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systemic inflammation

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https://www.readbyqxmd.com/read/29046054/porphyromonas-gingivalis-lipopolysaccharide-stimulation-in-human-periodontal-ligament-stem-cells-role-of-epigenetic-modifications-to-the-inflammation
#1
Francesca Diomede, Soundara Rajan Thangavelu, Ilaria Merciaro, Monica D'Orazio, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani
Periodontitis is a chronic oral inflammatory disease produced by bacteria. Gingival retraction and bone and connective tissues resorption are the hallmarks of this disease. Chronic periodontitis may contribute to the risk of onset or progression of neuroinflammatory pathological conditions, such as Alzheimer's disease. The main goal of the present study was to investigate if the role of epigenetic modulations is involved in periodontitis using human periodontal ligament stem cells (hPDLSCs) as an in vitro model system...
August 25, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29046030/-immunopathology-of-chronic-obstructive-pulmonary-disease
#2
Nora Ernestina Martínez-Aguilar, María Eugenia Vargas-Camaño, Rogelio Ramsés Hernández-Pliego, Genny Margarita Chaia-Semerena, María Rosario Pérez-Chavira
Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigenetic-environmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045979/-changes-of-serum-krebs-von-den-lungen-6-levels-in-interstitial-lung-disease-associated-with-dermatomyositis-and-secondary-sj%C3%A3-gren-s-syndrome-a-case-report
#3
J F Yu, Y B Jin, J He, Y An, Z G Li
Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by various patterns of inflammation and fibrosis in the interstitium of the lung. The underlying pathogenesis of ILDs is complex and associated with multiple rheumatologic conditions, such as systemic sclerosis, rheumatoid arthritis, pollymyositis and dermatomyositis, Sjögren's syndrome, and systemic lupus erythematosus. As the disease progresses, excessive pulmonary fibrosis impairs alveolar gas exchange and damages pulmonary function...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045972/-acetylsalicylic-acid-treatment-enhanced-immunomodulatory-function-of-mesenchymal-stem-cells-derived-from-gingiva
#4
R L Yang, T T Yu, Y H Zhou
OBJECTIVE: To analyze the role of acetylsalicylic acid (ASA) in immunomodulation of mesenchymal stem cells derived from gingiva (GMSCs), and to explore the role of ASA in enhancing the immumomodulation of GMSCs and the capacity of GMSCs to treat immune disorders and the underlying mechanism. METHODS: Flow cytometry analysis were used to analyze the role of ASA in the expression of stem cells surface markers CD146, CD105, CD90, CD34 and CD45 in GMSCs,and the GMSCs proliferation was analyzed by 5-bromo-2-deoxyuridine (BrdU) staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045708/association-between-polycyclic-aromatic-hydrocarbon-exposure-and-peripheral-blood-mononuclear-cell-dna-damage-in-human-volunteers-during-fire-extinction-exercises
#5
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Per Axel Clausen, Julie Elbæk Pedersen, Mille Løhr, Ali Kermanizadeh, Steffen Loft, Niels Ebbehøj, Åse Marie Hansen, Peter Bøgh Pedersen, Ismo Kalevi Koponen, Eva-Carina Nørskov, Peter Møller, Ulla Vogel
This study investigated a number of biomarkers, associated with systemic inflammation as well as genotoxicity, in 53 young and healthy subjects participating in a course to become firefighters, while wearing personal protective equipment (PPE). The exposure period consisted of a 3-day training course where the subjects participated in various live-fire training exercises. The subjects were instructed to extinguish fires of either wood or wood with electrical cords and mattresses. The personal exposure was measured as dermal polycyclic aromatic hydrocarbon (PAH) concentrations and urinary excretion of 1-hydroxypyrene (1-OHP)...
October 13, 2017: Mutagenesis
https://www.readbyqxmd.com/read/29045618/cd27-co-stimulation-increases-the-abundance-of-regulatory-t-cells-and-reduces-atherosclerosis-in-hyperlipidaemic-mice
#6
Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Aims: The co-stimulatory receptor CD27 modulates responses of T cells, B cells, and NK cells. Various T cell subsets participate in atherogenesis. However, the role of CD27 in atherosclerosis remains unexplored. Methods and results: Here we investigated the effect of bone marrow-derived and systemic CD27 deficiency in Apolipoprotein E-deficient (Apoe-/-) mice in early and advanced stages of atherosclerosis. Lethally-irradiated Apoe-/- mice reconstituted with Cd27-/-Apoe-/- bone marrow and consuming an atherogenic diet displayed a markedly increased plaque size and lesional inflammation compared to mice receiving Cd27+/+Apoe-/- bone marrow...
