keyword
MENU ▼
Read by QxMD icon Read
search

Target controlled infusion

keyword
https://www.readbyqxmd.com/read/29648781/polymer-magnetic-composite-fibers-for-remote-controlled-drug-release
#1
Ayomi Sheamilka Perera, Siqi Zhang, Shervanthi Homer-Vanniasinkam, Marc-Olivier Coppens, Mohan Edirisinghe
An efficient method is reported, for fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol (PVA), incorporated with citric acid coated Fe3O4 magnetic nanoparticles (MNPs), are subject to infusion gyration, to generate 100-300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29643541/-preparation-quality-control-and-thyroid-molecule-imaging-of-solid-target-based-radionuclide-ioine-124
#2
H Zhu, F Wang, X Y Guo, L Q Li, D B Duan, Z B Liu, Z Yang
OBJECTIVE: To provide useful information for the further production and application of this novel radio-nuclide for potential clinical application. METHODS: 124 Te (p,n) 124 I nuclide reaction was used for the 124 I production. Firstly, the target material, 124 TeO2 (200 mg) and Al2O3 (30 mg) mixture, were compressed into the round platinum based solid target by tablet device. HM-20 medical cyclotron was applied to irradiate the solid target slice for 6-10 h with helium and water cooling...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29629873/a-maternally-sequestered-biopolymer-stabilized-vascular-endothelial-growth-factor-vegf-chimera-for-treatment-of-preeclampsia
#3
Omar C Logue, Fakhri Mahdi, Heather Chapman, Eric M George, Gene L Bidwell
BACKGROUND: Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology. One of these factors, soluble fms-like tyrosine kinase-1, is believed to sequester vascular endothelial growth factor (VEGF), leading to systemic endothelial dysfunction and hypertension. With the goal of targeting soluble fms-like tyrosine kinase-1 while simultaneously preventing fetal exposure to VEGF, we fused VEGF to elastin-like polypeptide, a biopolymer carrier that does not cross the placental barrier (ELP-VEGF)...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29625592/orphan-receptor-gpr37l1-contributes-to-the-sexual-dimorphism-of-central-cardiovascular-control
#4
James L J Coleman, Margaret A Mouat, Jianxin Wu, Nikola Jancovski, Jaspreet K Bassi, Andrea Y Chan, David T Humphreys, Nadine Mrad, Ze-Yan Yu, Tony Ngo, Siiri Iismaa, Cristobal G Dos Remedios, Michael P Feneley, Andrew M Allen, Robert M Graham, Nicola J Smith
BACKGROUND: Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and detectable as mRNA in the heart and kidney. GPR37L1 ablation was reported to cause hypertension and left ventricular hypertrophy, and thus, we sought to further define the role of GPR37L1 in blood pressure homeostasis. METHODS: We investigated the cardiovascular effects of GPR37L1 using wild-type (GPR37L1wt/wt ) and null (GPR37L1KO/KO ) mice established on a C57BL/6J background, both under baseline conditions and during AngII infusion...
