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https://www.readbyqxmd.com/read/28715317/itk-snap-an-intractive-medical-image-segmentation-tool-to-meet-the-need-for-expert-guided-segmentation-of-complex-medical-images
#1
Paul A Yushkevich, Guido Gerig
Imaging is a crucial tool in medicine and biomedical research. Magnetic resonance imaging (MRI), computational tomography (CT), proton emission tomography (PET), and ultrasound are routinely used not only to diagnose disease but also to plan and guide surgical interventions, track disease progression, measure the response of the body to treatment, and understand how genetic and environmental factors relate to anatomical and functional phenotypes.
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28713915/concurrent-administration-of-thyroxine-and-donepezil-induces-plastic-changes-in-the-prefrontal-cortex-of-adult-hypothyroid-rats
#2
Fen Wang, Zhangbi Wu, Xiaoxue Zha, Yaojun Cai, Bo Wu, Xuemei Jia, Defa Zhu
The aim of the present study was to observe the effects of the concurrent administration of thyroxine (T4) and an acetylcholinesterase (AChE) inhibitor, donepezil (DON), on the hypothyroidism‑induced ultrastructural changes of the prefrontal cortex (PFC) in adult rats. The acetylcholine (ACh) content and AChE activity was assessed, as well as the expressions of synaptotagmin‑1 (syt‑1) and SNAP‑25 were analyzed in the rats. Adding 0.05% propylthiouracil to rats' drinking water induced a hypothyroid rat model...
July 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713426/3d-morphology-analysis-of-tmj-articular-eminence-in-magnetic-resonance-imaging
#3
Izabella Nascimento Falcão, Maria Beatriz Carrazzone Cal Alonso, Lucas Hian da Silva, Sérgio Lúcio Pereira de Castro Lopes, Lívia Pichi Comar, André Luiz Ferreira Costa
PURPOSE: The objective of this study was to evaluate the computational reconstruction of the articular eminence of the temporomandibular joint (TMJ) based on magnetic resonance imaging (MRI) and semiautomatic volumetric segmentation techniques for morphological classification of the TMJ structure. MATERIALS AND METHODS: A total of 36 MRI scans of TMJ individuals were selected and formatted by using the ITK-SNAP software, consisting of MRI segmentation and generation of 3D models...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28712812/peroxynitrite-footprint-in-circulating-neutrophils-of-abdominal-aortic-aneurysm-patients-is-lower-in-statin-than-in-non-statin-users
#4
M E Groeneveld, J J van der Reijden, G J Tangelder, L C Westin, L Renwarin, R J P Musters, W Wisselink, K K Yeung
OBJECTIVES: Extensive reactive oxygen and nitrogen species (also reactive species) production is a mechanism involved in abdominal aortic aneurysm (AAA) development. White blood cells (WBCs) are a known source of reactive species. Their production may be decreased by statins, thereby reducing the AAA growth rate. Reactive species production in circulating WBCs of AAA patients and the effect of statins on their production was investigated. METHODS: This observational study investigated reactive species production in vivo and ex vivo in circulating WBCs of AAA patients, using venous blood from patients prior to elective AAA repair (n = 34; 18 statin users) and from healthy volunteers (n = 10)...
July 14, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28711355/characterization-of-the-foxl2-proximal-promoter-and-coding-sequence-from-the-common-snapping-turtle-chelydra-serpentina
#5
Lei Guo, Turk Rhen
Sex is determined by temperature during embryogenesis in snapping turtles, Chelydra serpentina. Previous studies in this species show that dihydrotestosterone (DHT) induces ovarian development at temperatures that normally produce males or mixed sex ratios. The feminizing effect of DHT is associated with increased expression of FoxL2, suggesting that androgens regulate transcription of FoxL2. To test this hypothesis, we cloned the proximal promoter (1.6kb) and coding sequence for snapping turtle FoxL2 (tFoxL2) in frame with mCherry to produce a fluorescent reporter...
