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Sepsis induced acute kidney injury

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https://www.readbyqxmd.com/read/29682165/urinary-mitochondrial-dna-identifies-renal-dysfunction-and-mitochondrial-damage-in-sepsis-induced-acute-kidney-injury
#1
Qiongyuan Hu, Jianan Ren, Huajian Ren, Jie Wu, Xiuwen Wu, Song Liu, Gefei Wang, Guosheng Gu, Kun Guo, Jieshou Li
Background: Recent animal studies have shown that mitochondrial dysfunction initiates and accelerates renal injury in sepsis, but its role in sepsis remains unknown. Mitochondrial stress or dying cells can lead to fragmentation of the mitochondrial genome, which is considered a surrogate marker of mitochondrial dysfunction. Therefore, we evaluated the efficiency of urinary mitochondrial DNA (UmtDNA) as a marker of renal dysfunction during sepsis-induced acute kidney injury (AKI). Methods: We isolated DNA from plasma and urine of patients...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29669307/long-non-coding-rna-neat1-plays-an-important-role-in-sepsis-induced-acute-kidney-injury-by-targeting-mir-204-and-modulating-the-nf-%C3%AE%C2%BAb-pathway
#2
REVIEW
Yi Chen, Jialing Qiu, Bin Chen, Youping Lin, Yulan Chen, Guojin Xie, Junming Qiu, Huasheng Tong, Dongxin Jiang
This study aimed to explore the role of long non-coding RNA NEAT1 in sepsis-induced acute kidney injury (AKI). The expression levels of NEAT1 in sepsis-induced AKI patients were detected. The rat mesangial cells (RMCs) were treated with lipopolysaccharide (LPS) to induce cell injury. Then, the effects of NEAT1 suppression on the cell viability, apoptosis, cytokines expression, and oxidative stress in the LPS-stimulated RMCs were tested. The regulatory miRNA of NEAT1, as well as the target genes of this miRNA, were investigated...
April 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29667230/nephropreventing-effect-of-hypoxia-inducible-factor-1%C3%AE-in-a-rat-model-of-ischemic-reperfusion-acute-kidney-injury
#3
Huiling Wang, Nanmei Liu, Rui Li, Jun Tian, Weifeng Hu, Jinyuan Zhang
Acute kidney injury (AKI) often occurs in 5% hospitalized patients and in 50% sepsis patients with acute renal dysfunction. However, there is no safe and effective therapeutic strategies until now. Hypoxia condition is closely related to renal injuries and function under AKI. As HIF-1α is critical for cellular response to hypoxia, we investigated the protective effect of HIF-1α in a rat AKI model. We found that HIF-1 α injection improved the survival of rat with AKI, and the level of Cr and BUN was also increased...
April 17, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29620262/dynamic-expression-and-roles-of-sequestome%C3%A2-1-p62-in-lps%C3%A2-induced-acute-kidney-injury-in-mice
#4
Ting Li, Jie Zhao, Shuying Miao, Yunfei Xu, Xianzhong Xiao, Ying Liu
Acute kidney injury (AKI) is one of the most common complications of sepsis. The roles of autophagy in AKI have been demonstrated in previous studies. Sequestosome‑1 (p62) has been demonstrated to serve essential roles in autophagy. The dysregulation of autophagy causes p62 accumulation, which is associated with increased inflammation and tumorigenesis. However, the expression patterns and role of p62 in septic AKI remain unknown. The present study detected the renal autophagy level, and the expression and localization of p62, in a lipopolysaccharide (LPS)‑induced AKI mouse model...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29589603/acute-kidney-injury-in-kidney-transplant-patients
#5
C Dudreuilh, R Aguiar, M Ostermann
Managing kidney transplant patients in an acute medical unit can be challenging, as patients have a single functioning kidney, underlying chronic kidney disease, and are immunosuppressed. Transplant patients develop AKI for all usual reasons but the differential diagnosis is wider and includes specific problems, such as obstruction of a single functioning kidney, vascular thrombosis, rejection, drug toxicity and drug-induced thrombotic microangiopathy. Septic AKI is common but again, the differential diagnosis of sepsis is wider...