April 6, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29624535/comparison-of-intraoperative-sedation-with-dexmedetomidine-versus-propofol-on-acute-postoperative-pain-in-total-knee-arthroplasty-under-spinal-anesthesia-a-randomized-trial
#5
Hyun-Jung Shin, Sang-Hwan Do, Jae-Sung Lee, Tae-Kyun Kim, Hyo-Seok Na
BACKGROUND: In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with propofol. METHODS: Forty-eight patients were enrolled and randomly assigned to either a dexmedetomidine group (n = 24), which received a loading dose of 1 μg/kg dexmedetomidine over 10 minutes, followed by a continuous infusion of 0...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29623216/feasibility-of-mesenchymal-stem-cell-culture-expansion-for-a-phase-i-clinical-trial-in-multiple-sclerosis
#6
Sarah M Planchon, Karen T Lingas, Jane Reese Koç, Brittney M Hooper, Basabi Maitra, Robert M Fox, Peter B Imrey, Kylie M Drake, Micheala A Aldred, Hillard M Lazarus, Jeffrey A Cohen
Background: Multiple sclerosis is an inflammatory, neurodegenerative disease of the central nervous system for which therapeutic mesenchymal stem cell transplantation is under study. Published experience of culture-expanding multiple sclerosis patients' mesenchymal stem cells for clinical trials is limited. Objective: To determine the feasibility of culture-expanding multiple sclerosis patients' mesenchymal stem cells for clinical use. Methods: In a phase I trial, autologous, bone marrow-derived mesenchymal stem cells were isolated from 25 trial participants with multiple sclerosis and eight matched controls, and culture-expanded to a target single dose of 1-2 × 106 cells/kg...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29621963/detecting-autologous-blood-transfusion-in-doping-control-biomarkers-of-blood-aging-and-storage-measured-by-flow-cytofluorimetry
#7
Francesco Botre, Roberta Acciarini, Ilenia De Benedittis, Xavier de la Torre, Daniela Pirri, Mariangela Prete, Alessandra Stampella, Enza Vernucci
Backgorund: Blood transfusions are banned by the World Anti-Doping Agency as a form of "blood doping". A method of detection of homologous blood transfusion (HBT) has been implemented by the accredited anti-doping laboratories worldwide; however, no internationally recognized method has been finalized so far for the direct detection of autologous blood transfusions, which can at present be revealed only by targeted longitudinal profiling of key blood parameters. METHODS: The present article reports the results of an investigation aimed to pre-select potential biomarkers of blood aging and storage that can be measured to identify the presence in the sample of re-infused blood...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29619926/parenteral-nutrition-and-insulin-per-protocol-improve-diabetes-management-after-total-pancreatectomy
#8
Sakshi Andersen, Andreas Andersen, Lene Ringholm, Carsten Palnæs Hansen, Jan Storkholm, Kerstin Lillpers, Charlotte Schiøtz, Elisabeth Reinhardt Mathiesen
INTRODUCTION: Pancreatogenic diabetes develops in patients undergoing total pancreatectomy and complicates post-surgical management. The aim of this study was to compare parenteral nutrition (PN) with protocolled insulin treatment to intravenous glucose treatment after total pancreatectomy. METHODS: This was a retrospective study of 97 patients undergoing total pancreatectomy between 2009 and 2014. Patients were divided into a PN cohort (n = 57) and a glucose cohort (n = 40)...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29605320/symposium-review-amino-acid-uptake-by-the-mammary-glands-where-does-the-control-lie
#9
John P Cant, Julie J M Kim, Scott R L Cieslar, John Doelman
Milk protein yield responses to changes in the profile of essential amino acids absorbed by the gastrointestinal tract or circulating in blood plasma do not follow the classic limiting amino acid response, in part because of an ability of the mammary glands to modify their blood flow rate and net clearance of amino acids out of plasma. The hypothesis that mammary blood flow is locally regulated to maintain ATP balance accounts for observed changes in flow due to postruminal glucose, insulin, and essential amino acid (EAA) infusions...
March 28, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29599632/comparison-of-the-effects-of-dexmedetomidine-on-the-induction-of-anaesthesia-using-marsh-and-schnider-pharmacokinetic-models-of-propofol-target-controlled-infusion
#10
Wan Mohd Nazaruddin Wan Hassan, Hai Siang Tan, Rhendra Hardy Mohamed Zaini
Background: The study aimed to determine the effects of dexmedetomidine on the induction of anaesthesia using different models (Marsh and Schnider) of propofol target-controlled infusion (TCI). Methods: Sixty-four patients aged 18-60 years, American Society of Anaesthesiologists (ASA) class I-II who underwent elective surgery were randomised to a Marsh group ( n = 32) or Schnider group ( n = 32). All the patients received a 1 μg/kg loading dose of dexmedetomidine, followed by TCI anaesthesia with remifentanil at 2 ng/mL...
