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Phthalate

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https://www.readbyqxmd.com/read/28813539/vectorization-by-nanoparticles-decreases-the-overall-toxicity-of-airborne-pollutants
#1
Rodolphe Carpentier, Anne Platel, Helena Maiz-Gregores, Fabrice Nesslany, Didier Betbeder
Atmospheric pollution is mainly composed of volatile pollutants and particulate matter that strongly interact. However, their specific roles in the induction of cellular toxicity, in particular the impact of the vectorization of atmospheric pollutants by ultrafine particles, remains to be fully elucidated. For this purpose, non-toxic poly-lactic co-glycolic acid (PLGA) nanoparticles were synthesized and three pollutants (benzo(a)pyrene, naphthalene and di-ethyl-hexyl-phthalate) were adsorbed on the surface of the nanoparticles in order to evaluate the toxicity (cytotoxicity, genotoxicity and ROS induction) of these complexes to a human airway epithelial cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28810198/phthalate-metabolites-related-to-infertile-biomarkers-and-infertility-in-chinese-men
#2
Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia, Heqing Shen
Although in vitro and in vivo laboratory studies have demonstrated androgen and anti-androgen effects on male reproduction from phthalate exposures, human studies still remain inconsistent. Therefore, a case-control study (n = 289) was conducted to evaluate the associations between phthalate exposures, male infertility risks, and changes in metabolomic biomarkers. Regional participants consisted of fertile (n = 150) and infertile (n = 139) males were recruited from Nanjing Medical University' affiliated hospitals...
August 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28807416/phthalates-heavy-metals-and-pahs-in-an-overpopulated-coastal-region-inferences-from-abruzzo-central-italy
#3
Francesco Stoppa, Mariangela Schiazza, Jacopo Pellegrini, Francesco Antonio Ambrosio, Gianluigi Rosatelli, Maria R D'Orsogna
Phthalates are an emerging class of environmental pollutants whose distribution and effects in aquatic environments are not well characterized. We analyzed intertidal and emerged beach sediments from the Abruzzo coastline, along the Adriatic Sea, finding significant phthalate concentrations in marine sediments. Phthalate baseline levels in the intertidal environment, marked by substantial interplay of sediment, water and air, were determined. We used statistical rank methods to select representative phthalate compositions, for which we derived risk levels for ingestion, dermal absorption and inhalation...
August 11, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28806671/characterization-and-health-risk-assessment-of-pm2-5-bound-organics-inside-and-outside-of-chinese-smoking-lounges
#4
Lijuan Li, Steven Sai Hang Ho, Judith C Chow, John G Watson, Frank S C Lee, Long Cui, Yuan Gao, Wenting Dai, Kin Fai Ho, Yu Huang, Junji Cao
PM2.5 samples were collected at six indoor public places that contained dedicated smoking lounges. Samples were taken in the smoking lounges, at two indoor locations outside of the lounges, and in outdoor air near the venues. Organic carbon (OC), elemental carbon (EC), and non-polar organic compounds including polycyclic aromatic hydrocarbons (PAHs), n-alkanes (n-C16 to n-C40), iso/anteiso-alkanes (C29 to C33), hopanes and phthalate esters (PAEs) were quantified. Average PM2.5 levels of 170.2 ± 85.9 μg/m(3) in the lounges exceeded limits of 25 μg/m(3) set by World Health Organization (WHO); these levels were 5...
August 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28803130/prenatal-phthalate-exposures-and-child-temperament-at-12-and-24-months
#5
Alison B Singer, Mary S Wolff, Manori J Silva, Antonia M Calafat, Stephanie M Engel
INTRODUCTION: Gestational phthalate exposures have been adversely associated with attention, externalizing, and internalizing behaviors in childhood. Early childhood temperament may be a marker of later behavioral patterns. We therefore sought to determine whether gestational phthalate exposures were associated with infant and toddler temperament. METHODS: The Mount Sinai Children's Environmental Health Study is a prospective cohort study of children born between May 1998 and July 2001 in New York City (N=404)...
August 9, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28801775/plasticizers-and-bisphenol-a-in-packaged-foods-sold-in-the-tunisian-markets-study-of-their-acute-in-vivo-toxicity-and-their-environmental-fate
#6
Asma Beltifa, Anouar Feriani, Monia Machreki, Asma Ghorbel, Lakhdar Ghazouani, Giuseppa Di Bella, Joris Van Loco, Tim Reyns, Hedi Ben Mansour
Today, processed and packaged foods are considered as among the major sources of human exposure to plasticizers and bisphenol which migrate from plastic packing. In the present study, a wide range of food products sold on the Tunisian market such as grain and grain products, milk and dairy products, fats and oil, drink, fish, and sweets have been analyzed firstly in order to identify the presence of phthalates and bisphenol. Then, the identified chemical molecules were studied for their environmental fate and tested in vivo for its toxicity in mice models...
