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https://www.readbyqxmd.com/read/28227683/artsens-%C3%A2-mobile-a-portable-image-free-platform-for-automated-evaluation-of-vascular-stiffness
#1
Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, T Aryasree, Mohanasankar Sivaprakasam, Jayaraj Joseph, Malay Ilesh Shah
Vascular stiffness is a key physiological marker significant in screening and early diagnosis of vascular disease. However, state of art techniques for vascular stiffness evaluation are not suited for field deployment. We present ARTSENS(®) Mobile, a portable, image-free ultrasound technology platform for automated evaluation of carotid artery stiffness, amenable for field deployment. The technology utilises a single element ultrasound transducer operated in pulse echo modality to investigate arterial wall dynamics, assisted by intelligent algorithms for wall identification and motion tracking to completely automate the measurement...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227173/attractor-shape-descriptors-for-balance-impairment-assessment-in-parkinson-s-disease
#2
Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga, Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga, Narayanan Krishnamurthi, Anirudh Som, Pavan Turaga
In this paper, we propose a computational framework using high-dimensional shape descriptors of reconstructed attractors of center-of-pressure (CoP) tracings collected from subjects with Parkinson's disease while performing dynamical posture shifts, to quantitatively assess balance impairment. Using a dataset collected from 60 subjects, we demonstrated that the proposed method outperforms traditional methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223066/audiological-findings-in-children-with-mucopolysaccharidoses-type-i-iv
#3
María F Vargas-Gamarra, Carlos de Paula-Vernetta, Isidro Vitoria Miñana, Isabel Ibañez-Alcañiz, Laura Cavallé-Garrido, Agustín Alamar-Velazquez
OBJECTIVE: The aim of our study is to reflect hearing impairment of 23children diagnosed with mucopolysaccharidosis (MPS) typeI, II, III and IV. METHODS: Retrospective study of the clinical, audiological and treatment (medical vs surgical) findings of 23children diagnosed with MPS typeI, II, III or IV followed at a Tertiary Referral Hospital between 1997 and 2015. RESULTS: Six cases of MPSI, 8 of MPSII, 4 of MPSIII and 5 of MPSIV were reviewed...
February 18, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28214122/anaerobic-co-digestion-of-recalcitrant-agricultural-wastes-characterizing-of-biochemical-parameters-of-digestate-and-its-impacts-on-soil-ecosystem
#4
Adele Muscolo, Giovanna Settineri, Teresa Papalia, Emilio Attinà, Carmelo Basile, Maria Rosaria Panuccio
Anaerobic digestion (AD) of organic wastes is a promising alternative to landfilling for reducing Greenhouse Gas Emission (GHG) and it is encouraged by current regulation in Europe. Biogas-AD produced, represents a useful source of green energy, while its by-product (digestate) is a waste, that needs to be safely disposal. The sustainability of anaerobic digestion plants partly depends on the management of their digestion residues. This study has been focused on the environmental and economic benefits of co-digest recalcitrant agricultural wastes such olive wastes and citrus pulp, in combination with livestock wastes, straw and cheese whey for biogas production...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28211067/bipolar-lead-misplacement-contriving-an-electrocardiographic-pseudoinfarct
#5
Sumit Som, Perry Fisher, Paul Schweitzer
Electrocardiograph machines and clinicians can recognize many common lead misplacements. However, errors in arrangement of bipolar leads potentially create the unique predicament of pseudoinfarct ECG patterns. This article is protected by copyright. All rights reserved.
February 17, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28209905/diagnostic-value-of-18-f-fdg-pet-ct-versus-mri-in-the-setting-of-antibody-specific-autoimmune-encephalitis
#6
Lilja B Solnes, Krystyna M Jones, Steven P Rowe, Puskar Pattanayak, Abhinav Nalluri, Arun Venkatesan, John C Probasco, Mehrbod Som Javadi
Introduction: Diagnosis of autoimmune encephalitis presents some challenges in the clinical setting due to varied clinical presentations and delay in obtaining antibody panel results. We examined the role of neuroimaging in the setting of autoimmune encephalitides comparing the utility (18)F-FDG PET/CT versus conventional brain imaging with MRI. Methods: A retrospective study was performed assessing the positivity rate of MRI versus (18)F-FDG PET/CT during the initial work-up of 23 patients proven to have antibody positive autoimmune encephalitis...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#7
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28185568/identification-of-expression-patterns-in-the-progression-of-disease-stages-by-integration-of-transcriptomic-data
#8
Sara Aibar, Maria Abaigar, Francisco Jose Campos-Laborie, Jose Manuel Sánchez-Santos, Jesus M Hernandez-Rivas, Javier De Las Rivas
BACKGROUND: In the study of complex diseases using genome-wide expression data from clinical samples, a difficult case is the identification and mapping of the gene signatures associated to the stages that occur in the progression of a disease. The stages usually correspond to different subtypes or classes of the disease, and the difficulty to identify them often comes from patient heterogeneity and sample variability that can hide the biomedical relevant changes that characterize each stage, making standard differential analysis inadequate or inefficient...
