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https://www.readbyqxmd.com/read/28340473/enantiomers-of-triclabendazole-sulfoxide-analytical-and-semipreparative-hplc-separation-absolute-configuration-assignment-and-transformation-into-sodium-salt
#1
Rosella Ferretti, Simone Carradori, Paolo Guglielmi, Marco Pierini, Adriano Casulli, Roberto Cirilli
Direct HPLC separation of the enantiomers of triclabendazole sulfoxide (TCBZ-SO), which is the main metabolite of the anthelmintic drug triclabendazole, was carried out using the polysaccharide-based Chiralpak AS-H and Chiralpak IF-3 chiral stationary phases (CSPs). The chromatographic behaviour of both CSPs was evaluated and compared using normal-phase and reversed-phase eluents at different column temperatures. The eluent mixture of n-hexane-2-propanol-trifluoroacetic acid 70:30:0.1 (v/v/v) and a column temperature of 40°C were identified as the best operational conditions to carry out semipreparative enantioseparations on a 1-cm I...
March 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28340423/carbon-nanotube-impeded-transport-of-non-steroidal-anti-inflammatory-drugs-in-xiangjiang-sediments
#2
Jin Yan, Ji-Lai Gong, Guang-Ming Zeng, Biao Song, Peng Zhang, Hong-Yu Liu, Shuang-Yan Huan, Xiao-Dong Li
Carbon nanotubes (CNTs), usually with a superior affinity with organic chemicals, are expected to ultimately released to the environment through their manufacturing, usage, and eventual disposal, which will influence the mobility and environmental risk of nonsteroidal anti-inflammatory drugs (NSAIDs). In this study, batch and column experiments were performed to examine the effects of two kinds of multi-walled carbon nanotubes (MWCNTs: MWCNT2040, MWCNT0815) and one kind of single-walled carbon nanotubes (SWCNTs) on the environmental fate of two NSAIDs, paracetamol (PA) and diclofenac sodium (DS), in sediments...
March 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28340320/protective-effects-of-alpha-lipoic-acid-on-methotrexate-induced-oxidative-lung-injury-in-rats
#3
Huseyin Arpag, Mehmet Gül, Yusuf Aydemir, Nurhan Atilla, Birgül Yiğitcan, Tugrul Cakir, Cemal Polat, Özer Þehirli, Muhammet Sayan
OBJECTIVE: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. METHODS: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was performed with a single dose of MTX (20 mg/kg) to groups 2 and 3...
March 24, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28340295/response-of-catalase-of-the-mouse-primary-hepatocytes-to-sodium-dodecylbenzene-sulfonate-and-the-underlying-molecular-mechanisms
#4
Jing Wang, Jiaxi Wang, Lu Zhang, Rutao Liu, Wansong Zong
This study investigated the adverse effects of sodium dodecylbenzene sulfonates (SDBS) on the mouse primary hepatocytes by conducting cell viability, intracellular oxidative stress level and catalase (CAT) activity assays. It was shown that SDBS altered CAT activities, triggered oxidative stress, and thus exhibited cytotoxicity to the hepatocytes. Both the stimulation of intracellular CAT production and the inhibition of molecular CAT activity contributed to intracellular CAT activity change. Molecular mechanisms underlying CAT activity inhibition and structural changes were explored by isothermal titration calorimetry, multi-spectroscopy and molecular docking studies...
