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https://www.readbyqxmd.com/read/28805371/wavelength-resolved-photon-fluxes-of-indoor-light-sources-implications-for-hox-production
#1
Shawn Finley Kowal, Seth Robert Allen, Tara F Kahan
Photochemistry is a largely-unconsidered potential source of reactive species such as hydroxyl and peroxy radicals (OH and HO2, "HOx") indoors. We present measured wavelength-resolved photon fluxes and distance dependences of indoor light sources including halogen, incandescent, and compact fluorescent lights (CFL) commonly used in residential buildings; fluorescent tubes common in industrial and commercial settings; and sunlight entering buildings through windows. We use these measurements to predict indoor HOx production rates from the photolysis of nitrous acid (HONO), hydrogen peroxide (H2O2), ozone (O3), formaldehyde (HCHO) and acetaldehyde (CH3CHO)...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28804726/low-dose-of-lipopolysaccharide-pretreatment-preventing-subsequent-endotoxin-induced-uveitis-is-associated-with-pi3k-akt-pathway
#2
Nan Zhang, Shuo Yu, Xinli Liu, Hong Lu
PURPOSE: To explore the effects of LPS pretreatment on endotoxin-induced uveitis and PI3K/AKT pathway. METHODS: Endotoxin-induced uveitis was induced by a single subcutaneous injection of 200 μg LPS. For the endotoxin tolerance group, induction of EIU was preceded by daily subcutaneous injection of 0.1 mg/kg LPS for five days. Clinical scores were graded at 24 h after EIU under a slit lamp microscope. HE stain was performed to observe the histopathology. Aqueous humor TNF-α concentration was quantified with enzyme-linked immunosorbent assay...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28803792/rapid-and-visual-detection-of-leptospira-in-urine-by-ligb-lamp-assay-with-pre-addition-of-dye
#3
Syed Atif Ali, Gurpreet Kaur, Nongthombam Boby, T Sabarinath, Khushal Solanki, Dheeraj Pal, Pallab Chaudhuri
Leptospirosis is considered to be the most widespread zoonotic disease caused by pathogenic species of Leptospira. The present study reports a novel set of primers targeting LigB gene for visual detection of pathogenic Leptospira in urine samples through Loop-mediated isothermal amplification (LAMP). The results were recorded by using Hydroxyl napthol blue (HNB), SYBR GREEN I and calcein. Analytical sensitivity of LAMP was as few as 10 leptospiral organisms in spiked urine samples from cattle and dog. LigB gene based LAMP, termed as LigB-LAMP, was found 10 times more sensitive than conventional PCR...
August 10, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28803767/semantic-control-deficits-impair-understanding-of-thematic-relationships-more-than-object-identity
#4
Hannah Thompson, James Davey, Paul Hoffman, Glyn Hallam, Rebecca Kosinski, Sarah Howkins, Emma Wooffindin, Rebecca Gabbitas, Elizabeth Jefferies
Recent work has suggested a potential link between the neurocognitive mechanisms supporting the retrieval of events and thematic associations (i.e., knowledge about how concepts relate in a meaningful context) and semantic control processes that support the capacity to shape retrieval to suit the circumstances. Thematic associations and events are inherently flexible: the meaning of an item changes depending on the context (for example, lamp goes with reading, bicycle and police). Control processes might stabilise weak yet currently-relevant interpretations during event understanding...
August 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28803416/rapid-screening-method-for-male-dna-by-using-the-loop-mediated-isothermal-amplification-assay
#5
Masashi Kitamura, Seiji Kubo, Jin Tanaka, Tatsushi Adachi
Screening for male-derived biological material from collected samples plays an important role in criminal investigations, especially those involving sexual assaults. We have developed a loop-mediated isothermal amplification (LAMP) assay targeting multi-repeat sequences of the Y chromosome for detecting male DNA. Successful amplification occurred with 0.5 ng of male DNA under isothermal conditions of 61 to 67 °C, but no amplification occurred with up to 10 ng of female DNA. Under the optimized conditions, the LAMP reaction initiated amplification within 10 min and amplified for 20 min...
