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https://www.readbyqxmd.com/read/29155696/safety-of-consecutive-same-day-bilateral-intravitreal-dexamethasone-implant-ozurdex
#1
Kapil G Kapoor, James B Colchao
PURPOSE: The objective of this study was to evaluate patient safety and tolerance of consecutive bilateral intravitreal dexamethasone (Ozurdex) injections during a single visit for the treatment of cystoid macular edema secondary to retinal vein occlusion, diabetic macular edema, or noninfectious posterior uveitis. METHODS: This was a retrospective single-center institutional review board-approved study from March 1, 2013, through August 1, 2016. All patients had a complete ophthalmologic examination and optical coherence tomography imaging...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29155383/efficacy-of-optical-coherence-tomography-derived-morphometric-assessment-in-predicting-the-physiological-significance-of-coronary-stenosis-head-to-head-comparison-with-intravascular-ultrasound
#2
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
AIMS: This study aimed to investigate the diagnostic efficacy of optical coherence tomography (OCT) in identifying functional significance via fractional flow reserve (FFR) compared with that of intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 203 de novo intermediate coronary lesions of 186 patients who underwent frequency-domain OCT, IVUS and FFR measurements. Diagnostic efficacy of the minimal lumen area (MLA) obtained by OCT (OCT-MLA) and IVUS (IVUS-MLA) in predicting an FFR<0...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29155204/reciprocal-contribution-of-clinical-studies-and-the-hp10-antigen-elisa-for-the-diagnosis-of-extraparenchymal-neurocysticercosis
#3
R Michael E Parkhouse, Arturo Carpio, Alfredo Campoverde, Patricia Sastre, Glenda Rojas, María Milagros Cortez
To evaluate diagnosis of active neurocysticercosis, paired cerebral spinal fluid (CSF) and serum samples from 24 neurocysticercosis (NCC) patients and 17 control neurological patients were assayed in the HP10 Taenia antigen (Ag) ELISA. The CSF samples were also tested with an HP10 Lateral Flow Assay (LFA). The HP10 Ag was detected by ELISA in the CSF of 5/5 patients with Definitive extraparenchymal NCC, and in 4/5 of the corresponding sera. In the Definitive parenchymal group, on the other hand, the HP10 Ag was absent in 2/3 CSF (with a very low value in the one positive sample) and all the corresponding serum samples...
November 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29155165/bovine-babesiosis-cattle-protected-in-the-field-with-a-frozen-vaccine-containing-babesia-bovis-and-babesia-bigemina-cultured-in-vitro-with-a-serum-free-medium
#4
Carmen Rojas-Martínez, Roger Iván Rodríguez-Vivas, Julio Vicente Figueroa Millán, Carlos Ramón Bautista-Garfias, Roberto Omar Castañeda-Arriola, José Juan Lira-Amaya, Patricia Vargas Urióstegui, Juan José Ojeda Carrasco, Jesús Antonio Álvarez Martínez
An attenuated live vaccine containing Babesia bovis and B. bigemina cultured in vitro with a serum-free medium was assessed for its clinical protection conferred of naïve cattle, under natural tick-challenge in a high endemicity zone to Babesia spp. Three groups of six animals were treated as follows: group I (GI) received a vaccine derived from parasites cultured with a free-serum medium; group II (GII) were immunized with the standard vaccine, with parasites cultured in a medium supplemented with 40% (v/v) bovine serum; and a control group (GIII) inoculated with non-infected bovine erythrocytes...
