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Phthalate

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https://www.readbyqxmd.com/read/29150256/reproductive-effects-linked-to-dna-methylation-in-male-zebrafish-chronically-exposed-to-environmentally-relevant-concentrations-of-di-2-ethylhexyl-phthalate
#1
Yan-Bo Ma, Pan-Pan Jia, Muhammad Junaid, Li Yang, Chun-Jiao Lu, De-Sheng Pei
Di-(2-ethylhexyl) phthalate (DEHP) possesses the potential to interfere with the male reproductive endocrine system in mammals; however, its reproductive toxicity in male zebrafish and associated epigenetic studies have not been explored. In this study, three-month-old male zebrafish were exposed to environmentally relevant concentrations of DEHP (0, 10, 33 and 100 μg/L) for 3 months, and then the impact on the reproduction of males and the underlying mechanism were investigated. Histological testing showed that an exposure concentration of 100 μg/L DEHP significantly inhibited spermatogenesis, with an associated decline in capability to fertilize untreated oocytes...
November 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29146426/determination-of-phthalic-acid-esters-in-water-samples-using-core-shell-poly-dopamine-magnetic-nanoparticles-and-gas-chromatography-tandem-mass-spectrometry
#2
Javier González-Sálamo, Bárbara Socas-Rodríguez, Javier Hernández-Borges, Miguel Ángel Rodríguez-Delgado
In this work, the first application of core-shell poly(dopamine) magnetic nanoparticles as sorbent for the extraction of a group of eleven phthalic acid esters of interest (i.e. diethyl phthalate (DEP), dipropyl phthalate (DPP), dibutyl phthalate (DBP), bis-isopentyl phthalate (DIPP), bis-n-pentyl phthalate (DNPP), benzylbutyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di-(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP)) and one adipate (bis (2-ethylhexyl) adipate, DEHA) from different water samples (Milli-Q, mineral, tap, pond and waste water) is proposed...
November 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29145569/immune-system-an-emerging-player-in-mediating-effects-of-endocrine-disruptors-on-metabolic-health
#3
Amita Bansal, Jorge Henao Mejia, Rebecca A Simmons
The incidence of metabolic disorders like type 2 diabetes and obesity continue to increase. In addition to the well-known contributors such as food intake and sedentary lifestyle, recent research in the exposure science discipline provides new evidence that exposure to endocrine disrupting chemicals like bisphenol A and phthalates via multiple routes (food, drink and skin contact) also contribute to the increased risk of metabolic disorders. Endocrine disrupting chemicals (EDCs) can disrupt any aspect of hormone action...
November 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/29145094/a-mixture-of-five-endocrine-disrupting-chemicals-modulates-concentrations-of-bisphenol-a-and-estradiol-in-mice
#4
Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro
Most people in developed countries are exposed to multiple endocrine-disrupting synthetic chemicals. We previously showed that a single dose of triclosan, tetrabromobisphenol A (TBBPA), butyl paraben, propyl paraben, or di(2-ethylhexyl) phthalate elevated concentrations of bisphenol A (BPA) in mice. Here we investigated whether concurrent exposure to lower doses of these five chemicals could modulate concentrations of bisphenol A (BPA) or the natural estrogen, 17β-estradiol (E2). CF1 mice were injected subcutaneously with 0...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29145093/proteomic-profile-and-toxicity-pathway-analysis-in-zebrafish-embryos-exposed-to-bisphenol-a-and-di-n-butyl-phthalate-at-environmentally-relevant-levels
#5
Xing Dong, Xuchun Qiu, Shunlong Meng, Hai Xu, Xiangyang Wu, Ming Yang
Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are well-known endocrine-disrupting chemicals (EDCs) that have human health risks. Chronic exposure to BPA and DBP increases the occurrence of human disease. Despite the potential for exposure in embryonic development, the mechanism of action of BPA and DBP on vertebrate development and disease still remains unclear. In the present study, we identified proteins and protein networks that are perturbed by BPA and DBP during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to environmentally relevant levels of BPA (10 μg/L) and DBP (50 μg/L) for 96 h...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29145058/occurrence-distribution-and-ecological-risks-of-phthalate-esters-in-the-seawater-and-sediment-of-changjiang-river-estuary-and-its-adjacent-area
#6
Ze-Ming Zhang, Hong-Hai Zhang, Jing Zhang, Qian-Wen Wang, Gui-Peng Yang
A total of 133 seawater samples and 17 sediment samples were collected from 81 sampling sites in the Changjiang River Estuary and its adjacent area and were analyzed for 16 phthalate esters (PAEs). The Σ16 PAE concentrations in the seawater and sediment samples ranged from 180.3ng·L(-1) to 3421ng·L(-1) and from 0.48μg·g(-1) to 29.94μg·g(-1)dry weight (dw), respectively, with mean values of 943.6ng·L(-1) and 12.88μg·g(-1). The distribution of ∑16PAE concentrations in the water column showed that PAE concentrations in the bottom samples were higher than those in the surface samples (except the transect C located inside the Changjiang River Estuary), with the maxima appearing in the bottom layer at the offshore stations...
