keyword
MENU ▼
Read by QxMD icon Read
search

cyclosporin

keyword
https://www.readbyqxmd.com/read/29051147/organic-anion-transporting-polypeptides-oatps-mediated-drug-drug-interaction-study-between-rosuvastatin-and-cyclosporine-a-in-chimeric-mice-with-humanized-liver
#1
Masashi Uchida, Yoriko Tajima, Masakazu Kakuni, Yutaka Kageyama, Taro Okada, Eri Sakudara, Chise Tateno, Ryoji Hayashi
The influence of transporters on the pharmacokinetics of drugs is being increasingly recognized, and DDIs via transporters may be a risk factor for adverse events. Cyclosporine A, a strong OATP-inhibitor, has been reported to increase the systemic exposure of rosuvastatin, an OATP-substrate, by 7.1-fold in clinical studies. PXB-mice are chimeric mice with humanized livers that are highly repopulated with human hepatocytes, and have been widely used for drug discovery in DMPK studies. In the present study, we examined in vivo and in vitro DDIs between rosuvastatin and cyclosporine A in PXB-mice and fresh human hepatocytes (PXB-cells) obtained from PXB-mice...
October 19, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29049193/efficacy-and-safety-of-immunomodulatory-drugs-in-patients-with-anterior-uveitis-a-systematic-literature-review
#2
Alejandro Gómez-Gómez, Estíbaliz Loza, Maria Piedad Rosario, Gerard Espinosa, José M García Ruiz de Morales, Jose M Herreras, Santiago Muñoz-Fernández, Miguel Cordero-Coma
BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complementary hand search was also performed. The selection criteria were as follows: (population) noninfectious AU patients, adults; (intervention) immunomodulatory drugs (any dose, regimen, route of administration, duration of treatment); (outcome) control of inflammation, steroid-sparing effect, AU flares, adverse events, and so on; (study design) systematic literature reviews, randomized controlled trials, and observational studies...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049039/serum-cyclosporine-levels-the-influence-of-the-time-interval-between-interrupting-the-infusion-and-obtaining-the-samples-a-randomized-clinical-trial
#3
Livia Maria Garbin, Belinda Pinto Simões, Ana Carolina de Jesus Vieira Curcioli, Emilia Campos de Carvalho
BACKGROUND: There are controversies regarding the best way to collect blood samples for cyclosporine A (CsA) serum levels when this immunosuppressant is administered continuously through a silicone central venous catheter (CVC) to hematopoietic stem cell transplant recipients. OBJECTIVE: The aim of this study was to verify the effect of the time elapsed between the interruption of a continuous intravenous CsA infusion and the collection of blood samples on CsA serum levels...
October 18, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/29047148/epidemiological-survey-of-patients-with-psoriasis-in-matsumoto-city-nagano-prefecture-japan
#4
Eisaku Ogawa, Ryuhei Okuyama, Tomoko Seki, Aya Kobayashi, Naoki Oiso, Masahiko Muto, Hidemi Nakagawa, Akira Kawada
A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84...
October 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29045704/new-onset-diabetes-after-kidney-transplantation-can-the-risk-be-modified-by-choosing-immunosuppression-regimen-based-on-pretransplant-viral-serology
#5
Alfonso H Santos, Chao Chen, Michael J Casey, Karl L Womer, Xuerong Wen
Background: This study aimed to analyze adult kidney transplant recipients (KTRs) for the risk of new-onset diabetes after transplantation (NODAT) associated with viral serologies and immunosuppression regimens [tacrolimus (Tac) + mycophenolate (MPA), cyclosporine (CSA) + MPA, sirolimus (SRL) + MPA, SRL + CSA or SRL +Tac]. Methods: Cox regression models were used to examine the risk of NODAT in the first posttransplant year associated with: (i) CSA + MPA, SRL + MPA, SRL + MPA or SRL + Tac versus reference, Tac + MPA; (ii) pretransplant viral serology [+ or -; hepatitis B core (HBc), hepatitis C (HCV), cytomegalovirus (CMV) or Epstein Barr Virus (EBV)]; and (iii) interactions between immunosuppression regimens and the viral serology found significant in the main analysis...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29044971/drug-nanocrystals-for-cancer-therapy
#6
REVIEW
Xiaoqing Miao, Wuwei Yang, Tao Feng, Jing Lin, Peng Huang
Drug nanocrystals (NCs) with fascinating physicochemical properties have attracted great attention in drug delivery. High drug-loading efficiency, great structural stability, steady dissolution, and long circulation time are a few examples of these properties, which makes drug NCs an excellent formulation for efficient cancer therapy. In the last two decades, there are a lot of hydrophobic or lipophilic drugs, such as paclitaxel (PTX), camptothecin (CPT), thymectacin, busulfan, cyclosporin A, 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH), and so on, which have been formulated into drug NCs for cancer therapy...
