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https://www.readbyqxmd.com/read/29049716/bone-marrow-derived-cell-recruitment-to-the-neurosensory-retina-and-retinal-pigment-epithelial-cell-layer-following-subthreshold-retinal-phototherapy
#1
Sergio Caballero, David L Kent, Nilanjana Sengupta, Sergio Li Calzi, Lynn Shaw, Eleni Beli, Leni Moldovan, James M Dominguez, Ramana S Moorthy, Maria B Grant
Purpose: We investigated whether subthreshold retinal phototherapy (SRPT) was associated with recruitment of bone marrow (BM)-derived cells to the neurosensory retina (NSR) and RPE layer. Methods: GFP chimeric mice and wild-type (WT) mice were subjected to SRPT using a slit-lamp infrared laser. Duty cycles of 5%, 10%, 15%, and 20% (0.1 seconds, 250 mW, spot size 50 μm) with 30 applications were placed 50 to 100 μm from the optic disc. In adoptive transfer studies, GFP+ cells were given intravenously immediately after WT mice received SRPT...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049306/protein-structural-disorder-of-the-envelope-v3-loop-contributes-to-the-switch-in-human-immunodeficiency-virus-type-1-cell-tropism
#2
Xiaowei Jiang, Felix Feyertag, David L Robertson
Human immunodeficiency virus type 1 (HIV-1) envelope gp120 is partly an intrinsically disordered (unstructured/disordered) protein as it contains regions that do not fold into well-defined protein structures. These disordered regions play important roles in HIV's life cycle, particularly, V3 loop-dependent cell entry, which determines how the virus uses two coreceptors on immune cells, the chemokine receptors CCR5 (R5), CXCR4 (X4) or both (R5X4 virus). Most infecting HIV-1 variants utilise CCR5, while a switch to CXCR4-use occurs in the majority of infections...
2017: PloS One
https://www.readbyqxmd.com/read/29048610/evidence-of-lateral-transmission-of-aggressive-features-between-different-types-of-breast-cancer-cells
#3
Nancy Adriana Espinoza-Sánchez, Eduardo Vadillo, Juan Carlos Balandrán, Alberto Monroy-García, Rosana Pelayo, Ezequiel M Fuentes-Pananá
Breast cancer (BrC) is a major public health problem worldwide. The intra-tumoral heterogeneity and tumor cell plasticity importantly contribute to disease progression and treatment failure. However, the dynamic interactions between different tumor clones, as well as their contribution to tumor aggressiveness are still poorly understood. In this study, we provide evidence of a lateral transmission of aggressive features between aggressive and non-aggressive tumor cells, consisting of gain of expression of cancer stem cell markers, increased expression of CXCL12 receptors CXCR4 and CXCR7 and increased invasiveness in response to CXCL12, which correlated with high levels of secretion of pro-inflammatory mediators G-CSF, GM-CSF, MCP-1, IL-8 and metalloproteinases 1 and 2 by the aggressive cells...
September 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29040423/title-therapeutic-strategies-utilising-sdf-1%C3%AE-in-ischaemic-cardiomyopathy
#4
Oliver J Ziff, Daniel I Bromage, Derek M Yellon, Sean M Davidson
Heart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Alleviating and repairing cardiac injury associated with myocardial infarction (MI) is key to improving this burden. Homing signals mobilise and recruit stem cells to the ischaemic myocardium where they exert beneficial paracrine effects. The chemoattractant cytokine SDF-1α and its associated receptor CXCR4 are upregulated after MI and appear to be important in this context. Activation of CXCR4 promotes both cardiomyocyte survival and stem cell migration towards the infarcted myocardium...
October 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29037940/hyperbaric-oxygen-treatment-effects-on-in-vitro-cultured-umbilical-cord-blood-cd34-cells
#5
Kiang Yien Cheung, Abigale Berry, Dandan Li, Omar S Aljitawi
BACKGROUND AIMS: Umbilical cord blood (UCB) provides an alternative source for hematopoietic stem/progenitor cells (HSPCs) in the treatment of hematological malignancies. However, clinical usage is limited due to the low quantity of HSPCs in each unit of cord blood and defects in bone marrow homing. Hyperbaric oxygen (HBO) is among the more recently explored methods used to improve UCB homing and engraftment. HBO works by lowering the host erythropoietin before UCB infusion to facilitate UCB HSPC homing, because such UCB cells are not directly exposed to HBO...
