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https://www.readbyqxmd.com/read/28449377/topical-antiviral-and-antifungal-medications-in-pregnancy-a-review-of-safety-profiles
#1
REVIEW
Viral M Patel, Robert A Schwartz, William C Lambert
Medications should be employed with caution in women of childbearing age who are pregnant or considering pregnancy. Compared to oral or parenteral agents, topical medications have limited systemic absorption and are deemed safer. However, their safety profile must be assessed cautiously due to the limited available data. In this article, we aggregate human and animal studies to provide recommendations on utilizing topical antiviral and antifungal medications in pregnancy. For antiviral medications, acyclovir and trichloroacetic acid are safe to use in pregnancy...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28449225/transfusion-research-priorities-for-blood-services-in-sub-saharan-africa
#2
REVIEW
Imelda Bates, Oliver Hassall, Tonderai Mapako
Evidence to support many blood transfusion policies and practices in sub-Saharan Africa (SSA) is weak or lacking. SSA cannot extrapolate from wealthy countries' research findings because its environment, users and structures are very different and SSA has critical blood shortages. SSA needs to generate its own evidence but research funds are very scarce and need to be carefully targeted to match need. This study aimed to define this need by determining research priorities for blood services in SSA. Thirty-five stakeholders representing diverse blood services' interests and expertise participated in a workshop...
April 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28449041/periodontal-disease-tooth-loss-and-cancer-risk
#3
Dominique S Michaud, Zhuxuan Fu, Jian Shi, Mei Chung
Periodontal disease, which includes gingivitis and periodontitis, is highly prevalent in adults and disease severity increases with age. The relationship between periodontal disease and oral cancer has been examined for several decades, but there is increasing interest in the link between periodontal disease and overall cancer risk, with systemic inflammation serving as the main focus for biological plausibility. Numerous case-control studies have addressed the role of oral health in head and neck cancer, and several cohort studies have examined associations with other types of cancers over the past decade...
April 25, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28448914/reconciling-agriculture-and-stream-restoration-in-europe-a-review-relating-to-the-eu-water-framework-directive
#4
REVIEW
H M Flávio, P Ferreira, N Formigo, J C Svendsen
Agriculture is widespread across the EU and has caused considerable impacts on freshwater ecosystems. To revert the degradation caused to streams and rivers, research and restoration efforts have been developed to recover ecosystem functions and services, with the European Water Framework Directive (WFD) playing a significant role in strengthening the progress. Analysing recent peer-reviewed European literature (2009-2016), this review explores 1) the conflicts and difficulties faced when restoring agriculturally impacted streams, 2) the aspects relevant to effectively reconcile agricultural land uses and healthy riverine ecosystems and 3) the effects and potential shortcomings of the first WFD management cycle...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448875/bioengineered-mannan-sulphate-capped-silver-nanoparticles-for-accelerated-and-targeted-wound-healing-physicochemical-and-biological-investigations
#5
Megha Mugade, Milind Patole, Varsha Pokharkar
In the present study, surface functionalized mannan sulphate silver nanoparticles (MS-AgNPs) were prepared and assessed for their wound healing potential. 20nm sized, spherical MS-AgNPs were prepared by one pot synthesis approach wherein the sulphated polysaccharide mannan sulphate (MS) played dual role of reducing as well as capping agent. The crystalline MS-AgNPs exhibited surface plasmon resonance centered at 400nm along with -32.40mV zeta potential. These stable MS-AgNPs showed enhanced cytocompatibility, targeting potential and cellular uptake in murine macrophages, human skin fibroblasts and human keratinocytes as compared to citrate reduced silver nanoparticles (C-AgNPs)...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448733/endogenous-meningococcal-endophthalmitis-with-isolated-joint-involvement-in-immunocompetent-adults
#6
Vishal Shah, Anurag Garg, Miles Stanford
PURPOSE: We report two cases of endogenous meningococcal endophthalmitis in immunocompetent adults presenting with unilateral ocular disease and joint involvement. METHODS: A retrospective review of two patients with endogenous endophthalmitis due to Neisseria meningitidis with associated arthropathy was conducted. The clinical presentation, investigations, treatment, and outcomes are presented. RESULTS: Vitreous sampling confirmed Neisseria meningitidis via polymerase chain reaction (PCR) in both cases...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448732/cytomegalovirus-anterior-uveitis-following-topical-cyclosporine-a
#7
Jay Siak, Soon-Phaik Chee
Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals and may manifest as Posner-Schlossman syndrome or Fuchs uveitis syndrome. The condition may first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, or the use of topical prostaglandin analogues for the treatment of glaucoma. We report the first case of a non-human immunodeficiency virus-infected individual who presented with CMV anterior uveitis after the use of topical cyclosporine A 0...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448635/excited-state-dynamics-of-bis-dehydroxycurcumin-tert-butyl-ester-a-diketo-shifted-derivative-of-the-photosensitizer-curcumin
#8
Luca Nardo, Angelo Maspero, Andrea Penoni, Giovanni Palmisano, Erika Ferrari, Monica Saladini
Bis-dehydroxycurcumin tert-butyl ester (K2T23) is a derivative of the natural spice curcumin. Curcumin is widely studied for its multiple therapeutic properties, including photosensitized cytotoxicity. However, the full exploitation of curcumin phototoxic potential is hindered by the extreme instability of its excited state, caused by very efficient non radiative decay by means of transfer of the enolic proton to the nearby keto oxygen. K2T23 is designed to exhibit a tautomeric equilibrium shifted toward the diketo conformers with respect to natural curcumin...