July 12, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28706800/arthroscopic-screw-removal-after-arthroscopic-latarjet-procedure
#6
Thibault Lafosse, Lior Amsallem, Damien Delgrande, Antoine Gerometta, Laurent Lafosse
Arthroscopic Latarjet procedure is an efficient and reliable approach for the treatment of shoulder instability. Nevertheless, the screws fixing the bone block may sometimes be responsible for pain and uncomfortable snapping in the shoulder that is triggered during active external rotation. We propose an all-arthroscopic technique for screw removal in cases of complications involving the screws from a Latarjet procedure. The all-arthroscopic screw removal is reliable and efficient. This procedure is indicated in more cases than thought because of the bone block resorption...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706781/assessment-of-condyle-masseter-and-temporal-muscles-volumes-in-patients-with-juvenile-systemic-lupus-erythematosus-a-cross-sectional-study
#7
Sandra Lucia Golin, Nailu Angélica Sinicato, Karyna Valle-Corotti, Acácio Fuziy, Ana Carla Nahas-Scocate, Simone Appenzeller, Andre Luiz Ferreira Costa
AIMS: The purpose of this study was to evaluate the effect of the corticosteroid therapy for both treatment of juvenile systemic lupus erythematosus and disease activity on two masticatory muscles and condyle of the temporomandibular joint. METHODS: A total of 21 controls and 48 juvenile systemic lupus erythematosus patients were investigated. Volumes of the temporal and masseter muscles and condyle of the subjects were assessed by using a 3D reconstruction in magnetic resonance imaging...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28706066/snap-deconvolution-an-informatics-approach-to-high-throughput-discovery-of-catalytic-reactions
#8
Konstantin Troshin, John F Hartwig
We present an approach to multidimensional high-throughput discovery of catalytic coupling reactions that integrates molecular design with automated analysis and interpretation of mass spectral data. We simultaneously assessed the reactivity of three pools of compounds that shared the same functional groups (halides, boronic acids, alkenes, and alkynes, among other groups) but carried inactive substituents having specifically designed differences in masses. The substituents were chosen such that the products from any class of reaction in multiple reaction sets would have unique differences in masses, thus allowing simultaneous identification of the products of all transformations in a set of reactants...
July 14, 2017: Science
https://www.readbyqxmd.com/read/28705076/elucidation-of-stable-intermediates-in-urea-induced-unfolding-pathway-of-human-carbonic-anhydrase-ix
#9
Amresh Prakash, Gunjan Dixit, Naveen Kumar Meena, Ruhar Singh, Poonam Vishwakarma, Smriti Mishra, Andrew M Lynn
Human carbonic anhydrase IX (CAIX) has evolved as a promising biomarker for cancer prognosis, due to its overexpression in various cancer and restricted expression in normal tissue. However, limited information is available on its biophysical behavior. The unfolding of CAIX in aqueous urea solution was studied using all-atom molecular dynamics simulation approach. The results of this study revealed a stable intermediate state along the unfolding pathway of CAIX. At intermediate concentrations of urea (2.0-4...
July 14, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28702825/olfactory-dysfunction-and-quality-of-life-in-patients-with-transfusion-dependent-thalassemia
#10
Yasin Yilmaz, Zeynep Karakas, Busra Uzun, Comert Sen, Senol Comoglu, Kadir Serkan Orhan, Selime Aydogdu, Ayse Ozkan Karagenc, Deniz Tugcu, Serap Karaman, Crystal Wylie, Richard L Doty
Transfusion-dependent thalassemia (TDT) is a group of thalassemia syndromes that require regular blood transfusions for survival. It is unknown whether the sense of smell of patients with TDT is affected, and if so, whether smell loss has an adverse effect on quality of life (QOL). Olfactory thresholds were measured using Snap & Sniff(®) wands. QOL was assessed via the Short Form-36 (SF-36) questionnaire. Forty-two TDT patients from the Thalassemia Center in Istanbul Medical Faculty were tested (mean age 26...
