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https://www.readbyqxmd.com/read/28528012/impact-of-total-pars-plana-vitrectomy-on-postoperative-complications-in-aphakic-snap-on-type-1-boston-keratoprosthesis
#1
Victor L Perez, Ella H Leung, Audina M Berrocal, Thomas A Albini, Jean Marie Parel, Guillermo Amescua, Eduardo C Alfonso, Tayyeba K Ali, Allister Gibbons
PURPOSE: To determine the impact of total pars plana vitrectomies (PPVs) with peripheral shaving of the vitreous base on the rates of postoperative complications in patients with aphakic, snap-on type I Boston keratoprostheses (KPros). DESIGN: Retrospective, consecutive case series. PARTICIPANTS: A total of 48 eyes in 46 patients with implantation of aphakic, snap-on type 1 Boston KPros performed at a tertiary care facility between January 1, 2007, and December 31, 2013, were included...
May 17, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28527841/a-comparison-of-2-and-3-dimensional-healing-assessment-after-endodontic-surgery-using-cone-beam-computed-tomographic-volumes-or-periapical-radiographs
#2
Tom Schloss, David Sonntag, Meetu R Kohli, Frank C Setzer
INTRODUCTION: The aim of this study was to compare the assessment of healing after endodontic microsurgery using 2-dimensional (2D) periapical films versus 3-dimensional (3D) cone-beam computed tomographic (CBCT) imaging. METHODS: The healing of 51 teeth from 44 patients was evaluated using Molven's criteria (2D) and modified PENN 3D criteria. The absolute area (2D) and volume (3D) changes of apical lesions preoperatively and at follow-up were calculated by segmentation using OsiriX software (Pixmeo, Bernex, Switzerland) and ITK-Snap (free software)...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28526093/canine-infection-with-borrelia-burgdorferi-dirofilaria-immitis-anaplasma-spp-and-ehrlichia-spp-in-canada-2013-2014
#3
Brian H Herrin, Andrew S Peregrine, Jonas Goring, Melissa J Beall, Susan E Little
BACKGROUND: Canine test results generated by veterinarians throughout Canada from 2013-2014 were evaluated to assess the geographical distribution of canine infection with Borrelia burgdorferi, Dirofilaria immitis, Ehrlichia spp., and Anaplasma spp. METHODS: The percent positive test results of 115,636 SNAP® 4Dx® Plus tests from dogs tested were collated by province and municipality to determine the distribution of these vector-borne infections in Canada. RESULTS: A total of 2,844/115,636 (2...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28523033/low-energy-versus-middle-energy-extracorporeal-shockwave-therapy-for-the-treatment-of-snapping-scapula-bursitis
#4
Nihat Acar
OBJECTIVE: Extracorporeal shockwave therapy (ESWT) has been used successfully in treatment of musculoskeletal disorders. Our objective was to assess the effectiveness of low versus middle-energy ESWT on snapping scapula bursitis. METHODS: Thirty-five patients, divided into two groups, group (L), received low-energy ESWT, group (M) received middle-energy ESWT. Groups were evaluated at 1,3,6 and 12 months using the Visual Analogue Scale (VAS), the Constant-Murley scoring (CMS) and the Roles and Maudsley criteria...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521781/telling-our-stories-heroin-assisted-treatment-and-snap-activism-in-the-downtown-eastside-of-vancouver
#5
Susan Boyd, Dave Murray, Donald MacPherson
BACKGROUND: This article highlights the experiences of a peer-run group, SALOME/NAOMI Association of Patients (SNAP), that meets weekly in the Downtown Eastside of Vancouver, British Columbia, Canada. SNAP is a unique independent peer- run drug user group that formed in 2011 following Canada's first heroin-assisted treatment trial (HAT), North America Opiate Medication Initiative (NAOMI). SNAP's members are now made up of former research participants who participated in two heroin-assisted trials in Vancouver...
