keyword
MENU ▼
Read by QxMD icon Read
search

muscle relaxant

keyword
https://www.readbyqxmd.com/read/28549064/chemomechanical-regulation-of-myosin-ic-cross-bridges-deducing-the-elastic-properties-of-an-ensemble-from-single-molecule-mechanisms
#1
Florian Berger, A J Hudspeth
Myosin Ic is thought to be the principal constituent of the motor that adjusts mechanical responsiveness during adaptation to prolonged stimuli by hair cells, the sensory receptors of the inner ear. In this context myosin molecules operate neither as filaments, as occurs in muscles, nor as single or few molecules, as characterizes intracellular transport. Instead, myosin Ic molecules occur in a complex cluster in which they may exhibit cooperative properties. To better understand the motor's remarkable function, we introduce a theoretical description of myosin Ic's chemomechanical cycle based on experimental data from recent single-molecule studies...
May 26, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28546966/effects-of-progressive-muscle-relaxation-guided-imagery-and-deep-diaphragmatic-breathing-on-quality-of-life-in-elderly-with-breast-or-prostate-cancer
#2
Mohsen Shahriari, Mojtaba Dehghan, Saeid Pahlavanzadeh, Abdolrahim Hazini
BACKGROUND AND OBJECTIVES: Due to the increasing number of elderly and an increase in the number of cases of cancer by age, cancer is a common problem in the elderly. For elderly patients with cancer, the disease and its treatment can have long-term negative effects on their quality of life (QoL). The purpose of this study was to evaluate the effect of progressive muscle relaxation, body image and deep diaphragmatic breathing on the QoL in the elderly with cancer. MATERIALS AND METHODS: This study was a randomized controlled trial in which 50 elderly patients with breast or prostate cancer were randomized into study and control groups...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28540214/coronary-microvascular-dysfunction-in-women-with-nonobstructive-ischemic-heart-disease-as-assessed-by-positron-emission-tomography
#3
REVIEW
Roxana Campisi, Fernando D Marengo
Traditional approaches for risk assessment of ischemic heart disease (IHD) are based on the physiological consequences of an epicardial coronary stenosis. Of note, normal coronary arteries or nonobstructive coronary artery disease (CAD) is a common finding in women with signs and symptoms of ischemia. Therefore, assessment of risk based on a coronary stenosis approach may fail in women. Positron emission tomography (PET) quantifies absolute myocardial blood flow (MBF) which may help to elucidate other mechanisms involved such as endothelial dysfunction and alterations in the smooth muscle cell relaxation responsible for IHD in women...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28540168/arterial-relaxation-is-coupled-to-inhibition-of-mitochondrial-fission-in-arterial-smooth-muscle-cells-comparison-of-vasorelaxant-effects-of-verapamil-and-phentolamine
#4
Jing Jin, Xin Shen, Yu Tai, Shanliang Li, Mingyu Liu, Changlin Zhen, Xiuchen Xuan, Xiyue Zhang, Nan Hu, Xinzi Zhang, Deli Dong
Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of mitochondrial fission in smooth muscle cells was associated with arterial relaxation. Here, we used the typical vasorelaxants, verapamil and phentolamine, to further confirm the coupling between arterial constriction and mitochondrial fission in rat aorta. Results showed that phentolamine but not verapamil induced vasorelaxation in phenylephrine (PE)-induced rat thoracic aorta constriction...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539690/myotonometry-reliably-measures-muscle-stiffness-in-the-thenar-and-perineal-muscles
#5
Melissa J Davidson, Adam L Bryant, Wendy F Bower, Helena C Frawley
Purpose: The authors investigated the reliability of myotonometry-measured muscle tone in the thenar and perineal muscles. Methods: Participants were women aged 18-50 years who were asymptomatic for thumb and pelvic floor dysfunction (interrater study n=20; intrarater study n=43) or who were symptomatic for vulvodynia (interrater study n=14; intrarater study n=32). Mechanical properties (stiffness, frequency, decrement, relaxation time, and creep) of the muscles were measured using a myotonometer (MyotonPRO) while the muscles were in a relaxed state...
