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https://www.readbyqxmd.com/read/29145527/evaluation-of-operating-time-and-patient-perception-using-conventional-impression-taking-and-intraoral-scanning-for-crown-manufacture-a-split-mouth-randomized-clinical-study
#1
Yasser Haddadi, Golnosh Bahrami, Flemming Isidor
PURPOSE: To compare operating time and patient perception of conventional impression (CI) taking and intraoral scanning (IOS) for manufacture of a tooth-supported crown. MATERIALS AND METHODS: A total of 19 patients needing indirect full-coverage restorations fitting the requirements for a split-mouth design were recruited. Each patient received two lithium disilicate crowns, one manufactured from CI taking and one from IOS. Both teeth were prepared following the manufacturers' recommendations...
November 16, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29145506/the-prpf-protein-of-shewanella-oneidensis-mr-1-catalyzes-the-isomerization-of-2-methyl-cis-aconitate-during-the-catabolism-of-propionate-via-the-acnd-dependent-2-methylcitric-acid-cycle
#2
Christopher J Rocco, Karl M Wetterhorn, Graeme S Garvey, Ivan Rayment, Jorge C Escalante-Semerena
The 2-methylcitric acid cycle (2-MCC) is a common route of propionate catabolism in microorganisms. In Salmonella enterica, the prpBCDE operon encodes most of the 2-MCC enzymes. In other organisms, e.g., Shewanella oneidensis MR-1, two genes, acnD and prpF replace prpD, which encodes 2-methylcitrate dehydratase. We showed that together, S. oneidensis AcnD and PrpF (SoAcnD, SoPrpF) compensated for the absence of PrpD in a S. enterica prpD strain. We also showed that SoAcnD had 2-methylcitrate dehydratase activity and that PrpF has aconitate isomerase activity...
2017: PloS One
https://www.readbyqxmd.com/read/29145496/insights-into-soybean-transcriptome-reconfiguration-under-hypoxic-stress-functional-regulatory-structural-and-compositional-characterization
#3
Thiago J Nakayama, Fabiana A Rodrigues, Norman Neumaier, Juliana Marcolino-Gomes, Hugo B C Molinari, Thaís R Santiago, Eduardo F Formighieri, Marcos F Basso, José R B Farias, Beatriz M Emygdio, Ana C B de Oliveira, Ângela D Campos, Aluízio Borém, Frank G Harmon, Liliane M Mertz-Henning, Alexandre L Nepomuceno
Soybean (Glycine max) is one of the major crops worldwide and flooding stress affects the production and expansion of cultivated areas. Oxygen is essential for mitochondrial aerobic respiration to supply the energy demand of plant cells. Because oxygen diffusion in water is 10,000 times lower than in air, partial (hypoxic) or total (anoxic) oxygen deficiency is important component of flooding. Even when oxygen is externally available, oxygen deficiency frequently occurs in bulky, dense or metabolically active tissues such as phloem, meristems, seeds, and fruits...
2017: PloS One
https://www.readbyqxmd.com/read/29145326/should-fraction-flow-reserve-be-considered-an-important-decision-making-tool-to-stratify-patients-with-stable-coronary-artery-disease-for-percutaneous-coronary-intervention-a-meta-analysis
#4
Pravesh Kumar Bundhun, Chakshu Gupta, Feng Huang
BACKGROUND: Nowadays, fraction flow reserve (FFR) is being discussed in every percutaneous coronary intervention (PCI) capable hospitals. Owing to recent development in the medical field, FFR-guided PCI should be able to find a place in Interventional Cardiology. At present, the importance of FFR to stratify patients who require PCI has seldom systematically been investigated. In this analysis, we aimed to compare the major adverse cardiac events (MACEs) mainly in patients with stable coronary artery disease (CAD) to whom PCI was recommended and deferred respectively based on the FFR value...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144893/primary-care-providers-level-of-preparedness-for-recommending-physical-activity-to-adults-with-disabilities
#5
Elizabeth A Courtney-Long, Alissa C Stevens, Dianna D Carroll, Shannon Griffin-Blake, John D Omura, Susan A Carlson
INTRODUCTION: Adults with disabilities are more likely to be physically inactive than those without disabilities. Although receiving a health care provider recommendation is associated with physical activity participation in this population, there is little information on factors associated with primary care providers recommending physical activity to patients with disabilities. METHODS: We used 2014 DocStyles data to assess primary care provider characteristics and perceived barriers to and knowledge-related factors of recommending physical activity to adult patients with disabilities, by how prepared primary care providers felt in making recommendations...
