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https://www.readbyqxmd.com/read/29422961/microrna-100-suppresses-human-gastric-cancer-cell-proliferation-by-targeting-cxcr7
#1
Yongfeng Cao, Jiaye Song, Jianjuan Ge, Zhuchen Song, Jia Chen, Changping Wu
microRNAs (miRs) are a class of small non-coding RNAs that have been demonstrated to have a crucial role in tumorigenesis of human cancers, including gastric cancer (GC). Previous results have established that miR-100 participated in the development of GC; however, the underlying mechanism remains largely unknown. The preesent study utilized reverse transcription-quantitative polymerase chain reaction to analyze the expression of miR-100 in GC tissues and adjacent normal tissues. The present results indicated that the expression of miR-100 was downregulated in GC tissues when compared to the adjacent normal tissues...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29420253/the-c-x-c-signalling-system-in-the-rodent-vs-primate-testis-impact-on-germ-cell-niche-interaction
#2
Laura Heckmann, Tim Pock, Ina Tröndle, Nina Neuhaus
In zebrafish, action of the chemokine Cxcl12 is mediated through its G-protein coupled seven-transmembrane domain receptor Cxcr4 and the atypical receptor Cxcr7. Employing this animal model it was revealed that this Cxcl12 signalling system plays a crucial role for directed migration of primordial germ cells (PGC) during early testicular development. Importantly, subsequent studies indicated that this regulatory mechanism is evolutionarily conserved also in mice. What is more, the functional role of the CXCL12 system does not seem to be limited to early phases of testicular development...
February 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29408206/the-5t4-oncofetal-glycoprotein-does-not-act-as-a-general-organizer-of-the-cxcl12-system-in-cancer-cells
#3
Malte Puchert, Christian Koch, Jürgen Engele
The chemokine, CXCL12, promotes cancer growth and metastasis through interaction with either CXCR4 and/or CXCR7. This tumor-specific organization of the CXCL12 system obscures current therapeutic approaches, aiming at the selective inactivation of CXCL12 receptors. Since it has been previously suggested that the cellular use of CXCR4 or CXCR7 is dictated by the 5T4 oncofetal glycoprotein, we have now tested whether 5T4 would represent a general and reliable marker for the organization of the CXCL12 system in cancer cells...
February 2, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29393458/microrna-126-stromal-cell-derived-factor-1-c-x-c-chemokine-receptor-type-7-signaling-pathway-promotes-post-stroke-angiogenesis-of-endothelial-progenitor-cell-transplantation
#4
Caiyun Shan, Yongsheng Ma
Stroke is the most common cause of mortality worldwide. Post-stroke angiogenesis is of great significance to the treatment of strokes. The aim of the present study was to investigate the mechanism underlying the angiogenesis-promoting effect of microRNA‑126 (miR‑126)‑associated signaling pathways using a stroke model in vivo and a cell migration model in vitro. Bone marrow‑derived endothelial progenitor cells (EPCs) were extracted and identified using a density gradient method. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to examine the expression levels of miR‑126 and C‑X‑C chemokine receptor type 7 (CXCR7)...
January 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29390073/lyg-202-inhibits-activation-of-endothelial-cells-and-angiogenesis-through-cxcl12-cxcr7-pathway-in-breast-cancer
#5
Kai Zhao, Yuyuan Yao, Xuwei Luo, Binyan Lin, Yujie Huang, Yuxin Zhou, Zhiyu Li, Qinglong Guo, Na Lu
Angiogenesis is critical for the growth and metastasis of triple-negative breast cancer (TNBC) and its inhibition reduces the risk of progression of metastatic TNBC. In this study, we investigated that LYG-202, a flavonoid with a piperazine substitution, inhibited angiogenesis induced by conditioned media (CM) from MDA-MB-231 cells under hypoxia and revealed its underlying mechanism. The results showed that LYG-202 decreased CXCL12 secretion and CXCR7 expression, leading to suppression of its downstream ERK/AKT/NF-κB signaling, which eventually decreased the expression of MMP-2, MMP-9, RhoA and increased VE-cadherin expression in EA...