November 16, 2017: Parasitology International
https://www.readbyqxmd.com/read/29155113/small-cell-glioblastoma-of-the-sella-turcica-region-a-case-report-and-review-of-the-literature
#5
Shuanglin Deng, Linlin Liu, Danhua Wang, Dan Tong, Gang Zhao
BACKGROUND: Glioblastomas in the sellar region are very rare; in most cases, the tumor originates from the optic nerve/optic chiasm. Only 4 cases of sellar glioblastoma with a non-optic origin have been reported. We present such a case with detailed clinical, imaging and histopathological information. A review of similar published cases is also presented. CASE PRESENTATION: A 42-year-old woman presented with endocrinological abnormalities including, amenorrhea and lactation, symptoms of diabetes insipidus and signs of elevated ICP...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29153502/clinical-outcomes-following-intravascular%C3%A2-imaging-guided-versus-coronary-angiography-guided-percutaneous-coronary-intervention-with%C3%A2-stent-implantation-a%C3%A2-systematic-review-and-bayesian-network-meta-analysis-of%C3%A2-31%C3%A2-studies-and-17-882-patients
#6
Sergio Buccheri, Gabriele Franchina, Sara Romano, Sebastiano Puglisi, Giuseppe Venuti, Paolo D'Arrigo, Bruno Francaviglia, Matteo Scalia, Antonio Condorelli, Marco Barbanti, Piera Capranzano, Corrado Tamburino, Davide Capodanno
OBJECTIVES: The authors sought to explore the comparative clinical efficacy of different imaging modalities for guiding percutaneous coronary interventions (PCI). BACKGROUND: Coronary angiography (CA) is the standard imaging modality for intraprocedural guidance of PCI. Intracoronary imaging techniques, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), can overcome some limitations of CA. METHODS: Comprehensive hierarchical Bayesian network meta-analysis of randomized clinical trials and adjusted observational studies comparing clinical outcomes of PCI with stent implantation guided by CA, IVUS, or OCT...
November 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29153070/-the-importance-of-the-contribution-of-rapid-test-serological-and-molecular-methods-in-the-diagnosis-of-two-imported-malaria-cases-with-atypical-microscopy
#7
Orçun Zorbozan, Hüsnü Pullukçu, Esra Atalay Şahar, Muhammet Karakavuk, Hüseyin Can, Varol Tunali, Mert Döşkaya, Nevin Turgay, Seray Töz, Ahmet Özbilgin
Malaria is a widespread and life-threatening disease in tropical and subtropical regions. In patients with typical clinical symptoms, malaria is considered as a preliminary diagnosis if there is a travel history to malaria-endemic areas. The basis of the laboratory diagnosis of malaria is the microscopic examination of Giemsa stained smears. On the other hand, the diagnosis and differentiation of Plasmodium species with microscopic examination may have some difficulties. In the first case, adifferent appearance from the classical Plasmodium vivax erythrocytic forms in infected erythrocytes were detected in 1% of all erythrocytes in thin smear blood preparations of a 26-year-old male with complaints of fever and chills and a story of travel to Nigeria...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29151470/-polymer-gel-dosimeter
#8
Shin-Ichiro Hayashi
With rapid advances being made in radiotherapy treatment, three-dimensional (3D) dose measurement techniques of great precision are required more than ever before. It is expected that 3D polymer gel dosimeters will satisfy clinical needs for an effective detector that can measure the complex 3D dose distributions. Polymer gel dosimeters are devices that utilize the radiation-induced polymerization reactions of vinyl monomers in a gel to store information about radiation dose. The 3D absorbed dose distribution can be deduced from the resulting polymer distribution using several imaging modalities, such as MRI, X-ray and optical CTs...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/29151138/optical-coherence-tomography-guided-percutaneous-coronary-intervention-compared-with-other-imaging-guidance-a-meta-analysis
#9
Kayode O Kuku, Emmanuel Ekanem, Viana Azizi, Gebremedhin Melaku, Anh Bui, Yael F Meirovich, Aaphtaab Dheendsa, Solomon Beyene, Alexandre Hideo-Kajita, Michael J Lipinski, Ron Waksman, Hector M Garcia-Garcia
The use of optical coherence tomography (OCT) in PCI guidance is limited perhaps by the lack of adequately powered studies which compare its efficacy and outcomes to the other more popular imaging modalities. We therefore performed a meta-analysis to compare clinical outcomes following OCT-guided PCI with the other imaging modalities in two separate comparisons. We abstracted data from randomized control trials and observational comparative studies focusing on OCT versus either angiography- or IVUS-guided PCI outcomes identified following a systematic search (April 2006 and May 2017)...
