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Orbital disease

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https://www.readbyqxmd.com/read/29781834/ocular-findings-in-exfoliation-syndrome
#1
Robert Ritch
Exfoliation syndrome (XFS) is characterized by numerous ocular manifestations, the most important of these being glaucoma and cataract. Its ocular manifestations affect all of the structures of the anterior segment as well as conjunctiva and orbital structures. Exfoliation material is seen most prominently as characteristic white deposits on the anterior surface of the lens and the pupillary border of the iris. Both open-angle and angle-closure glaucoma are intimately associated with XFS. Other findings include zonular disruption, iris sphincter fibrosis, keratopathy, ocular surface disease, and retinal vein occlusion...
May 17, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29780942/successful-reconstruction-of-an-ocular-defect-resulting-from-granulomatosis-with-polyangiitis-following-treatment-with-rituximab
#2
Grace M Kenny, Konstanze Holl-Ulrich, Timothy Fulcher, Elizabeth McElnea, Eoin Kavanagh, Heather Moriarty, Niall Mulligan, Eamonn S Molloy, Geraldine M McCarthy
Purpose: To report a unique case of orbital inflammatory disease which was ultimately diagnosed as granulomatosis with polyangitis (GPA) and thus successfully treated. Observation: A 47 year-old man presented with a rapidly progressive necrotic soft tissue mass within the medial antero-superior aspect of the right eyelid and orbit. He also had transient retinal vasculitis in the left. Serology, histology and imaging were atypical of, but consistent with, GPA. He was thus successfully treated with intravenous rituximab followed by reconstruction of the medial eyelid...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780922/mri-findings-of-contralateral-oculomotor-nerve-palsy-in-parry-romberg-syndrome
#3
Emily K Tam, Marcela Lonngi, Joseph L Demer
Purpose: To study a case of right Parry Romberg syndrome associated with contralateral oculomotor nerve palsy using high-resolution cerebral and orbital magnetic resonance imaging (MRI). Observations: There were no brain MRI abnormalities. However, there was marked enophthalmos on the right with reduction of orbital fat. Extraocular muscles contracted normally in the right eye, but in the left eye, there was reduced contractility of the medial, inferior, and superior rectus muscles...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780912/orbital-implant-exposure-after-acanthamoeba-panophthalmitis
#4
Meredith S Baker, Amanda C Maltry, Nasreen A Syed, Richard C Allen
Purpose: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. Observations: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780261/orbital-solitary-fibrous-tumor-a-clinicopathologic-study-from-a-chinese-tertiary-hospital-with-a-literature-review
#5
Jianqin Shen, Huiyan Li, Shi Feng, Hongguang Cui
Purpose: To report the clinical features, imaging manifestations, histopathology, and immunohistochemical features of several cases of orbital solitary fibrous tumors (SFTs) in a Chinese tertiary hospital, and to undertake a literature review of this rare disease. Methods: A non-comparative retrospective review of clinical presentations, imaging manifestations, histopathology, and immunohistochemical features as well as the management and disease outcomes of patients with orbital SFT was conducted along with a review of orbital SFT cases in the literature...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29775210/the-effect-of-simulated-space-radiation-on-the-n-glycosylation-of-human-immunoglobulin-g1
#6
Mate Szarka, Szabolcs Szilasi, Boglarka Donczo, Daniel Sarkozy, Istvan Rajta, Andras Guttman
On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amount of radiation that exceeds the lifetime limits on Earth. This elevated radiation dose is mainly due to Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE). Specific patterns of the N-glycosylation of human immunoglobulins have already been associated with various ailments such as autoimmune diseases, malignant transformation, chronic inflammation and ageing. The focus of our work was to investigate the effect of low-energy proton irradiation on the IgG N-glycosylation profile with the goal if disease associated changes could be detected during space travel and not altered by space radiation...
