keyword
MENU ▼
Read by QxMD icon Read
search

ocular surface

keyword
https://www.readbyqxmd.com/read/27911424/-effectiveness-of-soft-contact-lenses-in-severe-keratoconjunctivitis-sicca-treated-with-local-immunosuppressive-therapy
#1
T N Safonova, O V Gladkova, V I Boev, A A Fedorov
AIM: To study the effectiveness of soft contact lenses in severe keratoconjunctivitis sicca (KCS) treated with local immunosuppressive therapy. MATERIAL AND METHODS: We have examined 41 patients (60 eyes) with severe KCS, including 3 men (4 eyes) and 38 women (56 eyes) aged from 27 to 76 years. Group 1 consisted of 22 persons (30 eyes) who were prescribed cyclosporine А 0.05% instillations 2 times daily, artificial tears, and soft contact lenses. Group 2 consisted of 19 patients (30 eyes) who received instillations of cyclosporine А 0...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27906544/lfa-1-icam-1-interaction-as-a-therapeutic-target-in-dry-eye-disease
#2
Stephen C Pflugfelder, Michael Stern, Steven Zhang, Amir Shojaei
Dry eye disease (DED) is a common ocular disorder associated with inflammation of the lacrimal gland and ocular surface. The interaction of the integrin lymphocyte function-associated antigen-1 (LFA-1) with its cognate ligand intercellular adhesion molecule-1 (ICAM-1) is known to have important roles in the interaction of a variety of cells involved in immune responses and inflammation, including those prominent in ocular surface inflammation. Lifitegrast, an LFA-1 antagonist that blocks binding of ICAM-1 to LFA-1, has recently been approved in the United States for the treatment of signs and symptoms of DED...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27905329/recombinant-interferon-alpha-2b-for-ocular-surface-squamous-neoplasia-an-efficient-and-cost-effective-treatment-modality-in-asian-indian-patients
#3
Swathi Kaliki, Swati Singh, Sadiya Iram, Dharani Tripuraneni
PURPOSE: The purpose was to study the efficacy of interferon alpha 2b (INF α2b) in the treatment of ocular surface squamous neoplasia (OSSN) and analyze its cost-effectiveness in India. STUDY DESIGN: This was a retrospective study of thirty patients with OSSN treated with topical INF α2b (1 MIU/cc) ± perilesional INF α2b (5 MIU/cc). RESULTS: The tumor involved cornea (n = 9, 30%), conjunctivo-limbal-corneal surface (n = 19, 63%), or bulbar conjunctiva (n = 2, 7%)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902781/correction-influence-of-light-emitting-diode-derived-blue-light-overexposure-on-mouse-ocular-surface
#4
Hyo Seok Lee, Lian Cui, Ying Li, Ji Suk Choi, Joo-Hee Choi, Zhengri Li, Ga Eon Kim, Won Choi, Kyung Chul Yoon
[This corrects the article DOI: 10.1371/journal.pone.0161041.].
2016: PloS One
https://www.readbyqxmd.com/read/27898730/plasma-lipid-profiling-of-patients-with-chronic-ocular-complications-caused-by-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#5
Kosuke Saito, Mayumi Ueta, Keiko Maekawa, Chie Sotozono, Shigeru Kinoshita, Yoshiro Saito
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology of chronic SOCs. Because plasma lipid profiling has emerged as a useful tool to understand pathophysiological alterations in the body, we performed plasma lipid profiling of 17 patients who suffered from SJS/TEN-associated chronic SOCs...
