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https://www.readbyqxmd.com/read/29134673/modified-dixon-based-renal-dynamic-contrast-enhanced-mri-facilitates-automated-registration-and-perfusion-analysis
#1
Anneloes de Boer, Tim Leiner, Eva E Vink, Peter J Blankestijn, Cornelis A T van den Berg
PURPOSE: Renal dynamic contrast-enhanced (DCE) MRI provides information on renal perfusion and filtration. However, clinical implementation is hampered by challenges in postprocessing as a result of misalignment of the kidneys due to respiration. We propose to perform automated image registration using the fat-only images derived from a modified Dixon reconstruction of a dual-echo acquisition because these provide consistent contrast over the dynamic series. METHODS: DCE data of 10 hypertensive patients was used...
November 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#2
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 7, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29121542/risk-factors-for-three-month-mortality-after-discharge-in-a-cohort-of-non-oncologic-hospitalized-elderly-patients-results-from-the-reposi-study
#3
Luca Pasina, Laura Cortesi, Mara Tiraboschi, Alessandro Nobili, Giovanna Lanzo, Mauro Tettamanti, Carlotta Franchi, Pier Mannuccio Mannucci, Silvia Ghidoni, Andrea Assolari, Antonio Brucato
BACKGROUND: Short-term prognosis, e.g. mortality at three months, has many important implications in planning the overall management of patients, particularly non-oncologic patients in order to avoid futile practices. The aims of this study were: i) to investigate the risk of three-month mortality after discharge from internal medicine and geriatric wards of non-oncologic patients with at least one of the following conditions: permanent bedridden status during the hospital stay; severely reduced kidney function; hypoalbuminemia; hospital admissions in the previous six months; severe dementia; ii) to establish the absolute risk difference of three-month mortality of bedridden compared to non-bedridden patients...
November 6, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29105594/tolvaptan-in-later-stage-autosomal-dominant-polycystic-kidney-disease
#4
Vicente E Torres, Arlene B Chapman, Olivier Devuyst, Ron T Gansevoort, Ronald D Perrone, Gary Koch, John Ouyang, Robert D McQuade, Jaime D Blais, Frank S Czerwiec, Olga Sergeyeva
Background In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, ≥60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed the growth in total kidney volume and the decline in the estimated glomerular filtration rate (GFR) but also caused more elevations in aminotransferase and bilirubin levels. The efficacy and safety of tolvaptan in patients with later-stage ADPKD are unknown. Methods We conducted a phase 3, randomized withdrawal, multicenter, placebo-controlled, double-blind trial...
November 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29063462/the-role-of-microalbuminuria-as-a-predictor-of-subclinical-cardiovascular-events-in-rheumatoid-arthritis-patients-and-its-relation-to-disease-activity
#5
D W Nada, S El Morsy, M H Abu-Zaid, M A Aboelhawa, Mohammad A Zakaria, E A El Sheikh, R A Gaber
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers...
October 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29050174/-effects-of-modified-three-step-procedure-for-anatrophic-nephrolithotomy-in-the-treatment-of-complex-staghorn-renal-calculi
#6
C L Yang, W Wang, W E Zhou, Y P Xue, B Q Wang, H B Nie, W L Hu
Objective: To investigate the effects of modified three-step procedure for anatrophic nephrolithotomy in the treatment of complex staghorn renal calculi. Methods: A total of 22 patients with complex staghorn renal calculi between June 2013 and June 2016 at Department of Urology in Guangzhou General Hospital of Guangzhou Military Command were retrospective analyzed. There were 13 males and 9 females, ranging from 35 to 62 years old with mean age of 47 years. There were 17 patients with dull pain, and 5 patients who were found through physical examinations...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29049415/effect-of-diacerein-on-renal-function-and-inflammatory-cytokines-in-participants-with-type-2-diabetes-mellitus-and-chronic-kidney-disease-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Fabiana Piovesan, Glaucia S Tres, Leila B Moreira, Michael E Andrades, Hugo K Lisboa, Sandra C Fuchs
Diacerein seems to improve metabolic control and reduce inflammatory marker levels in individuals with type 2 diabetes mellitus (Type 2 DM), but for participants with chronic kidney disease (CKD) its effect is unknown. This study aimed to evaluate the effect of diacerein vs. placebo on urinary albumin/creatinine ratio (ACR), glomerular filtration rate (GFR), and inflammatory cytokines in type 2 DM participants with CKD. Blood pressure (BP) and metabolic control were secondary outcomes. This randomized, placebo-controlled, parallel trial of adjuvant treatment of type 2 DM with diacerein enrolled seventy-two participants with CKD, aged 30-80 years, with glycated hemoglobin levels from 53-97 mmol/mol (7...
