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https://www.readbyqxmd.com/read/28339786/modelling-original-antigenic-sin-in-dengue-viral-infection
#1
Ryan Nikin-Beers, Stanca M Ciupe
Cross-reactive T cell responses induced by a primary dengue virus infection may contribute to increased disease severity following heterologous infections with a different virus serotype in a phenomenon known as the original antigenic sin. In this study, we developed and analyzed in-host models of T cell responses to primary and secondary dengue virus infections that considered the effect of T cell cross-reactivity in disease enhancement. We fitted the models to published patient data and showed that the overall infected cell killing is similar in dengue heterologous infections, resulting in dengue fever and dengue hemorrhagic fever...
February 27, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28334388/bacterial-endosymbionts-of-the-psyllid-cacopsylla-pyricola-hemiptera-psyllidae-in-the-pacific-northwestern-united-states
#2
W Rodney Cooper, Stephen F Garczynski, David R Horton, Thomas R Unruh, Elizabeth H Beers, W Shearer Peter, Richard J Hilton
Insects often have facultative associations with bacterial endosymbionts, which can alter the insects' susceptibility to parasitism, pathogens, plant defenses, and certain classes of insecticides. We collected pear psylla, Cacopsylla pyricola (Förster) (Hemiptera: Psyllidae), from pear orchards in Washington and Oregon, and surveyed them for the presence of bacterial endosymbionts. Adult psyllids were collected on multiple dates to allow us to assay specimens of both the summer ("summerform") and the overwintering ("winterform") morphotypes...
March 3, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28331216/porewater-salinity-reveals-past-lake-level-changes-in-lake-van-the-earth-s-largest-soda-lake
#3
Yama Tomonaga, Matthias S Brennwald, David M Livingstone, Olga Kwiecien, Marie-Ève Randlett, Mona Stockhecke, Katie Unwin, Flavio S Anselmetti, Jürg Beer, Gerald H Haug, Carsten J Schubert, Mike Sturm, Rolf Kipfer
In closed-basin lakes, sediment porewater salinity can potentially be used as a conservative tracer to reconstruct past fluctuations in lake level. However, until now, porewater salinity profiles did not allow quantitative estimates of past lake-level changes because, in contrast to the oceans, significant salinity changes (e.g., local concentration minima and maxima) had never been observed in lacustrine sediments. Here we show that the salinity measured in the sediment pore water of Lake Van (Turkey) allows straightforward reconstruction of two major transgressions and a major regression that occurred during the last 250 ka...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330932/respond-a-programme-to-prevent-secondary-falls-in-older-people-presenting-to-the-emergency-department-with-a-fall-protocol-for-an-economic-evaluation
#4
R T Morello, R L Morris, K D Hill, T P Haines, G Arendts, J Redfern, C D Etherton-Beer, J A Lowthian, C A Brand, D Liew, J J Watts, A L Barker
BACKGROUND: Falls remain common for community-dwelling older people and impose a substantial economic burden to the healthcare system. RESPOND is a novel falls prevention programme that aims to reduce secondary falls and fall injuries among older people who present to a hospital emergency department (ED) with a fall. The present protocol describes a prospective economic evaluation examining the incremental cost-effectiveness of the RESPOND programme, compared with usual care practice, from the Australian health system perspective...
April 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28330798/knee-osteoarthritis-degenerative-meniscal-lesion-and-osteonecrosis-of-the-knee-can-a-simple-gait-test-direct-us-to-a-better-clinical-diagnosis
#5
Ronen Debi, Avi Elbaz, Amit Mor, Gadi Kahn, Bezalel Peskin, Yiftah Beer, Gabriel Agar, Guy Morag, Ganit Segal
INTRODUCTION: The purpose of the current study was to compare the gait patterns in patients with three differing knee pathologies - knee osteoarthritis (OA), degenerative meniscal lesion (DML) and spontaneous osteonecrosis of the knee (SONK) and a group of healthy controls. HYPOTHESIS: A simple gait test will detect differences between different knee pathologies. MATERIAL AND METHODS: Forty-seven patients with bilateral knee OA, 47 patients with DML, 28 patients with SONK and 27 healthy controls were included in this analysis...
March 19, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28330761/quantification-of-4-methylimidazole-in-soft-drinks-sauces-and-vinegars-of-greek-market-using-two-liquid-chromatography-techniques
#6
Manolis N Tzatzarakis, Elena Vakonaki, Sofia Moti, Alegakis Athanasios, Christina Tsitsimpikou, Ioannis Tsakiris, Marina Goumenou, Alexander E Nosyrev, Apostolos K Rizos, Aristidis M Tsatsakis
The substance 4-methylimidazole (4-MEI) has raised several concerns regarding its toxicity to humans, although no harmonized classification has yet been decided. The regulatory limits for food products set by various authorities in Europe and the USA differ considerably. The purpose of the present study is to compare two liquid chromatography techniques in order to determine the levels of 4-MEI in food products from the Greek market and roughly estimate the possible exposure and relevant health risk for the consumers...
