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https://www.readbyqxmd.com/read/29666415/canonical-pi3k%C3%AE-signaling-in-myeloid-cells-restricts-trypanosoma-cruzi-infection-and-dampens-chagasic-myocarditis
#1
Maria C Silva, Marcela Davoli-Ferreira, Tiago S Medina, Renata Sesti-Costa, Grace K Silva, Carla D Lopes, Lucas E Cardozo, Fábio N Gava, Konstantina Lyroni, Fabrício C Dias, Amanda F Frade, Monique Baron, Helder I Nakaya, Florêncio Figueiredo, José C Alves-Filho, Fernando Q Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S Silva, Thiago M Cunha
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. Here, we show that the canonical PI3Kγ pathway is upregulated in both human chagasic hearts and hearts of acutely infected mice. PI3Kγ-deficient mice and mutant mice carrying catalytically inactive PI3Kγ are more susceptible to T. cruzi infection. The canonical PI3Kγ signaling in myeloid cells is essential to restrict T...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29665402/n-acetylcysteine-inhibits-mancozeb-induced-impairments-to-the-normal-development-of-zebrafish-embryos
#2
Dennis Guilherme Costa-Silva, Luana Paganotto Leandro, Pratícia Brum Vieira, Nelson Rodrigues de Carvalho, Andressa Rubim Lopes, Lucia Emanueli Schimith, Mauro Eugênio Medina Nunes, Renata Siqueira de Mello, Illana Kemmerich Martins, Adriano Alves de Paula, Andrés Delgado Cañedo, José Cláudio Fonseca Moreira, Thais Posser, Jeferson Luis Franco
Mancozeb (MZ), a manganese/zinc-containing ethylene-bis-dithiocarbamate (EBCD) fungicide has been claimed to present low acute toxicity and short environmental persistence, however, its effects on embryogenesis in non-target organisms is unclear. Here, we used zebrafish embryos (5 hpf) to assess the potential embryotoxic effects induced by MZ (up to 72 hpf) as well as the role of reactive oxygen species (ROS) in this process by pre-treatment with a classical antioxidant (N-acetylcysteine, NAC). Markers of reactive oxygen species production (ROS), glutathione (GSH) levels and glutathione S-transferase (GST) activity were measured along with genotoxicity (comet assay), cell death (Acridine Orange) and behavioral parameters (spontaneous movement, touch stimulation and swimming response), in order to determine potential mechanisms of embryotoxicity...
April 14, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29665227/microenvironment-induced-pim-kinases-promote-cxcr4-triggered-mtor-pathway-required-for-chronic-lymphocytic-leukaemia-cell-migration
#3
Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska-Kania, Bartosz Puła, Hanna Makuch-Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech-Marańda, Bożena K Budziszewska, Maja Wasylecka-Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka, Przemysław Juszczyński
Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimulation, and coculture with stromal cells increases PIMs expression in CLL cells, indicating microenvironment-dependent PIMs regulation. PIM1 and PIM2 expression at diagnosis was higher in patients with advanced disease (Binet C vs...
April 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29665125/cross-sectional-study-showed-that-breakfast-consumption-was-associated-with-demographic-clinical-and-biochemical-factors-in-children-and-adolescents
#4
Fabiana A Silva, Cristina Padez, Daniela S Sartorelli, Renata M S Oliveira, Michele P Netto, Larissa L Mendes, Ana Paula C Cândido
AIM: We investigated the demographic, anthropometric, clinical, biochemical and behavioural factors associated with children and adolescents who missed breakfast. METHODS: This 2012 cross-sectional study was carried out in the city of Juiz de Fora, Brazil, with a sample of 684 students: 191 children aged 7-9 and 493 adolescents aged 10-14. Data on demographic, physical activity and breakfast consumption was based on a 24-hour recall record and a three-day dietary record...
April 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29664872/team-approach-the-management-of-infection-after-total-knee-replacement
#5
Chun Hoi Yan, Carla Renata Arciola, Alex Soriano, L Scott Levin, Thomas W Bauer, Javad Parvizi
No abstract text is available yet for this article.
