keyword
MENU ▼
Read by QxMD icon Read
search

e GFR

keyword
https://www.readbyqxmd.com/read/29775204/effects-of-%C3%AE-tocotrienol-on-ochratoxin-a-induced-nephrotoxicity-in-rats
#1
Sara Damiano, Luigi Navas, Patrizia Lombari, Serena Montagnaro, Iris M Forte, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
Ochratoxin A (OTA), is a natural contaminant of the food chain worldwide involved in the development of different type of cancers in animals and humans. Several studies suggested that oxidative damage might contribute to increase the cytotoxicity and carcinogenicity capabilities of OTA. The aim of this study was to evaluate the possible protective effect of δ-tocotrienol (Delta), a natural form of vitamin E, against OTA-induced nephrotoxicity. Male Sprague-Dawley rats were treated with OTA and/or Delta by gavage for 14 days...
May 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29774462/combining-gfr-estimates-from-cystatin-c-and-creatinine-what-is-the-optimal-mix
#2
Emil den Bakker, Reinoud Gemke, Joanna A E van Wijk, Isabelle Hubeek, Birgit Stoffel-Wagner, Arend Bökenkamp
BACKGROUND: Combining estimated glomerular filtration rate (eGFR) equations based on creatinine and cystatin C has been shown to improve the accuracy of GFR estimation. This study aims to optimize this strategy for height-independent GFR estimation in children. METHODS: Retrospective study of 408 inulin clearance tests with simultaneous International Federation of Clinical Chemistry-calibrated measurements of creatinine, cystatin C, and urea in children (mean age 12...
May 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29768260/carboplatin-dosing-accuracy-by-estimation-of-glomerular-filtration-versus-creatinuria-in-cancer-patients
#3
Noiver Graciano Vera, Luis Pino Villarreal, Jenny Ureña Vargas
BACKGROUND: The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula with the best performance. METHODS: Patients admitted between 2011 and 2017 and diagnosed with ovarian, endometrial, lung, esophageal, or testicular cancer were assessed retrospectively...
May 16, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29751620/kidney-response-to-the-spectrum-of-diet-induced-acid-stress
#4
Nimrit Goraya, Donald E Wesson
Chronic ingestion of the acid (H⁺)-producing diets that are typical of developed societies appears to pose a long-term threat to kidney health. Mechanisms employed by kidneys to excrete this high dietary H⁺ load appear to cause long-term kidney injury when deployed over many years. In addition, cumulative urine H⁺ excretion is less than the cumulative increment in dietary H⁺, consistent with H⁺ retention. This H⁺ retention associated with the described high dietary H⁺ worsens as the glomerular filtration rate (GFR) declines which further exacerbates kidney injury...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29725632/urinary-biomarkers-to-identify-autosomal-dominant-polycystic-kidney-disease-patients-with-a-high-likelihood-of-disease-progression
#5
A Lianne Messchendorp, Esther Meijer, Wendy E Boertien, Gerwin E Engels, Niek F Casteleijn, Edwin M Spithoven, Monique Losekoot, Johannes G M Burgerhof, Dorien J M Peters, Ron T Gansevoort
Introduction: The variable disease course of autosomal dominant polycystic kidney disease (ADPKD) makes it important to develop biomarkers that can predict disease progression, from a patient perspective and to select patients for renoprotective treatment. We therefore investigated whether easy-to-measure urinary biomarkers are associated with disease progression and have additional value over that of conventional risk markers. Methods: At baseline, inflammatory, glomerular, and tubular damage markers were measured in 24-hour urine collections (albumin, IgG, kidney injury molecule-1 (KIM-1), N -acetyl-β-d-glucosaminidase (NAG), β2 microglobulin (β2MG), heart-type fatty acid binding protein (HFABP), macrophage migration inhibitory factor (MIF), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein-1 (MCP-1)...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29721615/image-guided-thermal-ablation-for-non-resectable-recurrence-of-renal-cell-cancer-following-nephrectomy-clinical-experience-with-eleven-patients
#6
Wenhui Zhou, Sanna E Herwald, Raul N Uppot, Ronald S Arellano
PURPOSE: To assess the feasibility, safety and clinical outcomes of image-guided percutaneous thermal ablation as salvage therapy for local recurrence of renal cell carcinoma (RCC) in patients initially treated surgically with curative intent. MATERIALS AND METHODS: A retrospective review of 11 consecutive patients (M/F = 8:3, mean age = 76 years) who underwent computed tomography (CT)-guided thermal ablation for locally recurrent RCC after partial (72%, 8/11) or radical nephrectomy (28%, 3/11) with a mean time to recurrence of 48 months (range 2-156)...
