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https://www.readbyqxmd.com/read/28087484/inhibition-of-bacterial-adhesion-and-biofilm-formation-by-dual-functional-textured-and-nitric-oxide-releasing-surfaces
#1
Li-Chong Xu, Yaqi Wo, Mark E Meyerhoff, Christopher A Siedlecki
: In separate prior studies, physical topographic surface modification or nitric oxide (NO) release has been demonstrated to each be an effective approach to inhibit and control bacterial adhesion and biofilm formation on polymeric surfaces. Such approaches can prevent biomaterial-associated infection without causing the antibiotic resistance of the strain. In this work, both techniques were successfully integrated and applied to a polyurethane (PU) biomaterial surface that bears ordered pillar topographies (400/400 nm and 500/500 nm patterns) at the top surface and a S-nitroso-N-acetylpenicillamine (SNAP, NO donor) doped sub-layer in the middle, via a soft lithography two-stage replication process...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087397/elbow-locking-in-a-patient-with-a-congenital-radial-head-dislocation-case-report
#2
Hee-June Kim, Poong-Taek Kim, Hyun-Joo Lee, Maria Florencia Deslivia
Snapping elbow is a rare condition which has various possible causes such as impinged plica, annular ligament, or other extra-articular causes. We report a case of 15-year-old boy who had had snapping elbow and sudden onset flexion contracture of the elbow. Simple radiographs showed bilateral anterior dislocation of hypoplastic radial heads. Magnetic resonance images with the elbow extended as much as possible showed that the annular ligament hemmed the dislocated radial neck. By surgical incision of the annular ligament which checkreined the radial neck, the patients could regain full extension of the elbow...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28079875/early-postnatal-illness-severity-scores-predict-neurodevelopmental-impairments-at-10-years-of-age-in-children-born-extremely-preterm
#3
J W Logan, O Dammann, E N Allred, C Dammann, K Beam, R M Joseph, T M O'Shea, A Leviton, K C K Kuban
OBJECTIVE: A neonatal illness severity score, The Score for Neonatal Acute Physiology-II (SNAP-II), predicts neurodevelopmental impairments at two years of age among children born extremely preterm. We sought to evaluate to what extent SNAP-II is predictive of cognitive and other neurodevelopmental impairments at 10 years of age. STUDY DESIGN: In a cohort of 874 children born before 28 weeks of gestation, we prospectively collected clinical, physiologic and laboratory data to calculate SNAP-II for each infant...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28077912/emptyheaded-a-relational-engine-for-graph-processing
#4
Christopher R Aberger, Susan Tu, Kunle Olukotun, Christopher Ré
There are two types of high-performance graph processing engines: low- and high-level engines. Low-level engines (Galois, PowerGraph, Snap) provide optimized data structures and computation models but require users to write low-level imperative code, hence ensuring that efficiency is the burden of the user. In high-level engines, users write in query languages like datalog (SociaLite) or SQL (Grail). High-level engines are easier to use but are orders of magnitude slower than the low-level graph engines. We present EmptyHeaded, a high-level engine that supports a rich datalog-like query language and achieves performance comparable to that of low-level engines...
June 2016: Proceedings
https://www.readbyqxmd.com/read/28074431/detection-and-specific-elimination-of-egfr-ovarian-cancer-cells-using-a-near-infrared-photoimmunotheranostic-approach
#5
Dirk Bauerschlag, Ivo Meinhold-Heerlein, Nicolai Maass, Andreas Bleilevens, Karen Bräutigam, Wa'el Al Rawashdeh, Stefano Di Fiore, Anke Maria Haugg, Felix Gremse, Julia Steitz, Rainer Fischer, Elmar Stickeler, Stefan Barth, Ahmad Fawzi Hussain
PURPOSE: Targeted theranostics is an alternative strategy in cancer management that aims to improve cancer detection and treatment simultaneously. This approach combines potent therapeutic and diagnostic agents with the specificity of different cell receptor ligands in one product. The success of antibody drug conjugates (ADCs) in clinical practice has encouraged the development of antibody theranostics conjugates (ATCs). However, the generation of homogeneous and pharmaceutically-acceptable ATCs remains a major challenge...