2018: Acute Medicine
https://www.readbyqxmd.com/read/29573604/value-of-the-combination-of-renal-resistance-index-and-central-venous-pressure-in-the-early-prediction-of-sepsis-induced-acute-kidney-injury
#6
Jieqiong Song, Wei Wu, Yizhou He, Shilong Lin, Duming Zhu, Ming Zhong
PURPOSE: Early prediction of acute kidney injury (AKI) in septic patients is difficult. This study aimed to assess the values of renal resistive index (RI), central venous pressure (CVP), and their combination in the early prediction of sepsis-induced AKI. METHODS: A prospective cohort study was performed in septic patients. The variables potentially associated with AKI were recorded at admission and compared between the AKI and non-AKI groups. The variables independently associated with sepsis-induced AKI were identified using multivariable logistic regression, and the area under the receiver operating characteristic curve (AUROC) analysis was calculated...
March 16, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29568928/oral-supplementation-with-ursolic-acid-ameliorates-sepsis-induced-acute-kidney-injury-in-a-mouse-model-by-inhibiting-oxidative-stress-and-inflammatory-responses
#7
Zhenyu Zhang, Hong Zhang, Rui Chen, Zhong Wang
Ursolic acid (UA) as a multiple bioactive native compound has recently been demonstrated to treat sepsis in animal models. However, the beneficial effects of UA in sepsis‑induced acute kidney injury (AKI) are not completely understood. In the present study, the effect of UA on sepsis‑induced AKI in cecal ligation and puncture (CLP) surgery mice was investigated. Renal histomorphological analysis was performed by hematoxylin and eosin staining. The expression of inflammatory markers in the kidney of septic mice was measured by reverse transcription‑quantitative polymerase chain reaction and western blotting...
March 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29568906/mir-124-mcp-1-signaling-pathway-modulates-the-protective-effect-of-itraconazole-on-acute-kidney-injury-in-a-mouse-model-of-disseminated-candidiasis
#8
Xiao-Yue Li, Yu-Qi Zhang, Gang Xu, Shao-Hong Li, Heng Li
Previous studies have indicated that monocyte chemoattractant protein-1 (MCP‑1), also referred to as C‑C motif chemokine ligand 2, has a significant role in the pathogenesis of sepsis, however, how microRNAs (miRs) contribute to this process remains to be fully elucidated. In the present study, using a mouse model of disseminated candidiasis, the renoprotective effect of itraconazole (ITR) and adenovirus‑delivered miR‑124 was investigated. The mice were treated with ITR (50 mg/kg) or transfected with miR‑124 mimics via tail‑vein injection 7 days prior to Candida albicans infection...
March 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29545882/pterostilbene-attenuates-acute-kidney-injury-in-septic-mice
#9
Yizi Xia, Ying Chen, Luming Tang, Zheng Wang, Yu Zheng
Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti-apoptotic and anti-inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29544198/short-chain-fatty-acid-acetate-ameliorates-sepsis-induced-acute-kidney-injury-by-inhibition-of-nadph-oxidase-signaling-in-t-cells
#10
Naif O Al-Harbi, Ahmed Nadeem, Sheikh F Ahmad, Moureq R Alotaibi, Abdullah F AlAsmari, Wael A Alanazi, Mohammad M Al-Harbi, Ahmad M El-Sherbeeny, Khalid E Ibrahim
Sepsis affects millions of people worldwide and is associated with acute kidney injury (AKI). Innate and adaptive immune cells have been shown to play an important role in AKI through release of various inflammatory mediators which include reactive oxidant species (ROS). Acetate, a short chain fatty acid produced by gut bacteria has anti-inflammatory properties and has also been shown to modulate oxidative stress in different immune cells. Effects of acetate have been shown to be both GPR43 dependent and independent in different cells/tissues...
March 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29537312/a-zebrafish-model-of-infection-associated-acute-kidney-injury
#11
Xiaoyan Wen, Liyan Cui, Seth Morrisroe, Donald Maberry, David R Emlet, Simon C Watkins, Neil A Hukriede, John A Kellum
Sepsis-associated acute kidney injury (S-AKI) independently predicts mortality among critically ill patients. The role of innate immunity in this process is unclear, and there is an unmet need for S-AKI models to delineate the pathophysiological response. Mammals and zebrafish (Danio rerio) share a conserved nephron structure and homologous innate immune systems, making the latter suitable for sepsis-associated AKI research. We introduced Edwardsiella tarda (E.tarda) to the zebrafish. Systemic E. tarda bacteremia resulted in sustained bacterial infection and dose-dependent mortality...
