BinShu Chai, Yong Wu, HengHui Yang, BiaoFeng Fan, SiYu Cao, XiaoFei Zhang, YaQing Xie, ZhiXiang Hu, ZhongLiang Ma, YunKui Zhang, Wei Pan, Wei Meng, Jiao Meng, WenJuan Tian, JiaLi Zhang, YanLi Li, Yang Shao, ShaoJia Wang
Intraperitoneal dissemination is the main method of epithelial ovarian cancer (EOC) metastasis, which is related to poor prognosis and a high recurrence rate. Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently closed loop structures that are implicated in the regulation of tumor development. In this study, hsa_circ_0001546 is downregulated in EOC primary and metastatic tissues vs. control tissues and this phenotype has a favorable effect on EOC OS and DFS. hsa_circ_0001546 can directly bind with 14-3-3 proteins to act as a chaperone molecule and has a limited positive effect on 14-3-3 protein stability...
April 18, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)