January 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28067230/pyruvate-kinase-type-m2-promotes-tumour-cell-exosome-release-via-phosphorylating-synaptosome-associated-protein-23
#6
Yao Wei, Dong Wang, Fangfang Jin, Zhen Bian, Limin Li, Hongwei Liang, Mingzhen Li, Lei Shi, Chaoyun Pan, Dihan Zhu, Xi Chen, Gang Hu, Yuan Liu, Chen-Yu Zhang, Ke Zen
Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), which is upregulated and phosphorylated in tumours. During exosome secretion, phosphorylated PKM2 serves as a protein kinase to phosphorylate synaptosome-associated protein 23 (SNAP-23), which in turn enables the formation of the SNARE complex to allow exosomes release...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28066743/endoscopic-release-of-internal-snapping-hip-a-review-of-literature
#7
Alessio Giai Via, Attilio Basile, Mauricio Wainer, Carlos Musa, Johnny Padulo, Rodrigo Mardones
BACKGROUND: Internal snapping hip is a common clinical condition, characterized by an audible or palpable snap of the medial compartment of the hip. In most cases it is asymptomatic, while in a few patients, mostly in athletes who participate in activities requiring extremes of hip range of motion, the snap may become painful (internal snapping hip syndrome - ISHS). MATERIALS AND METHODS: This is a review of current literature, focused on the pathogenesis, diagnosis and treatment of ISHS...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28048429/we-h-207a-07-image-based-versus-atlas-based-internal-dosimetry
#8
M Fallahpoor, M Abbasi, A Parach, F Kalantari
PURPOSE: Monte Carlo (MC) simulation is known as the gold standard method for internal dosimetry. It requires radionuclide distribution from PET or SPECT and body structure from CT for accurate dose calculation. The manual or semi-automatic segmentation of organs from CT images is a major obstacle. The aim of this study is to compare the dosimetry results based on patient's own CT and a digital humanoid phantom as an atlas with pre-specified organs. METHODS: SPECT-CT images of a 50 year old woman who underwent bone pain palliation with Samarium-153 EDTMP for osseous metastases from breast cancer were used...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047941/su-f-t-372-surface-and-peripheral-dose-in-compensator-based-fff-beam-imrt
#9
D Zhang, V Feygelman, E Moros, K Latifi, S Hoffe, J Frakes, G Zhang
PURPOSE: Flattening filter free (FFF) beams produce higher dose rates. Combined with compensator IMRT techniques, the dose delivery for each beam can be much shorter compared to the flattened beam MLC-based or compensator-based IMRT. This 'snap shot' IMRT delivery is beneficial to patients for tumor motion management. Due to softer energy, surface doses in FFF beam treatment are usually higher than those from flattened beams. Because of less scattering due to no flattening filter, peripheral doses are usually lower in FFF beam treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047606/su-g-bra-04-simulation-of-errors-in-maximal-intensity-projection-mip-based-lung-tumor-internal-target-volumes-itv-using-real-time-2d-mri-and-deformable-image-registration-based-lung-tumor-tracking
#10
D Thomas, A Kishan, A Santhanam, Y Min, D O'Connell, J Lamb, M Cao, N Agazaryan, Y Yang, P Lee, D Low
PURPOSE: To evaluate the effect of inter- and intra-fractional tumor motion on the error in four-dimensional computed tomography (4DCT) maximal intensity projection (MIP)-based lung tumor internal target volumes (ITV), using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatment on the ViewRay, with dose prescribed to PTV (4DCT MIP-based ITV+3-6mm margin)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047276/su-f-t-165-daily-qa-analysis-for-spot-scanning-beamline
#11
F Poenisch, M Gillin, N Sahoo, C Martin, X Zhu
