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https://www.readbyqxmd.com/read/28222021/intense-blue-light-therapy-during-the-night-time-does-not-suppress-the-rhythmic-melatonin-biosynthesis-in-a-young-boy
#1
K Stebelova, J Kosnacova, M Zeman
OBJECTIVE: Melatonin is a hormone predominantly synthesized and secreted during the night by the pineal gland. Artificial light at night, especially its blue part, acutely suppresses the melatonin production. Th e aim of the present study was to find out, whether an intense blue light phototherapy of severe hyperbilirubinemia, may suppress the melatonin production during the night when the eyes will be properly protected by a sleep mask. METHODS: The main melatonin metabolite, 6-sulphatoxymelatonin was measured in urine in a nine-year old boy suffering from the Crigler-Najjar syndrome type I...
January 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28216852/a-simplified-approach-to-rehabilitate-an-ocular-defect-ocular-prosthesis
#2
Darshana Choubisa
A 42-year-old male patient complaint with missing right eye was referred to the Department of Prosthodontics and Crown and Bridge. This patient was seeking artificial eye replacement. On careful clinical examination, a defect with a shrunken orbit and intact tissue bed was found in the patient. As the patient was economically very poor, modified stock ocular prosthesis was advised. To rehabilitate this ocular defect, "single" appointment technique with clinically available material was adopted, which is discussed in the present communication...
January 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28207920/paper-based-microfluidic-system-for-tear-electrolyte-analysis
#3
Ali K Yetisen, Nan Jiang, Ali Tamayol, Guillermo U Ruiz-Esparza, Yu Shrike Zhang, Sofía Medina-Pando, Aditi Gupta, James S Wolffsohn, Haider Butt, Ali Khademhosseini, Seok-Hyun Yun
The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as dry eye disease, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to assessment of osmolarity or inflammatory markers and cannot differentiate between dry eye subclassifications. Here, we demonstrate a portable microfluidic system that allows quantitative analysis of electrolytes in the tear fluid that is suited for point-of-care settings...
February 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28197326/efficacy-of-carboxymethylcellulose-and-hyaluronate-in-dry-eye-disease-a-systematic-review-and-meta-analysis
#4
Jae Kyeong Song, Kiheon Lee, Hwa Yeon Park, Joon Young Hyon, Seung-Won Oh, Woo Kyung Bae, Jong-Soo Han, Se Young Jung, Yoo Jin Um, Ga-Hye Lee, Ji Hye Yang
BACKGROUND: The efficacy of two artificial tears, carboxymethylcellulose (CMC) and hyaluronate (HA), was compared in the treatment of patients with dry eye disease. METHODS: We conducted a systematic review and meta-analysis on randomized controlled trials in the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases. The efficacy was compared in terms of the mean change from baseline in tear break-up time. The meta-analysis was conducted using both random and fixed effect models...
January 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28181718/segmented-sleep-in-a-nonelectric-small-scale-agricultural-society-in-madagascar
#5
David R Samson, Melissa B Manus, Andrew D Krystal, Efe Fakir, James J Yu, Charles L Nunn
OBJECTIVES: We studied sleep in a rural population in Madagascar to (i) characterize sleep in an equatorial small-scale agricultural population without electricity, (ii) assess whether sleep is linked to noise levels in a dense population, and (iii) examine the effects of experimentally introduced artificial light on sleep timing. METHODS: Using actigraphy, sleep-wake patterns were analyzed for both daytime napping and nighttime wakefulness in 21 participants for a sum total of 292 days...
February 9, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28179165/selective-tms-induced-modulation-of-functional-connectivity-correlates-with-changes-in-behavior
#6
Puiu F Balan, Annelies Gerits, Dante Mantini, Wim Vanduffel
Despite the increasing use of functional connectivity (FC) studies in fundamental and clinical research, the link between FC and behavior is still poorly understood. To test the hypothesis that artificial modulation of FC correlates with changes in behavior in a quantitative manner, we performed behavioral and resting state fMRI experiments in monkeys while perturbing, offline, the frontal eye fields (FEF) using unilateral continuous theta burst transcranial magnetic stimulation (FEF-cTBS). Stimulation of left and right FEF caused remarkably specific decreases in FC, which were symmetric for intra-hemispheric and asymmetric for inter-hemispheric FC...
