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JOURNAL ARTICLE
Alessia Bianchi, Rosa Cortese, Ferran Prados, Carmen Tur, Baris Kanber, Marios C Yiannakas, Rebecca Samson, Floriana De Angelis, Lise Magnollay, Anu Jacob, Wallace Brownlee, Anand Trip, Richard Nicholas, Yael Hacohen, Frederik Barkhof, Olga Ciccarelli, Ahmed T Toosy
BACKGROUND: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated. AIMS: To examine OC differences in non-acute IDD patients with (ON+) and without ON (ON-) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers...
April 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
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JOURNAL ARTICLE
Julia Sabin, Elisa Salas, Jesús Martín-Martínez, Antonio Candeliere-Merlicco, Francisco Javier Barrero, Ana Alonso, José Luis Sánchez-Menoyo, Laura Borrega, María Rodríguez-Rodríguez, Montserrat Gómez-Gutiérrez, Sara Eichau, Miguel Ángel Hernández-Pérez, Carmen Calles, Eva Fernández-Díaz, Olga Carmona, Aida Orvíz, Ana López-Real, Pablo López-Muñoz, Amelia Mendoza, Eduardo Agüera, Jorge Maurino, Javier Ballesteros
A multicenter study involving 204 adults with relapsing-remitting multiple sclerosis (RRMS) assessed the dimensionality and item characteristics of the Mishel-Uncertainty of Illness Scale (MUIS), a generic self-assessment tool. Mokken analysis identified two dimensions in the MUIS with an appropriate item and overall scale scalability after excluding nonclassifiable items. A refined 12-item MUIS, employing a grade response model, effectively discriminated uncertainty levels among RRMS patients (likelihood ratio test p -value = ...
2024: Multiple Sclerosis Journal—Experimental, Translational and Clinical
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JOURNAL ARTICLE
Meriam Belghith, Olfa Maghrebi, Rafika Ben Laamari, Mariem Hanachi, Sana Hrir, Zakaria Saied, Samir Belal, Adel Driss, Samia Ben Sassi, Thouraya Boussoffara, Mohamed-Ridha Barbouche
Remitting-Relapsing Multiple Sclerosis (RRMS) and Neuro-Behçet Disease (NBD) are two chronic neuro-inflammatory disorders leading to brain damage and disability in young adults. Herein, we investigated in these patients the cytokine response by beads-based multiplex assays during the early stages of these disorders. Cytokine investigations were carried out on treatment-naive patients suffering from RRMS and NBD recruited at the first episode of clinical relapse. Our findings demonstrate that Cerebrospinal Fluid (CSF) cells from NBD patients, but not RRMS, secrete significant high levels of IL-22 which is associated with elevated IL-22 mRNA expression...
April 16, 2024: Cytokine
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JOURNAL ARTICLE
Jonathan Metts, Wei Xue, Zhengya Gao, Sapna Oberoi, Aaron R Weiss, Rajkumar Venkatramani, Douglas J Harrison
BACKGROUND: Novel therapies are needed for relapsed and refractory rhabdomyosarcoma (RRMS). Phase II clinical trials in RRMS have typically utilized radiologic response as the primary activity endpoint, an approach that poses several limitations in RRMS. In this analysis, we aimed to estimate an event-free survival (EFS) endpoint for RRMS that could be used as a benchmark for future studies. PROCEDURE: We performed a retrospective study of patients with RRMS enrolling on 13 single-agent phase II Children's Oncology Group and legacy group trials from 1997 to 2016...
April 16, 2024: Pediatric Blood & Cancer
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JOURNAL ARTICLE
Lucia Martin-Gutierrez, Kirsty E Waddington, Annalisa Maggio, Leda Coelewij, Alexandra Oppong, Nina Yang, Marsilio Adriani, Petra Nytrova, Rachel Farrell, Inés Pineda-Torra, Elizabeth C Jury
Altered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (RRMS) and are linked to disease progression and treatment responses. CD4+ T cells are pathogenic in RRMS, and defective T cell function could be mediated in part by liver X receptors (LXRs) - nuclear receptors that regulate lipid homeostasis and immunity. RNA-sequencing and pathway analysis identified that genes within the 'lipid metabolism' and 'signalling of nuclear receptors' pathways were dysregulated in CD4+ T cells isolated from RRMS patients compared with healthy donors...
