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https://www.readbyqxmd.com/read/29775027/-clinical-research-of-different-characteristics-of-fungal-ball-sinusitis
#1
M J Wang, B Zhou, Y C Li, S J Cui, Q Huang
Objective: The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Method: Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Result: In this retrospective study, 449 patients who diagnosed with fungal ball sinusitis were involved...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#2
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29751756/prevalence-of-asthma-among-the-adult-general-population-of-five-middle-eastern-countries-results-of-the-snapshot-program
#3
Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. METHODS: SNAPSHOT is a cross-sectional epidemiological program carried out in five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia, and the United Arab Emirates, the latter three grouped into a Gulf cluster) to collect data on asthma, allergic rhinitis, benign prostatic hyperplasia and bipolar disorder...
May 11, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29751088/integrated-behavioral-health-care-for-management-of-stress-in-allergic-diseases
#4
REVIEW
Alyssa Oland, Genery D Booster, Bruce G Bender
OBJECTIVE: The present article will review current findings regarding the management of stress in allergic disease. DATA SOURCES: The present review article uses articles and books published between 1995 and 2017. Approximately 85% of sources used were published in the last 10 years and 60% were published in the last 5 years. The majority of sources are peer-reviewed articles. STUDY SELECTIONS: Articles that focused on allergic diseases such as allergic rhinitis, food allergies, urticaria, and allergic asthma were included in the present review...
May 8, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29732293/skin-prick-test-reactivity-to-aeroallergens-in-adult-allergy-clinic-in-thailand-a-12-year-retrospective-study
#5
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
Background: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. Objective: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. Methods: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29730558/increased-expression-of-il-1r8-and-a-possible-immunomodulatory-role-of-its-ligand-il-37-in-allergic-rhinitis-patients
#6
Cong Li, Yang Shen, Jue Wang, Zu-Xia Ma, Xia Ke, Zhi-Hai Wang, Su-Ling Hong, Guo-Hua Hu
Allergic rhinitis (AR) is a chronic inflammatory airway disease that is caused by an abnormal T cell response. T helper (Th)-17 cells and Th2 cells are the CD4+ T cell subsets implicated in the pathogenesis of AR. The suppression of excessive responses of these Th17 and Th2 cells has been reported to be an effective therapeutic approach to treat AR patients, and continuous efforts are being undertaken to find new methods to modulate the function of these cells. Recent studies have shown that IL-1R8 and its ligand IL-37 negatively regulate the immune response...
May 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29719412/acute-effects-of-smoke-exposure-on-airway-and-systemic-inflammation-in-forest-firefighters
#7
Niki Gianniou, Charilena Giannakopoulou, Efrossini Dima, Matina Kardara, Paraskevi Katsaounou, Alexandros Tsakatikas, Charis Roussos, Nikolaos Koulouris, Nikoletta Rovina
Introduction: The aim of this study was to assess respiratory health and airway and systemic inflammation in professional forest firefighters post firefighting. Methods: A total of 60 firefighters who participated in forest firefighting operations in Greece during 2008 were included in the study. A questionnaire consisting of symptoms and exposure, pulmonary function, atopy, bronchial hyperresponsiveness, and markers of inflammation in induced sputum, serum, and bronchoalveolar lavage (BAL) fluid was assessed...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29714449/effect-of-mometasone-furoate-nasal-spray-on-the-dna-of-nasal-mucosal-cells
#8
Hakan Akkaş, Erdinç Aydın, Seda Türkoğlu Babakurban, Erkan Yurtcu, Özlem Yılmaz Özbek