November 16, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29144549/zuclopenthixol-dihydrochloride-for-schizophrenia
#6
REVIEW
Edward J Bryan, Marie Ann Purcell, Ajit Kumar
BACKGROUND: Oral zuclopenthixol dihydrochloride (Clopixol) is an anti-psychotic treatment for people with psychotic symptoms, especially those with schizophrenia. It is associated with neuroleptic malignant syndrome, a prolongation of the QTc interval, extra-pyramidal reactions, venous thromboembolism and may modify insulin and glucose responses. OBJECTIVES: To determine the effects of zuclopenthixol dihydrochloride for treatment of schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (latest search 09 June 2015)...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29144545/music-therapy-for-depression
#7
REVIEW
Sonja Aalbers, Laura Fusar-Poli, Ruth E Freeman, Marinus Spreen, Johannes Cf Ket, Annemiek C Vink, Anna Maratos, Mike Crawford, Xi-Jing Chen, Christian Gold
BACKGROUND: Depression is a highly prevalent mood disorder that is characterised by persistent low mood, diminished interest, and loss of pleasure. Music therapy may be helpful in modulating moods and emotions. An update of the 2008 Cochrane review was needed to improve knowledge on effects of music therapy for depression. OBJECTIVES: 1. To assess effects of music therapy for depression in people of any age compared with treatment as usual (TAU) and psychological, pharmacological, and/or other therapies...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29144404/dietary-magnesium-and-incident-frailty-in-older-people-at-risk-for-knee-osteoarthritis-an-eight-year-longitudinal-study
#8
Nicola Veronese, Brendon Stubbs, Stefania Maggi, Maria Notarnicola, Mario Barbagallo, Joseph Firth, Ligia J Dominguez, Maria Gabriella Caruso
Inadequate magnesium (Mg) intake is associated with lower physical performance, but the relationship with frailty in older people is unclear. Therefore, we aimed to investigate whether higher dietary Mg intake is associated with a lower risk of frailty in a large cohort of North American individuals. Details regarding Mg intake were recorded through a food-frequency questionnaire (FFQ) and categorized as greater than/equal to Recommended Dietary Allowance (RDA) vs. lower. Frailty was defined using the Study of Osteoporotic Fractures index...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29144170/night-work-as-a-risk-factor-for-future-cause-specific-disability-pension-a-prospective-twin-cohort-study-in-sweden
#9
Annina Ropponen, Jurgita Narusyte, Lisa Mather, Ellenor Mittendorfer-Rutz, Torbjörn Åkerstedt, Pia Svedberg
The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-1958 that were linked with DP data for the survey period (1998-2003) to 2013. Night work was assessed as years of working nights at least every now and then, and categorized into not at all, 1-10 years and over 10 years...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29144141/experimental-demonstration-of-a-sizeable-nonclassical-ch%C3%A2-%C3%A2-%C3%A2-g-hydrogen-bond-in-cyclohexane-derivatives-stabilization-of-an-axial-cyano-group
#10
Kyle M Lambert, Zachary D Stempel, Kenneth B Wiberg, William F Bailey
Base-catalyzed equilibration of anancomeric cyanocyclohexanes demonstrates that replacement of cis-3,5-dimethyl holding groups with electron-withdrawing CF3 groups dramatically increases the proportion of the axial cyano isomer present at equilibrium. The CF3 groups exert an effect on the conformational energy of the cyano group worth about 0.6 kcal/mol. A nonclassical hydrogen bond between the axial CN group and the syn-axial hydrogens is a major contributor to the axial stability of the group.
