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https://www.readbyqxmd.com/read/28635177/engineering-human-bone-grafts-with-new-macroporous-calcium-phosphate-cement-scaffolds
#1
Martina Sladkova, Michael Palmer, Caroline Öhman, Jiayi Cheng, Shoug Al-Ansari, Munerah Saad, Håkan Engqvist, Giuseppe Maria de Peppo
Bone engineering opens the possibility to grow large amounts of tissue products by combining patient-specific cells with compliant biomaterials. Decellularized tissue matrices represent suitable biomaterials but availability, long processing time, excessive cost, and concerns on pathogen transmission have led to the development of biomimetic synthetic alternatives. We recently fabricated calcium phosphate cement (CPC) scaffolds with variable macroporosity using a facile synthesis method with minimal manufacturing steps, and demonstrated long-term biocompatibility in vitro...
June 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28634845/histomorphometric-and-immunohistochemical-evaluation-of-collagen-containing-xenogeneic-bone-blocks-used-for-lateral-bone-augmentation-in-staged-implant-placement
#2
Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti, Mariano Sanz
BACKGROUND: The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. METHODS: In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28634368/preparation-and-properties-of-a-hyperbranch-structured-polyamine-adsorbent-for-carbon-dioxide-capture
#3
Hui He, Yajie Hu, Shuixia Chen, Linzhou Zhuang, Beibei Ma, Qinghua Wu
A fibrous adsorbent with amino-terminated hyperbranch structure (PP-AM-HBP-NH2) was prepared by grafting hyperbranched polyamine (HBP-NH2) onto the acrylamide-modified polypropylene (PP) fibers. The grafting of AM on PP fibers provided the active sites for introducing HBP-NH2 onto the PP fibers. This kind of "grafting to" procedure to synthesize hyperbranch-structured fiber could overcome the disadvantages of stepwise growth procedure, avoiding the complicated synthesis process and the requirement of strict experimental conditions...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631906/-technical-features-of-intestinal-ureteroplasty-part-7-forming-ureterointestinal-anastomoses
#4
B K Komyakov, V A Ochelenko, M V Onoshko, T Kh Al-Attar, A Kh Gaziev
AIM: To present the results and technical features of forming the ureterointestinal anastomoses in intestinal ureteral substitution. MATERIAL AND METHODS: From 1998 to December 2016, 168 patients (mean age 51 +/- 8.7 years) underwent ureteral substitution using intestinal segments at the Urology Clinic of the I.I. Mechnikov NWSMU. Of them, 76 (45.2%) were males. In 119 (70.8%) patients, intestinal segments were used to replace various parts of the ureters (iliac in 92, colonic in 4, appendix in 23), and in 49 (29...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631614/3d-printed-bioceramic-scaffolds-with-antibacterial-and-osteogenic-activity
#5
Yongliang Zhang, Dong Zhai, Mengchi Xu, Qingqiang Yao, Huiying Zhu, Jiang Chang, Chengtie Wu
Bacterial infection poses a significant risk with the wide application of bone graft materials. Designing bone grafts with good antibacterial performance and excellent bone-forming activity is of particular significance for bone tissue engineering. In our study, a 3D printing method was used to prepare β-tricalcium phosphate (β-TCP) bioceramic scaffolds. Silver (Ag) nanoparticles were uniformly dispersed on graphene oxide (GO) to form a homogeneous nanocomposite (named Ag@GO) with different Ag-to-graphene oxide mass ratios, with this being synthesized via the liquid chemical reduction approach...
