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https://www.readbyqxmd.com/read/28735013/simultaneous-intrinsic-signal-imaging-of-auditory-and-visual-cortex-reveals-profound-effects-of-acute-hearing-loss-on-visual-processing
#1
Manuel Teichert, Jürgen Bolz
It has been suggested that primary sensory cortices do not work in isolation but receive subthreshold inputs originating from other senses. However, repercussions of an acute loss of one sense on multimodal sensory processing remain elusive. Here we investigated the early effects of acute hearing loss on visual processing in adult mice. For this, we developed a method to simultaneously map the primary auditory (A1) and visual cortex (V1) using periodic intrinsic optical imaging. We found that reducing sound evoked A1 responsiveness due to the induction of conductive hearing loss (CHL) led to a concomitant increase of visually driven V1 activity...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28726382/interparticle-reactions-an-emerging-direction-in-nanomaterials-chemistry
#2
K R Krishnadas, Ananya Baksi, Atanu Ghosh, Ganapati Natarajan, Anirban Som, Thalappil Pradeep
Nanoparticles exhibit a rich variety in terms of structure, composition, and properties. However, reactions between them remain largely unexplored. In this Account, we discuss an emerging aspect of nanomaterials chemistry, namely, interparticle reactions in solution phase, similar to reactions between molecules, involving atomically precise noble metal clusters. A brief historical account of the developments, starting from the bare, gas phase clusters, which led to the synthesis of atomically precise monolayer protected clusters in solution, is presented first...
July 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#3
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28711270/evaluation-of-the-yield-molar-mass-of-exopolysaccharides-and-rheological-properties-of-gels-formed-during-fermentation-of-milk-by-streptococcus-thermophilus-strains-st-143-and-st-10255y
#4
Som N Khanal, John A Lucey
The yield and chemical structures of exopolysaccharides (EPS) produced by many strains of Streptococcus thermophilus have been characterized. However, the kinetics (or production profile) for EPS during milk fermentation is not clear. In this study, we investigated whether any differences existed in the yield and molar mass of EPS when milk was fermented at the same acidification rate by 2 strains of S. thermophilus (St-143 and ST-10255y). The type of EPS produced by these 2 strains is different. Milk samples were analyzed for EPS concentration every 30 min during a fermentation period of 270 min (final pH 4...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28702006/the-conserved-actinobacterial-two-component-system-mtrab-coordinates-chloramphenicol-production-with-sporulation-in-streptomyces-venezuelae-nrrl-b-65442
#5
Nicolle F Som, Daniel Heine, Neil A Holmes, John T Munnoch, Govind Chandra, Ryan F Seipke, Paul A Hoskisson, Barrie Wilkinson, Matthew I Hutchings
Streptomyces bacteria make numerous secondary metabolites, including half of all known antibiotics. Production of antibiotics is usually coordinated with the onset of sporulation but the cross regulation of these processes is not fully understood. This is important because most Streptomyces antibiotics are produced at low levels or not at all under laboratory conditions and this makes large scale production of these compounds very challenging. Here, we characterize the highly conserved actinobacterial two-component system MtrAB in the model organism Streptomyces venezuelae and provide evidence that it coordinates production of the antibiotic chloramphenicol with sporulation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28695895/corrigendum-synthesis-of-sr2si5n8-ce-3-phosphors-for-white-leds-via-efficient-chemical-vapor-deposition
#6
Che-Yuan Yang, Sudipta Som, Subrata Das, Chung-Hsin Lu
This corrects the article DOI: 10.1038/srep45832.
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695806/illness-attribution-of-outpatients-with-multiple-somatic-symptoms-in-peking-union-medical-college-hospital
#7
Tao Li, Xia Hong, Nana Xiong, Jing Jiang, Xiayuan Sun, Liming Zhu, Guoqing Tian, Jing Wei
Objective To explore the characteristics of illness attribution of outpatients with multiple somatic symptoms in Peking Union Medical College Hospital. Methods It was a cross-sectional study conducted from March to October,2012. A total of 150 outpatients were recruited from the departments of Gastroenterology,Traditional Chinese Medicine and Psychological Medicine by convenience sampling. Somatic symptom scale of the Patient Health Questionnaire (PHQ-15) was used to screening each patient in the waiting list...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28695494/identifying-trace-metal-distribution-and-occurrence-in-sediments-inundated-soils-and-non-flooded-soils-of-a-reservoir-catchment-using-self-organizing-maps-an-artificial-neural-network-method
#8
Fangyan Cheng, Shiliang Liu, Yijie Yin, Yueqiu Zhang, Qinghe Zhao, Shikui Dong
The Lancang-Mekong River is a trans-boundary river which provides a livelihood for over 60 million people in Southeast Asia. Its environmental security is vital to both local and regional inhabitants. Efforts have been undertaken to identify controlling factors of the distribution of trace metals in sediments and soils of the Manwan Reservoir catchment in the Lancang-Mekong River basin. The physicochemical attributes of 63 spatially distributed soil and sediment samples, along with land-use, flooding, topographic, and location characteristics, were analyzed using the Self-Organizing Map (SOM) methodology...