February 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28163544/lifitegrast-a-novel-drug-for-treatment-of-dry-eye-disease
#7
Afroz Abidi, Pooja Shukla, Ali Ahmad
Dry eye disease (DED) is an inflammatory disorder of ocular surfaces leading to severe disability, especially in the elderly age group. The mainstay of therapy includes artificial tears, punctual plugs, topical anti-inflammatory agents, and corticosteroids. In the past few years, only cyclosporine-A emulsions have been added to the existing therapy, but it is discontinued by most patients as it causes burning sensation in the eye. Hence, progress in new research for a better therapeutic option led to the discovery of lymphocyte function-associated antigen intercellular adhesion molecule 1 antagonist, lifitegrast...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28157224/comparison-of-clinical-outcome-with-different-treatment-regimens-in-acute-adenoviral-keratoconjunctivitis
#8
L Asena, E Şıngar Özdemir, A Burcu, E Ercan, M Çolak, D D Altınörs
PurposeTo compare the clinical outcome with different treatment regimens in Acute Adenoviral Keratoconjunctivitis (AAK).MethodsThe records of 110 patients diagnosed as AAK in two tertiary eye care centers were evaluated retrospectively. The treatment regimen, follow-up duration, time until improvement of the symptoms, visual acuity, clinical findings, Schirmer's test and the Ocular Surface Disease Index (OSDI) score at the first day, first week and third week were recorded. The Kruskal-Wallis Test and Chi-square test were used for comparison of quantitative and categorical variables, respectively...
February 3, 2017: Eye
https://www.readbyqxmd.com/read/28155208/comparison-between-botulinum-toxin-a-injection-and-lacrimal-punctal-plugs-for-the-control-of-post-lasik-dry-eye-manifestations-a-prospective-study
#9
Sameh M Fouda, Hala K Mattout
INTRODUCTION: Laser in situ keratomelieusis (LASIK) is one of the commonest refractive procedures performed nowadays. The dry eye problem is nearly universal in all patients after LASIK and it can be so annoying that the post-operative patient satisfaction is sometimes precluded. Conventional treatment includes the use of artificial tears. Alternative methods such as punctal plugs and botulinum toxin injection can be used for the management of post-LASIK dry eye. The aim of this study is to compare botulinum toxin injection in the orbicularis muscle to lacrimal punctal plugs for the control of post-LASIK dry eye manifestations...
February 2, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28154360/health-impact-assessment-of-asian-dust-cross-border-air-pollutant-and-necessary-preventive-measure
#10
Kazunari Onishi
The health effects of Asian dust (mineral dust) originating from dry lands such as the Gobi Desert and Taklamakan Desert have recently been a concern. In addition to Asian dust, transboundary airborne microparticles that reach Japan include various types of aerosol, such as artificial air pollutants and smoke from combustion. They originate from densely populated areas and are transported along the same route as Asian dust. We analyzed environmental factors and subjective symptoms involving the respiratory organ, nose, eyes, and skin using a conventional equation for estimation, and found that symptoms with a significant risk of worsening varied according to the type of pollutants reaching Japan...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28139163/comparison-of-autologous-serum-versus-preservative-free-artificial-tear-in-patients-with-dry-eyes-due-to-systemic-isotretinoin-therapy
#11
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Enes Gökler
PURPOSE: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease. METHOD: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28133189/-eye-disorders-associated-with-s-1-chemotherapy-in-gastric-cancer-patients
#12
Chika Fujii, Yutaka Kimura, Yoichi Makari, Jota Mikami, Junya Fujita, Shunji Kamigaki, Hitoshi Hayashi, Yukiko Yanagishita, Yukako Yasui, Toshihiko Ishizaka
Eye disorders are one of the characteristic adverse events associated with S-1 chemotherapy. In this retrospective study, we investigated the frequency and outcome of eye disorders associated with S-1 chemotherapy in gastric cancer patients. This retrospective study included 75 advanced gastric cancer patients who received S-1 monotherapy between January 2014 and December 2015. We retrospectively evaluated the frequency, Grade, and treatment of eye disorders. Eye disorders were observed in 16 patients(21%)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130041/detecting-change-using-standard-global-perimetric-indices-in-glaucoma
#13
Stuart K Gardiner, Shaban Demirel
PURPOSE: Various global indices are available to summarize results from standard automated perimetry. This study asks which index can detect significant deterioration earliest, for a fixed specificity. DESIGN: Comparison of prognostic indices. METHODS: Two cohorts were tested. A test-retest cohort contained 5 reliable visual fields, within a short interval, from 45 eyes of 23 participants with glaucoma and/or likelihood of developing glaucoma...