Background/aim: Allergic rhinitis (AR) is a respiratory disease caused by inflammation of the nasal mucosa. Intranasal corticosteroids (ICs) are an effective treatment for AR; however, their use has been associated with atrophy in nasal mucosae. Because DNA damage has been linked to several chronic diseases, we hypothesize that use of ICs could cause DNA damage in nasal mucosa cells, leading to mucosal atrophy and septal perforation. Materials and methods: Sixty patients with moderate or severe AR were divided randomly into two groups...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29707116/the-role-of-particulate-matters-on-methylation-of-ifn-%C3%AE-and-il-4-promoter-genes-in-pediatric-allergic-rhinitis
#9
Youjin Li, Zhe Mu, Hongyang Wang, Jinfen Liu, Fan Jiang
Allergic rhinitis (AR) is a chronic inflammatory disorder driven by T cell activation. How particulate matter contributes to epigenetic changes that in turn influence cytokine gene expression in CD4+ T cells remains unclear. In this study, 105 children diagnosed with AR and 90 healthy controls were recruited to explore the possible mechanism of particulate matter (PM) on the epigenetic regulation of CD4+ T IFN-γ and IL-4 promoter genes. Daily average PM10 and PM2.5 were obtained from five state-controlled monitoring stations, and activity-based dynamic exposure and personal exposure data were collected...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29702735/effects-of-ugt1a1-cyp3a5-and-abcb1-genetic-variants-on-pharmacokinetics-of-antihistamine-drug-mizolastine-in-chinese-healthy-volunteers
#10
Pu Li, Min-Ji Wei, Zhi-Yuan Zhang, Sheng-Ju Yin, Xin Wang, Ya-Qing Lou, Zi-Sheng Kang, Yuan Lu, Xuan Wei, Suo-Di Zhai, Guo-Liang Zhang
Mizolastine is a selective histamine H1 receptor antagonist for chronic urticaria or allergic rhinitis. We investigated whether the variant genotypes of metabolic enzymes UGT1A1, CYP3A5 and transporter ABCB1 influence pharmacokinetic phenotype of substrate mizolastine in Chinese volunteers. Genotyping of single nucleotide polymorphisms (SNPs) in UGT1A1*6 (G211A), CYP3A5*3 (A6986G) and ABCB1 (C3435T) were determined by the pyrosequencing method. After a single oral dose of 10 mg mizolastine, the plasma concentrations were measured using validated high performance liquid chromatography (HPLC) in 24 Chinese healthy volunteers...
April 27, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29702281/intestinal-dysbacteriosis-potentiates-ovalbumin-induced-allergic-airway-inflammation-by-inhibiting-microrna-130a-to-upregulate-tumor-necrosis-factor-%C3%AE
#11
Lei Shi, Wei Yin, Zhiyu Zhang, Guanggang Shi
Allergic airway diseases (AAD), including chronic disorders such as allergic rhinitis, are resulted from complicated immunological interactions. Intestinal dysbacteriosis (ID) has been implicated in immune response to respiratory infections. We aimed to investigate the effect of ID on a mouse model of AAD, and the potential molecular factors involved. Ovalbumin (OVA) was employed to sensitize and challenge mice to elicit allergic inflammation in the upper as well as the lower airways. OVA-induced AAD model mice and control mice were raised with or without antibiotics treatment to establish the combinational AAD + ID mouse model...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29699637/risk-factors-for-nasal-bleeding-in-patients-undergoing-transnasal-gastrointestinal-endoscopy
#12
Mitsuyo Mieda, Hiroshi Miyashita, Hiroyuki Osawa, Tomosuke Hirasawa, Nobuko Makino, Sachiko Toma, Takeshi Tomiyama, Yoshimasa Miura, Alan K Lefor, Hironori Yamamoto
Transnasal endoscopy is widely used in screening for upper gastrointestinal lesions because of less associated pain. Nasal bleeding is the most severe adverse effect, but specific risk factors have not been identified. The aim of this study is to identify risk factors for nasal bleeding during transnasal endoscopy. Nasal bleeding occurred in 160/3035 (5.3%) of patients undergoing transnasal endoscopy as part of health checkups. Patient data were retrospectively evaluated including anthropometric, medical, and life-style parameters with multiple logistic regression analysis...