PURPOSE: The dosimetric results of our daily quality assurance over the last 8 years for discrete pencil beam scanning proton therapy will be presented. METHODS: To perform the dosimetric checks, a multi-ion chamber detector is used, which consists of an array of 5 single parallel plate ion chambers that are aligned as a cross separated by 10cm each. The Tracker is snapped into a jig, which is placed on the tabletop. Different amounts of Solid Water buildup are added to shift the dose distribution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046694/su-f-j-25-position-monitoring-for-intracranial-srs-using-brainlab-exactrac-snap-verification
#12
S Jang, T McCaw, M Huq
PURPOSE: To determine the accuracy of position monitoring with BrainLAB ExacTrac snap verification following couch rotations during intracranial SRS. METHODS: A CT scan of an anthropomorphic head phantom was acquired using 1.25mm slices. The isocenter was positioned near the centroid of the frontal lobe. The head phantom was initially aligned on the treatment couch using cone-beam CT, then repositioned using ExacTrac x-ray verification with residual errors less than 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039971/investigation-of-snap-through-and-homoclinic-bifurcation-of-a-magnet-induced-buckled-energy-harvester-by-the-melnikov-method
#13
H T Li, J Zu, Y F Yang, W Y Qin
Snap-through is used to improve the efficiencies of energy harvesters and extend their effective frequency bandwidths. This work uses the Melnikov method to explore the underlying snap-through mechanism and the conditions necessary for homoclinic bifurcations in a magnet-induced buckled energy harvester. First, an electromechanical model of the energy harvester is established analytically using the Euler-Bernoulli beam theory and the extended Hamilton's principle. Second, the Melnikov function of the model is derived, and the necessary conditions for homoclinic bifurcations and chaos are presented on the basis of this model...
December 2016: Chaos
https://www.readbyqxmd.com/read/28033683/snare-proteins-play-a-role-in-motor-axon-guidance-in-vertebrates-and-invertebrates
#14
Pablo José Barrecheguren, Oriol Ros, Tiziana Cotrufo, Beat Kunz, Eduardo Soriano, Fausto Ulloa, Esther T Stoeckli, Sofia J Araújo
Axonal growth and guidance rely on correct growth cone responses to guidance cues, both in the central nervous system (CNS) and in the periphery. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between guidance and membrane dynamics and turnover in the axon. Our studies have shown that Netrin-1/Deleted in Colorectal Cancer (DCC) signaling triggers exocytosis through the SNARE Syntaxin-1 (STX-1) during the formation of commissural pathways...
December 29, 2016: Developmental Neurobiology
https://www.readbyqxmd.com/read/28029686/comparison-of-four-different-nerve-conduction-techniques-of-the-superficial-fibular-sensory-nerve
#15
Mathew R Saffarian, Nathan C Condie, Erica A Austin, Katie E McCausland, Michael T Andary, James R Sylvain, Iian R Mull, Eric D Zemper, Mary L Jannausch
INTRODUCTION: There are many different nerve conduction study (NCS) techniques to study the superficial fibular sensory nerve (SFSN). OBJECTIVES: We present reference distal latency values and comparative data regarding 4 different NCS for the SFSN. METHODS: Four different NCS techniques, Spartan technique (ST), Izzo techniques-medial and intermediate dorsal cutaneous branches- (IMT and IIT), and Daube technique, were performed on (114) healthy volunteers...
December 28, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/28017594/delivering-summer-electronic-benefit-transfers-for-children-through-the-supplemental-nutrition-assistance-program-or-the-special-supplemental-nutrition-program-for-women-infants-and-children-benefit-use-and-impacts-on-food-security-and-foods-consumed
#16
Anne R Gordon, Ronette R Briefel, Ann M Collins, Gretchen M Rowe, Jacob A Klerman
BACKGROUND: The Summer Electronic Benefit Transfers for Children (SEBTC) demonstration piloted summer food assistance through electronic benefit transfers (EBTs), providing benefits either through the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) or the Supplemental Nutrition Assistance Program (SNAP) EBT. OBJECTIVE: To inform food assistance policy and describe how demonstrations using WIC and SNAP models differed in benefit take-up and impacts on food security and children's food consumption...
