keyword
MENU ▼
Read by QxMD icon Read
search

CIS

keyword
https://www.readbyqxmd.com/read/28749499/elucidating-nuclear-motions-in-a-plant-sunscreen-during-photoisomerization-through-solvent-viscosity-effects
#1
M D Horbury, W-D Quan, A L Flourat, F Allais, V G Stavros
We explore the effects of solvent viscosity on the trans-cis photoisomerization of sinapoyl malate, which is utilized as a sunscreen molecule in plants. Our results demonstrate that viscosity has a significant effect on the timescale for isomerization, providing insight into the nuclear motions involved. The ramifications of these findings are discussed with reference to sinapoyl malate's in vivo photoprotection properties.
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749477/mapping-the-genomic-landscape-of-inherited-retinal-disease-genes-prioritizes-genes-prone-to-coding-and-noncoding-copy-number-variations
#2
Kristof Van Schil, Sarah Naessens, Stijn Van de Sompele, Marjolein Carron, Alexander Aslanidis, Caroline Van Cauwenbergh, Anja Kathrin Mayer, Mattias Van Heetvelde, Miriam Bauwens, Hannah Verdin, Frauke Coppieters, Michael E Greenberg, Marty G Yang, Marcus Karlstetter, Thomas Langmann, Katleen De Preter, Susanne Kohl, Timothy J Cherry, Bart P Leroy, Elfride De Baere
PurposePart of the hidden genetic variation in heterogeneous genetic conditions such as inherited retinal diseases (IRDs) can be explained by copy-number variations (CNVs). Here, we explored the genomic landscape of IRD genes listed in RetNet to identify and prioritize those genes susceptible to CNV formation.MethodsRetNet genes underwent an assessment of genomic features and of CNV occurrence in the Database of Genomic Variants and literature. CNVs identified in an IRD cohort were characterized using targeted locus amplification (TLA) on extracted genomic DNA...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749240/epigenetic-dysregulation-of-the-erythropoietic-transcription-factor-klf1-and-the-beta-like-globin-locus-in-juvenile-myelomonocytic-leukemia
#3
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M Niemeyer, Christian Flotho
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions in leukemic cells. Since the regulation of globin gene transcription is known to be under epigenetic control, we set out to study the relation of DNA methylation patterns at β-/γ-globin promoters, mRNA and protein expression of globins, and epigenetic modifications of genes encoding the globin-regulatory transcription factors BCL11A and KLF1 in nucleated erythropoietic precursor cells of patients with JMML...
July 27, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28749103/decreased-mean-platelet-volume-is-associated-with-cervical-cancer-development
#4
Wen-Jie Shen, Shuang Fu, Na Li, Lu-Lu Li, Zhi-Gang Cao, Chuanfu Li, Tiemin Liu, Rui-Tao Wang
Background: Cervical cancer is the most common gynecological malignant disorder worldwide. Activated platelets play a key role in cancer development and progression. Mean platelet volume (MPV) is an early indicator of platelet activation. The aim of the present study was to evaluate MPV levels in patients with cervical cancer. Materials and methods: A total of 181 patients with cervical cancer and 181 controls between January 2015 and June 2015 were included in the study. Patient characteristics and hematologic test data at initial diagnosis were collected and odds ratios (ORs) and 95% confidence intervals (CIs) for risk of cervical cancer were calculated using multivariate logistic regression analyses across MPV quartiles...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749018/photoresponsive-conjugated-microporous-polymer-films-fabricated-by-electrochemical-deposition-for-controlled-release
#5
Ruiyang Zhao, Jishu Han, Mei Huang, Fusheng Liu, Lei Wang, Yuguang Ma
Stable controlled release system, conjugated microporous polymers (CMPs) with stimuli-responsive properties can be ideal structures because their 3D microporous matrix structure and possible stimulated response provide inherent switchable acceptor sites to capture and release guest molecules. Herein, the in situ electrochemical deposition of precursors (DTCzAzo) is utilized to construct highly crosslinked photoresponsive CMP films, which can reversibly undergo the trans-to-cis isomerization alternately with irradiation by 355 and 480 nm laser beams...
