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https://www.readbyqxmd.com/read/28092763/growth-and-antioxidant-defense-responses-of-wheat-seedlings-to-di-n-butyl-phthalate-and-di-2-ethylhexyl-phthalate-stress
#1
Minling Gao, Youming Dong, Ze Zhang, Wenhua Song, Yun Qi
Phthalate acid esters (PAEs) are vital environmental hormone-like chemicals that are noxious to plants, animals, and human beings. In this study, the influences of di-n-butyl phthalate (DBP) and di (2-ethylhexyl) phthalate (DEHP) on the seed germination, root morphology, and various physiological changes of wheat seedlings were investigated by analyzing superoxide anion (O2(-)) accumulation, antioxidant enzyme activity, and lipid peroxidation. DBP and DEHP were found to obviously inhibit germination only at high concentrations, but significantly affected root morphology even at lower concentrations...
January 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28091981/environmental-pollutants-limitations-in-physical-functioning-and-frailty-in-older-adults
#2
REVIEW
Esther García-Esquinas, Fernando Rodríguez-Artalejo
PURPOSE OF REVIEW: Frailty is an age-related syndrome characterized by reductions in strength, endurance, and physiologic function that increase an individual's vulnerability for developing dependence or death. Extensive research is currently being conducted to determine preventable risk factors and mechanistic pathways of frailty. This review summarizes the existing evidence on the potential associations between environmental pollutants, limitations in physical functioning, and frailty among older adults...
January 16, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28089693/effects-of-six-priority-controlled-phthalate-esters-with-long-term-low-dose-integrated-exposure-on-male-reproductive-toxicity-in-rats
#3
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, Qian Xu, Shu-Qin Yu
Human beings are inevitably exposed to ubiquitous phthalate esters (PEs) surroundings. The purposes of this study were to investigate the effects of long-term low-dose exposure to the mixture of six priority controlled phthalate esters (MIXPs): dimethyl phthalate (DMP), diethyl phthalate (DEP), di(n-butyl) phthalate (DBP), butyl benzyl phthalate (BBP), di(2-ethyhexyl) phthalate (DEHP) and di-n-octyl phthalate (DNOP), on male rat reproductive system and further to explore the underlying mechanisms of the reproductive toxicity...
January 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28089278/estimating-uptake-of-phthalate-ester-metabolites-into-the-human-nail-plate-using-pharmacokinetic-modelling
#4
Thuy T Bui, Andreia Alves, Anna Palm-Cousins, Stefan Voorspoels, Adrian Covaci, Ian T Cousins
There is a lack of knowledge regarding uptake of phthalate esters (PEs) and other chemicals into the human nail plate and thus, clarity concerning the suitability of human nails as a valid alternative matrix for monitoring long-term exposure. In particular, the relative importance of internal uptake of phthalate metabolites (from e.g. blood) compared to external uptake pathways is unknown. This study provides first insights into the partitioning of phthalate-metabolites between blood and nail using pharmacokinetic (PK) modelling and biomonitoring data from a Norwegian cohort...
January 11, 2017: Environment International
https://www.readbyqxmd.com/read/28088709/characterization-of-smokeless-powders-using-multiplexed-collision-induced-dissociation-mass-spectrometry-and-chemometric-procedures
#5
Kristen L Reese, A Daniel Jones, Ruth Waddell Smith
This work demonstrates a non-targeted mass spectrometry approach for identification of organic compounds in smokeless powders. Unburned powders were removed from various commercial ammunitions of different brand, primer composition, caliber, and age. The unburned powders and corresponding fired residues were analyzed by liquid chromatography-atmospheric pressure chemical ionization-time-of-flight mass spectrometry (LC-APCI-TOFMS). Multiplexed collision-induced dissociation was performed at increasing collision potentials resulting in successive fragmentation that provided structural information for compound identification in a non-targeted manner...
December 21, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28087355/generation-of-quercetin-cellulose-acetate-phthalate-systems-for-delivery-by-supercritical-antisolvent-process
#6
I García-Casas, A Montes, C Pereyra, E J Martínez de la Ossa
Supercritical antisolvent process (SAS) has been used to precipitate microparticles of quercetin, a plant pigment found in many foods and used for medical treatments, pharmaceutical and cosmetic industries, together with nanoparticles of cellulose acetate phthalate (CAP), a polymer quite frequently used in drug delivery. Previously, precipitation of nanoparticles of CAP by the same process was studied at different conditions of pressure, temperature, CO2and solution flow rates, nozzle diameter and initial concentration of the solution...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28081510/gestational-and-lactational-exposure-to-di-isobutyl-phthalate-via-diet-in-maternal-mice-decreases-testosterone-levels-in-male-offspring
#7
Xiaoyang Wang, Nan Sheng, Ruina Cui, Hongxia Zhang, Jianshe Wang, Jiayin Dai
Phthalates are a large family of ubiquitous environmental chemicals suspected of being endocrine disruptors, with exposure to these chemicals during prenatal and postnatal development possibly resulting in reproductive disorders. Di-isobutyl phthalate (DiBP) is widely used in consumer and industrial products, and although its exposure in the general population has increased in recent years, the mechanisms behind DiBP-induced reproductive disorders in male offspring remain unclear. Here, pregnant mice were exposed to 0 or 450 mg/kg bw/day DiBP via diet from gestation day (GD) 0 to GD21...