January 30, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29317710/chemokine-receptor-7-overexpression-promotes-mesenchymal-stem-cell-migration-and-proliferation-via-secreting-chemokine-ligand-12
#6
Ling Liu, Jian-Xiao Chen, Xi-Wen Zhang, Qin Sun, Lan Yang, Airan Liu, Shuling Hu, Fengmei Guo, Songqiao Liu, Yingzi Huang, Yi Yang, Hai-Bo Qiu
Great interest has been shown in mesenchymal stem cell (MSC) therapy in a wide variety of clinical domains. However, the therapeutic efficiency depends on the proliferation and migration of MSCs. Chemokine receptors are involved in regulating the proliferation and migration to the specific organs of MSCs in different microenvironments. CXC receptor seven (CXCR7), a newly discovered Chemokine ligand 12 (CXCL12) receptor, has organ specificity for tumour migration. We hypothesized that CXCR7 expression affects proliferation and migration of MSCs...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29304539/expression-and-cellular-localization-of-cxcr4-and-cxcl12-in-human-carotid-atherosclerotic-plaques
#7
Sophie Merckelbach, Emiel P C van der Vorst, Michael Kallmayer, Christoph Rischpler, Rainer Burgkart, Yvonne Döring, Gert-Jan de Borst, Markus Schwaiger, Hans-Henning Eckstein, Christian Weber, Jaroslav Pelisek
BACKGROUND AND AIMS:  The CXCR4/CXCL12 complex has already been associated with progression of atherosclerosis; however, its exact role is yet unknown. The aim of this study was to analyse the expression and cellular localization of CXCL12 and its receptor CXCR4 in human carotid atherosclerotic plaques. METHODS:  Carotid plaques (n = 58; 31 stable, 27 unstable, based on histological characterization of plaque morphology) were obtained during carotid endarterectomy, and 10 healthy vessels were used as a control...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29283028/cxcl12-cxcr4-cxcr7-chemokine-axis-in-the-central-nervous-system-therapeutic-targets-for-remyelination-in-demyelinating-diseases
#8
Tianci Chu, Lisa B E Shields, Yi Ping Zhang, Shi-Qing Feng, Christopher B Shields, Jun Cai
The chemokine CXCL12 plays a vital role in regulating the development of the central nervous system (CNS) by binding to its receptors CXCR4 and CXCR7. Recent studies reported that the CXCL12/CXCR4/CXCR7 axis regulates both embryonic and adult oligodendrocyte precursor cells (OPCs) in their proliferation, migration, and differentiation. The changes in the expression and distribution of CXCL12 and its receptors are tightly associated with the pathological process of demyelination in multiple sclerosis (MS), suggesting that modulating the CXCL12/CXCR4/CXCR7 axis may benefit myelin repair by enhancing OPC recruitment and differentiation...
December 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29277895/enzalutamide-and-cxcr7-inhibitor-combination-treatment-suppresses-cell-growth-and-angiogenic-signaling-in-castration-resistant-prostate-cancer-models
#9
Yong Luo, Abul Kalam Azad, Styliani Karanika, Spyridon P Basourakos, Xuemei Zuo, Jianxiang Wang, Luan Yang, Guang Yang, Dimitrios Korentzelos, Jianhua Yin, Sanghee Park, Penglie Zhang, James J Campbell, Thomas J Schall, Guangwen Cao, Likun Li, Timothy C Thompson
Previous studies have shown that increased levels of chemokine receptor CXCR7 are associated with the increased invasiveness of prostate cancer cells. We now show that CXCR7 expression is upregulated in VCaP and C4-2B cells after enzalutamide (ENZ) treatment. ENZ treatment induced apoptosis (sub-G1) in VCaP and C4-2B cells, and this effect was further increased after combination treatment with ENZ and CCX771, a specific CXCR7 inhibitor. The levels of p-EGFR (Y1068), p-AKT (T308) and VEGFR2 were reduced after ENZ and CCX771 combination treatment compared to single agent treatment...
December 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29275565/-expression-of-integrin-%C3%AE-v%C3%AE-3-cxc-chemokine-receptor-4-and-cxc-chemokine-receptor-7-and-their-relationship-with-lymph-node-metastasis-in-squamous-cell-carcinoma-of-head-and-neck
#10
P Li, W L Li, J X Qi
Objective: To investigate the expression of integrin αvβ3, CXC chemokine receptor (CXCR)4 and CXCR7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck (SCCHN). Methods: The expression of integrin αvβ3, CXCR4 and CXCR7 was detected by immunohistochemistry SABC in 92 cases of primary SCCHN, metastatic lymph node, normal oral mucosa tissues and normal lymph nodes. Results: The positive rate of the expression of integrin αvβ3, CXCR4 and CXCR7 was 75% (69/92), 81%(75/92) and 76%(70/92), respectively in primary SCCHN, and was 82%(75/92), 76%(70/92) and 65%(60/92), respectively in metastatic lymph node...