March 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28340239/hypertension-in-dialysis-patients-a-consensus-document-by-the-european-renal-and-cardiovascular-medicine-eureca-m-working-group-of-the-european-renal-association-european-dialysis-and-transplant-association-era-edta-and-the-hypertension-and-the-kidney-working
#5
Pantelis A Sarafidis, Alexandre Persu, Rajiv Agarwal, Michel Burnier, Peter de Leeuw, Charles J Ferro, Jean-Michel Halimi, Gunnar H Heine, Michel Jadoul, Faical Jarraya, Mehmet Kanbay, Francesca Mallamaci, Patrick B Mark, Alberto Ortiz, Gianfranco Parati, Roberto Pontremoli, Patrick Rossignol, Luis Ruilope, Patricia Van der Niepen, Raymond Vanholder, Marianne C Verhaar, Andrzej Wiecek, Gregoire Wuerzner, Gérard M London, Carmine Zoccali
In patients with end-stage renal disease (ESRD) treated with haemodialysis or peritoneal dialysis, hypertension is common and often poorly controlled. Blood pressure (BP) recordings obtained before or after haemodialysis display a J- or U-shaped association with cardiovascular events and survival, but this most likely reflects the low accuracy of these measurements and the peculiar haemodynamic setting related to dialysis treatment. Elevated BP detected by home or ambulatory BP monitoring is clearly associated with shorter survival...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28340151/effect-of-excess-dietary-fluoride-on-laying-performance-and-antioxidant-capacity-of-laying-hens
#6
L P Miao, M Y Zhou, X Y Zhang, C Yuan, X Y Dong, X T Zou
The objective of this study was to investigate the effects of excess dietary fluoride (F) on laying performance and antioxidant capacity of laying hens. A total of 576 laying hens, 51 wk old, was randomly divided into 6 groups, each of which included 6 replicates of 16 hens. Graded amounts of sodium fluoride (NaF) were added to the basal diet to achieve concentrations of 16 (control), 200, 400, 600, 800, and 1,000 mg/kg F, respectively. Dietary F at 1,000 mg/kg significantly decreased ADFI, laying rate, and average egg weight, and increased feed conversion ratio (FCR) (P < 0...
March 11, 2017: Poultry Science
https://www.readbyqxmd.com/read/28340057/long-term-outcome-of-pulmonary-vein-isolation-in-patients-with-paroxysmal-atrial-fibrillation-and-brugada-syndrome
#7
Giacomo Mugnai, Burak Hünük, Erwin Ströker, Diego Ruggiero, Hugo Enrique Coutino-Moreno, Ken Takarada, Valentina De Regibus, Rajin Choudhury, Juan Pablo Abugattas de Torres, Darragh Moran, Saverio Iacopino, Pasquale Filannino, Giulio Conte, Juan Sieira, Jan Poelaert, Stefan Beckers, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Aims: The therapeutical management of atrial fibrillation (AF) in the setting of Brugada syndrome (BS) might be challenging as many antiarrhythmic drugs (AADs) with sodium channel blocking properties might lead to to the development of ventricular arrhythmias. This study sought to evaluate the clinical outcome in a consecutive series of patients with BS having undergone pulmonary vein (PV) isolation by means of radiofrequency (RF) or cryoballoon (CB) ablation and the efficacy of catheter ablation for preventing inappropriate interventions delivered by implantable cardioverter defibrillators (ICD) on a 3-year follow up...
March 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339995/long-term-flecainide-therapy-in-type-3-long-qt-syndrome
#8
Ehud Chorin, Rivki Taub, Aron Medina, Nir Flint, Sami Viskin, Jesaia Benhorin
Aims: Type 3 long QT syndrome (LQT3) is caused by gain-of-function mutations in the cardiac sodium channel gene (SCN5A). Previous reports on the long-term use of sodium channel blockers in LQT3 are sparse. The objective of the current study was to evaluate the long-term safety and efficacy of flecainide therapy in patients with LQT3 who carry the D1790G SCN5A mutation. Methods and results: The study population comprised 30 D1790G carriers who were treated with flecainide and followed for 1-215 months (mean 145 ± 54 months, median 140 months)...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339773/effects-of-sodium-1-25-dihydroxyvitamin-d3-and-parathyroid-hormone-fragment-on-inorganic-p-absorption-and-type-iib-sodium-phosphate-cotransporter-expression-in-ligated-duodenal-loops-of-broilers
#9
X D Liao, H Q Suo, L Lu, Y X Hu, L Y Zhang, X G Luo
Three experiments were conducted with 22-day-old Arbor Acres male broilers to study the effects of Na+, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and parathyroid hormone fragment [PTH (1-34)] on inorganic P absorption and Type IIb sodium-phosphate cotransporter (NaP-IIb) mRNA and protein expression levels in ligated duodenal loops. The duodenal loops were perfused with solutions (pH = 6) containing zero, 50, or 150 mmol/L of Na+ as NaCl in Exp. 1, containing zero, 30, or 300 pmol/L of 1,25-(OH)2D3 in Exp. 2, or containing zero, 65, or 650 pmol/L of PTH (1-34) in Exp...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339658/acute-cell-volume-regulation-by-janus-kinase-2-mediated-sodium-hydrogen-exchange-activation-develops-at-the-late-one-cell-stage-in-mouse-preimplantation-embryos%C3%A2
#10
Baozeng Xu, Chenxi Zhou, Megan Meredith, Jay M Baltz
Early preimplantation embryos are extremely sensitive to dysregulation of cell volume, which can lead to developmental arrest. It was previously shown that mouse embryos at the two-cell stage respond to a cell volume decrease by quickly activating Na+/H+ exchange via a signaling mechanism that involves the tyrosine kinase Janus kinase 2 (JAK2). However, it was not known whether this mechanism is active at the one-cell stage, when embryos are most sensitive to perturbed cell volume. Na+/H+ exchanger activity elicited by an induced cell volume decrease was significantly lower at the mid one-cell stage than at the late one-cell stage or during the two-cell stage...