May 18, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28521269/a-new-technique-for-dorsal-sural-nerve-conduction-study-with-surface-strip-electrodes
#6
Shoji Hemmi, Katsumi Kurokawa, Taiji Nagai, Ryutaro Kushida, Toshio Okamoto, Tatsufumi Murakami, Yoshihide Sunada
OBJECTIVE: To obtain higher amplitude of dorsal sural sensory nerve action potentials (SNAPs), we used a new method for dorsal sural nerve conduction study with surface strip electrodes (SSEs). METHODS: Dorsal sural SNAPs were recorded orthodromically. The recording electrodes were placed behind the lateral malleolus. SSEs were attached to the laterodorsal aspect of the foot for stimulation of the dorsal sural nerve (DSN). We also used a conventional method with a standard bipolar stimulator and compared the findings...
April 19, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28520562/reliability-and-repeatability-of-pulp-volume-reconstruction-through-three-different-volume-calculations
#7
T Y Marroquin Penaloza, S Karkhanis, S I Kvaal, S Vasudavan, E Castelblanco, E Kruger, M Tennant
OBJECTIVE: To test the variability of the volume measurements when different segmentation methods are applied in pulp volume reconstruction. MATERIALS AND METHODS: Osirix® and ITK-SNAP software were used. Different segmentation methods (Part A) and volume approaches (Part B) were tested in a sample of 21 dental CBCT's from upper canines. Different combinations of the data set were also tested on one lower molar and one upper canine (Part C) to determine the variability of the results when automatic segmentation is performed...
December 1, 2016: Journal of Forensic Odonto-stomatology
https://www.readbyqxmd.com/read/28518176/seasonal-variations-in-cardiovascular-disease
#8
REVIEW
Simon Stewart, Ashley K Keates, Adele Redfern, John J V McMurray
Cardiovascular disease (CVD) follows a seasonal pattern in many populations. Broadly defined winter peaks and clusters of all subtypes of CVD after 'cold snaps' are consistently described, with corollary peaks linked to heat waves. Individuals living in milder climates might be more vulnerable to seasonality. Although seasonal variation in CVD is largely driven by predictable changes in weather conditions, a complex interaction between ambient environmental conditions and the individual is evident. Behavioural and physiological responses to seasonal change modulate susceptibility to cardiovascular seasonality...
May 18, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28515322/g%C3%AE-%C3%AE-directly-modulates-vesicle-fusion-by-competing-with-synaptotagmin-for-binding-to-neuronal-snare-proteins-embedded-in-membranes
#9
Zack Zurawski, Brian Page, Michael C Chicka, Rebecca L Brindley, Christopher A Wells, Anita M Preininger, Karren Hyde, James A Gilbert, Osvaldo Cruz-Rodriguez, Kevin P M Currie, Edwin R Chapman, Simon Alford, Heidi E Hamm
Gi/o-coupled GPCRs can inhibit neurotransmitter release at synapses via multiple mechanisms. In addition to Gβγ-mediated modulation of voltage-gated calcium channels(VGCC), inhibition can also be mediated through the direct interaction of Gβγ subunits with the soluble N-ethylmaleimide attachment protein receptor (SNARE) complex of the vesicle fusion apparatus. Binding studies with soluble SNARE complexes have shown that Gβγ binds to both ternary SNARE complexes, t-SNARE heterodimers, and monomeric SNAREs, competing with synaptotagmin(syt)1 for binding sites on t-SNARE...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28513638/automatic-assignment-of-metal-containing-peptides-in-proteomic-lc-ms-and-ms-ms-data-sets
#10
Christopher A Wootton, Yuko P Y Lam, Matthew Willetts, Maria A van Agthoven, Mark P Barrow, Peter J Sadler, Peter B O Connor
Transition metal-containing proteins and enzymes are critical for the maintenance of cellular function and metal-based (metallo)drugs are commonly used for the treatment of many diseases, such as cancer. Detection and characterisation of metallodrug targets is crucial for improving drug-design and therapeutic efficacy. Due to the unique isotopic ratios of many metal species, and the complexity of proteomic samples, standard MS data analysis of these species is unsuitable for accurate assignment. Herein a new method for differentiating metal-containing species within complex LCMS data is presented based upon the Smart Numerical Annotation Procedure (SNAP)...
