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https://www.readbyqxmd.com/read/29449025/-prospective-monocentric-uncontrolled-study-of-efficacy-tolerance-and-adherence-of-cyclosporin-0-1-for-severe-dry-eye-syndrome
#1
Y Boujnah, R Mouchel, H El-Chehab, C Dot, C Burillon, V Kocaba
PURPOSE: To evaluate the efficacy, tolerability and treatment adherence of Ikervis ® (Santen, SAS) (ciclosporine 0.1 %) for first line therapy or following treatment with Restasis ® (Allergan, Inc.) (ciclosporine 0.05 %) for severe dry eye syndrome. MATERIAL AND METHODS: A prospective, monocentric, uncontrolled study was conducted between January 2012 and March 2015 on 110 eyes of 55 patients with severe dry eye on first line therapy or previously treated with Restasis ® who required the introduction of Ikervis ® ...
February 12, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29448882/multitarget-therapy-of-mycophenolate-mofetil-and-cyclosporine-a-for-induction-treatment-of-refractory-lupus-nephritis
#2
D Jesus, M Rodrigues, J A P da Silva, L Inês
Standard induction therapy for lupus nephritis (LN) with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) is often ineffective. Evidence on rescue induction regimens is scarce. We analyzed efficacy and tolerability of multitarget immunosuppression with MMF and cyclosporine A (CsA) as induction treatment for LN (class III/IV/V) refractory to CYC and/or MMF. We included all six refractory LN patients (class IV = 3, class V = 2, class III = 1) from our 400-patient tertiary Lupus Clinic observed between 2012 and 2015...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29447638/pediatric-pustular-psoriasis-responsive-to-cyclosporine-bridged-to-etanercept-a-treatment-approach
#3
Corey Georgesen, Horatio Wildman, Xuan Wang, Cynthia Magro
Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Using this case example, we highlight the three most important considerations in any patient with new onset pustularpsoriasis: avoidance of disease complications, acute "rescue" therapy, and maintenance therapy...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29446857/infectious-risk-of-biological-drugs-versus-traditional-systemic-treatments-in-moderate-to-severe-psoriasis-a-cohort-analysis-in-the-french-insurance-database
#4
Sylvain Couderc, Maryse Lapeyre-Mestre, Robert Bourrel, Paul Carle, Jean-Louis Montastruc, Agnès Sommet
The aim of this study was to compare the infectious risk between a group of psoriasis patients treated by Biological Drugs (BD) and a group treated by Traditional Systemic Treatments (TST). We built a retrospective observational cohort study from the French health insurance database in the Midi-Pyrénées area (2.9 million inhabitants, South West of France) using data from 01/01/2010 to 12/31/2013. We compared the infectious risk between 'exposed' patients treated with BD (adalimumab, etanercept, infliximab or ustekinumab) and 'unexposed' patients treated by TST (phototherapy, acitretin, methotrexate or cyclosporine)...
February 15, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29444359/drug-survival-and-post-drug-survival-of-first-line-immunosuppressive-treatments-for-atopic-dermatitis-comparison-between-methotrexate-and-cyclosporine
#5
Sarah Law Ping Man, Guillaume Bouzillé, Nathalie Beneton, Gilles Safa, Alain Dupuy, Catherine Droitcourt
INTRODUCTION: Cyclosporine and methotrexate are the two preferred first-line immunosuppressive treatments in atopic dermatitis. The aim of this study was to compare the treatment profiles of methotrexate and cyclosporine in daily practice as the first-line immunosuppressive treatment in atopic dermatitis, using two survival analyses, "drug survival" (time on the drug) and "post-drug survival" (time between two drugs). METHODS: Retrospective study including patients with moderate-to-severe atopic dermatitis treated with methotrexate or cyclosporine as the first-line immunosuppressive treatment...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29441881/cyclodextrin-complexes-of-a-globular-protein-and-a-lipophilic-oligopeptide-the-effect-of-structure-and-physicochemical-properties
#6
S Jóhannsdóttir, P Saokham, A Magnúsdóttir, T Loftsson
Cyclosporine A (CyA) is a lipophilic oligopeptide that has a very limited solubility in water of only 0.008 mg/ml at ambient temperature. It has the ability to form inclusion complexes with cyclodextrin (CD) whose complexes can self-assemble to form aggregates. We have previously developed eye drops with CyA/CD aggregates. Our aim was to study cyclodextrin complexes of lysozyme, a small polar globular protein, and to compare the results with those obtained for CyA. We also wanted to test the stabilizing effect of CDs on lysozyme...
