Feifei Zhang, Jun Sun, Xiaofeng Tang, Yiping Liang, Quanhui Jiao, Bo Yu, Zhengzai Dai, Xuhui Yuan, Jiayu Li, Jinhua Yan, Zhiping Zhang, Song Fan, Min Wang, Haiyan Hu, Changhua Zhang, Xiao-Bin Lv
Cytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML patients. The expression of SAMHD1, a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, has been reported to be elevated in Ara-C-resistant AML patients and to play a crucial role in mediating Ara-C resistance in AML. However, the mechanism by which SAMHD1 is upregulated in resistant AML remains unknown. In this study, NONO interacted with and stabilized SAMHD1 by inhibiting DCAF1-mediated ubiquitination/degradation of SAMHD1...
July 8, 2022: Cell Death & Disease