2017: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/28539337/altered-expression-and-modulation-of-the-two-pore-domain-k2p-mechano-gated-potassium-channel-trek-1-in-overactive-human-detrusor
#6
Ricardo H Pineda, Balachandar Nedumaran, Joseph A Hypolite, Xiao-Qing Pan, Shandra Wilson, Randall B Meacham, Anna P Malykhina
Background Detrusor overactivity (DO) is the abnormal response of the urinary bladder to physiological stretch during the filling phase of the micturition cycle. The mechanisms of bladder smooth muscle compliance upon the wall stretch are poorly understood. We previously reported that the function of normal detrusor is regulated by TREK-1, a member of the mechano-gated subfamily of two-pore domain potassium (K2P) channels. In the present study, we aimed to identify the changes in expression and function of TREK-1 channels under pathological conditions associated with DO, evaluate the potential relationship between TREK-1 channels and cytoskeletal proteins in the human bladder, and test the possibility of modulation of TREK-1 channel expression by small RNAs...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28536810/fibromyalgia-treating-pain-in-the-juvenile-patient
#7
REVIEW
Sabrina Gmuca, David D Sherry
Presently, evidence for the efficacy of medications for the treatment of juvenile fibromyalgia syndrome (JFMS) is limited. While there are medications approved by the US Food and Drug Administration (duloxetine, milnacipran and pregabalin) for adults with fibromyalgia syndrome, there are none for the treatment of JFMS. A variety of medications have been prescribed for the treatment of JFMS, including (but not limited to) non-opioid analgesics, opioids, anticonvulsants, antidepressants, and muscle relaxants...
May 23, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28532040/design-synthesis-and-characterization-of-poly-methacrylic-acid-niclosamide-and-its-effect-on-arterial-function
#8
Rui Ma, Zhen-Gang Ma, Chang-Lin Zhen, Xin Shen, Shan-Liang Li, Li Li, Yu-Feng Zheng, De-Li Dong, Zhi-Jie Sun
We have found that niclosamide induced relaxation of constricted artery. However, niclosamide is insoluble, the low bioavailability and the resultant low plasma concentration limit its potential exertion in vivo. The aim of the present study is to synthesize a soluble poly (methacrylic acid-niclosamide) polymer (PMAN) and study the effects of PMAN on arterial function in vitro and the blood pressure and heart rate of rats in vivo. We synthesized the poly (methacrylic acid-niclosamide) polymer (PMAN), the chemical structure of which was identified by FTIR and (1)H NMR spectra...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28528595/implications-of-white-striping-and-spaghetti-meat-abnormalities-on-meat-quality-and-histological-features-in-broilers
#9
G Baldi, F Soglia, M Mazzoni, F Sirri, L Canonico, E Babini, L Laghi, C Cavani, M Petracci
During the past few years, there has been an increasing prevalence of broiler breast muscle abnormalities, such as white striping (WS) and wooden breast conditions. More recently, a new muscular abnormality termed as spaghetti meat (SM) because of the altered structural integrity of the Pectoralis major muscle often associated with WS has emerged. Thus, this study aimed at evaluating the effects of WS and SM conditions, occurring alone or combined within the same P. major muscle, on meat quality traits and muscle histology...
May 22, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28518407/nad-a-big-player-in-cardiac-and-skeletal-muscle-remodeling-and-aging
#10
REVIEW
Pankaj Chaturvedi, Suresh C Tyagi
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and antiaging molecule. A paper in science by Zhang et al (2016) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al (2002) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al (2002) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure...
May 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28515177/do-%C3%AE-3-adrenoceptor-agonists-cause-urinary-bladder-smooth-muscle-relaxation-by-inhibiting-acetylcholine-release
#11
Katerina Okeke, Stavros Gravas, Martin C Michel
The mechanisms leading to improvement of overactive bladder syndrome upon treatment with a β3-adrenoceptor agonist remain controversial. New research points to a role of inhibition of neuronal acetylcholine release. Whether this occurs by a direct effect on prejunctional β3-adrenoceptors or indirectly by formation of adenosine and activation of A1 adenosine receptors is being discussed.
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28515053/berberine-reduced-blood-pressure-and-improved-vasodilation-in-diabetic-rats
#12
Yu-Guang Ma, Liang Liang, Yin-Bin Zhang, Bao-Feng Wang, Yun-Gang Bai, Zhi-Jun Dai, Man-Jiang Xie, Zhong-Wei Wang
Hyperglycemia and hypertension are considered to be the two leading risk factors for vascular disease in diabetic patients. However, few pharmacologic agents could provide a combinational therapy for controlling hyperglycemia and hypertension at the same time in diabetes. We aimed to investigate whether berberine treatment could directly reduce blood pressure in diabetes and what is the molecular mechanism underlying the vascular protection of berberine in diabetic rats. Berberine (50, 100, and 200 mg/kg/day) was intragastrically administered to diabetic rats for 8 weeks since the injection of streptozotocin...
May 17, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28509775/failed-vocalis-muscle-monitoring-during-thyroid-surgery-resulting-from-residual-muscle-relaxation
#13
Stuart D Marshall, Jonathan Serpell
No abstract text is available yet for this article.
