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https://www.readbyqxmd.com/read/28944807/conjugated-fatty-acid-rich-oil-from-gynostrmma-pentaphyllum-seed-can-ameliorate-lipid-and-glucose-metabolism-in-type-2-diabetes-mellitus-mice
#1
Mingxing Zhang, Nan Du, Lu Wang, Xiaobing Wang, Yaping Xiao, Kun Zhang, Quanhong Liu, Pan Wang
Gynostrmma pentaphyllum seed oil (GPSO), extracted from G. pentaphyllum seeds, is rich in conjugated linolenic acid, which is a special fatty acid consisting of cis-9, trans-11, trans-13 isomers. Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from insulin resistance, and is usually accompanied by hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic syndrome, or syndrome X), and polycystic ovarian disease. This study aimed to investigate the effect of GPSO on T2DM hepatic lipid metabolism and the underlying mechanism involving level of protein expression...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944242/autosomal-recessive-long-qt-syndrome-type-1-in-eight-families-from-saudi-arabia
#2
Amnah Y Bdier, Saleh Al-Ghamdi, Prashant K Verma, Khalid Dagriri, Bandar Alshehri, Omamah A Jiman, Sherif E Ahmed, Arthur A M Wilde, Zahurul A Bhuiyan, Jumana Y Al-Aama
BACKGROUND: One of the most common primary cardiac arrhythmia syndromes is autosomal dominant long QT syndrome, type 1 (LQT1), chiefly caused by mono-allelic mutations in the KCNQ1 gene. Bi-allelic mutations in the KCNQ1 gene are causal to Jervell and Lange-Nielsen syndrome (JLNS), characterized by severe and early-onset arrhythmias with prolonged QTc interval on surface ECG and sensorineural deafness. Occasionally, bi-allelic mutations in KCNQ1 are also found in patients without any deafness, referred to as autosomal recessive long QT syndrome, type 1 (AR LQT1)...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944140/mucopolysaccharidosis-type-i-ii-and-vi-and-response-to-enzyme-replacement-therapy-results-from-a-single-center-case-series-study
#3
José Francisco da Silva Franco, Regina El Dib, Arnav Agarwal, Diogo Soares, Noala Vicensoto Moreira Milhan, Lilian Maria José Albano, Chong Ae Kim
Mucopolysaccharidoses (MPS) types I, II and VI are associated with deficiencies in alpha-L-iduronidase, iduronate-2-sulfatase and N-acetylgalactosamine-4-sulfatase, respectively, and generally involve progressive and multi-systemic clinical manifestations. Enzyme replacement therapy (ERT) appears to be reasonably well tolerated. The aim of this study was to examine clinical and diagnostic findings of a series of pediatric and adult MPS patients, and assess the safety and efficacy of ERT in children and adults with MPS type I, II and VI...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943668/acetone-promoted-1-4-migration-of-an-alkoxycarbonyl-group-on-a-syn-1-2-diamine
#4
Tanya Napolitano, Shu-Yuan Cheng, Brooke Nielsen, Christopher Choi, William Aguilar, Manuel M Paz, Anne-Marie Sapse, Elise Champeil
A 2-protected cis-amino mitosene undergoes an irreversible acetone promoted isomerization and converts to the 1-isomer. Kinetic studies and DFT calculations of the reaction are reported. An organocatalytic mechanism is proposed, involving a covalent intermediate formed by reaction of the mitosene and acetone.
February 15, 2017: Tetrahedron Letters
https://www.readbyqxmd.com/read/28943044/prolyl-isomerase-pin1-promotes-proplatelet-formation-of-megakaryocytes-via-tau
#5
Taiki Shimizu, Chiyoko Uchida, Ritsuko Shimizu, Hozumi Motohashi, Takafumi Uchida
Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene (Pin1(-⁄-) mice) formed more megakaryocytes (MKs) than wild type mice (WT mice), and that the proplatelet formation of MKs was poorer in Pin1(-⁄-) mice than WT mice. Treatment of Meg-01 cells, a megakaryoblastic floating cell line, with shRNA against Pin1 suppressed the proplatelet formation. Expression of tau, a microtubule associated protein was induced in MKs during proplatelet formation...