2017: PloS One
https://www.readbyqxmd.com/read/29048228/predictive-factors-for-achieving-superior-pentafecta-outcomes-following-robot-assisted-partial-nephrectomy-in-patients-with-localized-renal-cell-carcinoma
#8
Minyong Kang, In-Hyuck Gong, Hwi Jun Park, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Seong Il Seo
PURPOSE: To examine the perioperative outcomes following robot-assisted partial nephrectomy (RAPN) in patients with localized renal cell carcinoma (RCC) and to identify the predictors of Pentafecta achievement following RAPN. MATERIALS AND METHODS: We retrospectively analyzed the data from 362 patients with RCC who underwent RAPN from 2008 to 2016. The criteria for Pentafecta achievement was defined as the Trifecta [warm ischemia time (WIT) ≤ 25 minutes, negative surgical margin, and no significant perioperative complications]; with the addition of renal function preservation, including over 90% preservation of the estimated-glomerular filtration rate (e-GFR); and no stage upgrade of chronic kidney disease at 1 year after surgery...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29042456/effects-of-two-immunosuppressive-treatment-protocols-for-iga-nephropathy
#9
Thomas Rauen, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Harm Peters, Urs Benck, Peter R Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes F E Mann, Ralf-Dieter Hilgers, Jürgen Floege
The role of immunosuppression in IgA nephropathy (IgAN) is controversial. In the Supportive Versus Immunosuppressive Therapy for the Treatment of Progressive IgA Nephropathy (STOP-IgAN) Trial, 162 patients with IgAN and proteinuria >0.75 g/d after 6 months of optimized supportive care were randomized into two groups: continued supportive care or additional immunosuppression (GFR≥60 ml/min per 1.73 m(2): 6-month corticosteroid monotherapy; GFR=30-59 ml/min per 1.73 m(2): cyclophosphamide for 3 months followed by azathioprine plus oral prednisolone)...
October 17, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29039834/-renal-function-in-patients-receiving-long-term-warfarin-therapy-a-five-year-prospective-follow-up
#10
O A Zemlyanskaya, E S Kropacheva, A B Dobrovolsky, E P Panchenko
AIM: To investigate the prognostic value of renal function and to estimate glomerular filtration rate (GFR) changes during a 5-year follow-up of patients receiving warfarin therapy. SUBJECTS AND METHODS: 200 patients (124 men, 76 women) mainly from a group at high risk for thromboembolic events (mean CHA2DS2-VASc scores, 3.25±1.89) were examined. The patients' mean age was 62.3±9.4 years; the follow-up period was 5 years. 74% of the patients received warfarin monotherapy (international normalized ratio (INR) 2...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29034081/renal-impairment-in-stroke-patients-a-comparison-between-the-haemorrhagic-and-ischemic-variants
#11
Pratyush Shrestha, Shalima Thapa, Shikher Shrestha, Subash Lohani, Suresh Bk, Oscar MacCormac, Lekhjung Thapa, Upendra Prasad Devkota
Background: Renal impairment is regularly seen in hospitalized stroke patients, affecting the outcome of patients, as well as causing difficulties in their management. A prospective cohort study was conducted to assess the trend of renal function in hospitalized ischemic and haemorrhagic stroke patients. The incidence of renal impairment in these subgroups, the contributing factors and the need for renal replacement in renal impaired patients was evaluated. Methods: Alternate day renal function testing was performed in hospitalized stroke patients...
2017: F1000Research
https://www.readbyqxmd.com/read/29026688/establishing-the-presence-or-absence-of-chronic-kidney-disease-uses-and-limitations-of-formulas-estimating-the-glomerular-filtration-rate
#12
REVIEW
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas
The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course...
September 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/29023314/renal-dysfunction-and-cirrhosis
#13
François Durand, Jody C Olson, Mitra K Nadim
PURPOSE OF REVIEW: Hepatorenal syndrome (HRS) does not represent the predominant phenotype of acute kidney injury (AKI) in cirrhosis. Early recognition of HRS helps initiate appropriate therapy. The aims of this review are to present redefinition of AKI, to list new biomarkers, to report recent data on vasopressors in HRS and to propose criteria for simultaneous liver and kidney transplantation (SLKT). RECENT FINDINGS: Urine output, which was not part of the definition of AKI might be reconsidered as it has an independent prognostic value...
