keyword
https://read.qxmd.com/read/38530931/imaging-markers-from-population-wide-mri-based-automated-kidney-segmentation-an-analysis-of-data-from-the-german-national-cohort-nako-gesundheitsstudie
#1
Elias Kellner, Peggy Sekula, Jan Lipovsek, Maximilian Russe, Harald Horbach, Christopher L Schlett, Matthias Nauck, Henry Völzke, Thomas Kroencke, Stefanie Bette, Hans-Ulrich Kauczor, Thomas Keil, Tobias Pischon, Iris M Heid, Annette Peters, Thoralf Niendorf, Wolfgang Lieb, Fabian Bamberg, Martin Büchert, Wilfried Reichardt, Marco Reisert, Anna Köttgen
BACKGROUND: Population-wide research on potential new imaging biomarkers of the kidney depends on accurate automated segmentation of the kidney and its compartments (cortex, medulla, and sinus). METHODS: We developed a robust deep-learning framework for kidney (sub-)segmentation based on a hierarchical, three-dimensional convolutional neural network (CNN) that was optimized for multi-scale problems of combined localization and segmentation. We applied the CNN to abdominal magnetic resonance images from the population-based German National Cohort (NAKO) study...
May 3, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38526935/association-of-left-ventricular-diastolic-dysfunction-with-inflammatory-activity-renal-dysfunction-and-liver-related-mortality-in-patients-with-cirrhosis-and-ascites
#2
JOURNAL ARTICLE
Georgios Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Lampros Lakkas, Spiridon Tsiouris, Xanthi Xourgia, Georgios S Markopoulos, Lefkothea Dova, Haralampos Milionis
Left ventricular diastolic dysfunction (LVDD) is the predominant cardiac abnormality in cirrhosis. We investigated the association of LVDD with systemic inflammation and its impact on renal function, occurrence of hepatorenal syndrome (HRS) and survival in patients with cirrhosis and ascites. We prospectively enrolled 215 patients with cirrhosis and ascites. We evaluated the diagnosis and grading of LVDD by Doppler echocardiography, inflammatory markers, systemic hemodynamics, vasoactive factors, radioisotope-assessed renal function and blood flow, HRS development and liver-related mortality...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38519234/oligonephronia-another-piece-in-the-ckdu-jigsaw
#3
JOURNAL ARTICLE
Wendy E Hoy, John F Bertram
Rates of chronic kidney disease of unknown etiology are high in Aguascalientes, Mexico. Kidneys of adolescents are small by ultrasonography, compatible with oligonephronia, whereas proteinuria and higher estimated glomerular filtration rates and blood pressures among those with relatively higher kidney volumes probably flag relatively greater degrees of compensatory hypertrophy. Glomerulomegaly and podocytopathy, and later segmental glomerulosclerosis in biopsies, suggest a cascade driven by nephron deficiency...
April 2024: Kidney International
https://read.qxmd.com/read/38508877/renin-angiotensin-aldosterone-system-blockers-effect-in-chronic-kidney-disease-progression-in-hypertensive-elderly-patients-without-proteinuria-proercan-trial
#4
JOURNAL ARTICLE
A M García-Prieto, Ú Verdalles, A P de José, D Arroyo, I Aragoncillo, D Barbieri, R E Camacho, M Goicoechea
INTRODUCTION: Evidence about nefroprotective effect with RAAS blockers in elderly patients with chronic kidney disease (CKD) without proteinuria is lacking. The primary outcome of our study is to evaluate the impact of RAAS blockers in CKD progression in elderly patients without proteinuria. MATERIALS AND METHODS: Multicenter open-label, randomized controlled clinical trial including patients over 65 year-old with hypertension and CKD stages 3-4 without proteinuria...
March 19, 2024: Hipertensión y Riesgo Vascular
https://read.qxmd.com/read/38508632/finerenone-cardiovascular-and-kidney-outcomes-by-age-and-sex-fidelity-post-hoc-analysis-of-two-phase-3-multicentre-double-blind-trials
#5
RANDOMIZED CONTROLLED TRIAL
Shweta Bansal, Maria E F Canziani, Rita Birne, Stefan D Anker, George L Bakris, Gerasimos Filippatos, Peter Rossing, Luis M Ruilope, Alfredo E Farjat, Peter Kolkhof, Andrea Lage, Meike Brinker, Bertram Pitt
OBJECTIVES: This study aimed to evaluate the efficacy and safety of finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, on cardiovascular and kidney outcomes by age and/or sex. DESIGN: FIDELITY post hoc analysis; median follow-up of 3 years. SETTING: FIDELITY: a prespecified analysis of the FIDELIO-DKD and FIGARO-DKD trials. PARTICIPANTS: Adults with type 2 diabetes and chronic kidney disease receiving optimised renin-angiotensin system inhibitors (N=13 026)...
