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https://www.readbyqxmd.com/read/29618409/-acute-severe-colitis
#1
Sophie Ribiere, Mahaut Leconte, Stanislas Chaussade, Vered Abitbol
Acute severe colitis is a potentially life-threatening medical and surgical emergency requiring hospitalization and intensive monitoring. The diagnosis of severe acute colitis is based on clinical and biological criteria. Colectomy should be discussed at each stage of management and is indicated immediately in case of complications. Thromboembolic prevention with low molecular weight heparin is essential in any patient with severe acute colitis. The first-line medical treatment is intravenous corticosteroid at a dose of 0...
April 1, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29609685/stability-of-regularly-prescribed-oral-liquids-formulated-with-syrspend-%C3%A2-sf
#2
M Uriel, C Gómez-Rincón, D Marro
The purpose of this research was to evaluate the stability of 12 oral liquid formulations frequently compounded in hospital and community settings formulated in a specific vehicle: SyrSpend® SF. The stability of melatonin, glycopyrrolate, ciclosporin, chloral hydrate, flecainide acetate, tiagabine HCl, labetalol HCl, ciprofloxacin HCl, spironolactone/hydrochlorothiazide, hydrocortisone, itraconazole and celecoxib in SyrSpend SF PH4 (liquid) was investigated at 0, 30, 60 and 90 days and stored at both controlled room temperature and refrigerated...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#3
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29545413/efficacy-and-safety-of-0-1-ciclosporin-a-cationic-emulsion-in-dry-eye-disease-a-pooled-analysis-of-two-double-masked-randomised-vehicle-controlled-phase-iii-clinical-studies
#4
Andrea Leonardi, Elisabeth M Messmer, Marc Labetoulle, Mourad Amrane, Jean-Sébastien Garrigue, Dahlia Ismail, Maite Sainz-de-la-Maza, Francisco C Figueiredo, Christophe Baudouin
BACKGROUND/AIM: To assess the treatment effect of 0.1%ciclosporin A cationic emulsion (CsA CE) versus vehicle on signs/symptoms of dry eye disease (DED) in various subgroups (moderate-to-severe DED/severe DED/Sjögren's syndrome (SS)/SS with severe DED). METHODS: Pooled data were analysed from two similar phase III studies: SICCANOVE (moderate-to-severe DED) and SANSIKA (severe DED with severe keratitis). In both studies, patients aged ≥18 years received CsA CE 0...
March 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29506124/clinical-response-and-complications-are-not-associated-with-drug-levels-in-patients-with-severe-ulcerative-colitis-on-iv-cyclosporine-induction-therapy
#5
Parita Patel, Andres Yarur, Sushila Dalal, Atsuhi Sakuraba, David T Rubin, Stephen B Hanauer, Ira Hanan, Laura H Raffals, Russell D Cohen, Joel Pekow
Background: IV ciclosporin therapy is effective in steroid-refractory ulcerative colitis. The optimal drug level to achieve response and minimize complications during induction therapy is not known. Aim: The primary aim was to evaluate if serum ciclosporin drug levels are associated with increased risk of colectomy within 90 days of hospitalization. Secondary aims were to determine if ciclosporin levels are associated with avoidance of colectomy at 7 and 30 days, if ciclosporin levels are associated with drug-related and postoperative complications, and if patient-specific factors are associated with response to ciclosporin...
March 1, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29478396/ciclosporin-and-the-cat-current-understanding-and-review-of-clinical-use
#6
Silvia Colombo, Roberta Sartori
Practical relevance: Ciclosporin (CsA) is a systemic immuno-modulatory drug widely used to treat immune-mediated diseases in humans and veterinary species. CsA was registered for use in cats in the USA and Europe in 2011, and is indicated for the treatment of chronic allergic dermatitis at a recommended daily dose of 7 mg/kg PO. AUDIENCE: This review will be of interest to all veterinarians working with cats, given the wide range of potential applications of CsA and its safety profile...
March 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29477277/two-year-management-after-renal-transplantation-in-2013-in-france-input-from-the-french-national-health-system-database
#7
Philippe Tuppin, Antoine Bessou, Camille Legeai, Cécile Vigneau, Cécile Couchoud
The objective of this study was to describe the management of patients undergoing renal transplantation in 2013 and over the following two years on the basis of healthcare consumption data. The National Health Insurance Information System was used to identify 1876 general scheme beneficiaries undergoing a first isolated renal transplantation (median age: 53 years; men 63%). Overall, 1.2% of patients died during the transplantation hospital stay (>65 years 3.3%) and 87% of patients had a functional graft at 2 years...
February 21, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29475513/single-blinded-randomized-placebo-controlled-study-on-the-effects-of-ciclosporin-on-cutaneous-barrier-function-and-immunological-response-in-atopic-beagles
#8
Amelia G White, Domenico Santoro, Kim Ahrens, Rosanna Marsella
Ciclosporin (CsA) is a common treatment for canine atopic dermatitis (cAD). cAD is a very common skin disease with a multifactorial pathogenesis due to complex interactions between the host and the environment. The purpose of this study was to describe the physical and immunological effects of CsA in cAD using a canine model of AD. Fourteen beagles were enrolled; seven received CsA orally every 24 h for 28 days, and seven received placebo. All dogs were exposed to relevant allergens, house dust mite solution, one day prior to treatment and once weekly thereafter for 28 consecutive days...