February 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339646/tgf-%C3%AE-receptor-inhibition-prevents-ventricular-fibrosis-in-a-mouse-model-of-progressive-cardiac-conduction-disease
#11
Mickael Derangeon, Jérôme Montnach, Cynthia Ore Cerpa, Benoit Jagu, Justine Patin, Gilles Toumaniantz, Aurore Girardeau, Christopher Lh Huang, William H Colledge, Andrew A Grace, Isabelle Baró, Flavien Charpentier
Loss-of-function mutations in SCN5A, the gene encoding Nav1.5 channel, have been associated with inherited progressive cardiac conduction disease (PCCD). We have proposed that Scn5a heterozygous knock-out (Scn5a+/-) mice, which are characterized by ventricular fibrotic remodeling with ageing, represent a model for PCCD. Our objectives were to identify the molecular pathway involved in fibrosis development and prevent its activation. Methods and results: Our study shows that myocardial interstitial fibrosis occurred in Scn5a+/- mice only after 45 weeks of age...
February 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28339390/stability-of-fentanyl-citrate-in-polyolefin-bags
#12
Ronald F Donnelly
Fentanyl is used to manage pain because it is a potent lipophilic opiate agonist. The stability of fentanyl in polyolefin bags when diluted to either 10 µg/mL or 50 µg/mL with sodium chloride 0.9% has not been studied. The chemical stability of fentanyl 50 µg/mL packaged in polyvinyl chloride bags has been studied, however, the stability in polyolefin bags is lacking. Polyolefin bags were aseptically filled with either 10-µg/mL or 50-µg/mL fentanyl solution. Containers were then stored at either 5°C and protected from light or 22°C and exposed to light for 93 days...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339379/stability-of-sodium-nitroprusside-in-5-dextrose-stored-at-4%C3%A2-c-in-polypropylene-syringes-protected-from-light
#13
Collin R Anderson, Deborah Collins, Trevor Laursen, Trevor Arave, Michael Helm
Sodium nitroprusside is a potent vasodilator employed intraoperatively and within critical care areas. The photolabile pharmaceutical agent has been used for decades and various stability studies have been executed. Due to potential shortages and the desire to batch compound sodium nitroprusside at a concentration of 1 mg/mL in polypropylene syringes, a new stability study was performed. Chromatographic analysis was conducted on a C18 column, with elution via an aqueous phase of 0.01 M sodium phosphate monobasic, adjusted to pH 6...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339172/maternal-high-fat-diet-consumption-enhances-offspring-susceptibility-to-dss-induced-colitis-in-mice
#14
Shima Bibi, Yifei Kang, Min Du, Mei-Jun Zhu
OBJECTIVE: Maternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis. METHODS: Dams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD...
March 24, 2017: Obesity
https://www.readbyqxmd.com/read/28339165/a-randomised-controlled-trial-of-sodium-citrate-spray-for-non-conductive-olfactory-disorders
#15
Carl Philpott, Sally Erskine, Allan Clark, Alexander Leeper, Mahmoud Salam, Rishi Sharma, George Murty, Thomas Hummel
BACKGROUND: Previous research has suggested that sodium citrate improves hyposmia by decreasing mucus calcium levels in the nose. This study aimed to confirm or refute this effect in a single application and assess potential side effects. METHODOLOGY: Study design was a randomised double-blind controlled trial of sodium citrate nasal spray (intervention) versus sterile water (control) in a tertiary care clinic. Fifty-five patients with non-conductive olfactory loss were randomised to receive the intervention or placebo...
