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Anna Pawlik, Robert P Socha, Marie Hubalek Kalbacova, Grzegorz D Sulka
Nowadays, titanium and its alloys are the most commonly used implantable materials. The surface topography and chemistry of titanium-based implants are responsible for osseointegration. One of the methods to improve biocompatibility of Ti implants is a modification with sodium hydroxide (NaOH) or 3-aminopropyltriethoxysilane (APTES). In the present study, anodic titanium dioxide (ATO) layers were electrochemically fabricated, and then immersed in a NaOH solution or in NaOH and APTES solutions. The functionalized samples were characterized by using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS)...
July 6, 2018: Colloids and Surfaces. B, Biointerfaces
Marta Vannoni, Veronique Creach, Jon Barry, Dave Sheahan
Chlorination is a widely used antifouling method for freshwater and marine applications. Chlorine added to seawater reacts to form oxidants that are toxic to biofouling organisms. Further, the oxidants that result are short-lived, but may nevertheless affect non-target species in waterbodies receiving the antifouling effluent. This study evaluated the toxicity of chlorinated seawater (e.g. following sodium hypochlorite addition) on two different species of marine benthic diatoms (Achnanthes spp., and Navicula pelliculosa), which are representative of microphytobenthos communities - an important component in coastal habitats that may be exposed to chlorinated seawater...
June 25, 2018: Aquatic Toxicology
Nikita A Kuldyushev, Konstantin S Mineev, Antonina A Berkut, Steve Peigneur, Alexander S Arseniev, Jan Tytgat, Eugene V Grishin, Alexander A Vassilevski
Sodium channel alpha-toxins from scorpion venom (α-NaTx) inhibit the inactivation of voltage-gated sodium channels. We used solution NMR to investigate the structure of BeM9 toxin from Mesobuthus eupeus scorpion, a prototype α-NaTx classified as an "α-like" toxin due to its wide spectrum of activity on insect and mammalian channels. We identified a new motif that we named "arginine hand", whereby arginine side chain forms several hydrogen bonds with main chain atoms. The arginine hand was found in the "specificity module", a part of the molecule that dictates toxin selectivity; and just single arginine-to-lysine point mutation drastically changed BeM9 selectivity profile...
July 14, 2018: Proteins
Carlos J Aranda, Borja Ocón, María Arredondo-Amador, María Dolores Suárez, Antonio Zarzuelo, Walter J Chazin, Olga Martínez-Augustin, Fermín Sánchez de Medina
BACKGROUND AND PURPOSE: Calprotectin (CP) is a heterodimer composed of S100A8 and S100A9 that is highly abundant in neutrophils and monocytes/macrophages. Calprotectin fecal levels are used routinely to monitor inflammatory bowel disease activity. EXPERIMENTAL APPROACH: We aimed to assess the role of calprotectin in intestinal inflammation. The dextran sulfate sodium (DSS) model of colitis in mice was used. CP was administered at 50 or 100 μg·day-1 by the intrarectal or intraperitoneal route (50 μg·day-1 only)...
July 14, 2018: British Journal of Pharmacology
Xinbo Zhang
Sodium-organic batteries, which use organics as electrode materials for sodium ion batteries, are an attractive alternative to conventional lithium ion batteries for the next-generation sustainable and versatile energy storage devices due to the abundant sodium resources and environmental friendly organics. However, organics used in sodium ion batteries also encounter some issues such as low redox potential, high-solubility in electrolyte and low conductivity. In response, altering the aromatic system/attaching electron withdrawing groups, constructing polymer and incorporating conductive matrix are effective strategies...
July 14, 2018: Chemistry: a European Journal
Clemilson Berto-Júnior, Ana Paula Santos-Silva, Andrea Claudia Freitas Ferreira, Jones Bernades Graceli, Denise Pires de Carvalho, Paula Soares, Nelilma Correia Romeiro, Leandro Miranda-Alves
Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on reproduction, development, and cancer incidence, and it is highly used in the plastic industry. Bisphenol S (BPS) was proposed as an alternative to BPA since it has a similar structure and can be used to manufacture the same products. Some reports show that BPA interferes with thyroid function, but little is known about the involvement of BPS in thyroid function or how these molecules could possibly modulate at the same time the principal genes involved in thyroid physiology...
