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https://www.readbyqxmd.com/read/29149658/evaluating-casama-contextualized-semantic-maps-for-summarization-of-lung-cancer-studies
#1
Jean I Garcia-Gathright, Nicholas J Matiasz, Carlos Adame, Karthik V Sarma, Lauren Sauer, Nova F Smedley, Marshall L Spiegel, Jennifer Strunck, Edward B Garon, Ricky K Taira, Denise R Aberle, Alex A T Bui
OBJECTIVE: It is crucial for clinicians to stay up to date on current literature in order to apply recent evidence to clinical decision making. Automatic summarization systems can help clinicians quickly view an aggregated summary of literature on a topic. Casama, a representation and summarization system based on "contextualized semantic maps," captures the findings of biomedical studies as well as the contexts associated with patient population and study design. This paper presents a user-oriented evaluation of Casama in comparison to a context-free representation, SemRep...
November 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29149644/assessing-the-risk-of-laparoscopic-morcellation-of-occult-uterine-sarcomas-during-hysterectomy-and-myomectomy-literature-review-and-the-isge-recommendations
#2
REVIEW
Ornella Sizzi, Lucia Manganaro, Alfonso Rossetti, Matteo Saldari, Giuseppe Florio, Alessandro Loddo, Robert Zurawin, Bruno van Herendael, Dusan Djokovic
OBJECTIVE: This project of the International Society for Gynecologic Endoscopy (ISGE) had the objective to review the literature and provide recommendations on the occult sarcoma risk assessment in patients who are candidates for minimally invasive gynecological surgery involving intra-abdominal electromechanical tissue morcellation. STUDY DESIGN: The ISGE Task Force for Estimation of the Risk in Endoscopic Morcellation initially defined key topics and clinical questions which may guide a comprehensive preoperative patient assessment...
November 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29149574/transscleral-passive-and-iontophoretic-transport-theory-and-analysis
#3
S Kevin Li, Jinsong Hao
INTRODUCTION: The sclera is considered the "static barrier," a main barrier for transscleral drug delivery. The characterization of passive and iontophoretic transport across the sclera in vitro is the first step towards our ability to predict transscleral drug delivery. Although previous studies have investigated this topic, the quantitative structure permeation relationships (QSPR) for passive and iontophoretic transscleral transport are not available. AREAS COVERED: This review evaluated previous passive permeation and iontophoresis results of transscleral transport in vitro and examined QSPR for transscleral permeation of small permeants and macromolecules...
November 17, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#4
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29149397/heavily-graphitic-nitrogen-self-doped-high-porosity-carbon-for-the-electrocatalysis-of-oxygen-reduction-reaction
#5
Tong Feng, Wenli Liao, Zhongbin Li, Lingtao Sun, Dongping Shi, Chaozhong Guo, Yu Huang, Yi Wang, Jing Cheng, Yanrong Li, Qizhi Diao
Large-scale production of active and stable porous carbon catalysts for oxygen reduction reaction (ORR) from protein-rich biomass became a hot topic in fuel cell technology. Here, we report a facile strategy for synthesis of nitrogen-doped porous nanocarbons by means of a simple two-step pyrolysis process combined with the activation of zinc chloride and acid-treatment process, in which kidney bean via low-temperature carbonization was preferentially adopted as the only carbon-nitrogen sources. The results show that this carbon material exhibits excellent ORR electrocatalytic activity, and higher durability and methanol-tolerant property compared to the state-of-the-art Pt/C catalyst for the ORR, which can be mainly attributed to high graphitic-nitrogen content, high specific surface area, and porous characteristics...
