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https://www.readbyqxmd.com/read/28938379/dark-endothelial-spots-after-descemet-membrane-endothelial-keratoplasty-may-appear-as-recurrent-fuchs-dystrophy-or-herald-graft-failure-or-rejection
#1
Vasiliki Zygoura, Lamis Baydoun, Claire Monnereau, Maria Satué, Silke Oellerich, Gerrit R J Melles
PURPOSE: To evaluate the clinical significance of dark spots in the donor endothelial cell layer as observed with specular microscopy, in patients who underwent Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: Specular microscopy images of 83 consecutive eyes up to 7 years after DMEK were retrospectively reviewed in a masked fashion for the presence of dark spots and morphologic changes in the endothelial cell layer and processed for endothelial cell density (ECD) measurements...
September 21, 2017: Cornea
https://www.readbyqxmd.com/read/28937828/the-effects-of-systemic-alfuzosin-and-tamsulosin-hydrochloride-on-choroidal-thickness-and-pupil-diameter-sizes-in-cases-with-benign-prostatic-hyperplasia
#2
Mustafa Dogan, Bunyamin Kutluksaman, Ibrahim Keles, Mustafa Karalar, Ahmet Omer Halat
PURPOSE: To compare the effects of alfuzosin hydrochloride and tamsulosin hydrochloride on choroidal thickness (CT) and pupil diameter (PD) sizes in patients with benign prostatic hyperplasia. SUBJECTS AND METHODS: Sixty-three men patients with newly diagnosis of benign prostatic hyperplasia were randomly assigned to either alfuzosin hydrochloride or to tamsulosin hydrochloride groups in this prospective, randomized, parallel-group clinical trial. Enhanced depth imaging spectral-domain optical coherence tomography, pupillography were obtained at baseline, 1st and 3rd month, and choroidal thicknesses and pupil diameter sizes were compared between the two groups...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937528/long-term-follow-up-of-patients-with-choroideremia-with-scleral-pits-and-tunnels-as-a-novel-observation
#3
Sanne M van Schuppen, Mays Talib, Arthur A Bergen, Jacoline B Ten Brink, Ralph J Florijn, Camiel J F Boon, Mary J van Schooneveld
PURPOSE: To evaluate the long-term clinical course and visual outcome of patients with choroideremia. METHODS: Clinical examination, a social questionnaire, and medical records review of 21 patients with choroideremia from 14 families. RESULTS: The mean follow-up time was 25.2 years (SD: 13.3; range 2-57 years). The mean age at symptom onset was 15.1 years (SD: 10.1; range 5-40 years). Best-corrected visual acuity was stable until the age of 35 (P = 0...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28937524/self-inflicted-laser-handheld-laser-induced-maculopathy-a-novel-ocular-manifestation-of-factitious-disorder
#4
Alessandro Rabiolo, Riccardo Sacconi, Chiara Giuffrè, Eleonora Corbelli, Adriano Carnevali, Lea Querques, David Sarraf, K Bailey Freund, SriniVas Sadda, Francesco Bandello, Giuseppe Querques
PURPOSE: To report a case of factitious self-inflicted handheld laser-induced maculopathy. METHODS: A 29-year-old man presented to our clinic complaining of a step-wise progressive loss of vision that abruptly began in his left eye but then became bilateral. He underwent comprehensive ocular examination, including visual acuity testing, biomicroscopic, dilated funduscopic examination, structural optical coherence tomography, en face structural optical coherence tomography, optical coherence tomography angiography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography...
