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https://www.readbyqxmd.com/read/28549709/ct-guided-bone-biopsies-in-metastatic-castration-resistant-prostate-cancer-factors-predictive-of-maximum-tumor-yield
#1
Michael G Holmes, Erik Foss, Gabby Joseph, Adam Foye, Brooke Beckett, Daria Motamedi, Jack Youngren, George V Thomas, Jiaoti Huang, Rahul Aggarwal, Joshi J Alumkal, Tomasz M Beer, Eric J Small, Thomas M Link
PURPOSE: To evaluate the success rate of CT-guided bone biopsies in metastatic castration-resistant prostate cancer (mCRPC) and to investigate associated technical, imaging, and clinical parameters affecting diagnostic yields. MATERIALS AND METHODS: Eighty CT-guided bone biopsy specimens were obtained from 72 men (median age, 68 y; range, 49-89 y) enrolled in a multicenter trial to identify mechanisms of resistance in mCRPC. Successful biopsy was determined by histologic confirmation of tumor cells and successful isolation of RNA for molecular analysis...
May 24, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28547675/complications-following-proximal-femoral-locking-compression-plating-in-unstable-proximal-femur-fractures-medium-term-follow-up
#2
Sandro Hodel, Frank J P Beeres, Reto Babst, Björn-Christian Link
PURPOSE: To assess the outcome in patients treated with proximal femoral locking compression plate (PF-LCP 4.5/5.0, Synthes(©)) for unstable inter- and subtrochanteric femoral fractures. METHODS: A retrospective analysis of 16 patients with proximal femur fractures (AO: 31A2: n = 5/32.3%; 31-A3: n = 10/62.5%; 32B1: n = 1/6.3%) treated with a PF-LCP at a Level 1 trauma centre between 2011 and 2015 was conducted. RESULTS: Sixteen patients were available for follow-up with a mean follow-up time of 14 months (range 4-29)...
May 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28547651/photoplethysmography-for-blood-volumes-and-oxygenation-changes-during-intermittent-vascular-occlusions
#3
T Y Abay, P A Kyriacou
Photoplethysmography (PPG) is an optical technique that measures blood volume variations. The main application of dual-wavelength PPG is pulse oximetry, in which the arterial oxygen saturation (SpO[Formula: see text]) is calculated noninvasively. However, the PPG waveform contains other significant physiological information that can be used in conjunction to SpO[Formula: see text] for the assessment of oxygenation and blood volumes changes. This paper investigates the use of near infrared spectroscopy (NIRS) processing techniques for extracting relative concentration changes of oxygenated ([Formula: see text]HbO[Formula: see text]), reduced ([Formula: see text]HHb) and total haemoglobin ([Formula: see text]tHb) from dual-wavelength PPG signals during intermittent pressure-increasing vascular occlusions...
May 25, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28546643/decomposition-of-regional-convergence-in-population-aging-across-europe
#4
Ilya Kashnitsky, Joop de Beer, Leo van Wissen
In the face of rapidly aging population, decreasing regional inequalities in population composition is one of the regional cohesion goals of the European Union. To our knowledge, no explicit quantification of the changes in regional population aging differentiation exist. We investigate how regional differences in population aging developed over the last decade and how they are likely to evolve in the coming three decades, and we examine how demographic components of population growth contribute to the process...
2017: Genus
https://www.readbyqxmd.com/read/28546612/mouth-cancer-craft-beer-craze
#5
J B White
No abstract text is available yet for this article.
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28545260/thermostabilization-of-the-uronate-dehydrogenase-from-agrobacterium-tumefaciens-by-semi-rational-design
#6
Teresa Roth, Barbara Beer, André Pick, Volker Sieber
Aldaric acids represent biobased 'top value-added chemicals' that have the potential to substitute petroleum-derived chemicals. Until today they are mostly produced from corresponding aldoses using strong chemical oxidizing agents. An environmentally friendly and more selective process could be achieved by using natural resources such as seaweed or pectin as raw material. These contain large amounts of uronic acids as major constituents such as glucuronic acid and galacturonic acid which can be converted into the corresponding aldaric acids via an enzyme-based oxidation using uronate dehydrogenase (Udh)...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28544582/evaluation-by-medical-students-of-the-educational-value-of-multi-material-and-multi-colored-three-dimensional-printed-models-of-the-upper-limb-for-anatomical-education
#7
Sreenivasulu Reddy Mogali, Wai Yee Yeong, Heang Kuan Joel Tan, Gerald Jit Shen Tan, Peter H Abrahams, Nabil Zary, Naomi Low-Beer, Michael Alan Ferenczi
For centuries, cadaveric material has been the cornerstone of anatomical education. For reasons of changes in curriculum emphasis, cost, availability, expertise, and ethical concerns, several medical schools have replaced wet cadaveric specimens with plastinated prosections, plastic models, imaging, and digital models. Discussions about the qualities and limitations of these alternative teaching resources are on-going. We hypothesize that three-dimensional printed (3DP) models can replace or indeed enhance existing resources for anatomical education...