January 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28081355/oral-delivery-of-probiotics-in-poultry-using-ph-sensitive-tablets
#8
Tao Jiang, Hui-Shan Li, Geon Goo Han, Bijay Singh, Sang-Kee Kang, Jin-Duck Bok, Dae-Duk Kim, Zhong-Shan Hong, Yun-Jaie Choi, Chong-Su Cho
As alternatives to antibiotics in live stocks, probiotics have been used although most of them in the form of liquid or semisolid formulations which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for live stocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxyproyl methylcellulose phthalate 55 (HPMCP 55) as a tablet forming matrix to develop probiotics in a tablet form for poultry...
January 12, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28078517/semivolatile-organic-compounds-in-surface-microlayer-and-subsurface-water-of-dianshan-lake-shanghai-china-implications-for-accumulation-and-interrelationship
#9
Ming-Hong Wu, Xue-Xia Yang, Gang Xu, Chen-Jing Que, Si-Han Ma, Liang Tang
Semivolatile organic compounds (SVOCs) in surface microlayer (SML) and subsurface water (SSW) from Dianshan Lake were studied to investigate their occurrence, distributions, as well as enrichment and potential sources. A sample was concentrated by solid-phase micro-extraction (SPME). Identification and quantification were carried out by gas chromatography coupled to mass spectrometry (GC-MS). Total SVOCs concentrations ranged from 25.93 to 47.49 μg/L in SSW and 38.19 to 77.23 μg/L in SML. The phthalic acid esters (PAE) concentrations in both SSW and SML are the highest of the total SVOC...
January 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28078431/degradation-of-di-2-ethylhexyl-phthalate-by-a-novel-gordonia-alkanivorans-strain-yc-rl2
#10
Ruth Nahurira, Lei Ren, Jinlong Song, Yang Jia, Junhuan Wang, Shuanghu Fan, Haisheng Wang, Yanchun Yan
One bacterial strain, YC-RL2, isolated from petroleum-contaminated soil, could utilize environmental hormone Di(2-Ethylhexyl) phthalate (DEHP) as a sole carbon source for growth. Strain YC-RL2 was identified as Gordonia alkanivorans by 16S rRNA gene analysis and Biolog tests. The effects of environmental factors which might affect the degrading process were optimized at 30 °C and pH 8.0. Strain YC-RL2 showed superior halotolerance and could tolerate up to 0-5% NaCl in trace element medium supplemented with DEHP, although the DEHP degradation rates slowed as NaCl concentration increased...
January 12, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28065941/di2-ethylhexyl-phthalate-disrupts-thyroid-hormone-homeostasis-through-activating-the-ras-akt-trhr-pathway-and-inducing-hepatic-enzymes
#11
Hanfeng Ye, Mei Ha, Min Yang, Ping Yue, Zhengyuan Xie, Changjiang Liu
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28064108/protection-of-male-reproductive-toxicity-in-rats-exposed-to-di-n-butyl-phthalate-during-embryonic-development-by-testosterone
#12
Nelli Giribabu, Pamanji Sreenivasula Reddy
Di-n-butyl phthalate (DBP) widely spread industrial chemical that made drastic alteration in male reproductive system. The present study elucidates the protective role of testosterone on reproductive toxicity in prenatal DBP exposed adult male rats. Pregnant rats were injected with corn oil or 100 and 500mg/kg body weight of DBP on gestation day (GD) 1, 7 and 14. F1 male rats were weaned, injected with either testosterone or vehicle. On postnatal day (PND) 100 F1 adult male rats were cohabited with untreated female rats...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28063697/land-based-sources-of-marine-pollution-pesticides-pahs-and-phthalates-in-coastal-stream-water-and-heavy-metals-in-coastal-stream-sediments-in-american-samoa
#13
Beth A Polidoro, Mia T Comeros-Raynal, Thomas Cahill, Cassandra Clement
The island nations and territories of the South Pacific are facing a number of pressing environmental concerns, including solid waste management and coastal pollution. Here we provide baseline information on the presence and concentration of heavy metals and selected organic contaminants (pesticides, PAHs, phthalates) in 7 coastal streams and in surface waters adjacent to the Futiga landfill in American Samoa. All sampled stream sediments contained high concentrations of lead, and some of mercury. Several coastal stream waters showed relatively high concentrations of diethyl phthalate and of organophosphate pesticides, above chronic toxicity values for fish and other aquatic organisms...
January 4, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28059904/emerging-exposures-of-developmental-toxicants
#14
Mary S Wolff, Jessie Buckley, Stephanie M Engel, Rob S McConnell, Dana B Barr
PURPOSE OF REVIEW: The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less-toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home, and office products; food, water, and air...