December 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29250768/critical-involvement-of-atypical-chemokine-receptor-cxcr7-in-allergic-airway-inflammation
#11
Hung-Chih Chang, Po-Han Huang, Fu-Sheng Syu, Chia-Hung Hsieh, Sunny Li-Yun Chang, Jean Lu, Hui-Chen Chen
Trafficking and recruitment of immune cells to the site of inflammation with spatial and temporal synchronization is crucial for the development of allergic airway inflammation. Particularly, chemokines are known to be key players in these processes. Previous studies revealed that the CXCL12/CXCR4 axis plays an important role in regulating allergic airway inflammation. However, the role of CXCR7, a recently discovered second receptor for CXCL12, in regulating airway inflammation has not been explored. Initially, CXCR7 was considered as a decoy receptor; however, numerous subsequent studies revealed that engagement of CXCR7 triggered its own signaling or modulated CXCR4-mediated signaling...
December 18, 2017: Immunology
https://www.readbyqxmd.com/read/29218250/evaluation-of-the-role-of-downregulation-of-snf5-ini1-core-subunit-of-swi-snf-complex-in-clear-cell-renal-cell-carcinoma-development
#12
Elzbieta Sarnowska, Michal Szymanski, Nataliia Rusetska, Marcin Ligaj, Iga Jancewicz, Pawel Cwiek, Marta Skrodzka, Marcin Leszczynski, Joanna Szarkowska, Alicja Chrzan, Malgorzata Stachowiak, Jaroslaw Steciuk, Anna Maassen, Lech Galek, Tomasz Demkow, Janusz A Siedlecki, Tomasz J Sarnowski
Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found suggesting potential impairment of this complex function in ccRCC. In this study we assessed the extent to which the core SWI/SNF complex subunit - INI1 (hSNF5/SMARCB1) is affected in ccRCC and whether it has any consequences on the development of this type of cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29201496/platelets-prime-hematopoietic-and-vascular-niche-to-drive-angiocrine-mediated-liver-regeneration
#13
Koji Shido, Deebly Chavez, Zhongwei Cao, Jane Ko, Shahin Rafii, Bi-Sen Ding
In mammals, the livers regenerate after chemical injury or resection of hepatic lobe by hepatectomy. How liver regeneration is initiated after mass loss remains to be defined. Here, we report that following liver injury, activated platelets deploy SDF-1 and VEGF-A to stimulate CXCR7+ liver sinusoidal endothelial cell (LSEC) and VEGFR1+ myeloid cell, orchestrating hepatic regeneration. After carbon tetrachloride (CCl4) injection or hepatectomy, platelets and CD11b+VEGFR1+ myeloid cells were recruited LSEC, and liver regeneration in both models was impaired in thrombopoietin-deficient (Thpo-/-) mice lacking circulating platelets...
2017: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29175422/targeting-cxcr7-improves-the-efficacy-of-breast-cancer-patients-with-tamoxifen-therapy
#14
REVIEW
Mingang Hao, Xiaoling Weng, Yingying Wang, Xueqin Sun, Tingting Yan, Yu Li, Lidan Hou, Xiangjun Meng, Jianhua Wang
Chemokine (C-X-C motif) receptor 7 (CXCR7) has been established to be involved in breast cancer (BCa) progression. However, the role of CXCR7 in different subtype of BCa still remains unclear. Here we note that CXCR7 expression is significantly amplified in Luminal type BCa tissues as compared with Her2 and TNBC types through data-mining in TCGA datasets, and its protein level positively correlates with ERα expression by staining of human BCa tissue. Interestingly, alteration of CXCR7 expression in Luminal type BCa cells is able to modulate the expression of ERαthrough ubiquitinationat post-translational level...