April 17, 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29663875/heterocyclic-n-oxides-a-promising-class-of-agents-against-tuberculosis-malaria-and-neglected-tropical-diseases
#6
Guilherme Felipe Dos Santos Fernandes, Aline Renata Pavan, Jean Leandro Dos Santos
Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxide are described herein, nevertheless, the following chemical classes deserve to be highlighted due to the large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide...
April 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29663167/structural-studies-on-radiopharmaceutical-dota-minigastrin-analogue-cp04-complexes-and-their-interaction-with-cck2-receptor
#7
Piotr F J Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz Dobrowolski, Marta K Dudek, Monika Orzełowska, Renata Mikołajczak
BACKGROUND: The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carcinoma (MTC)), thus matching with a theranostic principle. Several peptide conjugates suitable for the TRNT of MTC have been synthesized, including a very promising minigastrin analogue DOTA-(DGlu)6 -Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (CP04). In this contribution, we wanted to see whether CP04 binding affinity for CCK-2R is sensitive to the type of the complexed radiometal, as well as to get insights into the structure of CP04-CCK2R complex by molecular modeling...
April 16, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29662895/heme-oxygenase-1-activity-as-a-correlate-to-exercise-mediated-amelioration-of-cognitive-decline-and-neuropathological-alterations-in-an-aging-rat-model-of-dementia
#8
Andrea Kurucz, Mariann Bombicz, Rita Kiss, Dániel Priksz, Balázs Varga, Tibor Hortobágyi, György Trencsényi, Renáta Szabó, Anikó Pósa, Rudolf Gesztelyi, Zoltán Szilvássy, Béla Juhász
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)-an important cellular cytoprotectant in preserving mental acuity-using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups-namely, (i) aged sedentary (control) females (ASF, n = 8); (ii) aged sedentary (control) males (ASM, n = 8); (iii) aged running females (ARF, n = 8); (iv) aged running males (ARM, n = 8); (v) young control females (YCF, n = 8); and (vi) young control males (YCM, n = 8)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29662531/cystic-brain-metastases-in-alk-rearranged-non-small-cell-lung-cancer
#9
REVIEW
Guilherme Nader Marta, Renata Rodrigues da Cunha Colombo Bonadio, Renata Eiras Martins, Henrique Bortot Zuppani, Gilberto de Castro
The central nervous system (CNS) is a common site of disease progression in patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearrangement treated with crizotinib. Cystic brain metastases (CBM) have been recently identified as one possible variant of this disease. An illustrative case report is presented along with a literature review performed in order to track relevant papers about CBM in ALK-rearranged NSCLC, including possible pathophysiology, differential diagnosis and treatment options for this condition...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29660689/quinonoid-compounds-via-reactions-of-lawsone-and-2-aminonaphthoquinone-with-%C3%AE-bromonitroalkenes-and-nitroallylic-acetates-structural-diversity-by-c-ring-modification-and-cytotoxic-evaluation-against-cancer-cells
#10
Thekke V Baiju, Renata G Almeida, Sudheesh T Sivanandan, Carlos A de Simone, Lucas M Brito, Bruno C Cavalcanti, Claudia Pessoa, Irishi N N Namboothiri, Eufrânio N da Silva Júnior
Morita-Baylis-Hillman acetates and α-bromonitroalkenes have been employed in cascade reactions with lawsone and 2-aminonaphthoquinone for the one-pot synthesis of heterocycle fused quinonoid compounds. The reactions reported here utilized the 1,3-binucleophilic potential of hydroxy- and aminonaphthoquinones and the 1,2/1,3-bielectrophilic potential of bromonitroalkenes and Morita-Baylis-Hillman acetates for the synthesis of pyrrole and furan fused naphthoquinones. The synthesized compounds were evaluated against HCT-116 (human colon carcinoma cells), PC3 (human prostate cancer cells), HL-60 (human promyelocytic leukemia cells), SF295 (human glioblastoma cells) and NCI-H460 (human lung cancer cells) and exhibited antitumor activity with IC50 values as low as < 2 μM...
