marina Romano, Liliana Patrucco, Edgardo Cristiano
Novel epidemiological data has appeared in recent years in Latin America (LATAM) regarding the epidemiology of multiple sclerosis (MS); however, most of this information is related to all MS subtypes, and no specific data was collected regarding the primary progressive form of MS (PPMS). The objective of this study was to perform an updated systematic review of the epidemiology of PPMS in LATAM. METHODS: We conducted a systematic review of published epidemiological articles of PPMS from January 1997 to June 2017...
February 24, 2018: Multiple Sclerosis and related Disorders
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