November 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29150681/the-structure-function-relationship-measured-with-optical-coherence-tomography-and-a-microperimeter-with-auto-tracking-the-mp-3-in-patients-with-retinitis-pigmentosa
#10
Yuichi Asahina, Marie Kitano, Yohei Hashimoto, Mieko Yanagisawa, Hiroshi Murata, Tatsuya Inoue, Ryo Obata, Ryo Asaoka
The purpose of the current study was to investigate the structure-function relationship in patients with retinitis pigmentosa (RP) using optical coherence tomography and the MP-3 microperimeter. Visual field (VF) measurements were carried out using MP-3 microperimetry and the Humphrey Field Analyzer (HFA, Carl-Zeiss, CA), 22 eyes of 11 patients with a clinical diagnosis of RP, both with the 10-2 test grid pattern. Optical coherence tomography (OCT, Spectralis, Heidelberg, Germany) was also performed and the ellipsoid zone (EZ) was identified in the OCT image...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#11
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29150135/effect-of-different-resin-luting-cements-on-the-marginal-fit-of-lithium-disilicate-pressed-crowns
#12
Radek Mounajjed, Thomas J Salinas, Tomas Ingr, Basel Azar
STATEMENT OF PROBLEM: The vertical marginal discrepancy of restorations can increase upon cementation, and poor marginal fit can lead to cement dissolution, marginal discoloration, microleakage, and secondary caries. The amount of increase is related to the type of luting cement used, but how lithium disilicate pressed crowns are affected by different resin cements is unclear. PURPOSE: The purpose of this in vitro study was to compare the effect of using different resin luting cements on the vertical marginal discrepancy of lithium disilicate pressed crowns...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29149320/organic-scintillator-for-real-time-neutron-dosimetry
#13
Kyle A Beyer, Angela Di Fulvio, Liliana Stolarczyk, Wiktor Parol, Natalia Mojzeszek, Renata Kopéc, Shaun D Clarke, Sara A Pozzi
We developed a radiation detector based on an organic scintillator for spectrometry and dosimetry of out-of-field secondary neutrons from clinical proton beams. The detector consists of an EJ-299-34 crystalline organic scintillator, coupled by fiber optic cable to a silicon photomultiplier (SiPM). Proof of concept measurements were taken with 137Cs and 252Cf, and corresponding simulations were performed in MCNPX-PoliMi. Despite its small size, the detector is able to discriminate between neutron and gamma-rays via pulse shape discrimination...
November 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29149239/label-free-in-vivo-imaging-of-corneal-lymphatic-vessels-using-microscopic-optical-coherence-tomography
#14
Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods: Corneal neovascularization was induced by intrastromal placement of 11...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29149211/occupational-exposure-to-unburnt-tobacco-and-potential-risk-of-toxic-optic-neuropathy-a-cross-sectional-study-among-beedi-rollers-in-selected-rural-areas-of-coastal-karnataka-india
#15
Soujanya Kaup, Ansaba Naseer, Siddharudha Shivalli, Cynthia Arunachalam
BACKGROUND: Beedi also known as poor man's cigarette is manufactured in almost all major states of India. Beedi workers are exposed to various health risks. There is an increased risk of systemic absorption of tobacco through skin and mucous membrane. The optic nerve is susceptible to damage from several toxic substances including tobacco. This group of disorders is known as toxic optic neuropathy (TON). The association of TON with occupational exposure to unburnt tobacco in beedi rollers has not been explored...