November 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29144123/the-sign-of-nmr-chemical-shift-difference-as-a-determinant-of-the-origin-of-binding-selectivity-elucidation-of-the-position-dependence-of-phosphorylation-in-ligands-binding-to-scribble-pdz1
#11
Gustav Sundell, Beat Vögeli, Ylva Ivarsson, Celestine Chi
The use of NMR chemical shift perturbation to monitor changes taking place around the binding site of a ligand-protein interaction is a routine and widely applied methodology in the field of protein biochemistry. Shifts are often acquired by titrating various concentrations of ligand to a fixed concentration of the receptor and may serve the purposes, amongst others, to determine affinity constants, locate binding surfaces, or differentiate between binding mechanisms. Shifts are quantified by the so-called combined chemical shift difference...
November 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/29143562/pathological-cut-offs-of-global-and-regional-brain-volume-loss-in-multiple-sclerosis
#12
Tomas Uher, Manuela Vaneckova, Jan Krasensky, Lukas Sobisek, Michaela Tyblova, Jana Volna, Zdenek Seidl, Niels Bergsland, Michael G Dwyer, Robert Zivadinov, Nicola De Stefano, Maria Pia Sormani, Eva Kubala Havrdova, Dana Horakova
BACKGROUND: Volumetric MRI surrogate markers of disease progression are lacking. OBJECTIVE: To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. METHODS: In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29143424/restoration-of-ribozyme-tertiary-contact-and-function-using-a-molecular-glue-for-rna
#13
Chikara Dohno, Maki Kimura, Kazuhiko Nakatani
Some RNA classes require folding into the proper higher-order structures to exert their functions. Hammerhead ribozyme (HHR) requires a folding conformation stabilized by tertiary interaction for full activity. Here, we developed a rationally engineered HHR that was inactive, but could be activated by a synthetic RNA-binding ligand, naphthyridine carbamate tetramer with Z-stilbene linker (Z-NCTS). Binding of Z-NCTS could induce the formation of an active folding structure and thereby restore ribozyme activity, where Z-NCTS acts as a molecular glue to bring two isolated RNA loops into contact with each other...
November 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29142824/system-wide-cofactor-turnovers-can-propagate-metabolic-stability-between-pathways
#14
Y Yang, Y H Guan, J Villadsen
Metabolic homeostasis, or low-level metabolic steady state, has long been taken for granted in metabolic engineering, and research priority has always been given to understand metabolic flux control and regulation of the reaction network. In the past, this has not caused concerns because the metabolic networks studied were invariably associated with living cells. Nowadays, there are needs to reconstruct metabolic networks, and so metabolic homeostasis cannot be taken for granted. For metabolic steady state, enzyme feedback control has been known to explain why metabolites in metabolic pathways can avoid accumulation...