September 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942832/chemical-composition-antioxidant-and-antibacterial-activity-of-essential-oils-from-etlingera-sayapensis-a-d-poulsen-ibrahim
#6
Behnam Mahdavi, Wan A Yaacob, Laily B Din
OBJECTIVE: To report the chemical composition and bioactivity (including antioxidant and antimicrobial activity) of essential oils from the rhizomes, stems, and leaves of Etlingera sayapensis (E. sayapensis) A.D. Poulsen & Ibrahim for the first time. METHODS: First, the essential oils were obtained using a Clevenger-type apparatus. Then, the essential oils compositions were identified by chromatography methods including GC-FID and GC-MS. For the next step, DPPH radical scavenging activity (RSA), β-carotene bleaching (BCB), and ferrous ion chelating ability (FIC) were chosen to evaluate the essential oils antioxidant activity...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942695/ovarian-stimulation-under-the-effect-of-isotretinoin
#7
Mauro Cozzolino, Javier Domingo, Sérgio Reis Soares
Isotretinoin (13-cis-retinoic acid) is a pharmaceutical vitamin A analog that is frequently used in the treatment of severe cystic acne, many women at reproductive age being exposed to this substance. This drug has a clearly documented teratogenicity and data from rodents and humans indicate that a direct aggression to ovarian follicles also occurs. Here we report the case of a 29-year-old woman with breast cancer referred for emergency preservation of reproductive potential that used isotretinoin up to the day before the initiation of ovarian stimulation...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942673/concussion-nondisclosure-during-professional-career-among-a-cohort-of-former-national-football-league-athletes
#8
Zachary Y Kerr, Johna K Register-Mihalik, Melissa C Kay, J D DeFreese, Stephen W Marshall, Kevin M Guskiewicz
BACKGROUND: Despite a focus on the incidence and effects of concussion, nondisclosure of sports-related concussions among retired players from the National Football League (NFL) has yet to be examined. PURPOSE: Examine the prevalence of and factors associated with nondisclosure of sports-related concussions in former NFL athletes. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: A sample of 829 former NFL players completed a general health survey...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28942635/degradation-of-crude-4-mchm-4-methylcyclohexanemethanol-in-sediments-from-elk-river-west-virginia
#9
Isabelle M Cozzarelli, Denise M Akob, Mary Jo Baedecker, Tracey Spencer, Jeanne Jaeschke, Darren S Dunlap, Adam C Mumford, Amisha T Poret-Peterson, Douglas B Chambers
In January 2014, approximately 37,800 L of crude 4-methylcyclohexanemethanol (crude MCHM) spilled into the Elk River, West Virginia. To understand the long-term fate of 4-MCHM, we conducted experiments under environmentally relevant conditions to assess the potential for the 2 primary compounds in crude MCHM (1) to undergo biodegradation and (2) for sediments to serve as a long-term source of 4-MCHM. We developed a solid phase micro-extraction (SPME) method to quantify the cis- and trans- isomers of 4-MCHM...
September 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28942241/long-non-coding-rna-hoxa11-as-in-human-cancer-a-meta-analysis
#10
REVIEW
Na Li, Meilan Yang, Ke Shi, Wei Li
BACKGROUND: Homeobox A11 antisense (HOXA11-AS), a newly identified lncRNA, is up-regulated in various carcinomas. We conducted the present meta-analysis to explore the potential of HOXA11-AS as a common predictive biomarker for metastasis and prognosis in malignant tumors. METHODS: A systematic literature search on the online electronic databases of PubMed, Web of Science, and Embase was carried out to determine relevant studies (as of July 9, 2017). The pooled hazard ratios (HRs)/odds rates (ORs), and their 95% confidence intervals (CIs) were used to evaluate the relationship...