2017: PloS One
https://www.readbyqxmd.com/read/29148965/nonclinical-safety-assessment-of-anti-factor-d-key-strategies-and-challenges-for-the-nonclinical-development-of-intravitreal-biologics
#16
Vladimir Bantseev, Rebecca Erickson, Douglas Leipold, Caroline Amaya, Paul E Miller, Helen Booler, Evan A Thackaberry
PURPOSE: The nonclinical toxicology program described here was designed to characterize the safety profile of anti-factor D (AFD; FCFD4514S, lampalizumab) to support intravitreal (ITV) administration in patients with geographic atrophy (GA). METHODS: The toxicity of AFD was assessed in a single-dose and 6-month repeat-dose study in monkeys at doses up to 10 mg/eye. Toxicity was assessed by clinical ophthalmic examinations, intraocular pressure measurements, ocular photography, electroretinography, fluorescein angiography, optical coherence tomography, and anatomic pathology...
November 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29148864/morphologic-criteria-of-lesion-activity-in-neovascular-age-related-macular-degeneration-a-consensus-article
#17
Stefania Miotto, Nicola Zemella, Elena Gusson, Giacomo Panozzo, Sandro Saviano, Giuseppe Scarpa, Giorgio Boschi, Stefano Piermarocchi
Intravitreal antivascular endothelial growth factor drugs represent the current standard of care for neovascular age-related macular degeneration (nAMD). Individualized treatment regimens aim at obtaining the same visual benefits of monthly injections with a reduced number of injections and follow-up visits, and, consequently, of treatment burden. The target of these strategies is to timely recognize lesion recurrence, even before visual deterioration. Early detection of lesion activity is critical to ensure that clinical outcomes are not compromised by inappropriate delays in treatment, but questions remain on how to effectively monitor the choroidal neovascularization (CNV) activity...
November 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29148536/characterization-of-foreign-materials-in-paraffin-embedded-pathological-specimens-using-in-situ-multi-elemental-imaging-with-laser-spectroscopy
#18
Benoit Busser, Samuel Moncayo, Florian Trichard, Vincent Bonneterre, Nicole Pinel, Frédéric Pelascini, Philippe Dugourd, Jean-Luc Coll, Michel D'Incan, Julie Charles, Vincent Motto-Ros, Lucie Sancey
Pathologists typically encounter many disparate exogenous materials in clinical specimens during their routine histopathological examinations, especially within the skin, lymph nodes, and lungs. These foreign substances may be free extracellular deposits or induce several clinical abnormalities or histopathological patterns. However, pathologists almost never investigate or report the chemical nature of exogenous metals in clinical specimens due to a lack of convenient and available technologies. In this paper, a novel strategy based on laser-induced breakdown spectroscopy (LIBS) technology is evaluated for in situ multi-elemental tissue imaging...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29148533/identifying-characteristic-features-of-the-retinal-and-choroidal-vasculature-in-choroideremia-using-optical-coherence-tomography-angiography
#19
A Abbouda, A M Dubis, A R Webster, M Moosajee
PurposeUsing optical coherence tomography angiography (OCTA) to investigate the area with flow in the superficial retinal vessel network (SVRN) and choriocapillaris (CC) layer among male subjects with choroideremia (CHM), female carriers, and normal controls to identify vascular changes.Patients and methodsImages of SRVN and CC layer were acquired in 9 affected males, 5 female carriers, and 14 age- and gender-matched controls using the Angiovue software of the RTVue XR Avanti.ResultsThe mean age was 33 years for affected male CHM patients (median 30 years), 46 years for female carriers (median 53 years), and 39 years for controls (median 38...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148525/differences-in-photoreceptor-recovery-among-patients-and-between-different-parts-of-the-posterior-pole-in-vogt-koyanagi-harada-disease
#20
M Zhou, R P Gu, Z Sun, C H Jiang, Q Chang, G Z Xu
PurposeTo investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease.Patients and methodsThis was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery...
November 17, 2017: Eye
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