October 13, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29036438/a-selective-sphingosine-1-phosphate-receptor-1-agonist-sew-2871-aggravates-gastric-cancer-by-recruiting-myeloid-derived-suppressor-cells
#6
Yujing Zhou, Feng Guo
The immune status of tumor microenvironment in gastric cancer is poorly understood, which limits the development of novel strategies in this field. Sphingosine-1-phosphate (S1P) acts as an immune modulator, but the role of S1P in gastric cancer is elusive. Here, we aim to investigate S1P receptor 1 (S1P1)-mediated effect of S1P in gastric cancer. We generated a xenograft mouse model and used SEW-2871, a S1P1 specific agonist to activate S1P1 signaling. Tumor-infiltrating lymphocytes (TILs) were isolated and analyzed using flow cytometry...
October 3, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29035436/cardioprotective-effect-of-the-sdf-1%C3%AE-cxcr4-axis-in-ischemic-postconditioning-in-isolated-rat-hearts
#7
Jeong Su Kim, Youngho Jang, June Hong Kim, Yong Hyun Park, Sun Ae Hwang, Jun Kim, Sung Ryul Lee, Zhelong Xu, Changill Ban, Kyohan Ahn, Kook Jin Chun
BACKGROUND AND OBJECTIVES: Information about the role of the stromal cell-derived factor-1α (SDF-1α)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1α/CXCR4 signaling pathway is directly involved in the cardioprotective effect of IPOC. METHODS: Isolated rat hearts were divided into four groups. The control group was subjected to 30-min of regional ischemia and 2-hour of reperfusion (n=12)...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29033304/epigenetic-activation-of-pro-angiogenic-signaling-pathways-in-human-endothelial-progenitors-increases-vasculogenesis
#8
Sylvain Fraineau, Carmen G Palii, Brian McNeill, Morten Ritso, William C Shelley, Nutan Prasain, Alphonse Chu, Elodie Vion, Kristy Rieck, Sharmin Nilufar, Theodore J Perkins, Michael A Rudnicki, David S Allan, Mervin C Yoder, Erik J Suuronen, Marjorie Brand
Human endothelial colony-forming cells (ECFCs) represent a promising source of adult stem cells for vascular repair, yet their regenerative capacity is limited. Here, we set out to understand the molecular mechanism restricting the repair function of ECFCs. We found that key pro-angiogenic pathways are repressed in ECFCs due to the presence of bivalent (H3K27me3/H3K4me3) epigenetic marks, which decreases the cells' regenerative potential. Importantly, ex vivo treatment with a combination of epigenetic drugs that resolves bivalent marks toward the transcriptionally active H3K4me3 state leads to the simultaneous activation of multiple pro-angiogenic signaling pathways (VEGFR, CXCR4, WNT, NOTCH, SHH)...
October 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29032612/correlation-between-cxcr4-cxcr7-cxcl12-chemokine-axis-expression-and-prognosis-in-lymph-node-positive-lung-cancer-patients
#9
Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara
The CXCR4/CXCR7/CXCL12 chemokine axis plays important roles in the migration of tumor cells during cancer development by modulating site-specific distant metastasis including to regional lymph nodes. We investigated the correlation of these chemokine expressions to prognosis in lymph-node-positive non-small-cell lung cancer (NSCLC) patients. A total of 140 surgically resected specimens of primary site (PS) and metastatic lymph nodes (MLN) of NSCLC involving hilar and/or mediastinal lymph nodes (N1-2) were collected...
