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https://www.readbyqxmd.com/read/29166639/apobec3a-expression-in-penile-squamous-cell-carcinoma
#1
Martina Heller, Elena-Sophie Prigge, Adam Kaczorowski, Magnus von Knebel Doeberitz, Markus Hohenfellner, Stefan Duensing
BACKGROUND: APOBECs (apolipoprotein B mRNA-editing catalytic polypeptides) are cytidine deaminases that have been implicated in the host defense against viruses by blocking viral replication. They have also been shown to play a role in genome hypermutation in several human cancers. An APOBEC3 hypermutation signature has been discovered in cervical cancer, which is intimately associated with infection by high-risk human papillomaviruses (HPVs). At the same time, HPV genomes themselves are subject to DNA editing by APOBECs...
November 23, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29166482/abortion-and-sex-related-conditions-in-substance-dependent-brazilian-patients
#2
Alessandra Diehl, Sandra Cristina Pillon, Manoel Antonio Dos Santos, Ronaldo Laranjeira
Abortion is a very sensitive issue with relevance to public health; however few clinical or population-based studies have examined induced abortion among drug users. The study aims to evaluate the prevalence of induced abortion and sex-related conditions in an inpatient drug user sample. A cross-sectional design study was conducted in an inpatient addiction treatment unit in São Paulo, Brazil, with a sample of 616 patients, aged 18-75. Sociodemographic data, sexual behavior, and dependence severity were evaluated in relation to induced abortion...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166446/maternal-education-and-age-inequalities-in-neonatal-death
#3
Sandra Costa Fonseca, Patricia Viana Guimarães Flores, Kenneth Rochel Camargo, Rejane Sobrino Pinheiro, Claudia Medina Coeli
OBJECTIVE: Evaluate the interaction between maternal age and education level in neonatal mortality, as well as investigate the temporal evolution of neonatal mortality in each stratum formed by the combination of these two risk factors. METHODS: A nonconcurrent cohort study, resulting from a probabilistic relationship between the Mortality Information System and the Live Birth Information System. To investigate the risk of neonatal death we performed a logistic regression, with an odds ratio estimate for the combined variable of maternal education and age, as well as the evaluation of additive and multiplicative interaction...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166359/incisional-hernia-after-midline-versus-transverse-specimen-extraction-incision-a-randomized-trial-in-patients-undergoing-laparoscopic-colectomy
#4
Lawrence Lee, Juan Mata, Raoul A Droeser, Pepa Kaneva, Sender Liberman, Patrick Charlebois, Barry Stein, Gerald M Fried, Liane S Feldman
OBJECTIVE: To compare the incidence of incisional hernia (IH) between midline and transverse specimen extraction site in patients undergoing laparoscopic colectomy. BACKGROUND: Midline specimen extraction incision is most commonly used in laparoscopic colectomy, but has high IH risk. IH may be lower for transverse incision. METHODS: A single-center superiority trial was conducted. Eligible patients undergoing laparoscopic colectomy were randomly assigned to midline or transverse specimen extraction...
November 21, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29166319/cardiometabolic-impact-of-changing-sitting-standing-and-stepping-in-the-workplace
#5
Elisabeth Ah Winkler, Sebastien Chastin, Elizabeth G Eakin, Neville Owen, Anthony D LaMontagne, Marj Moodie, Paddy C Dempsey, Bronwyn A Kingwell, David W Dunstan, Genevieve N Healy
BACKGROUND: According to cross-sectional and acute experimental evidence, reducing sitting time should improve cardio-metabolic health risk biomarkers. Furthermore, the improvements obtained may depend on whether sitting is replaced with standing or ambulatory activities. Based on data from the Stand Up Victoria multi-component workplace intervention, we examined this issue using compositional data analysis - a method that can examine and compare all activity changes simultaneously. METHODS: Participants receiving the intervention (n=136 ≥0...
