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Khaled K Al-Dossari, Sameer Al-Ghamdi, Jamaan Al-Zahrani, Imad Abdulmajeed, Maher Alotaibi, Humoud Almutairi, Abdulrahman BinSwilim, Omar Alhatlan
Introduction: Epilepsy is one of the most stigmatizing disorders. Stigmas and negative attitudes associating epilepsy are due to poor public awareness and knowledge. This study evaluated Saudi public Knowledge, awareness, and attitude towards epilepsy. Materials and Methods: A cross-sectional study conducted during the period from September 16, 2014 to January 1st 2015. A 20-item questionnaire adapted from the literature was validated and distributed to 422 adults living in Al-Kharj governorate, and 22 participants were excluded as they have never heard or read about epilepsy...
January 2018: Journal of Family Medicine and Primary Care
Elaine Xu
No abstract text is available yet for this article.
May 2018: Journal of Thoracic Disease
Yot Teerawattananon, Karlena Luz, Chalarntorn Yothasmutra, Raoh-Fang Pwu, Jeonghoon Ahn, Asrul Akmal Shafie, Kalipso Chalkidou, Sripen Tantivess, Benjarin Santatiwongchai, Waranya Rattanavipapong, Saudamini Dabak
OBJECTIVES: The aim of this study was to describe the historical development of the HTAsiaLink network, draw lessons for other similar initiatives globally, and to analyze key determinants of its success and challenges for its future development. METHODS: This study is based on the collective and direct experiences of the founding members of the HTAsiaLink Network. Data were collected from presentations they made at various international forums and additional information was reviewed...
June 18, 2018: International Journal of Technology Assessment in Health Care
Andreas Møllerløkken
Norway has a long tradition of quality research within the field of baromedicine. With the discovery of oil in the North Sea, it became important to establish scientific research facilities to overcome immediate challenges, but also to work towards long-term goals. For the diving community, an understanding of the pathophysiology of decompression sickness (DCS) has been one of the major forces to maintain focus on the importance of scientific research in this field. In addition to oil, the aquaculture and fish farming industries are increasing in size and are Norway's second biggest export industry today...
June 30, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Beibei Guo, Daniel Li, Ying Yuan
Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses...
June 7, 2018: Pharmaceutical Statistics
Frank Kiwanuka, Carolyne Anyango Olyet
Objective: To assess the knowledge, attitudes, and beliefs of adults on epilepsy in Erute South County, Lira District, Uganda. Methods: A cross-sectional study was conducted in rural Erute South County. Two hundred seventeen of 220 randomly selected adults 18 years or older participated in the study. A standardized self-administered questionnaire (Attitudes towards persons with Epilepsy "ATPE") was used for data collection. Protocol approval was sought from International Health Sciences University, and informed consent was obtained from participants at all times...
June 2018: Epilepsia Open
Jack DiTrapani, Nicholas Rockwood, Minjeong Jeon
No abstract text is available yet for this article.
March 2018: Applied Psychological Measurement
Angela R Bazzi, Melissa A Clark, Michael R Winter, Al Ozonoff, Ulrike Boehmer
PURPOSE: Resilience could help protect the psychosocial wellbeing of sexual minority women (SMW) experiencing stressors from both breast cancer and sexual minority status; however, little research has assessed resilience among breast cancer survivors of different sexual orientations. METHODS: From 2011 to 2012, we surveyed a national sample of breast cancer survivors matched on sexual orientation, age, and cancer status. RESULTS: Among heterosexual (n = 339) and sexual minority (n = 201) breast cancer survivors (n = 540 overall), multivariable regression analyses revealed that more social support (coefficient: 0...
June 7, 2018: LGBT Health
Aschraf Chadli-Debbiche, Emna Abidi, Nèbiha Falfoul-Borsali, Ali Mrabet, Chadli Dziri, Héla Elloumi
INTRODUCTION: The classification of performing universities in the world based on the number of citations of universities scientific publications. However, the rate of publications resulting from theses to the Tunis Faculty of Medicine (FMT) is unknown. OBJECTIVE: To determine the publication rates of theses in indexed journals. METHODS: This is a descriptive study of theses of all specialties, supported in the FMT from 1 January 2008 to 31 December 2010...
October 2017: La Tunisie Médicale
Lei Yang, Shouming Chen, Di Yang, Jiajin Li, Taixiang Wu, Yunxia Zuo
Objective: To learn about the overall quality of clinical anaesthesia study protocols from the Chinese Clinical Trials Registry and to discuss the way to improve study protocol quality. Methods: We defined completeness of each sub-item in SPIRIT as N/A (not applicable) or with a score of 0, 1, or 2. For each protocol, we calculated the proportion of adequately reported items (score = 2 and N/A) and unreported items (score = 0). Protocol quality was determined according to the proportion of reported items, with values >50% indicating high quality...
May 15, 2018: Oncotarget
Mi-Kyung Song, Sandra E Ward, Kenneth Hepburn, Sudeshna Paul, Raj C Shah, Darby J Morhardt
People in the early stages of Alzheimer's disease and related dementias (ADRD) are encouraged to engage in advance care planning (ACP) while they are still competent to appoint a surrogate decision maker and meaningfully participate in ACP discussions with the surrogate. In this NIH Stage I behavioral intervention development trial, we will adapt and test an efficacious ACP intervention, SPIRIT (Sharing Patient's Illness Representation to Increase Trust), with people with mild dementia and their surrogates to promote open, honest discussions while such discussions about end-of-life care are possible...