July 27, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28749006/highly-cis-1-4-selective-living-polymerization-of-unmasked-polar-2-2-methylidenebut-3-enyl-furan-and-diels-alder-addition
#6
Shiyu Long, Fei Lin, Changguang Yao, Dongmei Cui
The polymerization of a new polar diene-based monomer 2-(2-methylidenebut-3-enyl)furan (MBEF) without masking is achieved by using the bis(phosphino)carbazoleide-ligated yttrium (Y) alkyl complex upon the activation of [Ph3 C][B(C6 F5 )4 ]. Under mild conditions, the polymerizations under the monomer-to-Y ratios ranging from 100:1 to 500:1 perform fluently in high yields. The afforded polydienes bearing pendant terminal furan groups have high cis-1,4-regularity up to 98.6% and molecular weights close to the theoretic values and narrow polymer dispersity index(PDI) (1...
July 27, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28748981/terminal-vs-bridging-coordination-of-co-and-no-ligands-after-decarbonylation-of-w2cp2-%C3%AE-pr2-co-3-no-complexes-r-ph-cy-an-experimental-and-computational-study
#7
M Angeles Alvarez, M Esther García, Daniel García-Vivó, M Teresa Rueda, Miguel A Ruiz, Adrián Toyos, M Fernanda Vega
Compounds [M2Cp2(μ-PPh2)(CO)3(NO)] (M = Mo, W) were prepared by reacting the corresponding radicals [M2Cp2(μ-PPh2)(CO)4] with NO, and displayed a terminal, linear NO ligand arranged cis to the P-donor ligand (Mo-Mo = 3.1400(7) Å). The related PCy2-bridged complex [W2Cp2(μ-PCy2)(CO)3(NO)] was prepared in a one-pot, three step procedure first involving deprotonation of the hydride complex [W2Cp2(μ-H)(μ-PCy2)(CO)4] with K[BH(sec-Bu)3], then oxidation of the resulting salt K[W2Cp2(μ-PCy2)(CO)4] with [FeCp2]BF4 at 243 K, and eventually by reacting the so-formed radical [W2Cp2(μ-PCy2)(CO)4] with NO...
July 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28748851/insights-into-initial-demyelinating-episodes-of-central-nervous-system-during-puerperium
#8
Qian Wu, Bo Chen, Na Liu, Yang Hu, Chao Pan, Ping Zhang, Zhou-Ping Tang, Bi-Tao Bu
BACKGROUND: Inflammatory demyelinating disease of central nervous system (CNS) is an inflammatory disease characterized by a high childbearing female predominance. Labor-related alterations for postpartum demyelinating attacks are not entirely clear. This study aimed to summarize clinical features of female patients of reproductive age with initial CNS inflammatory demyelinating attacks during puerperium. METHODS: Fourteen female patients with initial demyelinating events during puerperium between January 2013 and December 2016 were retrospectively studied...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748573/a-novel-humanized-anti-tumor-necrosis-factor-related-apoptosis-inducing-ligand-r2-monoclonal-antibody-induces-apoptotic-and-autophagic-cell-death
#9
Longfei Chen, Yuhe Qiu, Zhenliang Hao, Jiong Cai, Shuyong Zhang, Yanxin Liu, Dexian Zheng
It is well known that the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/TNFSF10) is specifically expressed in various tumor cells, but less or no expression in most normal tissues and cells. While TRAIL engages with its native death receptors, TRAIL receptor 1 (TRAIL-R1) or 2 (TRAIL-R2), usually elicits the tumor cell death by apoptosis. In this study, we report that a novel humanized monoclonal antibody against TRAIL-R2 (named as zaptuzumab) well remain the biological activity of the parental mouse antibody AD5-10 inducing cell death in various cancer cells, but little effect on normal cells...