September 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28942160/gold-nanoconjugates-reinforce-the-potency-of-conjugated-cisplatin-and-doxorubicin
#11
Sana Iram, Manaal Zahera, Salman Khan, Imran Khan, Asad Syed, Abu Ayoobul Ansary, Fuad Ameen, Omar H M Shair, Mohd Sajid Khan
Osteosarcoma or osteogenic sarcoma is the most common and prevalent cancerous tumor of bone and occurs especially in children and teens. Recent treatment strategy includes a combination of both chemotherapy and surgeries. Although, the use of single drug-based chemotherapy treatment remains unsatisfactory. Therefore, combinatorial therapy has emerged as a potential strategy for treatment with limited side- effects. Here, we evaluated the combinatorial anticancerous effect of cisplatin (CIS) and doxorubicin (DOX) bioconjugated bromelain encapsulated gold nanoparticles (B-AuNPs conjugated CIS and DOX) in the treatment of osteosarcoma...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28941601/refining-prediction-of-atrial-fibrillation-risk-in-the-general-population-with-analysis-of-p-wave-axis-from-the-atherosclerosis-risk-in-communities-study
#12
Ankit Maheshwari, Faye L Norby, Elsayed Z Soliman, Ryan Koene, Mary Rooney, Wesley T O'Neal, Alvaro Alonso, Lin Y Chen
Adverse atrial remodeling is associated with increased risk of atrial fibrillation (AF) and can be detected by a shift in P-wave axis. We aimed to determine whether an analysis of P-wave axis can be used to improve risk prediction of AF. We included 15,102 Atherosclerosis Risk in Communities Study participants who were free of AF at baseline. Abnormal P-wave axis (aPWA) was defined as any value outside 0 to 75 degrees on study visit 12-lead electrocardiograms. AF was determined using study visit electrocardiograms, death certificates, and hospital discharge records...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28941403/dual-function-of-a-cis-acting-rna-element-that-acts-as-a-replication-enhancer-and-a-translation-repressor-in-a-plant-positive-stranded-rna-virus
#13
Kiwamu Hyodo, Hikari Nagai, Tetsuro Okuno
The genome of red clover necrotic mosaic virus is divided into two positive-stranded RNA molecules of RNA1 and RNA2, which have no 5' cap structure and no 3' poly(A) tail. Previously, we showed that any mutations in the cis-acting RNA replication elements of RNA2 abolished its cap-independent translational activity, suggesting a strong link between RNA replication and translation. Here, we investigated the functions of the 5' untranslated region (UTR) of RNA2 and revealed that the basal stem-structure (5'BS) predicted in the 5' UTR is essential for robust RNA replication...
September 20, 2017: Virology
https://www.readbyqxmd.com/read/28941222/nonsteroidal-anti-inflammatory-drugs-nsaids-and-prostate-cancer-risk-results-from-the-epicap-study
#14
Solene Doat, Sylvie Cénée, Brigitte Trétarre, Xavier Rebillard, Pierre-Jean Lamy, Jean-Pierre Bringer, François Iborra, Thibaut Murez, Marie Sanchez, Florence Menegaux
Chronic inflammation may play a role in prostate cancer carcinogenesis. In that context, our objective was to investigate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in prostate cancer risk based on the EPICAP data. EPICAP is a population-based case-control study carried out in 2012-2013 (département of Hérault, France) that enrolled 819 men aged less than 75 years old newly diagnosed for prostate cancer and 879 controls frequency matched to the cases on age. Face to face interviews gathered information on several potential risk factors including NSAIDs use...
