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https://www.readbyqxmd.com/read/29133218/cluster-analysis-identifies-3-phenotypes-within-allergic-asthma
#1
María Paz Sendín-Hernández, Carmelo Ávila-Zarza, Catalina Sanz, Asunción García-Sánchez, Elena Marcos-Vadillo, Francisco J Muñoz-Bellido, Elena Laffond, Christian Domingo, María Isidoro-García, Ignacio Dávila
BACKGROUND: Asthma is a heterogeneous chronic disease with different clinical expressions and responses to treatment. In recent years, several unbiased approaches based on clinical, physiological, and molecular features have described several phenotypes of asthma. Some phenotypes are allergic, but little is known about whether these phenotypes can be further subdivided. OBJECTIVE: We aimed to phenotype patients with allergic asthma using an unbiased approach based on multivariate classification techniques (unsupervised hierarchical cluster analysis)...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29122078/the-role-of-regulatory-t-cells-in-the-regulation-of-upper-airway-inflammation
#2
Charlie Palmer, Jennifer K Mulligan, Sarah E Smith, Carl Atkinson
Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are inflammatory diseases of the upper airway, with a similar immunologic profile, characterized by aberrant and persistent type 2 inflammation. One cell population that has been identified as altered in both disease types is regulatory T cell (Treg). Tregs have the capacity to modulate T-effector function and suppress inflammatory cytokine production in a broad range of cell types. Given the ability of Tregs to control inflammation, the role of Tregs in respiratory diseases has attracted much attention...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29116046/radon-enriched-hot-spring-water-therapy-for-upper-and-lower-respiratory-tract-inflammation
#3
Desiderio Passali, Giacomo Gabelli, Giulio Cesare Passali, Ralph Mösges, Luisa Maria Bellussi
Background Radon-222-enriched hot spring therapy, which is characterized by a safe level of radioactivity, is used for the treatment of rheumatic disorders, and its efficacy has already been studied in several clinical trials. Radon-water inhalation therapy for the treatment of upper and lower airway inflammatory diseases is used in many hot springs centers. However, its application has not been reviewed to date. Methods We systematically searched the PubMed and Scopus databases for clinical trials published in the last 20 years in which objective parameters of upper and lower airway function had been tested before and after radon-enriched inhalation treatment...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29103416/inhibitory-effect-of-phlai-capsules-on-skin-test-responses-among-allergic-rhinitis-patients-a-randomized-three-way-crossover-study
#4
Pattara Tanticharoenwiwat, Prapasri Kulalert, Thaweephol Dechatiwongse Na Ayudhya, Sittichai Koontongkaew, Weena Jiratchariyakul, Ruedee Soawakontha, Prakongsiri Booncong, Orapan Poachanukoon
BACKGROUND: Zingiber cassumunar Roxb., commonly known as Phlai in Thai, has been used as a traditional medicine in Thailand for the treatment of various diseases, including inflammation and chronic airway disease. OBJECTIVE: The purpose of this study was to assess the antihistaminic effect of Phlai on skin testing. DESIGN, SETTING, PARTICIPANTS AND INTERVENTION: This was a randomized, open-label, three-way crossover study. Twenty allergic rhinitis (AR) patients were enrolled...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29094017/frequency-and-effect-of-type-1-hypersensitivity-in-patients-from-india-with-chronic-obstructive-pulmonary-disease-and-associated-upper-airways-symptoms
#5
Avi Kumar, Shekhar Kunal, Ashok Shah
Background: Chronic obstructive pulmonary disease (COPD) is now recognized as a systemic disorder with many comorbidities. Atopy in patients with COPD and upper airways symptoms has not been characterized. Objective: We investigated the occurrence and impact of aeroallergen sensitisation in patients with COPD and upper airways symptoms. Methods: All 41 subjects with COPD diagnosed as per Global Initiative for Chronic Obstructive Lung Disease guidelines, underwent spirometry with reversibility, computed tomography of the paranasal sinuses (CT-PNS), skin prick test (SPT) against common aeroallergens and responded to St...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29084018/assessing-patient-reported-outcomes-in-asthma-and-copd-patients-which-can-be-recommended-in-clinical-practice
#6
Janwillem W H Kocks, Sven F Seys, Titia S van Duin, Zuzana Diamant, Ioanna G Tsiligianni
PURPOSE OF REVIEW: There is a clear need for simple and reliable patient-reported outcome measures for chronic obstructive pulmonary disease (COPD) and asthma in daily practice. The purpose of this review is to facilitate the choice for clinicians of patient-reported outcomes which they can use in their daily practice. RECENT FINDINGS: More than 50 patient-reported outcome measures for asthma and COPD exist and clinicians are often left confused on which to use...