May 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29689043/-treatment-of-allergic-and-vasomotor-rhinitis-the-role-of-beclomethasone-dipropionate-and-hyaluronic-acid-with-high-molecular-weight
#13
Giorgio Ciprandi, Matteo Gelardi
Inflammatory rhinitis is a very common disorder. It includes allergic rhinitis (AR) and non-allergic rhinitis (NAR). Nasal inflammation is shared by both disorders. So, anti-inflammatory treatment is indicated for both. Beclomethasone dipropionate (BDP) is a corticosteroid that is long time available both as intranasal spray and aerosol solution. BDP is a corticosteroid with proved efficacy in the treatment of rhinitis, both as spray and aerosol. Safety issue has been satisfactory explored, thus BDP is usually safe and well tolerated...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29682983/long-term-clinical-outcomes-of-aspirin-desensitization-with-continuous-daily-aspirin-therapy-in-aspirin-exacerbated-respiratory-disease
#14
Kristen M Walters, Jeremy D Waldram, Katharine M Woessner, Andrew A White
Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis. ASA desensitization with daily ASA therapy is a uniquely beneficial treatment for this disease entity and has been shown to have a significant impact on symptom scores, polyp disease, and need for systemic corticosteroids. However, no long-term studies have demonstrated whether or not ASA therapy remains safe and beneficial for these patients beyond 5-10 years...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29678748/severity-of-allergic-rhinitis-assessed-by-urine-metabolomic-profiling-proof-of-concept
#15
Darryl J Adamko, Mona M Khamis, Lisa M Steacy, Shana Regush, Rhonda Bryce, Anne K Ellis
Patients with chronic airway diseases tend to become "accustomed" to their impairments and fail to recognize the significance of their symptoms. We suggest that a metabolomic approach could become a diagnostic/monitoring solution in clinical trials or in a typical doctor's office.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678484/chronic-respiratory-rhinitis
#16
R Jankowski, P Gallet, D T Nguyen, C Rumeau
The clinical distinction of chronic respiratory rhinitis appears to confirm the evo-devo theory of the three noses. The authors report two cases of advanced allergic rhinitis, in which chronic inflammation had induced a violaceous colour of the mucosa of the respiratory nose and a whitish polypoid appearance of the free edge of the middle turbinate. Nose and paranasal sinus CT scan revealed, beyond the virtual nasal cavities observed on nasal endoscopy and CT imaging, normal radiolucency or only minor opacities of the ethmoid (i...
April 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29676177/acetylcholine-induced-ciliary-beat-of-the-human-nasal-mucosa-is-regulated-by-the-pannexin-1-channel-and-purinergic-p2x-receptor
#17
Ba H Do, Toyoaki Ohbuchi, Tetsuro Wakasugi, Hiroki Koizumi, Mitsuru Yokoyama, Nobusuke Hohchi, Hideaki Suzuki
Background Airway mucociliary transport is an important function for the clearance of inhaled foreign particulates in the respiratory tract. The present study aimed at investigating the regulatory mechanism of acetylcholine (Ach)-induced ciliary beat of the human nasal mucosa in ex vivo. Methods The inferior turbinate mucosa was collected from patients with chronic hypertrophic rhinitis during endoscopic surgery. The mucosa was cut into thin strips, and ciliary movement was observed under a phase-contrast light microscope with a high-speed digital video camera...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29663342/associations-of-chronic-urticaria-with-atopic-and-autoimmune-comorbidities-a-nationwide-population-based-study
#18
Hsien-Yi Chiu, Chih-Hsin Muo, Fung-Chang Sung
BACKGROUND: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. OBJECTIVES: This study aims to examine the association between CU, and atopic and autoimmune diseases. METHODS: This population-based retrospective cohort study identified 9,332 patients with CU and 37,328 controls matched for age, sex, and number of dermatological clinic visits from the Taiwan National Health Insurance Research Database for 2004-2009...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662303/the-effectiveness-of-long-term-course-of-sterimar-mn-nasal-spray-for-treatment-of-the-recurrence-rates-of-acute-allergic-rhinitis-in-patients-with-chronic-allergic-rhinitis
#19
Michele Grasso, Marco de Vincentiis, Griselda Agolli, Francesco Cilurzo, Raffaele Grasso
Background: The "cost of illness" of the acute allergic rhinitis (AR) episodes in patients with chronic AR is very high in terms of therapy and quality of life. AR represents a worldwide health problem; despite the fact that many standardized treatments have been proposed and used, the recurrence rate of acute rhinitis episodes in springtime is always higher. Materials and methods: Sixty consecutive patients (13 F and 17 M in group A, 15 F and 15 M in group B; p =0...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29661611/nasal-polyposis-or-chronic-olfactory-rhinitis
#20
R Jankowski, C Rumeau, P Gallet, D T Nguyen
The concept of chronic rhinosinusitis with or without polyps is founded on the structural and functional unicity of the pituitary mucosa and its united response to environmental aggression by allergens, viruses, bacteria, pollution, etc. The present review sets this concept against the evo-devo three-nose theory, in which nasal polyposis is distinguished as specific to the olfactory nose and in particular to the non-olfactory mucosa of the ethmoid, which is considered to be not a sinus but rather the skull-base bone harboring the olfactory mucosa...
April 13, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
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