January 24, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28128068/mistletoe-and-garlic-extracts-as-polyurethane-carriers-a-possible-remedy-for-choroidal-melanoma
#14
Melania F Munteanu, Aurel Ardelean, Florin Borcan, Svetlana I Trifunschi, Ramona Gligor, Simona A Ardelean, Dorina Coricovac, Iulia Pinzaru, Florina Andrica, Livia-Cristina Borcan
Melanoma is known as the most dangerous form of skin cancer; whereas the malignant choroidal melanoma is an orphan disease known as the most common primary intraocular malignancy in adults. Literature suggests that the consumption of garlic and/or mistletoe leads to a reduced risk of developing cancer. The obtained microstructures present sizes between 1.05 and 2.60 μm and Zeta potentials between -7 and +36 mV. A good encapsulation was observed on different evaluations (88-92%). It was determined that approx...
January 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28125856/effect-of-topical-cyclopentolate-on-post-operative-pain-after-pterygium-surgery
#15
Sertan Goktas, Yasar Sakarya, Muammer Ozcimen, Rabia Sakarya, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan
OBJECTIVES: The aim was to evaluate the effectiveness of topical cyclopentolate following pterygium surgery for post-operative ocular pain. METHODS: All participants had nasal pterygium and underwent pterygium excision and conjunctival autografting with fibrin glue. Participants were randomised into two groups. Participants in group 1 received one per cent cyclopentolate eye drops and artificial tears upon completing surgery and were prescribed self-administered drops three times daily for three days, while participants in group 2 received a control (artificial tears) in a manner identical to group 1...
January 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28114567/retinotopic-to-spatiotopic-mapping-in-blind-patients-implanted-with-the-argus-ii-retinal-prosthesis
#16
Avi Caspi, Arup Roy, Jessy D Dorn, Robert J Greenberg
Purpose: To quantify the precision of mapping from retinotopic (retina-centered) to spatiotopic (world-centered) coordinates in blind humans implanted with a retinal prosthesis device. Additionally, to demonstrate that an eye tracker can be calibrated on sightless patients based on the percept from a visual implant. Methods: We directly activated epiretinal electrodes to create retinotopic stimuli and recorded the location of the percept at world-based coordinates...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28114483/bayesian-microsaccade-detection
#17
Andra Mihali, Bas van Opheusden, Wei Ji Ma
Microsaccades are high-velocity fixational eye movements, with special roles in perception and cognition. The default microsaccade detection method is to determine when the smoothed eye velocity exceeds a threshold. We have developed a new method, Bayesian microsaccade detection (BMD), which performs inference based on a simple statistical model of eye positions. In this model, a hidden state variable changes between drift and microsaccade states at random times. The eye position is a biased random walk with different velocity distributions for each state...
January 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#18
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28105741/potential-use-of-cubic-phase-masks-for-extending-the-range-of-clear-vision-in-presbyopes-initial-calculation-and-simulation-studies
#19
Justo Arines, Citlalli Almaguer, Eva Acosta
PURPOSE: In this paper we analyse the potential use of a non-symmetrical optical element, a cubic phase mask, for extending the range of clear vision of presbyopic eyes. Additionally, we will discuss the appropriateness of the visual Strehl ratio to analyse this sort of presbyopic solution based on non-symmetrical phase masks contrasted with through-focus retinal images. METHODS: In order to evaluate the performance of the cubic phase mask we employed computational Fourier Optics to compute the different visual Strehl criteria as well as simulate the retinal images...
January 20, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28103978/-cosmetological-thinking-and-methods-in-tcm-in-the-sui-tang-dynasty
#20
Y J Wu
In the heyday of Chinese feudal society, women's status in the society of the Sui-Tang period was improved in the Tang Dynasty.The demand for female to stay young and anti-aging had attracted lots of attention in the society, thus providing a favorable social environment for the formation and development of Chinese herbal cosmetology. The important representative medical works on traditional Chinese medicine (TCM) were published in the Sui and Tang Dynasties, such as Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold), Qian jin yi fang (Supplement to Recipes Worth A Thousand Gold), Wai tai mi yao (Arcane Essentials from the Imperial Library) etc...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
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