March 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28326803/when-is-an-alveolar-type-2-cell-an-alveolar-type-2-cell-a-conundrum-for-lung-stem-cell-biology-and-regenerative-medicine
#7
Michael F Beers, Yuben Moodley
Generating mature, differentiated, adult lung cells from pluripotent cells such as induced pluripotent cells (iPS) and embryonic stem cells (ES) offers the hope of both generating disease specific in vitro models and creating definitive and personalized therapies for a host of debilitating lung parenchymal and airway diseases. With the goal of advancing lung regenerative medicine, several groups have developed and reported on protocols utilizing either defined media, co-culture with mesenchymal components, or sequential treatments mimicking lung development, to obtain distal lung epithelial cells from stem cell precursors...
March 22, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28326173/a-systematic-review-of-occupational-exposure-to-coal-dust-and-the-risk-of-interstitial-lung-diseases
#8
REVIEW
Christiane Beer, Henrik A Kolstad, Klaus Søndergaard, Elisabeth Bendstrup, Dick Heederik, Karen E Olsen, Øyvind Omland, Edward Petsonk, Torben Sigsgaard, David L Sherson, Vivi Schlünssen
Objective: Exposure to coal dust can cause interstitial lung disease (ILD), but whether this is due to pure coal or to the contents of quartz in coal is less clear. Here, we systematically reviewed the relation between 'pure coal' and ILD. Methods: In a systematic review based on PRISMA criteria 2945 articles were identified. Strict eligibility criteria, which evaluated the 'pure coal effect', led to the inclusion of only nine studies. Results: Among these nine studies six studies indicated an independent effect of the non-quartz part of coal on the development and progression of ILD, two did not demonstrate an effect and one was inconclusive...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28323679/the-day-that-went-missing-a-first-person-account-of-transient-global-amnesia
#9
Trip Gabriel
In this vivid first-person case history, political reporter Trip Gabriel describes experiencing a classic episode of transient global amnesia. He was near the average target age of 61. Although no cause has been established for the syndrome, as with many other patients his episode appears to have been triggered by contact with water: He was racing a sailboat. While remaining alert and handling complex sailing maneuvers, he suddenly developed amnesia that left him with no recollection of finishing two races, returning to shore, drinking a beer with his friends, needing help finding his car, and not knowing where he was or where he lived...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28323494/associations-between-thematic-content-and-industry-self-regulation-code-violations-in-beer-advertising-broadcast-during-the-u-s-ncaa-basketball-tournament
#10
Jonathan K Noel, Ziming Xuan, Thomas F Babor
BACKGROUND: Beer marketing in the United States is controlled through self-regulation, whereby the beer industry has created a marketing code and enforces its use. We performed a thematic content analysis on beer ads broadcast during a U.S. college athletic event and determined which themes are associated with violations of a self-regulated alcohol marketing code. METHODS: 289 beer ads broadcast during the U.S. NCAA Men's and Women's 1999-2008 basketball tournaments were assessed for the presence of 23 thematic content areas...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28322692/peste-des-petits-ruminants-virus-in-vulnerable-wild-small-ruminants-iran-2014-2016
#11
Mahmoud Marashi, Siamak Masoudi, Majid Kharazian Moghadam, Hossein Modirrousta, Mahyar Marashi, Masoumeh Parvizifar, Majid Dargi, Mahyar Saljooghian, Farbod Homan, Bernd Hoffmann, Claudia Schulz, Elke Starick, Martin Beer, Sasan Fereidouni
In 2014-2016, >1,000 wild goats and sheep in 4 northern and central provinces of Iran died from peste des petits ruminants virus (PPRV) infection. Partial nucleoprotein sequencing of PPRV from 3 animals showed a close relationship to lineage 4 strains from China. Control measures are needed to preserve vulnerable ruminant populations.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322487/methodology-for-senior-proof-guidelines-a-practice-example-from-the-netherlands
#12
Barbara C van Munster, Johanna E A Portielje, Andrea B Maier, Arend J Arends, Johannes J A de Beer
RATIONALE, AIMS AND OBJECTIVES: Evidence-based guidelines constitute a foundation for medical decision making. It is often unclear whether recommendations in general guidelines also apply to older people. This study aimed to develop a methodology to increase the focus on older people in the development of guidelines. METHODS: The methodology distinguishes 4 groups of older people: (1) relatively healthy older people; (2) older people with 1 additional specific (interfering) comorbid condition; (3) older people with multimorbidity; and (4) vulnerable older people...
