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CXCR7

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https://www.readbyqxmd.com/read/28322746/truncation-of-cxcl12-by-cd26-reduces-its-cxc-chemokine-receptor-4-and-atypical-chemokine-receptor-3-dependent-activity-on-endothelial-cells-and-lymphocytes
#1
Rik Janssens, Anneleen Mortier, Daiane Boff, Pieter Ruytinx, Mieke Gouwy, Bo Vantilt, Olav Larsen, Viktorija Daugvilaite, Mette M Rosenkilde, Marc Parmentier, Sam Noppen, Sandra Liekens, Jo Van Damme, Sofie Struyf, Mauro M Teixeira, Flávio A Amaral, Paul Proost
The chemokine CXCL12 or stromal cell-derived factor 1/SDF-1 attracts hematopoietic progenitor cells and mature leukocytes through the G protein-coupled CXC chemokine receptor 4 (CXCR4). In addition, it interacts with atypical chemokine receptor 3 (ACKR3 or CXCR7) and glycosaminoglycans. CXCL12 activity is regulated through posttranslational cleavage by CD26/dipeptidyl peptidase 4 that removes two N-terminal amino acids. CD26-truncated CXCL12 does not induce calcium signaling or chemotaxis of mononuclear cells...
March 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28295006/-impact-of-preoperative-drug-therapy-on-the-expression-of-angiogenesis-markers-in-colorectal-liver-metastases
#2
A V Varlamov, E M Pal'tseva, M I Sekacheva, O G Skipenko, D N Fedorov
AIM: to study changes in the expression of angio- and vasculogenesis markers in colorectal adenocarcinoma metastases to the liver during combined cytotoxic and targeted anti-VEGF therapy versus cytotoxic monotherapy. SUBJECTS AND METHODS: Intraoperative samples from 96 patients with colorectal adenocarcinomas metastases to the liver were immunohistochemically examined. The investigation enrolled patients who had preoperatively received either combined FOLFOX6 cytotoxic therapy and targeted anti-VEGF therapy with bevacizumab or only FOLFOX6 therapy, as well as patients who had not received preoperative anti-tumor drug treatment...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28287613/knockdown-of-long-non-coding-rna-xist-increases-blood-tumor-barrier-permeability-and-inhibits-glioma-angiogenesis-by-targeting-mir-137
#3
H Yu, Y Xue, P Wang, X Liu, J Ma, J Zheng, Z Li, Z Li, H Cai, Y Liu
Antiangiogenic therapy plays a significant role in combined glioma treatment. However, poor permeability of the blood-tumor barrier (BTB) limits the transport of chemotherapeutic agents, including antiangiogenic drugs, into tumor tissues. Long non-coding RNAs (lncRNAs) have been implicated in various diseases, especially malignant tumors. The present study found that lncRNA X-inactive-specific transcript (XIST) was upregulated in endothelial cells that were obtained in a BTB model in vitro. XIST knockdown increased BTB permeability and inhibited glioma angiogenesis...
March 13, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28283801/serum-amyloid-a1-is-upregulated-in-human-glioblastoma
#4
Franciele Hinterholz Knebel, Miyuki Uno, Thais F Galatro, Luziane Potrich Bellé, Sueli Mieko Oba-Shinjo, Suely Kazue N Marie, Ana Campa
Serum amyloid A1 (SAA1) is a sensitive acute phase reactant primarily produced by the liver in response to acute inflammation. We have recently shown that SAA affects proliferation, migration, and invasion of glioblastoma cell lines, which suggest its participation in the malignant process. Consistently, levels of SAA have been used as a non-invasive biomarker for the prognosis of many cancers. In this study, we aimed to investigate SAA serum levels and expression of SAA genes in human astrocytomas tissues...
March 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28281844/cxcr7-as-a-chemokine-receptor-for-sdf-1-promotes-gastric-cancer-progression-via-mapk-pathways
#5
Ameng Shi, Haitao Shi, Lei Dong, Shaoxian Xu, Miao Jia, Xiaoyan Guo, Ting Wang
OBJECTIVE: As the alternate receptor for stromal cell-derived factor-1 (SDF-1) except CXCR4, CXCR7 has been shown to be involved in the progression of some malignancies. However, the role of SDF-1/CXCR7 in gastric cancer (GC) remains unclear. MATERIALS AND METHODS: CXCR7 expression was examined in 83 human GC tissues and adjacent non-cancer tissues (ANCTs) by immunohistochemistry, in three human GC cell lines (MGC-803, BGC-823 and SGC-7901) by reverse transcription-PCR and western blot...