March 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29471815/glucocorticosteroids-and-ciclosporin-do-not-significantly-impact-canine-cutaneous-microbiota
#9
Giovanni Widmer, Lluís Ferrer, Claude Favrot, Judy Paps, Kevin Huynh, Thierry Olivry
BACKGROUND: As prednisone and ciclosporin can have immunosuppressive effects and have been considered potential predisposing factors for skin infections, we investigated the impact of these drugs on the diversity of the cutaneous microbiota, the abundance of Malassezia and infection with Papillomaviruses. RESULTS: Six atopic, asymptomatic Maltese-beagle dogs were treated with ciclosporin for one month and then with prednisone for another month, with a one-month wash-out between treatments...
February 23, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29463376/ciclosporin-a-as-a-reversal-agent-against-concurrent-multidrug-resistance-in-tumors-with-nanobubbles
#10
Shuang Ding, Nishant Patel, Haijun Zhang
The purpose of this work was to challenge the multidrug resistance (MDR) in tumor through nanobubbles (NB) co-loaded reversal agent and chemotherapeutic drug layer by layer. The core/shell NB structure contains Doxorubicin (Dox) as anticancer drug in the core and Ciclosporin A (CsA), a cyclic polypeptide composed of 11 amino acids, as a reversal agent in the shell. The drug was designed to work against concurrent MDR processes and was defined as CsA/Dox/NB. HL60/ADM cells with typical high expression of multidrug resistance associated protein 1 (MRP1) were assessed by flow cytometer, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, and Western blot analysis to observe the in vitro and in vivo anticancer efficacy and reversal ability of MDR...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29449025/-prospective-monocentric-uncontrolled-study-of-efficacy-tolerance-and-adherence-of-cyclosporin-0-1-for-severe-dry-eye-syndrome
#11
Y Boujnah, R Mouchel, H El-Chehab, C Dot, C Burillon, V Kocaba
PURPOSE: To evaluate the efficacy, tolerability and treatment adherence of Ikervis ® (Santen, SAS) (ciclosporine 0.1 %) for first line therapy or following treatment with Restasis ® (Allergan, Inc.) (ciclosporine 0.05 %) for severe dry eye syndrome. MATERIAL AND METHODS: A prospective, monocentric, uncontrolled study was conducted between January 2012 and March 2015 on 110 eyes of 55 patients with severe dry eye on first line therapy or previously treated with Restasis ® who required the introduction of Ikervis ® ...
February 12, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29437743/minimal-change-disease-with-maximum-immunosuppression-successful-treatment-of-steroid-dependent-minimal-change-disease-with-rituximab
#12
Helena Pinto, Nuno Oliveira, Fátima Costa, Rui Alves
Minimal change disease (MCD) is usually steroid sensitive, although in case of steroid dependent and multiple relapses we can struggle with different immunosuppressive agents, sometimes with no response. Rituximab has been emerging as an alternative therapeutic option.We describe a case of a young patient with MCD that had frequent relapses and steroid dependency, with no response to several immunosuppressive agents during 15 years of disease. He was kept under high-dose steroids and ciclosporin. He started treatment with rituximab (two administrations of 1 g 2 weeks apart, repeating after 6 months)...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29433635/-current-and-upcoming-treatments-of-adult-atopic-dermatitis
#13
J-P Lacour
The treatment of atopic dermatitis in adults is based on the use of topical steroids and emollients. When AD is resistant to a well-conducted topical treatment, phototherapy or systemic treatments can be used: ciclosporin, methotrexate, azathioprine or mycophenolate mofetil. The therapeutic landscape of adult AD is about to change and even be revolutionized by the imminent arrival of new treatments: topical phosphodiesterase 4 inhibitors, topical or systemic JAK inhibitors, anti-IL-4 and/or antiIL-13 biotherapies (dupilumab, tralokinumab, lebrikizumab), anti-IL-31 (nemolizumab), anti-TSLP...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29423002/ndufa4-enhances-neuron-growth-by-triggering-growth-factors-and-inhibiting-neuron-apoptosis-through-bcl-2-and-cytochrome-c-mediated-signaling-pathway
#14
Fang Fu, Yan Li, Ru Li, Ting-Ying Lei, Dan Wang, Xin Yang, Jin Han, Min Pan, Li Zhen, Yan-Mei Ou, Jian Li, Fao-Tao Li, Xiang-Yi Jing, Dong-Zhi Li, Can Liao
Dandy-Walker malformation (DWM) is the most prevalent congenital malformation in cerebellum, however, pathological mechanism of DWM has not been fully clarified. This study aims to investigate effects of NDUFA4 on growth of neurons. LV5-NDUFA4 and LV3-NDUFA4-RNAi lentivirus were constructed and transfected to neurons. Ciclosporin A, together with the two lentivirus were applied to neurons to observe neuron growth, apoptosis, and related protein expression. MTT assay was used to observe neuron growth. Apoptosis was detected by using flow cytometry assay...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29377194/effect-of-ultraviolet-irradiation-on-free-radical-scavenging-activity-of-immunosuppressants-used-in-lung-transplantation-and-comparative-electron-paramagnetic-resonance-study-of-kinetics-of-their-interactions-with-model-free-radicals
#15
A Stanjek-Cichoracka, S Żegleń, P Ramos, B Pilawa, J Wojarski
WHAT IS KNOWN AND OBJECTIVE: The immunosuppressive drugs used in solid organ transplantation or autoimmunological processes were studied by electron paramagnetic resonance (EPR) spectroscopy to estimate their free radical scavenging activity. The interactions of immunosuppressants with free radicals were examined by an X-band (9.3 GHz) EPR spectroscopy and a model of DPPH free radicals. METHODS: The EPR spectra of DPPH and DPPH interacting with individual drugs were compared...