December 2016: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29142555/exclusive-breastfeeding-practices-in-working-women-of-pakistan-a-cross-sectional-study
#15
Aroona Sabin, Farida Manzur, Saleem Adil
Objective: To determine the prevalence of exclusive breast feeding in working women and to identify the factors effecting exclusive breast feeding in working women. Methods: This cross-sectional survey was conducted in Faisalabad city within a period of six months from June 2016 to December 2016. Working women of age 18 to 45 years, working as doctors, teachers, nurses and bankers in public (government) setup were included. The data was collected using interview method by pre-structured questionnaire...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142551/association-of-single-nucleotide-missence-polymorphism-val109asp-of-omentin-1-gene-and-coronary-artery-disease-in-pakistani-population-multicenter-study
#16
Shazia Nazar, Sitwat Zehra, Abid Azhar
Background & Objective: Coronary artery disease (CAD) is a most important cause of morbidity and mortality worldwide as well as in Pakistan. Recent studies have shown that the combination of obesity, insulin resistance and fluctuation in circulating adipocytokines levels is associated with the pathogenesis of coronary artery disease. Omentin-1 is recently found adipocytokine that is highly expressed in visceral adipose tissue. It has anti- inflammatory properties and is negatively correlated with ischemic heart disease...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142269/sex-specific-association-between-asthma-and-hypertension-in-nationally-representative-young-korean-adults
#17
Hong Seok Lee, Yong-Moon Park, Kyungdo Han, Gerald Pekler, Seong-Su Lee, Soonjib Yoo, Sung Rae Kim
It has been reported that people with asthma have an increased risk of hypertension. However, little is known about the specific relationship between asthma and hypertension in young adults. Among subjects who participated in the Korea National Health and Nutrition Examination Survey conducted in 2008-2013, a total of 10,138 young adults (4,226 men and 5,912 women) aged 19-39 years were analyzed. Multiple logistic regression analysis was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs)...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142228/genome-wide-mapping-of-genetic-determinants-influencing-dna-methylation-and-gene-expression-in-human-hippocampus
#18
Herbert Schulz, Ann-Kathrin Ruppert, Stefan Herms, Christiane Wolf, Nazanin Mirza-Schreiber, Oliver Stegle, Darina Czamara, Andreas J Forstner, Sugirthan Sivalingam, Susanne Schoch, Susanne Moebus, Benno Pütz, Axel Hillmer, Nadine Fricker, Hartmut Vatter, Bertram Müller-Myhsok, Markus M Nöthen, Albert J Becker, Per Hoffmann, Thomas Sander, Sven Cichon
Emerging evidence emphasizes the strong impact of regulatory genomic elements in neurodevelopmental processes and the complex pathways of brain disorders. The present genome-wide quantitative trait loci analyses explore the cis-regulatory effects of single-nucleotide polymorphisms (SNPs) on DNA methylation (meQTL) and gene expression (eQTL) in 110 human hippocampal biopsies. We identify cis-meQTLs at 14,118 CpG methylation sites and cis-eQTLs for 302 3'-mRNA transcripts of 288 genes. Hippocampal cis-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain eQTLs...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29141965/food-groups-and-risk-of-hypertension-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#19
REVIEW
Lukas Schwingshackl, Carolina Schwedhelm, Georg Hoffmann, Sven Knüppel, Khalid Iqbal, Violetta Andriolo, Angela Bechthold, Sabrina Schlesinger, Heiner Boeing
The aim of this systematic review and meta-analysis was to summarize the evidence on the relation of the intakes of 12 major food groups, including whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages (SSBs) with the risk of hypertension. PubMed, Scopus, and Web of Science were searched systematically until June 2017 for prospective studies having quantitatively investigated the above-mentioned foods. We conducted meta-analysis on the highest compared with the lowest intake categories and linear and nonlinear dose-response meta-analyses to analyze the association...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29141884/a-method-of-high-throughput-functional-evaluation-of-egfr-gene-variants-of-unknown-significance-in-cancer
#20
Shinji Kohsaka, Masaaki Nagano, Toshihide Ueno, Yoshiyuki Suehara, Takuo Hayashi, Naoko Shimada, Kazuhisa Takahashi, Kenji Suzuki, Kazuya Takamochi, Fumiyuki Takahashi, Hiroyuki Mano
Numerous variants of unknown significance (VUS) have been identified through large-scale cancer genome projects, although their functional relevance remains uninvestigated. We developed a mixed-all-nominated-mutants-in-one (MANO) method to evaluate the transforming potential and drug sensitivity of oncogene VUS in a high-throughput manner and applied this method to 101 nonsynonymous epidermal growth factor receptor (EGFR) mutants. We discovered a number of mutations conferring resistance to EGFR tyrosine kinase inhibitors (TKIs), including gefitinib- and erlotinib-insensitive missense mutations within exon 19 and other gefitinib-resistant mutations, such as L833V, A839T, V851I, A871T, and G873E...
November 15, 2017: Science Translational Medicine
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