October 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441742/the-effect-of-mycophenolate-mofetil-versus-cyclosporine-as-combination-therapy-with-low-dose-corticosteroids-in-high-risk-patients-with-idiopathic-membranous-nephropathy-a-multicenter-randomized-trial
#7
Ji Young Choi, Dong Ki Kim, Yang Wook Kim, Tae Hyun Yoo, Jung Pyo Lee, Hyun Chul Chung, Kyu Hyang Cho, Won Suk An, Duk Hyun Lee, Hee Yeon Jung, Jang Hee Cho, Chan Duck Kim, Yong Lim Kim, Sun Hee Park
BACKGROUND: Appropriate immunosuppressive therapy for patients with idiopathic membranous nephropathy (MN) remains controversial. The effect of mycophenolate mofetil (MMF) versus cyclosporine (CsA) combined with low-dose corticosteroids was evaluated in patients with idiopathic MN in a multi-center randomized trial (www.ClinicalTrials.gov NCT01282073). METHODS: A total of 39 biopsy-proven idiopathic MN patients with severe proteinuria were randomly assigned to receive MMF combined with low-dose corticosteroids (MMF group) versus CsA combined with low-dose corticosteroids (CsA group), respectively, and followed up for 48 weeks...
February 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29440872/topical-ocular-0-1-cyclosporine-a-cationic-emulsion-in-dry-eye-disease-patients-with-severe-keratitis-experience-through-the-french-early-access-program
#8
Pierre-Jean Pisella, Marc Labetoulle, Serge Doan, Beatrice Cochener-Lamard, Mourad Amrane, Dahlia Ismail, Catherine Creuzot-Garcher, Christophe Baudouin
Purpose: The objective of this study was to report the evaluation of efficacy and safety of cyclosporine A cationic emulsion (CsA CE) 0.1% for the treatment of severe keratitis in adults with dry eye disease (DED) in a French early-access program. Methods: Patients with DED and severe keratitis (corneal fluorescein staining [CFS] score of 3-5 on the Oxford scale and/or the presence of corneal lesions [filaments or ulcers]) were enrolled in a compassionate use program (Authorization for Temporary Use [ATU]) for once-daily CsA CE, which was approved by French health authorities prior to its registration...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29438756/rapid-improvement-of-prurigo-nodularis-with-cyclosporine-treatment
#9
Lauren E Wiznia, Shields W Callahan, David E Cohen, Seth J Orlow
No abstract text is available yet for this article.
