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https://www.readbyqxmd.com/read/29792103/prolonged-use-of-antibiotics-after-birth-is-associated-with-increased-morbidity-in-preterm-infants-with-negative-cultures
#1
C Fajardo, B Alshaikh, A Harabor
BACKGROUND: Most preterm infants are exposed to a variable duration of antibiotic therapy after birth despite negative cultures. Data is emerging about the risks of prolonged antibiotics. We sought to assess the association between length of initial antibiotic course and neonatal outcomes in a cohort from a single large perinatal centre. METHODS: Retrospective cohort study of prospectively collected data on all infants with a birth weight of less than 1250 g hospitalized in our NICU in a 4-year window and who had negative blood and CSF cultures in the first 2 days of life...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29789252/a-history-of-anterior-cruciate-ligament-reconstruction-at-the-national-football-league-combine-results-in-inferior-early-national-football-league-career-participation
#2
Matthew T Provencher, James P Bradley, Jorge Chahla, Anthony Sanchez, Brendin R Beaulieu-Jones, Justin W Arner, Nicholas I Kennedy, George Sanchez, Mitchell I Kennedy, Gilbert Moatshe, Mark E Cinque, Robert F LaPrade
PURPOSE: To evaluate whether players with a history of an anterior cruciate ligament reconstruction (ACLR) before the National Football League (NFL) Combine played or started fewer games and/or participated in fewer eligible snaps compared with NFL Combine participants without a history of knee injury or surgery. METHODS: We performed a retrospective review of all players who participated in the NFL Combine between 2009 and 2015 and who had a history of an ACLR...
May 19, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29785964/mechanism-of-selective-recruitment-of-rna-polymerases-ii-and-iii-to-snrna-gene-promoters
#3
Oleksandr Dergai, Pascal Cousin, Jerome Gouge, Karishma Satia, Viviane Praz, Tracy Kuhlman, Philippe Lhôte, Alessandro Vannini, Nouria Hernandez
RNA polymerase II (Pol II) small nuclear RNA (snRNA) promoters and type 3 Pol III promoters have highly similar structures; both contain an interchangeable enhancer and "proximal sequence element" (PSE), which recruits the SNAP complex (SNAPc). The main distinguishing feature is the presence, in the type 3 promoters only, of a TATA box, which determines Pol III specificity. To understand the mechanism by which the absence or presence of a TATA box results in specific Pol recruitment, we examined how SNAPc and general transcription factors required for Pol II or Pol III transcription of SNAPc-dependent genes (i...
May 21, 2018: Genes & Development
https://www.readbyqxmd.com/read/29779092/neurodynamic-evaluation-and-nerve-conduction-studies-in-patients-with-forward-head-posture
#4
Tugba Ozudogru Celik, Burcu Duyur Cakit, Baris Nacir, Hakan Genc, Mehmet Onat Cakit, Aynur Karagoz
Forward head posture (FHP) is one of the most frequently seen problems. The aim of this study was to evaluate the neurodynamic tests and peripheral nerve conductions of upper extremity in patients with FHP. The study population included 100 patients with upper extremity and neck problems and 34 healthy individuals as a control group. Craniovertebral angle measurement was used to determine forward head posture. Stretch tests for radial, ulnar and median nerves were performed. Nerve conductions of bilateral median, radial, ulnar and medial antebrachial cutaneous (MAC) nerves were examined in all patients included in the study...
May 19, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29776786/increases-in-sugary-drink-marketing-during-supplemental-nutrition-assistance-program-benefit-issuance-in-new-york
#5
Alyssa J Moran, Aviva Musicus, Mary T Gorski Findling, Ian F Brissette, Ann A Lowenfels, S V Subramanian, Christina A Roberto
INTRODUCTION: The Supplemental Nutrition Assistance Program (SNAP) is the largest federal food assistance program, providing $67 billion in benefits to 44 million Americans. Some states distribute SNAP benefits over one or a few days each month, which may create an incentive for retailers to heavily promote top-selling products, like sugar-sweetened beverages, when benefits are disbursed. METHODS: A beverage environment scan assessing presence of displays, advertisements, and price promotions for sugar-sweetened, low-calorie, and unsweetened beverages was administered in a census of SNAP-authorized beverage retailers (n=630) in three cities in New York from November to September 2011...
