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https://www.readbyqxmd.com/read/28719895/update-on-the-pathophysiology-and-risk-factors-for-the-development-of-malignant-testicular-germ-cell-tumors-in-complete-androgen-insensitivity-syndrome
#1
Martine Cools, Leendert Looijenga
Prophylactic gonadectomy in young adult women with complete androgen insensitivity syndrome (CAIS) to avoid development of an invasive testicular germ cell tumor (TGCT) is currently advised in most centers. However, women with CAIS increasingly question the need of this procedure. In order to provide optimal counseling and follow-up of these women, insight in the mechanisms underlying TGCT development in androgen insensitivity syndrome (AIS), data regarding the incidence of TGCT in AIS adults specifically, and an overview of existing and novel screening tools for in situ and invasive neoplastic lesions are crucial...
July 19, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28719812/the-impact-of-zno-and-tio2-on-the-stability-of-clotrimazole-under-uva-irradiation-identification-of-photocatalytic-degradation-products-and-in-vitro-cytotoxicity-assessment
#2
Agata Kryczyk, Paweł Żmudzki, Paulina Koczurkiewicz, Joanna Piotrowska, Elżbieta Pękala, Urszula Hubicka
In order to ensure the safe and effective use of pharmaceutical products especially for topical administration photostability testing is necessary. The current paper presents an in-depth analysis of the stability of one of the most common antifungal agents, namely clotrimazole. Clotrimazole has proven to be stable under UVA irradiation in applied experimental conditions, but the presence of catalysts such as ZnO and TiO2 has contributed significantly to the degradation of this compound. The findings indicate that its photocatalytic degradation reactions followed the pseudo first-order kinetics with rate constant depending on the pH and the used solvent...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28719651/link-prediction-on-twitter
#3
Sanda Martinčić-Ipšić, Edvin Močibob, Matjaž Perc
With over 300 million active users, Twitter is among the largest online news and social networking services in existence today. Open access to information on Twitter makes it a valuable source of data for research on social interactions, sentiment analysis, content diffusion, link prediction, and the dynamics behind human collective behaviour in general. Here we use Twitter data to construct co-occurrence language networks based on hashtags and based on all the words in tweets, and we use these networks to study link prediction by means of different methods and evaluation metrics...
2017: PloS One
https://www.readbyqxmd.com/read/28719593/long-term-treatment-of-eosinophilic-esophagitis-with-swallowed-topical-corticosteroids-development-and-evaluation-of-a-therapeutic-concept
#4
Thomas Greuter, Christian Bussmann, Ekaterina Safroneeva, Alain M Schoepfer, Luc Biedermann, Stephan R Vavricka, Alex Straumann
OBJECTIVES: Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting remission can be achieved, and whether treatment can be stopped once patients have achieved this remission. METHODS: Since 2007, EoE patients included into a large database at the Swiss EoE Clinics were put on STCs as induction/maintenance therapy...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719512/a-pediatric-case-of-persistent-thrombocytopenia-in-a-patient-who-developed-all
#5
Haroon Shaukat, Jessica O'Mara, Michelle Neier
Inherited thrombocytopenia is a topic that was expanded greatly over the last decade and many new genes are being identified. However, inheritance patterns are not always easy to identify because sporadic cases from de novo mutations may in fact be more common. Few studies have assessed the relationship between thrombocytopenia and malignancies, specifically acute lymphoblastic leukemia (ALL). Here we present a pediatric case of persistent thrombocytopenia associated with T-cell ALL. Our patient was initially diagnosed with immune thrombocytopenic purpura with no evidence of malignancy on bone marrow biopsy but presented shortly after with ALL...
July 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28719485/does-the-application-of-heat-gel-pack-after-eutectic-mixture-of-local-anesthetic-cream-improve-venipuncture-or-intravenous-cannulation-success-rate-in-children-a-randomized-control-trial
#6
Silvana Schreiber, Giorgio Cozzi, Giuseppa Patti, Andrea Taddio, Marcella Montico, Chiara Pierobon, Egidio Barbi
OBJECTIVE: Needle-related procedures are the most common sources of pain for children in the hospital setting. The most used topical anesthetic, eutectic mixture of local anesthetic (EMLA) cream, may cause transient vasoconstriction. It has been postulated that this vasoconstriction may decrease vein visualization. The application of heat gel pack after removal of EMLA cream in the site of venipuncture counteracts the vasoconstriction, improving vein visualization. We assessed using a prospective randomized controlled trial whether the application of heat gel pack increases the needle procedure success rate...