April 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29660627/positive-effect-of-resveratrol-against-preantral-follicles-degeneration-after-ovarian-tissue-vitrification
#11
Carina Diniz Rocha, Mayara Mafra Soares, Deize de Cássia Antonino, Jairo Melo Júnior, Renata Ferreira Freitas Mohallem, Ana Paula Ribeiro Rodrigues, José Ricardo Figueiredo, Marcelo Emílio Beletti, José Octavio Jacomini, Benner Geraldo Alves, Kele Amaral Alves
This study aimed to evaluate whether the addition of resveratrol to vitrification/thawing medium improves the cryotolerance of preantral follicles enclosed in bovine ovarian fragments. Ovarian fragments were obtained from bovine fetuses and distributed to the following groups: fresh ovarian fragments (control), vitrified (VIT), and vitrified with resveratrol (VIT + RESV). Overall, the mean percentage of normal follicles was greater (P < 0.05) in the VIT + RESV compared to the VIT group. Moreover, the probability of finding normal follicles was 2...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29660457/a-lectin-fraction-from-green-seaweed-caulerpa-cupressoides-inhibits-inflammatory-nociception-in-the-temporomandibular-joint-of-rats-dependent-from-peripheral-mechanisms
#12
Renata Line da Conceição Rivanor, Danielle Rocha Do Val, Natássia Albuquerque Ribeiro, Felipe Dantas Silveira, Ellen Lima de Assis, Álvaro Xavier Franco, Lorena Vasconcelos Vieira, Ismael Nilo Lino de Queiroz, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra, Norma Maria Barros Benevides
Temporomandibular disorders are the second most common cause of orofacial pain mediated by inflammatory compounds, which in many cases leads to chronic orofacial pain. This study assessed the antinociceptive and anti-inflammatory effects of a lectin from the green seaweed Caulerpa cupressoides (CcL) on hypernociception inflammatory in TMJ of rats and investigated the involvement of different mechanisms. Rats received i.v. CcL 30 min prior to injection of flogistic agentes or 0.9% saline into the left TMJ...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29659962/low-dietary-folate-interacts-with-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-to-increase-incidence-of-developmental-delays-and-defects
#13
Karen E Christensen, Renata H Bahous, Wenyang Hou, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with increased birth defect risk, likely through reduced purine synthesis. Objective: We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658968/comet-and-cytogenetic-tests-as-tools-for-evaluating-genomic-instability-in-seeds-of-oryza-sativa-l-and-phaseolus-vulgaris-l-from-gene-banks
#14
Alisson F Dantas, Renata M Lopes, Maria L Fascineli, Solange C B R José, Juliano G Pádua, Marcos A Gimenes, Cesar K Grisolia
This study aimed to assess the feasibility of comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. (rice) and Phaseolus vulgaris (beans) L. from gene banks. Rice and beans were exposed to methyl methanesulfonate (MMS) as a reference DNA damaging agent. Seeds of two accessions of rice and beans were obtained from Embrapa Rice and Beans - Brazil. Seed groups were imbibed in three concentrations of MMS for three periods of time to carry out cytogenetic tests, and for one period for the comet test...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29658799/the-validity-and-reliability-of-the-adl-glittre-test-for-children
#15
Renata Martins, Maíra S de Assumpção, Tatiana G Bobbio, Anamaria F Mayer, Camila Schivinski
OBJECTIVE: The ADL-Glittre was created to assess more comprehensively the essential activities of daily living in adults with chronic obstructive pulmonary disease. The aim of this study was to validate the ADL-Glittre test adapted for children (TGlittre-P) and verify its reliability. METHODS: This is a cross-sectional study with 87 healthy children aged 6 to 14 years (mean 10.36 ± 2.32 years). Biometric and spirometry data were collected from all participants...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29657143/clinical-and-serological-associations-with-the-development-of-incident-proteinuria-in-danish-patients-with-systemic-lupus-erythematosus
#16
