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https://www.readbyqxmd.com/read/28635907/-the-problem-of-obstructive-sleep-apnea-syndrome-in-asthmatic-patients
#1
E G Sheludko, D E Naumov, Yu M Perelman, V P Kolosov
Asthma and obstructive sleep apnea syndrome (OSAS) are one of the most common chronic respiratory diseases. These have common risk factors that include obesity, gastroesophageal reflux disease (GERD) and impaired nasal breathing (allergic rhinitis, sinusitis). At the same time, experimental evidence demonstrates common pathophysiological mechanisms of these diseases, such as involvement in the process of the respiratory tract, a systemic inflammatory response, and implementation of neuromechanical reflexes...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28625008/the-role-of-local-allergy-in-the-nasal-inflammation
#2
REVIEW
Ke-Jia Cheng, Min-Li Zhou, Ying-Ying Xu, Shui-Hong Zhou
Local allergic inflammation (LAI) is recognized recently. 'entopy' was used to define LAI, which was positively correlated with allergen provocation testing, local sIgE up-regulation, inflammatory mediator secretion, and a lack of systemic allergy. The study of LAI is in its infancy and focuses mainly on the respiratory system. It is closely related to nasal inflammation and plays important roles in patients with nonallergic rhinitis (NAR), nonallergic chronic sinusitis with nasal polyps (CRSwNP), and nonallergic fungal rhinosinusitis (NAFRS)...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28610682/menopausal-hormone-therapy-may-increase-non-allergic-rhinitis-among-postmenopausal-women-results-from-the-korea-national-health-and-nutrition-examination-survey-2010-2012
#3
Ji Ho Choi, Se Hwan Hwang, Jeffrey D Suh, Jin Kook Kim, Seok-Chan Hong, Young Chang Lim, Soo-Nyung Kim, Jae Hoon Cho
OBJECTIVES: To investigate the association between menopausal hormone therapy (MHT) and chronic rhinitis. METHODS: The data used in this study were derived from the Korea National Health and Nutrition Examination Survey. The analysis included 2967 postmenopausal women under 70 years of age, and there were no missing data. Questionnaire responses regarding MHT, current life habits, reproductive history, and rhinitis were reviewed. The levels of total immunoglobulin E (IgE) and specific IgE for Dermatophagoides farinae, cockroaches, and dogs were measured, using approximately 10% of all samples...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28608749/polypoid-change-of-the-middle-turbinate-and-paranasal-sinus-polyposis-are-distinct-entities
#4
Jacob P Brunner, Basit A Jawad, Edward D McCoul
Objectives Polypoid change of the middle turbinate (PCMT) is a finding on intranasal examination whose significance is not well understood. We present a comparison of the clinical characteristics of PCMT with paranasal sinus polyposis (PSP), a common condition with potentially similar appearance. Study Design Parallel case series. Setting Tertiary rhinology clinic. Subjects and Methods Data were prospectively compiled from consecutive patients during a 12-month period with either PSP arising from the middle meatus or PCMT limited to the middle turbinate as identified on nasal endoscopy...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607533/cysteinyl-leukotrienes-as-potential-pharmacological-targets-for-cerebral-diseases
#5
REVIEW
Paolo Gelosa, Francesca Colazzo, Elena Tremoli, Luigi Sironi, Laura Castiglioni
Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader range of inflammation-associated diseases such as cancer, atopic dermatitis, rheumatoid arthritis, and cardiovascular diseases. The reported elevated levels of CysLTs in acute and chronic brain lesions, the association between the genetic polymorphisms in the LTs biosynthesis pathways and the risk of cerebral pathological events, and the evidence from animal models link also CysLTs and brain diseases...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28587510/effects-of-fluticasone-furoate-nasal-spray-on-parameters-of-eosinophilic-inflammation-in-patients-with-nasal-polyposis-and-perennial-allergic-rhinitis
#6
Cveta Špadijer Mirković, Aleksandar Perić, Biserka Vukomanović Đurđević, Danilo Vojvodić
OBJECTIVES: Regulated on activation normal T cell expressed and secreted (RANTES) and eotaxin-2 have been postulated to be responsible for eosinophilia in chronically inflamed nasal mucosa. This study evaluated mucosal production of RANTES and eotaxin-2 in patients with perennial allergic rhinitis (PAR) and nonallergic and allergic form of chronic rhinosinusitis with nasal polyps (CRSwNP) before and after nasal corticosteroid treatment. METHODS: Twenty patients with PAR, 20 nonallergic and 20 allergic CRSwNP patients, and 20 healthy controls were included...
