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https://www.readbyqxmd.com/read/29244953/metaqsar-an-integrated-database-engine-to-manage-and-analyze-metabolic-data
#1
Alessandro Pedretti, Angelica Mazzolari, Giulio Vistoli, Bernard Testa
The study describes the MetaQSAR tool, a new database engine specifically tailored to collect and analyze metabolic data. This is a plug-in embedded in the VEGA suite of programs (freely downloadable at www.vegazz.net) and takes advantage from all cheminformatics features implemented in the software with additional tools aimed to perform statistical analyses, similarity searches and physicochemical profiling of the stored molecules. MetaQSAR also implements a novel metabolism classification, which groups the metabolic reactions in 101 classes and can find numerous applications in metabolic analyses...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29244758/protein-subcellular-localization-with-gaussian-kernel-discriminant-analysis-and-its-kernel-parameter-selection
#2
Shunfang Wang, Bing Nie, Kun Yue, Yu Fei, Wenjia Li, Dongshu Xu
Kernel discriminant analysis (KDA) is a dimension reduction and classification algorithm based on nonlinear kernel trick, which can be novelly used to treat high-dimensional and complex biological data before undergoing classification processes such as protein subcellular localization. Kernel parameters make a great impact on the performance of the KDA model. Specifically, for KDA with the popular Gaussian kernel, to select the scale parameter is still a challenging problem. Thus, this paper introduces the KDA method and proposes a new method for Gaussian kernel parameter selection depending on the fact that the differences between reconstruction errors of edge normal samples and those of interior normal samples should be maximized for certain suitable kernel parameters...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244222/diffusion-weighted-imaging-features-of-breast-tumours-and-the-surrounding-stroma-reflect-intrinsic-heterogeneous-characteristics-of-molecular-subtypes-in-breast-cancer
#3
Ming Fan, Ting He, Peng Zhang, Hu Cheng, Juan Zhang, Xin Gao, Lihua Li
Breast cancer heterogeneity is the main obstacle preventing the identification of patients with breast cancer with poor prognoses and treatment responses; however, such heterogeneity has not been well characterized. The purpose of this retrospective study was to reveal heterogeneous patterns in the apparent diffusion coefficient (ADC) signals in tumours and the surrounding stroma to predict molecular subtypes of breast cancer. A dataset of 126 patients with breast cancer, who underwent preoperative diffusion-weighted imaging (DWI) on a 3...
December 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29244220/closing-the-gap-structural-evidence-for-the-missing-hexabromide-dianion-br6-2
#4
Sebastian Hasenstab-Riedel, Karsten Sonnenberg, Patrick Pröhm, Helmut Beckers, Simon Steinhauer, Carsten Müller, Dieter Lentz
The formation and experimental characterization of the first hexabromide dianion is presented. This dianion fills the last remaining gap in the series of polybromides from the tribromide [Br3]- to the undecabromide [Br11]-. The experimental results are compared to quantum-chemical calculations. These calculations predict¬ - based on electrostatic interactions - a T-structure for the hexabromide dianion, while halogen-halogen bonding favors the hockey-stick like structure experimentally found in the solid-state structure...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29244202/mental-health-risk-adjustment-with-clinical-categories-and-machine-learning
#5
Akritee Shrestha, Savannah Bergquist, Ellen Montz, Sherri Rose
OBJECTIVE: To propose nonparametric ensemble machine learning for mental health and substance use disorders (MHSUD) spending risk adjustment formulas, including considering Clinical Classification Software (CCS) categories as diagnostic covariates over the commonly used Hierarchical Condition Category (HCC) system. DATA SOURCES: 2012-2013 Truven MarketScan database. STUDY DESIGN: We implement 21 algorithms to predict MHSUD spending, as well as a weighted combination of these algorithms called super learning...
December 15, 2017: Health Services Research
https://www.readbyqxmd.com/read/29244037/a-psychometric-evaluation-of-the-chinese-version-of-the-m-d-anderson-symptom-inventory-heart-failure-in-chinese-cancer-patients-with-concurrent-heart-failure
#6
Sek Ying Chair, Qun Wang, Mingming Yu, Winnie Kwok Wei So, Chang Tian, Janet Wing Hung Sit, Eliza Mi Ling Wong, Carmen Wing Han Chan, Anecita Fadol
PURPOSE: The purpose of the study was to translate the M.D. Anderson Symptom Inventory-Heart Failure (MDASI-HF), a specific instrument to assess symptoms in cancer patients with concurrent heart failure (HF), into Mandarin Chinese and to examine its psychometric properties in Chinese cancer patients. DESIGN: A translation and psychometric evaluation design was used. METHODS: The translation of the MDASI-HF into Mandarin Chinese followed Brislin's model with the four steps: translation, monolingual assessment, backward translation, and comparison...