February 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29436671/protective-effect-of-curcumin-against-cyclosporine-a%C3%A2-induced-rat-nephrotoxicity
#10
Jianjun Huang, Xuping Yao, Guobin Weng, Honggang Qi, Xiaolei Ye
This study explored the potential value of curcumin, a natural product, in the protection of CsA‑induced nephrotoxicity. The aim of the present study was to investigate the effects of curcumin on Cyclosporine A (CsA)‑induced renal oxidative stress and determine the potential underlying molecular mechanisms of the renal protective effects of Cur. HK‑2 human renal cells were co‑treated with CsA and various doses of Cur. Cell survival rate was determined by an MTT assay, total cellular protein was collected and oxidative stress in cell homogenates was evaluated by determining the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px) and catalase (CAT), the levels of malondialdehyde (MDA) and reactive oxygen species (ROS), and total antioxidant capacity...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434791/efficacy-and-safety-of-combined-immunosuppressive-therapy-plus-umbilical-cord-blood-infusion-in-severe-aplastic-anemia-patients-a-cohort-study
#11
Xiu Luo, Huina Lu, Bing Xiu, Hao Wu, Bing Li, Ping Li, Yuhua Chen, Lili Zhou, Wenjun Zhang, Yan Dong, Aibin Liang, Yi Ding
The present study aimed to evaluate the efficacy and safety of combined immunosuppressive therapy (IST) plus umbilical cord blood infusion (UCBI) in severe aplastic anemia (SAA) patients. A total of 68 patients with SAA were enrolled in the current prospective cohort study and divided into the IST (n=35; positive control) and IST+UCBI (n=33; experimental) groups according to the treatment conditions. Patients in the IST group were treated with rabbit antithymocyte globulin (r-ATG) at a dose of 2.5 mg/kg through intravenous infusion once a day for five days...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434184/cyclosporin-a-aggravates-calcification-of-vascular-smooth-muscle-cells-under-high-glucose-conditions-with-a-calcifying-medium
#12
Dae Hee Kim, Keon Cheol Lee, Sang Youb Han
BACKGROUND Vascular calcification (VC) progresses substantially even after kidney transplantation, and is a predictor of morbidity and mortality. However, the effect of cyclosporin A (CsA) on VC has not been reported in diabetic kidney transplant patients. In this study, we evaluated the effect of CsA on the VC of mouse vascular smooth muscle cells (VSMCs) under high glucose (HG). MATERIAL AND METHODS To demonstrate the effect of CsA (1.0 µmol/L) and HG (30 mM) in the induction of the VC of the VSMCs, we determined alkaline phosphatase (ALP) activity, microscopic morphology of calcification, the expressions of the calcification and inflammation-related genes, and the intracellular calcium concentrations in VSMCs...
February 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29433768/ginger-polyphenols-attenuate-cyclosporine-induced-disturbances-in-kidney-function-potential-application-in-adjuvant-transplant-therapy
#13
Isiaka Ayofe Adekunle, Christian Eseigbe Imafidon, Ayowole Abraham Oladele, Abiodun Oladele Ayoka
Cyclosporine (CYA), a common immuno-suppressant drug that is used in organ transplants, is associated with nephrotoxic effects. Scientific exploration of natural products of plant origin should be considered; especially, in a world with increasing prevalence of kidney diseases. Effects of ginger polyphenols (GP) in Wistar rats with CYA-induced perturbations in electrolyte balance and kidney function was determined. Fifty Wistar rats were recruited for this study such that graded doses of GP were administered following CYA-induced kidney injury and comparisons were made against control and toxic groups at p < 0...
February 7, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29433307/role-of-hepatic-organic-anion-transporter-2-in-the-pharmacokinetics-of-r-and-s-warfarin-in-vitro-studies-and-mechanistic-evaluation
#14
Yi-An Bi, Jian Lin, Sumathy Mathialagan, Laurie Tylaska, Ernesto Callegari, A David Rodrigues, Manthena V S Varma
Inter-individual variability in warfarin dose requirement demands personalized medicine approaches to balance its therapeutic benefits (anticoagulation) and bleeding risk. Cytochrome P450 2C9 (CYP2C9) genotype-guided warfarin dosing is recommended in the clinic, given the more potent S-warfarin is primarily metabolized by CYP2C9. However, only about 20-30% of inter-patient variability in S-warfarin clearance is associated with CYP2C9 genotype. We evaluated the role of hepatic uptake in the clearance of R- and S-warfarin...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29432892/local-dermal-delivery-of-cyclosporin-a-a-hydrophobic-and-high-molecular-weight-drug-using-dissolving-microneedles
#15
Hye-Rin Jeong, Ji-Yeon Kim, Sang-Nyun Kim, Jung-Hwan Park
Dissolving microneedles (MN) containing cyclosporin A (CyA) were prepared for local delivery of CyA into the dermal layer. The efficacy of using MN to deliver CyA, an insoluble and high molecular weight drug, was observed and compared with oral administration of solubilized CyA. Microneedles containing CyA (CyA MN) were prepared using a closed, low-temperature molding process. The mechanical properties of CyA MN and phase separation were studied regarding the content of CyA. CyA MN were inserted into porcine skin for a predetermined time, and the dissolution and delivered amount of CyA were measured in vitro with an optical microscope and high-performance liquid chromatography (HPLC) analysis of the extracted CyA...