May 2, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29714040/mitoprotection-preserves-the-renal-vasculature-in-porcine-metabolic-syndrome
#7
Alfonso Eirin, Ahmad F Hedayat, Christopher M Ferguson, Stephen C Textor, Amir Lerman, Lilach O Lerman
NEW FINDINGS: What is the central question of this study? We hypothesized that chronic mitoprotection would decrease renal vascular remodeling and dysfunction in swine metabolic syndrome. What is the main finding and its importance? This study shows that experimental metabolic syndrome exerts renal microvascular and endothelial cell mitochondrial injury, which were attenuated by mitoprotection, underscoring the contribution of mitochondrial injury to the pathogenesis of metabolic syndrome-induced vascular damage...
April 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29692933/murine-nephrotoxic-nephritis-as-a-model-of-chronic-kidney-disease
#8
M K E Ougaard, P H Kvist, H E Jensen, C Hess, I Rune, H Søndergaard
Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD parameters including albuminuria, glomerular filtration rate (GFR), mesangial expansion, and renal fibrosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29684616/serum-fibrinogen-predicts-diabetic-esrd-in-patients-with-type-2-diabetes-mellitus
#9
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN. METHODS: A total of 174 patients with T2DM and biopsy-proven DN were enrolled...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29678268/development-of-a-screening-tool-to-predict-chronic-kidney-disease-risk-in-post-nephrectomy-living-kidney-donors
#10
J S Park, H K Ahn, J Na, H H Lee, Y E Yoon, M G Yoon, W K Han
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR) <60 mL/min/1...
April 17, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29676846/generic-sofosbuvir-based-direct-acting-antivirals-in-hepatitis-c-virus-infected-patients-with-chronic-kidney-disease
#11
Manoj Kumar Sharma, Suman Lata Nayak, Ekta Gupta, Ashish Kataria, Shiv K Sarin
BACKGROUND & AIMS: There is scant data on use of sofosbuvir containing directly acting anti-viral (DAA) regimens in chronic kidney disease (CKD) patients. Recently generic versions of DAAs have become available in low income countries including India. The aim of this study was to study the efficacy and safety of generic sofosbuvir in combination with generic ribavirin, ledipasvir, or daclatasvir in HCV infected patients with CKD including patients with advanced CKD (CKD stage 4 or 5 with an estimated glomerular filtration rate (GFR) <30 mL/min or those on dialysis)...
April 20, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29664922/patterns-of-emergency-department-utilization-by-patients-on-chronic-dialysis-a-population-based-study
#12
Paul Komenda, Navdeep Tangri, Evan Klajncar, Amanda Eng, Michelle Di Nella, Brett Hiebert, Trevor Strome, Ricardo Lobato de Faria, James M Zacharias, Mauro Verrelli, Manish M Sood, Claudio Rigatto
IMPORTANCE: Patients on dialysis are often elderly and frail, with multiple comorbid conditions, and are heavy users of Emergency Department (ED) services. However, objective data on the frequency and pattern of ED utilization by dialysis patients are sparse. Such data could identify periods of highest risk for ED visits and inform health systems interventions to mitigate these risks and improve outcomes. OBJECTIVE: To describe the pattern and frequency of presentation to ER by dialysis patients...
2018: PloS One
https://www.readbyqxmd.com/read/29656903/improving-the-prognosis-of-patients-with-severely-decreased-glomerular-filtration-rate-ckd-g4-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#13
Kai-Uwe Eckardt, Nisha Bansal, Josef Coresh, Marie Evans, Morgan E Grams, Charles A Herzog, Matthew T James, Hiddo J L Heerspink, Carol A Pollock, Paul E Stevens, Manjula Kurella Tamura, Marcello A Tonelli, David C Wheeler, Wolfgang C Winkelmayer, Michael Cheung, Brenda R Hemmelgarn
Patients with severely decreased glomerular filtration rate (GFR) (i.e., chronic kidney disease [CKD] G4+) are at increased risk for kidney failure, cardiovascular disease (CVD) events (including heart failure), and death. However, little is known about the variability of outcomes and optimal therapeutic strategies, including initiation of kidney replacement therapy (KRT). Kidney Disease: Improving Global Outcomes (KDIGO) organized a Controversies Conference with an international expert group in December 2016 to address this gap in knowledge...