June 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28626146/mitral-valve-structure-in-addition-to-myocardial-viability-determines-the-outcome-of-functional-mitral-regurgitation-after-coronary-artery-bypass-grafting
#6
Shohei Yoshida, Satsuki Fukushima, Shigeru Miyagawa, Teruya Nakamura, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Daisuke Yoshioka, Keitaro Domae, Noriyuki Kashiyama, Kouji Yamamoto, Ayumi Shintani, Satoshi Nakatani, Koichi Toda, Yoshiki Sawa
BACKGROUND: Coronary artery bypass grafting (CABG) reduces functional mitral regurgitation (MR) associated with ischemic heart disease, although the predictive factors or mechanisms of reversibility of functional MR after CABG are not fully understood.We investigated whether mitral valve structure is associated with the outcome of functional MR after CABG.Methods and Results:From a consecutive series of 98 patients with mild-moderate functional MR preoperatively who underwent isolated CABG, we enrolled 66 patients who were followed up for >1 year postoperatively using echocardiography...
June 16, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28624267/endoscopic-robot-assisted-c7-nerve-root-retrophalangeal-transfer-from-the-contralateral-healthy-side-a-cadaver-feasibility-study
#7
C Bijon, L Chih-Sheng, D Chevallier, N Tran, F Xavier, P Liverneaux
Controlateral C7 nerve root transfer in brachial plexus palsy requires a nerve graft and large incisions. This study investigated the feasibility of transferring the right C7 to the left C7 nerve root, without a graft, via a minimally invasive retropharyngeal approach. After installation of 6 trocars of 1cm diameter in the supraclavicular space, a Da Vinci SI(®) robot was placed. After locating the right brachial plexus, the C7 root was sectioned flush with the clavicle, transferred behind the pharynx and sutured to the left C7 root severed at the foramen level...
June 14, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28623079/restoration-of-articular-geometry-using-current-graft-options-for-large-glenoid-bone-defects-in-anterior-shoulder-instability
#8
Laurent B Willemot, Mohsen Akbari-Shandiz, Joaquin Sanchez-Sotelo, Kristin Zhao, Olivier Verborgt
PURPOSE: The purpose of this cadaveric study was to compare standard and modified coracoid transfer procedures, bicortical and tricortical iliac crest autografts, and tibial plafond and glenoid allografts with respect to glenoid surface curvature restoration. METHODS: Computed tomography scans of 8 cadaveric shoulders were acquired in 9 conditions: (1) intact, (2) 25% width defect, (3) classic Latarjet, (4) modified congruent-arc Latarjet, (5) tricortical iliac crest inner table, (6) outer table, (7) bicortical iliac crest, (8) distal tibia, and (9) glenoid allograft...
June 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28622604/tissue-engineered-hypertrophic-chondrocyte-grafts-enhanced-long-bone-repair
#9
Jonathan Bernhard, James Ferguson, Bernhard Rieder, Patrick Heimel, Thomas Nau, Stefan Tangl, Heinz Redl, Gordana Vunjak-Novakovic
Bone has innate ability to regenerate following injury. However, large and complex fractures exceed bone's natural repair capacity and result in non-unions, requiring external intervention to facilitate regeneration. One potential treatment solution, tissue-engineered bone grafts, has been dominated by recapitulating intramembranous ossification (bone formation by osteoblasts), although most serious bone injuries heal by endochondral ossification (bone formation by remodeling of hypertrophic cartilaginous anlage)...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28619543/circumferential-three-dimensional-printed-tracheal-grafts-research-model-feasibility-and-early-results
#10
Faiz Y Bhora, Erik E Lewis, Sadiq S Rehmani, Adil Ayub, Wissam Raad, Adnan M Al-Ayoubi, Robert S Lebovics
BACKGROUND: Methods for tracheal graft research have presented persistent challenges to investigators, and three-dimensional (3D)-printed biosynthetic grafts offer one potential development platform. We aimed to develop an efficient research platform for customizable circumferential 3D-printed tracheal grafts and evaluate feasibility and early structural integrity with a large-animal model. METHODS: Virtual 3D models of porcine subject tracheas were generated using preoperative computed tomography scans...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28615818/minimising-the-donor-area-morbidity-of-radial-forearm-phalloplasty-using-prefabricated-thigh-flap-a-new-technique