February 9, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29429512/effect-of-human-umbilical-cord-blood-derived-cd34-hematopoietic-stem-cell-on-the-expression-of-wnt4-and-p53-genes-in-a-rat-model-of-hepatocellular-carcinoma
#16
Rania Naiem Sherif, Hussein Abdellatif, Noha Hazem, Neven A Ebrahim, Dalia Saleh, Gamal Shiha, Huda Eltahry, Kamal G Botros, Omar M Gabr
BACKGROUND AND AIM OF THE WORK: Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy. Chronic liver injuries as chronic hepatitis C and hepatitis B viruses, aflatoxins consumption and nonalcoholic fatty liver disease are well-established causes of HCC. HCC is associated with a series of molecular changes, as alternation in glypican-3, P53 expression and Wnt/β-catenin pathway. Hepatic cancer progenitor cells could contribute to HCC development. This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathological grading and hepatic progenitor cells percentage in HCC rat model...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29427738/reversal-of-drug-induced-gingival-overgrowth-by-uv-mediated-apoptosis-of-gingival-fibroblasts-an-in-vitro-study
#17
Casey Ritchhart, Anita Joy
Gingival Overgrowth (GO) is an undesirable result of certain drugs like Cyclosporine A (CsA). Histopathology of GO shows hyperplasia of gingival epithelium, expansion of connective tissue with increased collagen, or a combination. Factors such as age, gender, oral hygiene, duration, and dosage also influence onset and severity of GO. One of the mechanisms behind uncontrolled cell proliferation in drug-induced GO is inhibition of apoptotic pathways, with a consequent effect on normal cell turnover. Our objective was to determine if UV photo-treatment would activate apoptosis in the gingival fibroblast component...
February 7, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29427400/pharmacokinetic-interaction-between-faldaprevir-and-cyclosporine-or-tacrolimus-in-healthy-subjects-a-prospective-open-label-fixed-sequence-cross-over-study
#18
Fenglei Huang, Claudia Voelk, Matthias Trampisch, Lois Rowland, Armin Schultz, John P Sabo
Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus. In this single-centre, open-label, fixed-sequence, cross-over study of 32 healthy adult male and female volunteers, subjects received either a single dose of cyclosporine (CsA) 50 mg (N=16) or tacrolimus (TAC) 0.5 mg (N=16), followed by a washout of at least 14 days. Each subject then received a loading dose of FDV 240 mg followed by 120 mg FDV once daily for 6 days. FDV 120 mg was then co-administered with an additional single dose of CsA (50 mg) or TAC (0...
February 10, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29426003/programmed-necrosis-in-heart-disease-molecular-mechanisms-and-clinical-implications
#19
Hong Zhu, Aijun Sun
Programmed cell death plays an essential role in myocardial homeostasis and pathology. Three distinct forms of programmed cell death have been identified, namely apoptosis, necrosis, and autophagic cell death. Necrosis, previously known as an unregulated form of cell death, has been recognized as a highly regulated process now and attracted great attention over the past decade. Programmed necrosis mainly refers to necroptosis, pyroptosis, ferroptosis, and mitochondrial permeability transition (MPT)-dependent necrosis...
February 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29425521/identifiable-risk-factors-and-miscalculations-during-listing-for-pediatric-heart-transplantation
#20
REVIEW
Hugo R Martinez, Samuel Wittekind, Roosevelt Bryant, James S Tweddell, Clifford Chin
The objective of this study is to describe identifiable risk factors, complications, and pitfalls while listing pediatric patients for heart transplantation, which is the standard of care for end-stage heart disease in children. Since the introduction of cyclosporine in the 1980s, the management in pediatric heart transplantation has shown consistent improvement, mainly because of technological advances and the integration of multidisciplinary teams in the field. However, the complexity of this patient population makes medical providers vulnerable to complications as a result of undesirable mistakes...
March 2018: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
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