August 12, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28801769/illusory-limb-movements-activate-different-brain-networks-than-imposed-limb-movements-an-ale-meta-analysis
#6
Jeffrey M Kenzie, Ettie Ben-Shabat, Gemma Lamp, Sean P Dukelow, Leeanne M Carey
Proprioceptive information allows us to perform smooth coordinated movements by constantly updating us with knowledge of the position of our limbs in space. How this information is combined and processed to form conscious perceptions of limb position is still relatively unknown. Several functional neuroimaging studies have attempted to tease out the brain areas responsible for proprioceptive processing in the human brain. Yet there still exists some disagreement in the specific brain regions involved. In order to consolidate the current knowledge in the field, we performed a systematic review of the literature and an activation likelihood estimation (ALE) meta-analysis of functional neuroimaging studies of proprioception...
August 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28801092/anterior-segment-optical-coherence-tomography-for-the-diagnosis-of-corneal-dystrophies-according-to-the-ic3d-classification
#7
REVIEW
Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M Heindl
Corneal dystrophies are categorized according to the International Committee for Classification of Corneal Dystrophies (IC3D) classification, and their treatment depends on the affected structures and layer of the cornea. Therefore, estimating the depth and extent of the morphological changes due to the specific dystrophy is crucial when deciding between different treatment options. Besides superficial laser treatments and penetrating keratoplasty, minimal invasive lamellar keratoplasties such as Descemet membrane endothelial keratoplasty), deep anterior lamellar keratoplasty, or Descemet stripping automated keratoplasty have become increasingly popular to exchange the specific opaque layers in dystrophic eyes...
August 8, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28799235/dipeptidyl-peptidase-4-serum-activity-and-concentration-are-increased-in-women-with-polycystic-ovary-syndrome
#8
Sindy Blauschmidt, Thomas Greither, Katharina Lampe, Solveig Köller, Petra Kaltwaßer, Hermann M Behre
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a complex disease, the etiology of which is not well understood. Alterations in potential candidate genes involved in the biosynthesis and metabolism of androgens, folliculogenesis, and insulin and glucose metabolism have been suggested as possible etiologies. Dipeptidyl peptidase-4 (DPP4) plays a key role in glucose homeostasis and, thus, in the regulation of insulin secretion. The aim of our study was to analyze the DPP4 activity and concentrations in the serum of PCOS and non-PCOS patients and, additionally, study the activation of the DPP4 promoter by androgens in vitro...
August 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28799192/wood-s-lamp-for-vitiligo-disease-stability-and-early-recognition-of-initiative-pigmentation-after-epidermal-grafting
#9
Yen-Jen Wang, Chang-Cheng Chang, Kun-Lin Cheng
The prerequisite for a successful vitiligo epidermal grafting surgery is the stable status of the disease. We used Wood's lamp to assess vitiligo activity to determine the disease stability, surgical grafting timing and the early recognition of re-pigmentation after grafting. Amelanotic lesions with sharply demarcated borders are typically stable and are good candidates for grafting. The re-pigmentation was first recognised under Wood's lamp as hypochromic islands, which progressed to normally pigmented islands...
August 10, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28798845/vancomycin-resistant-gene-identification-from-live-bacteria-on-an-integrated-microfluidic-system-by-using-low-temperature-lysis-and-loop-mediated-isothermal-amplification
#10
Wen-Hsin Chang, Ju-Ching Yu, Sung-Yi Yang, Yi-Cheng Lin, Chih-Hung Wang, Huey-Ling You, Jiunn-Jong Wu, Mel S Lee, Gwo-Bin Lee
Vancomycin-resistant Enterococcus (VRE) is a kind of enterococci, which shows resistance toward antibiotics. It may last for a long period of time and meanwhile transmit the vancomycin-resistant gene (vanA) to other bacteria. In the United States alone, the resistant rate of Enterococcus to vancomycin increased from a mere 0.3% to a whopping 40% in the past two decades. Therefore, timely diagnosis and control of VRE is of great need so that clinicians can prevent patients from becoming infected. Nowadays, VRE is diagnosed by antibiotic susceptibility test or molecular diagnosis assays such as matrix-assisted laser desorption ionization/time-of-flight mass spectrometry and polymerase chain reaction...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28796820/identification-of-plasmodium-spp-in-neotropical-primates-of-maranhense-amazon-in-northeast-brazil
#11
Mayra Araguaia Pereira Figueiredo, Silvia Maria Di Santi, Wilson Gómez Manrique, Marcos Rogério André, Rosangela Zacarias Machado
In the Brazilian Amazon region, malaria caused by Plasmodium malariae is considered to be a zoonosis because of cross-transfer of the parasite between humans and Neotropical primates. To contribute information on this issue, we investigated occurrences of natural infection with Plasmodium sp. among Neotropical primates in the Maranhense Amazon (Amazon region of the state of Maranhão), in the northeastern region of Brazil. Blood samples were collected from 161 Neotropical primates of six species that were caught in an environmental reserve (Sítio Aguahy) and from captive primates (CETAS-Wildlife Screening Center, municipality of São Luís), in Maranhão...