November 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29244002/higher-recall-in-metagenomic-sequence-classification-exploiting-overlapping-reads
#7
Samuele Girotto, Matteo Comin, Cinzia Pizzi
BACKGROUND: In recent years several different fields, such as ecology, medicine and microbiology, have experienced an unprecedented development due to the possibility of direct sequencing of microbioimic samples. Among problems that researchers in the field have to deal with, taxonomic classification of metagenomic reads is one of the most challenging. State of the art methods classify single reads with almost 100% precision. However, very often, the performance in terms of recall falls at about 50%...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29244000/identification-of-recent-cases-of-hepatitis-c-virus-infection-using-physical-chemical-properties-of-hypervariable-region-1-and-a-radial-basis-function-neural-network-classifier
#8
James Lara, Mahder Teka, Yury Khudyakov
BACKGROUND: Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identification of acute HCV infection. However, owing to complexity, both approaches are not efficient. Here, we describe a new sequence alignment-free method to discriminate between recent (R) and chronic (C) HCV infection using next-generation sequencing (NGS) data derived from the HCV hypervariable region 1 (HVR1)...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243999/efficacy-of-intraoperative-epidural-triamcinolone-application-in-lumbar-microdiscectomy-a-matched-control-study
#9
Martin N Stienen, Holger Joswig, Ivan Chau, Marian C Neidert, David Bellut, Thomas Wälchli, Karl Schaller, Oliver P Gautschi
OBJECTIVE The purpose of this study was to investigate whether the intraoperative application of an epidural steroid (ES) on the decompressed nerve root improves short- and midterm subjective and objective clinical outcomes after lumbar microdiscectomy. METHODS This study was a retrospective analysis of a 2-center database including consecutive cases in which patients underwent lumbar microdiscectomy. All patients who received ES application (40 mg triamcinolone, ES group) were matched by age and sex to patients who had not received ES application (control group)...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29243982/endoscopic-transorbital-superior-eyelid-approach-anatomical-study-from-a-neurosurgical-perspective
#10
Alberto Di Somma, Norberto Andaluz, Luigi Maria Cavallo, Matteo de Notaris, Iacopo Dallan, Domenico Solari, Lee A Zimmer, Jeffrey T Keller, Mario Zuccarello, Alberto Prats-Galino, Paolo Cappabianca
OBJECTIVE Recent studies have proposed the superior eyelid endoscopic transorbital approach as a new minimally invasive route to access orbital lesions, mostly in otolaryngology and maxillofacial surgeries. The authors undertook this anatomical study in order to contribute a neurosurgical perspective, exploring the anterior and middle cranial fossa areas through this purely endoscopic transorbital trajectory. METHODS Anatomical dissections were performed in 10 human cadaveric heads (20 sides) using 0° and 30° endoscopes...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243825/dermatologic-manifestations-among-human-immunodeficiency-virus-patients-in-morocco-and-association-with-immune-status
#11
Hicham Titou, Christelle Ebongo, Naoufal Hjira
OBJECTIVE: The objective was to determine if the type and number of skin diseases can be clinical indicators of underlying immune status in HIV1 disease by estimating and correlating with the CD4 count and CDC stage. MATERIALS AND METHODS: This was a retrospective cross-sectional descriptive study. All consecutive patients infected with HIV1 followed at the Dermatology Department of Rabat Military Hospital between January 2008 and January 2017 were studied for dermatological manifestations, CD4 count and CDC clinical stage...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29243572/development-dissemination-and-applications-of-a-new-terminological-resource-the-q-code-taxonomy-for-professional-aspects-of-general-practice-family-medicine
#12
Marc Jamoulle, Melissa Resnick, Julien Grosjean, Ashwin Ittoo, Elena Cardillo, Robert Vander Stichele, Stefan Darmoni, Marc Vanmeerbeek
BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC...
December 15, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29243554/parametric-estimates-for-the-receiver-operating-characteristic-curve-generalization-for-non-monotone-relationships
#13
Pablo Martínez-Camblor, Juan C Pardo-Fernández
Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, this is equivalent to fix a region or classification subset and then check if the observed value of the marker belongs to that region. Receiver operating characteristic curve is a valuable and popular tool to study and compare the diagnostic ability of a given marker. Besides, the area under the receiver operating characteristic curve is frequently used as an index of the global discrimination ability...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29243441/-efficacy-and-safety-of-kuhuang-injection-in-treating-viral-hepatitis%C3%AF-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Jun Zhao, Xing Liao, Hui Zhao, Jing Yang, Wen Zou, Le Wang, Ying-Jie Zhi
To systematically evaluate the effectiveness and safety of Kuhuang injection in treating viral hepatitis. Eight electronic databases and clinic trials were searched to collect randomized controlled trials for the effect of Kuhuang injection in the treatment of viral hepatitis. According to the Cochrane Handbook 5.1, two independent reviewers screened out the literatures, extracted data and assessed the quality of thestudies included. RevMan5.3 software was used for the data analysis. A total of 32 articles were included, involving 3 188 patients, including male 1 951 cases (61...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243407/rheumatic-diseases-are-associated-with-a-higher-risk-of-dementia-a-nation-wide-population-based-case-control-study
#15
Kuan-Ting Chen, Yen-Chung Chen, Yu-Hsi Fan, Wen-Xiu Lin, Wun-Cin Lin, Yu-Hsun Wang, Lichi Lin, Jeng-Yuan Chiou, James C-C Wei
AIM: Previous research demonstrated the possible relevance of dementia and rheumatic diseases. This population-based study aims to investigate the association of rheumatic diseases and dementia. METHODS: The data of this case-control study was extracted from the Taiwan National Health Insurance Research Database. Diagnosis of dementia and rheumatic diseases mentioned in this study were retrieved by the International Classification of Diseases-9 code. We recruited cases (n = 10 180) with dementia and controls (n = 61 080) during 2000-2010, by matching on age, gender and index date with a match ratio 1 : 6...