August 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28800814/phthalates-impact-human-health-epidemiological-evidences-and-plausible-mechanism-of-action
#7
REVIEW
Sailas Benjamin, Eiji Masai, Naofumi Kamimura, Kenji Takahashi, Robin C Anderson, Panichikkal Abdul Faisal
Disregarding the rising alarm on the hazardous nature of various phthalates and their metabolites, ruthless usage of phthalates as plasticizer in plastics and as additives in innumerable consumer products continues due low their cost, attractive properties, and lack of suitable alternatives. Globally, in silico computational, in vitro mechanistic, in vivo preclinical and limited clinical or epidemiological human studies showed that over a dozen phthalates and their metabolites ingested passively by man from the general environment, foods, drinks, breathing air, and routine household products cause various dysfunctions...
October 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#8
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28798526/environmental-pollution-and-allergies
#9
REVIEW
Hirohisa Takano, Ken-Ichiro Inoue
Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28797963/packed-nanofiber-solid-phase-extraction-coupled-with-gas-chromatography-mass-spectrometry-for-the-determination-of-phthalate-esters-in-urines-from-children
#10
Zigang Tang, Lanling Chu, Yu Wang, Yuan Song, Ping Liu, Jinhui Fan, Jinjin Huang, Xiongwei Liu, Lanlan Wei, Chen Li, Renshan Zhao, Xuejun Kang
In this paper, we developed a rapid and safe method based on packed-fiber solid-phase extraction (PFSPE) system coupled with gas chromatography-mass spectrometry for the determination of four phthalate esters (PAEs), diethyl-o-phthalate (DEP), dibutyl-o-phthalate (DBP), di (2-ethylhexyl) phathalate (DEHP), di-n-octyl phthalate (DNOP), in urine samples. The PAEs in urine samples (500μL) were rapidly cleaned up from urines using polystyrene (PS) nanofibers packed micro-columns fitted on a PFSPE pretreatment device, which can process up to 12 samples simultaneously in 5min...
July 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28797900/elimination-and-ecotoxicity-evaluation-of-phthalic-acid-esters-from-textile-dyeing-wastewater
#11
Jieying Liang, Xun-An Ning, Minyi Kong, Daohua Liu, Guangwen Wang, Haili Cai, Jian Sun, Yaping Zhang, Xingwen Lu, Yong Yuan
Phthalic acid esters (PAEs), presented in fabrics, surfactants and detergents, were discharged into the ecosystem during textile-dyeing wastewater treatment and might have adverse effects on water ecosystems. In this study, comprehensive investigations of the content and component distributions of 12 PAEs across different units of four textile-dyeing wastewater plants were carried out in Guangdong Province, China. Ecotoxicity assessments were also conducted based on risk quotients (RQs). On average, 93.54% TOC and 80...
August 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28773238/preparation-and-application-of-immobilized-surfactant-modified-pani-cnt-tio%C3%A2-under-visible-light-irradiation
#12
Ching Yuan, Chung-Hsuang Hung, Chung-Shin Yuan, Huei-Wen Li
Hydrothermally and sol-gel-synthesized immobilized surfactant-modified polyaniline-carbon nanotubes/TiO₂ (PANi-CNT/TiO₂) photocatalysts were prepared and their application in the degradation of diethyl phthalate (DEP) under visible light at 410 nm was investigated in this sturdy. To improve the dispersion of nanoparticles and the transfer of electrons, the TiO₂ surface was modified with both sodium dodecyl sulfate (SDS) and functionalized carbon nanotubes (CNT-COOH and CNT-COCl). With the addition of PANi, which was increased from 1%-5%, the adsorption edge of the prepared photocatalysts shifted to 442 nm...
July 29, 2017: Materials
https://www.readbyqxmd.com/read/28771440/association-between-urinary-phthalates-and-metabolic-abnormalities-in-obese-thai-children-and-adolescents
#13
Tansit Saengkaew, Chutima Jantarat, Wichit Nosoognoen, Vichit Supornsilchai
BACKGROUND: Several endocrine disruptors (including phthalates) are considered to be a cause of obesity. However, the current evidence has not conclusively established an association between phthalates and metabolic abnormalities, especially in children. The objective of the study was to evaluate the association between urinary phthalate metabolites and metabolic abnormalities in obese Thai children and adolescents. METHODS: This cross-sectional case-control study was conducted in participants aged 7-18 years and divided into two groups: normal weight and overweight/obesity...
August 3, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28771232/di-2-ethylhexyl-phthalate-exposure-impairs-meiotic-progression-and-dna-damage-repair-in-fetal-mouse-oocytes-in-vitro
#14
Jing-Cai Liu, Fang-Nong Lai, Ling Li, Xiao-Feng Sun, Shun-Feng Cheng, Wei Ge, Yu-Feng Wang, Lan Li, Xi-Feng Zhang, Massimo De Felici, Paul W Dyce, Wei Shen
Di (2-ethylhexyl) phthalate (DEHP), is the most common member of the class of phthalates that are used as plasticizers and have become common environmental contaminants. A number of studies have shown that DEHP exposure impacts reproductive health in both male and female mammals by acting as an estrogen analog. Here, we investigated the effects of DEHP on meiotic progression of fetal mouse oocytes by using an in vitro model of ovarian tissue culture. The results showed that 10 or 100 μM DEHP exposure inhibited the progression of oocytes throughout meiotic prophase I, specifically from the pachytene to diplotene stages...