November 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28185545/mirnatip-a-som-based-mirna-target-interactions-predictor
#9
Antonino Fiannaca, Massimo La Rosa, Laura La Paglia, Riccardo Rizzo, Alfonso Urso
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA sequences with regulatory functions to post-transcriptional level for several biological processes, such as cell disease progression and metastasis. MiRNAs interact with target messenger RNA (mRNA) genes by base pairing. Experimental identification of miRNA target is one of the major challenges in cancer biology because miRNAs can act as tumour suppressors or oncogenes by targeting different type of targets. The use of machine learning methods for the prediction of the target genes is considered a valid support to investigate miRNA functions and to guide related wet-lab experiments...
September 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28183423/recurrent-early-prosthetic-valve-endocarditis-caused-by-streptococcus-dysgalactiae-subspecies-equisimilis
#10
Sumit Som, Tatyana Danilov, John Puskas, Dennis Finkielstein
No abstract text is available yet for this article.
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28181481/dpath-software-reveals-hierarchical-haemato-endothelial-lineages-of-etv2-progenitors-based-on-single-cell-transcriptome-analysis
#11
Wuming Gong, Tara L Rasmussen, Bhairab N Singh, Naoko Koyano-Nakagawa, Wei Pan, Daniel J Garry
Developmental, stem cell and cancer biologists are interested in the molecular definition of cellular differentiation. Although single-cell RNA sequencing represents a transformational advance for global gene analyses, novel obstacles have emerged, including the computational management of dropout events, the reconstruction of biological pathways and the isolation of target cell populations. We develop an algorithm named dpath that applies the concept of metagene entropy and allows the ranking of cells based on their differentiation potential...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28160641/contribution-of-glomalin-to-dissolve-organic-carbon-under-different-land-uses-and-seasonality-in-dry-tropics
#12
Ashutosh Kumar Singh, Apurva Rai, Vivek Pandey, Nandita Singh
Glomalin related soil protein (GRSP) is a hydrophobic glycoprotein that is significant for soil organic carbon (SOC) persistence and sequestration, owing to its large contribution to SOC pool and long turnover time. However, the contribution of GRSP to dissolve OC (DOC) leach from soil is not yet comprehensively explored, though it could have implication in understanding SOC dynamics. We, therefore, aim to measure the contribution of GRSP to DOC, in a range of land uses and climatic seasons in the dry tropical ecosystem...
February 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28160587/use-of-self-organizing-maps-for-analyzing-the-behavior-of-canines-displaced-towards-midline-under-interceptive-treatment
#13
V Gandía-Aguiló, R Cibrián, E Soria, A-J Serrano, L Aguiló, V Paredes, J-L Gandía
BACKGROUND: Displaced maxillary permanent canine is one of the more frequent findings in canine eruption process and it's easy to be outlined and early diagnosed by means of x-ray images. Late diagnosis frequently needs surgery to rescue the impacted permanent canine. In many cases, interceptive treatment to redirect canine eruption is needed. However, some patients treated by interceptive means end up requiring fenestration to orthodontically guide the canine to its normal occlusal position...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28142125/potential-role-of-compost-and-green-manure-amendment-to-mitigate-soil-ghgs-emissions-in-mediterranean-drip-irrigated-maize-production-systems
#14
Annachiara Forte, Massimo Fagnano, Angelo Fierro
Organic fertilization can preserve soil organic matter (SOM) and is foreseen as an effective strategy to reduce green house gases (GHGs) emissions in agriculture. However, its effectiveness needs to be clarified under specific climate, crop management and soil characteristics. A field experiment was carried out in a Mediterranean drip irrigated maize system to assess the pattern of soil CO2 and N2O fluxes in response to the replacement of a typical bare fallow-maize cycle under urea fertilization (130 kg N ha(-1) y(-1)) (CONV) with: (i) bare fallow-maize cycles under two doses of compost (COM1 and COM2, 130 and 260 kg N ha(-1) y(-1), respectively) and (ii) a vetch-maize cycle, with vetch incorporation as green manure (130 kg N ha(-1) y(-1)) (GMAN)...