July 27, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28748555/digitalis-use-and-lung-cancer-risk-by-histological-type-in-men
#10
Wentao Li, Shao-Hua Xie, Lap-Ah Tse, Jesper Lagergren
Lung cancer risk and tumor characteristics differ between sexes. Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men. This was a nationwide Swedish population-based cohort study between July 1, 2005 and December 31, 2013. Data on the use of digitalis and organic nitrates in all male individuals were derived from the Swedish Prescribed Drug Registry. New lung cancer diagnoses among cohort participants were identified from the Swedish Cancer Registry...
July 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28748524/the-effects-of-segmentation-algorithms-on-the-measurement-of-18-f-fdg-pet-texture-parameters-in-non-small-cell-lung-cancer
#11
Usman Bashir, Gurdip Azad, Muhammad Musib Siddique, Saana Dhillon, Nikheel Patel, Paul Bassett, David Landau, Vicky Goh, Gary Cook
BACKGROUND: Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell lung cancer (NSCLC) for classification and prognostication. Several segmentation algorithms have been used to delineate tumours, but their effects on the reproducibility and predictive and prognostic capability of derived parameters have not been evaluated. The purpose of our study was to retrospectively compare various segmentation algorithms in terms of inter-observer reproducibility and prognostic capability of texture parameters derived from non-small cell lung cancer (NSCLC) (18)F-FDG PET/CT images...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28748424/association-of-adam-12-polymorphisms-with-the-risk-of-knee-osteoarthritis-meta-analysis-of-5048-cases-and-6848-controls
#12
Xuerong Hu, Guoli Sun, Weidong Wang
Several studies have suggested the association between ADAM 12 polymorphisms and the risk of osteoarthritis (OA), but the results remained controversial. Therefore, we designed a meta-analysis to systematically evaluate the association on this issue. A literature search for eligible studies was conducted in PubMed, Web of Science and Google Scholar databases. The association between ADAM 12 polymorphisms and knee OA risk was calculated by odds ratios (ORs) and 95% confidence intervals (CIs). Study heterogeneity, sensitivity and publication bias analyses were also conducted...
July 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28748324/alcohol-drinking-patterns-and-risk-of-diabetes-a-cohort-study-of-70-551-men-and-women-from-the-general-danish-population
#13
Charlotte Holst, Ulrik Becker, Marit E Jørgensen, Morten Grønbæk, Janne S Tolstrup
AIMS/HYPOTHESIS: Alcohol consumption is inversely associated with diabetes, but little is known about the role of drinking patterns. We examined the association between alcohol drinking patterns and diabetes risk in men and women from the general Danish population. METHODS: This cohort study was based on data from the Danish Health Examination Survey 2007-2008. Of the 76,484 survey participants, 28,704 men and 41,847 women were eligible for this study. Participants were followed for a median of 4...
July 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28748237/total-synthesis-of-kainic-acid-and-allo-kainic-acid-through-smi2-mediated-intramolecular-coupling-between-allyl-chloride-and-an-%C3%AE-%C3%AE-unsaturated-ester
#14
Junya Suzuki, Natsumi Miyano, Shunpei Yashiro, Taiki Umezawa, Fuyuhiko Matsuda
A 3,4-disubstituted pyrrolidine ring was effectively cyclized through SmI2-mediated reductive coupling between allyl chloride and an α,β-unsaturated ester, although little has been reported about SmI2-promoted C-C bond formation of an allyl chloride with an α,β-unsaturated ester. Selection of either the 3,4-cis- or 3,4-trans-selective cyclization can be accomplished simply by changing the additives from NiI2 to HMPA during reductive cyclization conducted in H2O-THF. Total synthesis of (-)-kainic acid and (+)-allo-kainic acid, which are pyrrolidine alkaloids used in neuroscience and neuropharmacology as useful molecular probes, was successfully achieved by using the stereo-complementary ring closure reactions promoted by SmI2 for the construction of the 2,3,4-trisubsituted pyrrolidine scaffold of kainoids...