2017: PloS One
https://www.readbyqxmd.com/read/28794900/structure-versus-function-correlation-between-outer-retinal-and-choroidal-thicknesses-measured-by-swept-source-oct-with-multifocal-electroretinography-and-visual-acuity
#12
Ignacio Flores-Moreno, Luis Arias-Barquet, Marcos J Rubio-Caso, Alex Muñoz-Blanco, María Vidal-Martí, Jaume Catala-Mora, José M Ruiz-Moreno, Jay S Duker, Josep M Caminal
BACKGROUND: To correlate retina-choroidal anatomy as assessed via swept-source OCT (SS-OCT) with retinal function as determined by best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG). METHODS: Thirty-three eyes from 33 patients including 16 with neovascular AMD (nvAMD) and 17 controls were included. Patients were included in the present study after a complete ophthalmologic examination, including BCVA, slit-lamp study, intraocular pressure measurement, dilated fundus examination after tropicamide instillation, SD-OCT, SS-OCT, fundus photographs and mfERG...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28794613/association-of-fluorescein-anterior-corneal-mosaic-and-corneal-k-structures-by-in-vivo-laser-confocal-microscopy-in-patients-with-keratoconus
#13
Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama
OBJECTIVE: To report the in vivo laser confocal microscopy findings of corneas with keratoconus, with special attention to abnormality of Bowman's layer and sub-Bowman's fibrous structures (Kobayashi-structures [K-structures]). METHODS: Sixteen keratoconic eyes in 8 consecutive patients with keratoconus (4 males, 4 females, mean age, 41.1 years) were included in this study. Slit-lamp biomicroscopic photos were taken with or without fluorescein staining. The existence of anterior corneal mosaic (ACM) after eyelid rubbing under fluorescein staining was documented...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28794239/cursed-lamp-the-problem-of-spontaneous-abortion
#14
William Simkulet
Many people believe human fetuses have the same moral status as adult human persons, that it is wrong to allow harm to befall things with this moral status, and thus voluntary, induced abortion is seriously morally wrong. Recently, many prochoice theorists have argued that this antiabortion stance is inconsistent; approximately 60% of human fetuses die from spontaneous abortion, far more than die from induced abortion, so if antiabortion theorists really believe that human fetuses have significant moral status, they have strong moral obligations to oppose spontaneous abortion...
August 9, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28793018/prevalence-of-hepatitis-b-and-c-virus-infection-among-alcoholic-individuals-importance-of-screening-and-vaccination
#15
Vanessa Faria Cortes, Angela Taveira, Helena Medina Cruz, Amanda Alves Reis, Jéssica Silva Cezar, Brener Santos Silva, Cintia Feliciano D'Assunção, Elisabeth Lampe, Livia Melo Villar
Drug users have been reported to have an increased risk for acquisition of viral hepatitis. This study aims to evaluate the prevalence of HBV and HCV infection and usefulness of saliva for HBsAg and anti-HCV detection in alcoholic patients.A total of 90 alcoholic patients were recruited in 2013. HBsAg and anti-HCV were tested in serum and saliva, anti-HBc and anti-HBs were tested in serum using commercial enzyme immunoassays (EIA).Using serum samples, anti-HCV, HBsAg, anti-HBc and anti-HBs prevalences were 5...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28791410/bestrophin-1-gene-analysis-and-associated-clinical-findings-in-a-chinese-patient-with-best-vitelliform-macular-dystrophy
#16
Ying Lin, Tao Li, Hongbin Gao, Yu Lian, Chuan Chen, Yi Zhu, Yonghao Li, Bingqian Liu, Wenli Zhou, Hongye Jiang, Xialin Liu, Xiujuan Zhao, Xiaoling Liang, Chenjin Jin, Xinhua Huang, Lin Lu