March 19, 2024: BMJ Open
https://read.qxmd.com/read/38498672/risk-factors-for-lower-renal-compensation-after-nephrectomy-an-analysis-of-living-kidney-donors-in-an-amazonian-cohort
#6
JOURNAL ARTICLE
Luan Moraes Ferreira, Gisela Gomes Batista, Leoneide Érica Maduro Bouillet, Emanuel Pinheiro Esposito
INTRODUCTION: Living donor kidney transplantation is considered the ideal renal replacement therapy because it has a lower complication rate and allows an efficient response to the high demand for grafts in the healthcare system. Careful selection and adequate monitoring of donors is a key element in transplantation. Individuals at greater risk of developing kidney dysfunction after nephrectomy must be identified. OBJECTIVE: To identify risk factors associated with a renal compensation rate (CR) below 70% 12 months after nephrectomy...
2024: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://read.qxmd.com/read/38497953/arteriovenous-access-for-hemodialysis-a-review
#7
JOURNAL ARTICLE
Charmaine E Lok, Thomas S Huber, Ani Orchanian-Cheff, Dheeraj K Rajan
IMPORTANCE: Hemodialysis requires reliable vascular access to the patient's blood circulation, such as an arteriovenous access in the form of an autogenous arteriovenous fistula or nonautogenous arteriovenous graft. This Review addresses key issues associated with the construction and maintenance of hemodialysis arteriovenous access. OBSERVATIONS: All patients with kidney failure should have an individualized strategy (known as Patient Life-Plan, Access Needs, or PLAN) for kidney replacement therapy and dialysis access, including contingency plans for access failure...
March 18, 2024: JAMA
https://read.qxmd.com/read/38496522/comprehensive-mapping-of-sensory-and-sympathetic-innervation-of-the-developing-kidney
#8
Pierre-Emmanuel Y N'Guetta, Sarah R McLarnon, Adrien Tassou, Matan Geron, Sepenta Shirvan, Rose Z Hill, Grégory Scherrer, Lori L O'Brien
The kidney functions as a finely tuned sensor to balance body fluid composition and filter out waste through complex coordinated mechanisms. This versatility requires tight neural control, with innervating efferent nerves playing a crucial role in regulating blood flow, glomerular filtration rate, water and sodium reabsorption, and renin release. In turn sensory afferents provide feedback to the central nervous system for the modulation of cardiovascular function. However, the cells targeted by sensory afferents and the physiological sensing mechanisms remain poorly characterized...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38496471/prevalence-of-biomarkers-and-associated-factors-for-chronic-kidney-disease-in-adult-diabetic-out-patients-in-a-tertiary-hospital-in-eastern-uganda-a-cross-sectional-study
#9
Moses Kirya, Denis Bwayo, Michael E Otim, Paul Bukhota Mutoo, J Peter M Masaba, Ambrose Okibure, Richard Katuramu
Background Chronic kidney disease (CKD) is one of the most common complications of Diabetes Mellitus (DM). DM contributes to about 66% of CKD cases globally. CKiiiD results in increased morbidity and mortality and advanced stages often require renal replacement therapy that is unaffordable for the majority of the patients. Developing countries have scanty data regarding CKD burden in diabetic patients. OBJECTIVES This study aimed at determining the prevalence of biomarkers for CKD and associated factors among diabetic patients attending the adult diabetic clinic of Mbale Regional Referral Hospital (MRRH)...
March 5, 2024: Research Square
https://read.qxmd.com/read/38495599/serum-metabolomic-markers-of-protein-rich-foods-and-incident-ckd-results-from-the-atherosclerosis-risk-in-communities-study
#10
JOURNAL ARTICLE
Lauren Bernard, Jingsha Chen, Hyunju Kim, Kari E Wong, Lyn M Steffen, Bing Yu, Eric Boerwinkle, Andrew S Levey, Morgan E Grams, Eugene P Rhee, Casey M Rebholz
RATIONALE & OBJECTIVE: While urine excretion of nitrogen estimates the total protein intake, biomarkers of specific dietary protein sources have been sparsely studied. Using untargeted metabolomics, this study aimed to identify serum metabolomic markers of 6 protein-rich foods and to examine whether dietary protein-related metabolites are associated with incident chronic kidney disease (CKD). STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: A total of 3,726 participants from the Atherosclerosis Risk in Communities study without CKD at baseline...