October 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/29032338/an-analysis-of-suppressing-migratory-effect-on-human-urinary-bladder-cancer-cell-line-by-silencing-of-snail-1
#10
Shima Salehi, Behzad Mansoori, Ali Mohammadi, Sadaf Davoudian, Seyed Mohammad Hossein Musavi Shenas, Neda Shajari, Jafar Majidi, Behzad Baradaran
BACKGROUND: Snail-1 actively participates in tumor progression, invasion, and migration. Targeting snail-1 expression can suppress the EMT process in cancer. The aim of this study was to investigate the effect of snail1 silencing on urinary bladder cancer. METHODS: Quantitative RT-PCR was used to detect snail-1 and other related metastatic genes expression following siRNA knockdown in urinary bladder cancer EJ-138 cells. The protein level of snail1 was assessed by Western blot...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29026158/ginsenoside-rb1-prevents-homocysteine-induced-epc-dysfunction-via-vegf-p38mapk-and-sdf-1-cxcr4-activation
#11
Tao-Hua Lan, Dan-Ping Xu, Man-Ting Huang, Ju-Xian Song, Huan-Lin Wu, Min Li
Hyperhomocystinemia (HHcy) is known as an independent risk factor for cardiovascular disease. Our previous study showed that ginsenoside Rb1, the major active constituent of ginseng, prevents homocysteine (Hcy)-induced endothelial damage. However, the role of ginsenoside Rb1 in Hcy-induced dysfunction in endothelial progenitor cells (EPCs) remains unknown. In the study, we found that ginsenoside Rb1 reversed the Hcy-induced impairment of adhesive and migratory ability in EPCs which were significantly abolished by CXCR4 antagonist AMD3100 and VEGFR2 inhibitor SU5416...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025291/-waldenstr%C3%A3-m-s-macroglobulinemia-and-its-individualized-therapy-options
#12
Zsuzsanna Szemlaky, Gábor Mikala
Waldenström's macroglobulinaemia is a form of lymphoplasmocytic lymphoma that preferentially localizes to the bone marrow and causes a special syndrome characterized by monoclonal IgM hypersecretion. Recent results point to the fact that this disease has at least three different pathobiological forms with different clinical presentation. While mutations of MYD88 occur in 95-97% of the cases, there are CXCR4 mutations in 30-40%, ARID1A mutations in 17% and CD79B mutations in approximately 10% of afflicted individuals...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29022693/a-tri-layer-three-dimensional-hydrogel-composite-scaffold-containing-encapsulated-adipose-derived-stem-cells-promotes-bladder-reconstruction-via-sdf-1%C3%AE-cxcr4-pathway
#13
Dongdong Xiao, Hao Yan, Qiong Wang, Xiangguo Lv, Ming Zhang, Yang Zhao, Zhe Zhou, Jiping Xu, Qian Sun, Kang Sun, Wei Li, Mujun Lu
Bladder acellular matrix graft-alginate di-aldehyde-gelatin hydrogel-silk mesh (BAMG-HS) encapsulated with adipose-derived stem cells (ASCs) was evaluated in a rat model of augmentation cystoplasty, including BAMG-HS-ASCs (n = 18, subgroup n = 6 for 2, 4 and 12 weeks), acellular BAMG-HS (n = 6 for 12 weeks) and cystotomy control (n = 6 for 12 weeks) groups. Equipped with good cytocompatibility and superior mechanical properties (elastic modulus: 5.33 ± 0.96 MPa, maximum load: 28.90 ± 0.69 N), BAMG-HS acted a tri-layer "sandwich" scaffold with minimal interference in systemic homeostasis...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29022185/biological-pathological-functions-of-the-cxcl12-cxcr4-cxcr7-axes-in-the-pathogenesis-of-bladder-cancer
#14
REVIEW
Alireza Nazari, Hossein Khorramdelazad, Gholamhossein Hassanshahi
CXC chemokine ligand 12 (CXCL12) is an important member of the CXC subfamily of chemokines, and has been extensively studied in various human body organs and systems, both in physiological and clinical states. Ligation of CXCL12 to CXCR4 and CXCR7 as its receptors on peripheral immune cells gives rise to pleiotropic activities. CXCL12 itself is a highly effective chemoattractant which conservatively attracts lymphocytes and monocytes, whereas there exists no evidence to show attraction for neutrophils. CXCL12 regulates inflammation, neo-vascularization, metastasis, and tumor growth, phenomena which are all pivotally involved in cancer development and further metastasis...
October 11, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29020982/the-prognostic-value-of-c-x-c-motif-chemokine-receptor-4-in-patients-with-sporadic-malignant-peripheral-nerve-sheath-tumors
#15
Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou, Ji-Long Yang
BACKGROUND: Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor (MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values...