November 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29166201/warm-water-compress-as-an-alternative-for-decreasing-the-degree-of-phlebitis
#6
Fitri Annisa, Nani Nurhaeni, Dessie Wanda
Intravenous fluid therapy is an invasive procedure which may increase the risk of patient complications. One of the most common of these is phlebitis, which may cause discomfort and tissue damage. Therefore, a nursing intervention is needed to effectively treat phlebitis. The purpose of this study was to investigate the effectiveness of applying a warm compression intervention to reduce the degree of phlebitis. A quasi-experimental pre-test and post-test design was used, with a non-equivalent control group...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166147/preliminary-results-of-lung-cancer-screening-in-a-socioeconomically-disadvantaged-population
#7
Phillip L Guichet, Beringia Y Liu, Bhushan Desai, Zul Surani, Steven Y Cen, Christopher Lee
OBJECTIVE: The objective of our study was to describe the preliminary results of our clinical low-dose CT (LDCT) lung cancer screening program targeting a minority, socioeconomically disadvantaged, high-risk population different from that studied in the National Lung Screening Trial (NLST). MATERIALS AND METHODS: Community partner clinics in an underserved region of south Los Angeles County referred interested candidates to our program. All patients met National Comprehensive Cancer Network eligibility criteria for lung cancer screening...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166137/primary-constrained-tips-for-treating-refractory-ascites-or-variceal-bleeding-secondary-to-hepatic-cirrhosis
#8
R Rabei, S Mathesovian, J Tasse, S Madassery, B Arslan, U Turba, O Ahmed
PURPOSE: To report an initial experience using a primary constrained TIPS technique for treating cirrhotic patients with refractory ascites or variceal bleeding. METHODS: All patients undergoing primary constrained (n=9) and conventional (n=18) TIPS between July 2014 and June 2016 were retrospectively reviewed. Pre-procedure demographics, Child-Pugh (CP), MELD, and technical variables were recorded. Outcomes measured included technical and clinical success, complications, 30-day mortality, as well as necessity for TIPS revision...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29165712/use-of-an-articulating-hinge-to-facilitate-cervicothoracic-deformity-correction-during-vertebral-column-resection
#9
Rajiv R Iyer, Benjamin D Elder, Tomas Garzon-Muvdi, Justin M Sacks, Ian Suk, Jean-Paul Wolinsky
BACKGROUND: Surgical treatment of severe cervicothoracic kyphotic deformity may require the use of 3-column osteotomies such as the pedicle subtraction osteotomy and vertebral column resection (VCR), or VCR with anterior longitudinal ligament resection. Such procedures are extensive and are associated with high intra- and perioperative morbidity, in part, due to the need for risky reduction maneuvers. OBJECTIVE: To describe a novel technique utilizing a laterally placed articulating hinge to facilitate kyphotic deformity correction of the cervicothoracic spine...
November 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29165636/reducing-redundant-anaerobic-therapy-through-spaced-education-and-antimicrobial-stewardship-interventions
#10
Kelly B Flett, Athos Bousvaros, Jane Carpenter, Carly E Millrinen, Patricia Martin, Thomas J Sandora
Background: Decreasing the use of redundant anaerobic therapy is a key target for antimicrobial stewardship. Education techniques that optimize knowledge retention could be an important component of reducing these regimens. Methods: We implemented a quality improvement project that incorporated spaced education to reduce the use of redundant anaerobic therapy. The initial interventions (November through December 2015) included education in a hospital-wide newsletter and review of redundant anaerobic regimens by the antimicrobial stewardship program...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29165583/modelling-projections-for-the-risks-related-with-atrial-fibrillation-in-east-asia-a-focus-on-ischaemic-stroke-and-death
#11
Ying Bai, Shi-Dong Guo, Alena Shantsila, Gregory Y H Lip
Aims: In the Far East, there has generally been low uptake of oral anticoagulants (OACs) using vitamin K antagonists (VKA, e.g. warfarin) for stroke prevention in atrial fibrillation (AF), but OAC use has been increasing more recently, with the introduction of the non-vitamin K antagonist oral anticoagulants (NOACs). To explore the risks of ischaemic stroke (IS) and death related to AF in East Asia using modelling projections. Methods and results: We performed a modelling analysis of possible trends of IS and death rates in AF patients from the time period of only VKA use to current increasing trends of NOAC use projecting until 2050 in East Asia...
November 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29165553/solvent-transfer-efficiency-of-risk-management-measures
#12
Katharina Bluemlein, Manfred Elend, Tim Meijster, Alison Margary, Rosalie Tibaldi, Stefan Hahn, Susanne Hesse
A series of laboratory simulations were conducted in order to determine the airborne protection that might be afforded by different combinations of workplace exposure controls typically encountered when handling volatile solvents (e.g. solvent transfer). These conditions, referred to as risk management measures (RMMs) under the Registration, Evaluation and Authorisation of Chemicals Regulation (REACH), are typically described using standard phrases in safety data sheets [and specifically those of the European Phrase Catalogue (EUPhraC)]...
November 19, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29165170/evaluating-prevalence-and-risk-factors-of-building-related-symptoms-among-office-workers-seasonal-characteristics-of-symptoms-and-psychosocial-and-physical-environmental-factors
#13
Kenichi Azuma, Koichi Ikeda, Naoki Kagi, U Yanagi, Haruki Osawa
BACKGROUND: Psychosocial and environmental factors at the workplace play a significant role in building-related symptoms (BRSs). Environmental factors change during summer cooling and winter heating using air-conditioning systems. Thus, significant risk factors in each season need to be clarified. METHODS: A nationwide cross-sectional study was conducted during summer in Japan and seasonal differences between summer and winter were evaluated. Self-administered questionnaires were distributed to 489 offices...
April 12, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165169/cardiovascular-effects-of-linalyl-acetate-in-acute-nicotine-exposure
#14
Ju Ri Kim, Purum Kang, Hui Su Lee, Ka Young Kim, Geun Hee Seol
BACKGROUD: Smoking is a risk factor for cardiovascular diseases as well as pulmonary dysfunction. In particular, adolescent smoking has been reported to have a higher latent risk for cardiovascular disease. Despite the risk to and vulnerability of adolescents to smoking, the mechanisms underlying the effects of acute nicotine exposure on adolescents remain unknown. This study therefore evaluated the mechanism underlying the effects of linalyl acetate on cardiovascular changes in adolescent rats with acute nicotine exposure...