August 3, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28764020/study-of-the-repartition-of-phthalate-esters-during-distillation-of-wine-for-spirit-production
#15
Giuseppe Montevecchi, Francesca Masino, Nicolas Di Pascale, Giuseppe Vasile Simone, Andrea Antonelli
Due to health concerns and legal matters, an investigation to limit phthalates esters (PEAs) in spirits is necessary. A lab still was used to perform pilot distillations according to the official method for brandy production in order to explore the repartition into the distilled fractions of each PAE. The process was divided in two steps: a première chauffe and a bonne chauffe. The former step included the cut into heads, heart and tails, while the latter into heads, brandy, secondes, and tails. The behaviour of each PAE during distillation was affected by its own chemical nature...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763719/dynamic-responses-of-antioxidant-enzymes-in-pearl-oyster-pinctada-martensii-exposed-to-di-2-ethylhexyl-phthalate-dehp
#16
Nan Xiang, Chunfeng Zhao, Xiaoping Diao, Qian Han, Hailong Zhou
Di(2-ethylhexyl) phthalate (DEHP) is recognized as one of the most ubiquitous contaminants in marine environments and causes adverse effects on the health of marine organisms. The purpose of this study was to investigate the toxic effects of DEHP on the pearl oyster Pinctada martensii. The Pinctada martensii was exposed to 0.0, 0.5, 2, 8, or 32mgL(-1) DEHP for 7 and 10days using parameters of antioxidant. Antioxidant indicators included levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), peroxidase (POD), and total antioxidant capacity (T-AOC) in the gills and hepatopancreas of Pinctada martensii for 7 and 10days...
July 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28763166/comparison-of-three-methods-for-the-methylation-of-aliphatic-and-aromatic-compounds
#17
Hyejung Lee, Sarah J Feakins, Zhiyao Lu, Arndt Schimmelmann, Alex L Sessions, Jessica E Tierney, Travis J Williams
RATIONALE: Methylation protocols commonly call for acidic, hot conditions that are known to promote organic (1) H/(2) H exchange in aromatic and aliphatic C-H bonds. Here we tested two such commonly-used methods and compared a third that avoids these acidic conditions, to quantify isotope effects with each method and to directly determine acidic-exchange rates relevant to experimental conditions. METHODS: We compared acidic and non-acidic methylation approaches catalyzed by hydrochloric acid, acetyl chloride and EDCI (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) / DMAP (4-dimethylaminopyridine) respectively...
August 1, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28761822/optimization-of-chitosan-and-cellulose-acetate-phthalate-controlled-delivery-of-methylprednisolone-for-treatment-of-inflammatory-bowel-disease
#18
Swati Jagdale, Apoorva Chandekar
Purpose: Inflammatory bowel disease (IBD) is a chronic, relapsing and often life-long disorder. The best way to tackle IBD is to develop a site targeted drug delivery. Methylprednisolone is a potent anti-inflammatory steroid. The relative potency of methylprednisolone to hydrocortisone is at least four is to one. The aim of the present research was to develop a colon targeted drug delivery for treatment of IBD. Methods: Compression coated drug delivery system was designed and optimised. Core tablet contained drug, croscarmellose sodium (CCS-superdisintegrant), avicel (binder) and dicalcium phosphate (diluent)...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28760446/in-vitro-to-in-vivo-extrapolation-of-effective-dosimetry-in-developmental-toxicity-testing-application-of-a-generic-pbk-modelling-approach
#19
Styliani Fragki, Aldert H Piersma, Emiel Rorije, Marco J Zeilmaker
Incorporation of kinetics to quantitative in vitro to in vivo extrapolations (QIVIVE) is a key step for the realization of a non-animal testing paradigm, in the sphere of regulatory toxicology. The use of Physiologically-Based Kinetic (PBK) modelling for determining systemic doses of chemicals at the target site is accepted to be an indispensable element for such purposes. Nonetheless, PBK models are usually designed for a single or a group of compounds and are considered demanding, with respect to experimental data needed for model parameterization...
July 28, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28758506/exposure-to-modern-widespread-environmental-endocrine-disrupting-chemicals-and-their-effect-on-the-reproductive-potential-of-women-an-overview-of-current-epidemiological-evidence
#20
Anetta Karwacka, Dorota Zamkowska, Michał Radwan, Joanna Jurewicz
Growing evidence indicates that exposure to widespread, environmental contaminants called endocrine disruptors (EDCs) negatively affects animal and human reproductive health and has been linked to several diseases including infertility. This review aims to evaluate the impact of environmental exposure to endocrine disrupting chemicals [phthalates, parabens, triclosan, bisphenol A (BPA), organochlorine (PCBs) and perfluorinated (PFCs) compounds] on the reproductive potential among women, by reviewing most recently published literature...
July 31, 2017: Human Fertility: Journal of the British Fertility Society
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