July 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28702450/effects-of-taping-therapy-for-carpal-space-expansion-on-electrophysiological-change-in-patients-with-carpal-tunnel-syndrome
#11
Yeong-Dong Park, Yun-Jin Park, Sang-Seo Park, Hae-Lim Lee, Hyeong-Hun Moon, Myung-Ki Kim
Taping therapy is one of the most conservative treatments for carpal tunnel syndrome (CTS). Preceding research studied on pain control, grip strength, and wrist function but no studies have been reported on electrophysiolgical changes after taping therapy. The aim of this study is to evaluate the effects of taping therapy for carpal space expansion on electrophysiological in 20 female patients aged from 40s to 60s with CTS. Experimental group applied taping therapy for carpal space expansion twice a week for 4 weeks and control group did not...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28701699/dynamics-of-snap-off-and-pore-filling-events-during-two-phase-fluid-flow-in-permeable-media
#12
Kamaljit Singh, Hannah Menke, Matthew Andrew, Qingyang Lin, Christoph Rau, Martin J Blunt, Branko Bijeljic
Understanding the pore-scale dynamics of two-phase fluid flow in permeable media is important in many processes such as water infiltration in soils, oil recovery, and geo-sequestration of CO2. The two most important processes that compete during the displacement of a non-wetting fluid by a wetting fluid are pore-filling or piston-like displacement and snap-off; this latter process can lead to trapping of the non-wetting phase. We present a three-dimensional dynamic visualization study using fast synchrotron X-ray micro-tomography to provide new insights into these processes by conducting a time-resolved pore-by-pore analysis of the local curvature and capillary pressure...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700036/computerized-cognitive-training-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-as-add-on-treatment-to-stimulants-feasibility-study-and-protocol-description
#13
Virginia de Oliveira Rosa, Marcelo Schmitz, Carlos Roberto Moreira-Maia, Flavia Wagner, Igor Londero, Caroline de Fraga Bassotto, Guilherme Moritz, Caroline Dos Santos de Souza, Luis Augusto Paim Rohde
Background: Cognitive training has received increasing attention as a non-pharmacological approach for the treatment of attention deficit/hyperactivity disorder (ADHD) in children and adolescents. Few studies have assessed cognitive training as add-on treatment to medication in randomized placebo controlled trials. The purpose of this preliminary study was to explore the feasibility of implementing a computerized cognitive training program for ADHD in our environment, describe its main characteristics and potential efficacy in a small pilot study...
April 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28698636/standardized-nanomechanical-atomic-force-microscopy-procedure-snap-for-measuring-soft-and-biological-samples
#14
Hermann Schillers, Carmela Rianna, Jens Schäpe, Tomas Luque, Holger Doschke, Mike Wälte, Juan José Uriarte, Noelia Campillo, Georgios P A Michanetzis, Justyna Bobrowska, Andra Dumitru, Elena T Herruzo, Simone Bovio, Pierre Parot, Massimiliano Galluzzi, Alessandro Podestà, Luca Puricelli, Simon Scheuring, Yannis Missirlis, Ricardo Garcia, Michael Odorico, Jean-Marie Teulon, Frank Lafont, Malgorzata Lekka, Felix Rico, Annafrancesca Rigato, Jean-Luc Pellequer, Hans Oberleithner, Daniel Navajas, Manfred Radmacher
We present a procedure that allows a reliable determination of the elastic (Young's) modulus of soft samples, including living cells, by atomic force microscopy (AFM). The standardized nanomechanical AFM procedure (SNAP) ensures the precise adjustment of the AFM optical lever system, a prerequisite for all kinds of force spectroscopy methods, to obtain reliable values independent of the instrument, laboratory and operator. Measurements of soft hydrogel samples with a well-defined elastic modulus using different AFMs revealed that the uncertainties in the determination of the deflection sensitivity and subsequently cantilever's spring constant were the main sources of error...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698291/bioprosthetic-valve-fracture-improves-the-hemodynamic-results-of-valve-in-valve-transcatheter-aortic-valve-replacement
#15
Adnan K Chhatriwalla, Keith B Allen, John T Saxon, David J Cohen, Sanjeev Aggarwal, Anthony J Hart, Suzanne J Baron, Danny Dvir, A Michael Borkon