April 24, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165150/search-for-biomarkers-of-asbestos-exposure-and-asbestos-induced-cancers-in-investigations-of-the-immunological-effects-of-asbestos
#15
REVIEW
Hidenori Matsuzaki, Naoko Kumagai-Takei, Suni Lee, Megumi Maeda, Nagisa Sada, Tamayo Hatayama, Shoko Yamamoto, Miho Ikeda, Kei Yoshitome, Yu Min, Yasumitsu Nishimura, Takemi Otsuki
The immunological effects of asbestos exposure on various lymphocytes such as the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were investigated. Results show that asbestos exposure impairs antitumor immunity through enhancement of regulatory T cell function and volume, reduction of CXCR3 chemokine receptor in responder CD4+ T helper cells, and impairment of the killing activities of CD8+ cytotoxic T lymphocytes (CTL) and NK cells...
June 9, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165021/two-years-of-tamoxifen-or-no-adjuvant-systemic-therapy-for-patients-with-high-risk-breast-cancer-long-term-follow-up-of-the-copenhagen-breast-cancer-trial
#16
Maj-Britt Jensen, Jens Fabricius Krarup, Torben Palshof, Henning T Mouridsen, Bent Ejlertsen
BACKGROUND: The Copenhagen Breast Cancer Trial (CBCT) randomly assigned patients with early breast cancer to two years of tamoxifen or placebo and we evaluated the effect over the following four decades. PATIENT AND METHODS: Between 1975 and 1978, 327 patients with primary breast cancer were randomly assigned to two years of daily placebo or tamoxifen. Survival statistics was collected from the Danish Civil Registration System. RESULTS: The five-year invasive breast cancer recurrence (BCR) rate was 43...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164845/current-therapeutic-options-and-treatments-in-development-for-the-management-of-primary-open-angle-glaucoma
#17
Jeffrey M Liebmann, Jeannie K Lee
Primary open angle glaucoma (POAG) is the most common type of glaucoma, and is responsible for approximately 90% of glaucoma cases in North America. POAG is characterized by an asymptomatic onset, where patients do not present with symptoms until significant visual loss occurs in late stages of the disease. Importantly, while glaucoma is associated with several risk factors that contribute to damage and disease progression, intraocular pressure (IOP) is the only proven modifiable risk factor at this time. Treatments for POAG include use of pharmacologic and surgical interventions...
September 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29164798/regionally-specific-changes-in-the-hippocampal-circuitry-accompany-progression-of-cerebrospinal-fluid-biomarkers-in-preclinical-alzheimer-s-disease
#18
Christine L Tardif, Gabriel A Devenyi, Robert S C Amaral, Sandra Pelleieux, Judes Poirier, Pedro Rosa-Neto, John Breitner, M Mallar Chakravarty
Neuropathological and in vivo brain imaging studies agree that the cornu ammonis 1 and subiculum subfields of the hippocampus are most vulnerable to atrophy in the prodromal phases of Alzheimer's disease (AD). However, there has been limited investigation of the structural integrity of the components of the hippocampal circuit, including subfields and extra-hippocampal white matter structure, in relation to the progression of well-accepted cerebrospinal fluid (CSF) biomarkers of AD, amyloid-β 1-42 (Aβ) and total-tau (tau)...
November 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29164675/significance-of-day-1-viral-response-of-hepatitis-c-virus-in-patients-with-chronic-hepatitis-c-receiving-direct-acting-antiviral-therapy
#19
Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Tsuyoki Yama, Kazuyuki Mizuno
BACKGROUND AND AIM: On-treatment response of serum hepatitis C virus (HCV) is reportedly less useful to predict the outcome of anti-HCV therapy with interferon (IFN)-free regimen with direct-acting antivirals (DAAs) than with IFN-based regimens in clinical trials. We evaluated the significance of very early viral response after the start of therapy, which indicates direct HCV response to the drugs, on therapeutic outcome. METHODS: Reductions in serum HCV RNA levels were measured at 1day after the start of therapy in 544 patients who underwent IFN-free DAA regimens...
November 22, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29164519/atorvastatin-prevents-early-oxidative-events-and-modulates-inflammatory-mediators-in-the-striatum-following-intranasal-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-mptp-administration-in-rats
#20
Naiani F Marques, Adalberto A Castro, Gianni Mancini, Fernanda L Rocha, Adair R S Santos, Rui D Prediger, Andreza Fabro De Bem, Carla I Tasca
Atorvastatin is a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor with cholesterol-lowering, anti-inflammatory, and antioxidant properties. Increasing evidence show atorvastatin acts as a protective agent against insults in the central nervous system (CNS). The regular use of statins has been associated with a reduced risk of Parkinson's disease (PD) development. Here, we evaluated early events involved in the neurotoxicity induced by intranasal (i.n.) infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats and the potential of atorvastatin to prevent these early toxic events...
November 21, 2017: Neurotoxicity Research
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