March 21, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28322077/enteral-nutrition-increases-interstitial-brain-glucose-levels-in-poor-grade-subarachnoid-hemorrhage-patients
#13
Mario Kofler, Alois J Schiefecker, Ronny Beer, Maxime Gaasch, Paul Rhomberg, John Stover, Bettina Pfausler, Claudius Thomé, Erich Schmutzhard, Raimund Helbok
Low brain tissue glucose levels after acute brain injury are associated with poor outcome. Whether enteral nutrition (EN) reliably increases cerebral glucose levels remains unclear. In this retrospective analysis of prospectively collected observational data, we investigate the effect of EN on brain metabolism in 17 poor-grade subarachnoid hemorrhage (SAH) patients undergoing cerebral microdialysis (CMD) monitoring. CMD-values were obtained hourly. A nutritional intervention was defined as the clinical routine administration of EN without supplemental parenteral nutrition...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28317952/selective-perrhenate-recognition-in-pure-water-by-halogen-bonding-and-hydrogen-bonding-alpha-cyclodextrin-based-receptors
#14
Stuart P Cornes, Mark R Sambrook, Paul D Beer
Alpha-cyclodextrin based anion receptors functionalised with pendant arms containing halogen and hydrogen bond donor motifs display selective association of perrhenate in aqueous media at neutral pH. NMR and ITC anion binding investigations reveal the halogen bonding receptor to be the superior host.
March 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28317540/endophytic-botryosphaeriaceae-including-five-new-species-associated-with-mangrove-trees-in-south-africa
#15
J Alexander Osorio, Casparus J Crous, Z Wilhelm de Beer, Michael J Wingfield, Jolanda Roux
Little is known regarding the fungi, especially fungal pathogens, associated with mangroves in Africa. This includes fungi in the Botryosphaeriaceae that comprise numerous opportunistic, stress-associated pathogens often associated with trees affected by environmental and anthropogenically generated stresses, such as those affecting mangroves. We investigated the occurrence of endophytic Botryosphaeriaceae along the entire distribution of mangroves in South Africa. Asymptomatic branches were collected from ten localities and six mangrove species...
April 2017: Fungal Biology
https://www.readbyqxmd.com/read/28317512/alcohol-industry-sponsorship-of-university-student-sports-clubs-in-brazil
#16
Ilana Pinsky, Ana Regina Noto, Maria Carolina Botéquio de Moraes, Elaine Lucas Dos Santos, Robert Sparks, Kerry O'Brien
OBJECTIVE: The university sport environment represents an important target for alcohol industry marketing. This study investigated the nature of relationships between the alcohol industry and university student sports clubs (USSCs). METHOD: Semi-structured interviews were conducted with board members from 60 active USSCs in the city of São Paulo, Brazil. Interviews were transcribed and subjected to content analysis using NVivo10. RESULTS: All invited USSCs participated in the study...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28314869/-operative-treatment-of-terrible-triad-injury-of-the-elbow-open-reduction-and-internal-fixation
#17
R Babst, C Schraner, F J P Beeres
AIM OF SURGERY: Reconstruction of the most important ligamentous and osseus structures of the elbow after terrible triad injury via the radial head to the lateral collateral ligament complex (LCL) and if necessary beginning at the coronoid process. The aim is a stable concentrically guided elbow with early functional follow-up treatment. The approach depends on the intraoperatively tested stability. INDICATIONS: Osteoligamentous terrible triad injury pattern with or without subluxation position following reduction and temporary immobilization...
March 17, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28314560/the-epidemiology-of-invasive-meningococcal-disease-in-eu-eea-countries-2004-2014
#18
Robert Whittaker, Joana Gomes Dias, Miriam Ramliden, Csaba Ködmön, Assimoula Economopoulou, Netta Beer, Lucia Pastore Celentano
BACKGROUND: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compare country trends by the period of meningococcal C conjugate (MCC) vaccine introduction. METHODS: We analysed IMD surveillance data by age, gender, serogroup, country and outcome...
March 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28314404/the-role-of-robotic-surgery-in-sinonasal-and-ventral-skull-base-malignancy
#19
REVIEW
Ralph Abi Hachem, Sanjeet Rangarajan, Andre Beer-Furlan, Daniel Prevedello, Enver Ozer, Ricardo L Carrau
Over the past decade, robotic surgery has gained wide popularity, making a significant impact on multiple surgical specialties. In the head and neck arena, transoral robotic surgery has proven to be safe and associated with acceptable oncological and superior functional outcomes for surgery of the oropharynx, hypopharynx, supraglottis, and glottis; thus, changing the paradigm for the management of tumors in these anatomic locations. Robotic surgery of the ventral skull base is at an early stage of development...
April 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28306730/evaluation-of-radiation-sensitivity-and-mating-performance-of-glossina-brevipalpis-males
#20
Chantel J de Beer, Percy Moyaba, Solomon N B Boikanyo, Daphney Majatladi, Hanano Yamada, Gert J Venter, Marc J B Vreysen
BACKGROUND: Area-wide integrated pest management strategies that include a sterile insect technique component have been successfully used to eradicate tsetse fly populations in the past. To ensure the success of the sterile insect technique, the released males must be adequately sterile and be able to compete with their native counterparts in the wild. METHODOLOGY/PRINCIPAL FINDINGS: In the present study the radiation sensitivity of colonised Glossina brevipalpis Newstead (Diptera; Glossinidae) males, treated either as adults or pupae, was assessed...
March 17, 2017: PLoS Neglected Tropical Diseases
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