September 19, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28937496/characterizing-intraorbital-optic-nerve-changes-on-diffusion-tensor-imaging-in-thyroid-eye-disease-before-dysthyroid-optic-neuropathy
#5
Hwa Lee, Young Hen Lee, Sang-Il Suh, Eun-Kee Jeong, Sehyun Baek, Hyung Suk Seo
OBJECTIVE: The aim of this study was to determine whether the optic nerve is affected by thyroid eye disease (TED) before the development of dysthyroid optic neuropathy with diffusion-tensor imaging (DTI). METHODS: Twenty TED patients and 20 controls were included. The mean, axial, and radial diffusivities and fractional anisotropy (FA) value were measured at the optic nerves in DTI. Extraocular muscle diameters were measured on computed tomography. The diffusivities and FA of the optic nerves were compared between TED and controls and between active and inactive stages of TED...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937488/the-significance-of-arachnoid-granulation-in-patients-with-idiopathic-intracranial-hypertension
#6
Gaurav Vishwasrao Watane, Bhumi Patel, Derek Brown, M Reza Taheri
PURPOSE: The aim of this article was to study the significance of arachnoid granulations (AGs) in patients with idiopathic intracranial hypertension (IIH). METHODS: In an institutional review board-approved retrospective chart review study, 79 patients with clinical diagnosis of idiopathic increased intracranial pressure were compared with 63 patients with a diagnosis of multiple sclerosis. Inclusion criteria also included available magnetic resonance imaging (MRI) of the brain, older than 18 years, and female sex...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28936540/-chondral-and-osteochondral-defects-representation-by-imaging-methods
#7
REVIEW
S Nebelung, B Rath, M Tingart, C Kuhl, S Schrading
Morphological imaging of cartilage at high resolution allows the differentiation of chondral and osteochondral lesions. Nowadays, magnetic resonance imaging is the principal diagnostic tool in the assessment of cartilage structure and composition. Conventional radiography, computed tomography, ultrasound or optical coherence tomography are adjunct diagnostic modalities in the assessment of cartilage pathologies. The present article discusses the up-to-date diagnostic practice of cartilage imaging in terms of its scientific basis and current clinical status, requirements, techniques and image interpretation...
September 21, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28935968/electrophysiological-studies-in-thyroid-associated-orbitopathy-a-systematic-review
#8
Tiara W U Iao, Shi Song Rong, An Ni Ling, Mårten E Brelén, Alvin Lerrmann Young, Kelvin K L Chong
Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935833/how-to-use%C3%A2-the-direct-ophthalmoscope
#9
Sam P Gurney, Taiwo Makanjuola, Muhammad Kutubi, Manoj Parulekar, Joseph Abbott
Ophthalmoscopy and red reflex examination are core medical skills required to identify sight-threatening and life-threatening disease. We discuss the predictive utility and limitations of findings with an ophthalmoscope and tips as to how to optimise these. We outline important considerations in three clinical scenarios: an abnormal red reflex, an abnormal optic disc and retinal haemorrhages in the context of child protection concerns.
September 21, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28935527/axis-free-correction-of-astigmatism-using-bifocal-soft-contact-lenses
#10
Alexander Leube, Imre Kovats, Siegfried Wahl, Wolfgang Sickenberger
PURPOSE: Pilot study to investigate the feasibility of an axis-free correction approach of regular astigmatism using soft, bifocal contact lenses (CL). METHODS: The investigation covers an optical simulation and a pilot study for the assessment of visual performance (over refraction OR, monocular visual acuity VA). The power of the two zones was adjusted according to the power of the astigmatic meridians, individually. Subjective performance was assessed in 30 participants with a mean horizontal cylindrical component of J0=- 0...
September 18, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28935079/effect-of-post-dilatation-following-primary-pci-with-everolimus-eluting-bioresorbable-scaffold-versus-everolimus-eluting-metallic-stent-implantation-an-angiographic-and-optical-coherence-tomography-trofi%C3%A2-ii%C3%A2-substudy
#11
Kyohei Yamaji, Salvatore Brugaletta, Manel Sabaté, Andrés Iñiguez, Lisette Okkels Jensen, Angel Cequier, Sjoerd H Hofma, Evald Høj Christiansen, Maarten Suttorp, Gerrit Anne van Es, Yohei Sotomi, Yoshinobu Onuma, Patrick W Serruys, Stephan Windecker, Lorenz Räber
OBJECTIVES: This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EES). BACKGROUND: Routine post-dilatation of BRS has been suggested to improve post-procedural angiographic and subsequent device-related clinical outcomes. METHODS: In the ABSORB STEMI TROFI II trial, 191 patients with ST-segment elevation myocardial infarction were randomly assigned to treatment with BRS (n = 95) or EES (n = 96)...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28935073/incidence-clinical-presentation-and-predictors-of-clinical-restenosis-in-coronary-bioresorbable-scaffolds
#12
Alberto Polimeni, Melissa Weissner, Katharina Schochlow, Helen Ullrich, Ciro Indolfi, Jouke Dijkstra, Remzi Anadol, Thomas Münzel, Tommaso Gori
OBJECTIVES: The aim of this study was to describe the incidence and clinical characteristics, including intracoronary imaging features, of clinical restenosis in bioresorbable coronary scaffolds (BRS). Further, the authors searched for clinical and procedural predictors of scaffold restenosis (ScR) and report on the clinical outcomes after treatment of ScR in a cohort of consecutive all-comer patients. BACKGROUND: Data from randomized controlled trials demonstrate a higher rate of target lesion failure in patients treated with BRS as compared with those treated with metal drug-eluting stents...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28934871/idiopathic-intracranial-hypertension-vision-venous-intervention-versus-shunting-in-iih-for-optic-nerve-disc-swelling-trial-patient-perspective-questionnaire
#13
Arun Chandran, Heinke Pulhorn, Catherine McMahon
INTRODUCTION: Headaches, visual problems and tinnitus are symptoms of Idiopathic Intracranial Hypertension (IIH) which resolve with reduction of CSF pressure. Impaired cranial venous outflow has been implicated in the pathogenesis and there is evidence of good treatment results in IIH using venous sinus stenting. We are currently initiating a multi-centre randomised controlled trial, the VISION study (Venous Intervention versus Shunting in IIH for Optic Disc Swelling) comparing radiological (venous sinus stenting) to surgical intervention (CSF shunting)...