June 2, 2018: Contemporary Clinical Trials
Amy M Salazar, Kristin J McCowan, Janice J Cole, Martie L Skinner, Bailey R Noell, Jessica M Colito, Kevin P Haggerty, Susan E Barkan
Youth who identify as lesbian, gay, bisexual, transgender, queer/questioning, and two-spirit (LGBTQ2S) are disproportionally represented in the foster care population and often face discrimination within the system. This article summarizes findings from focus groups with youth in care who are LGBTQ2S, foster caregivers, and child welfare workers to explore (a) the unique challenges and support-related needs of youth in care who are LGBTQ2S and their foster caregivers, and (b) strategies for building better relationships between these youth and caregivers...
2018: Child Welfare
Ipek Ensari, Matthew M Burg, Keith M Diaz, Jie Fu, Andrea T Duran, Jerry M Suls, Jennifer A Sumner, Rachel Monane, Jacob E Julian, Shuqing Zhao, William F Chaplin, Daichi Shimbo
INTRODUCTION: The experience of negative emotions (eg, anger, anxiety and sadness) is associated with an increased short-term risk of incident cardiovascular disease (CVD) events, independent of traditional CVD risk factors. Impairment in endothelial function is one possible biological mechanism which may explain the association between negative emotions and incident CVD events. This laboratory-based, single-blind, randomised controlled experimental study aims to investigate the impact of induced negative emotions including anger, anxiety and sadness on endothelial function...
May 31, 2018: BMJ Open
Drew Leder
This article proposes the benefits to be had from an unusual conversation: that between those suffering from chronic pain/illness and from long-term incarceration. Taking a phenomenological approach, a series of experiential commonalities are outlined: pain and illness, like incarceration, can cause (1) a constriction of lived space and the range of possible action; (2) a disruption of lived time, such that one is trapped in an aversive 'now', or ever trying to escape it; (3) isolation, as meaningful social contacts diminish or are ripped away; and (4) disempowerment and depersonalisation, especially when the ill person feels caught within a medical system that can be dehumanising in ways that echo prison life...
June 1, 2018: Medical Humanities
Heather L Reid
No abstract text is available yet for this article.
June 2018: American Journal of Bioethics: AJOB
Furong Sun, Zhenjie Zhuang, Dai Zhang, Yushuai Chen, Shu Liu, Nan Gao, Junping Shi, Bingyuan Wang
Nonalcoholic fatty liver disease is a worldwide health issue and chronic alcohol consumption may have different effects on this disease. This study explored the role of chronic moderate alcohol consumption on high-fat high-cholesterol (HFHC) diet-induced liver fibrosis in a rodent model. Male Sprague-Dawley rats were divided into five groups: standard chow group, standard chow plus Er Guo Tou (EGT, a Chinese spirits made from fermented cereals) group, HFHC group, HFHC plus EGT group, and HFHC plus pure ethanol group...
May 30, 2018: Clinical and Experimental Pharmacology & Physiology
Grzegorz Ciepielowski, Barbara Pacholczyk-Sienicka, Tomasz Frączek, Kamila Klajman, Piotr Paneth, Łukasz Albrecht
BACKGROUND: The production of "Polish Vodka" is restricted by law to the ethyl alcohol of agricultural origins obtained from rye, wheat, barley, oat, triticale and potatoes grown on the territory of the Republic of Poland. The current labeling system should guarantee that the spirit is authentic and of good quality but not all producers are honest. Unfortunately, the authentic "Polish Vodka" is the most often counterfeited by the addition of cheaper and more accessible maize spirits...
May 31, 2018: Journal of the Science of Food and Agriculture
Sayuri Kodama, Sugako Kurimori, Tanji Hoshi
Objectives As an indicator of subjective wellbeing, feelings of happiness assessed based on simple items have not been fully elucidated in terms of its relation to survival during old age. The purpose of this study was to examine whether the predictive validity of feelings of happiness assessed using a 4-item measure is high as an indicator of assessing survival three years later, using a variety of factors as adjustment variables among independent, elderly individuals living in a farm village in Okinawa, wherein a spirit of mutual help is prevalent among the residents...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
Anette Langås-Larsen, Anita Salamonsen, Agnete Egilsdatter Kristoffersen, Trine Stub
In Northern Norway, traditional healing has been preserved by passing down the knowledge through generations. Religious prayers of healing (reading) and Sami rituals (curing) are examples of methods that are used. We have examined traditional healers' understanding of traditional healing, the healing process and their own practice, as well as what characteristics healers should have. Semi-structured individual interviews and focus group interviews were conducted among 15 traditional healers in two coastal Sami municipalities in Norway...
December 2018: International Journal of Circumpolar Health
Michael D Rugen, Martin Rejzek, Henrik Naested, Birte Svensson, Robert A Field
The hydrolysis of starch is a key step in plant germination, which also has relevance in the malting and brewing processes for beer and spirit production. Gaps in knowledge about this metabolic process exist that cannot easily be addressed using traditional genetic techniques, due to functional redundancy in many of the enzyme activities required for alpha-glucan metabolism in cereal crop species. Chemical inhibitors provide opportunities to probe the role of carbohydrate-active enzymes and the phenotypes associated with inhibition of specific enzymes...
2018: Methods in Molecular Biology
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