February 2018: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29589170/computerized-tests-to-evaluate-recovery-of-cognitive-function-after-deep-sedation-with-propofol-and-remifentanil-for-colonoscopy
#11
Xavier Borrat, Marta Ubre, Raquel Risco, Pedro L Gambús, Angela Pedroso, Aina Iglesias, Gloria Fernandez-Esparrach, Àngels Ginés, Jaume Balust, Graciela Martínez-Palli
The use of sedation for diagnostic procedures including gastrointestinal endoscopy is rapidly growing. Recovery of cognitive function after sedation is important because it would be important for most patients to resume safe, normal life soon after the procedure. Computerized tests have shown being accurate descriptors of cognitive function. The purpose of the present study was to evaluate the time course of cognitive function recovery after sedation with propofol and remifentanil. A prospective observational double blind clinical study conducted in 34 young healthy adults undergoing elective outpatient colonoscopy under sedation with the combination of propofol and remifentanil using a target controlled infusion system...
March 27, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29582176/hypoglycemia-prevention-by-algorithm-design-during-intravenous-insulin-infusion
#12
REVIEW
Susan Shapiro Braithwaite, Lisa P Clark, Thaer Idrees, Faisal Qureshi, Oluwakemi T Soetan
PURPOSE OF REVIEW: This review examines algorithm design features that may reduce risk for hypoglycemia while preserving glycemic control during intravenous insulin infusion. We focus principally upon algorithms in which the assignment of the insulin infusion rate (IR) depends upon maintenance rate of insulin infusion (MR) or a multiplier. RECENT FINDINGS: Design features that may mitigate risk for hypoglycemia include use of a mid-protocol bolus feature and establishment of a low BG threshold for temporary interruption of infusion...
March 26, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29580843/in-clinic-secondary-tracheoesophageal-puncture-and-voice-prosthesis-placement-in-laryngectomees
#13
E Ricci, G Riva, F Dagna, E Seglie, A L Cavalot
Secondary tracheoesophageal puncture (TEP) with voice prosthesis placement represents one of the possibility to restore vocal function after total laryngectomy. However, some patients have comorbidities that contraindicate general anesthesia. In our department, an in-clinic TEP procedure for retrograde voice prosthesis placement was developed. It allows the immediate placement of the prosthesis and the avoidance of the use of dilators. We described our technique with advantages and pitfalls. The Provox Vega Puncture Set was used...
March 23, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29579636/determination-of-dexmedetomidine-by-uhplc-ms-ms-and-its-application-to-evaluate-the-effect-of-dexmedetomidine-concentration-on-the-target-controlled-infusion-concentration-of-propofol
#14
Zhuoling Zheng, Shuyu Zhang, Wudi Ma, Lingyi Zhang, Ling Huang, Wenqi Huang, Min Huang, Zhongxing Wang, Jiali Li
The combination of dexmedetomidine (DEX) and propofol (PPF) is extensively used in the field of anaesthesiology. This study aimed to develop and validate a rapid, simple and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of DEX in human plasma. The method was applied to evaluate the effect of DEX concentration on the target-controlled infusion (TCI) concentration of PPF. Analytes were separated on a Waters XTERRA® MS C18 column with a mobile phase of acetonitrile-methanol-water containing 0...
March 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29576705/antibacterial-activity-of-azadirachta-indica-pongamia-pinnata-psidium-guajava-and-mangifera-indica-and-their-mechanism-of-action-against-streptococcus-mutans
#15
Dikonketso Cathrine Bodiba, Preety Prasad, Ajay Srivastava, Brigdet Crampton, Namrita Sharan Lall
Background: Curative plants have reportedly been used to make chewing sticks/toothbrushes intended for the treatment of oral diseases. Objective: The in vitro antibacterial activities of Azadirachta indica , Pongamia pinnata , Psidium guajava , and Mangifera indica were evaluated against Streptococcus mutans , along with the cytotoxicity and antioxidant and synergistic potentials. The effect of M. indica on the expression of crucial virulence genes spaP and gtfB of S...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29575232/the-impact-of-narcotrend%C3%A2-eeg-guided-propofol-administration-on-the-speed-of-recovery-from-pediatric-procedural-sedation-a-randomized-controlled-trial
#16
Frank Weber, Laurence C Walhout, Johanna C Escher
BACKGROUND: Propofol is often used for procedural sedation in children undergoing gastrointestinal endoscopy. Reliable assessment of the depth of hypnosis during the endoscopic procedure is challenging. Processed electroencephalography using the Narcotrend Index can help titrating propofol to a predefined sedation level. AIMS: The aim of this trial was to investigate the impact of Narcotrend Index-guided titration of propofol delivery on the speed of recovery. METHODS: Children, aged 12-17 years, undergoing gastrointestinal endoscopy under procedural sedation, had propofol delivered via target controlled infusion either based on Narcotrend Index guidance (group NI) or standard clinical parameters (group C)...