March 14, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29497318/klotho-ameliorates-sepsis-induced-acute-kidney-injury-but-is-irrelevant-to-autophagy
#12
Xinxin Chen, Huan Tong, Yu Chen, Chaosheng Chen, Jingjing Ye, Qingfei Mo, Guangju Zhao, Guangliang Hong, Chenfei Zheng, Zhongqiu Lu
Background: The role of Klotho (KL) in sepsis-induced acute kidney injury (AKI) and the potential relationship between KL and autophagy in septic AKI were investigated. Materials and methods: A murine model of sepsis-induced AKI was established by cecal ligation and puncture (CLP). Mice undergoing CLP and immortalized proximal tubular epithelial human HK-2 cells that were exposed to lipopolysaccharide (LPS) were treated with recombinant KL, autophagy stimulator rapamycin (Rap), and autophagy suppressor 3-methyladenine (3-MA)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29489737/effects-of-clonidine-on-the-cardiovascular-renal-and-inflammatory-responses-to-experimental-bacteremia
#13
Paolo Calzavacca, Lindsea C Booth, Yugeesh R Lankadeva, Simon R Bailey, Louise M Burrell, Michael Bailey, Rinaldo Bellomo, Clive N May
INTRODUCTION: Supra-clinical doses of clonidine appear beneficial in experimental sepsis, but there is limited understanding of the effects of clonidine at clinically relevant doses. METHODS: In conscious sheep, with implanted renal and pulmonary artery flow probes, sepsis was induced by infusion of live Escherichia coli. At 24 hours, a high clinical dose of clonidine (HCDC) [1.0 μg/kg/h], a low clinical dose of clonidine (LCDC) [0.25 μg/kg/h] or vehicle, was infused for 8 hours...
February 27, 2018: Shock
https://www.readbyqxmd.com/read/29448207/ferulic-acid-protects-lipopolysaccharide-induced-acute-kidney-injury-by-suppressing-inflammatory-events-and-upregulating-antioxidant-defenses-in-balb-c-mice
#14
Salma Mukhtar Mir, Halley Gora Ravuri, Raj Kumar Pradhan, Sairam Narra, Jerald Mahesh Kumar, Madhusudana Kuncha, Sanjit Kanjilal, Ramakrishna Sistla
Sepsis-induced acute kidney injury (AKI) is responsible for 70-80% mortality in intensive care patients due to elevated levels of endotoxin, Lipopolysaccharide (LPS) caused by gram-negative infections. Ferulic acid (FA), a phenolic phytochemical is known for its renal protection on various induced models of nephrotoxicity. However, the curative effect of FA in LPS-induced AKI is not well studied. This study aimed to investigate the effect of FA on LPS-induced AKI in mice model and to understand the protective mechanisms involved, to provide evidence for FA in the treatment of AKI...
February 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29402367/-continuous-contrast-enhanced-ultrasound-applied-to-acute-kidney-injury-caused-by-sepsis-a-diagnostic-clinical-study
#15
Junyi Wang, Xinjing Gao, Dong Wang, Zhiyong Wang, Zhibo Li, Dong Liu, Lei Xu
OBJECTIVE: To evaluate the diagnostic value of contrast-enhanced ultrasound in acute kidney injury (AKI) caused by sepsis. METHODS: The sepsis patients admitted to intensive care unit of Tianjin Third Central Hospital from January 2015 to June 2017 were enrolled. All of the patients were completed the 6-hour Bundle treatment and the bilateral renal contrast-enhanced ultrasound within 24 hours, and the peak signal intensity (PSI), peak intensity time (PIT), wash internal rate (WIR) and renal function parameters were measured at the same time...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29395333/erythropoietin-induces-bone-marrow-and-plasma-fibroblast-growth-factor-23-during-acute-kidney-injury
#16
Luis Toro, Víctor Barrientos, Pablo León, Macarena Rojas, Magdalena Gonzalez, Alvaro González-Ibáñez, Sebastián Illanes, Keigo Sugikawa, Néstor Abarzúa, César Bascuñán, Katherine Arcos, Carlos Fuentealba, Ana María Tong, Alvaro A Elorza, María Eugenia Pinto, Rodrigo Alzamora, Carlos Romero, Luis Michea
It is accepted that osteoblasts/osteocytes are the major source for circulating fibroblast growth factor 23 (FGF23). However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in bone marrow and potential contribution to circulating FGF23 has not been well studied. Moreover, recent studies show that plasma FGF23 may increase early during acute kidney injury (AKI). Erythropoietin, a kidney-derived hormone that targets erythropoietic cells, increases in AKI. Here we tested whether an acute increase of plasma erythropoietin induces FGF23 expression in erythropoietic cells of bone marrow thereby contributing to the increase of circulating FGF23 in AKI...