December 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28978800/new-insights-on-glomerular-hyperfiltration-a-japanese-autopsy-study
#14
Go Kanzaki, Victor G Puelles, Luise A Cullen-McEwen, Wendy E Hoy, Yusuke Okabayashi, Nobuo Tsuboi, Akira Shimizu, Kate M Denton, Michael D Hughson, Takashi Yokoo, John F Bertram
It has been suggested that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease (CKD). The incidence of CKD in Japan is among the highest in the world, but the reasons remain unclear. We estimated total nephron (glomerular) number (NglomTOTAL) as well as numbers of nonsclerosed (NglomNSG) and globally sclerosed glomeruli (NglomGSG), and the mean volume of nonsclerosed glomeruli (VglomNSG) in Japanese normotensive, hypertensive, and CKD subjects and investigated associations between these parameters and estimated glomerular filtration rate (eGFR)...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28971980/metabolomic-alterations-associated-with-cause-of-ckd
#15
Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh
BACKGROUND AND OBJECTIVES: Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different physiologic processes underlying CKD development and progression. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: Metabolites were quantified from serum samples of participants in the Modification of Diet in Renal Disease (MDRD) Study, a randomized controlled trial of dietary protein restriction and BP control, using untargeted reverse phase ultraperformance liquid chromatography tandem mass spectrometry quantification...
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28951038/losartan-therapy-decreases-albuminuria-with-stable-glomerular-filtration-and-permselectivity-in-sickle-cell-anemia
#16
Marianne E Yee, Peter A Lane, David R Archer, Clinton H Joiner, James R Eckman, Antonio Guasch
Sickle cell nephropathy begins with hyperfiltration and microalbuminuria and may progress to renal failure. The aim of this study was to determine the effects of losartan on glomerular function and albumin excretion in sickle cell anemia (SCA). Individuals with SCA on hydroxyurea with persistent albuminuria were enrolled in a 1-year study of losartan. Glomerular filtration rate (GFR) measured by iohexol clearance, albumin excretion rate (AER), and fractional clearance of dextran were assessed at baseline, short-term (1-2month), and long-term (≥12month) intervals...
September 21, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28944160/strategies-for-assessing-gfr-and-albuminuria-in-the-living-kidney-donor-evaluation
#17
Lesley A Inker, Naya Huang, Andrew S Levey
PURPOSE OF REVIEW: The international guideline development group Kidney Disease Improving Global Outcomes (KDIGO) recently published a comprehensive set of recommendations for living donor evaluation which contains a new framework for decision making in the evaluation of kidney donor candidates. RECENT FINDINGS: The guidelines recommend that decisions to accept or decline a candidate donor should be based on incorporation of multiple sources of information pertaining to the donor candidate's likelihood of serious adverse outcomes after donation...
March 2017: Current Transplantation Reports
https://www.readbyqxmd.com/read/28939943/accumulation-of-uraemic-toxins-is-reflected-only-partially-by-estimated-gfr-in-paediatric-patients-with-chronic-kidney-disease
#18
Evelien Snauwaert, Wim Van Biesen, Ann Raes, Els Holvoet, Griet Glorieux, Koen Van Hoeck, Maria Van Dyck, Nathalie Godefroid, Raymond Vanholder, Sanne Roels, Johan Vande Walle, Sunny Eloot
BACKGROUND: Chronic kidney disease (CKD) in childhood is characterised by the accumulation of uraemic toxins resulting in a multisystem disorder that has a negative impact on quality of life. Childhood CKD is predominantly defined by a decrease in glomerular filtration rate, estimated (eGFR) by a single serum measurement of endogenous biomarkers, e.g. creatinine. The objective of this study was to evaluate how accurately eGFR predicts the concentration of uraemic toxins in a paediatric CKD cohort...
September 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28924138/perioperative-ketorolac-use-a-potential-risk-factor-for-renal-dysfunction-after-live-donor-nephrectomy
#19
Kazuhiro Takahashi, Anita K Patel, Shunji Nagai, Mohamed Safwan, Krishna G Putchakayala, William J Kane, Lauren E Malinzak, Jason E Denny, Atsushi Yoshida, Dean Y Kim
BACKGROUND Ketorolac is a nonsteroidal anti-inflammatory drug indicated for pain control after surgeries in many fields. The aim of this study was to evaluate the impact of ketorolac use after live-donor nephrectomy (LDN). MATERIAL AND METHODS We reviewed data on 251 patients who underwent laparoscopic LDN from April 2008 to March 2016. Ketorolac was given to 167 patients intraoperatively or postoperatively within 24 h after LDN. Glomerular filtration rate (GFR) percentage was defined as postoperative GFR/preoperative GFR...
September 19, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28914962/impaired-phosphate-tolerance-revealed-with-an-acute-oral-challenge
#20
Mandy E Turner, Christine A White, Wilma M Hopman, Emilie C Ward, Paul S Jeronimo, Michael A Adams, Rachel M Holden
Elevated serum phosphate is consistently linked with cardiovascular disease (CVD) events and mortality in the setting of normal and impaired kidney function. However, serum phosphate does not often exceed the upper limit of normal until glomerular filtration rate (GFR) falls below 30 mL/min/m(2) . It was hypothesized that the response to an oral, bioavailable phosphate load will unmask impaired phosphate tolerance, a maladaptation not revealed by baseline serum phosphate concentrations. In this study rats with varying kidney function as well as normo-phosphatemic human subjects, with inulin-measured GFR (13...
September 15, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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