November 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29144988/di-2-ethylhexyl-phthalate-enhances-melanoma-tumor-growth-via-differential-effect-on-m1-and-m2-polarized-macrophages-in-mouse-model
#7
Jae-Wook Lee, Sojin Park, Hae-Kyoung Han, Myung Chan Gye, Eun-Yi Moon
Phthalates are widely used as plasticizers that influence sexual and reproductive development. Here, we investigated whether di-(2-ethylhexyl) phthalate (DEHP) affects macrophage polarization that are associated with tumor initiation and progression. No changes were observed in LPS- or ConA-stimulated in vitro spleen B or T cell proliferation for 48 h, respectively. In contrast, macrophage functions were inhibited in response to DEHP for 12 h as judged by LPS-induced H2O2 and NO production and zymosan A-mediated phagocytosis...
November 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29142003/disparities-in-environmental-exposures-to-endocrine-disrupting-chemicals-and-diabetes-risk-in-vulnerable-populations
#8
Daniel Ruiz, Marisol Becerra, Jyotsna S Jagai, Kerry Ard, Robert M Sargis
Burgeoning epidemiological, animal, and cellular data link environmental endocrine-disrupting chemicals (EDCs) to metabolic dysfunction. Disproportionate exposure to diabetes-associated EDCs may be an underappreciated contributor to disparities in metabolic disease risk. The burden of diabetes is not uniformly borne by American society; rather, this disease disproportionately affects certain populations, including African Americans, Latinos, and low-income individuals. The purpose of this study was to review the evidence linking unequal exposures to EDCs with racial, ethnic, and socioeconomic diabetes disparities in the U...
November 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29140336/whispering-gallery-modes-in-a-liquid-filled-hollow-glass-microsphere
#9
Shuangqiang Liu, Bojian Shi, Yan Wang, Lugui Cui, Jun Yang, Weimin Sun, Hanyang Li
We develop a hydrofluoric (HF) etching process to open a microhole on the hollow glass microsphere (HGM). The typical whispering gallery mode (WGM) resonance was observed by coupling the HGM with a tapered fiber. Dioctyl phthalate was filled into the HGM, and the resonance wavelength decreased at elevated temperatures. We analyzed the WGM resonance properties inside the liquid-filled HGM with a higher or lower refractive index in comparison to the HGM wall. Four different liquids were also injected into the HGM to investigate the influence of the thermo-optic coefficient on the temperature sensitivity...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29139118/di-2-ethylhexyl-phthalate-dehp-exposure-disturbs-lipid-metabolism-in-juvenile-yellow-catfish-tachysurus-fulvidraco
#10
F X Meng, M Li, M Z Song, L X Yuan, Y F Gong, Y X Qian, G Shi, R X Wang
This study was conducted to determine the mechanism by which di-2-ethylhexyl phthalate (DEHP) exposure influences lipid metabolism of juvenile yellow catfish Tachysurus fulvidraco. Fish were exposed to three DEHP concentrations (0, 0·1 and 0·5 mg l(-1) DEHP) for 8 weeks. Fatty acid synthase (FAS) activity significantly decreased with increasing DEHP concentrations, the highest value was in the Tween control group, whereas the lowest activities of carnitine palmitoyltransferase (CPT) and lipoprotein lipase (LPL) were in this group...