January 5, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28058766/synthesis-of-molecularly-imprinted-polymers-by-atom-transfer-radical-polymerization-for-the-solid-phase-extraction-of-phthalate-esters-in-edible-oil
#15
Ningning Chen, Juan He, Chaojun Wu, Yuanyuan Li, An Suo, Hongliang Wei, Lijun He, Shusheng Zhang
Novel molecularly imprinted polymers of phthalate esters were prepared by atom transfer radical polymerization using methyl methacrylate as functional monomer, cyclohexanone as solvent, cuprous chloride as catalyst, 1-chlorine-1-ethyl benzene as initiator and 2,2-bipyridyl as cross-linker in the mixture of methanol and water (1:1, v/v). The effect of reaction conditions such as monomer ratio and template on the adsorption properties was investigated. The optimum condition was obtained by an orthogonal experiment...
January 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28058694/ortho-phthalic-acid-esters-in-lipophilic-extract-from-the-cell-culture-of-aconitum-baicalense-turcz-ex-rapaics-1907
#16
A A Semenov, A G Enikeev, L V Snetkova, A V Permyakov, N A Sokolova, L V Dudareva
Optically active bis-2R(-)ethylhexyl o-phthalate was obtained with 0.18% yield from dry cultured cells of Aconitum baicalense Turcz ex Rapaics 1907 by extraction with petroleum ether followed by silica gel column chromatography. Its structure was confirmed by the analysis of (13)C and (1)H NMR spectra. Seasonal fluctuations of quantitative phthalate content in A. baicalense cells were identified. The tests were performed under conditions excluding the presence of phthalates in reagents, materials, and laboratory dishes...
November 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28054989/effects-of-long-term-in-vivo-exposure-to-di-2-ethylhexylphthalate-on-thyroid-hormones-and-the-tsh-tshr-signaling-pathways-in-wistar-rats
#17
Xinwen Dong, Jin Dong, Yue Zhao, Jipeng Guo, Zhanju Wang, Mingqi Liu, Yunbo Zhang, Xiaolin Na
Di-(2-ethylhexyl)phthalate (DEHP) was a widely used chemical with human toxicity. Recent in vivo and in vitro studies suggested that DEHP-exposure may be associated with altered serum thyroid hormones (THs) levels, but the underlying molecular mechanisms were largely unknown. To explore the possible molecular mechanisms, 128 Wistar rats were dosed with DEHP by gavage at 0, 150, 300, and 600 mg/kg/day for 3 months (M) and 6 M, respectively. After exposure, expression of genes and proteins in the thyroid, pituitary, and hypothalamus tissues of rats were analyzed by Q-PCR and western blot, while the sera and urine samples were assayed by radioimmunoassay and ELISA...
January 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28054450/simultaneous-analysis-of-bisphenol-a-based-compounds-and-other-monomers-leaching-from-resin-based-dental-materials-by-uhplc-ms-ms
#18
Eveline Putzeys, Stevan M Cokic, Hui Chong, Mario Smet, Jeroen Vanoirbeek, Lode Godderis, Bart Van Meerbeek, Kirsten L Van Landuyt, Radu Corneliu Duca
Resin-based dental materials have raised debates concerning their safety and biocompatibility, resulting in a growing necessity of profound knowledge on the quantity of released compounds into the oral cavity. In this context, the aim of this study was to develop a comprehensive and reliable procedure based on liquid chromatography with mass spectrometry for the simultaneous analysis of various leached compounds (including bisphenol A based compounds) in samples from in vitro experiments. Different experiments were performed to determine the optimal analytical parameters, comprising mass spectrometry parameters, chromatographic separation conditions and sample preparation...
January 5, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28049663/reproducibility-of-urinary-biomarkers-in-multiple-24-h-urine-samples
#19
Qi Sun, Kimberly A Bertrand, Adrian A Franke, Bernard Rosner, Gary C Curhan, Walter C Willett
BACKGROUND: Limited knowledge regarding the reproducibility of biomarkers in 24-h urine samples has hindered the collection and use of the samples in epidemiologic studies. OBJECTIVE: We aimed to evaluate the reproducibility of various markers in repeat 24-h urine samples. DESIGN: We calculated intraclass correlation coefficients (ICCs) of biomarkers measured in 24-h urine samples that were collected in 3168 participants in the NHS (Nurses' Health Study), NHSII (Nurses' Health Study II), and Health Professionals Follow-Up Study...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28046217/su-g-tep2-06-development-of-novel-radiochromic-films-for-radiotherapy-dosimetry
#20
M Alqathami, H Lee, G Won Choi, A Blencowe, Z Wen, J Adamovics, G Ibbott
PURPOSE: To develop and evaluate novel radiochromic films for quality assurance in radiotherapy dosimetry. MATERIALS AND METHODS: Novel radiochromic film compositions were formulated using leuco crystal violet (LCV) as a reporting system and tetrabromoethane as a free radical source. The film matrix used consisted of polyurethane polymer mixed with dibutyl phthalate plasticizer (20 wt%). The concentration of the radical initiator was kept constant at 10 wt% and the concentration of the LCV dye varied (1 and 2 wt%)...
June 2016: Medical Physics
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