October 27, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29075437/chrodis-criteria-applied-to-the-mask-macvia-aria-sentinel-network-good-practice-in-allergic-rhinitis-a-sunfrail-report
#7
REVIEW
J Bousquet, G L Onorato, C Bachert, M Barbolini, A Bedbrook, L Bjermer, J Correia de Sousa, N H Chavannes, A A Cruz, E De Manuel Keenoy, P Devillier, J Fonseca, S Hun, T Kostka, P W Hellings, M Illario, J C Ivancevich, D Larenas-Linnemann, J Millot-Keurinck, D Ryan, B Samolinski, A Sheikh, A Yorgancioglu, I Agache, S Arnavielhe, M Bewick, I Annesi-Maesano, J M Anto, K C Bergmann, C Bindslev-Jensen, S Bosnic-Anticevich, J Bouchard, D P Caimmi, P Camargos, G W Canonica, V Cardona, A M Carriazo, C Cingi, E Colgan, A Custovic, R Dahl, P Demoly, G De Vries, W J Fokkens, J F Fontaine, B Gemicioğlu, N Guldemond, Z Gutter, T Haahtela, B Hellqvist-Dahl, E Jares, G Joos, J Just, N Khaltaev, T Keil, L Klimek, M L Kowalski, I Kull, P Kuna, V Kvedariene, D Laune, R Louis, A Magnan, J Malva, E Mathieu-Dupas, E Melén, E Menditto, M Morais-Almeida, R Mösges, J Mullol, R Murray, H Neffen, R O'Hehir, S Palkonen, N G Papadopoulos, G Passalacqua, J L Pépin, F Portejoie, D Price, B Pugin, F Raciborski, F E R Simons, M Sova, O Spranger, C Stellato, A Todo Bom, P V Tomazic, M Triggiani, A Valero, E Valovirta, O VandenPlas, A Valiulis, M van Eerd, M T Ventura, M Wickman, I Young, T Zuberbier, A Zurkuhlen, A Senn
A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29063426/introduction
#8
Erica A Fortson, Becky Li, Mahima Bhayana
Atopic dermatitis (AD) is a chronic relapsing condition that is characterized by itching and redness of the skin. Our modern usage of atopic dermatitis dates back to 1933, when Wise and Sulzberger first coined the term to signify the disease's close association with other respiratory atopy, such as bronchial asthma and allergic rhinitis. A recent systematic review of 69 cross-sectional and cohort studies has confirmed that AD is now a worldwide phenomenon with lifetime AD prevalences of well over 20% in many affluent country settings...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29031394/the-role-of-cysteinyl-leukotrienes-and-their-receptors-in-refractory-nasal-polyps
#9
Jintao Du, Luo Ba, Jiao Zhou, Lingyu Yu, Ruowu Liu, Jie Zhang, Feng Liu, Junming Xian, Shixi Liu, Yafeng Liu
Leukotriene signaling is essential in many diseases, including asthma, allergic rhinitis, atherosclerosis and inflammatory bowel disease. Nevertheless, the expression of cysteinyl leukotrienes (CysLTs) and its receptors (CYSLTRs) in different types of nasal polyps (NPs), and the role of their antagonist in the treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) are not well understood. The following study investigates the expression of CysLTs and CYSLTRs in different types of NPs, as well as the role of leukotriene receptor antagonist (montelukast) in refractory NPs...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29028686/interaction-between-catalase-gene-promoter-polymorphisms-and-indoor-environmental-exposure-in-childhood-allergic-rhinitis
#10
Hsin-I Chen, Yu-Ting Lin, Chau-Ren Jung, Bing-Fang Hwang
BACKGROUND: Allergic rhinitis (AR) is a highly prevalent chronic inflammatory disease affecting nearly 40% of the children in Taiwan. Genetic susceptibility may interact with specific environmental factors leading to allergic disease development. METHODS: To assess the interactions between catalase gene promoter polymorphisms and environmental factors on the risk of AR, we conducted a case-control study in Taiwan. Data on AR and environmental factors were collected from 800 children using the ISSAC questionnaire...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29022093/-seasonal-allergic-conjunctivitis