November 17, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29149385/pre-clinical-models-in-pediatric-traumatic-brain-injury-challenges-and-lessons-learned
#6
REVIEW
Patrick M Kochanek, Jessica S Wallisch, Hülya Bayır, Robert S B Clark
PURPOSE: Despite the enormity of the problem and the lack of new therapies, research in the pre-clinical arena specifically using pediatric traumatic brain injury (TBI) models is limited. In this review, some of the key models addressing both the age spectrum of pediatric TBI and its unique injury mechanisms will be highlighted. Four topics will be addressed, namely, (1) unique facets of the developing brain important to TBI model development, (2) a description of some of the most commonly used pre-clinical models of severe pediatric TBI including work in both rodents and large animals, (3) a description of the pediatric models of mild TBI and repetitive mild TBI that are relatively new, and finally (4) a discussion of challenges, gaps, and potential future directions to further advance work in pediatric TBI models...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#7
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149098/early-versus-late-surgical-correction-in-congenital-diaphragmatic-hernia
#8
Alexandra Yunes, Matías Luco, Juan Carlos Pattillo
INTRODUCTION: The timing of surgical repair in patients with congenital diaphragmatic hernia has been a controversial topic over the years, and there is still no agreement as to whether immediate repair or late surgery with preoperative stabilization is preferable. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
November 15, 2017: Medwave
https://www.readbyqxmd.com/read/29148835/2017-white-paper-on-recent-issues-in-bioanalysis-aren-t-bmv-guidance-guidelines-scientific-part-1-lcms-small-molecules-peptides-and-small-molecule-biomarkers
#9
Jan Welink, Eric Yang, Nicola Hughes, Brian Rago, Eric Woolf, Jens Sydor, Laura Coppola, Brad Ackermann, Wenkui Li, Stephen C Alley, Mark Arnold, Isabella Berger, Chad Briscoe, Michael Buonarati, Mark Bustard, Mark Cancilla, Seongeun Julia Cho, Jeff Duggan, Daniela Fraier, Fabio Garofolo, Rachel Green, Sam Haidar, Lucinda Hittle, Akiko Ishii-Watabe, Rafiq Islam, Rand Jenkins, Barry Jones, John Kadavil, Sean Kassim, Olga Kavetska, Olivier Le Blaye, Anita Lee, Hanlan Liu, John Mehl, Gustavo Mendes Lima Santos, Adrien Musuku, Ragu Ramanathan, Yoshiro Saito, Natasha Savoie, Scott Summerfield, Sekhar Surapaneni, Matthew Szapacs, Nilufer Tampal, Tom Verhaeghe, Stephen Vinter, Emma Whale
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis, Biomarkers and Immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecule analysis involving LCMS, hybrid LBA/LCMS and ligand-binding assay (LBA) approaches...
November 17, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29148574/effects-of-high-temperatures-and-drought-during-anthesis-and-grain-filling-period-on-wheat-processing-quality-and-underlying-gluten-structural-changes
#10
Jasna Mastilović, Dragan Živančev, Eva Lončar, Radomir Malbaša, Nikola Hristov, Žarko Kevrešan
BACKGROUND: Climate changes do not only affect wheat yield, but also its quality. The information on this topic gathered so far is somewhat contradictory and insufficient. Climate changes are also affecting wheat indirectly through their influence on the ecosystem, including insects and fungi that affect the wheat technological quality. The aim of this study has been to examine trends in structural and technological changes of wheat quality under conditions typical of climate changes...
November 17, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29148423/non-invasive-vascular-biomarkers-in-patients-with-beh%C3%A3-et-s-disease-review-of-the-data-and-future-perspectives
#11
REVIEW
Athanase D Protogerou, Efthimia G Nasothimiou, Petros P Sfikakis, Athanasios G Tzioufas
Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management...
October 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148401/vitamin-d-and-systemic-lupus-erythematous-a-review-of-immunological-and-clinical-aspects
#12
REVIEW
Francesca Dall'Ara, Maurizio Cutolo, Laura Andreoli, Angela Tincani, Sabrina Paolino
OBJECTIVES: To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation. METHODS: The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. The focus was mainly on studies with implications on every day clinical practice...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148139/nitroglycerin-an-unusual-solution-to-intraoperative-hypothermia-in-a-4-year-old-burn-patient
#13
Eduardo J Goenaga Díaz, Jeffrey E Carter, T Wesley Templeton
We describe the case of a 4-year-old child undergoing extensive burn surgery with refractory intraoperative hypothermia. A low-dose nitroglycerin infusion was initiated to reverse vasoconstriction and improve heat absorption, after which the child's temperature steadily improved. In hypothermic burn patients, topical vasoconstrictors may hinder surface warming efforts. A vasodilator infusion may aid in warming the pediatric patient undergoing extensive excision and grafting.