April 2024: Kidney medicine
https://read.qxmd.com/read/38487634/linear-association-of-compound-dietary-antioxidant-index-with-hyperlipidemia-a-cross-sectional-study
#11
JOURNAL ARTICLE
Haoran Zhou, Tianshu Li, Jie Li, Dongdong Zheng, Jie Yang, Xin Zhuang
BACKGROUND: There is growing evidence that antioxidant-rich diets may prevent hyperlipidemia. However, the relationship between the Composite Dietary Antioxidant Index (CDAI) and hyperlipidemia is unclear. The CDAI is a composite score reflecting the antioxidant content of an individual's diet, and this study aimed to investigate the relationship between CDAI and hyperlipidemia. METHODS: The study used the 2003-2018 National Health and Nutrition Examination Survey (NHANES) database for cross-sectional analyses and included 27,626 participants aged 20 years and older...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38484869/trajectories-of-physical-resilience-among-older-veterans-with-stage-4-ckd
#12
JOURNAL ARTICLE
C Barrett Bowling, Theodore S Z Berkowitz, Brett T Burrows, Jessica E Ma, Heather E Whitson, Battista Smith, Steven D Crowley, Virginia Wang, Matthew L Maciejewski, Maren K Olsen
RATIONALE & OBJECTIVE: Although functional impairment is common among older adults with chronic kidney disease (CKD), functional reserve before an acute health event and physical resilience after have not been characterized in this population. The purpose of this study was to identify distinct patterns of physical function before and after an acute health event among older Veterans with Stage 4 CKD. STUDY DESIGN: Prospective cohort study. SETTING: & Participants: National sample of Veterans ≥70 years of age with an estimated glomerular filtration rate (eGFR) <30 ml/min/1...
March 12, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38481516/familial-variability-of-disease-severity-in-adult-patients-with-adpkd
#13
JOURNAL ARTICLE
Elhussein A E Elhassan, Patrick O'Kelly, Kane E Collins, Omri Teltsh, Francesca Ciurli, Susan L Murray, Claire Kennedy, Stephen F Madden, Katherine A Benson, Gianpiero L Cavalleri, Peter J Conlon
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic nephropathy and has striking familial variability of disease severity. METHODS: To better comprehend familial phenotypic variability, we analyzed clinical and pedigree data on 92 unrelated ADPKD kindreds with ≥2 affected individuals ( N  = 292) from an Irish population. All probands underwent genetic sequencing. Age at onset of kidney failure (KF), decline in estimated glomerular filtration rate (eGFR), predicting renal outcome in polycystic kidney disease (PROPKD) score, and imaging criteria were used to assess and grade disease severity as mild, intermediate, or severe...
March 2024: KI Reports
https://read.qxmd.com/read/38464892/magnetic-resonance-imaging-based-kidney-volume-assessment-for-risk-stratification-in-pediatric-autosomal-dominant-polycystic-kidney-disease
#14
JOURNAL ARTICLE
Kubra Yilmaz, Seha Saygili, Nur Canpolat, Ozlem Akgun-Dogan, Zeynep Nagehan Yuruk Yildirim, Rumeysa Yasemin Cicek-Oksuz, Huseyin Adil Oner, Bagdagul Aksu, Nazli Gulsum Akyel, Ozge Oguzhan-Hamis, Hasan Dursun, Sevgi Yavuz, Neslihan Cicek, Nurver Akinci, Esra Karabag Yilmaz, Ayse Agbas, Ahmet Nevzat Nayir, Dildar Konukoglu, Sebuh Kurugoglu, Lale Sever, Salim Caliskan
INTRODUCTION: In the pediatric context, most children with autosomal dominant polycystic kidney disease (ADPKD) maintain a normal glomerular filtration rate (GFR) despite underlying structural kidney damage, highlighting the critical need for early intervention and predictive markers. Due to the inverse relationship between kidney volume and kidney function, risk assessments have been presented on the basis of kidney volume. The aim of this study was to use magnetic resonance imaging (MRI)-based kidney volume assessment for risk stratification in pediatric ADPKD and to investigate clinical and genetic differences among risk groups...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38463588/dysregulation-of-kidney-proteases-in-the-pathogenesis-of-hypertension-following-unilateral-nephrectomy-in-juvenile-mice
#15
JOURNAL ARTICLE
Rasha Aly, Yunus E Dogan, Niharika Bala, Carlos Lugo, Seena Darwish, Lawrence Shoemaker, Abdel A Alli