March 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28255115/-expression-of-chemokine-cxcl12-and-its-receptor-cxcr4-and-cxcr7-in-different-molecular-subtypes-of-human-breast-carcinoma-and-the-clinical-significance
#6
Wei Wu, Liyuan Qian, Jing Dai, Boni Ding, Xuedong Chen
OBJECTIVE: To study the expressions and the clinical significance of chemokine CXCL12 and its receptor CXCR4, CXCR7 in the human breast carcinoma (BC) with different molecular subtypes.
 Methods: The mRNA expressions of CXCL12, CXCR4 and CXCR7 in tissues from 80 patients with different molecular subtype of BC were measured by qRT-PCR. The protein expressions of CXCL12, CXCR4 and CXCR7 in paraffin-embedded samples from 160 patients with different molecular subtypes were detected by immunohistochemical staining...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28253363/mutation-in-cpsf6-cfim68-cleavage-and-polyadenylation-specificity-factor-subunit-6-causes-short-3-utrs-and-disturbs-gene-expression-in-developing-embryos-as-revealed-by-an-analysis-of-primordial-germ-cell-migration-using-the-medaka-mutant-naruto
#7
Takao Sasado, Hisato Kondoh, Makoto Furutani-Seiki, Kiyoshi Naruse
Our previous studies analyzing medaka mutants defective in primordial germ cell (PGC) migration identified cxcr4b and cxcr7, which are both receptors of the chemokine sdf1/cxcl12, as key regulators of PGC migration. Among PGC migration mutants, naruto (nar) is unique in that the mutant phenotype includes gross morphological abnormalities of embryos, suggesting that the mutation affects a broader range of processes. A fine genetic linkage mapping and genome sequencing showed the nar gene encodes Cleavage and Polyadenylation Specificity Factor subunit 6 (CPSF6/CFIm68)...
2017: PloS One
https://www.readbyqxmd.com/read/28239742/the-role-of-the-sdf-1-cxcr7-axis-on-the-growth-and-invasion-ability-of-endometrial-cancer-cells
#8
Hong-Qin Gu, Zhen-Bo Zhang, Jia-Wen Zhang, Qian-Qian Wang, Xiao-Wei Xi, Yin-Yan He
PURPOSE: Stroma-derived factor-1 (SDF-1) and its receptor C-X-C chemokine receptor-4 (CXCR4) are involved in human endometrial carcinoma (EC) progression. CXCR7 is another important receptor of SDF-1 and has a higher affinity with SDF-1 compared with that of CXCR4. This paper aims to study the effects of the SDF-1/CXCR7 axis on the growth and invasion ability of EC cells. METHODS: CXCR7 expression was evaluated by quantitative RT-PCR, immunohistochemistry, immunocytochemistry and Western blotting in EC cell lines and 30 cases of primary EC tissue from patients...
February 27, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28188248/the-pivotal-role-of-cxcr7-in-stabilization-of-the-pulmonary-epithelial-barrier-in-acute-pulmonary-inflammation
#9
Kristian-Christos Ngamsri, Anika Müller, Hans Bösmüller, Jutta Gamper-Tsigaras, Jörg Reutershan, Franziska M Konrad
Acute pulmonary inflammation is still a frightening complication in intensive care units and has a high mortality. Specific treatment is not available, and many details of the pathomechanism remain unclear. The recently discovered chemokine receptor CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to be involved in inflammation. We chose to investigate the detailed role of CXCR7 in a murine model of LPS inhalation. Inflammation increased pulmonary expression of CXCR7, and the receptor was predominantly expressed on pulmonary epithelium and on polymorphonuclear neutrophil (PMNs) after transepithelial migration into the alveolar space...
February 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28177527/effects-of-linagliptin-on-human-immortalized-podocytes-a-cellular-system-to-study-dipeptidyl-peptidase-4-inhibition
#10
Gianluca Miglio, Giovanna Vitarelli, Thomas Klein, Elisa Benetti
BACKGROUND AND PURPOSE: Dipeptidyl-peptidase 4 (DPP4) is expressed by resident renal cells, including glomerular cells. DPP4 inhibitors (gliptins) exert albuminuria lowering effects, but the role of renal DPP4 as a pharmacological target has not been elucidated. To better understand the actions of gliptins, the effects of linagliptin on the behaviour of immortalized human podocytes and mesangial cells were evaluated. EXPERIMENTAL APPROACH: The expression of DPP4 was measured at both the mRNA and protein levels...