#11
Aditya Aggarwal, Hardeep Singh, Sanjay Mahendru, Vimalendu Brajesh, Sukhdeep Singh, Nitin Ghag, Rakesh Kumar Khazanchi
Phalloplasty is indicated in various conditions of penile loss or absence. There are numerous techniques for phalloplasty including the pedicle and free flaps with the ultimate goal of micturition in standing position, attaining adequate size, aesthesis and sensations for sexual intercourse. Radial forearm phalloplasty is the gold standard flap to achieve above results but gives a very bad scar on the forearm. We present a technique of using prefabricated thigh flap to reduce the morbidity of donor area. The descending branch of lateral circumflex femoral pedicle was placed in a subcutaneous plane over tissue expander...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28612149/35-year-experience-with-surgical-treatment-of-hidradenitis-suppurativa
#12
Richard E Burney
BACKGROUND: Hidradenitis suppurativa is a painful and disfiguring chronic inflammatory condition affecting both men and women. Medical treatments, such as antibiotics and immunosuppressive agents, are often ineffective. Over time, patients can suffer from recurrent abscesses, chronic purulent drainage, scarring, and contractures that can only be corrected by surgical excision. There is no agreement, however, on the best way for the surgeon to manage this condition. The purpose of this review is to describe the results of surgical treatment of this condition in a large cohort of patients managed by local excision of hidradenitis, healing by secondary intention and reoperation as needed...
June 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28612026/postoperative-compensatory-ammonium-excretion-subsequent-to-systemic-acidosis-in-cardiac-patients
#13
Friederike Roehrborn, Daniel-Sebastian Dohle, Indra N Waack, Konstantinos Tsagakis, Heinz Jakob, Johanna K Teloh
BACKGROUND: Postoperative acid-base imbalances, usually acidosis, frequently occur after cardiac surgery. In most cases, the human body, not suffering from any severe preexisting illnesses regarding lung, liver, and kidney, is capable of transient compensation and final correction. The aim of this study was to correlate the appearance of postoperatively occurring acidosis with renal ammonium excretion. MATERIALS AND METHODS: Between 07/2014 and 10/2014, a total of 25 consecutive patients scheduled for elective isolated coronary artery bypass grafting with cardiopulmonary bypass were enrolled in this prospective observational study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28611187/comparing-outcomes-of-coronary-artery-bypass-grafting-among-large-teaching-and-urban-hospitals-in-china-and-the-united-states
#14
Zhe Zheng, Heng Zhang, Xin Yuan, Chenfei Rao, Yan Zhao, Yun Wang, Sharon-Lise Normand, Harlan M Krumholz, Shengshou Hu
BACKGROUND: Coronary artery disease is prevalent in China, with concomitant increases in the volume of coronary artery bypass grafting (CABG). The present study aims to compare CABG-related outcomes between China and the United States among large teaching and urban hospitals. METHODS AND RESULTS: Observational analysis of patients aged ≥18 years, discharged from acute-care, large teaching and urban hospitals in China and the United States after hospitalization for an isolated CABG surgery...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28610931/can-cyst-volume-be-used-to-stratify-risk-of-complications-following-cyst-defect-reconstruction-with-iliac-crest-graft
#15
Ali-Farid Safi, Andrea Grandoch, Timo Dreiseidler, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
INTRODUCTION: The role of the volume of radicular and dentigerous cysts on clinical symptoms is unclear and potentially may predict development of pre- and postoperative complications, especially after cystectomies with large bony defects. Therefore the aim of this study was to assess pre- and postoperative symptoms associated to the volume of jaw cysts. MATERIAL AND METHODS: Retrospective chart review of 111 patients with follicular or dentigerous cysts from 2008-2012...