October 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29045432/inflammatory-response-and-oxidative-stress-during-liver-resection
#7
Christoph Schwarz, Fabian Fitschek, David Bar-Or, Daniel A Klaus, Bianca Tudor, Edith Fleischmann, Georg Roth, Dietmar Tamandl, Thomas Wekerle, Michael Gnant, Martin Bodingbauer, Klaus Kaczirek
BACKGROUND: Postoperative complications are still a major concern after liver resection (LR). Systemic inflammation and deregulated reactive oxygen species during major abdominal surgery may impair outcome after hepatectomy. METHODS: Patients undergoing LR were included in this study (n = 40). Oxidative stress (OS) was measured peri- and post-operatively as static oxidation-reduction potential markers (sORP) and antioxidant capacity ORP (cORP) by using the RedoxSYS Diagnostic system...
2017: PloS One
https://www.readbyqxmd.com/read/29045346/autoimmune-hepatitis-and-aih-overlap-with-sclerosing-cholangitis-immunophenotype-markers-in-children-and-adolescents
#8
Priscila Menezes Ferri, Ana Cristina Simões E Silva, Karen Cecília de Lima Torres, Soraya Luiza Campos Silva, Diego Júnior Queiroga de Aquino, Maria Luísa Marques Ferreira, Eleonora Druve Tavares Fagundes, Débora Marques de Miranda, Alexandre Rodrigues Ferreira
OBJECTIVE: The pathophysiology of autoimmune hepatitis (AIH) may involve the activation of immune cells and changes in the expression of cellular markers. The aim of this study was to characterize the immunophenotype markers of lymphocytes and monocytes in the peripheral blood of children and adolescents with type 1 AIH and AIH overlap with sclerosing cholangitis (overlap syndrome, OS). METHODS: This is a cross-sectional study of 20 children and adolescents diagnosed with type 1 AIH and 19 with OS...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045335/angiotensin-converting-enzyme-2-and-renal-disease
#9
Vanessa R Williams, James W Scholey
PURPOSE OF REVIEW: The renin-angiotensin system (RAS) is a pivotal player in the physiology and pathophysiology of cardiovascular and renal systems. Discovery of angiotensin-converting enzyme 2 (ACE2), capable of cleaving RAS effector peptide angiotensin (Ang) II into biologically active Ang-(1-7), has increased the complexity of our knowledge of the RAS. ACE2 expression is abundant in the kidney and is thought to provide protection against injury. This review emphasizes current experimental and clinical findings that examine ACE2 in the context of kidney injury and its potential therapeutic impact for treatment of kidney disease...
October 16, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#10
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29044654/animal-models-of-neuroinflammation-secondary-to-acute-insults-originated-outside-the-brain
#11
REVIEW
Mike Yoshio Hamasaki, Marcel Cerqueira César Machado, Fabiano Pinheiro da Silva
The term "neuroinflammation" has been widely used to describe a series of acute or chronic conditions that cause inflammation in the central nervous system (CNS). Neurological damage can be a consequence of direct local injury or, secondary, of systemic or even distant inflammatory processes. In this respect, animal models have been developed to better understand the pathophysiology and, possibly, to evaluate more effective methods of treatment for these disorders. Animal models that promote alterations in blood-brain barrier permeability-the activation of microglia or astrocytes, modifications in neuropeptide expression, oxidative stress, increased apoptosis, release of inflammatory mediators, leukocyte infiltration, and brain edema-are likely to involve neuroinflammation and therefore can serve as useful models for human inflammatory CNS injury...
October 16, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29044530/gingival-tissue-an-extrasynovial-source-of-malondialdehyde-acetaldehyde-adducts-citrullinated-and-carbamylated-proteins
#12
R Bright, G M Thiele, J Manavis, T R Mikuls, J B Payne, P M Bartold
BACKGROUND AND OBJECTIVE: Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate that inflamed human gingival tissue provides an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins all of which are considered to be linked to the development of rheumatoid arthritis...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29044290/protease-activated-receptor-par-4-an-inducible-switch-between-thrombosis-and-vascular-inflammation
#13
Anke C Fender, Bernhard H Rauch, Tobias Geisler, Karsten Schrör
Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncontrolled PAR activation, however, can prevent timely resolution of inflammation, enhance thrombogenic endothelial function and drive adverse remodelling. The specific role of PAR-4 in thromboinflammatory vascular disease has been largely underestimated, given the relatively limited expression of PAR-4 in non-platelet cells under healthy conditions...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044209/cell-penetrating-interactomic-inhibition-of-nuclear-factor-kappa-b-in-a-mouse-model-of-postoperative-cognitive-dysfunction
#14
So Yeong Cheon, Jeong Min Kim, Eun Hee Kam, Chun-Chang Ho, Eun Jung Kim, Seungsoo Chung, Ji-Hyun Jeong, Diane Da-Hyun Lee, Sang-Won Lee, Bon-Nyeo Koo