January 27, 2018: Kidney International
https://www.readbyqxmd.com/read/29370574/the-protective-effect-of-ticagrelor-on-renal-function-in-a-mouse-model-of-sepsis-induced-acute-kidney-injury
#17
Xiuhua Li, Yusheng Li, Kan Shen, Hongqiang Li, Jianwen Bai
Platelets are traditionally considered to be essential components of primary hemostasis. Recent investigations have revealed that platelets can be activated in patients with sepsis and are implicated in the development of sepsis and sepsis-induced-acute kidney injury (SAKI). In the present study, ticagrelor was used to induce a mouse model of SAKI by cecal ligation and puncture. It was found that ticagrelor could inhibit platelet activity, decrease the levels of interleukin-1β and serum creatinine, reduce infiltration of neutrophils in renal tissue, and attenuate cell apoptosis in the kidney...
January 25, 2018: Platelets
https://www.readbyqxmd.com/read/29353206/dihydroartemisinin-ameliorates-sepsis-induced-hyperpermeability-of-glomerular-endothelium-via-up-regulation-of-occludin-expression
#18
Zuowang Cheng, Ruixia Qi, Liqun Li, Qiang Liu, Wenqian Zhang, Xia Zhou, Dongmei Xu, Thaddeus D Allen, Silin Pan, Ju Liu
Sepsis, the systemic inflammatory responses after infection, remains a serious cause of morbidity and mortality in critically ill patients. The anti-malarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we examined the effects of DHA on sepsis-induced acute kidney injury (AKI) and explored the mechanism underlying its mode of action in AKI. In a lipopolysaccharide (LPS)-induced mouse model, we observed that DHA treatment ameliorated glomerular injury, and relieved elevation of the urine albumin to creatinine ratio (UACR) and serum creatinine...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29348412/influence-of-autophagy-on-acute-kidney-injury-in-a-murine-cecal-ligation-and-puncture-sepsis-model
#19
Satoshi Sunahara, Eizo Watanabe, Masahiko Hatano, Paul E Swanson, Takehiko Oami, Lisa Fujimura, Youichi Teratake, Takashi Shimazui, Chiwei Lee, Shigeto Oda
The role of autophagy in the maintenance of renal homeostasis during sepsis is not well understood. We therefore aimed to determine the influence of autophagy on kidney during sepsis using a murine sepsis model, i.e. cecal ligation and puncture (CLP). In CLP treated animals, the number of autolysosomes observed by electron microscopy increased over time. The number of autophagosomes in CLP animals decreased relative sham operated controls at 24 hrs after CLP, indicating that autophagy flux is already diminishing by that time...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334583/effects-of-carnosine-beta-alanyl-l-histidine-in-an-experimental-rat-model-of-acute-kidney-injury-due-to-septic-shock
#20
Sabiha Sahin, Dilek Burukoglu Donmez
BACKGROUND Acute kidney injury (AKI) secondary to sepsis is a major cause of morbidity and mortality in the human intensive care unit (ICU). Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine). MATERIAL AND METHODS Twenty-four Sprague-Dawley rats were randomly divided into three groups consisting eight rats in each: Group 1 - control; Group 2 - septic shock; and Group 3 - septic shock treated with carnosine...
January 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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