2017: PloS One
https://www.readbyqxmd.com/read/28448415/investigation-on-computed-tomography-features-of-primary-thymic-atypical-carcinoid-tumors
#9
Xiaojing Kan, Pengming Wang, Zhiquan Gong, Feifei Gao, Yuxia Zhang, Yinghui Ge
OBJECTIVES: The thymic atypical carcinoid tumors (aTCs) are rare. The computed tomography (CT) features of aTC were poorly studied, and researches under this topic with large samples are in a small quantity in the literature. Our aim was to investigate the CT features of aTC. METHODS: Eleven cases of aTC (7 men and 4 women; mean age, 56 ± 16 years) proved by pathology were retrospectively analyzed. All the patients underwent contrast-enhanced CT scans with dual phase (25-30 and 60-70 seconds) after contrast agent injection...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448359/rare-allergic-reaction-to-topical-chlorhexidine-gluconate
#10
Diane S Aschenbrenner
No abstract text is available yet for this article.
May 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28448238/single-dexamethasone-intravitreal-implant-in-the-treatment-of-noninfectious-uveitis
#11
Ariane Frère, Laure Caspers, Dorine Makhoul, Lia Judice, Laurence Postelmans, Xavier Janssens, Pierre Lefebvre, Christian Mélot, François Willermain
PURPOSE: To investigate the effect of a single intravitreal dexamethasone implant (IVT-DI; Ozurdex; Allergan, Inc.) on visual acuity, macular thickness, and intraocular pressure (IOP) in active noninfectious uveitis. METHODS: Medical records of patients with noninfectious active uveitis treated by IVT-DIs were retrospectively reviewed. Uveitis etiologies, treatment indications, best corrected visual acuity (BCVA), central retinal thickness measured by ocular coherence tomography, IOP, and systemic, local, and topical treatments were collected...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28448207/gender-differences-in-endovascular-treatment-of-infrainguinal-peripheral-artery-disease
#12
Henrik Christian Rieß, Eike Sebastian Debus, Franziska Heidemann, Konstanze Stoberock, Reinhart T Grundmann, Christian-Alexander Behrendt
BACKGROUND: Despite ongoing research concerning comorbidities and clinical presentation of peripheral arterial disease (PAD), the issue of gender associated differences in treatment is far from being settled. PATIENTS AND METHODS: This was a prospective, non-randomized multicentre study design. All patients suffering from intermittent claudication (IC) or critical limb ischaemia (CLI) were included. RESULTS: A total of 2,798 procedures for symptomatic PAD in the infrainguinal region were recorded, with 1,696 (61...
April 27, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28447992/intravital-microscopy-and-thrombus-induction-in-the-earlobe-of-a-hairless-mouse
#13
Daniel Strüder, Eberhard Grambow, Ernst Klar, Robert Mlynski, Brigitte Vollmar
Thrombotic complications of vascular diseases are one leading cause of morbidity and mortality in industrial nations. Due to the complex interactions between cellular and non-cellular blood components during thrombus formation, reliable studies of the physiology and pathophysiology of thrombosis can only be performed in vivo. Therefore, this article presents an ear model in hairless mice and focuses on the in vivo analysis of microcirculation, thrombus formation, and thrombus evolution. By using intravital fluorescence microscopy and the intravenous (iv) application of the respective fluorescent dyes, a repetitive analysis of microcirculation in the auricle can easily be performed, without the need for surgical preparation...