April 16, 2024: Clinical and Experimental Immunology
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JOURNAL ARTICLE
Andrijana Bogoje Raspopović, Vedran Balta, Maro Vodopić, Marina Drobac, Almoš Boroš, Domagoj Đikić, Vida Demarin
Oxidative stress markers have a distinct role in the process of demyelination in multiple sclerosis. This study investigated the potential correlation of markers of oxidative stress (glutathione [GSH], catalase) with the number of demyelinating lesions and the degree of disability, cognitive deficit, and depression in patients with relapsing-remitting multiple sclerosis (RRMS). Sixty subjects meeting the criteria for RRMS (19 men and 41 women), and 66 healthy controls (24 men, 42 women) were included. In this study, GSH significantly negatively correlated with the degree of cognitive impairment...
2024: Open Medicine (Warsaw, Poland)
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JOURNAL ARTICLE
Ralf Gold, Stephan Schmidt, Florian Deisenhammer, Jeremias Motte, Nils Richter, Kirsi Taipale, Hans Christian Salmen, Christian Bohland, Ksenija Schirduan
BACKGROUND: The consideration of patient preference for a certain drug route of administration (RoA) plays an important role in promoting patient adherence in chronic diseases. Natalizumab is an established treatment for relapsing-remitting multiple sclerosis (RRMS) and can be administered as intravenous (IV) infusion or subcutaneous (SC) injection developed to enable a shorter and easier administration versus IV RoA. STUDY OBJECTIVES: Primary objective is to compare patients' preference for RoA and satisfaction with SC versus IV natalizumab at baseline and subsequent visits up to 12 months...
2024: Therapeutic Advances in Neurological Disorders
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JOURNAL ARTICLE
Nermin R Abdelwahab, Randa R Mabrouk, Nahla M Zakaria, Azza Abdel Nasser, Afaf A Mostafa, Nancy S Wahba
One of the most common neurological illnesses in the world is multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS). MS has both a genetic and an environmental origin. In terms of environmental factors, vitamin D deficiency is one of the most important risk factors and closely connected with gene polymorphisms involved in vitamin D metabolism, transport, or activity. Since vitamin D activity requires a receptor-mediated response, any changes to the vitamin D receptor (VDR) may have an effect on the pathophysiology of the disease...
April 2024: Egyptian Journal of Immunology
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REVIEW
Athina Andravizou, Sotiria Stavropoulou De Lorenzo, Evangelia Kesidou, Iliana Michailidou, Dimitrios Parissis, Marina-Kleopatra Boziki, Polyxeni Stamati, Christos Bakirtzis, Nikolaos Grigoriadis
Choroid plexus (CP) can be seen as a watchtower of the central nervous system (CNS) that actively regulates CNS homeostasis. A growing body of literature suggests that CP alterations are involved in the pathogenesis of multiple sclerosis (MS) but the underlying mechanisms remain elusive. CPs are enlarged and inflamed in relapsing-remitting (RRMS) but also in clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) stages, far beyond MS diagnosis. Increases in the choroid plexus/total intracranial volume (CP/TIV) ratio have been robustly associated with increased lesion load, higher translocator protein (TSPO) uptake in normal-appearing white matter (NAWM) and thalami, as well as with higher annual relapse rate and disability progression in highly active RRMS individuals, but not in progressive MS...
April 1, 2024: Healthcare (Basel, Switzerland)
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JOURNAL ARTICLE
Maged Abdel Naseer, Hatem Samir Shehata, Sarah Khalil, Amr Mohamed Fouad, Hend Abdelghany
BACKGROUND: Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system. It is characterized by symptoms such as visual disturbances, paresis with spasticity, paresthesia, numbness, and fatigue. However, several studies have shown a high prevalence of headaches in individuals with MS. Migraine and tension-type headaches are the most frequent types of headaches experienced by those with MS. Additionally, the role of MS disease-modifying agents must be considered...