BACKGROUND: Unliteral nephrectomy (UNX) results in the reduction of kidney mass. The remaining kidney undergoes compensatory renal growth via hypertrophy of the glomeruli and renal tubules to maintain a normal glomerular filtration rate (GFR). These compensatory mechanisms result in increased capillary pressure and glomerular hyperfiltration to increase single nephron GFR. Over time, hyperfiltration may lead to kidney scarring and the development of hypertension. OBJECTIVES: The first objective of this study was to test the hypothesis that a 50% reduction in functioning nephrons in juvenile mice leads to increased blood pressure over a 24-hour phase...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38462800/-biomarkers-of-inflammation-in-predicting-the-outcomes-of-heart-failure-of-ischemic-etiology-the-results-of-factor-analysis
#16
JOURNAL ARTICLE
A A Garganeeva, E A Kuzheleva, O V Tukish, M Yu Kondratiev, K N Vitt, S L Andreev, O N Ogurkova
AIM: To study the prognostic significance of inflammatory biomarkers in patients with chronic heart failure (CHF) and stenotic multivessel coronary atherosclerosis, with determination of the biomarker separate set that reflects subclinical inflammation and is associated with the development of cardiovascular complications during prospective observation. MATERIAL AND METHODS: A prospective observational study was conducted that included 80 patients with CHF and ischemic heart disease who were scheduled for coronary artery bypass grafting (CABG) during their current hospitalization...
February 29, 2024: Kardiologiia
https://read.qxmd.com/read/38460948/physical-exercise-a-polypill-against-chronic-kidney-disease
#17
JOURNAL ARTICLE
Pedro L Valenzuela, Adrián Castillo-García, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Alejandro Lucia
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function)...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38460211/vitamin-d-and-behavioral-disorders-in-older-adults-results-from-the-clip-study
#18
JOURNAL ARTICLE
Lucie Gilbert, Alexis Bourgeais, Spyridon N Karras, Duygu Gezen-Ak, Erdinç Dursun, Cédric Annweiler
OBJECTIVES: Vitamin D is involved in brain health and function. Our objective was to determine whether vitamin D deficiency was associated with behavioral disorders in geriatric patients. DESIGN: The observational cross-sectional CLIP (Cognition and LIPophilic vitamins) study. The report followed the STROBE statement. SETTING: Geriatric acute care unit in a tertiary university hospital in France for 3 months at the end of winter and beginning of spring...
March 8, 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38459950/microbial-analysis-in-chronic-rhinosinusitis-patients-with-chronic-kidney-disease-and-end-stage-renal-disease
#19
JOURNAL ARTICLE
Sheng-Wei Lo, Meng-Chang Ding, Yao-Te Tsai, Ming-Shao Tsai, Chia-Yen Liu, Cheng-Ming Hsu, Yao-Hsu Yang, Geng-He Chang
INTRODUCTION: This study aimed to elucidate the bacterial profile of chronic rhinosinusitis (CRS) in patients with end-stage renal disease (ESRD) and chronic kidney disease (CKD) compared with nonrenal patients, guiding antibiotic selection for clinicians. METHODS: We retrospectively analyzed 13,906 inpatients from the Chang Gung Research Database who underwent sinus surgery (2004-2018). Patients were categorized into ESRD-CRS, CKD-CRS, and non-CKD-CRS based on the estimated glomerular filtration rate...
March 9, 2024: Laryngoscope
https://read.qxmd.com/read/38458377/a-holistic-framework-for-the-evaluation-of-kidney-function-in-a-gender-diverse-landscape
#20
JOURNAL ARTICLE
Keila Turino Miranda, Dina N Greene, David Collister, Matthew D Krasowski, Sofia B Ahmed, Lauren R Cirrincione, Sylvia E Rosas, Nathalie Saad, Christina C Pierre
The most commonly used equations to estimate glomerular filtration rate incorporate a binary male-female sex coefficient, which has important implications for the care of transgender, gender-diverse, and non-binary (TGD) people. Whether "sex assigned at birth" or a binary "gender identity" is most appropriate for the computation of estimated glomerular filtration rate (eGFR) is unknown. Furthermore, the use of gender-affirming hormone therapy (GAHT) for the development of physical changes to align TGD people with their affirmed gender is increasingly common, and may result in changes in serum creatinine and cystatin C, biomarkers commonly used to estimate glomerular filtration rate...
March 6, 2024: American Journal of Kidney Diseases
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