October 17, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29044681/does-omalizumab-modify-a-course-of-recalcitrant-chronic-spontaneous-urticaria-a-retrospective-study-in-asian-patients
#7
Kanokvalai Kulthanan, Papapit Tuchinda, Chayanee Likitwattananurak, Puncharas Weerasubpong, Leena Chularojanamontri
Omalizumab has been approved for the treatment of recalcitrant chronic spontaneous urticaria (CSU). However, it remains unanswered whether omalizumab modifies a CSU course. We aimed to study a course of CSU after omalizumab treatment in an Asian population. Medical records of recalcitrant CSU patients who attended Siriraj Hospital between 2013 and 2017 were reviewed. All patients receiving omalizumab treatment were followed after the first injection for at least 1 year. Of 15 patients receiving omalizumab treatment, 11 patients (73...
October 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29044179/the-effect-of-insecticide-synergist-treatment-on-genome-wide-gene-expression-in-a-polyphagous-pest
#8
Simon Snoeck, Robert Greenhalgh, Luc Tirry, Richard M Clark, Thomas Van Leeuwen, Wannes Dermauw
Synergists can counteract metabolic insecticide resistance by inhibiting detoxification enzymes or transporters. They are used in commercial formulations of insecticides, but are also frequently used in the elucidation of resistance mechanisms. However, the effect of synergists on genome-wide transcription in arthropods is poorly understood. In this study we used Illumina RNA-sequencing to investigate genome-wide transcriptional responses in an acaricide resistant strain of the spider mite Tetranychus urticae upon exposure to synergists such as S,S,S-tributyl phosphorotrithioate (DEF), diethyl maleate (DEM), piperonyl butoxide (PBO) and cyclosporin A (CsA)...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043889/unconventional-treatments-for-chronic-inflammatory-demyelinating-polyneuropathy
#9
Yusuf A Rajabally
This article focuses on the unconventional treatments used in chronic inflammatory demyelinating polyneuropathy (CIDP). First line, evidence-based treatments for CIDP include corticosteroids, immunoglobulins and plasma exchanges. Several unproven treatments are however given in treatment-refractory disease or to reduce requirements in validated therapies for reasons of side effects/practical delivery/cost. Despite methodological issues, IFN-α, azathioprine and methotrexate have not been shown to be useful in randomized controlled trials...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29043142/costimulation-pathway-blockade-in-kidney-transplant-recipients-with-de-novo-rheumatoid-arthritis
#10
Mohamed Sheta, Samy Riad, Udayakumar Deepak, Naim Issa, Mark Birkenbach, Hassan N Ibrahim, Aleksandra Kukla
The best approach to treatment of de-novo rheumatoid arthritis in solid organ transplant recipients on typical immunosuppression is not well established. The use of biologics targeting specific cell types, cytokines, and immunological pathways has been gaining interest in the treatment of both, auto- and alloimmunity. We present a case of de-novo rheumatoid arthritis in a kidney transplant recipient 10 years post-transplant while receiving cyclosporine, mycophenolate mofetil, and also prednisone. Initial presentation included features of polymyalgia rheumatica and nephrotic range proteinuria...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29040122/treatment-and-resolution-of-filamentary-keratitis-in-a-patient-with-stiff-person-syndrome
#11
Steven S Bae, Sonia N Yeung, Clara C Chan
PURPOSE: To report a rare case of filamentary keratitis associated with stiff person syndrome. METHODS: Case report. RESULTS: A 26-year-old woman with several autoimmune conditions was referred because of filamentary keratitis. Conservative management using lubrication, mucolytics, and bandage contact lenses failed to adequately relieve symptoms. Despite the addition of oral prednisone, cyclosporine, and azathioprine, the patient's condition persisted with numerous filaments and severe dry eye...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29039273/in-vitro-selection-of-phytomonas-serpens-cells-resistant-to-the-calpain-inhibitor-mdl28170-alterations-in-fitness-and-expression-of-the-major-peptidases-and-efflux-pumps
#12
Simone S C Oliveira, Inês C Gonçalves, Vitor Ennes-Vidal, Angela H C S Lopes, Rubem F S Menna-Barreto, Claudia M D'Ávila-Levy, André L S Santos, Marta H Branquinha
The species Phytomonas serpens is known to express some molecules displaying similarity to those described in trypanosomatids pathogenic to humans, such as peptidases from Trypanosoma cruzi (cruzipain) and Leishmania spp. (gp63). In this work, a population of P. serpens resistant to the calpain inhibitor MDL28170 at 70 µ m (MDLR population) was selected by culturing promastigotes in increasing concentrations of the drug. The only relevant ultrastructural difference between wild-type (WT) and MDLR promastigotes was the presence of microvesicles within the flagellar pocket of the latter...
October 17, 2017: Parasitology
https://www.readbyqxmd.com/read/29037868/the-fungal-neurotoxin-penitrem-a-induces-the-production-of-reactive-oxygen-species-in-human-neutrophils-at-submicromolar-concentrations
#13
H F Berntsen, I L Bogen, M B Wigestrand, F Fonnum, S I Walaas, A Moldes-Anaya
Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the neurotoxin. The aim of this study was to examine the potential of penitrem A to induce ROS production in isolated human neutrophil granulocytes, and to study possible mechanisms involved. Penitrem A significantly increased the production of ROS in human neutrophils at concentrations as low as 0...