November 15, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29138622/antimicrobial-efficacy-of-penicillium-amestolkiae-elv609-extract-treated-cotton-fabric-for-diabetic-wound-care
#11
Nur Amiera Syuhada Binti Rozman, Nurhanis Syafiqah Binti Mohd Nor Hamin, Leong Chean Ring, Tan Wen Nee, Mahfuzah Binti Mustapha, Tong Woei Yenn
Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Foot ulceration and wound infection are major forms of disabilities arising from diabetic diseases. This study was aimed to develop a natural antimicrobial finishing on medical grade textile that meets American Association of Textiles Chemists and Colorists (AATCC) standard. The textile samples were finished with the ethanolic extract of Penicillium amestolkiae elv609, an endophytic fungus isolated from Orthosiphon stamineus Benth (common name: cat's whiskers)...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29137157/in-situ-synthesis-of-silver-nanoparticles-in-a-hydrogel-of-carboxymethyl-cellulose-with-phthalated-cashew-gum-as-a-promising-antibacterial-and-healing-agent
#12
Ana Karina Marques Fortes Lustosa, Antônia Carla de Jesus Oliveira, Patrick Veras Quelemes, Alexandra Plácido, Francilene Vieira da Silva, Irisdalva Sousa Oliveira, Miguel Peixoto de Almeida, Adriany das Graças Nascimento Amorim, Cristina Delerue-Matos, Rita de Cássia Meneses de Oliveira, Durcilene Alves da Silva, Peter Eaton, José Roberto de Souza de Almeida Leite
Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133889/oral-exposure-to-dibutyl-phthalate-exacerbates-chronic-lymphocytic-thyroiditis-through-oxidative-stress-in-female-wistar-rats
#13
Yang Wu, Jinquan Li, Biao Yan, Yuqing Zhu, Xudong Liu, Mingqing Chen, Dai Li, Ching-Chang Lee, Xu Yang, Ping Ma
Chronic lymphocytic thyroiditis (CLT) is a common autoimmune disorder. The possible pathogenic role and mechanism of dibutyl phthalate (DBP) in CLT is still controversial. Experiments were conducted after 35-days of oral exposure to the three concentrations of DBP or saline, and three immunizations with thyroglobulin (TG). Healthy female Wistar rats were randomly divided into ten exposure groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 mg/kg/d DBP, (D) 50 mg/kg/d DBP, (E) TG-immunized group, (F) TG- combined with 0...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131975/identification-of-urinary-biomarkers-of-exposure-to-di-2-propylheptyl-phthalate-using-high-resolution-mass-spectrometry-and-two-data-screening-approaches
#14
Chia-Lung Shih, Pao-Mei Liao, Jen-Yi Hsu, Yi-Ning Chung, Victor G Zgoda, Pao-Chi Liao
Di-(2-propylheptyl) phthalate (DPHP) is a plasticizer used in polyvinyl chloride and vinyl chloride copolymer that has been suggested to be a toxicant in rats and may affect human health. Because the use of DPHP is increasing, the general German population is being exposed to DPHP. Toxicant metabolism is important for human toxicant exposure assessments. To date, the knowledge regarding DPHP metabolism has been limited, and only four metabolites have been identified in human urine. Ultra-performance liquid chromatography was coupled with Orbitrap high-resolution mass spectrometry (MS) and two data-screening approaches-the signal mining algorithm with isotope tracing (SMAIT) and the mass defect filter (MDF)-for DPHP metabolite candidate discovery...