May 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28610885/three-dimensional-printed-bioengineered-tracheal-grafts-preclinical-results-and-potential-for-human-use
#16
Sadiq S Rehmani, Adnan M Al-Ayoubi, Adil Ayub, Michael Barsky, Erik Lewis, Raja Flores, Robert Lebovics, Faiz Y Bhora
BACKGROUND: We aimed to develop a process using three-dimensional (3D) printing to create bioengineered tracheal grafts (BETGs) for reconstruction of anterior tracheal defects in a large-animal model (porcine) that would have translational relevance for potential human use. METHODS: Preoperative computed tomographic scans were used to create virtual 3D models of the animal airways. Anatomically scaled tracheal grafts were subsequently developed using 3D-printed polycaprolactone and extracellular matrix...
June 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28609850/evaluation-of-the-starch-based-flocculants-on-flocculation-of-hairwork-wastewater
#17
Qing Du, Hua Wei, Aimin Li, Hu Yang
China is the world's largest producer of wigs, and the manufacturing generates large quantities of hairwork effluents. Coagulation/flocculation is an important step in the water treatment process. In this study, two versions of starch-based flocculants were successfully prepared through etherification and graft copolymerization, respectively. Starch-3-chloro-2-hydroxypropyl triethyl ammonium chloride (St-CTA-DQ) and starch-graft-poly[(2-methacryloyloxyethyl) trimethyl ammonium chloride] (St-g-PDMC-DQ) both contain strongly cationic quaternary ammonium salt groups, but have differing cationic contents, specifically, the degree of substitution (DS) and grafting ratio (G)...
June 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28608325/pulsatile-flow-leads-to-intimal-flap-motion-and-flow-reversal-in-an-in-vitro-model-of-type-b-aortic-dissection
#18
Joav Birjiniuk, Lucas H Timmins, Mark Young, Bradley G Leshnower, John N Oshinski, David N Ku, Ravi K Veeraswamy
Understanding of the hemodynamics of Type B aortic dissection may improve outcomes by informing upon patient selection, device design, and deployment strategies. This project characterized changes to aortic hemodynamics as the result of dissection. We hypothesized that dissection would lead to elevated flow reversal and disrupted pulsatile flow patterns in the aorta that can be detected and quantified by non-invasive magnetic resonance imaging. Flexible, anatomic models of both normal aorta and dissected aorta, with a mobile intimal flap containing entry and exit tears, were perfused with a physiologic pulsatile waveform...
June 12, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28607778/saphenovenous-graft-aneurysm-a-rare-complication-of-cabg
#19
James Thomas Connell
Saphenovenous graft aneurysm is a rare complication of coronary artery bypass grafts that is likely underdiagnosed. It is typically asymptomatic, slow growing, and often diagnosed incidentally on angiography or following catastrophic rupture. There is no consensus on best management but PCI and surgery appear to have more favourable mortality outcomes relative to conservative management. We present the case of a 48-year-old male with a cardiovascular risk profile hallmarked by diabetes mellitus, end stage renal failure, recalcitrant hyperlipidaemia, and IHD previously treated with CABG...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28607133/loss-of-thymic-innate-lymphoid-cells-leads-to-impaired-thymopoiesis-in-experimental-graft-vs-host-disease
#20
Jarrod A Dudakov, Anna M Mertelsmann, Margaret H O'Connor, Robert R Jenq, Enrico Velardi, Lauren F Young, Odette M Smith, Richard L Boyd, Marcel R M van den Brink, Alan M Hanash
Graft vs. host disease (GVHD) and post-transplant immunodeficiency are frequently related complications of allogeneic hematopoietic transplantation. Alloreactive donor T cells can damage thymic epithelium, thus limiting new T cell development. While the thymus has a remarkable capacity to regenerate after injury, endogenous thymic regeneration is impaired in GVHD. The mechanisms leading to this regenerative failure are largely unknown. Here we demonstrate in experimental mouse models that GVHD results in depletion of intrathymic group 3 innate lymphoid cells (ILC3s) necessary for thymic regeneration...
June 12, 2017: Blood
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