#11
K Schröder, D Finis, S Meller, M Wagenmann, G Geerling, U Pleyer
Seasonal allergic conjunctivitis (SAC) is a frequent disease, which is often associated with allergic rhinitis and subsequently manifested as allergic rhinoconjunctivitis. In contrast to other types of chronic allergic conjunctivitis, the course of SAC is not sight-threatening. Pathogenetically, the underlying cause of SAC is an immunoglobulin E (IgE) mediated, Th2-driven type 1 hypersensitivity reaction. Clinically it presents with itching, light-red conjunctival injection as well as chemosis that exceeds the extent of conjunctival injection...
November 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29017524/chronic-obstructive-pulmonary-disease-bronchial-asthma-and-allergic-rhinitis-in-the-adult-population-within-the-commonwealth-of-independent-states-rationale-and-design-of-the-core-study
#12
Yuriy Feshchenko, Liudmila Iashyna, Damilya Nugmanova, Olga Gyrina, Marina Polyanskaya, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S Pereira, Elcan Mammadbayov, Irada Akhundova, Averyan Vasylyev
BACKGROUND: Main treatable Chronic Respiratory Diseases (CRDs) like Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma (BA) and Allergic Rhinitis (AR) are underdiagnosed and undertreated worldwide. CORE study was aimed to assess the point prevalence of COPD, BA and AR in the adult population of major cities of Commonwealth of Independent States (CIS) countries - Azerbaijan, Kazakhstan, and Ukraine based on study questionnaires and/or spirometry, and to document risk factors, characterize the COPD, BA and AR population to provide a clearer "epidemiological data"...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28990844/impact-of-nasal-conditions-on-chronic-otitis-media-a-cross-sectional-study-in-koreans
#13
Kyung Wook Heo, Min Jae Kim, Jun Ho Lee
OBJECTIVES: We evaluated the relationship between pathological nasal conditions and pathological middle ear conditions on a large-scale epidemiological basis, conducted as a cross-sectional study at the population level using Korean National Health and Nutrition Examination Survey (KNHANES) data. STUDY DESIGN: A cross-sectional study. METHODS: In a retrospective cohort study, we analyzed data from the KNHANES (2008-2012), which used a stratified, multi-stage, probability-cluster sampling method in a rolling sampling survey of South Korean citizens...
October 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28988813/asthma-management-for-the-otolaryngologist
#14
REVIEW
John H Krouse
Asthma is a chronic inflammatory disease that will frequently be encountered by otolaryngologists as they manage their patients with upper respiratory diseases. Symptoms such as cough should alert otolaryngologists to consider more broadly the potential role of asthma in the differential diagnosis. It is critical for otolaryngologists to appreciate that patients with allergic rhinitis and chronic rhinosinusitis will often have asthma, and that many of them may not be diagnosed at the time of presentation. Appropriate diagnosis of the patient with asthma, as well as effective treatment for its symptoms, will improve patient function and enhance quality of life...
