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https://www.readbyqxmd.com/read/28331879/solid-cystic-pancreatic-tail-desmoid-tumor-with-beta-catenin-positivity
#1
Harsh D Patel, Neil R Desai, Aniruddh Som, Shinil K Shah, Nirav C Thosani
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28329837/associations-across-caregiver-and-care-recipient-symptoms-self-organizing-map-and-meta-analysis
#2
Ari Voutilainen, Nora Ruokostenpohja, Tarja Välimäki
Purpose of the Study: The main objective of this study was to reveal generalizable associations across caregiver burden (CGB), caregiver depression (CGD), care recipient cognitive ability (CRCA), and care recipient behavioral and psychological symptoms of dementia (BPSD). Design and Methods: Studies published between 2004 and 2014 and reporting CGB and/or CGD together with CRCA and/or BPSD were included. Only 95 out of 1,955 studies provided enough data for data clustering with the Self-Organizing Map (SOM) and 27 of them for meta-analyses based on correlation coefficients...
March 10, 2017: Gerontologist
https://www.readbyqxmd.com/read/28324279/soil-organic-matter-as-sole-indicator-of-soil-degradation
#3
S E Obalum, G U Chibuike, S Peth, Y Ouyang
Soil organic matter (SOM) is known to play vital roles in the maintenance and improvement of many soil properties and processes. These roles, which largely influence soil functions, are a pool of specific contributions of different components of SOM. The soil functions, in turn, normally define the level of soil degradation, viewed as quantifiable temporal changes in a soil that impairs its quality. This paper aims at providing a generalized assessment of the current state of knowledge on the usefulness of SOM in monitoring soil degradation, based on its influence on the physical, chemical and biological properties and processes of soils...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28322513/site-of-metabolism-prediction-based-on-ab-initio-derived-atom-representations
#4
Arndt R Finkelmann, Andreas H Göller, Gisbert Schneider
Machine learning models for site of metabolism (SoM) prediction offer the ability to identify metabolic soft spots in low molecular weight drug molecules at low computational cost and enable data-based reactivity prediction. SoM prediction is an atom classification problem. Successful construction of machine learning models requires atom representations that capture the reactivity-determining features of a potential reaction site. We have developed a descriptor scheme that characterizes an atom's steric and electronic environment and its relative location in the molecular structure...
March 21, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28322046/structure-oxidative-metabolism-relationships-of-substituted-flavones-by-aspergillus-niger
#5
Da-Som Lim, Do-Hyung Lim, Ji-Ho Lee, Eun-Tae Oh, Young Soo Keum
Aspergillus niger is rich source of oxidative enzymes, which are important for many industrial applications. However, systematic evaluation of their metabolic characteristics is limited. In this study, structure-dependent metabolism of flavones by Aspergillus niger were investigated with synthetic substrates. Metabolic inhibitor studies suggested that cytochrome P450s are the major enzymes in oxidative metabolism. The reactions include ring hydroxylation, O-demethylation, sulfone/sulfoxide formation, and oxidation of alkyls to carboxy groups...
March 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28317635/a-depressed-heart-atrial-fibrillation-and-pulmonary-hypertension-in-severe-pectus-excavatum
#6
Sumit Som, Tatyana Danilov
No abstract text is available yet for this article.
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28314220/characterization-of-soil-organic-matter-by-ft-ir-spectroscopy-and-its-relationship-with-chlorpyrifos-sorption
#7
María Eugenia Parolo, Mónica Claudia Savini, Ruth Miriam Loewy
Sorption of non-ionic organic compounds to soil is usually expressed as the carbon-normalized partition coefficient (KOC) assuming that the main factor that influences the amount sorbed is the organic carbon content (OC) of the soil. However, KOC can vary across a range of soils. The influence of certain soil characteristics on the chlorpyrifos KOC values variation for 12 representative soils of the Northpatagonian Argentinian region with different physicochemical properties was investigated for this study...
March 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28299568/time-lapse-effect-of-ancient-plant-coal-biochar-on-some-soil-agrochemical-parameters-and-soil-characteristics
#8
Tamás Kocsis, Borbála Biró, Ákos Ulmer, Mónika Szántó, Zsolt Kotroczó
Biochar is a solid material obtained from reductive, oxygen-free processes, i.e. the thermo-chemical conversion of biomass in oxygen-limited environment. The obtained products have high carbon sequestration potential and strong nutrient-water absorption capacities because of the enlarged carbon surfaces. It is not yet clear how carbon stimulates agrochemical parameters in soil and how those characteristics are developing as time goes on a long-term basis. Samples of ancient (25, 35, 80 years old) plant coal-affected soils were collected in a temperate deciduous forest site located in the south part of the Bükk Mountains (in North Eastern Hungary)...