July 17, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28719473/delayed-patch-test-reading-after-5-days-an-update-from-the-mayo-clinic-contact-dermatitis-group
#7
Hafsa M Chaudhry, Lisa A Drage, Rokea A El-Azhary, Matthew R Hall, Jill M Killian, Amy V Prakash, James A Yiannias, Mark D P Davis
BACKGROUND: Patch-test readings after day 5 have previously been used to identify delayed reactions to metals and topical antibiotics. OBJECTIVE: The aims of this study were to identify allergens for which late readings (beyond day 5) would be most valuable and to compare our results with our previous study on delayed patch-test readings. METHODS: This was a retrospective study of 298 patients who underwent metal and corticosteroid series patch testing from January 1, 2007, through December 31, 2013...
July 2017: Dermatitis
https://www.readbyqxmd.com/read/28719394/cochlear-implantation-in-children-under-12-months-of-age
#8
Samantha McKinney
PURPOSE OF REVIEW: Children with congenital hearing loss are being identified earlier, leading to earlier intervention. Current US Food and Drug Administration (FDA) criteria states a child must be 12 months or older for cochlear implantation. The purpose of this article is to review recent publications regarding the benefits of implanting infants under 12 months of age. Topics include: safety and efficacy of surgery, speech and language acquisition outcomes, audiologic components, and limitations...
July 14, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28719393/restrictions-and-limitations-after-pelvic-floor-surgery-what-s-the-evidence
#9
Miles Murphy
PURPOSE OF REVIEW: A common concern regarding pelvic floor surgery is the relatively high risk of recurrence. In an effort to minimize this risk, many surgeons instruct their patients to avoid certain activities during the healing process so as not to damage the repair before proper healing has occurred. However, many of these restrictions have been historically based on little to no hard evidence. The purpose of this review is to present the latest evidence-based recommendations regarding restrictions and limitations after pelvic floor surgery...
July 17, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28719372/basics-of-compounding-3d-printing-pharmacy-applications-part-3-compounding-formulation-considerations-and-the-future
#10
Loyd V Allen
3D printing is a standard tool in the automotive, aerospace, and consumer goods in industry and is gaining traction in pharmaceutical manufacturing, which has introduced a new element into dosage form development. This article, which represents part 3 of a 3-part article on the topic of 3D printing, discusses the compounding, formulation considerations, and the future of 3D printing.
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719370/simple-preparation-of-timolol-0-5-gel-from-eye-drop-solution-for-superficial-infantile-hemangiomas
#11
Winnie Choo
The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Topical application of timolol eye drop has been mentioned in few studies, most of which reported that the solution cannot stay on the site of application due to its fluidity...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719247/telehealth-in-schools-using-a-systematic-educational-model-based-on-fiction-screenplays-interactive-documentaries-and-three-dimensional-computer-graphics
#12
Diogo Julien Miranda, Chao Lung Wen
BACKGROUND: Preliminary studies suggest the need of a global vision in academic reform, leading to education re-invention. This would include problem-based education using transversal topics, developing of thinking skills, social interaction, and information-processing skills. We aimed to develop a new educational model in health with modular components to be broadcast and applied as a tele-education course. MATERIALS AND METHODS: We developed a systematic model based on a "Skills and Goals Matrix" to adapt scientific contents on fictional screenplays, three-dimensional (3D) computer graphics of the human body, and interactive documentaries...
July 18, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28719234/the-in-vivo-effects-of-the-cb1-positive-allosteric-modulator-gat229-on-intraocular-pressure-in-ocular-normotensive-and-hypertensive-mice
#13
Elizabeth A Cairns, Anna-Maria Szczesniak, Alex J Straiker, Pushkar M Kulkarni, Roger G Pertwee, Ganesh A Thakur, William H Baldridge, Melanie E M Kelly
PURPOSE: Orthosteric cannabinoid receptor 1 (CB1) activation leads to decreases in intraocular pressure (IOP). However, use of orthosteric CB1 agonists chronically has several disadvantages, limiting their usefulness as clinically relevant drugs. Allosteric modulators interact with topographically distinct sites to orthosteric ligands and may be useful to circumvent some of these disadvantages. The purpose of this study was to investigate the effects of the novel CB1-positive allosteric modulator (PAM) GAT229 on IOP...
