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Fetal hydrothorax

Ruben S G M Witlox, Frans J C M Klumper, Arjan B Te Pas, Erik W van Zwet, Dick Oepkes, Enrico Lopriore
AIM: To evaluate the short-term neonatal outcome after fetal thoracoamniotic shunt placement for isolated hydrothorax. METHODS: Retrospective evaluation of infants with isolated hydrothorax treated with thoracoamniotic shunt placement at our fetal therapy centre between 2001 and 2016. RESULTS: In total 48 fetuses were treated with a thoracoamniotic shunt. All fetuses had signs of hydrops at the time of intervention. Median (IQR) gestational age at shunting was 28...
August 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
Yasuo Yumoto, Seung Chik Jwa, Seiji Wada, Yuichiro Takahashi, Keisuke Ishii, Kiyoko Kato, Noriaki Usui, Haruhiko Sago
OBJECTIVES: To determine the characteristics, outcomes, and prognostic factors of fetal hydrothorax (FHT) with trisomy 21. METHODS: A nationwide survey was conducted on FHT fetuses with trisomy 21 delivered after 22 weeks' gestation between January 2007 and December 2011 at perinatal centers. RESULTS: The 91 cases of FHT with trisomy 21 included 28 (30.8%) diagnosed in utero and 63 (69.2%) diagnosed after birth. The natural remission rate was 6...
May 11, 2017: Prenatal Diagnosis
Michelle Han, Yalda Afshar, Andrew H Chon, Emily Scibetta, Rashmi Rao, Ramen H Chmait
INTRODUCTION: Pseudoamniotic band syndrome (PABS) occurs iatrogenically after fetal surgery or amniocentesis due to chorioamniotic membrane separation. Separation of the amnion from the chorion can expand to form fibrous amniotic bands that can envelope fetal limbs or the umbilical cord, with consequences ranging from limb constriction to fetal demise. CASE REPORT: We report a case of bilateral fetal pleural effusions at 27 weeks' gestation treated by bilateral thoracoamniotic shunts...
April 28, 2017: Fetal and Pediatric Pathology
Seiji Wada, Seung Chik Jwa, Yasuo Yumoto, Yuichiro Takahashi, Keisuke Ishii, Noriaki Usui, Haruhiko Sago
OBJECTIVES: This study aims to determine the prognostic factors and outcomes of primary fetal hydrothorax (FHT) and investigate the effects of fetal therapy. METHODS: A nationwide survey was conducted on fetuses with primary FHT delivered after 22 weeks of gestation between January 2007 and December 2011 at perinatal centers. RESULTS: Among the 287 cases of primary FHT, the survival rates for those with and without hydrops were 58.0% (113/195) and 97...
February 2017: Prenatal Diagnosis
F Suyama, K Ozawa, R Sugibayashi, S Wada, H Sago
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
H Sago, Y Yumoto, S Jwa, S Wada, Y Takahashi, K Ishii, N Usui
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Michael R Mallmann, Viola Graham, Bettina Rösing, Ingo Gottschalk, Andreas Müller, Ulrich Gembruch, Annegret Geipel, Christoph Berg
OBJECTIVE: To assess predictors for survival and complications among a relatively large cohort of fetuses with hydrothorax treated by thoracoamniotic shunting. METHODS: All cases with hydrothorax treated by thoracoamniotic shunting in a 10-year period (2002-2011) in two centers were retrospectively reviewed. RESULTS: A total of 78 fetuses with hydrothorax treated with thoracoamniotic shunting were included in the study. Mean gestational age at diagnosis was 25...
2017: Fetal Diagnosis and Therapy
Manoel Sarno, Gielson A Sacramento, Ricardo Khouri, Mateus S do Rosário, Federico Costa, Gracinda Archanjo, Luciane A Santos, Nivison Nery, Nikos Vasilakis, Albert I Ko, Antonio R P de Almeida
BACKGROUND: The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS: We report a case of a 20-year-old pregnant woman who was referred to our service after a large Zika virus outbreak in the city of Salvador, Brazil with an ultrasound examination that showed intrauterine growth retardation of the fetus at the 18th gestational week...