2016: PloS One
https://www.readbyqxmd.com/read/27898615/the-role-of-confocal-microscopy-in-diagnosing-ocular-surface-tumors
#6
Sarah Tanaka, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27898614/human-papilloma-virus-vaccination-and-incidence-of-ocular-surface-squamous-neoplasia
#7
Joy N Carroll, Zachary I Willis, Annabelle de St Maurice, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27896533/characteristics-of-higher-order-aberrations-and-anterior-segment-tomography-in-patients-with-pathologic-myopia
#8
Kaori Kasahara, Naoyuki Maeda, Takashi Fujikado, Makoto Tomita, Muka Moriyama, Mutsumi Fuchihata, Kyoko Ohno-Matsui
PURPOSE: To investigate prospectively the characteristics in the higher-order aberrations and anterior segment tomography in patients with pathologic myopia. METHODS: One hundred and twelve consecutive highly myopic patients (mean age 43.4 ± 9.3 years, spherical equivalent of refractive error ≥8 D and an axial length ≥26.5 mm) were studied. Thirty-seven emmetropic individuals (mean age 37.0 ± 14.5 years, spherical equivalent of refractive error ≤ ±1 D) were analyzed as controls...
November 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27893585/conjunctival-melanoma-responsive-to-combined-systemic-braf-mek-inhibitors
#9
Lora R Dagi Glass, Donald P Lawrence, Frederick A Jakobiec, Suzanne K Freitag
This report demonstrates a unique case of conjunctival melanoma harboring a BRAF V600E mutation responsive to systemic therapy with BRAF and MEK inhibitors. While systemic therapy would not be appropriate in patients with local disease alone, it may act therapeutically in cases of higher stage ocular surface and eyelid melanoma.
November 23, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27893522/zone-i-of-tear-microdesiccates-is-a-lipid-containing-structure
#10
Felipe Traipe, Leonidas Traipe, Daniela Salinas-Toro, Daniela López, Felipe Valenzuela, Claudio Pérez, Cristian Cartes, Francisca Zuazo, Patricia Varela, Héctor Toledo-Araya, Remigio López-Solís
PURPOSE: Morphological features of tear microdesiccates on glass surfaces have been associated with tear fluid status. Tear-film lipids play a critical role in the pathophysiology of some ocular surface disorders. Tear microdesiccates display 4 distinctive morphological domains (zones I, II, III, and transition band). In this study, we investigated the lipid location in tear microdesiccates. METHODS: Tear from individual healthy eyes (assessed by symptoms, signs, and slit-lamp examination) was collected using absorbing minisponges...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27893109/safety-and-efficacy-clinical-trials-for-syl1001-a-novel-short-interfering-rna-for-the-treatment-of-dry-eye-disease
#11
José Manuel Benitez-Del-Castillo, Javier Moreno-Montañés, Ignacio Jiménez-Alfaro, Francisco José Muñoz-Negrete, Krista Turman, Kadi Palumaa, Belén Sádaba, María Victoria González, Verónica Ruz, Beatriz Vargas, Covadonga Pañeda, Tamara Martínez, Anne-Marie Bleau, Ana Isabel Jimenez
Purpose: To evaluate the efficacy and safety of SYL1001, a short interfering (si) RNA targeting the transient receptor potential cation channel subfamily V member 1 (TRPV1), for the treatment of dry eye disease (DED). Methods: This study combines a phase I and two phase II clinical trials to test different doses of SYL1001 in a total of 156 healthy subjects and patients with DED. After 10 days of treatment, the primary efficacy endpoints were the effect on (1) the scoring in the Visual Analogue Scale (VAS) and Ocular Surface Disease Index (OSDI) questionnaires, and (2) ocular tolerance evaluated by corneal fluorescein staining and conjunctival hyperemia...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893066/symptoms-and-satisfaction-of-patients-in-the-patient-reported-outcomes-with-laser-in-situ-keratomileusis-prowl-studies
#12
Malvina Eydelman, Gene Hilmantel, Michelle E Tarver, Elizabeth M Hofmeister, Jeanine May, Keri Hammel, Ron D Hays, Frederick Ferris
Importance: Patient-reported outcomes should be collected using validated questionnaires prior to and following laser in situ keratomileusis (LASIK) surgery. Objective: To report the frequency of patient-reported visual symptoms, dry eye symptoms, satisfaction with vision, and satisfaction with LASIK surgery in the Patient-Reported Outcomes With LASIK (PROWL) studies. Design, Setting, and Participants: The PROWL-1 and PROWL-2 studies were prospective, observational studies conducted from September 13, 2011, to June 27, 2014...