Nima Tanha, Renata Baronaite Hansen, Christoffer Tandrup Nielsen, Mikkel Faurschou, Søren Jacobsen
OBJECTIVE: In a longitudinal cohort study, we investigated whether clinical and serological manifestations at the time of classification of systemic lupus erythematosus (SLE) were predictive of subsequent development of incident proteinuria as a biomarker of incident lupus nephritis. METHODS: Patients fulfilling SLE classification criteria but having no proteinuria prior to or at the time of classification were included. Data on SLE manifestations, vital status, criteria-related autoantibodies, and SLE-associated medications were collected during clinical visits and supplemented by chart review...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656679/three-dimensional-reconstruction-of-fetal-abnormalities-using-ultrasonography-and-magnetic-resonance-imaging
#17
Heron Werner, Maene Marcondes, Pedro Daltro, Tatiana Fazecas, Bianca Guedes Ribeiro, Renata Nogueira, Edward Araujo Júnior
OBJECTIVE: We aimed to compare three-dimensional (3D) fetal malformation images obtained using ultrasonography (US) and magnetic resonance imaging (MRI) on the same day during the third trimester of pregnancy. METHODS: Total 33 fetuses were selected from cases evaluated for malformations. Morphological abnormalities were first scanned using 3DUS . MRI was used to confirm the previous preliminary 3DUS findings, and diagnoses were confirmed postnatally. 3DUS scans were performed transabdominally using an Rab (4-8 L) probe, Voluson 730 Pro/Expert and E8 (General Electric, Healthcare, Zipf, Austria)...
April 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29655517/integrating-pregnancy-prevention-into-an-hiv-counseling-and-testing-program-in-pediatric-primary-care
#18
Noah J Wheeler, Krishna K Upadhya, Marie-Sophie Tawe, Kathy Tomaszewski, Renata Arrington-Sanders, Arik V Marcell
PURPOSE: Certified health educator (CHE)-based HIV counseling and testing typically focus on HIV and sexually transmitted infection (STI) prevention only. A quality improvement initiative examined integrating assessment of reproductive life plans, counseling about pregnancy prevention, and contraception referral into a CHE-based HIV testing program. METHODS: Between February 2014 and January 2017, in one urban pediatric primary care clinic serving patients aged 0-25, CHEs assessed sexual history, HIV risk, short-term (i...
April 11, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29652533/facial-and-nasolabial-aesthetics-of-complete-uclp-submitted-to-2-stage-palate-repair-with-vomer-flap
#19
Terumi Okada Ozawa, Luciana Lais Savero Reis, Renata Mayumi Kato, Diógenes Laercio Rocha, Renata Sathler, Daniela Gamba Garib
OBJECTIVE: To evaluate the aesthetics of nasolabial appearance and facial profile of children with unilateral cleft lip and palate (UCLP) submitted to 2-stage palate repair with vomerine flap. DESIGN: Retrospective. SETTING: Single center. PATIENTS: Forty patients with UCLP, mean age of 7.81 years of both sexes, rehabilitated at a single center by 1 plastic surgeon. INTERVENTIONS: Lip and anterior palate repair with nasal alar repositioning was performed at 3 to 6 months of age by Millard technique and vomer flap, respectively...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29651544/the-effects-of-sediment-classification-pattern-on-a-water-column-organism-ceriodaphnia-dubia
#20
Vivian Silva Lira, Cláudia Hitomi Watanabe, Marcela Merides Carvalho, André Henrique Rosa, Renata Fracácio
The sediment compartment stands out because it functions as both a temporary sink of pollutants and a potential source of these elements that may become available to the water column.This study aimed to correlate the concentrations of total metals in the crude sediment and in the interstitial water with the ecotoxicity in the water column using an a modified sediment ecotoxicity test with Ceriodaphnia dubia. The results indicate that the sediment may contribute to the toxicity in the water column and that such toxicity is possibly not related to the metals present...
April 12, 2018: Bulletin of Environmental Contamination and Toxicology
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