September 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28941200/decreased-neuro-axonal-proteins-in-csf-at-first-attack-of-suspected-multiple-sclerosis
#15
Marcel P Stoop, Tessel F Runia, Christoph Stingl, Roos M van der Vuurst de Vries, Theo M Luider, Rogier Q Hintzen
PURPOSE: The pathology of multiple sclerosis is located in the central nervous system, therefore cerebrospinal fluid (CSF) is an attractive biofluid for biomarker research for proteins related to the early stages of this disease. In this study, the CSF proteome of patients with a Clinically Isolated Syndrome of demyelination (CIS, a first attack of Multiple Sclerosis) was compared to the CSF proteome of control patients to identify differentially abundant proteins. EXPERIMENTAL DESIGN: CSF samples of 47 CIS patients and 45 control subjects were enzymatically digested and subsequently measured by LC-MS/MS (LTQ-Orbitrap)...
September 20, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28941018/role-of-non-coding-rnas-in-head-and-neck-squamous-cell-carcinoma-a-narrative-review
#16
REVIEW
M K Sannigrahi, Rajni Sharma, Naresh K Panda, Madhu Khullar
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides), responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor-suppressors miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and, have been also implicated in carcinogenesis...
September 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28940770/a-solid-iridium-catalyst-for-diastereoselective-hydrogenation
#17
Iuliia Romanenko, Louis Jaffeux, Laurent Veyre, Emmanuel Lacôte, Valérie Meille, Chloé Thieuleux
An Ir(NHC) supported catalyst is used in the selective hydrogenation of terpinen-4-ol to cis p-menthan-4-ol. Its activity, selectivity and stability are compared to those of a homogeneous homologue [IrCl(COD)MesImPr] and to a commercial Pd/C. The solid Ir catalyst is much more selective than the Pd catalyst (92 vs. 42% at 80°C) but also more active, more selective and more stable than the iridium complex in solution. For the first time, a supported catalyst shows an enhanced activity with respect to a complex in a diastereoselective hydrogenation reaction...
September 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28940633/programmable-glycan-presentation-of-glycodendrimersomes-and-cells-react-with-engineered-human-lectins-to-unveil-cell-surface-sugar-functionality
#18
Jürgen Kopitz, Qi Xiao, Anna-Kristin Ludwig, Antonio Romero, Malwina Michalak, Samuel E Sherman, Xuhao Zhou, Cody Dazen, Sabine Vértesy, Herbert Kaltner, Michael L Klein, Hans-Joachim Gabius, Virgil Percec
Chemical and biological tools are harnessed to investigate the impact of spatial factors for functional pairing of human lectins with counterreceptors. The homodimeric adhesion/growth-regulatory galectin-1 and a set of covalently linked homo-oligomers from di- to tetramers serve as proof-of-principle test cases. Glycodendrimersomes provide a versatile and sensitive diagnostic platform to reveal thresholds for ligand density and protein concentration in aggregation assays (trans-activity), irrespective of linker length between lectin domains...
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28940619/eruptive-milia-during-isotretinoin-therapy
#19
William Farmer, Kyle Cheng, Kalyani Marathe
Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative that is effective in the treatment of recalcitrant, nodulocystic acne. To our knowledge, there are no reports in the medical literature of milia as a side effect of isotretinoin. We report a case of eruptive facial milia in the setting of isotretinoin treatment for acne.
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28940573/positive-regulation-of-ams-by-tdf1-and-the-formation-of-a-tdf1-ams-complex-are-required-for-anther-development-in-arabidopsis-thaliana
#20
Yue Lou, Hai-Sheng Zhou, Yu Han, Qiu-Ye Zeng, Jun Zhu, Zhong-Nan Yang
Tapetum development and pollen production are regulated by a complex transcriptional network that consists of a group of tapetum-specific Arabidopsis transcription factors (TFs). Among these TFs, DEFECTIVE IN TAPETAL DEVELOPMENT AND FUNCTION 1 (TDF1) encodes an R2R3 MYB factor, and ABORTED MICROSPORE (AMS) encodes a basic helix-loop-helix (bHLH) factor. However, knowledge regarding the regulatory role of TDF1 in anther development remains limited. Here, we discovered that TDF1 directly regulates AMS via an AACCT cis-element...
September 20, 2017: New Phytologist
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