October 13, 2017: Toxicology
https://www.readbyqxmd.com/read/29034434/genomic-analyses-reveal-low-mitochondrial-and-high-nuclear-diversity-in-the-cyclosporin-producing-fungus-tolypocladium-inflatum
#14
Yong-Jie Zhang, Xiao-Qing Yang, Shu Zhang, Richard A Humber, Jianping Xu
Mitochondrial DNA is generally regarded to evolve faster than nuclear DNA in animals, whereas if this is also true in fungi remains unclear. Herein, we annotate the first complete mitochondrial genome (mitogenome) of the cyclosporin-producing fungus Tolypocladium inflatum and report the genome-wide sequence variations among five isolates originating from distantly separated localities. We found that T. inflatum has among the most compact of fungal mitogenomes; its 25 kb DNA molecule encodes all standard fungal mitochondrial genes and harbors only one intron...
October 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29033818/itolizumab-a-new-biologic-for-management-of-psoriasis-and-psoriatic-arthritis
#15
Ganesh Pai, Anusha H Pai
Psoriasis is a chronic, relapsing, inflammatory, immune-mediated systemic disease with mainly skin and joint manifestations. The available treatment options to cure psoriasis include topical therapy, phototherapy, and biological therapy. Biological therapy has become a promising option due to the rapid action and less adverse effects associated with its use. The newly developed biologic itolizumab is a humanized recombinant anti-CD6 monoclonal antibody of IgG1 isotype that binds to domain 1 of CD6, thereby immunomodulating human lymphocytes without interfering with the binding of CD6 to the activated leukocyte-cell adhesion molecule...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29031076/synthesis-and-evaluation-of-new-pyridyl-pyrazinyl-thiourea-derivatives-neuroprotection-against-amyloid-%C3%AE-induced-toxicity
#16
Jung-Eun Park, Ahmed Elkamhawy, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Sora Paik, Beoung-Geon Park, Eun Joo Roh
Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen compounds against Aβ-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Fifteen derivatives eliciting increased green to red fluorescence percentage less than 40.0% were evaluated for their impact on ATP production, cell viability and neuroprotection against Aβ-induced neuronal cell death...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030429/activating-mutations-in-quorum-sensing-regulator-rgg2-and-its-conformational-flexibility-in-the-absence-of-an-intermolecular-disulfide-bond
#17
Reid V Wilkening, Glenn C Capodagli, Atul Khataokar, Kaitlyn M Tylor, Matthew B Neiditch, Michael J Federle
Rap/Rgg/NprR/PlcR/PrgX (RRNPP) quorum-sensing systems use extracellular peptide pheromones that are detected by cytoplasmic receptors to regulate gene expression in firmicute bacteria. Rgg-type receptors are allosterically regulated through direct pheromone binding to control transcriptional activity; however, the receptor activation mechanism remains poorly understood. Previous work has identified a disulfide bond between Cys-45 residues within the homodimer interface of Rgg2 from Streptococcus dysgalactiae (Rgg2Sd)...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29029404/quercetin-induced-ros-production-triggers-mitochondrial-cell-death-of-human-embryonic-stem-cells
#18
So-Yeon Kim, Ho-Chang Jeong, Soon-Ki Hong, Mi-Ok Lee, Seung-Ju Cho, Hyuk-Jin Cha
Small molecules to selectively induce cell death of undifferentiated human pluripotent stem cells (hPSCs) have been developed with the aim of lowering the risk of teratoma formation during hPSC-based cell therapy. In this context, we have reported that Quercetin (QC) induces cell death selectively in hESCs via p53 mitochondrial localization. However, the detailed molecular mechanism by which hESCs undergo selective cell death induced by QC remains unclear. Herein, we demonstrate that mitochondrial reactive oxygen species (ROS), strongly induced by QC in human embryonic stem cells (hESCs) but not in human dermal fibroblasts (hDFs), were responsible for QC-mediated hESC's cell death...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#19
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29021093/disseminated-cryptococcosis-in-a-patient-taking-tocilizumab-for-castleman-s-disease
#20
Hiroaki Nishioka, Hiroshi Takegawa, Hiroki Kamei
Infections occur more frequently in patients receiving biologics. However, cryptococcal infection is uncommon in patients receiving tocilizumab, an interleukin-6 inhibitor, in contrast to patients receiving tumor necrosis factor-α inhibitors. In this report, we describe a case of disseminated cryptococcosis in a 55-year-old man who was receiving tocilizumab every 2 weeks along with daily prednisolone and cyclosporine for Castleman's disease. He initially developed cellulitis on both upper limbs, and his condition worsened despite antibacterial therapy...
October 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
keyword
keyword
33150
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"