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Remifentanil

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https://www.readbyqxmd.com/read/28924368/the-effects-of-perioperative-anesthesia-and-analgesia-on-immune-function-in-patients-undergoing-breast-cancer-resection-a-prospective-randomized-study
#1
Jin Sun Cho, Mi-Hyang Lee, Seung Il Kim, Seho Park, Hyung Seok Park, Ein Oh, Jong Ho Lee, Bon-Nyeo Koo
Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. We compared the effects of two different anesthesia and analgesia methods on the NK cell cytotoxicity (NKCC) in patients undergoing breast cancer surgery. Methods: Fifty patients undergoing breast cancer resection were randomly assigned to receive propofol-remifentanil anesthesia with postoperative ketorolac analgesia (Propofol-ketorolac groups) or sevoflurane-remifentanil anesthesia with postoperative fentanyl analgesia (Sevoflurane-fentanyl group)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28922338/does-the-%C3%AE-receptor-antagonist-esmolol-have-analgesic-effects-a-randomised-placebo-controlled-cross-over-study-on-healthy-volunteers-undergoing-the-cold-pressor-test
#2
Fredrik Ander, Anders Magnuson, Alex de Leon, Rebecca Ahlstrand
BACKGROUND: Esmolol may attenuate the sympathetic response to pain and reduce postoperative opioid consumption. It is not clear whether esmolol has an analgesic effect per se. OBJECTIVES: The aim of this study was to evaluate the analgesic effect of esmolol in the absence of anaesthetics and opioids. We tested the hypothesis that esmolol would reduce the maximum pain intensity perceived during the cold pressor test (CPT) by 2 points on a 0 to 10 numeric pain rating scale (NRS) compared to placebo...
September 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28916995/effects-of-environmental-enrichment-on-self-administration-of-the-short-acting-opioid-remifentanil-in-male-rats
#3
Rebecca S Hofford, Jonathan J Chow, Joshua S Beckmann, Michael T Bardo
BACKGROUND: Opioid abuse is a major problem around the world. Identifying environmental factors that contribute to opioid abuse and addiction is necessary for decreasing this epidemic. In rodents, environmental enrichment protects against the development of low dose stimulant self-administration, but studies examining the effect of enrichment and isolation (compared to standard housing) on the development of intravenous opioid self-administration have not been conducted. The present study investigated the role of environmental enrichment on self-administration of the short-acting μ-opioid remifentanil...
September 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28911241/correction-to-boztas-et-al-effects-of-different-doses-of-remifentanil-on-hemodynamic-response-to-anesthesia-induction-in-healthy-elderly-patients
#4
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28910303/the-influence-of-analgesic-based-sedation-protocols-on-delirium-and-outcomes-in-critically-ill-patients-a-randomized-controlled-trial
#5
Dan Liu, Jie Lyu, Huiying Zhao, Youzhong An
OBJECTIVE: To investigate the influence of analgesic-based midazolam sedation on delirium and outcomes in critically ill patients and to analyze the risk factors of delirium. DESIGN: Single center, prospective randomized controlled trial. SETTING: A surgical intensive care unit (ICU) in a tertiary care hospital in China. PATIENTS: Mechanically ventilated patients requiring sedation. MEASUREMENTS AND MAIN RESULTS: Patients admitted to the surgical intensive care unit who required sedation and were undergoing mechanical ventilation for longer than 24 hours were randomly divided into three groups: 1) the remifentanil group received remifentanil and midazolam, 2) the fentanyl group received fentanyl and midazolam, and 3) the control group received only midazolam...
2017: PloS One
https://www.readbyqxmd.com/read/28904684/anaesthetic-management-for-awake-craniotomy-in-brain-glioma-resection-initial-experience-in-military-hospital-mohamed-v-of-rabat
#6
Mohammed Meziane, Abdelghafour Elkoundi, Redouane Ahtil, Miloudi Guazaz, Bensghir Mustapha, Charki Haimeur
The awake brain surgery is an innovative approach in the treatment of tumors in the functional areas of the brain. There are various anesthetic techniques for awake craniotomy (AC), including asleep-awake-asleep technique, monitored anesthesia care, and the recent introduced awake-awake-awake method. We describe our first experience with anesthetic management for awake craniotomy, which was a combination of these techniques with scalp nerve block, and propofol/rémifentanil target controlled infusion. A 28-year-oldmale underwent an awake craniotomy for brain glioma resection...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28895379/the-analgesic-potency-dose-of-remifentanil-to-minimise-stress-response-induced-by-intubation-and-measurement-uncertainty-of-surgical-pleth-index
#7
Ji H Park, Dong-Hee Kim, Sun-Kook Yoo, Hyun-Jun Lim, Joo-Won Lee, Won-Sik Ahn, Eun-Kyung Lee, Byung-Moon Choi, Gyu-Jeong Noh
BACKGROUND: The aim of this study was to evaluate the analgesic potency dose of remifentanil to maintain surgical pleth index (SPI) values at less than 50 after intubation in patients undergoing general anaesthesia with target-controlled infusion of propofol and remifentanil. METHODS: We randomly allocated 120 patients to receive one of three remifentanil target effect-site concentrations (5, 7, or 9 ng⋅ml-1) during intubation. The target effect-site concentrations of propofol were adjusted within a range of 2...