May 18, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29774886/-evaluation-of-inflammatory-activity-in-thyroid-associated-ophthalmopathy-by-spect-ct-with-99mtc-dtpa
#7
Dan Liu, Xueliang Xu, Dan Wen, Jia Tan, Chengzhi Jiang
To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774383/acute-invasive-fungal-rhinosinusitis-mr-imaging-features-and-their-impact-on-prognosis
#8
Ye Ra Choi, Ji-Hoon Kim, Hye Sook Min, Jae-Kyung Won, Hyun Jik Kim, Roh-Eul Yoo, Koung Mi Kang, Sun-Won Park, Tae Jin Yun, Seung Hong Choi, Chul-Ho Sohn, Jung Hyo Rhim, Soo Chin Kim, Jae Wook Ryu, Dong Gyu Na
PURPOSE: Acute invasive fungal rhinosinusitis (AIFRS) is a life-threatening disease that is difficult to diagnose. Its overall imaging features have not been evaluated and the prognostic impact is unclear. The purpose of our study was to present MR imaging features and their impact on prognosis of AIFRS. METHODS: MR images and clinical records of 23 patients with AIFRS were retrospectively evaluated to identify the imaging features and to determine the factors affecting patients' survival...
May 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29773436/non-sinonasal-isolated-facio-orbital-mucormycosis-a-case-report
#9
S K Swain, M C Sahu, A Banerjee
Mucormycosis is a rare clinical entity, often affect immunocompromised patients. It is an emergency situation and has poor prognosis. Prompt diagnosis with tissue biopsy, local control of the disease by aggressive surgical debridement and appropriate systemic antifungal treatment improve the prognosis and survival of the patients. Treatment of mucormycosis needs antifungal agents such as Amphotericin B and wide surgical debridement. Early diagnosis and treatment is often needed for survival of the patients...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29772543/functional-diagnostics-for-thyrotropin-hormone-receptor-autoantibodies-bioassays-prevail-over-binding-assays
#10
Simon David Lytton, Anke Schluter, Paul J Banga
Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29771881/-prediction-of-activity-and-severity-of-endocrine-ophthalmopathy-by-multidimensional-linear-regression-modeling
#11
V G Lihvantseva, M S Afanasev, E A Rudenko, A V Karaulov, S S Afanasev, E V Korosteleva, V A Vygodin
Endocrine ophthalmopathy (EOP) is a severe chronic autoimmune disease associated with autoimmune thyroid pathology that leads to loss of sight, cosmetic defects and quality of life decrease. EOP is difficult to give prognosis for due to various factors affecting its course and outcome. PURPOSE: To develop a reliable and precise prognosis method for EOP activity and severity based on personalized combination of risk factors in specific patients by multidimensional linear regression modeling...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29771752/radiotherapy-for-active-thyroid-eye-disease
#12
Kyle J Godfrey, Michael Kazim
PURPOSE: To critically review the published literature on orbital radiotherapy as a treatment modality for thyroid eye disease (TED). METHODS: A systematic review and analysis of the relevant published literature was performed. RESULTS: Thyroid eye disease is an autoimmune condition that is amenable to treatments that modulate the immune response, including orbital radiotherapy (ORT). Ideal candidates for ORT are patients in the early, active phase of TED with moderate to severe, or rapidly progressive, disease, including patients with significant motility deficits and compressive optic neuropathy...
May 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29765868/retrobulbar-steatitis-and-meningitis-empyema-secondary-to-right-otitis-media-right-otitis-interna-and-an-inflammatory-polyp-in-a-cat
#13
Elena Fenollosa-Romero, Olivier Taeymans, Pieter Nelissen, Giunio B Cherubini, Claudia Busse
The purpose was to describe a case of retrobulbar steatitis and meningitis in a cat caused by otitis media, otitis interna and an inflammatory polyp in the middle ear. Investigations included ophthalmic and neurological examinations, haematology and biochemistry, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and aerobic, anaerobic bacterial and fungal culture of material from the middle ear. A 6-year-old female neutered domestic-short-haired cat presented with right-sided exophthalmos and resistance to retropulsion...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29760827/transcriptome-analysis-of-orbital-adipose-tissue-in-active-thyroid-eye-disease-using-next-generation-rna-sequencing-technology
#14
Bradford W Lee, Virender B Kumar, Pooja Biswas, Audrey C Ko, Ramzi M Alameddine, David B Granet, Radha Ayyagari, Don O Kikkawa, Bobby S Korn
Objective: This study utilized Next Generation Sequencing (NGS) to identify differentially expressed transcripts in orbital adipose tissue from patients with active Thyroid Eye Disease (TED) versus healthy controls. Method: This prospective, case-control study enrolled three patients with severe, active thyroid eye disease undergoing orbital decompression, and three healthy controls undergoing routine eyelid surgery with removal of orbital fat. RNA Sequencing (RNA-Seq) was performed on freshly obtained orbital adipose tissue from study patients to analyze the transcriptome...