May 17, 2017: Analyst
https://www.readbyqxmd.com/read/28512748/genetic-influences-on-adhd-symptom-dimensions-examination-of-a-priori-candidates-gene-based-tests-genome-wide-variation-and-snp-heritability
#11
L Cinnamon Bidwell, Joshua C Gray, Jessica Weafer, Abraham A Palmer, Harriet de Wit, James MacKillop
Although the heritability of ADHD is estimated to be high, identifying specific genetic markers remains challenging. Most studies to date have examined the genetic basis of ADHD by employing dichotomous diagnostic phenotypes, but, as ADHD symptoms tend to be phenotypically dimensional, an alternative and potentially informative approach is to examine continuous indices of inattention and hyperactivity-impulsivity symptoms. The current study aimed to identify genetic effects on dimensionally-focused adult ADHD-related phenotypes in 990 individuals of European ancestry with intentionally low levels of substance misuse to avoid confounding...
June 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28512127/a-structure-derived-snap-trap-mechanism-of-a-multispecific-serpin-from-the-dysbiotic-human-oral-microbiome
#12
Theodoros Goulas, Miroslaw Ksiazek, Irene Garcia-Ferrer, Alicja M Sochaj-Gregorczyk, Irena Waligorska, Marcin Wasylewski, Jan Potempa, F Xavier Gomis-Rüth
Enduring host-microbiome relationships are based on adaptive strategies within a particular ecological niche. Tannerella forsythia is a dysbiotic member of the human oral microbiome that inhabits periodontal pockets and contributes to chronic periodontitis. To counteract endopeptidases from the host or microbial competitors, T. forsythia possesses a serpin-type proteinase inhibitor called miropin. While serpins from animals, plants, and viruses have been widely studied, those from prokaryotes have received only limited attention...
May 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28510347/bioluminescent-antibodies-for-point-of-care-diagnostics
#13
Lin Xue, Qiuliyang Yu, Rudolf Griss, Alberto Schena, Kai Johnsson
We introduce a general method to transform antibodies into ratiometric, bioluminescent sensor proteins for the no-wash quantification of analytes. Our approach is based on the genetic fusion of antibody fragments to NanoLuc luciferase and SNAP-tag, the latter being labeled with a synthetic fluorescent competitor of the antigen. Binding of the antigen, here synthetic drugs, by the sensor displaces the tethered fluorescent competitor from the antibody and disrupts bioluminescent resonance energy transfer (BRET) between the luciferase and fluorophore...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28507976/painful-pseudowinging-and-snapping-of-scapula-due-to-subscapular-osteochondroma-a-case-report
#14
Raja Rameez, Mehmood Ul-Hassan, Hilal A Kotwal, Khursheed A H Kangoo, Asif Nazir
INTRODUCTION: Osteochondroma or exostosis is most common benign bone tumors. They are usually seen in the metaphyses of long bones with more than 35% of cases affecting the bone around the knee and are seldom found in flat bones like scapula. When present in scapula, they may cause abnormal scapulothoracic movements leading to pain, snapping, and pseudowinging of scapula. CASE REPORT: We describe a novel case of osteochondroma arising on the ventral aspect of right scapula in a 16-year-old otherwise healthy female patient causing snapping and pseudowinging of scapula and occasional pain in affected area...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28506234/anti-malarial-medicine-quality-field-studies-and-surveys-a-systematic-review-of-screening-technologies-used-and-reporting-of-findings
#15
REVIEW
Mirza Lalani, Freddy Eric Kitutu, Siân E Clarke, Harparkash Kaur
BACKGROUND: Assessing the quality of medicines in low-middle income countries (LMICs) relies primarily on human inspection and screening technologies, where available. Field studies and surveys have frequently utilized screening tests to analyse medicines sampled at the point of care, such as health care facilities and medicine outlets, to provide a snap shot of medicine quality in a specific geographical area. This review presents an overview of the screening tests typically employed in surveys to assess anti-malarial medicine quality, summarizes the analytical methods used, how findings have been reported and proposes a reporting template for future studies...