September 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28891056/performance-of-the-minto-model-for-the-target-controlled-infusion-of-remifentanil-during-cardiopulmonary-bypass
#8
Y J Cho, W Y Jo, H Oh, C-H Koo, J Oh, J-Y Cho, K-S Yu, Y Jeon, T K Kim
We studied the predictive performance of the Minto pharmacokinetic model during cardiopulmonary bypass in patients undergoing cardiac surgery. Patients received remifentanil target-controlled infusion using the Minto model during total intravenous anaesthesia with propofol. From 56 patients, 275 arterial blood samples were drawn before, during and after bypass to determine the plasma concentration of remifentanil, and the predicted concentrations were recorded at each time. For pooled data, the median prediction error and median absolute prediction error were 21...
October 2017: Anaesthesia
https://www.readbyqxmd.com/read/28888583/fda-warning-on-anesthesia-and-brain-development-implications-for-obstetric-and-fetal-surgery
#9
Olutoyin A Olutoye, Byron Wycke Baker, Michael A Belfort, Oluyinka O Olutoye
There has been growing concern about the detrimental effects of certain anesthetic agents on the developing brain. Preclinical studies in small animal models as well as non-human primates, have suggested loss or death of brain cells and consequent impaired neurocognitive function following anesthetic exposure in neonates and late gestation fetuses. Human studies in this area are limited and currently inconclusive. On December 14, 2016, the United States Food and Drug administration (FDA) issued a warning regarding impaired brain development in children following exposure to certain anesthetic agents used for general anesthesia, namely the inhalational anesthetics isoflurane, sevoflurane, desflurane, and the intravenous agents, Propofol and midazolam, in the third trimester of pregnancy...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28886612/-remifentanil-up2date-part-2
#10
Stefan Bushuven, Sascha Kreuer, Peter Kranke
Remifentanil is a short-acting opioid of high analgetic potency and superior controllability. It is widely used in day-case surgery, procedural sedation, for reduction of recovery-times and obstetrics and whenever excellent controllability of opioid effects is needed. Especially in combination with propofol it is used for target controlled infusion (TCI). The second part of the article shows the differences between groups of patients regarding the use of remifentanil.
September 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28883672/comparison-of-different-analgesic-techniques-for-pain-relief-during-extracorporeal-shock-wave-lithotripsy-a-double-blind-randomized-clinical-trial
#11
Afsaneh Fouladi, Aria Soleimani
BACKGROUND: Most patients experience some degree of pain during extracorporeal shock waves lithotripsy (ESWL). AIM: The aim of this study was to evaluate the effect of target-controlled infusion (TCI) of remifentanil or sufentanil and patient-controlled analgesia (PCA) with sufentanil or morphine for pain relief during ESWL. MATERIALS AND METHODS: In a double blind, randomized clinical trial, a total of 60 patients who were scheduled for elective ESWL, randomly assigned into four groups (A, B, C and D)...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28882741/tracheal-extubation-with-suction-vs-positive-pressure-during-emergence-from-general-anaesthesia-in-adults-a-randomised-controlled-trial
#12
Joël L'Hermite, Olivier Wira, Chritel Castelli, Jean-Emmanuel de La Coussaye, Jacques Ripart, Philippe Cuvillon
BACKGROUND: After general anaesthesia (GA) in adults, the optimal tracheal extubation technique (positive pressure or suctioning) remains debated. The primary endpoint of this study was to assess the effects of these techniques on onset time of desaturation (SpO2 < 92%). METHODS: Sixty-nine patients with a body mass index < 30 scheduled for elective orthopaedic surgery were allocated to positive pressure (PP) or suctioning (SUC) group. GA was standardised with propofol and remifentanil via target-controlled infusion...
September 4, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28879331/dental-treatment-in-patients-with-severe-gag-reflex-using-propofol-remifentanil-intravenous-sedation
#13
Sooil Shin, Seungoh Kim
Patients with severe gag reflex (SGR) have difficulty getting the treatment they require in local clinics, and many tend to postpone the start of their treatment. To address this problem, dentists have used behavioral techniques and/or pharmacological techniques for treatment. Among the pharmacological methods available, propofol IV sedation is preferred over general anesthesia because it is a simpler procedure. Propofol in combination with remifentanil is characterized by stable sedative effects and quick recovery, leading to a deep sedation...