April 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447896/nanoemulsion-is-an-effective-antimicrobial-for-methicillin-resistant-staphylococcus-aureus-in-infected-wounds
#14
Zhengyi Cao, Theodore Spilker, Yongyi Fan, Linda M Kalikin, Susan Ciotti, John J LiPuma, Paul E Makidon, John Erby Wilkinson, James R Baker, Su He Wang
AIM: To develop NB-201, a nanoemulsion compound, as a novel microbicidal agent against methicillin-resistant Staphylococcus aureus (MRSA) infection, which is a common threat to public health but with limited therapeutic options. MATERIALS & METHODS: NB-201 was tested in in vitro and in vivo murine and porcine models infected with MRSA. RESULTS: Topical treatment of MRSA-infected wounds with NB-201 significantly decreased bacterial load and had no toxic effects on healthy skin tissues...
April 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28447886/drug-induced-hyperlactatemia
#15
Eike Blohm, Jeffrey Lai, Mark Neavyn
BACKGROUND: Hyperlactatemia is common in critically ill patients and has a variety of etiologies. Medication toxicity remains an uncommon cause that providers often fail to recognize. In this article, we review several medications that cause hyperlactatemia in either therapeutic or supratherapeutic dosing. When known, the incidence, mortality, pathophysiology, and treatment options are discussed. METHODS: We performed a literature search using PUBMED and Google Scholar for English language articles published after 1980 regarding medication induced hyperlactatemia and its management...
April 27, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28447880/resistance-training-in-youth-laying-the-foundation-for-injury-prevention-and-physical-literacy
#16
Christin Zwolski, Catherine Quatman-Yates, Mark V Paterno
CONTEXT: The rising incidence of physical activity- and sports-related injuries has prompted the present-day investigation of resistance training as a potential means of injury prevention and physical literacy development among youth. EVIDENCE ACQUISITION: Relevant studies on the topics of athlete development, physical literacy, resistance training, and injury prevention in children and adolescents were reviewed (PubMed and Sports Discus, 1982-2016). Recommendations from consensus guidelines and position statements applicable to resistance training and injury prevention in youth, in addition to young athlete development, were reviewed...
April 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28447832/the-role-of-political-affiliation-in-employment-decisions-a-model-and-research-agenda
#17
Philip L Roth, Caren B Goldberg, Jason B Thatcher
Organizational researchers have studied how individuals identify with groups and organizations and how this affiliation influences behavior for decades (e.g., Tajfel, 1982). Interestingly, investigation into political affiliation and political affiliation similarity in the organizational sciences is extremely rare. This is striking, given the deep political divides that exist between groups of individuals described in the political science literature. We draw from theories based on similarity, organizational identification, and person-environment fit, as well as theoretical notions related to individuating information, to develop a model, the political affiliation model (PAM), which describes the implications of political affiliation and political similarity for employment decisions...
April 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28447801/droplets-on-microdecorated-surfaces-evolution-of-the-polygonal-contact-line
#18
Alok Kumar, Rishi Raj
Interaction of liquids with surfaces is ubiquitous in our physical environment as well as many engineering applications. Recent advances on this topic have not only provided us with valuable insight into nature's design, but also enabled improved fluidic manipulation for liquid-based printing applications such as bio-microarrays for protein and DNA sequencing, multicolor polymer-based LED displays, inkjet printing, and solder droplet printing, among others. For example, droplet contact lines which are typically circular on a smooth and homogenous surface when deposited on a microdecorated surface may take various common polygonal shapes such as squares, rectangles, hexagons, octagons and dodecagons...
April 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28447799/enhanced-transdermal-delivery-by-combined-application-of-dissolving-microneedle-patch-on-serum-treated-skin
#19
Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Chengguo Li, Sang Gon Lee, Chang Hyun Kim, Young Wook Choi, So Jeong Kim, Ja Hyun Ryu, Ji Hwoon Baek, Jaesuk Koh, Hyungil Jung
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric micro-structure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, due to limited loading capacity of drugs within micro-sized structures, only small dosage can be delivered which are often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency...
April 27, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28447766/supervised-dosing-with-a-long-acting-opioid-medication-in-the-management-of-opioid-dependence
#20
REVIEW
Rosella Saulle, Simona Vecchi, Linda Gowing
BACKGROUND: Opioid dependence (OD) is an increasing clinical and public health problem worldwide. International guidelines recommend opioid substitution treatment (OST), such as methadone and buprenorphine, as first-line medication treatment for OD. A negative aspect of OST is that the medication used can be diverted both through sale on the black market, and the unsanctioned use of medications. Daily supervised administration of medications used in OST has the advantage of reducing the risk of diversion, and may promote therapeutic engagement, potentially enhancing the psychosocial aspect of OST, but costs more and is more restrictive on the client than dispensing for off-site consumption...
April 27, 2017: Cochrane Database of Systematic Reviews
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