September 21, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28934247/the-extent-of-intrauterine-growth-restriction-determines-the-severity-of-cerebral-injury-and-neurobehavioural-deficits-in-rodents
#14
Crystal A Ruff, Stuart D Faulkner, Prakasham Rumajogee, Stephanie Beldick, Warren Foltz, Jennifer Corrigan, Alfred Basilious, Shangjun Jiang, Shanojan Thiyagalingam, Jerome Y Yager, Michael G Fehlings
BACKGROUND: Cerebral Palsy (CP) is the most common physical pediatric neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP results in substantial neuromotor and cognitive impairments that have significant socioeconomic impact. Despite this, its underlying pathophysiological mechanisms and etiology remain incompletely understood. Furthermore, there is a need for clinically relevant injury models, which a) reflect the heterogeneity of the condition and b) can be used to evaluate new translational therapies...
2017: PloS One
https://www.readbyqxmd.com/read/28933353/technical-solutions-for-simultaneous-meg-and-seeg-recordings-towards-routine-clinical-use
#15
J M Badier, A S Dubarry, M Gavaret, S Chen, A S Trébuchon, P Marquis, J Régis, F Bartolomei, C G Bénar, R Carron
OBJECTIVE: The simultaneous recording of intracerebral EEG (stereotaxic EEG, SEEG) and magnetoencephalography (MEG) is a promising strategy that provides both local and global views on brain pathological activity. Yet, acquiring simultaneous signals poses difficult technical issues that hamper their use in clinical routine. Our objective was thus to develop a set of solutions for recording a high number of SEEG channels while preserving signal quality. APPROACH: We recorded data in a patient with drug resistant epilepsy during presurgical evaluation...
September 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28933233/optical-coherence-tomography-angiography-retinal-vascular-network-assessment-in-multiple-sclerosis
#16
Roberta Lanzillo, Gilda Cennamo, Chiara Criscuolo, Antonio Carotenuto, Nunzio Velotti, Federica Sparnelli, Alessandra Cianflone, Marcello Moccia, Vincenzo Brescia Morra
BACKGROUND: Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. OBJECTIVE: To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features. METHODS: A total of 50 MS patients with and without history of optic neuritis (ON) and 46 healthy subjects were included...
September 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28932684/value-of-combining-dynamic-contrast-enhanced-ultrasound-and-optoacoustic-tomography-for-hypoxia-imaging
#17
Anant Shah, Nigel Bush, Gary Box, Suzanne Eccles, Jeffrey Bamber
Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion...
December 2017: Photoacoustics
https://www.readbyqxmd.com/read/28932609/neuromyelitis-optica-in-a-nepalese-man
#18
Yogesh Subedi, Utsav Joshi, Sanjeeb Sudarshan Bhandari, Ashbina Pokharel, Ashbita Pokharel
BACKGROUND: Neuromyelitis optica is a severely disabling inflammatory disorder of the central nervous system of autoimmune etiology that mainly affects the optic nerves and spinal cord. Here, we present a case report detailing a patient with tingling and weakness of right upper and lower limbs who was neuromyelitis optica immunoglobulin G-positive. CASE PRESENTATION: A 46-year-old Nepalese man presented to the hospital with a history of tingling and weakness of right upper and lower limbs that developed over a period of two months...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28932410/quantitative-characterization-of-optic-nerve-atrophy-in-patients-with-multiple-sclerosis
#19
Robert L Harrigan, Alex K Smith, Bailey Lyttle, Bailey Box, Bennett A Landman, Francesca Bagnato, Siddharama Pawate, Seth A Smith
BACKGROUND: Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation. OBJECTIVE: The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#20
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
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