February 2016: PLoS Neglected Tropical Diseases
Zhitao Zhang, Shanshan Zhang, Shaowei Yin, Shanshan Liao, Caixia Liu
OBJECTIVE: To research the important of prenatal diagnosis and effect of intervention to fetal hydrothorax. METHODS: The cases of fetal hydrothorax (n=5) were obtained from the Shengjing Hospital, China Medical University between December 2014 and May 2015. All pregnancies were uncomplicated, excluded congenital organic and chromosomal abnormalities during prenatal diagnosis and with a 37 average gestational weeks. The case 1, 2, 4 were unilateral hydrothorax and the case 3, 5 were bilateral...
January 2016: Zhonghua Fu Chan Ke za Zhi
Luz Juárez-García, Miguel de Jesús Lopez Rioja, María Teresa Leis-Márquez, Alfredo Machuca-Vaca, Julio Erdmenger-Orellana
The use of prenatal ultrasonography has improve the detection of fetal abnormalities, which affects the perception about the natural history and evolution of them, changing the management of the fetus and neonate. Today, it is possible to perform an early prenatal diagnosis, and be treated even intrauterine with high rates of success. Such is the case of Congenital Cystic Adenomatoid Malformation (CCAM), characterized by abnormal proliferation and dilatation of the terminal structures of the airway, generating multiple cysts of diferent sizes and locations...
May 2015: Ginecología y Obstetricia de México
Bernhard Stoiber, Ueli Moehrlen, Jouzas Kurmanavicius, Martin Meuli, Christian Haslinger, Roland Zimmermann, Nicole Ochsenbein
Purpose To describe the prenatal course and perinatal outcome, and to define prognostic markers for fetuses with congenital pulmonary airway malformation (CPAM) or bronchopulmonary sequestration (BPS). Materials and Methods A retrospective study was performed at the University Hospital Zurich including pregnancies with either fetal CPAM (n = 26) or BPS (n = 11) between 2000 and 2013. Results Three patients decided for termination of pregnancy. Two intrauterine deaths (CPAM) occurred at 25 weeks...
April 2017: Ultraschall in der Medizin
Yingnan Wang, Yiqun Gu, Xiaobo Zhang, Aichun Wang, Junling Xie, Lijuan Lu, Yunfei Sun
OBJECTIVE: To study the etiology, pathogenesis, clinicopathologic characteristics, prognosis and treatment of congenital pulmonary airway malformation (CPAM). METHODS: Eighteen cases of CPAM were enrolled into the study. The clinical history, autopsy findings and immunohistochemical results were evaluated, with review of literature. The pathogenetic mechanism, pathologic features and differential diagnosis of CPAM were studied. RESULTS: Histologic examination showed that 2 cases were classified as Stocker type I, 12 cases as type II, and 4 cases as type III...
April 2015: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Brooke O'Brien, Greg Kesby, Robert Ogle, Ingrid Rieger, Jon A Hyett
BACKGROUND: Primary fetal hydrothorax (PFHT) is an uncommon condition with an estimated prevalence of 1 in 10,000/15,000 pregnancies. Therapeutic interventions include thoracocentesis, thoraco-amniotic shunting (TAS), and pleurodesis using OK-432. METHODS: A review of the literature was performed to identify all cases of PFHT treated with TAS and OK-432. All cases of PFHT referred to the Fetal Maternal Unit at Royal Prince Alfred Hospital between 2002 and 2012 were retrospectively reviewed...