November 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29148110/stress-and-ways-of-coping-among-nurse-managers-an-integrative-review
#14
REVIEW
Leodoro J Labrague, Denise M McEnroe-Petitte, Michael Leocadio, Peter Van Bogaert, Greta G Cummings
AIMS AND OBJECTIVES: To appraise and synthesize empirical studies examining sources of occupational stress and ways of coping utilized by Nurse Managers (NMs) when dealing with stress. BACKGROUND: The Nurse Manager's role is challenging yet draining and stressful and has adverse consequences on an individual's overall health and well -being, patients' outcomes, and organizational productivity. Considerable research has been done; however, an updated and broader perspective on this critical organizational issue has not been performed...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29148075/job-satisfaction-work-environment-and-successful-aging-determinants-of-delaying-retirement-among-acute-care-nurses
#15
Michele Wargo-Sugleris, Wendie Robbins, Christianne Joy Lane, Linda R Phillips
AIM: To determine the relationships between job satisfaction, work environment and successful aging and how these factors relate to Registered Nurses' intent to retire. BACKGROUND: Although little studied, retention of older nurses by delaying early retirement, before age 65, is an important topic for research. Qualitative and quantitative studies have indicated that job satisfaction work environment and successful aging are key motivators in acute care Registered Nursesretention and/or delaying retirement...
November 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#16
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29148044/the-incidence-of-bent-dorsal-fins-in-free-ranging-cetaceans
#17
F Alves, J R Towers, R W Baird, G Bearzi, S Bonizzoni, R Ferreira, Z Halicka, A Alessandrini, A H Kopelman, C Yzoard, M H Rasmussen, C G Bertulli, E Jourdain, A Gullan, D Rocha, K Hupman, M-T Mrusczok, F I P Samarra, S Magalhães, C R Weir, J K B Ford, A Dinis
Laterally bent dorsal fins are rarely observed in free-ranging populations of cetaceans, contrary to captivity, where most killer whale Orcinus orca adult males have laterally collapsed fins. This topic has been poorly explored, and data/information on its occurrence and possible causes are limited. The present study: (i) undertakes a review of the available information on bent dorsal fins in free-ranging cetaceans, and updates it with new records, (ii) reports on the proportion of bent fins in different study populations, and (iii) discusses possible causes...
November 17, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29147942/randomized-controlled-trials-of-simulation-based-interventions-in-emergency-medicine-a-methodological-review
#18
REVIEW
Anthony Chauvin, Jennifer Truchot, Aida Bafeta, Dominique Pateron, Patrick Plaisance, Youri Yordanov
The number of trials assessing Simulation-Based Medical Education (SBME) interventions has rapidly expanded. Many studies show that potential flaws in design, conduct and reporting of randomized controlled trials (RCTs) can bias their results. We conducted a methodological review of RCTs assessing a SBME in Emergency Medicine (EM) and examined their methodological characteristics. We searched MEDLINE via PubMed for RCT that assessed a simulation intervention in EM, published in 6 general and internal medicine and in the top 10 EM journals...
November 16, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29147859/initial-psycho-oncological-counselling-in-neuro-oncology-analysis-of-topics-and-needs-of-brain-tumour-patients
#19
Stephanie Schipmann, Eric Suero Molina, Anna Frasch, Walter Stummer, Dorothee Wiewrodt
Diagnosis of a brain tumour is associated with a tremendous disruption of emotional, physical and social well-being. Due to the complexity of the disease and the affection of the central organ, the brain, brain tumour patients differ from other cancer patients. The purpose of this study was to evaluate the concerns and burdens presented by brain tumour patients during their initial psycho-oncological consultation. We performed a retrospective analysis of 53 patients with the diagnosis of either benign or malignant brain tumour, seeking counsel by a neurosurgeon specialised in psycho-oncology...
November 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29147834/topical-collection-the-epds-thirty-years-on-special-guest-editor-john-cox-professor-emeritus-keele-university-uk-bm-bch-dm-oxon-frcpsyh-frcp-23-new-court-lnsdown-rd-cheltenham-gl50-2-jg
#20
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Archives of Women's Mental Health
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