July 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28719177/classics-in-neuroimaging-imaging-the-dopaminergic-pathway-with-pet
#14
Meghna Kanthan, Paul Cumming, Jacob M Hooker, Neil Vasdev
The success of positron emission tomography (PET) for observing molecular processes underlying brain function and disease is underpinned by radiotracer chemistry. From the earliest applications of PET to measure dopamine synthesis capacity and the abundance of neuroreceptors and transporters, to the more recent topic of dynamic neurochemical imaging, interrogation of brain dopamine in conditions such as neurodegenerative diseases, schizophrenia, mood disorders, and addictions has been a driving force that challenges the ingenuity of radiopharmaceutical scientists...
July 18, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28719090/learning-new-avenues-and-new-topics
#15
EDITORIAL
Alan J Card
No abstract text is available yet for this article.
July 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28719041/prevention-of-post-ercp-pancreatitis-is-more-than-just-suppositories-and-stents
#16
EDITORIAL
C Mel Wilcox
In this issue of the Journal, Professor Elmunzer provides an outstanding overview of the variable methods of prevention of post-ERCP pancreatitis (PEP) (1). We all recognize the importance of this topic given its morbidity for our patients. His review succinctly summarizes a wealth of both old and new data underscoring previously identified risk factors for PEP which have stood the test of time. In addition, newer interventions are appraised and placed in an appropriate context. This article is protected by copyright...
July 18, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28718933/treatment-of-hidradenitis-suppurativa-with-rifampicin-have-we-forgotten-tuberculosis
#17
P Mendes-Bastos, R Macedo, R Duarte
Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C)...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718886/brainstem-auditory-evoked-responses-in-37-dogs-with-otitis-media-before-and-after-topical-therapy
#18
S Paterson
OBJECTIVES: The objective of this study was to determine whether intra-aural administration of aqueous solutions of marbofloxacin, gentamicin, tobramycin and ticarcillin (used off-licence) was associated with changes in hearing as measured by brainstem auditory evoked responses. MATERIALS AND METHODS: Dogs diagnosed with otitis media (n=37) underwent brainstem auditory evoked response testing and then were treated for their ear disease. First, the external ear canal and middle ear were flushed with sterile saline followed by EDTA tris with 0·15% chlorhexidine...
July 18, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28718817/time-to-spread-your-wings-a-review-of-the-avian-ancient-dna-field
#19
REVIEW
Alicia Grealy, Nicolas J Rawlence, Michael Bunce
Ancient DNA (aDNA) has the ability to inform the evolutionary history of both extant and extinct taxa; however, the use of aDNA in the study of avian evolution is lacking in comparison to other vertebrates, despite birds being one of the most species-rich vertebrate classes. Here, we review the field of "avian ancient DNA" by summarising the past three decades of literature on this topic. Most studies over this time have used avian aDNA to reconstruct phylogenetic relationships and clarify taxonomy based on the sequencing of a few mitochondrial loci, but recent studies are moving toward using a comparative genomics approach to address developmental and functional questions...
July 18, 2017: Genes
https://www.readbyqxmd.com/read/28718653/vertical-versus-lateral-two-dimensional-heterostructures-on-the-topic-of-atomically-abrupt-p-n-junctions
#20
Ruiping Zhou, Vaibhav Ostwal, Joerg Appenzeller
The key appeal of two-dimensional (2D) materials such as graphene, transition metal dichalcogenides (TMDs), or phosphorene for electronic applications certainly lies in their atomically thin nature that offers opportunities for devices beyond conventional transistors. It is also this property that makes them naturally suited for a type of integration that is not possible with any three-dimensional (3D) material, that is, forming heterostructures by stacking dissimilar 2D materials together. Recently, a number of research groups have reported on the formation of atomically sharp p/n-junctions in various 2D heterostructures that show strong diode-type rectification...
July 18, 2017: Nano Letters
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