February 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28154007/loss-of-endothelial-cxcr7-impairs-vascular-homeostasis-and-cardiac-remodeling-after-myocardial-infarction-implications-for-cardiovascular-drug-discovery
#11
Huifeng Hao, Sheng Hu, Hong Chen, Dawei Bu, Liyuan Zhu, Chuansheng Xu, Fei Chu, Xingyu Huo, Yue Tang, Xiaogang Sun, Bisen Ding, Depei Liu, Shengshou Hu, Miao Wang
BACKGROUND: -Genome-wide association studies identified the association of the CXCL12 genetic locus (which encodes the chemokine CXCL12, also known as stromal cell-derived factor 1) with coronary artery disease (CAD) and myocardial infarction (MI). Unlike CXCR4, the classical receptor for CXCL12, the function of CXCR7 (the most recently identified receptor) in vascular responses to injury and in MI remains unclear. METHODS: -Tissue expression of CXCR7 was examined in arteries from mice and humans...
February 2, 2017: Circulation
https://www.readbyqxmd.com/read/28137917/elevating-cxcr7-improves-angiogenic-function-of-epcs-via-akt-gsk-3%C3%AE-fyn-mediated-nrf2-activation-in-diabetic-limb-ischemia
#12
Xiaozhen Dai, Xiaoqing Yan, Jun Zeng, Jing Chen, Yuehui Wang, Jun Chen, Yan Li, Michelle T Barati, Kupper A Wintergerst, Kejian Pan, Matthew A Nystoriak, Daniel J Conklin, Gregg Rokosh, Paul N Epstein, Xiaokun Li, Yi Tan
RATIONALE: Endothelial progenitor cells (EPCs) respond to stromal cell-derived factor 1 (SDF-1) through chemokine receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in diabetes mellitus-induced EPCs dysfunction remains unknown. OBJECTIVE: To determine the role of SDF-1 receptors in diabetic EPCs dysfunction. METHODS AND RESULTS: CXCR7 expression, but not CXCR4 was reduced in EPCs from db/db mice, which coincided with impaired tube formation...
March 3, 2017: Circulation Research
https://www.readbyqxmd.com/read/28115158/mdia2-and-cxcl12-cxcr4-chemokine-signaling-intersect-to-drive-tumor-cell-amoeboid-morphological-transitions
#13
Meghan M Wyse, Silvia Goicoechea, Rafael Garcia-Mata, Andrea L Nestor-Kalinoski, Kathryn M Eisenmann
Morphological plasticity in response to environmental cues in migrating cancer cells requires F-actin cytoskeletal rearrangements. Conserved formin family proteins play critical roles in cell shape, tumor cell motility, invasion and metastasis, in part, through assembly of non-branched actin filaments. Diaphanous-related formin-2 (mDia2/Diaph3/Drf3/Dia) regulates mesenchymal-to-amoeboid morphological conversions and non-apoptotic blebbing in tumor cells by interacting with its inhibitor diaphanous-interacting protein (DIP), and disrupting cortical F-actin assembly and bundling...
March 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28072604/epigenetic-upregulation-of-cxcl12-expression-mediates-antitubulin-chemotherapeutics-induced-neuropathic-pain
#14
Ting Xu, Xiao-Long Zhang, Han-Dong Ou-Yang, Zhen-Yu Li, Cui-Cui Liu, Zhen-Zhen Huang, Jing Xu, Jia-You Wei, Bi-Lin Nie, Chao Ma, Shao-Ling Wu, Wen-Jun Xin
Clinically, Microtubule-targeted agents-induced neuropathic pain hampers chemotherapeutics for patients with cancer. Here, we found that application of paclitaxel or vincristine increased the protein and mRNA expression of CXCL12 and frequency and amplitude of miniature excitatory post synaptic currents (mEPSCs) in spinal dorsal horn neurons. Spinal local application of CXCL12 induced the long-term potentiation of nociceptive synaptic transmission and increased the amplitude of mEPSCs. Inhibition of CXCL12 using the transgenic mice (CXCL12) or neutralizing antibody or siRNA ameliorated the mEPSC's enhancement and mechanical allodynia...