January 27, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29369774/ciclosporin-for-epidermal-necrolysis-absence-of-beneficial-effect-in-a-retrospective-cohort-of-174-patients-exposed-unexposed-and-propensity-score-matched-analyses
#16
F Poizeau, O Gaudin, L Le Cleach, T A Duong, C Hua, C Hotz, S Ingen-Housz-Oro, E Sbidian, O Zehou, A Colin, N de Prost, B Lebrun-Vignes, O Chosidow, P Wolkenstein, L Fardet
Ciclosporin has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with SJS/TEN during 2005-2016. Among them, 95 received ciclosporin (3 mg/kg/day) plus supportive care and 79 supportive care only. Both a traditional exposed/unexposed method and a propensity-score matching method were used to compare the progression of skin detachment between day 0 and day 5, the proportion of patients with cutaneous re-epithelialization starting on day 5 or mucosal re-epithelialization on day 10, the duration of progression, and the number of deaths between the two groups...
January 21, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29359341/systematic-review-with-meta-analysis-de-novo-non-alcoholic-fatty-liver-disease-in-liver-transplanted-patients
#17
REVIEW
G Losurdo, A Castellaneta, M Rendina, S Carparelli, G Leandro, A Di Leo
BACKGROUND: De novo non-alcoholic fatty liver disease (NAFLD) in liver-transplanted patients for cirrhosis not due to non-alcoholic steatohepatitis (NASH) is becoming a growing phenomenon. AIMS: We performed a systematic review and evaluated the prevalence of this event and possible associated factors. METHODS: A literature search in medical databases (PubMed, MEDLINE/OVIDSP, Science Direct and EMBASE) was performed in March 2017. Relevant publications were identified in most important databases...
March 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29357999/recommendations-of-the-spanish-working-group-on-crohn-s-disease-and-ulcerative-colitis-geteccu-on-the-use-of-tiopurines-in-inflammatory-bowel-disease
#18
Fernando Bermejo, Mariam Aguas, María Chaparro, Eugeni Domènech, Ana Echarri, Esther García-Planella, Iván Guerra, Javier P Gisbert, Antonio López-Sanromán
Thiopurines (azathioprine and mercaptopurine) are widely used in patients with inflammatory bowel disease. In this paper, we review the main indications for their use, as well as practical aspects on efficacy, safety and method of administration. They are mainly used to maintain remission in steroid-dependent disease or with ciclosporin to control a severe ulcerative colitis flare-up, as well as to prevent postoperative Crohn's disease recurrence, and also in combination therapy with biologics. About 30-40% of patients will not respond to treatment and 10-20% will not tolerate it due to adverse effects...
March 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29328012/-a-man-with-severe-skin-rash
#19
T V Nguyen, G L van Rooijen, M B A van Doorn
A 31-year-old man visited the outpatient clinic Dermatology with an exacerbation of his atopic eczema. Since a few day vesicles and crusts had appeared and his eyelids were swollen. He was known to have eczema, for which he was treated with ciclosporin 200 mg 2 times a day (4 mg/kg per day) since four months. Under this treatment the eczema used to be under control. There were no neurological symptoms or vision problems. At physical examination we saw erythematous papules, vesicles, superficial erosions and crusts on all body regions, but especially on the trunk and in the main neck region...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29303047/eltrombopag-in-the-management-of-aplastic-anaemia-real-world-experience-in-a-non-trial-setting
#20
Yu-Yan Hwang, Harinder Gill, Thomas S Y Chan, Garret M K Leung, Carol Y M Cheung, Yok-Lam Kwong
OBJECTIVE: The thrombopoietin mimetic eltrombopag has been used in clinical trials for the frontline and salvage treatment of aplastic anaemia (AA). Eltrombopag was investigated in AA patients on a non-trial all-comer basis. METHODS: Consecutive newly diagnosed and relapsed/refractory AA patients were treated with eltrombopag. RESULTS: In a 4.5-year period, 20 consecutive AA patients (newly diagnosed, N = 10; relapsed/refractory, N = 10) at a median age of 47 (22-84) years were treated with eltrombopag...
January 5, 2018: Hematology (Amsterdam, Netherlands)
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