Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W Franks, Ana M Valdes, Tim D Spector, Gordan Lauc, Cristina Menni
BACKGROUND: A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the relationship between the N-glycome and postprandial metabolism and then explore the mediatory role of the plasma N-glycome in the relationship between postprandial lipaemia and T2DM. METHODS: We included 995 individuals from the ZOE-PREDICT 1 study with plasma N-glycans measured by ultra-performance liquid chromatography at fasting and triglyceride, insulin, and glucose levels measured at fasting and following a mixed-meal challenge...
July 3, 2023: BMC Medicine