The aim of the present study was to investigate the clinical characteristics and the underlying genetic causes of Best vitelliform macular dystrophy (BVMD) in a sporadic case in a Chinese patient. A 10‑year‑old boy was diagnosed with BVMD; complete ophthalmic examinations were performed, including best‑corrected visual acuity, intraocular pressure, slit‑lamp examination, fundus photograph, optical coherence tomography and fundus fluorescein angiography imaging. Genomic DNA was extracted from leukocytes of the peripheral blood collected from this patient and his family members...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28789979/conjunctival-subepithelial-fibrosis-and-meibomian-gland-atrophy-in-ocular-graft-versus-host-disease
#17
Yael Kusne, M'hamed Temkit, Nandita Khera, Dharmendra R Patel, Joanne F Shen
PURPOSE: Dry eye symptoms greatly impact patients' quality of life in ocular graft-versus-host disease (oGVHD). Various ocular surface changes have been reported in oGVHD, including meibomian gland atrophy (MGA) and clinical conjunctival scarring or subepithelial fibrosis (CSEF). The relationships between CSEF, MGA, and other ocular surface changes in oGVHD were examined. METHODS: Charts of 21 consecutive GVHD patients examined by a single ophthalmologist were retrospectively reviewed...
August 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28789808/visible-light-driven-n-tio2-sio2-fe3o4-magnetic-nanophotocatalysts-synthesis-characterization-and-photocatalytic-degradation-of-ppcps
#18
Ashutosh Kumar, Musharib Khan, Liping Fang, Irene M C Lo
TiO2-based photocatalysis offers certain advantages like rapid degradation and mineralization of organic compounds. However, the practical applicability of photocatalysts in degradation of pharmaceuticals and personal care products (PPCPs) is still restricted by challenges including their limited photocatalytic activity under visible light and difficulty in their separation from suspension. To overcome these challenges, a visible-light-driven magnetic N-TiO2@SiO2@Fe3O4 nanophotocatalyst was developed through fine-tuning the pertinent factors (calcination temperature, Fe3O4 loading, and nitrogen doping) involved during synthesis process, on the basis of degradation of ibuprofen (a typical PPCP)...
July 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28782578/performance-of-rapid-diagnostic-tests-for-detection-of-hepatitis-b-and-c-markers-in-hiv-infected-patients
#19
Jakeline Ribeiro Barbosa, Jeová Keny Baima Colares, Geane Lopes Flores, Vanessa Faria Cortes, Juliana Custódio Miguel, Moyra Machado Portilho, Vanessa Alves Marques, Denise Vigo Potsch, Carlos Eduardo Brandão-Mello, Marcia Amendola-Pires, José Henrique Pilotto, Danielle Malta Lima, Elisabeth Lampe, Livia Melo Villar
There is little information describing the influence of HIV infection upon the performance of rapid diagnostic tests (RDTs) for hepatitis B and C virus diagnosis. This study aims to evaluate the performance of RDTs for HBsAg and anti-HCV detection among HIV-infected individuals. A total of 362 HIV infected individuals were recruited from clinics between January 2013 to November 2014 in the southeast and northeast of Brazil. HBsAg and anti-HCV were detected using commercial EIAs and four RDTs: HBV (Vikia HBsAg(®) and Wama Imuno-Rapido HBV(®)) and HCV (Bioeasy Teste Rápido HCV(®) and Wama Imuno-Rapido HCV(®))...
August 4, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28781128/six-cases-of-sporadic-schwannomatosis-topographic-distribution-and-outcomes-of-peripheral-nerve-tumors
#20
G Chick, J Victor, N Hollevoet
The diagnosis of schwannomatosis is often overestimated and is based on the existence of multiple peripheral nerve tumors composed exclusively of schwannomas, in the absence of clinical signs of neurofibromatosis type 2 (NF2). Sporadic forms are much more frequent than familial forms. The objective of this study was to describe the distribution of peripheral nerve tumors and investigate the outcomes of schwannomas in the context of sporadic schwannomatosis. We conducted a retrospective study of patients who fulfilled clinical diagnostic criteria for sporadic schwannomatosis...
August 3, 2017: Hand Surgery and Rehabilitation
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