October 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29020646/hiv-1-subtype-crf01_ae-and-b-differ-in-utilization-of-low-levels-of-ccr5-maraviroc-susceptibility-and-potential-n-glycosylation-sites
#16
Anjali Joshi, Emily K Cox, Melina J Sedano, Erin B Punke, Raphael Tc Lee, Sebastian Maurer-Stroh, Palvinder Kaur, Oon Tek Ng, Himanshu Garg
HIV subtypes not only predominate in different geographical regions but also differ in key phenotypic characteristics. To determine if genotypic and/or phenotypic differences in the Envelope (Env) glycoprotein can explain subtype related differences, we cloned 37 full length Envs from Subtype B and AE HIV infected individuals from Singapore. Our data demonstrates that CRF01_AE Envs have lower Potential N Glycosylation Sites and higher risk of ×4 development. Phenotypically, CRF01_AE were less infectious than subtype B Envs in cells expressing low levels of CCR5...
October 8, 2017: Virology
https://www.readbyqxmd.com/read/29017963/the-role-of-cxcl12-in-tumor-microenvironment
#17
REVIEW
Wenfang Meng, Shihang Xue, Ye Chen
The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment. The interaction of CXCL12 and its receptors subsequently excite the downstream signaling pathways to affect tumor angiogenesis, tumor cell proliferation and chemoresistance, and thus represents a potential target for cancer therapy...
October 7, 2017: Gene
https://www.readbyqxmd.com/read/29016745/cxcl12-cxcr4-signaling-plays-an-essential-role-in-proper-patterning-of-aortic-arch-and-pulmonary-arteries
#18
Bo-Gyeong Kim, Yong Hwan Kim, Edward L Stanley, Eva M Garrido-Martin, Young Jae Lee, S Paul Oh
Aims: Chemokine CXCL12 (stromal derived factor 1: SDF1) has been shown to play important roles in various processes of cardiovascular development. In recent avian studies, CXCL12 signaling has been implicated in guidance of cardiac neural crest cells for their participation in the development of outflow tract and cardiac septum. The goal of this study is to investigate the extent to which CXCL12 signaling contribute to the development of aortic arch and pulmonary arteries in mammals. Methods and Results: Novel Cxcl12 -LacZ reporter and conditional alleles were generated...
September 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28994112/celastrol-attenuates-pain-and-cartilage-damage-via-sdf-1-cxcr4-signalling-pathway-in-osteoarthritis-rats
#19
Weifeng Wang, Chengzhi Ha, Tao Lin, Dawei Wang, Yuanhe Wang, Mingzhi Gong
OBJECTIVES: Celastrol has attracted wide interests for its anticancer and anti-inflammation properties, and studies have demonstrated that celastrol negatively modulates the stromal cell-derived factor-1 (SDF-1) and receptor C-X-C chemokine receptor type 4 (CXCR4) signalling. We aim in this study to investigate the effects of celastrol in osteoarthritis (OA) in vivo and explored the underlying molecular mechanisms. METHODS: We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments...
October 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28991373/novel-enriched-pathways-in-superficial-malignant-peripheral-nerve-sheath-tumors-mpnst-and-spindle-desmoplastic-melanomas-sdm
#20
George Jour, Nicole K Andeen, Rami Al -Rohil, Phyu P Aung, Meenakshi Mehrotra, Dzifa Duose, Benjamin Hoch, Zolt Argenyi, Rajyalakshmi Luthra, Ignacio I Wistuba, Victor G Prieto
Superficial malignant peripheral nerve sheath tumor (MPNST) is a rare, soft tissue neoplasm that shares morphological features and some molecular events with spindle and desmoplastic melanoma (SDM). Herein we sought to identify molecular targets for therapy using targeted RNA/DNA sequencing and gene expression of key immunological players. DNA and RNA from formalin-fixed, paraffin-embedded (FFPE) tissue were extracted and processed. Massive high-throughput deep parallel sequencing was performed using the Oncomine comprehensive panel enabling detection of relevant SNVs, CNVs, gene fusions, and indels from 143 unique genes on the Ion torrent sequencer for clinical trial research programs...
October 9, 2017: Journal of Pathology
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