December 15, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29243394/the-banff-2017-kidney-meeting-report-revised-diagnostic-criteria-for-chronic-active-t-cell-mediated-rejection-antibody-mediated-rejection-and-prospects-for-integrative-endpoints-for-next-generation-clinical-trials
#16
M Haas, A Loupy, C Lefaucheur, C Roufosse, D Glotz, D Seron, B J Nankivell, P F Halloran, R B Colvin, N Alachkar, S Bagnasco, Y Bouatou, J U Becker, L Cornell, J P Duong van Huyen, I Gibson, R Mannon, M Naesens, V Nickeleit, P Nickerson, D L Segev, H K Singh, M Stegall, P Randhawa, L Racusen, K Solez, M Mengel
The kidney sessions of the 2017 Banff Conference focused on two areas: clinical implications of inflammation in areas of interstitial fibrosis and tubular atrophy (i-IFTA) and its relationship to T cell-mediated rejection (TCMR), and the continued evolution of molecular diagnostics, particularly in the diagnosis of antibody-mediated rejection (ABMR). In confirmation of previous studies, it was independently demonstrated by two groups that i-IFTA is associated with reduced graft survival. Furthermore, these groups presented that i-IFTA, particularly when involving >25% of sclerotic cortex in association with tubulitis, is often a sequela of acute TCMR in association with under-immunosuppression...
December 15, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29243374/molecular-classification-of-autofluorescence-excision-margins-in-oral-potentially-malignant-disorders
#17
Camile S Farah, Farzaneh Kordbacheh, Keziah John, Nigel Bennett, Simon A Fox
OBJECTIVE: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles. MATERIALS AND METHODS: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other...
December 14, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29243197/dimensional-latent-structure-of-early-disruptive-behavior-disorders-a-taxometric-analysis-in-preschoolers
#18
Sören Kliem, Nina Heinrichs, Anna Lohmann, Regina Bussing, Gudrun Schwarzer, Wolfgang Briegel
Although disruptive behavior disorders (DBDs) are used as a distinct categorical diagnosis in clinical practice, they have repeatedly been described as having a dimensional structure in taxometric analyses. In the current study the authors analyzed the latent status of disruptive behaviors (DB) in a large sample (N = 2,808) of German preschool children (2-6 years old, mean age 53.7 months, SD = 13.5, 48.4% girls). The Eyberg Child Behavior Inventory (ECBI) as well as the Strengths and Difficulties Questionnaire (SDQ) were used to compile indicators of the DB core dimensions (Temper Loss, Aggression, Noncompliance, and Low Concern for others)...
December 15, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29243195/indication-for-endoscopic-treatment-based-on-the-risk-of-lymph-node-metastasis-in-patients-with-siewert-type-ii-iii-early-gastric-cancer
#19
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Soohyun Ahn, Jae J Kim
BACKGROUND: Because of the poor prognosis of proximal gastric cancers, there is debate as to whether the conventional indications for endoscopic resection can be used. METHODS: Among subjects who underwent surgery for esophagogastric junction or gastric cardia cancer, 256 patients with T1 type II/III of the Siewert classification were included in this study. The association of lymph node metastasis (LNM) with each variable was analyzed using logistic regression models...
December 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29243173/magnetic-resonance-imaging-findings-of-two-cases-with-multinodular-and-vacuolating-neuronal-tumor
#20
Erkan Gökçe
Multinodular and vacuolating neuronal tumors (MVNT) are low grade neuronal tumors classified in cerebral tumors based on 2016 WHO central nerve system classification. Previously, MVNTs were probably tumors incidentally determined by imaging methods, but they could not be diagnosed or they were misdiagnosed. Two cases are reported in the present study, for which radiological imaging was carried out for epilepsy in one and for headache in the other. The first case was a twenty seven years old female patient with headache complaint...
December 14, 2017: Acta Neurologica Belgica
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