January 28, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28137611/analgesic-effect-of-dimethyl-trisulfide-in-mice-is-mediated-by-trpa1-and-sst4-receptors
#15
Gábor Pozsgai, Maja Payrits, Éva Sághy, Réka Sebestyén-Bátai, Elise Steen, Éva Szőke, Zoltán Sándor, Margit Solymár, András Garami, Péter Orvos, László Tálosi, Zsuzsanna Helyes, Erika Pintér
TRPA1 receptors are calcium-permeable ligand-gated channels expressed in primary sensory neurons and involved in inflammation and pain. Activation of these neurons might have analgesic effect. Suggested mechanism of analgesic effect mediated by TRPA1 activation is the release of somatostatin (SOM) and its action on sst4 receptors. In the present study analgesic effect of TRPA1 activation on primary sensory neurons by organic trisulfide compound dimethyl trisulfide (DMTS) presumably leading to SOM release was investigated...
January 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28124834/hybrid-network-model-for-deep-learning-of-chemical-data-application-to-antimicrobial-peptides
#16
Petra Schneider, Alex T Müller, Gisela Gabernet, Alexander L Button, Gernot Posselt, Silja Wessler, Jan A Hiss, Gisbert Schneider
We present a "deep" network architecture for chemical data analysis and classification together with a prospective proof-of-concept application. The model features a self-organizing map (SOM) as the input layer of a feedforward neural network. The SOM converts molecular descriptors to a two-dimensional image for further processing. We implemented lateral neuron inhibition for contrast enhancement. The model achieved improved classification accuracy and predictive robustness compared to feedforward network classifiers lacking the SOM layer...
January 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28118421/association-between-chronic-tension-type-headache-coexistent-with-chronic-temporomandibular-disorder-pain-and-limitations-in-physical-and-emotional-functioning-a-case-control-study
#17
Rüdiger Emshoff, Felix Bertram, Dagmar Schnabl, Iris Emshoff
AIMS: To assess the association between chronic tension-type headache coexistent with chronic temporomandibular disorder (TMD) pain and severe limitations in physical and emotional functioning. METHODS: Sample size estimation was used to determine that this case-control study should include 126 subjects. Subjects suffering from chronic TMD who were aged between 18 and 68 were recruited in routine clinical practice. Of the 126 included subjects, 63 had TMD pain associated with chronic tension-type headache (cases) and 63 had TMD pain without a history of tension-type headache (controls)...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28117439/a-competitive-inhibitory-circuit-for-selection-of-active-and-passive-fear-responses
#18
Jonathan P Fadok, Sabine Krabbe, Milica Markovic, Julien Courtin, Chun Xu, Lema Massi, Paolo Botta, Kristine Bylund, Christian Müller, Aleksandar Kovacevic, Philip Tovote, Andreas Lüthi
When faced with threat, the survival of an organism is contingent upon the selection of appropriate active or passive behavioural responses. Freezing is an evolutionarily conserved passive fear response that has been used extensively to study the neuronal mechanisms of fear and fear conditioning in rodents. However, rodents also exhibit active responses such as flight under natural conditions. The central amygdala (CEA) is a forebrain structure vital for the acquisition and expression of conditioned fear responses, and the role of specific neuronal sub-populations of the CEA in freezing behaviour is well-established...
January 25, 2017: Nature
https://www.readbyqxmd.com/read/28112735/nicotine-reverses-hypofrontality-in-animal-models-of-addiction-and-schizophrenia
#19
Fani Koukouli, Marie Rooy, Dimitrios Tziotis, Kurt A Sailor, Heidi C O'Neill, Josien Levenga, Mirko Witte, Michael Nilges, Jean-Pierre Changeux, Charles A Hoeffer, Jerry A Stitzel, Boris S Gutkin, David A DiGregorio, Uwe Maskos
The prefrontal cortex (PFC) underlies higher cognitive processes that are modulated by nicotinic acetylcholine receptor (nAChR) activation by cholinergic inputs. PFC spontaneous default activity is altered in neuropsychiatric disorders, including schizophrenia-a disorder that can be accompanied by heavy smoking. Recently, genome-wide association studies (GWAS) identified single-nucleotide polymorphisms (SNPs) in the human CHRNA5 gene, encoding the α5 nAChR subunit, that increase the risks for both smoking and schizophrenia...
January 23, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28102843/il-17-mediated-mitochondrial-dysfunction-impairs-apoptosis-in-rheumatoid-arthritis-synovial-fibroblasts-through-activation-of-autophagy
#20
Eun Kyung Kim, Jeong-Eun Kwon, Seon-Young Lee, Eun-Jung Lee, Da Som Kim, Su-Jin Moon, Jennifer Lee, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho
Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is a major characteristic of RA. The aims of this study were to investigate the effects of interleukin-17 (IL-17) and IL-17-producing T helper (Th17) cells on resistance to apoptosis in FLSs from RA patients (RA FLSs) and their roles in mitochondrial dysfunction and autophagy. Mitochondrial function was assessed in RA FLSs and FLSs from osteoarthritis patients (OA FLSs)...
January 19, 2017: Cell Death & Disease
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