May 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29771640/phosphorylation-of-snap-23-at-ser95-causes-a-structural-alteration-and-negatively-regulates-fc-receptor-mediated-phagosome-formation-and-maturation-in-macrophages
#6
Chiye Sakurai, Makoto Itakura, Daiki Kinoshita, Seisuke Arai, Hitoshi Hashimoto, Ikuo Wada, Kiyotaka Hatsuzawa
SNAP-23 is a plasma membrane-localized SNARE protein involved in Fc receptor (FcR)-mediated phagocytosis. However, the regulatory mechanism underlying its function remains elusive. Using phosphorylation specific-antibodies, SNAP-23 was found to be phosphorylated at Ser95 in macrophages. To understand the role of this phosphorylation, we established macrophage lines overexpressing the non-phosphorylatable S95A or the phospho-mimicking S95D mutation. The efficiency of phagosome formation and maturation was severely reduced in SNAP-23-S95D-overexpressing cells...
May 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29768434/plasma-membrane-insertion-of-kca2-3-sk3-is-dependent-upon-the-snare-proteins-syntaxin-4-and-snap23
#7
Claudia A Bertuccio, Tony T Wang, Kirk L Hamilton, Diego J Rodriguez-Gil, Steven B Condliffe, Daniel C Devor
We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent. KCa2.3 then enters Rab35/EPI64C- and RME-1-containing recycling endosomes and is returned to the plasma membrane (PM). Herein, we report on the mechanism by which KCa2.3 is inserted into the PM during recycling and following exit from the Golgi. We demonstrate KCa2.3 colocalizes with SNAP-23 and Syntaxin-4 in the PM of HEK and endothelial cells by confocal immunofluorescence microscopy. We further show KCa2.3 can be co-immunoprecipitated with SNAP-23 and Syntaxin-4...
2018: PloS One
https://www.readbyqxmd.com/read/29765919/assessing-the-validity-of-itk-snap-software-package-in-measuring-the-volume-of-upper-airway-spaces-secondary-to-rapid-maxillary-expansion
#8
Mohammed Almuzian, Hind Mohammed Al Ghatam, Lubna Al-Muzian
INTRODUCTION: The purpose of this study is to evaluate the validity of a free-access software package (ITK-SNAP) in segmenting and measuring the volume of upper airway spaces secondary to rapid maxillary expansion (RME). MATERIALS AND METHODS: Sixteen participants who required RME were recruited for this study. Preoperative (T1) and 6-month postoperative (T2) cone-beam computed tomographic scans of all participants were analyzed. OnDemand3D software packages was used for superimposition and orientation of the images, while ITK-SNAP software was used to measure the volume of airway spaces...
2018: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/29760498/hierarchical-mechanism-of-amino-acid-sensing-by-the-t-box-riboswitch
#9
Krishna C Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P Nikonowicz, Nils G Walter
In Gram-positive bacteria, T-box riboswitches control gene expression to maintain the cellular pools of aminoacylated tRNAs essential for protein biosynthesis. Co-transcriptional binding of an uncharged tRNA to the riboswitch stabilizes an antiterminator, allowing transcription read-through, whereas an aminoacylated tRNA does not. Recent structural studies have resolved two contact points between tRNA and Stem-I in the 5' half of the T-box riboswitch, but little is known about the mechanism empowering transcriptional control by a small, distal aminoacyl modification...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760290/-senile-dementia-of-the-neurofibrillary-tangle-type-sd-nft
#10
Masahito Yamada
A subset of older individuals with dementia have neurofibrillary tangles (NFTs) in the medial temporal lobe and show absence of amyloid β-protein (Aβ) deposition in the brain. In 1996, the author's group reported senile dementia of the NFT type (SD-NFT) as a disease entity characterized by these pathological features as well as late-onset dementia in older subjects. In 2014, it was proposed that this pathological condition, irrespective of the presence of cognitive impairment, should be referred to as primary age-related tauopathy (PART)...