March 24, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28339149/effect-of-food-intake-on-the-pharmacodynamics-of-tenapanor-a-phase-1-study
#16
Susanne A Johansson, Mikael Knutsson, Maria Leonsson-Zachrisson, David P Rosenbaum
Tenapanor (RDX5791/AZD1722) is a minimally systemic small-molecule inhibitor of the sodium/hydrogen exchanger NHE3. Tenapanor acts in the gut to reduce absorption of sodium and phosphate. This phase 1 open-label, 3-way crossover study (NCT02226783) evaluated the effect of food on the pharmacodynamics of tenapanor. Eighteen volunteers completed a randomized sequence of three 4-day treatments with tenapanor hydrochloride 15 mg twice daily: before food, after food, and while fasting. Participants received a diet standardized for sodium content...
March 24, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28339048/agr2-ameliorates-tumor-necrosis-factor-%C3%AE-induced-epithelial-barrier-dysfunction-via-suppression-of-nf-%C3%AE%C2%BAb-p65-mediated-mlck-p-mlc-pathway-activation
#17
Xiaolin Ye, Mei Sun
Intestinal epithelial barrier dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Anterior gradient protein 2 homologue (AGR2) assists in maintaining intestinal homeostasis in dextran sulphate sodium-induced mouse ileocolitis; however, it is unclear whether it modulates intestinal barrier function. Our study aimed to investigate the protective role of AGR2 in tumor necrosis factor (TNF)-α-induced intestinal epithelial barrier injury. Caco-2 cell monolayers were pre-transfected with an AGR2 plasmid and then exposed to TNF-α...
March 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28339010/effects-of-different-cellulose-membranes-regenerated-from-styela-clava-tunics-on-wound-healing
#18
Sung Hwa Song, Keum Yong Seong, Ji Eun Kim, Jun Go, Eun Kyoung Koh, Ji Eun Sung, Hong Joo Son, Young Jin Jung, Hye Sung Kim, Jin Tae Hong, Dae Youn Hwang
The aim of this study was to investigate the therapeutic effects of three different cellulose membranes (CMs) manufactured from Styela clava tunics (SCTs) on the healing of cutaneous wounds. We examined the physical properties and therapeutic effects of three CMs regenerated from SCTs (referred to as SCT‑ CMs), including normal CM (SCT‑CM), freeze-dried SCT‑CM (FSCT‑CM) and sodium alginate-supplemented SCT‑CM (ASCT‑CM) on skin regeneration and angiogenesis using Sprague-Dawley (SD) rats. FSCT‑CM exhibited an outstanding interlayered structure, a high tensile strength (1...
March 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28338828/validity-of-a-dietary-questionnaire-assessed-by-comparison-with-multiple-weighed-dietary-records-or-24-hour-recalls
#19
Changzheng Yuan, Donna Spiegelman, Eric B Rimm, Bernard A Rosner, Meir J Stampfer, Junaidah B Barnett, Jorge E Chavarro, Amy F Subar, Laura K Sampson, Walter C Willett
The authors evaluated the validity of a 152-item semiquantitative food frequency questionnaire (SFFQ) by comparing it with two 7-day dietary records (7DDRs) or up to 4 automated self-administered 24-hour recalls (ASA24s) over a 1-year period in the women's Lifestyle Validation Study (2010-2012), conducted among subgroups of the Nurses' Health Studies. Intakes of energy and 44 nutrients were assessed using the 3 methods among 632 US women. Compared with the 7DDRs, SFFQ responses tended to underestimate sodium intake but overestimate intakes of energy, macronutrients, and several nutrients in fruits and vegetables, such as carotenoids...
February 25, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28338762/redox-and-reactive-oxygen-species-network-in-acclimation-for-salinity-tolerance-in-sugar-beet
#20
M Sazzad Hossain, Abdelaleim Ismail ElSayed, Marten Moore, Karl-Josef Dietz
Fine-tuned and coordinated regulation of transport, metabolism and redox homeostasis allows plants to acclimate to osmotic and ionic stress caused by high salinity. Sugar beet is a highly salt tolerant crop plant and is therefore an interesting model to study sodium chloride (NaCl) acclimation in crops. Sugar beet plants were subjected to a final level of 300 mM NaCl for up to 14 d in hydroponics. Plants acclimated to NaCl stress by maintaining its growth rate and adjusting its cellular redox and reactive oxygen species (ROS) network...
February 18, 2017: Journal of Experimental Botany
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