Some patients experience impaired cognitive functioning after surgery, a phenomenon referred to as postoperative cognitive dysfunction (POCD). Signs of POCD are closely associated with the development of systemic or hippocampal inflammation. However, the precise pathophysiological mechanisms of prevention/treatment options for POCD still remain unclear. After injury, the transcriptional factor nuclear factor-kappa B (NF-κB) is thought to regulate or stimulate inflammation amplification. Therefore, we designed a cell-penetrating fusion protein called nt-p65-TMD, which inhibits NF-κB p65 activation by translocating into the nucleus...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044140/therapeutic-potential-of-bifidobacterium-breve-strain-a1-for-preventing-cognitive-impairment-in-alzheimer-s-disease
#15
Yodai Kobayashi, Hirosuke Sugahara, Kousuke Shimada, Eri Mitsuyama, Tetsuya Kuhara, Akihito Yasuoka, Takashi Kondo, Keiko Abe, Jin-Zhong Xiao
It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managing neurodegenerative disorders. In this study, we investigated the effects of oral administration of Bifidobacterium breve strain A1 (B. breve A1) on behavior and physiological processes in Alzheimer's disease (AD) model mice...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044081/retained-intraocular-iron-foreign-body-presenting-with-acute-retinal-necrosis
#16
Manavi D Sindal, Sabyasachi Sengupta, Dhaivat Vasavada, Sivaraman Balamurugan
We report an unusual case of retained metallic intraocular foreign body (IOFB) presenting with acute retinal necrosis (ARN). A healthy young man presented with signs of ARN including hypopyon, dense vitritis, and peripheral retinal necrosis following alleged history of trauma with a high-velocity projectile. After initial management of ARN with systemic antivirals, a retained metallic IOFB was identified and subsequently removed surgically. The patient was followed up for 12 months postoperatively and retained excellent vision without recurrence of the ARN...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044046/locally-extensive-meningoencephalitis-caused-by-miamiensis-avidus-syn-philasterides-dicentrarchi-in-a-zebra-shark
#17
Wen-Ta Li, Chieh Lo, Chen-Yi Su, Hsuan Kuo, Susanne Je-Han Lin, Hui-Wei Chang, Victor Fei Pang, Chian-Ren Jeng
Scuticociliatosis, caused by ciliated protozoa in the subclass Scuticociliatia of the phylum Ciliophora, can cause fatal disease in teleost fish species. However, information on scuticociliatosis in elasmobranchs is still scarce. In this report, we describe a case of locally extensive meningoencephalitis caused by Miamiensis avidus (syn. Philasterides dicentrarchi) in a 2 yr old captive zebra shark Stegostoma fasciatum. Granulocytic meningoencephalitis was observed through histological assessment. Inflammation was confined to the ventral aspect of the brain with a large number of ciliated protozoa, transforming into non-suppurative meningitis in the lateral aspect, and gradually vanished in the dorsal aspect...
October 18, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29043914/authors-reply-to-letter-to-the-editor-in-response-to-comment-on-durrani-et-al-s-adalimumab-for-ocular-inflammation
#18
Khayyam Durrani, John H Kempen, C Stephen Foster
No abstract text is available yet for this article.
October 18, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29043545/early-brain-injury-associated-with-systemic-inflammation-after-subarachnoid-hemorrhage
#19
Jude Savarraj, Kaushik Parsha, Georgene Hergenroeder, Sungho Ahn, Tiffany R Chang, Dong H Kim, H Alex Choi
BACKGROUND: Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) is defined as brain injury occurring within 72 h of aneurysmal rupture. Although EBI is the most significant predictor of outcomes after aSAH, its underlying pathophysiology is not well understood. We hypothesize that EBI after aSAH is associated with an increase in peripheral inflammation measured by cytokine expression levels and changes in associations between cytokines. METHODS: aSAH patients were enrolled into a prospective observational study and were assessed for markers of EBI: global cerebral edema (GCE), subarachnoid hemorrhage early brain edema score (SEBES), and Hunt-Hess grade...
October 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29043068/meta-fibrosis-links-positive-energy-balance-and-mitochondrial-metabolism-to-insulin-resistance
#20
REVIEW
Daniel S Lark, David H Wasserman
Obesity and insulin resistance often emerge from positive energy balance and generally are linked to low-grade inflammation. This low-grade inflammation has been called "meta-inflammation" because it is a consequence of the metabolic dysregulation that can accompany overnutrition. One means by which meta-inflammation is linked to insulin resistance is extracellular matrix expansion secondary to meta-inflammation, which we define here as "meta-fibrosis". The significance of meta-fibrosis is that it reflects a situation in which the extracellular matrix functions as a multi-level integrator of local (for example, mitochondrial reactive oxygen species production) and systemic (for example, inflammation) inputs that couple to cellular processes creating insulin resistance...
2017: F1000Research
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