December 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28983950/epidemiology-and-comorbidities-of-patients-with-chronic-urticaria-in-korea-a-nationwide-population-based-study
#15
Bo Ri Kim, Seungkeol Yang, Jee Woong Choi, Chong Won Choi, Sang Woong Youn
Few population-based studies have focused on the epidemiology and comorbidities of chronic urticaria (CU) or chronic spontaneous urticaria (CSU). The objective of this study was to obtain information on the epidemiology and comorbidities associated with CU and CSU in Korea. We conducted a cross-sectional analysis using a national health insurance database. An algorithm based on the International Classification of Diseases, 10th revision, was used for the identification of patients with CU and CSU, and an age-sex adjusted logistic regression model was used to assess the risk of comorbidities in these patients...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28983485/anti-ige-treatment-for-disorders-other-than-asthma
#16
REVIEW
Jeffrey Stokes
Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28975430/clinical-assessment-of-diode-laser-assisted-endoscopic-intrasphenoidal-vidian-neurectomy-in-the-treatment-of-refractory-rhinitis
#17
Wen-Sen Lai, Sheng-Yao Cheng, Yuan-Yung Lin, Pei-Lin Yang, Hung-Che Lin, Li-Hsiang Cheng, Jinn-Moon Yang, Jih-Chin Lee
For chronic rhinitis that is refractory to medical therapy, surgical intervention such as endoscopic vidian neurectomy (VN) can be used to control the intractable symptoms. Lasers can contribute to minimizing the invasiveness of ENT surgery. The aim of this retrospective study is to compare in patients who underwent diode laser-assisted versus traditional VN in terms of operative time, surgical field, quality of life, and postoperative complications. All patients had refractory rhinitis with a poor treatment response to a 6-month trial of corticosteroid nasal sprays and underwent endoscopic VN between November 2006 and September 2015...
December 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28964532/contemporary-pharmacotherapy-for-allergic-rhinitis-and-chronic-rhinosinusitis
#18
REVIEW
Saied Ghadersohi, Bruce K Tan
Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are chronic conditions causing nasal inflammation. CRS is increasingly recognized as a chronic inflammatory process rather than a chronic infection. Although the primary initiating factors in CRS remain unclear, AR is driven by IgE-mediated hypersensitivity to environmental allergens. Understanding the underlying inflammatory pathways and disease endotypes are driving innovation toward novel pharmacotherapies targeting critical mediators implicated in CRS and AR, including IL-4, IL-13, IL-5, IgE, and epithelial initiators IL-33 and TSLP...
September 27, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28954471/dust-exposure-and-health-of-workers-in-duck-hatcheries
#19
Marie-Thérèse Guillam, Sylvie Martin, Marine Le Guelennec, Julie Puterflam, Sophie Le Bouquin, Adeline Huneau-Salaün
OBJECTIVES: The objectives of this cross-sectional study were to investigate dust exposure and respiratory health of workers in duck hatcheries in western France. MATERIAL AND METHODS: Ninety volunteer workers, who work in sorting rooms and/or incubation rooms, participated in exposure assessments and medical examinations. Medical examinations were performed by occupational health practitioners.They filled-in a questionnaire with the workers, followed by a lung function test on each worker...
July 4, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28926718/corrigendum
#20
(no author information available yet)
Brunner JP, Jawad BA, McCoul ED. Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities. Otolaryngol Head Neck Surg. 2017;157:519-523. (Original doi: 10.1177/0194599817711887) The Results section of this article and its abstract contained several errors in describing data that appears in Tables 1 and 2. The tables contain the correct information, the corrected abstract and article text appears below. Abstract: Results. Of 593 patients, 23 (3.9%) had PCMT and 44 (7.4%) had PSP...
September 1, 2017: Otolaryngology—Head and Neck Surgery
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