July 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28689982/network-level-control-of-frequency-tuning-in-auditory-cortex
#9
Hiroyuki K Kato, Samuel K Asinof, Jeffry S Isaacson
Lateral inhibition is a fundamental circuit operation that sharpens the tuning properties of cortical neurons. This operation is classically attributed to an increase in GABAergic synaptic input triggered by non-preferred stimuli. Here we use in vivo whole-cell recording and two-photon Ca(2+) imaging in awake mice to show that lateral inhibition shapes frequency tuning in primary auditory cortex via an unconventional mechanism: non-preferred tones suppress both excitatory and inhibitory synaptic inputs onto layer 2/3 cells ("network suppression")...
July 19, 2017: Neuron
https://www.readbyqxmd.com/read/28689040/unsupervised-learning-techniques-reveal-heterogeneity-in-memory-cd8-t-cell-differentiation-following-acute-chronic-and-latent-viral-infections
#10
Mingyong Liu, Erik S Barton, Ryan N Jennings, Darby G Oldenburg, Juliann M Whirry, Douglas W White, Jason M Grayson
CD8(+) T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8(+) T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8(+) T cells into uninfected recipients, and examined surface proteins, cytokines and transcription factors following infection with the Armstrong (acute) or Clone 13 (chronic) strains of lymphocytic choriomeningitis virus (LCMV), or murine gammaherpesvirus 68 (MHV68) expressing the LCMV epitope D(b)GP33-41...
September 2017: Virology
https://www.readbyqxmd.com/read/28686209/detailed-characterization-of-sympathetic-chain-ganglia-schg-neurons-supplying-the-skin-of-the-porcine-hindlimb
#11
Anna Kozłowska, Anita Mikołajczyk, Mariusz Majewski
It is generally known that in the skin sympathetic fibers innervate various dermal structures, including sweat glands, blood vessels, arrectores pilorum muscles and hair follicles. However, there is a lack of data about the distribution and chemical phenotyping of the sympathetic chain ganglia (SChG) neurons projecting to the skin of the pig, a model that is physiologically and anatomically very representative for humans. Thus, the present study was designed to establish the origin of the sympathetic fibers supplying the porcine skin of the hind leg, and the pattern(s) of putative co-incidence of dopamine-β-hydroxylase (DβH) with pituitary adenylate cyclase-activating polypeptide (PACAP), somatostatin (SOM), neuronal nitric oxide synthase, substance P, vasoactive intestinal peptide, neuropeptide Y (NPY), leu5-enkephalin and galanin (GAL) using combined retrograde tracing and double-labeling immunohistochemistry...
July 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28683364/sex-specific-clustering-of-metabolic-risk-factors-and-their-association-with-incident-cardiovascular-diseases-a-population-based-prospective-study
#12
Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh, Fatemeh Eskandari
BACKGROUND AND AIMS: We identified distinct patterns of metabolic risk factors (MRF), and examined their association with subsequent cardiovascular disease (CVD) risk. METHODS: The study sample included 8113 participants (45% men) aged ≥30 years. Self-organizing map (SOM) was applied to clustering of five dichotomized MRF in men and women. MRF were included: low estimated glomerular filtration rate (eGFR), high fasting plasma glucose (FPG), high total cholesterol (TC), high systolic blood pressure (SBP) and high body mass index (BMI)...
June 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28683331/spatiotemporal-and-species-variations-in-prokaryotic-communities-associated-with-sediments-from-surface-flow-constructed-wetlands-for-treating-swine-wastewater
#13
Fen Jia, Cui Lai, Liang Chen, Guangming Zeng, Danlian Huang, Feng Liu, Xi Li, Pei Luo, Jinshui Wu, Lei Qin, Chen Zhang, Min Cheng, Piao Xu
Microorganisms are the main mechanisms of pollutants removals in constructed wetlands (CWs) used for wastewater treatment. However, the different biological processes and variations of prokaryotic community in CWs remain poorly understood. In this study, we applied a high-throughput sequencing technique to investigate the prokaryotic communities associated with sediments from pilot-scale surface-flow constructed wetlands (SFCWs) treating swine wastewater (SW) of varying strengths. Our results revealed that highly diverse prokaryotic communities were present in the SFCWs, with Proteobacteria (16...