June 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28585360/functional-and-phenotypic-analysis-of-basophils-allows-determining-distinct-subtypes-in-patients-with-chronic-urticaria
#7
Michèle Myriam Rauber, Julia Pickert, Lily Holiangu, Christian Möbs, Wolfgang Pfützner
BACKGROUND: Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pruritic hives. While clinical symptoms are due to the release of histamine by cutaneous mast cells, the underlying pathophysiology is still unknown. However, previous studies indicate that basophils might be of relevance. Besides, the occurrence of autoantibodies against IgE or its receptor, FcεRI, and the therapeutic efficacy of anti-IgE antibodies imply that IgE-mediated mechanisms also play an important role in CU...
June 5, 2017: Allergy
https://www.readbyqxmd.com/read/28583485/demographics-and-clinical-features-predictive-of-allergic-versus-non-allergic-rhinitis-in-children-aged-6-18-years-a-single-center-experience-of-1535-patients
#8
Ignazio La Mantia, Claudio Andaloro
BACKGROUND: Chronic rhinitis (CR) is one of the most common causes accounting for lost-school days, absenteeism and resource utilization in pediatric patients. Distinction between common causes of CR, allergic (AR)and non-allergic rhinitis (NAR), based upon clinical features is critical, especially in primary care settings or facilities with lack of allergen sensitivity testing, as management strategies differ considerably. The current study elucidates clinical factors, particularly facial features associated with AR and NAR using a large cohort...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28572918/multi-morbidities-of-allergic-rhinitis-in-adults-european-academy-of-allergy-and-clinical-immunology-task-force-report
#9
REVIEW
C Cingi, P Gevaert, R Mösges, C Rondon, V Hox, M Rudenko, N B Muluk, G Scadding, F Manole, C Hupin, W J Fokkens, C Akdis, C Bachert, P Demoly, J Mullol, A Muraro, N Papadopoulos, R Pawankar, P Rombaux, E Toskala, L Kalogjera, E Prokopakis, P W Hellings, J Bousquet
This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28565855/immunosuppressive-effect-of-sinomenine-in-an-allergic-rhinitis-mouse-model
#10
Zhe Chen, Ze-Zhang Tao, Xu-Hong Zhou, Ting-Ting Wu, Lin-Feng Ye
Allergic rhinitis (AR) is a chronic allergic airway disease that has become a significant global public health issue. Sinomenine (SN), a natural phytochemical found in Sinomenium acutum, showed anti-inflammatory and immunosuppressive effect in previous studies. In order to explore the role of SN in the treatment of AR, mice were sensitized and challenged by ovalbumin (OVA) to establish an AR mouse model. SN was administered to AR mice orally, and compared with dexamethasone treatment as a positive control. Nasal symptoms and histopathological changes were used to evaluate the effect of SN treatment in the AR mice model...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28549211/chronic-sinonasal-tract-inflammation-as-a-precursor-to-nasopharyngeal-carcinoma-and-sinonasal-malignancy-in-the-united-states
#11
Eric L Wu, Charles A Riley, Mei-Chin Hsieh, Michael J Marino, Xiao-Cheng Wu, Edward D McCoul
BACKGROUND: Chronic inflammatory states have been linked to the development of malignancy. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) have been associated with nasopharyngeal carcinoma (NPC) in population-based studies in Asia. A similar association with NPC and paranasal sinus malignancy (PSM) has not been defined in a North American population. Our purpose was to investigate the impact of CRS and AR on the risk of NPC and PSM. METHODS: The Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database was queried as a case-control study of adults ≥65 years of age...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544688/prolonged-denervation-induces-remodeling-of-nasal-mucosa-in-rat-model-of-posterior-nasal-neurectomy
#12
Hironobu Nishijima, Kenji Kondo, Makiko Toma-Hirano, Shu Kikuta, Mizuo Ando, Rumi Ueha, Tatsuya Yamasoba
BACKGROUND: The posterior nasal nerve is the dominant source of the parasympathetic, sympathetic, and sensory fibers that innervate the nasal respiratory mucosa. Therefore, a posterior nasal neurectomy (PNN) induces denervation of the nasal mucosa and relieves the nasal symptoms of intractable rhinitis. PNN depletes nerve fibers, choline acetyltransferase, and neuropeptides in nasal respiratory mucosa, and reduces nasal secretion. However, the histological and symptomatic changes over an extended period after PNN remain unknown...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28533689/medication-related-costs-of-rhinitis-in-australia-a-nostradata-cross-sectional-study-of-pharmacy-purchases
#13
Pete Smith, David Price, Richard Harvey, Andrew Simon Carney, Vicky Kritikos, Sinthia Z Bosnic-Anticevich, Louise Christian, Derek Skinner, Victoria Carter, Alice Marie Sybille Durieux
PURPOSE: There is a relative paucity of research regarding medication expenditure associated with multiple-therapy use for rhinitis in Australia. To describe 1) the nature and extent of multiple-therapy use for rhinitis in Australia using data on therapies purchased with prescription or over-the-counter (OTC) and 2) additional costs incurred by multiple-therapy use compared with intranasal corticosteroid (INCS) therapy alone. PATIENTS AND METHODS: A retrospective observational study was carried out using a database containing anonymous pharmacy transaction data available from 20% of pharmacies in Australia that links doctor prescriptions and OTC purchase information...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28532268/allergen-immunotherapy-in-allergic-rhinitis-current-use-and-future-trends
#14
Ludger Klimek, Oliver Pfaar, Jean Bousquet, Gabriela Senti, Thomas Kündig
Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT...