April 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29652115/analysis-on-influencing-factors-of-abnormal-renal-function-in-elderly-patients-with-type-2-diabetes-mellitus
#14
Tao Chai, Dawei Zhang, Zhongxin Li
BACKGROUND: To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS: The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29651290/anti-transforming-growth-factor-%C3%AE-igg-elicits-a-dual-effect-on-calcium-oxalate-crystallization-and-progressive-nephrocalcinosis-related-chronic-kidney-disease
#15
Stefanie Steiger, Julia Felicitas Grill, Qiuyue Ma, Tobias Bäuerle, Jutta Jordan, Michaela Smolle, Claudia Böhland, Maciej Lech, Hans-Joachim Anders
Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney stone disease or nephrocalcinosis-related chronic kidney disease (CKD). We hypothesized that immunoglobulins can modulate CaOx microcrystal formation and crystal growth and that therefore, biological IgG-based drugs designed to specifically target disease modifying proteins would elicit a dual effect on the outcome of CaOx-related crystallopathies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29623766/a-retrospective-analysis-of-the-mixed-venous-oxygen-saturation-as-the-target-for-systemic-blood-flow-control-during-cardiopulmonary-bypass
#16
Staffan Svenmarker, Matias Hannuksela, Michael Haney
OBJECTIVES: The patient's body surface area serves as the traditional reference for the determination of systemic blood flow during cardiopulmonary bypass (CPB). New strategies refer to different algorithms of oxygen delivery. This study reports on the mixed venous oxygen saturation (Sv O2 ) as the target for systemic blood flow control. We hypothesise that an Sv O2 >75% (Sv O2 75) is associated with better preservation of renal function and improved short-term survival. METHODS: This retrospective, 10-year, observational study analysed 6945 consecutive cardiac surgical cases requiring CPB...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29605094/predicting-timing-of-clinical-outcomes-in-patients-with-chronic-kidney-disease-and-severely-decreased-glomerular-filtration-rate
#17
Morgan E Grams, Yingying Sang, Shoshana H Ballew, Juan Jesus Carrero, Ognjenka Djurdjev, Hiddo J L Heerspink, Kevin Ho, Sadayoshi Ito, Angharad Marks, David Naimark, Danielle M Nash, Sankar D Navaneethan, Mark Sarnak, Benedicte Stengel, Frank L J Visseren, Angela Yee-Moon Wang, Anna Köttgen, Andrew S Levey, Mark Woodward, Kai-Uwe Eckardt, Brenda Hemmelgarn, Josef Coresh
Patients with chronic kidney disease and severely decreased glomerular filtration rate (GFR) are at high risk for kidney failure, cardiovascular disease (CVD) and death. Accurate estimates of risk and timing of these clinical outcomes could guide patient counseling and therapy. Therefore, we developed models using data of 264,296 individuals in 30 countries participating in the international Chronic Kidney Disease Prognosis Consortium with estimated GFR (eGFR)s under 30 ml/min/1.73m2 . Median participant eGFR and urine albumin-to-creatinine ratio were 24 ml/min/1...
March 24, 2018: Kidney International
https://www.readbyqxmd.com/read/29602293/swimming-exercise-demonstrates-advantages-over-running-exercise-in-reducing-proteinuria-and-glomerulosclerosis-in-spontaneously-hypertensive-rats
#18
N L Totou, S S Moura, D B Coelho, E C Oliveira, L K Becker, W G Lima
Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and were trained for 8 weeks under similar intensities (60 min/day)...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29570216/cardiac-resynchronization-therapy-a-comparative-analysis-of-mortality-in-african-americans-and-caucasians
#19
John M Fontaine, Sona M Franklin, Gilbert Essilfie, Lilian E Ahiable
BACKGROUND: Cardiac resynchronization therapy (CRT) is recommended in patients with heart failure, reduced left ventricular ejection fraction and a prolonged QRS duration. African-Americans are underrepresented in clinical trials and CRT is underutilized, consequently, the benefits and outcomes of CRT are not well-defined. METHODS: We evaluated 294 patients, determined survival using Kaplan-Meier analysis, and used Cox proportional hazards regression model to determine predictors of mortality...
March 23, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29566163/target-organ-damage-and-target-systolic-blood-pressure-in-clinical-practice-the-campania-salute-network
#20
Andrea D'Amato, Costantino Mancusi, Maria Angela Losi, Raffaele Izzo, Maria Immacolata Arnone, Grazia Canciello, Salvatore Senese, Nicola De Luca, Giovanni de Simone, Bruno Trimarco
BACKGROUND: Lowering systolic blood pressure (SBP) below the conventional threshold (140 mm Hg) reduces left ventricular (LV) hypertrophy and incident cardiovascular (CV) events. We assessed whether different thresholds of SBP as the average value during follow-up (FU) have different impact on changes in target organ damage (TOD). METHODS: From the Campania Salute Network registry, we selected 4,148 hypertensive patients with average SBP-FU <140 mm Hg, and without history of prevalent CV or chronic kidney disease (i...
March 16, 2018: American Journal of Hypertension
keyword
keyword
33212
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"