2018: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29755273/orbital-progressive-transformation-of-germinal-centers-as-part-of-the-spectrum-of-igg4-related-ophthalmic-disease-clinicopathologic-features-of-three-cases
#15
M Adelita Vizcaino, Shannon S Joseph, Charles G Eberhart
Progressive transformation of germinal centers (PTGC) is a form of follicular hyperplasia recently associated with immunoglobulin G4-related disease (IgG4-RD), but the ophthalmic manifestations of this combination are poorly described. In this retrospective case series, we present three cases of IgG4-related orbital disease (IgG4-ROD) showing varying degrees of PTGC involving the orbit and lacrimal gland. Three adult women presented with ill-defined lacrimal gland enlargement. Histologic sections showed variable fibrosis and large, irregular lymphoid follicles with prominent mantle zones penetrating the germinal centers, highlighted by Bcl-2 and/or IgD immunostains...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755272/langerhans-cell-histiocytosis-in-an-18-month-old-child-presenting-as-periorbital-cellulitis
#16
Andre Ali-Ridha, Seymour Brownstein, Michael O'Connor, Steve Gilberg, Tina Tang
Langerhans cell histiocytosis (LCH) is a rare multi-system disease. It presents infrequently as a childhood orbital tumor, and can mimic more common inflammatory orbital disease processes. We report the clinical, histopathological, and electron microscopic findings of orbital LCH in an 18-month-old child, along with a review of the recent literature regarding molecular pathogenetic analysis of LCH. The child presented with a two-week history of progressive left periorbital edema and redness. He was initially diagnosed and treated empirically for bacterial periorbital cellulitis, but subsequently underwent ophthalmological consultation after he failed to improve...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755270/histiocytic-lesions-of-the-orbit-a-study-of-9-cases
#17
A Kaan Gündüz, Emine Temel
Purpose: To describe the clinical presentation, treatment, and outcome of patients with histiocytic lesions of the orbit. Methods: Retrospective study of 9 patients treated and followed up between October 2001 and January 2018. Results: Eight patients in our series were males and one patient was female. The mean age at presentation was 16.8 years (range, 1 to 42 years). All patients had unilateral disease. The most common presenting complaint was upper eyelid swelling in 8 of 9...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755269/inflammatory-myofibroblastic-tumor-of-the-orbit-a-clinico-pathological-study-of-25-cases
#18
Diego Strianese, Fausto Tranfa, Marialuisa Finelli, Adriana Iuliano, Stefania Staibano, Giuseppe Mariniello
Background: Inflammatory myofibroblastic tumor (IMT) is a rare entity characterized by the presence of myofibroblasts and inflammatory cells within a fibrous stroma, which typically occurs in children or young adults. The IMT is considered generally a benign lesion, although about 20% of cases may experience recurrence, and most rarely develop metastasis. Herein, we present the largest series of primary orbital IMT ever reported. Patients and methods: The clinical records of 25 patients, collected between the 1995 and 2015, with biopsy-proven diagnosis of orbital IMT were retrospectively reviewed to determine demographic, clinical, radiologic and pathological features, management, and outcome...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755267/cognitive-biases-in-orbital-mass-lesions-lessons-learned
#19
Heather M McDonald, James P Farmer, Paula L Blanco
Purpose: A patient's presentation and clinical diagnosis can at times be clouded by their past medical history. Clinicians' anchoring bias towards initial information, such as a history of cancer, may lead them astray when creating a differential diagnosis for a patient who presents with new signs and symptoms of a mass lesion, assuming metastatic disease without seeking tissue confirmation. Methods: The presentation, workup, diagnosis, and treatment of two patients who presented with orbital masses in the context of a primary prostate cancer are presented in this report...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755266/orbital-pathology-iatrogenic-findings-and-artefacts
#20
REVIEW
Caroline Thaung
The relationship between the ophthalmologist and ophthalmic pathologist is particularly important in orbital disease, as diagnosis is heavily dependent on correlation with clinical context. If the patient has previously had treatment to the orbit or an adjacent area, whether for the same or a different condition, tissue changes may occur which affect the histological appearance of any specimen taken. This article is an overview of therapeutic interventions which may cause either orbital pathology or an altered appearance of the tissue, either of which can pose a diagnostic challenge...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
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