June 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28683305/somatostatin-neurons-in-the-basal-forebrain-promote-high-calorie-food-intake
#14
Chen Zhu, Yun Yao, Yan Xiong, Mingxiu Cheng, Jing Chen, Rui Zhao, Fangzhou Liao, Runsheng Shi, Sen Song
Obesity has become a global issue, and the overconsumption of food is thought to be a major contributor. However, the regulatory neural circuits that regulate palatable food consumption remain unclear. Here, we report that somatostatin (SOM) neurons and GABAergic (VGAT) neurons in the basal forebrain (BF) play specific roles in regulating feeding. Optogenetic stimulation of BF SOM neurons increased fat and sucrose intake within minutes and promoted anxiety-like behaviors. Furthermore, optogenetic stimulation of projections from BF SOM neurons to the lateral hypothalamic area (LHA) selectively resulted in fat intake...
July 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28681867/highly-anisotropic-thermal-conductivity-of-discotic-nematic-liquid-crystalline-films-with-homeotropic-alignment
#15
Dong-Gyun Kim, Yun Ho Kim, Tae Joo Shin, Eun Jung Cha, Da Som Kim, Byoung Gak Kim, Youngjae Yoo, Yong Seok Kim, Mi Hye Yi, Jong Chan Won
Discotic nematic liquid crystal (DNLC) films are prepared by thermal treatment and a photo-crosslinking reaction inside sandwiched glass plates. The DNLC films exhibit outstanding in-plane thermal conductivity which is much larger than cross-plane thermal conductivity. The homeotropic alignment and higher crosslinking density of DNLCs in the films further increase the thermal conductivity anisotropy.
July 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28674926/enhancement-of-gamma-aminobutyric-acid-gaba-levels-using-an-autochthonous-lactobacillus-futsaii-cs3-as-starter-culture-in-thai-fermented-shrimp-kung-som
#16
Chatthaphisuth Sanchart, Onnicha Rattanaporn, Dietmar Haltrich, Pimpimol Phukpattaranont, Suppasil Maneerat
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid, which has a variety of well-characterized beneficial physiological functions. In order to improve GABA levels and the fermentation process of Thai fermented shrimp (Kung-Som), autochthonous Lactobacillus futsaii CS3 was inoculated as a starter culture into Kung-Som, and its effects on the quality of Kung-Som were studied. The optimal conditions for GABA production in Kung-Som as obtained by response surface methodology (RSM) using a central composite design (CCD) were an inoculum size of roughly 10(7) CFU/g (X1) of L...
August 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28674519/somatostatin-ires-cre-mice-between-knockout-and-wild-type
#17
Cécile Viollet, Axelle Simon, Virginie Tolle, Alexandra Labarthe, Dominique Grouselle, Yann Loe-Mie, Michel Simonneau, Guillaume Martel, Jacques Epelbaum
The neuropeptide somatostatin (SOM) is widely expressed in rodent brain and somatostatin-IRES-Cre (SOM-cre) mouse strains are increasingly used to unravel the physiology of SOM-containing neurons. However, while knock-in targeting strategy greatly improves Cre-Lox system accuracy, recent reports have shown that genomic insertion of Cre construct per se can markedly affect physiological function. We show that Cre transgene insertion into the 3'UTR of the somatostatin gene leads to the selective and massive depletion of endogenous SOM in all tested brain regions...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28670989/-sudden-cardiac-death-due-to-sarcoidosis-case-report
#18
István Sejben, Zoltán Som, Gábor Cserni
Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. The authors present the case of a 44-year-old man with bradycardia. On admission, second degree Mobitz II, then third degree atrioventricular block was diagnosed...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28669476/adsorption-of-17-%C3%AE-ethyl-estradiol-with-the-competition-of-bisphenol-a-on-the-marine-sediment-of-hong-kong
#19
Ying-Heng Fei, Kenneth M Y Leung, Xiao-Yan Li
The present experimental study was to characterize the adsorption behavior of 17 α-ethyl estradiol (EE2) onto marine sediment in both the single and binary solute systems. Stepwise spiking was innovatively performed to better understand the competition effects. Adsorption of EE2 on the marine sediment can be well fitted by the Freundlich model with an affinity coefficient (KF) varying from 15.8 to 39.8L/kg. It was significantly influenced by SOM and the particle properties. Co-presence of BPA brought about a significant competition effect on the adsorption of EE2, leading to a reduced EE2 adsorption...
June 29, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28666221/tailoring-the-electrochemical-properties-of-ed-ion-exchange-membranes-based-on-the-synergism-of-tio2-nanoparticles-co-go-nanoplates
#20
S M Hosseini, E Jashni, S Amani, B Van der Bruggen
In this paper, the synergetic influence of various weight ratios of TiO2 nanoparticles (NPs)/graphene oxide nanoplates (GONs) in the matrix of ion exchange membranes was examined in order to adapt their electrokinetic properties based on the combination of the high specific surface area of GONs and the antifouling ability of TiO2 nanoparticles. The morphology, physico-chemical features and ionic transport behavior of prepared membranes was studied. Scanning optical microscopy (SOM) and scanning electron microscopy (SEM) images showed a uniform surface for the lab-made membranes relatively...
June 15, 2017: Journal of Colloid and Interface Science
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