March 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28296010/overview-of-iron-metabolism-in-health-and-disease
#9
Som Dev, Jodie L Babitt
Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients...
March 15, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28283282/custirsen-in-combination-with-docetaxel-and-prednisone-for-patients-with-metastatic-castration-resistant-prostate-cancer-synergy-trial-a-phase-3-multicentre-open-label-randomised-trial
#10
Kim N Chi, Celestia S Higano, Brent Blumenstein, Jean-Marc Ferrero, James Reeves, Susan Feyerabend, Gwenaelle Gravis, Axel S Merseburger, Arnulf Stenzl, Andries M Bergman, Som D Mukherjee, Pawel Zalewski, Fred Saad, Cindy Jacobs, Martin Gleave, Johann S de Bono
BACKGROUND: Clusterin is a chaperone protein associated with treatment resistance and upregulated by apoptotic stressors such as chemotherapy. Custirsen is a second-generation antisense oligonucleotide that inhibits clusterin production. The aim of the SYNERGY trial was to investigate the effect of custirsen in combination with docetaxel and prednisone on overall survival in patients with metastatic castration-resistant prostate cancer. METHODS: SYNERGY was a phase 3, multicentre, open-label, randomised trial set at 134 study centres in 12 countries...
March 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28282896/performance-and-challenges-of-service-oriented-architecture-for-wireless-sensor-networks
#11
Remah Alshinina, Khaled Elleithy
Wireless Sensor Networks (WSNs) have become essential components for a variety of environmental, surveillance, military, traffic control, and healthcare applications. These applications face critical challenges such as communication, security, power consumption, data aggregation, heterogeneities of sensor hardware, and Quality of Service (QoS) issues. Service-Oriented Architecture (SOA) is a software architecture that can be integrated with WSN applications to address those challenges. The SOA middleware bridges the gap between the high-level requirements of different applications and the hardware constraints of WSNs...
March 8, 2017: Sensors
https://www.readbyqxmd.com/read/28279534/winter-ecology-of-a-subalpine-grassland-effects-of-snow-removal-on-soil-respiration-microbial-structure-and-function
#12
Konstantin Gavazov, Johannes Ingrisch, Roland Hasibeder, Robert T E Mills, Alexandre Buttler, Gerd Gleixner, Jukka Pumpanen, Michael Bahn
Seasonal snow cover provides essential insulation for mountain ecosystems, but expected changes in precipitation patterns and snow cover duration due to global warming can influence the activity of soil microbial communities. In turn, these changes have the potential to create new dynamics of soil organic matter cycling. To assess the effects of experimental snow removal and advanced spring conditions on soil carbon (C) and nitrogen (N) dynamics, and on the biomass and structure of soil microbial communities, we performed an in situ study in a subalpine grassland in the Austrian Alps, in conjunction with soil incubations under controlled conditions...
March 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28269437/artsens%C3%A2-mobile-a-portable-image-free-platform-for-automated-evaluation-of-vascular-stiffness
#13
Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam
Vascular stiffness is a key physiological marker significant in screening and early diagnosis of vascular disease. However, state of art techniques for vascular stiffness evaluation are not suited for field deployment. We present ARTSENS® Mobile, a portable, image-free ultrasound technology platform for automated evaluation of carotid artery stiffness, amenable for field deployment. The technology utilises a single element ultrasound transducer operated in pulse echo modality to investigate arterial wall dynamics, assisted by intelligent algorithms for wall identification and motion tracking to completely automate the measurement...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268966/attractor-shape-descriptors-for-balance-impairment-assessment-in-parkinson-s-disease
#14
Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga
In this paper, we propose a computational framework using high-dimensional shape descriptors of reconstructed attractors of center-of-pressure (CoP) tracings collected from subjects with Parkinson's disease while performing dynamical posture shifts, to quantitatively assess balance impairment. Using a dataset collected from 60 subjects, we demonstrated that the proposed method outperforms traditional methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263602/aldehyde-oxidase-mediated-metabolism-in-drug-like-molecules-a-combined-computational-and-experimental-study
#15
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng, Xiaoyan Chen
Aldehyde oxidase (AOX) is an important drug-metabolizing enzyme. However, the current in vitro models for evaluating AOX metabolism are sometimes misleading, and preclinical animal models generally fail to predict human AOX-mediated metabolism. In this study, we report a combined computational and experimental investigation of drug-like molecules that are potential aldehyde oxidase substrates, of which multiple sites of metabolism (SOMs) mediated by AOX and their preferences for the reaction can be unambiguously identified...