May 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28506169/painful-snapping-of-thumb-caused-by-osteochondroma-of-trapezium
#16
Navapong Anantavorasakul, Chairoj Uerpairojkit, Somsak Leechavengvongs
Osteochondroma is the most common benign bone tumor. Lesions occurring at the carpal bones are extremely rare. There are very few cases of osteochondroma at the trapezium had been reported in the English literature. We reported a 47-year-old patient with an osteochondroma of the left trapezium presented with painful snapping of abductor pollicis longus tendon.
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28505977/hippocampal-and-clinical-trajectories-of-mild-cognitive-impairment-with-suspected-non-alzheimer-s-disease-pathology
#17
Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Fernando Caravaggio, Yusuke Iwata, Philip Gerretsen, Julia Kim, Hiroyoshi Takeuchi, Shunichiro Shinagawa, Raihaan Patel, M Mallar Chakravarty, Ariel Graff-Guerrero
Suspected non-Alzheimer's disease pathophysiology (SNAP) characterizes individuals showing neurodegeneration (e.g., hypometabolism) without amyloid-β (Aβ). Findings from previous studies regarding clinical and structural trajectories of SNAP are inconsistent. Using data from the Alzheimer's Disease Neuroimaging Initiative, patients with amnestic mild cognitive impairment (MCI) were categorized into four groups: amyloid positive with hypometabolism (Aβ+ND+), amyloid only (Aβ+ND-), neither amyloid nor hypometabolism (Aβ-ND-), and SNAP (Aβ-ND+)...
May 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28504571/the-legend-of-the-luschka-tubercle-and-its-association-with-snapping-scapulae-osseous-morphology-of-snapping-scapulae-on-ct-images
#18
Tobias J Dietrich, Christoph A Agten, Philipp Fürnstahl, Lazaros Vlachopoulos, Christian W A Pfirrmann
OBJECTIVE: The purpose of this article is to determine the osseous morphology of snapping scapulae on CT images. MATERIALS AND METHODS: Retrospectively, 2D and 3D CT images of the scapulae of 35 patients with snapping scapula were compared with 35 age-matched control group subjects. Two observers analyzed the following parameters: presence of the Luschka tubercle; abnormalities of the bones and periscapular soft tissues; shape, thickness, and length of the superior angle of the scapula; craniocaudal length of the scapula; minimum distance between the scapula and rib cage; depth of the subscapular fossa; and the superomedial angle...
May 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28501993/antibody-validation-by-western-blotting
#19
Michele Signore, Valeria Manganelli, Alex Hodge
Validation of antibodies is an integral part of translational research, particularly for biomarker discovery. Assaying the specificity of the reagent (antibody) and confirming the identity of the protein biomarker is of critical importance prior to implementing any biomarker in clinical studies, and the lack of such quality control tests may result in unexpected and/or misleading results.Antibody validation is the procedure in which a single antibody is thoroughly assayed for sensitivity and specificity. Although a plethora of commercial antibodies exist, antibody specificity must be extensively demonstrated using diverse complex biological samples, rather than purified recombinant proteins, prior to use in clinical translational research...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28501632/high-levels-of-maternally-transferred-mercury-disrupt-magnetic-responses-of-snapping-turtle-hatchlings-chelydra-serpentina
#20
Lukas Landler, Michael S Painter, Brittney Hopkins Coe, Paul W Youmans, William A Hopkins, John B Phillips
The Earth's magnetic field is involved in spatial behaviours ranging from long-distance migration to non-goal directed behaviours, such as spontaneous magnetic alignment (SMA). Mercury is a harmful pollutant most often generated from anthropogenic sources that can bio-accumulate in animal tissue over a lifetime. We compared SMA of hatchling snapping turtles from mothers captured at reference (i.e., low mercury) and mercury contaminated sites. Reference turtles showed radio frequency-dependent SMA along the north-south axis, consistent with previous studies of SMA, while turtles with high levels of maternally inherited mercury failed to show consistent magnetic alignment...
May 11, 2017: Environmental Pollution
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