April 2017: Pain
https://www.readbyqxmd.com/read/28040478/cathepsin-k-cleavage-of-sdf-1%C3%AE-inhibits-its-chemotactic-activity-towards-glioblastoma-stem-like-cells
#15
Vashendriya V V Hira, Urška Verbovšek, Barbara Breznik, Matic Srdič, Marko Novinec, Hala Kakar, Jill Wormer, Britt Van der Swaan, Brigita Lenarčič, Luiz Juliano, Shwetal Mehta, Cornelis J F Van Noorden, Tamara T Lah
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor patient survival that is at least partly caused by malignant and therapy-resistant glioma stem-like cells (GSLCs) that are protected in GSLC niches. Previously, we have shown that the chemo-attractant stromal-derived factor-1α (SDF-1α), its C-X-C receptor type 4 (CXCR4) and the cysteine protease cathepsin K (CatK) are localized in GSLC niches in glioblastoma. Here, we investigated whether SDF-1α is a niche factor that through its interactions with CXCR4 and/or its second receptor CXCR7 on GSLCs facilitates their homing to niches...
December 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27996149/fatal-attractions-correlations-of-cxcl12-cxcr4-cxcr7-expression-with-disease-progression-in-melanoma-and-kaposi-sarcoma
#16
L C Spender, G J Inman
No abstract text is available yet for this article.
December 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27986950/early-pancreatic-cancer-lesions-suppress-pain-through-cxcl12-mediated-chemoattraction-of-schwann-cells
#17
Ihsan Ekin Demir, Kristina Kujundzic, Paulo L Pfitzinger, Ömer Cemil Saricaoglu, Steffen Teller, Timo Kehl, Carmen Mota Reyes, Linda S Ertl, Zhenhua Miao, Thomas J Schall, Elke Tieftrunk, Bernhard Haller, Kalliope Nina Diakopoulos, Magdalena U Kurkowski, Marina Lesina, Achim Krüger, Hana Algül, Helmut Friess, Güralp O Ceyhan
Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However, we hypothesized the opposite process, that precancerous pancreatic cells secrete chemokines that chemoattract Schwann cells (SC) of nerves and thus induce ready-to-use routes of dissemination in early carcinogenesis. Here we show a peculiar role for the chemokine CXCL12 secreted in early PDAC and for its receptors CXCR4/CXCR7 on SC in the initiation of neural invasion in the cancer precursor stage and the resulting delay in the onset of PDAC-associated pain...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27941339/overexpression-of-cxcr7-is-a-novel-prognostic-indicator-in-gastric-cancer
#18
Sho Nambara, Tomohiro Iguchi, Eiji Oki, Patrick Tan, Yoshihiko Maehara, Koshi Mimori
BACKGROUND: Among several candidate genes that promote peritoneal dissemination extracted by comprehensive expression analysis of both in vivo selected metastatic cell lines and patients with gastric cancer, we focused on the chemokine (C-X-C motif) receptor (CXCR7) and explored its clinicopathological significance in gastric cancer. METHODS: CXCR7 expression was evaluated by microarray data in the Singapore cohort (n = 196) and by immunohistochemistry and reverse transcription quantitative real-time polymerase chain reaction in the Japanese cohort (n = 195)...
December 10, 2016: Digestive Surgery
https://www.readbyqxmd.com/read/27904690/mirna-101-acts-as-a-tumor-suppressor-in-oral-squamous-cell-carcinoma-by-targeting-cx-chemokine-receptor-7
#19
Yuan Hui, Yu Li, Yan Jing, Jian-Q Feng, Yin Ding
miR-101 is significantly downregulated in various human cancers, including oral squamous cell carcinoma (OSCC). However, the role of miR-101 in OSCC has not been elucidated. In this study, miR-101 lowly expressed in OSCC tissues and cell lines compared with that in adjacent normal tissues and human normal oral keratinocyte cells. Bioinformatics analysis predicted that miR-101 could potentially target CX chemokine receptor 7 (CXCR7), a promoter of tumor development, to attenuate OSCC progression. Restoring miR-101 expression in OSCC cells suppressed cell proliferation, invasion, and migration...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27875312/mutational-analysis-of-atypical-chemokine-receptor-3-ackr3-cxcr7-interaction-with-its-chemokine-ligands-cxcl11-and-cxcl12
#20
Besma Benredjem, Mélanie Girard, David Rhainds, Geneviève St-Onge, Nikolaus Heveker
Atypical chemokine receptors do not mediate chemotaxis or G protein signaling, but they recruit arrestin. They also efficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance and termination. ACKR3, also known as CXCR7, binds and degrades the constitutive chemokine CXCL12, which also binds the canonical receptor CXCR4, and CXCL11, which also binds CXCR3. Here we report comprehensive mutational analysis of the ACKR3 interaction with its chemokine ligands, using 30 substitution mutants...
January 6, 2017: Journal of Biological Chemistry
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