BACKGROUND: Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) may be less effective in small surgical valves because of patient/prosthesis mismatch. Bioprosthetic valve fracture (BVF) using a high-pressure balloon can be performed to facilitate VIV TAVR. METHODS AND RESULTS: We report data from 20 consecutive clinical cases in which BVF was successfully performed before or after VIV TAVR by inflation of a high-pressure balloon positioned across the valve ring during rapid ventricular pacing...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28694530/transcriptomic-profiling-of-hemp-bast-fibres-at-different-developmental-stages
#16
Gea Guerriero, Marc Behr, Sylvain Legay, Lauralie Mangeot-Peter, Simone Zorzan, Mohammad Ghoniem, Jean-Francois Hausman
Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, while the latter, found in tension wood, as well as flax, ramie and hemp bast fibres, have a high abundance of crystalline cellulose. During their differentiation, bast fibres undergo specific developmental stages: the cells initially elongate rapidly by intrusive growth, subsequently they cease elongation and start to thicken...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693243/rt-qpcr-for-phox2b-mrna-is-a-highly-specific-and-sensitive-method-to-assess-neuroblastoma-minimal-residual-disease-in-testicular-tissue
#17
Victoria Grèze, Justyna Kanold, Fanny Chambon, Pascale Halle, Anne-Sophie Gremeau, Nathalie Rives, Nadège Rouel, Bruno Pereira, Andrei Tchirkov, Florence Brugnon
Neuroblastoma (NB) is the most common type of extracranial solid tumor in children with a high prevalence in toddlers. For childhood cancer survivors, preservation of reproductive potential is an important factor for quality of life. The optimization of NB minimal residual disease (MRD) detection in testicular tissue is crucial to evaluate the risk of malignant cell reintroduction. The first step in the present study was to assess the accuracy of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to detect tyrosine hydroxylase (TH), paired-like homeobox 2b (PHOX2B) and doublecortin (DCX) mRNA expression in frozen/thawed testicular tissues of patients with non-obstructive azoospermia (NOA) contaminated (in vitro model) with an increasing number of IMR-32 and SK-N-SH NB cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692698/nitric-oxide-attenuates-overexpression-of-gi%C3%AE-proteins-in-vascular-smooth-muscle-cells-from-shr-role-of-ros-and-ros-mediated-signaling
#18
Oli Sarkar, Yuan Li, Madhu B Anand-Srivastava
Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit decreased levels of nitric oxide (NO) that may be responsible for the overexpression of Giα proteins that has been shown as a contributing factor for the pathogenesis of hypertension in SHR. The present study was undertaken to investigate if increasing the intracellular levels of NO by NO donor S-Nitroso-N-acetyl-DL-penicillamine (SNAP) could attenuate the enhanced expression of Giα proteins in VSMC from SHR and explore the underlying mechanisms responsible for this response...
2017: PloS One
https://www.readbyqxmd.com/read/28692274/solid-state-15-n-and-17-o-nmr-studies-of-s-nitrosothiols
#19
Yin Gao, Yizhe Dai, Gang Wu
We report a solid-state 15N and 17O NMR study of two representative S-nitrosothiols (RSNO): S-nitroso N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO). The 15N and 17O NMR tensors are experimentally determined for the first time for this important class of nitric oxide (NO)-related compounds. The observed NMR characteristics for RSNO include large 15N and 17O chemical shift anisotropies and large 17O quadrupole coupling constants. Quantum chemical calculations are also performed for the 15N and 17O NMR tensors in two simple RSNO models: t-BuSNO and MeSNO...
July 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28689925/a-geographical-workforce-analysis-of-hand-therapy-services-in-relation-to-us-population-characteristics
#20
Caroline W Stegink-Jansen, Prisca M Collins, Ronald W Lindsey, James L Wilson
INTRODUCTION: A paucity of work force planning literature exists for hand therapy services. PURPOSE: This descriptive study aimed to map the geographical distribution of US Certified Hand Therapists (CHT) and describe characteristics of US populations living in respective CHT workplace areas. METHODS: A de-identified Zip Code list of all active CHTs through April 2016 from the Hand Therapy Certification Commission, included 5572 CHTs with US Census Zip Code Tabulation Areas (ZCTA)...
July 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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