May 19, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28542003/providing-choice-in-exercise-influences-food-intake-at-the-subsequent-meal
#8
Natalya J Beer, James A Dimmock, Ben Jackson, Kym J Guelfi
The benefits of regular exercise for health are well established; however, certain behaviors following exercise, such as unhealthy or excessive food consumption, can counteract some of these benefits. PURPOSE: To investigate the effect of autonomy support (through the provision of choice) in exercise - relative to a no-choice condition with matched energy expenditure - on appetite and subsequent energy intake. METHODS: Fifty-eight men and women (body mass index: 22...
May 23, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28540648/impact-of-2015-update-to-the-beers-criteria-on-estimates-of-prevalence-and-costs-associated-with-potentially-inappropriate-use-of-antimuscarinics-for-overactive-bladder
#9
Brandon T Suehs, Cralen Davis, Daniel B Ng, Katherine Gooch
BACKGROUND: Research has demonstrated that the use of potentially inappropriate medication (PIM) is highly prevalent among older individuals and may lead to increased healthcare costs, adverse drug reactions, hospitalizations, and mortality. OBJECTIVES: The purpose of this study was to examine the impact of the 2015 updates to the Beers Criteria on estimates of prevalence and cost associated with potentially inappropriate use of antimuscarinic medications indicated for treatment of overactive bladder (OAB)...
May 24, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28540569/altered-purinergic-signaling-in-uridine-adenosine-tetraphosphate-induced-coronary-relaxation-in-swine-with-metabolic-derangement
#10
Zhichao Zhou, Oana Sorop, Vincent J de Beer, Ilkka Heinonen, Caroline Cheng, A H Jan Danser, Dirk J Duncker, Daphne Merkus
We previously demonstrated that uridine adenosine tetraphosphate (Up4A) induces potent and partially endothelium-dependent relaxation in the healthy porcine coronary microvasculature. We subsequently showed that Up4A-induced porcine coronary relaxation was impaired via downregulation of P1 receptors after myocardial infarction. In view of the deleterious effect of metabolic derangement on vascular function, we hypothesized that the coronary vasodilator response to Up4A is impaired in metabolic derangement, and that the involvement of purinergic receptor subtypes and endothelium-derived vasoactive factors (EDVFs) is altered...
May 24, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28533609/gait-abnormalities-in-patients-with-chronic-ankle-instability-can-improve-following-a-non-invasive-biomechanical-therapy-a-retrospective-analysis
#11
Shay Tenenbaum, Ofir Chechik, Jason Bariteau, Nathan Bruck, Yiftah Beer, Mazen Falah, Ganit Segal, Amit Mor, Avi Elbaz
[Purpose] The purpose of this study was to evaluate the changes in gait patterns and clinical outcomes of patients with chronic ankle instability (CAI) following treatment with a home-based non-invasive biomechanical device. [Subjects and Methods] Thirty-three patients with CAI were compared with 43 healthy controls. Patients underwent a spatiotemporal gait assessment before and three months following treatment. Clinical evaluation was recorded with SF-36 Health Survey and the Foot and Ankle Outcome Score (FAOS)...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28530752/active-metal-template-synthesis-of-a-neutral-indolocarbazole-containing-2-rotaxane-host-system-for-selective-oxoanion-recognition
#12
Asha Brown, Thomas Lang, Kathleen M Mullen, Paul D Beer
An active metal template strategy was used to synthesise a neutral indolocarbazole containing [2]rotaxane anion host system. (1)H NMR anion binding investigations reveal that the [2]rotaxane recognises a range of monoanions in acetone-d5 : D2O 95 : 5 with an unusual interlocked host selectivity for acetate and dihydrogenphosphate oxoanions over halides. The rotaxane displays an overall selectivity for the sulfate dianion, favouring a 2 : 1 host : guest binding stoichiometry at low sulfate concentration and a 1 : 1 stoichiometry in the presence of excess sulfate...
