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Gulsum Uysal, Hatice Akkaya, Fulya Cagli, Sadan Tutus, Ahter T Tayyar
Pain relief of two different oral contraceptive pills (OCPs) in severe primary dysmenorrhoea (PD) was compared. Sixty-six nulliparous patients with severe PD requiring contraception were evaluated. Group 1 comprised 33 healthy controls. Patients with severe PD were divided into two groups. Patients in Group 2 were administered oestradiol valerate/dienogest and patients in Group 3 were administered ethinylestradiol/drospirenone. Doppler indices of both uterine arteries (left and right) including systolic/diastolicrates (S/D), pulsatility index (PI) and resistance index (RI) were measured, and a visual analogue scale (VAS) was applied to patients before treatment...
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Takenobu Ishii, Montserrat Ruiz-Torruella, Atsushi Ikeda, Satoru Shindo, Alexandru Movila, Hani Mawardi, Abdullah Albassam, Rayyan A Kayal, Ayman A Al-Dharrab, Kenji Egashira, Wichaya Wisitrasameewong, Kenta Yamamoto, Abdulghani I Mira, Kenji Sueishi, Xiaozhe Han, Martin A Taubman, Takeshi Miyamoto, Toshihisa Kawai
Cell fusion-mediated formation of multinuclear osteoclasts (OCs) plays a key role in bone resorption. It is reported that 2 unique OC-specific fusogens [ i.e., OC-stimulatory transmembrane protein (OC-STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP)], and permissive fusogen CD9, are involved in OC fusion. Contrast to DC-STAMP of which knockout (KO) mice show osteopetrotic phenotype, OC-STAMP-KO mice show no difference in systemic bone mineral density. Nonetheless, according to the ligature-induced periodontitis model, significantly lower level of bone resorption was found in OC-STAMP-KO mice compared to WT mice...
March 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Neidin Eustace, Kiran M Sarma, Jane Murphy, Gerard J Molloy
We examine the association between a six-facet model of conscientiousness and adherence to the Oral Contraceptive Pill (OCP), to investigate if these 6 facets can account for variation in adherence to the OCP. Cross-sectional data were collected from an opportunity sample of 243 female participants who were current users of the OCP, via online survey. Data were analysed using correlation and standard regression. The 60-item Chernyshenko Conscientiousness Scale (CCS), the 10-item IPIP Conscientiousness (IPIP C) subscale and the 5-item OCP Medication Adherence Report Scale (MARS) were employed...
March 13, 2018: Psychology, Health & Medicine
Quan Zhang, Ximing Wang, Jianqiang Zhu, Zhe Li, Ye Wang
The Grand Canal is one of the most important waterways and sources of drinking water in China. The security of this water environment has a strong influence on national economic development and public health. However, data on the pollution status and potential risks due to persistent organic pollutants (POPs) in this area is insufficient. In this study, we selected a branch of the Grand Canal in Hangzhou as the study subject from which 16 surface water samples were collected in the summer of 2016. The concentrations of organochlorine pesticides (OCPs) (including 4 hexachlorocyclohexanes (HCHs) and 6 dichlorodiphenyltrichloroethanes (DDTs)), 12 polycyclic aromatic hydrocarbons (PAHs), and 35 polychlorinated biphenyls (PCBs) in the water samples were determined by gas chromatography-mass spectrometry (GC-MS)...
March 12, 2018: Environmental Monitoring and Assessment
Feriel Boussema, Andrew J Gross, Fatma Hmida, Brahim Ayed, Hatem Majdoub, Serge Cosnier, Abderrazak Maaref, Michael Holzinger
Two new inorganic-organic hybrid materials based on heteropolyoxometalates (POMs): (C4 H10 N)6 [P2 Mo18 O62 ]·4H2 O (P2 Mo18 ) and (C6 H8 NO)4 [H2 P2 W18 O62 ]·6H2 O (P2 W18 ) are reported as mediators for electron transfer between FAD-dependent glucose dehydrogenase (FAD-GDH) and a multiwalled carbon nanotube (MWCNT) matrix for glucose biofuel cell and biosensor applications. These polyoxometalates were chosen due to their promising redox behavior in a potential range for mediated electron transfer with the glucose oxidizing enzyme, FAD-GDH...
February 28, 2018: Biosensors & Bioelectronics
Yury B Slonimskiy, Eugene G Maksimov, Evgeny P Lukashev, Marcus Moldenhauer, Cy M Jeffries, Dmitri I Svergun, Thomas Friedrich, Nikolai N Sluchanko
Photosynthesis requires a balance between efficient light harvesting and protection against photodamage. The cyanobacterial photoprotection system uniquely relies on the functioning of the photoactive orange carotenoid protein (OCP) that under intense illumination provides fluorescence quenching of the light-harvesting antenna complexes, phycobilisomes. The recently identified fluorescence recovery protein (FRP) binds to the photoactivated OCP and accelerates its relaxation into the basal form, completing the regulatory circle...