December 22, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28011268/nip-snap-1-and-2-mitochondrial-proteins-are-maintained-by-heat-shock-protein-60
#17
Soh Yamamoto, Tomoya Okamoto, Noriko Ogasawara, Shin Hashimoto, Tsukasa Shiraishi, Toyotaka Sato, Keisuke Yamamoto, Hiroyuki Tsutsumi, Kenichi Takano, Testuo Himi, Hideaki Itoh, Shin-Ichi Yokota
NIP-SNAP-1 and -2 are ubiquitous proteins thought to be associated with maintenance of mitochondrial function, neuronal transmission, and autophagy. However, their physiological functions remain largely unknown. To elucidate their functional importance, we screened for proteins that interact with NIP-SNAP-1 and -2, resulting in identification of HSP60 and P62/SQSTM1 as binding proteins. NIP-SNAP-1 and -2 localized in the mitochondrial inner membrane space, whereas HSP60 localized in the matrix. Native gel electrophoresis and filter trap assays revealed that human HSP60 prevented aggregation of newly synthesized NIP-SNAP-2 in an in vitro translation system...
December 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28008214/displacement-sensing-based-on-resonant-frequency-monitoring-of-electrostatically-actuated-curved-micro-beams
#18
Naftaly Krakover, B Robert Ilic, Slava Krylov
The ability to control nonlinear interactions of suspended mechanical structures offers a unique opportunity to engineer rich dynamical behavior that extends the dynamic range and ultimate device sensitivity. We demonstrate a displacement sensing technique based on resonant frequency monitoring of curved, doubly clamped, bistable micromechanical beams interacting with a movable electrode. In this configuration, the electrode displacement influences the nonlinear electrostatic interactions, effective stiffness and frequency of the curved beam...
November 2016: Journal of Micromechanics and Microengineering: Structures, Devices, and Systems
https://www.readbyqxmd.com/read/28008145/msh2-brca1-expression-as-a-dna-repair-signature-predicting-survival-in-early-stage-lung-cancer-patients-from-the-ifct-0002-phase-3-trial
#19
Guénaëlle Levallet, Fatéméh Dubois, Pierre Fouret, Martine Antoine, Solenn Brosseau, Emmanuel Bergot, Michèle Beau-Faller, Valérie Gounant, Elisabeth Brambilla, Didier Debieuvre, Olivier Molinier, Françoise Galateau-Sallé, Julien Mazieres, Elisabeth Quoix, Jean-Louis Pujol, Denis Moro-Sibilot, Alexandra Langlais, Franck Morin, Virginie Westeel, Gérard Zalcman
INTRODUCTION: DNA repair is a double-edged sword in lung carcinogenesis. When defective, it promotes genetic instability and accumulated genetic alterations. Conversely these defects could sensitize cancer cells to therapeutic agents inducing DNA breaks. METHODS: We used immunohistochemistry (IHC) to assess MSH2, XRCC5, and BRCA1 expression in 443 post-chemotherapy specimens from patients randomized in a Phase 3 trial, comparing two neoadjuvant regimens in 528 Stage I-II non-small cell lung cancer (NSCLC) patients (IFCT-0002)...
December 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002906/tears-of-popliteomeniscal-fascicles-diagnostic-and-clinical-implications-a-review-of-the-evidence
#20
R Papalia, R Simonetta, G Di Vico, G Torre, L Saccone, J Espregueira-Mendes, V Denaro
Postero-lateral corner of the knee is composed of several structures including the popliteo-meniscal fascicles (PMFs). These fibrous structures form a stable ligamentous complex around the popliteus tendon, which stabilize the lateral meniscus, increasing the strength of postero-lateral corner. Studies were retrieved through an electronic search of CINAHL, EMBASE, and Pub-Med, until May 2016. Studies in English, Italian, French, and Spanish were considered for inclusion. Randomized controlled trials, prospective and retrospective comparative studies, case series, and case reports were included...
October 2016: Journal of Biological Regulators and Homeostatic Agents
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