July 13, 2018: Environmental Science and Pollution Research International
Inneke Willekens, Stefaan J Vandecasteele, Kristof Verhoeven, Frank De Geeter
Erythromelalgia is a rare condition characterized by attacks of intensely painful, red and warm feet and/or hands. Symptoms typically are triggered by heat and relieved by cooling of the extremities. Primary cases are due to mutations in the gene for a sodium channel expressed in nociceptive and sympathetic ganglion neurons; secondary causes include blood disorders, infections, drugs, connective tissue diseases, neuropathic diseases, including diabetic neuropathy, and malignancies. We present bone scan findings in a case of erythromelalgia in an 18 years old student, in whom the symptoms developed suddenly...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Abdullah Al-Zaghal, Dani P Yellanki, Cyrus Ayubcha, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: This study was conducted to determine the role of computed tomography (CT)-based segmentation methodology to semi-quantify the degree of inflammation and reactive bone formation in the knee joints by fluorine-18-fluorodeoxyglucose (18 F-FDG) and 18 F-sodium fluoride positron emission tomography/CT (18 F-NaF PET/CT) imaging, respectively. Furthermore, we assessed the impact of aging and body mass index (BMI) on these biological responses. SUBJECTS AND METHODS: In this retrospective study, we examined a total of 97 subjects who had undergone both 18 F-FDG and 18 F-NaF PET/CT scanning...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Shuang-Quan Yu, Shuangtao Ma, Donna H Wang
This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. Intrathecal injection of RTX (1.8 μg/kg) to the levels of lower thoracic and upper lumbar spinal cord (T8-L3) increased mean arterial pressure (MAP) in rats fed a normal (NS, 1% NaCl) or high-sodium (HS, 8% NaCl) diet for 4 weeks compared to vehicle-treated rats (NS: 121 ± 2 vs...
July 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Muralidhar Allam, A K D Bhavani, Anwita Mudiraj, Nikhil Ranjan, Mallikarjuna Thippana, Phanithi Prakash Babu
A series of hybrid aza heterocycles containing pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazole scaffold were synthesized from 1,3-dipolar cycloaddition reaction of pyrazolopyrimidinone based alkyne with azides using Cu(II) catalyst in presence of sodium ascorbate and evaluated for their anticancer efficacy in vitro against C6 rat and U87 human glioma cell lines. These compounds induced a concentration dependent inhibition of C6 rat and U87 human glioma cell proliferation. Compound 5f arrested the cells at S-phase of the cell cycle and induced apoptosis in U87 GBM cell lines...
June 27, 2018: European Journal of Medicinal Chemistry
Gry Hulsart-Billström, Ram Kumar Selvaraju, Sergio Estrada, Mark Lubberink, Veronika Asplund, Kristoffer Bergman, Richard Marsell, Sune Larsson, Gunnar Antoni
Bone morphogenetic proteins (BMP's) are vital for bone and cartilage formation, where bone morphogenetic protein-2 (BMP-2) is acknowledged as a growth factor in osteoblast differentiation. However, uncontrolled delivery may result in adverse clinical effects. In this study we investigated the possibility for longitudinal and non-invasive monitoring of implanted [125 I]BMP-2 retention and its relation to ossification at the site of implantation. A unilateral critically sized femoral defect was produced in the left limb of rats while the right femur was retained intact as a paired reference control...
July 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Didier Majou, Souad Christieans
For cured meat products, nitrite is recognized for its antimicrobial effects against pathogenic bacteria, even though the specific inhibitory mechanisms are not well known. Nitrite contributes to oxidative stress by being the precursor of peroxynitrite (ONOO- ), which is the major strong oxidant. Thus, bacterial stress (highly pH-very low partial pressure of oxygen-dependent) is enhanced by the nitrate-nitrite-peroxynitrite system which is also highly pH- and low partial pressure of oxygen-dependent. Nitrite is a hurdle technology which effectiveness depends on several other hurdle technologies including sodium chloride (accelerating the autoxidation of oxymyoglobin and promote peroxynitrite formation), ascorbate (increasing ONOO- synthesis), and Aw...
July 9, 2018: Meat Science
Kelly Doran, Barbara Resnick, Hamzah Alghzawi, Shijun Zhu
BACKGROUND: Long-term care workers are at high risk for cardiovascular disease, in part because of their poor health habits. OBJECTIVE: The purpose of this study is to test the impact of the Worksite Heart Health Improvement Project (WHHIP) on subjective behavioral cardiovascular risk factors over time among long-term care staff. DESIGN: The WHHIP was a 12-month cluster randomized control trial conducted in four long-term care facilities. The exercise, nutrition, and stress management intervention lasted 9-months and was implemented during paid work time...
June 28, 2018: International Journal of Nursing Studies
Matheus D Baldissera, Carine F Souza, Antônio Francisco Igor M De Matos, Pedro Henrique Doleski, Bernardo Baldisserotto, Aleksandro S Da Silva, Silvia G Monteiro
Several evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations using mice as experimental model, as well as the involvement of blood-brain barrier (BBB) and brain neurotransmitters in these alterations. Thymol (20 and 40 mg/kg) significantly decrease latency time to inhibitory avoidance task when compared to control group, indicating a memory loss after 30 days of oral treatment...