November 23, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29163165/the-modulatory-properties-of-chronic-antidepressant-drugs-treatment-on-the-brain-chemokine-chemokine-receptor-network-a-molecular-study-in-an-animal-model-of-depression
#15
Ewa Trojan, Joanna Ślusarczyk, Katarzyna Chamera, Katarzyna Kotarska, Katarzyna Głombik, Marta Kubera, Agnieszka Basta-Kaim
An increasing number of studies indicate that the chemokine system may be the third major communication system of the brain. Therefore, the role of the chemokine system in the development of brain disorders, including depression, has been recently proposed. However, little is known about the impact of the administration of various antidepressant drugs on the brain chemokine - chemokine receptor axis. In the present study, we used an animal model of depression based on the prenatal stress procedure. We determined whether chronic treatment with tianeptine, venlafaxine, or fluoxetine influenced the evoked by prenatal stress procedure changes in the mRNA and protein levels of the homeostatic chemokines, CXCL12 (SDF-1α), CX3CL1 (fractalkine) and their receptors, in the hippocampus and frontal cortex...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29156740/improvement-of-therapeutic-effects-of-mesenchymal-stem-cells-in-myocardial-infarction-through-genetic-suppression-of-microrna-142
#16
Liu-Xue Yang, Chun-Ling Wei, Man-Li Guo, Yong Zhang, Feng Bai, Shao-Gang Ma
Transplanted mesenchymal stem cells (MSCs) have been shown to contribute to myocardial repair after myocardial infarction (MI), primarily through production and secretion some growth factors and cytokines related to cell survival and regeneration. Further improvement of the therapeutic potential of MSCs appears to be an attractive strategy for MI treatment. CXC chemokine receptor (CXCR) 7 is the receptor for stromal cell-derived factor-1 (SDF-1), an important chemokine that is essential for tissue repair and angiogenesis...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152123/msc-derived-cytokines-repair-radiation-induced-intra-villi-microvascular-injury
#17
Peng-Yu Chang, Bo-Yin Zhang, Shuang Cui, Chao Qu, Li-Hong Shao, Tian-Kai Xu, Ya-Qin Qu, Li-Hua Dong, Jin Wang
Microvascular injury initiates the pathogenesis of radiation enteropathy. As previously demonstrated, the secretome from mesenchymal stem cells contains various angiogenic cytokines that exhibited therapeutic potential for ischemic lesions. As such, the present study aimed to investigate whether cytokines derived from mesenchymal stem cells can repair endothelial injuries from irradiated intestine. Here, serum-free medium was conditioned by human adipose-derived mesenchymal stem cells, and we found that there were several angiogenic cytokines in the medium, including IL-8, angiogenin, HGF and VEGF...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146732/mir-539-5p-inhibits-experimental-choroidal-neovascularization-by-targeting-cxcr7
#18
Yifan Feng, Jing Wang, Yuanzhi Yuan, Xi Zhang, Minqian Shen, Fei Yuan
Stromal cell-derived factor-1 (SDF-1) has been previously confirmed to participate in the formation of choroidal neovascularization (CNV) via its receptor, CXC chemokine receptor (CXCR) 4; CXCR7 is a recently identified receptor for SDF-1. The molecular mechanisms and therapeutic value of CXCR7 in CNV remain undefined. In this study, experimental CNV was induced by laser photocoagulation in Brown-Norway pigmented rats, and aberrant CXCR7 overexpression was detected in the retinal pigment epithelial/choroid/sclera tissues of laser-injured eyes...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29125295/structure-activity-relationships-and-biological-characterization-of-a-novel-potent-and-serum-stable-c-x-c-chemokine-receptor-type-4-cxcr4-antagonist
#19
Salvatore Di Maro, Francesco Saverio Di Leva, Anna Maria Trotta, Diego Brancaccio, Luigi Portella, Michela Aurilio, Stefano Tomassi, Anna Messere, Deborah Sementa, Secondo Lastoria, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli
In our ongoing pursuit of CXCR4 antagonists as potential anticancer agents, we recently developed a potent, selective and plasma stable peptide, Ac-Arg-Ala-[D-Cys-Arg-Phe-Phe-Cys]-COOH (3). Nevertheless, this compound was still not enough potent (IC50 ≈ 53 nM) to enter preclinical studies. Thus, a lead-optimization campaign was here undertaken to further improve the binding affinity of 3 while preserving its selectivity and proteolytic stability. Specifically, extensive structure-activity relationships (SARs) investigations were carried out on both its aromatic and disulfide forming amino acids...
November 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29123467/the-role-of-sdf-1-cxcr4-cxcr7-in-neuronal-regeneration-after-cerebral-ischemia
#20
REVIEW
Xi Cheng, Huibin Wang, Xiuchun Zhang, Shanshan Zhao, Zhike Zhou, Xiaopeng Mu, Chuansheng Zhao, Weiyu Teng
Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer. SDF-1 activates two G protein-coupled receptors, CXCR4 and CXCR7; these are expressed in both developing and mature CNSs and participate in multiple physiological and pathological events, e.g., inflammatory response, neurogenesis, angiogenesis, hematopoiesis, cancer metastasis, and HIV infection...
2017: Frontiers in Neuroscience
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