May 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29757716/us-assessment-of-sports-related-hip-injuries
#11
Eugen Lungu, Johan Michaud, Nathalie J Bureau
Traumatic and overuse hip injuries occur frequently in amateur and professional athletes. After clinical assessment, imaging plays an important role in diagnosis and in defining care management of these injuries. Ultrasonography (US) is being increasingly used in assessment of hip injuries because of the wide availability of US machines, the lower cost, and the unique real-time imaging capability, which allows both static and dynamic evaluation as well as guidance of point-of-care interventions such as fluid aspiration and steroid injection...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29757116/social-marketing-nutrition-education-for-low-income-population
#12
Rachel Hagues, Sarah Stotz, Austin Childers, Joe Phua, Judy Hibbs, Deborah Murray, Jung Sun Lee
As access to healthy food (or lack thereof) could be considered a social justice issue, social workers should be concerned about this issue and willing to collaborate with colleagues of various disciplines to address it. This study was a formative evaluation conducted to understand best practices, recommendations, and feasibility of a social-marketing-based nutrition education program tailored to the needs of adults with limited income. The authors report findings from focus groups conducted with Cooperative Extension Agents (CEAs) and region coordinators (n = 45) and Supplemental Nutrition Assistance Program Education (SNAP-Ed) (n = 69) eligible participants to inform the development of a social marketing nutrition intervention for SNAP-Ed in Georgia...
May 14, 2018: Social Work in Public Health
https://www.readbyqxmd.com/read/29754856/three-dimensional-dental-and-craniofacial-manifestations-in-patients-with-late-diagnosis-of-mucopolysaccharidosis-type-ii-report-of-2-cases
#13
Rafaela de Oliveira Torres, Andréa Vaz Braga Pintor, Fábio Ribeiro Guedes, Lucia Helena Soares Cevidanes, Liana Bastos Freitas-Fernandes, Antônio Carlos de Oliveira Ruellas, Ivete Pomarico Ribeiro de Souza
The objective of this study was to report the clinical evaluation results and 3-dimensional (3-D) dental and craniofacial characteristics observed in 2 male patients with mucopolysaccharidosis type II. The patients were evaluated clinically (soft tissue evaluation, evaluation of occlusion, periodontal and dental examinations) and by using craniofacial computed tomography, with evaluation of 3-D images in ITK-Snap v. 2.2 (Penn Image Computing and Science Laboratory, Philadelphia, PA; http://www.itksnap.org/) and 3-D Slicer (http://www...
April 16, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29753414/late-effects-of-1-h-irradiation-on-hippocampal-physiology
#14
Frederico Kiffer, Alexis K Howe, Hannah Carr, Jing Wang, Tyler Alexander, Julie E Anderson, Thomas Groves, John W Seawright, Vijayalakshmi Sridharan, Gwendolyn Carter, Marjan Boerma, Antiño R Allen
NASA's Missions to Mars and beyond will expose flight crews to potentially dangerous levels of charged-particle radiation. Of all charged nuclei, 1 H is the most abundant charged particle in both the galactic cosmic ray (GCR) and solar particle event (SPE) spectra. There are currently no functional spacecraft shielding materials that are able to mitigate the charged-particle radiation encountered in space. Recent studies have demonstrated cognitive injuries due to high-dose 1 H exposures in rodents. Our study investigated the effects of 1 H irradiation on neuronal morphology in the hippocampus of adult male mice...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29753214/snap-crack-and-pop-of-explosive-fruit
#15
REVIEW
Anahit Galstyan, Angela Hay
There is an increasing appreciation for the role of physical forces in plant development. Mechanics are fundamental to how explosive fruit eject their seeds, and recent studies have successfully combined mechanics with developmental genetics to help explain how these dispersal traits are produced and how they evolved. Computational modeling is used more and more to address developmental questions, and explosive fruit are particularly good systems for combining biology and modeling approaches. Finite element models have been recently used to explore questions such as: Why do touch-me-not species with similar fruits, differ so much in how efficiently they transfer stored energy to eject seeds? And how do popping cress fruits use the expansive force of turgor pressure for tissue contraction?...