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28747986/comparison-of-therapeutic-responses-to-an-anticancer-drug-in-three-stocks-of-icr-mice-derived-from-three-different-sources
#15
Ji Eun Sung, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Suk Jung, Kil Soo Kim, Dae Youn Hwang
Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipation inducers. To compare the inhibitory responses of ICR stocks obtained from three different sources to the anticancer drug cisplatin (Cis), alterations in tumor volume, histopathological structure, and toxicity were examined in Sarcoma 180 tumor-bearing Korl:ICR, A:ICR (USA source), and B:ICR (Japan source) mice treated with low and high concentrations of Cis (L-Cis and H-Cis, respectively)...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747578/pathologic-lymph-node-ratio-is-a-predictor-of-esophageal-carcinoma-patient-survival-a-literature-based-pooled-analysis
#16
Yuming Zhao, Shengyi Zhong, Zhenhua Li, Xiaofeng Zhu, Feima Wu, Yanxing Li
The positive lymph node ratio (LNR) has been suggested as a predictor of survival in patients with esophageal carcinoma (EC). However, existed evidences did not completely agree with each other. We sought to examine whether LNR was associated with overall survival (OS). Electronic database was searched for eligible literatures. The primary outcome was the relationship between LNR and OS, which was presented as hazard ratio (HR) with 95% confidence intervals (CIs). All statistical analyses were performed using STATA 11...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747570/prognostic-and-clinicopathological-significance-of-sirt1-expression-in-nsclc-a-meta-analysis
#17
Yifei Chen, Tao Wang, Wei Wang, Jiahao Hu, Ruiting Li, Shaojun He, Jiong Yang
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The prognosis of NSCLC is extremely poor and it is urgently to find a new marker. Numerous studies have confirmed that silent mating type information regulation 2 homolog-1 (sirtuin1; SIRT1) is abnormally expressed in NSCLC. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of SIRT1 in NSCLC. A total of seven eligible studies, including 6 on clinicopathological features, 7 on prognosis were identified from the databases...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747542/meta-analysis-showing-that-ercc1-polymorphism-is-predictive-of-osteosarcoma-prognosis
#18
REVIEW
Xueyong Liu, Zhan Zhang, Chunbo Deng, Yihao Tian, Xun Ma
To investigate correlations between excision repair cross-complementation group 1 (ERCC1) and 2 (ERCC2) polymorphisms and osteosarcoma prognosis, we conducted a meta-analysis of studies published through October 2016. Studies were identified in the PubMed, ScienceDirect, Springer, and Web of Science databases using preferred reporting items for systematic reviews and meta-analyses (PRISMA). Odds ratios (ORs) or hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS), tumor response (TR), and event-free survival (EFS) were estimated...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747224/regions-of-common-inter-individual-dna-methylation-differences-in-human-monocytes-genetic-basis-and-potential-function
#19
Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann, Bernhard Horsthemke
BACKGROUND: There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. RESULTS: We identified 157 differentially methylated regions (DMRs) with four or more CpGs, almost none of which has been described before...
July 26, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28746836/a-human-induced-pluripotent-stem-cell-based-in-vitro-assay-predicts-developmental-toxicity-through-a-retinoic-acid-receptor-mediated-pathway-for-a-series-of-related-retinoid-analogues
#20
Jessica A Palmer, Alan M Smith, Laura A Egnash, Michael R Colwell, Elizabeth L R Donley, Fred R Kirchner, Robert E Burrier
The relative developmental toxicity potency of a series of retinoid analogues was evaluated using a human induced pluripotent stem (iPS) cell assay that measures changes in the biomarkers ornithine and cystine. Analogue potency was predicted, based on the assay endpoint of the ornithine/cystine (o/c) ratio, to be all-trans-retinoic acid>TTNPB>13-cis-retinoic acid≈9-cis-retinoic acid>acitretin>etretinate>retinol. These rankings correlate with in vivo data and demonstrate successful application of the assay to rank a series of related toxic and non-toxic compounds...
July 23, 2017: Reproductive Toxicology
keyword
keyword
33224
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"