May 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28509762/beetroot-juice-increases-human-muscle-force-without-changing-ca2-handling-proteins
#14
Jamie Whitfield, Daniel Gamu, George J F Heigenhauser, Luc J C van Loon, Lawrence L Spriet, A Russell Tupling, Graham P Holloway
Dietary inorganic nitrate (NO3) supplementation improves skeletal muscle (SkM) contractile efficiency, and while rodent literature has suggested improvements in calcium handling or redox modifications as likely explanations, the direct mechanism-of-action in humans remains unknown. PURPOSE: To examine the effects of 7-d of beetroot juice (BRJ) supplementation on SkM contractile characteristics and function. METHODS: Recreationally active males (n=8) underwent transcutaneous electrical muscle stimulation of the vastus lateralis for evaluation of contractile characteristics before (pre) and after (post) 7-d of BRJ supplementation (280 mL/day, ~26 mmol NO3)...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28502777/peripheral-muscle-fatigue-in-hospitalised-geriatric-patients-is-associated-with-circulating-markers-of-inflammation
#15
Pauline Arnold, Rose Njemini, Stijn Vantieghem, Jacques Duchateau, Tony Mets, Ingo Beyer, Ivan Bautmans
Geriatric patients with acute infection show increased muscle weakness and fatigability but the relative contribution of central and peripheral factors is unclear. Hospitalised patients with acute infection (82±6years, N=10) and community-dwelling controls (76±6years, N=19) sustained a maximal voluntary isometric contraction of the M. Adductor Pollicis until strength dropped to 50% of its maximal value. Voluntary muscle activation (VA) was assessed before and at the end of the fatigue protocol using twitch interpolation method and muscle activity was monitored using surface electromyography...
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502541/prolonged-stance-phase-during-walking-in-intermittent-claudication
#16
Lindy N M Gommans, Annemieke T Smid, Marc R M Scheltinga, Ernst Cancrinus, Frans A M Brooijmans, Kenneth Meijer, Joep A W Teijink
BACKGROUND: Patients with intermittent claudication (IC) tend to walk slower and consume approximately 40% more oxygen during walking compared with healthy individuals. An unfavorable locomotion pattern has been suggested to explain this metabolic inefficiency. However, detailed knowledge of gait parameters in IC is lacking. METHODS: In a cross-sectional study, the gait pattern of newly diagnosed IC patients was compared with that of healthy controls. Spatiotemporal gait parameters such as step length and duration of stance phase were obtained by a photoelectric technique (OptoGait; Microgate, Bolzano, Italy)...
May 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28502408/combined-effect-of-low-back-muscle-fatigue-and-passive-tissue-elongation-on-the-flexion-relaxation-response
#17
Sangeun Jin, Gary A Mirka
Previous literature has documented the alterations in the flexion-relaxation response of the lumbar extensor musculature to passive tissue elongation (PTE) and muscle fatigue (MF). There is no study, however, that has explored this response as a function of the combined effect of both PTE and MF, which is often seen in occupational settings. Twelve participants performed three experimental protocols on three different days to achieve (1) PTE, (2) MF and (3) PTE&MF (combined). Trunk kinematics and muscle activities were monitored to assess the effects of these protocols on the peak lumbar flexion angle and the lumbar angle of the flexion-relaxation of the trunk extensor muscles...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28501682/the-role-of-arachidonic-acid-cyclooxygenase-cascade-phosphodiesterase-iv-and-rho-kinase-in-h2s-induced-relaxation-in-the-mouse-corpus-cavernosum
#18
Fatma Aydinoglu, Nuran Ogulener
BACKGROUND: Penile corpus cavernosum is an extremely vascularized tissue and cavernosal smooth muscle tone is regulated by the balance between contractile and relaxant factor. We investigated the possible role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV (PDEIV) and Rho-kinase in exogenous hydrogen sulfide (H2S)-induced relaxation in mouse corpus cavernosum. METHODS: The relaxant response to H2S (NaHS as exogenous H2S; 1-1000μM) were obtained in isolated mouse corpus cavernosum tissues which pre-contracted by phenylephrine (5μM)...
February 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28497497/simultaneous-measurement-of-macro-and-microvascular-blood-flow-and-oxygen-saturation-for-quantification-of-muscle-oxygen-consumption
#19
Erin K Englund, Zachary B Rodgers, Michael C Langham, Emile R Mohler, Thomas F Floyd, Felix W Wehrli
PURPOSE: To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called "Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*" (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*, all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( V˙O2) via the Fick principle...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28497396/progressive-muscle-relaxation-combined-with-chinese-medicine-five-element-music-on-depression-for-cancer-patients-a-randomized-controlled-trial
#20
Juan Liao, Yu Wu, Yang Zhao, Yuan-Chen Zhao, Xu Zhang, Nan Zhao, Chun-Ging Lee, Yu-Fei Yang
OBJECTIVES: To evaluate the effects of progressive muscle relaxation training (PMRT) combined with fifive elements music therapy of Chinese medicine (CM) for improving anxiety and depression of cancer patients. METHODS: From June 2015 to March 2016, 60 cancer patients were included into the study. The patients were randomly assigned to a control group and a treatment group by envelope randomization, receiving PMRT and PMRT plus CM five elements music therapy, respectively, for 8 weeks...
May 11, 2017: Chinese Journal of Integrative Medicine
keyword
keyword
33125
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"