July 8, 2018: Environmental Toxicology and Pharmacology
Xianhua Zhang, Congya Zhou, Yuanyuan Zhang, Shuangpeng Zhu, Xiaofeng Cai, Chunmiao Pan, Chuanzhen Wang, Suodi Zhai, Li Yang
A sensitive, accurate and rapid UHPLC-MS/MS method was developed and validated for the simultaneous determination of EVT201 and its two metabolites, Ro46-1927 and Ro18-5528, in human plasma. D6 -EVT201 was used as the internal standard (IS). Plasma samples were extracted using ethyl acetate after being alkalized with saturated sodium carbonate solution. Chromatographic separation was carried out on an Acquity BEH C18 column (2.1 × 50 mm, 1.7 μm) with a gradient mobile phase at a flow-rate of 0.50 mL/min...
June 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
Mason Greer, Cheng Chen, Soumyajit Mandal
In this work, low-field proton (1 H) and sodium (23 Na) relaxation and diffusion measurements are used to detect and classify different types of food products. A compact and low-cost system based on a small 0.5 T permanent magnet has been developed to autonomously authenticate such products. The system uses a simple but efficient double-tuned matching network suitable for 1 H/23 Na NMR. Various machine learning algorithms are used to classify food samples based on T1 -T2 and D-T2 data generated by the system, and the accuracy and prediction speed of these algorithms are studied in detail...
June 30, 2018: Journal of Magnetic Resonance
Shahabeddin Rezaei, Zohreh Mahmoudi, Ali Sheidaei, Zahra Aryan, Negar Mahmoudi, Kimiya Gohari, Moein Yoosefi, Mohammad J Hajipour, Arezou Dilmaghani-Marand, Mojdeh Soleimanzadehkhayat, Ali Gholami, Siamak Mirab Samiee, Ghobad Moradi, Bagher Larijani, Farshad Farzadfar
OBJECTIVE: In Iran, there has been no national report on salt intake based on laboratory measurements so far. Therefore, this study was conducted to measure salt intake among Iranian population at the national level. METHODS: In stepwise approach to conduct a surveillance survey 2016, 18 624 Iranian adults (25 years old and above), as a representative sample of Iranian adult population at national and subnational levels, underwent urine sodium measurement and were included in this study...
July 12, 2018: Journal of Hypertension
Kasper M Petersen, Niklas R Jørgensen, Søren Bøgevig, Tonny S Petersen, Thomas B Jensen, Kim P Dalhoff, Mikkel B Christensen
Background Intravenous lipid emulsion (ILE) is used to treat drug poisonings. The resultant hyperlipemia may affect laboratory tests but the consequences are poorly characterized. In a clinical trial we therefore investigated the effects of ILE on laboratory tests analyzed on common analytical platforms (Roche® cobas 8000 and SYSMEX® flow-cytometry). Methods Ten healthy participants each completed 4 trial days (two with ILE and two with placebo). ILE (5.25 mL/kg) was administered from 12.5 to 30 min from baseline...
July 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Caifu Dong, Jianwen Liang, Yanyan He, Chuanchuan Li, Xiaoxia Chen, Lijun Guo, Fang Tian, Yitai Qian, Liqiang Xu
Nickle sulfides as promising anode materials for sodium-ion batteries have attracted tremendous attention owing to their large specific capacity and good electrical conductivity. However, the relative large volume changes during the sodiation/desodiation process usually results in a fast capacity decay, poor cycling stability and sluggish electrode kinetics which hinder their practical applications. Herein, NiS1.03 porous hollow spheres (NiS1.03 PHSs) and porous NiS1.03 hollow cages (NiS1.03 PHCs) with high yiled are designed and selectively fabricated via a simple solvothermal and subsequent annealing approach...
July 13, 2018: ACS Nano
Jinqi Deng, Mingzhu Yang, Jing Wu, Wei Zhang, Xingyu Jiang
Immunoassays whose readouts rely on chemiluminescence are increasingly useful for a broad range of analytical applications, but they are rarely made into point-of-care (POC) format because of the complex reagents required (some reagents have to be stored in low temperatures, and some reagents have to be freshly made right before the assay). This study reports a self-contained chemiluminescent lateral flow assay (CLFA), which prestores all necessary reagents. This CLFA contains three parts: the normal lateral flow assay (LFA) strip, the chemiluminescence substrate pad, and the polycarbonate (PC) holder...
July 13, 2018: Analytical Chemistry
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