March 25, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29574681/effect-of-goal-directed-haemodynamic-therapy-in-free-flap-reconstruction-for-head-and-neck-cancer
#17
H J Kim, E J Kim, H J Lee, J Y Min, T W Kim, E C Choi, W S Kim, B-N Koo
BACKGROUND: In free flap reconstruction for head and neck cancer, achieving a haemodynamic target using excessive fluid infusion is associated with decreased flap survival rates and extended hospital stays. We hypothesized that goal-directed haemodynamic therapy would improve flap survival rates and shorten hospitalization periods. METHODS: Patients scheduled for free flap reconstruction were randomly assigned to a goal-directed haemodynamic therapy group (n = 31) or a conventional haemodynamic therapy control group (n = 31)...
March 25, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29570501/local-anesthetic-injection-speed-and-common-peroneal-nerve-block-duration-a-randomized-controlled-trial-in-healthy-volunteers
#18
Mikkel Herold Madsen, Claus B Christiansen, Christian Rothe, Asger M Andreasen, Lars H Lundstrøm, Kai H W Lange
BACKGROUND AND OBJECTIVES: The speed of local anesthetic (LA) injections in peripheral regional anesthesia ranges from slow continuous infusions (3-12 mL/h) to rapid manual injections (>7500 mL/h). Optimizing injection speed could augment the spread of LA toward the targeted nerves and influence nerve block characteristics. The objective of this study was to investigate whether injection speed of a single dose of LA affects peripheral nerve block duration. METHODS: After approval from the Danish Regional Scientific Ethics Committee, we enrolled 60 healthy adult volunteers...
March 22, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29568976/pharmacokinetics-and-dynamics-of-intramuscular-and-intranasal-naloxone-an-explorative-study-in-healthy-volunteers
#19
Arne Kristian Skulberg, Ida Tylleskar, Turid Nilsen, Sissel Skarra, Øyvind Salvesen, Trond Sand, Thorsteinn Loftsson, Ola Dale
PURPOSE: This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone formulation 8 mg/ml to intramuscular 0.8 mg. METHODS: Two-way crossover in 12 healthy volunteers receiving naloxone while receiving remifentanil by a target-controlled infusion for 102 min. The group were subdivided into three different doses of remifentanil...
March 22, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29526563/dobutamine-stress-echocardiography-unmasks-early-left-ventricular-dysfunction-in-asymptomatic-patients-with-uncomplicated-type-2-diabetes-a-comprehensive-two-dimensional-speckle-tracking-imaging-study
#20
Clothilde Philouze, Philippe Obert, Stéphane Nottin, Asma Benamor, Olivier Barthez, Falah Aboukhoudir
BACKGROUND: Discrepancies are present in the literature on resting myocardial mechanics in patients with uncomplicated type 2 diabetes mellitus (T2DM). Data are noticeably sparse regarding circumferential function and torsional mechanics. Resting deformation imaging may not be sensitive enough to detect subtle dysfunctions. The aim of this study was thus to comprehensively evaluate myocardial mechanics in patients with T2DM at rest and to investigate whether dobutamine stress echocardiography could unmask functional alterations that would remain otherwise subtle at rest...
March 8, 2018: Journal of the American Society of Echocardiography
keyword
keyword
3316
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"