April 3, 2024: Multiple Sclerosis and related Disorders
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JOURNAL ARTICLE
Juan Luis Chico-Garcia, Raquel Sainz-Amo, Enric Monreal, Fernando Rodriguez-Jorge, Susana Sainz de la Maza, Jaime Masjuan, Luisa María Villar, Lucienne Costa-Frossard França
INTRODUCTION: Continuously acquired smartphone keyboard interactions may be useful to monitor progression in multiple sclerosis (MS). We aimed to study the correlation between tapping speed (TS), measured as keys/s, and baseline disability scales in patients with MS. METHODS: Single-center prospective study in patients with MS. We passively assessed TS during first week, measured by an "in house" smartphone application. Reliability was assessed by intraclass correlation coefficient (ICC)...
March 30, 2024: Multiple Sclerosis and related Disorders
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JOURNAL ARTICLE
Ayla Tekin, Buket Rende, Hüsnü Efendi, Sena Destan Bunul, Özgür Çakır, Tuncay Çolak, Sibel Balcı
Introduction Multiple sclerosis (MS) is a chronic and autoimmune disease that has a significant influence on the central nervous system, such as the brain and spinal cord, affecting millions of individuals globally. Understanding the connection between subcortical brain regions and MS is crucial for effective diagnostic and therapeutic approaches for treating this disabling disease. This study explores the relationship between volume and contours of asymmetry index of subcortical brain regions in individuals with MS using volBrain software (https://www...
March 2024: Curēus
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REVIEW
Wendy Wu, Heather Francis, Abbie Lucien, Tyler-Ann Wheeler, Milena Gandy
It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-remitting multiple sclerosis and are associated with adverse functional consequences. However, estimates of cognitive impairment (CIm) prevalence vary widely. This study aimed to determine the pooled prevalence of CIm among adults with RRMS and investigate moderators of prevalence rates. Following prospective registration (PROSPERO; CRD42021281815), electronic databases (Embase, Scopus, Medline, and PsycINFO) were searched from inception until March 2023...
April 8, 2024: Neuropsychology Review
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JOURNAL ARTICLE
Shirin Mavandadi, Sepideh Paybast, Monirsadat Mirzadeh, Hossein Mozhdehipanah
INTRODUCTION: Fatigue is a highly prevalent debilitating symptom among patients with multiple sclerosis (PwMS), which markedly affects the quality of life. The present study aimed to evaluate the effect of extended-release fampridine on fatigue in PwMS. METHODS: This was a randomized, double-blind clinical trial on 77 PwMS with a complaint of fatigue, aged over 18 years old, randomized to extended-release fampridine (n = 44) or placebo (n = 35) for 12 weeks...
April 6, 2024: Acta Neurologica Belgica
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JOURNAL ARTICLE
Melis Buse Altun, Özlem Öge-Daşdöğen, Melih Tütüncü
Verbal fluency (VF) evaluates language and cognitive abilities. This study compared VF in Relapsing-Remitting Multiple Sclerosis (RRMS) and healthy controls (HC), examining variables including correct responses (CR), mean cluster size (MCS), switches (S), and fluency difference score (FDS). RRMS participants were subgrouped by Expanded Disability Status Scale (EDSS), to explore the relationship between MS severity and VF. Twenty-four RRMS participants and matched HCs underwent Mini-Mental State Exam and VF Test...