2015: Fetal Diagnosis and Therapy
Alan M Coleman, Arnold C Merrow, Timothy M Crombleholme, Ronald Jaekle, Foong-Yen Lim
While bronchopulmonary sequestration typically has a benign course, this congenital lung malformation has a high mortality rate when associated with untreated in utero tension hydrothorax and hydrops. Hydrops related to bronchopulmonary sequestration is believed to result from torsion of the mass with compromise of the associated blood supply. The impaired venous return of the mass then leads to tension hydrothorax with compression of the heart and mediastinal vessels, impairing global venous return. To our knowledge, this scenario has only been described prenatally by ultrasound...
2016: Fetal Diagnosis and Therapy
Dominique Mannaerts, Joke Muys, Paul Ramaekers, Yves Jacquemyn
We report a case of bilateral fetal hydrothorax presenting at 20 weeks of pregnancy, spontaneously resolving at 22 weeks and severely relapsing at 28 weeks in a fetus with normal karyotype. The cause was a high-output heart failure caused by vein of Galen malformation.
January 27, 2015: BMJ Case Reports
Luzie Bülow, Christina Lissewski, Rainer Bressel, Anita Rauch, Zornitza Stark, Martin Zenker, Oliver Bartsch
Fetal hydrops, fetal pleural effusions, hydrothorax, and chylothorax, may be associated with various genetic disorders, in particular with the Noonan, cardio-facio-cutaneous and Costello syndromes. These syndromes, collectively called RASopathies, are caused by mutations in the RAS/MAPK pathway, which is known to play a major role in lymphangiogenesis. Recently, germline mutations in the Casitas B-cell lymphoma (CBL) gene were reported in 25 patients and of these, 20 had juvenile myelomonocytic leukemia (JMML)...
February 2015: American Journal of Medical Genetics. Part A
Francesco Macchini, Valerio Gentilino, Anna Morandi, Ernesto Leva
Fetal hydrothorax is associated with significant mortality. However, the development of fetal thoracoamniotic shunting has reduced the mortality rate. Fetal thoracoamniotic shunting can be characterized by significant complications, such as intrathoracic dislodgement of the catheter. The ideal management of dislodged catheters postnatally is not known. We report two newborns with a prenatal diagnosis of fetal hydrothorax who underwent thoracoamniotic shunting complicated by intrathoracic dislodgement of the catheters requiring thoracoscopic removal of the shunts in the neonatal period...
November 2014: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Helieh S Oz
Over 1 billion people globally are estimated to be infected with Toxoplasma gondii with severe or unknown consequences and no safe and effective therapies are available against congenital or persistent chronic infection. We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis. METHODS: Programmed pregnant mice were treated with atovaquone and diclazuril monotherapy, or combined (atovaquone + diclazuril) therapy and infected with tachyzoites (0, 300, 600) and the course of infection was studied...
August 2014: International Journal of Clinical Medicine
S Christopher Derderian, Shivika Trivedi, Jody Farrell, Roberta L Keller, Larry Rand, Ruth Goldstein, Vickie A Feldstein, Shinjiro Hirose, Tippi C MacKenzie
OBJECTIVE: Primary hydrothorax is a rare congenital anomaly with outcomes ranging from spontaneous resolution to fetal demise. We reviewed our experience with fetuses diagnosed with primary hydrothorax to evaluate prenatal management strategies. METHODS: We reviewed the records of patients evaluated for fetal pleural effusions at our Fetal Treatment Center between 1996 and 2013. To define fetuses with primary hydrothorax, we excluded those with structural or genetic anomalies, diffuse lymphangiectasia, immune hydrops, and monochorionic diamniotic twin gestations...
June 2014: Journal of Pediatric Surgery
Helieh S Oz, Thomas Tobin
BACKGROUND: Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection. HYPOTHESIS: Diclazuril to be safe in pregnancy and effective against gastrointestinal toxoplasmosis. METHODS: CD1 programmed pregnant mice were divided into groups and administered a diet containing diclazuril, or sham control...
January 1, 2014: International Journal of Clinical Medicine
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