May 9, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29752896/wavelength-dependence-of-vasodilation-and-no-release-from-s-nitrosothiols-and-dinitrosyl-iron-complexes-by-far-red-near-infrared-light
#16
Agnes Keszler, Brian Lindemer, Neil Hogg, Dorothee Weihrauch, Nicole L Lohr
Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial electron transport chain is considered the primary photoacceptor for R/NIR to photolyze a putative heme nitrosyl in Cco to liberate free nitric oxide (NO). We previously observed R/NIR light directly liberates NO from nitrosylated hemoglobin and myoglobin, and recently suggested S-nitrosothiols (RSNO) and dinitrosyl iron complexes (DNIC) may be primary sources of R/NIR-mediated NO...
May 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29750805/pilot-study-of-placental-tissue-collection-processing-and-measurement-procedures-for-large-scale-assessment-of-placental-inflammation
#17
Lindsey A Sjaarda, Katherine A Ahrens, Daniel L Kuhr, Tiffany L Holland, Ukpebo R Omosigho, Brian T Steffen, Natalie L Weir, Hannah K Tollman, Robert M Silver, Michael Y Tsai, Enrique F Schisterman
BACKGROUND: Placental dysfunction is related to many pregnancy complications, but collecting placental specimens for investigation in large scale epidemiologic studies is often infeasible. Standard procedures involving immediate collection after birth and snap freezing are often cost prohibitive. We aimed to collect pilot data regarding the feasibility and precision of a simpler approach, the collection of tissue samples following 24 hours of refrigeration of whole placentae at 4°C, as compared to the "gold standard" of snap freezing excised tissue within 40 minutes of delivery for the assessment of inflammatory cytokines...
2018: PloS One
https://www.readbyqxmd.com/read/29748418/reductions-in-national-cardiometabolic-mortality-achievable-by-food-price-changes-according-to-supplemental-nutrition-assistance-program-snap-eligibility-and-participation
#18
Parke Edward Wilde, Zach Conrad, Colin D Rehm, Jennifer L Pomeranz, Jose L Penalvo, Frederick Cudhea, Jonathan Pearson-Stuttard, Martin O'Flaherty, Renata Micha, Dariush Mozaffarian
BACKGROUND: Suboptimal diets are a major contributor to cardiometabolic disease (CMD) mortality, and substantial disparities exist for both dietary quality and mortality risk across income groups in the USA. Research is needed to quantify how food pricing policies to subsidise healthy foods and tax unhealthy foods could affect the US CMD mortality, overall and by Supplemental Nutrition Assistance Program (SNAP) eligibility and participation. METHODS: Comparative risk analysis based on national data on diet (National Health and Nutrition Examination Survey, 2003-2012) and mortality (mortality-linked National Health Interview Survey) and meta-analyses of policy-diet and diet-disease relationships...
May 10, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29746384/maximum-movement-workloads-and-high-intensity-workload-demands-by-position-in-ncaa-division-i-collegiate-football
#19
Gabriel J Sanders, Brad Roll, Corey A Peacock, Roger O Kollock
Sanders, GJ, Roll, B, Peacock, CA, and Kollock, RO. Maximum movement workloads and high-intensity workload demands by position in NCAA division I collegiate football. J Strength Cond Res XX(X): 000-000, 2018-The purpose of the study was to quantify the average and maximum (i.e., peak) movement workloads, and the percent of those workloads performed at high intensity by NCAA division I football athletes during competitive games. Using global positioning system devices (Catapult Sports), low, moderate, and high and total multidirectional movement workloads were quantified by each position...
May 2, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29743251/how-the-carnivorous-waterwheel-plant-aldrovanda-vesiculosa-snaps
#20
Anna S Westermeier, Renate Sachse, Simon Poppinga, Philipp Vögele, Lubomir Adamec, Thomas Speck, Manfred Bischoff
The fast motion of the snap-traps of the terrestrial Venus flytrap ( Dionaea muscipula ) have been intensively studied, in contrast to the tenfold faster underwater snap-traps of its phylogenetic sister, the waterwheel plant ( Aldrovanda vesiculosa ). Based on biomechanical and functional-morphological analyses and on a reverse biomimetic approach via mechanical modelling and computer simulations, we identify a combination of hydraulic turgor change and the release of prestress stored in the trap as essential for actuation...
May 16, 2018: Proceedings. Biological Sciences
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