June 15, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28532204/management-of-allergic-rhinitis-in-the-era-of-effective-over-the-counter-treatments
#15
Warner W Carr, Barbara P Yawn
Allergic rhinitis (AR) may be regarded as a trivial issue unworthy of the doctor's time, and with the availability of many different over-the-counter (OTC) treatments, up to two thirds of patients self-manage AR before seeking medical care. Yet, AR can have a significant impact on health-related quality of life and is associated with a greater detriment to work productivity than other chronic diseases such as diabetes and hypertension. For many patients, the impact on quality of life is greater than suggested by reported symptoms and should also be a focus of treatment...
June 9, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#16
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28526889/the-contribution-of-an-asthma-diagnostic-consultation-service-in-obtaining-an-accurate-asthma-diagnosis-for-primary-care-patients-results-of-a-real-life-study
#17
R M E Gillis, W van Litsenburg, R H van Balkom, J W Muris, F W Smeenk
Previous studies showed that general practitioners have problems in diagnosing asthma accurately, resulting in both under and overdiagnosis. To support general practitioners in their diagnostic process, an asthma diagnostic consultation service was set up. We evaluated the performance of this asthma diagnostic consultation service by analysing the (dis)concordance between the general practitioners working hypotheses and the asthma diagnostic consultation service diagnoses and possible consequences this had on the patients' pharmacotherapy...
May 19, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28521324/the-role-of-hydrolyzed-formula-in-allergy-prevention
#18
Michael D Cabana
Asthma, eczema, food allergy, and allergic rhinitis are some of the most common pediatric, chronic conditions in the world. Breastfeeding is the optimal way to feed all infants. For those infants who are exposed to infant formula, some studies suggest that certain partially hydrolyzed or extensively hydrolyzed formulas may decrease the risk of allergic disease compared to nonhydrolyzed formulas for children with a family history of atopic disease. Overall, there is some evidence to suggest that partially hydrolyzed whey formulas and extensively hydrolyzed casein formulas may decrease the risk of developing eczema for infants at high risk of allergic disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28518004/middle-ear-barotrauma-in-student-pilots
#19
Jung Heob Sohn, Kyoung Rai Cho
INTRODUCTION: The present study reports the clinical features of middle ear barotrauma in student pilots in the Republic of Korea Air Force. METHODS: The authors reviewed medical records of student pilots with barotrauma. The grade of barotrauma was assigned using Teed's classification. This study included nasal symptoms, endoscopic findings of the nasal cavity, and clinical course (duration, recurrence). The relationship between middle ear barotrauma and the nasal airway was also evaluated...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28513250/combined-measurements-of-fractional-exhaled-nitric-oxide-and-nasal-nitric-oxide-levels-for-assessing-upper-airway-diseases-in-asthmatic-patients
#20
Takamitsu Asano, Masaya Takemura, Yoshihiro Kanemitsu, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Hisatoshi Hijikata, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Atsushi Nakamura, Yumi Maki, Yoshihisa Nakamura, Motohiko Suzuki, Akio Niimi
BACKGROUND: Despite the close linkage between rhinitis, chronic rhinosinusitis (CRS) and asthma, relevant biomarkers of both upper and lower airway inflammation are rare. METHODS: Patients with asthma (without upper airway disease [UAD; n = 24], with rhinitis [n = 25], CRS [n = 24], and nasal polyps [n = 2]), isolated rhinitis (n = 13), isolated CRS (n = 13), and 10 healthy controls were prospectively recruited. Fractional exhaled nitric oxide (NO) levels at 50 mL/s (FeNO50), nasal NO levels, Lund-Macay-scores of sinus computed tomography and an asthma control questionnaire (ACQ) were evaluated...
May 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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