March 7, 2018: Biochimica et Biophysica Acta
N N Sluchanko, Y B Slonimskiy, E G Maksimov
Photoprotective mechanisms of cyanobacteria are characterized by several features associated with the structure of their water-soluble antenna complexes - the phycobilisomes (PBs). During energy transfer from PBs to chlorophyll of photosystem reaction centers, the "energy funnel" principle is realized, which regulates energy flux due to the specialized interaction of the PBs core with a quenching molecule capable of effectively dissipating electron excitation energy into heat. The role of the quencher is performed by ketocarotenoid within the photoactive orange carotenoid protein (OCP), which is also a sensor for light flux...
December 2017: Biochemistry. Biokhimii︠a︡
Patricia Barrionuevo, Mohammed Nabhan, Osama Altayar, Zhen Wang, Patricia J Erwin, Noor Asi, Kathryn A Martin, M Hassan Murad
Background: Several pharmacologic treatments for hirsutism are used in practice; however, their relative efficacy is unclear. Methods: We searched MEDLINE, EMBASE, and CENTRAL through January 2017 for randomized controlled trials (RCTs) with follow-up of at least 6 months that evaluated antiandrogens, insulin sensitizers, and oral contraceptives in women with hirsutism. Independent pairs of reviewers selected and appraised trials. Random-effects network meta-analysis was used to compare individual drugs and classes...
March 7, 2018: Journal of Clinical Endocrinology and Metabolism
Lina Ma, Caiyun You, Mikhail Hernandez, Arash Maleki, Andres Lasave, Alexander Schmidt, Andrew Stephenson, Thongzen Zhao, Stephen Anesi, C Stephen Foster
PURPOSE: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP). METHODS: A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. IVIg infusion was 2g/kg/cycle administered in 3 consecutive days monthly. RESULTS: Of 512 OCP patients, 17 patients (34 eyes) treated with IVIg monotherapy were identified...
March 8, 2018: Ocular Immunology and Inflammation
Sultana Monira Hussain, Yuanyuan Wang, Graham G Giles, Stephen Graves, Anita E Wluka, Flavia M Cicuttini
OBJECTIVES: To examine the associations of female reproductive and hormonal factors with incidence of total knee arthroplasty (TKA) for osteoarthritis, and whether the associations differ according to overweight/obesity status. DESIGN: This study included 22,289 women in the Melbourne Collaborative Cohort Study. Data on age at menarche, pregnancy, parity, years of menstruation, oral contraceptive pill (OCP), menopausal status and hormone replacement therapy (HRT) were collected in 1990-1994...
March 7, 2018: Arthritis & Rheumatology
Omar Toumi, Mohamed Ali Chaouch, Abdesslem Ghedira, Ibtissem Korbi, Mohamed Nasr, Faouzi Noomene, Khadija Zouari, Randa Salem, Badii Hamida, Mondher Golli
INTRODUCTION: Congenital bile duct cysts (CBDC) is a rare congenital malformation. It results from an anomaly of the biliopancreatic junction (AJBP). This condition is often diagnosed at a young age. Although, it can be asymptomatic and discovered only at an advanced age. The aim of our work was to describe the diagnosis, therapeutic and evolutionary aspects of BVCD through a series of 11 cases diagnosed in adult cases. METHODS: This is a descriptive, retrospective and monocentric study...
June 2017: La Tunisie Médicale
Jordan Stubleski, Petr Kukucka, Samira Salihovic, P Monica Lind, Lars Lind, Anna Kärrman
The objective of this study was to develop and validate a 96-well plate solid phase extraction method for analysis of 23 lipophilic persistent organic pollutants (POPs) in low-volume plasma and serum samples which is applicable for biomonitoring and epidemiological studies. The analysis of selected markers for internal exposure: 16 polychlorinated biphenyls (PCBs), 5 organochlorine pesticides (OCPs), octachlorinated dibenzo-p-dioxin (OCDD), and polybrominated diphenylether 47 (BDE 47) was evaluated by comparing two SPE sorbents and GC-HRMS or GC-MS/MS detection...
February 27, 2018: Journal of Chromatography. A
Hansjörg Grützmacher, Yanbo Mei, Dong-Jun Wu, Jaap Borger
A simple synthesis of sodium 2-phosphanaphthalene-3-olate (1) based on the extrusion of N2 from phthalazine using Na[OCP] is reported. This heterocycle can be readily functionalized at the negatively charged oxygen center through using a variety of electrophilic substrates. The coordination chemistry of both 1 and its neutral derivatives was explored revealing their facile use as P-donor ligands for late transition metal complexes.