April 4, 2024: Applied Neuropsychology. Adult
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JOURNAL ARTICLE
Cathérine Dekeyser, Matthias Hautekeete, Melissa Cambron, Vincent Van Pesch, Francesco Patti, Jens Kuhle, Samia Khoury, Jeanette Lechner Scott, Oliver Gerlach, Alessandra Lugaresi, Davide Maimone, Andrea Surcinelli, Pierre Grammond, Tomas Kalincik, Mario Habek, Barbara Willekens, Richard Macdonell, Patrice Lalive, Tunde Csepany, Helmut Butzkueven, Cavit Boz, Valentina Tomassini, Matteo Foschi, José Luis Sánchez-Menoyo, Ayse Altintas, Saloua Mrabet, Gerardo Iuliano, Maria Jose Sa, Raed Alroughani, Rana Karabudak, Eduardo Aguera-Morales, Orla Gray, Koen de Gans, Anneke van der Walt, Pamela A McCombe, Norma Deri, Justin Garber, Abdullah Al-Asmi, Olga Skibina, Pierre Duquette, Elisabetta Cartechini, Daniele Spitaleri, Riadh Gouider, Aysun Soysal, Liesbeth Van Hijfte, Mark Slee, Maria Pia Amato, Katherine Buzzard, Guy Laureys
BACKGROUND: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. METHODS: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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JOURNAL ARTICLE
E Signoriello, M Foschi, R Lanzillo, J Frau, E Cocco, G Borriello, A Ianniello, M Trotta, D Landi, G T Maniscalco, F Ruscica, S Toscano, F Patti, A Zanghì, E D'Amico, R Fantozzi, D Centonze, G Lus, S Bonavita
INTRODUCTION: Cladribine is an oral immune reconstitution therapy for relapsing multiple sclerosis (RMS). Hormonal and immune changes are responsible for the decline of disease activity in the third trimester of pregnancy and disease reactivation in the early post-partum period.We investigate the impact of pregnancy on disease activity in women with MS who conceived after cladribine treatment. METHODS: We recruited women of childbearing age with relapsing-remitting MS (RRMS) who became pregnant or not after being treated with cladribine...
April 3, 2024: Journal of Neurology
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JOURNAL ARTICLE
Naiduwadura Ivon Upekala De Silva, Nathan Lehman, Talia Fargason, Trenton Paul, Zihan Zhang, Jun Zhang
SRSF1 governs splicing of over 1500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded exonic splicing enhancers, while RS lacks RNA-binding specificity. With our success in solving the insolubility problem of SRSF1, we can explore the unknown RNA-binding landscape of SRSF1. We find that SRSF1 RS prefers purine over pyrimidine. Moreover, SRSF1 binds to the G-quadruplex (GQ) from the ARPC2 mRNA, with both RRMs and RS being crucial...
April 3, 2024: Nucleic Acids Research
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JOURNAL ARTICLE
Hongmei Tan, Xiang Li, Yuxin Li, Fanru He, Jingzi ZhangBao, Lei Zhou, Liqin Yang, Chongbo Zhao, Chuanzhen Lu, Qiang Dong, Haiqing Li, Chao Quan
OBJECTIVES: The aims of this study were to report the effectiveness and safety of teriflunomide in Chinese patients with relapsing-remitting multiple sclerosis (RRMS) and to explore the association of paramagnetic rim lesion (PRL) burden with patient outcome in the context of teriflunomide treatment and the impact of teriflunomide on PRL burden. METHODS: This is a prospective observational study. A total of 100 RRMS patients treated with teriflunomide ≥3 months were included in analyzing drug persistence and safety...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Tiantian Hua, Houyou Fan, Yunyun Duan, Decai Tian, Zhenpeng Chen, Xiaolu Xu, Yutong Bai, Yuna Li, Ningnannan Zhang, Jie Sun, Haiqing Li, Yuxin Li, Yongmei Li, Chun Zeng, Xuemei Han, Fuqing Zhou, Muhua Huang, Siyao Xu, Ying Jin, Hongfang Li, Zhizheng Zhuo, Xinghu Zhang, Yaou Liu
BACKGROUND: Spinal cord and brain atrophy are common in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) but harbor distinct patterns accounting for disability and cognitive impairment. METHODS: This study included 209 NMOSD and 304 RRMS patients and 436 healthy controls. Non-negative matrix factorization was used to parse differences in spinal cord and brain atrophy at subject level into distinct patterns based on structural MRI...
April 1, 2024: Journal of Neurology
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