October 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29129023/pathomechanisms-of-contact-sensitization
#15
REVIEW
Philipp R Esser, Stefan F Martin
Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD...
November 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29128616/di-n-octylphthalate-acts-as-a-proliferative-agent-in-murine-cell-hepatocytes-by-regulating-the-levels-of-tgf-%C3%AE-and-pro-apoptotic-proteins
#16
Shelby Buckner, Allison Pruitt, Cecilia Thomas, Monisha Amin, Laurence Miller, Faith Wiley, Maria Eugenia Sabbatini
Di-n-octylphthalate (DNOP) is a phthalate used in the manufacturing of a wide variety of polyvinyl chloride-containing medical and consumer products. A study on chronic exposure to DNOP in rodents showed the development of pre-neoplastic hepatic lesions following exposure to a tumor initiator. The objective of this study was to identify the mechanisms by which DNOP leads to pre-neoplastic hepatic lesions. Mouse hepatocyte AML-12 and FL83B cells were treated with DNOP. The rate of cell proliferation was increased in treated cells in a concentration-dependent manner...
November 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29127870/concentrations-of-several-phthalates-contaminants-in-egyptian-bottled-water-effects-of-storage-conditions-and-estimate-of-human-exposure
#17
Ghada Zaki, Tamer Shoeib
The occurrence and concentrations of six common phthalates were investigated for the first time in bottled water locally produced in the Egyptian market. The compounds investigated were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), n-butyl benzyl phthalate (BBP), diethyl hexyl phthalate (DEHP), and Di-n-octyl phthalate (D-n-OP). A set of 108 bottled water samples from six different commercial brands of water bottled in transparent polyethylene terephthalate (PET) plastic bottles with high density polyethylene (HDPE) plastic caps were investigated...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127800/regulation-of-chemicals-in-children-s-products-how-u-s-and-eu-regulation-impacts-small-markets
#18
Maya Negev, Tamar Berman, Shay Reicher, Simona Balan, Anna Soehl, Shula Goulden, Ruti Ardi, Yaniv Shammai, Laura Hadar, Arlene Blum, Miriam L Diamond
Toys and children's products may contain trace metals and organic compounds that are potentially harmful to the health and development of infants and young children. Intergovernmental organizations and individual countries regulate chemicals in consumer products, but a coordinated international approach is lacking. This paper examines the implications of chemical regulation in children's products in large markets for a smaller market, namely Israel. We compared chemical regulations in children's products in the U...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29126512/what-is-an-endocrine-disruptor
#19
Claude Monneret
Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly man-made found in various materials. By interfering with the body's endocrine system, endocrine disruptors produce adverse developmental, reproductive, neurological, and immune effects in humans, abnormal growth patterns and neurodevelopmental delays in children. Thus, diethylstilbestrol (DES) a non-steroidal estrogen, which is regarded as a proof of concept, induces clear cell carcinoma among young women. EDCS may be found in plastic bottles and metal food cans (BPA), medical devices (phthalates), detergents, flame retardants (polybrominated diphenyl ethers), food (BPA), toys (phthalates), cosmetics and drugs (parabens), and pesticides (alkyl phenols such as nonylphenol)...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29122348/associations-of-urinary-phthalate-metabolites-with-residential-characteristics-lifestyles-and-dietary-habits-among-young-children-in-shanghai-china
#20
Chenxi Liao, Wei Liu, Jialing Zhang, Wenming Shi, Xueying Wang, Jiao Cai, Zhijun Zou, Rongchun Lu, Chanjuan Sun, Heng Wang, Chen Huang, Zhuohui Zhao
Exposure to household phthalates has been reported to have adverse effects on children's health. In this paper, we used phthalate metabolites in the first morning urine as indicators of household phthalate exposures and examined their associations with residential characteristics, lifestyles and dietary habits among young children. During 2013-2014, we collected morning urines from children aged 5-10years in Shanghai, China and obtained the related information about analyzed factors in this study by questionnaires...
November 6, 2017: Science of the Total Environment
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