March 6, 2018: Angewandte Chemie
Balram Pokhrel, Ping Gong, Xiaoping Wang, Mengke Chen, Chuanfei Wang, Shaopeng Gao
Due to the high temperature and extensive use of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), tropical cities could act as secondary sources of these pollutants and therefore received global concern. As compared with other tropical cities, studies on the air-soil exchange of OCPs, PCBs and PAHs in tropical Nepali cities remained limited. In the present study, 39 soil samples from Kathmandu (capital of Nepal) and 21 soil samples from Pokhara (second largest city in Nepal) were collected The soil concentrations of the sum of endosulfans (α- and β-endosulfans) ranged from 0...
February 20, 2018: Chemosphere
N B Svendsen, D Herzke, M Harju, C Bech, G W Gabrielsen, V L B Jaspers
Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs) and organophosphate esters (OPEs) were assessed in blood plasma and feathers of 19 adult black-legged kittiwakes (Rissa tridactyla) breeding in two colonies (Blomstrandhalvøya and Krykkjefjellet) at the Arctic archipelago, Svalbard. Potential associations with body condition index (BCI) and thyroid hormones were investigated. All compound classes were detected in both blood plasma and feathers, but due to low sample size and volumes, OPEs could only be quantified in four individuals, warranting larger follow-up studies...
February 27, 2018: Environmental Research
Ying-Chang Li, Yuan-Hsiao Chang, Preetpal Singh, Liann-Be Chang, Der-Hwa Yeh, Ting-Yu Chao, Si-Yun Jian, Yu-Chi Li, Cher Ming Tan, Chao-Sung Lai, Lee Chow, Shang-Ping Ying
The light emitting diode (LED) is widely used in modern solid-state lighting applications, and its output efficiency is closely related to the submounts' material properties. Most submounts used today, such as low-power printed circuit boards (PCBs) or high-power metal core printed circuit boards (MCPCBs), are not transparent and seriously decrease the output light extraction. To meet the requirements of high light output and better color mixing, a three-dimensional (3-D) stacked flip-chip (FC) LED module is proposed and demonstrated...
March 1, 2018: Materials
Guido Noé Rimondino, Ana Julieta Pepino, Martín Diego Manetti, Luis Olcese, Gustavo Alejandro Argüello
Long-range atmospheric transport is one of the most important ways in which persistent organic pollutants can be transported from their source to remote and pristine regions. Here, we report the results of the first Argentinian measurements of organochlorine pesticides in the Antarctic region. During a 9665-km track onboard OV ARA Puerto Deseado, within the framework of Argentinian Antarctic Expeditions, air samples were taken using high-volume samplers and analyzed using GC-μECD. HCB, HCHs, and endosulfans were the major organic pollutants found, and a north-south gradient in their concentrations was evident by comparing data from the Argentinian offshore zone to the South Scotia Sea...
February 26, 2018: Environmental Science and Pollution Research International
Bhavita Walia, Elizabeth Lingenheld, Le Duong, Archana Sanjay, Hicham Drissi
Osteoporosis management is currently centered around bisphosphonates, which inhibit osteoclast (OC) bone resorption but do not affect bone formation. This reduces fracture risk, but fails to restore healthy bone remodeling. Studies in animal models showed that cathepsin K (CatK) inhibition by genetic deletion or chemical inhibitors maintained bone formation while abrogating resorption during bone remodeling and stimulated periosteal bone modeling. Recently, periosteal mononuclear tartrate-resistant acid phosphatase-positive (TRAP+ ) osteoclast precursors (OCPs) were shown to augment angiogenesis-coupled osteogenesis...
February 26, 2018: Annals of the New York Academy of Sciences
Dianshan Ke, Xiaomin Fu, Ying Xue, Haojie Wu, Yang Zhang, Xinwei Chen, Jianming Hou
Interleukin-17A(IL-17A), a proinflammatory cytokine, may have effects on osteoclastic resorption in inflammation-mediated bone loss, including postmenopausal osteoporosis. IL-17A could alter autophagic activity among other tissues and cells, thereby causing corresponding lesions. The aim of this study was to clarify how IL-17A influenced osteoclastogenesis by regulating autophagy. The present study showed that IL-17A could facilitate osteoclast precursors (OCPs) autophagy and osteoclastogenesis at a low concentration...
February 21, 2018: Biochemical and Biophysical Research Communications
Wihan Pheiffer, Nico J Wolmarans, Ruan Gerber, Yared B Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka, Nico J Smit, Victor Wepener, Rialet Pieters
Organochlorine pesticides (OCPs) in South Africa have for the most part been banned, except dichlorodiphenyltrichloroethane (DDT) which is still used as malaria vector control. The aim of this study was to determine OCP residues in the aquatic fauna of one of South Africa's most populated areas, Soweto. Risk to human health through OCP exposure via fish consumption was investigated. Clarias gariepinus was chosen as bioindicator because it is an apex predator that is in abundance, but is also a valued food source...
February 13, 2018: Science of the Total Environment
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