March 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28879314/protective-effects-of-remifentanil-against-h2o2-induced-oxidative-stress-in-human-osteoblasts
#14
Ji-Young Yoon, Do-Wan Kim, Eun-Jung Kim, Bong-Soo Park, Ji-Uk Yoon, Hyung-Joon Kim, Jeong-Hoon Park
BACKGROUND: Bone injury is common in many clinical situations, such as surgery or trauma. During surgery, excessive reactive oxygen species (ROS) production decreases the quality and quantity of osteoblasts. Remifentanil decreases ROS production, reducing oxidative stress and the inflammatory response. We investigated remifentanil's protective effects against H2O2-induced oxidative stress in osteoblasts. METHODS: To investigate the effect of remifentanil on human fetal osteoblast (hFOB) cells, the cells were incubated with 1 ng/ml of remifentanil for 2 h before exposure to H2O2...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28868576/choice-between-delayed-food-and-immediate-opioids-in-rats-treatment-effects-and-individual-differences
#15
Leigh V Panlilio, Maria E Secci, Charles W Schindler, Charles W Bradberry
RATIONALE: Addiction involves maladaptive choice behavior in which immediate drug effects are valued more than delayed nondrug rewards. OBJECTIVES AND METHODS: To model this behavior and extend our earlier work with the prescription opioid oxycodone, we allowed rats to choose between immediate intravenous delivery of the short-acting opioid remifentanil and delayed delivery of highly palatable food pellets. Treatment drugs were tested on a baseline where remifentanil was preferred over food...
September 4, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28868167/comparing-the-effects-of-combined-general-epidural-anaesthesia-and-general-anaesthesia-on-serum-cytokine-levels-in-radical-cystectomy
#16
Meltem Savran Karadeniz, Orkhan Mammadov, Hayriye Şentürk Çiftci, Sebahat Akgül Usta, Kamil Pembeci
OBJECTIVE: Surgical stress combined with general anaesthesia (GA) suppresses the immune system and leads to cancer cell growth and premature metastasis in major oncological interventions. Epidural analgesia decreases the need for inhalation agents and opioids during surgery by suppressing sympathetic and neuroendocrine responses in the postoperative period. This study aimed to compare the effects of combined general/epidural anaesthesia (GEA)+patient-controlled epidural analgesia (PCEA) and GA+IV patient-controlled analgesia (PCA) on serum tumour necrosis factor-alpha TNF-α), interleukin-1 beta (IL-1β) and interferon-gamma (IFN-γ) levels in patients undergoing radical cystectomy...
August 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28868139/the-choice-between-surgical-scrubbing-and-sterile-covering-before-or-after-induction-of-anaesthesia-a-prospective-study
#17
Irene Sellbrandt, Metha Brattwall, Pether Jildenstål, Margareta Warrén Stomberg, Jan Jakobsson
Background: Day surgery is increasing, and safe and effective logistics are sought. One part of the in-theatre logistics commonly discussed is whether surgical scrub and sterile covering should be done before or after induction of anaesthesia. The aim of the present study was to compare the impact of surgical scrub and sterile covering before vs. after the induction of anaesthesia in male patients scheduled for open hernia repair.    Methods: This is a prospective randomised study. Sixty ASA 1-3 patients scheduled for open hernia repair were randomised to surgical scrub and sterile covering before or after induction of anaesthesia; group "awake" and group "anaesthetised", respectively...
2017: F1000Research
https://www.readbyqxmd.com/read/28866689/reply-to-the-letter-to-the-editor-does-remifentanil-have-a-place-for-sedation-in-the-case-of-endotracheal-intubation-or-minimally-invasive-surfactant-therapy-in-neonates
#18
Ellen H M de Kort, Sinno H P Simons
No abstract text is available yet for this article.
September 2, 2017: Neonatology
https://www.readbyqxmd.com/read/28866673/does-remifentanil-have-a-place-for-sedation-in-the-case-of-endotracheal-intubation-or-minimally-invasive-surfactant-therapy-in-neonates
#19
Clément Chollat, Fabien Tourrel, Stéphane Marret
No abstract text is available yet for this article.
September 2, 2017: Neonatology
https://www.readbyqxmd.com/read/28856857/application-of-dexmedetomidine-remifentanil-in-high-intensity-ultrasound-ablation-of-uterine-fibroids-a-randomised-study
#20
X Fu, F Huang, Y Chen, Y Deng, Z Wang
OBJECTIVE: To compare the effects of dexmedetomidine-remifentanil with the traditional analgesia and sedation regimen midazolam-remifentanil during HIFU treatment of uterine fibroids. DESIGN: A randomised controlled trial. SETTING: Department of Anesthesia in a single hospital. POPULATION: Patients with uterine fibroids. METHODS: A total of 80 patients diagnosed with uterine fibroids and scheduled for selective HIFU treatment were randomly divided into the dexmedetomidine group (the D group) and midazolam group (the M group)...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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