May 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28530592/thermal-stability-of-the-functional-ingredients-glucosylated-benzophenones-and-xanthones-of-honeybush-cyclopia-genistoides-in-an-aqueous-model-solution
#13
Theresa Beelders, Dalene de Beer, Daneel Ferreira, Martin Kidd, Elizabeth Joubert
Thermal stability of the benzophenones, 3-β-d-glucopyranosyl-4-β-d-glucopyranosyloxyiriflophenone (1), 3-β-d-glucopyranosylmaclurin (2) and 3-β-d-glucopyranosyliriflophenone (3), and the xanthones, mangiferin (4) and isomangiferin (5), was assessed separately in an aqueous model solution (pH 5) to delineate their major degradation products and mechanism(s). Degradation followed first-order reaction kinetics and the temperature-dependence of the respective reaction rate constants complied with the Arrhenius equation...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530347/-the-need-for-help-of-family-caregivers-of-persons-with-mental-illness-in-a-unique-service-for-families-at-the-beer-sheva-mental-health-center
#14
Anat Shalev, Ron Shor
BACKGROUND: Limited research attention has been given to the needs of family caregivers of persons with mental illness in psychiatric hospitals despite the stressors and difficulties they experience. In light of the recognition of the significance of helping family caregivers, a new model of consultation and support centers for family caregivers, called Meital, has been developed. OBJECTIVES: To examine the needs of family caregivers who receive help in Meital, at the Beer Sheva Mental Health Center...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530346/-seeds-of-mindfulness-in-the-desert-preliminary-results-from-a-clinical-trial-in-the-mindfulness-clinic-mental-health-center-beer-sheva
#15
Lee Tibi Cohen, Keren Reiner Noy, Ayelet Shmulevich, Oded Arbel
INTRODUCTION: Mindfulness-based therapies are rooted in the Buddhist tradition, and promote cultivation of qualities such as open awareness, acceptance and compassion. While various studies have demonstrated the efficacy of integrating mindfulness in therapeutic practice for people suffering from clinical conditions such as depression and anxiety as well as the non-clinical population, this was rarely replicated in Israel. In the Mindfulness Clinic, located in the Mental Health Center, Beer Sheva, mindfulness workshops are now available for diverse populations dealing with various challenges such as daily stress, chronic pain, and depression...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530334/-from-theory-to-practice-implementing-the-bio-psycho-social-model-in-clinical-and-research-activities-in-the-beer-sheva-mental-health-center
#16
Hagit Cohen, Doron Todder
The Beer Sheva Mental Health Center is the second largest mental health hospital in Israel and provides acute and chronic in-patient services for the entire population of the Southern District of Israel, from Ashdod to Eilat (about 1.2 million people) from adolescence to the elderly. The outpatient services include a variety of regional specialty services such as bipolar, eating disorders, anxiety, neuromodulation, gender-oriented, attention deficit hyperactivity disorder, sleep, dual diagnosis, geronto-psychiatry and post-traumatic stress disorder clinics and various rehabilitation day-care services...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530074/-patellofemoral-instability-anatomy-clinical-evaluation-imaging-and-treatment
#17
REVIEW
Noam Shohat, Dror Lindner, Iftach Beer, Gabriel Agar
Patellofemoral instability is a complex anatomical phenomena that requires deep understanding. The cause for instability could be a result of an anatomical defect or a soft tissue pathology. A thorough patient history, physical examination and imaging are paramount for a correct diagnosis and for deciding on the correct treatment. The proper treatment is often debatable. Conservative treatment is suitable for acute dislocation but has a high failure rate in chronic instability, which usually necessitates surgical treatment...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28527950/the-building-blocks-of-drinking-experience-across-men-and-women-a-case-study-with-craft-and-industrial-beers
#18
Carlos Gómez-Corona, Héctor B Escalona-Buendía, Sylvie Chollet, Dominique Valentin
In today's market, every product seems to be marked by the label of "experience". It is expected that successful products give the consumer "extraordinary experiences". The research in consumption experience is growing, but much work still needs to be done to understand the food and beverage experience. A qualitative study was conducted using contextual focus groups to explore the building blocks of consumers' drinking experience of industrial and craft beers. The results show that drinking experience is shaped by our cognitive, sensory or affective systems, especially during the core consumption experience...
May 18, 2017: Appetite
https://www.readbyqxmd.com/read/28526914/finite-element-method-simulating-temperature-distribution-in-skin-induced-by-980-nm-pulsed-laser-based-on-pain-stimulation
#19
Han Wang, Xiao-Xi Dong, Ji-Chun Yang, He Huang, Ying-Xin Li, Hai-Xia Zhang
For predicting the temperature distribution within skin tissue in 980-nm laser-evoked potentials (LEPs) experiments, a five-layer finite element model (FEM-5) was constructed based on Pennes bio-heat conduction equation and the Lambert-Beer law. The prediction results of the FEM-5 model were verified by ex vivo pig skin and in vivo rat experiments. Thirty ex vivo pig skin samples were used to verify the temperature distribution predicted by the model. The output energy of the laser was 1.8, 3, and 4.4 J. The laser spot radius was 1 mm...
May 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28521699/food-and-gastroesophageal-reflux-disease
#20
Teodora Surdea-Blaga, Dana E Negrutiu, Mariana Palage, Dan L Dumitrascu
Gastroesophageal reflux disease is a chronic condition with a high prevalence in western countries. Transient lower esophageal sphincter relaxation episodes and a decreased lower esophageal sphincter pressure are the main mechanisms involved. Currently used drugs are efficient on reflux symptoms, but only as long as they are administered, because they do not modify the reflux barrier. Certain nutrients or foods are generally considered to increase the frequency of gastroesophageal reflux symptoms, therefore physicians recommend changes in diet and some patients avoid bothering foods...
May 15, 2017: Current Medicinal Chemistry
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