March 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28258733/-perioperative-gabapentin-and-pregabalin-in-cardiac-surgery-a-systematic-review-and-meta-analysis
#16
Souvik Maitra, Dalim K Baidya, Sulagna Bhattacharjee, Anirban Som
OBJECTIVES: Sternotomy for cardiac surgeries causes significant postoperative pain and when not properly managed may cause significant morbidity. As neuropathic pain is a significant component here, gabapentin and pregabalin may be effective in these patients and may reduce postoperative opioid consumption. The purpose of this systematic review was to find out efficacy of gabapentin and pregabalin in acute postoperative pain after cardiac surgery. METHODS: Published prospective human randomized clinical trials, which compared preoperative and/or postoperative gabapentin/pregabalin with placebo or no treatment for postoperative pain management after cardiac surgery has been included in this review...
March 1, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28252302/influence-of-organic-chemicals-on-water-molecule-bridges-in-soil-organic-matter-of-a-sapric-histosol
#17
Pavel Ondruch, Jiri Kucerik, Zacharias Steinmetz, Gabriele E Schaumann
Water molecules in soil organic matter (SOM) can form clusters bridging neighboring molecular segments (water molecule bridges, WaMBs). WaMBs are hypothesized to enhance the physical entrapment of organic chemicals and to control the rigidity of the SOM supramolecular structure. However, the understanding of WaMBs dynamics in SOM is still limited. We investigated the relation between WaMBs stability and the physicochemical properties of their environment by treating a sapric histosol with various solvents and organic chemicals...
March 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28236479/glyphosate-binding-in-soil-as-revealed-by-sorption-experiments-and-quantum-chemical-modeling
#18
Peter Gros, Ashour Ahmed, Oliver Kühn, Peter Leinweber
The herbicide glyphosate (GLP) is supposed to be rapidly degraded or adsorbed strongly by soil solids but findings in soil years after application and concentrations in waters above legal limits question a harmless disappearance. Therefore, we conducted batch sorption experiments with 23 thoroughly characterized arable surface soils, correlated isotherm coefficients with numerous inorganic and organic soil parameters, and investigated GLP-SOM-complexes by quantum-chemical modeling. The Freundlich sorption model yielded the best fits, and coefficients Kf and nf were correlated positively with the contents of clay/silt...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28236205/influence-of-oral-probiotic-streptococcus-salivarius-k12-on-ear-and-oral-cavity-health-in-humans-systematic-review
#19
Katarina Zupancic, Valentina Kriksic, Irena Kovacevic, Dujo Kovacevic
Traditionally, probiotics are linked to the good health of the intestine and most clinical studies focus on that field. Evidence of oral probiotic use for ear and oral cavity disease prevention with impact on human health is limited. This work reviews existing studies and literature on Streptococcus salivarius K12 as an oral probiotic and effects of S. salivarius K12 on human ear and oral cavity human health. The studies were accessed via database searches: MEDLINE, PubMed, and Elsevier. The search included/focused on/encompassed publications from 2003 to 2016 with keywords related to K12 Streptococcus salivarius, bacteriocin-like inhibitory substances (BLIS) K12, probiotic K12 salivarius, and K12 probiotic health effects...
February 24, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28235657/effects-of-chronic-waterborne-cadmium-and-zinc-interactions-on-tissue-specific-metal-accumulation-and-reproduction-in-fathead-minnow-pimephales-promelas
#20
Melissa K Driessnack, Ankur Jamwal, Som Niyogi
The present study was designed to evaluate the interactive effects of chronic waterborne cadmium (Cd) and zinc (Zn) on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Trios (1 male: 2 female; n=6-7) of fish were exposed for 21 days to: (i) control (no added Cd or Zn), (ii) waterborne Cd (7µg/L), (iii) waterborne Zn (170µg/L), and (iv) Cd and Zn in mixture (7 and 170µg/L, respectively). Exposure to Cd or Zn alone did not elicit any significant effect on reproductive output (cumulative egg production) relative to the control, however exposure to Cd and Zn in mixture resulted in a ~50% decrease in fish fecundity...
February 21, 2017: Ecotoxicology and Environmental Safety
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