November 23, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27893063/assessment-of-the-psychometric-properties-of-a-questionnaire-assessing-patient-reported-outcomes-with-laser-in-situ-keratomileusis-prowl
#13
Ron D Hays, Michelle E Tarver, Karen L Spritzer, Steve Reise, Gene Hilmantel, Elizabeth M Hofmeister, Keri Hammel, Jeanine May, Frederick Ferris, Malvina Eydelman
Importance: Patient-reported outcome (PRO) measures for laser in situ keratomileusis (LASIK) are needed. Objective: To develop PRO measures to assess satisfaction, eye-related symptoms, and their effect on functioning and well-being following LASIK based on patient and expert input. Design, Setting, and Participants: The Patient-Reported Outcomes With LASIK (PROWL) studies were prospective observational studies of patients undergoing LASIK surgery for myopia, hyperopia, or astigmatism...
November 23, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27892757/basic-principles-and-current-status-of-transcorneal-and-transscleral-iontophoresis
#14
Taís Gratieri, Verena Santer, Yogeshvar N Kalia
Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted topical therapy of intracorneal diseases, whereas transscleral iontophoresis may enable non-invasive intraocular drug delivery. Areas covered: We describe iontophoretic principles in the context of ocular delivery before providing a summary of recent preclinical studies involving transcorneal and transscleral iontophoresis in vitro and in vivo...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892479/evaluation-of-the-effects-of-conjunctivochalasis-excision-on-tear-stability-and-contrast-sensitivity
#15
Weiqiang Qiu, Mingzhou Zhang, Ting Xu, Ziyuan Liu, Huibin Lv, Wei Wang, Xuemin Li
Conjunctivochalasis (CCh) disrupts tear flow and damages tear film stability. This study sought to evaluate the tear stability and contrast sensitivity of patients with CCh on whom CCh excision was performed. The study included 39 eyes from 39 patients; all patients had eyes with grade 2 or 3 CCh, underwent CCh excision, and were evaluated before and three months after the surgery. The evaluated variables included the ocular surface disease index (OSDI), the tear break-up time (TBUT), corneal fluorescein staining, corneal surface irregularity, Schirmer's I test, the tear meniscus area (TMA), and contrast sensitivity...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891360/why-should-viral-markers-be-mandatory-in-ocular-surgeries-a-hospital-based-retrospective-study
#16
Anita Ambastha, Rakhi Kusumesh, Gyan Bhasker
INTRODUCTION: Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus I, II (HIV-I,II) are serious global and public health problem. Knowledge of the seroprevalence would enable early diagnosis, treatment of patients and also help in prevention of horizontal spread of infection by application of universal infection control measures. AIM: To determine the seroprevalence of HBV, HCV and HIV I, II infection in patients undergoing ocular surgery...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888184/amnion-assisted-conjunctival-epithelial-redirection-in-limbal-stem-cell-grafting
#17
Harminder S Dua, Ammar Miri, Mohamed S Elalfy, Anna Lencova, Dalia G Said
AIMS: To develop a technique using amniotic membrane (AM) to prevent admixture of conjunctival epithelial cells and limbal explant-derived corneal epithelial cells in patients undergoing limbal stem cell transplantation. To compare this technique with the current method of 'sequential sector conjunctival epitheliectomy' (SSCE). METHODS: 26 patients with total limbal stem cell deficiency who underwent ocular surface reconstruction with limbal stem cells transplantation were retrospectively studied...
November 25, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27883115/lifitegrast-first-lfa-1-icam-1-antagonist-for-treatment-of-dry-eye-disease
#18
D M Paton
Dry eye disease is an extremely common condition affecting millions worldwide. The underlying pathophysiological mechanism is thought to be localized inflammation of the ocular surface resulting in the localization of T cells at this surface followed by their activation and subsequent liberation of cytokines. This effect on T cells results from the binding of lymphocyte function-associated antigen-1 (LFA-1) located on T cells to intercellular adhesion molecule 1 (ICAM-1) expressed on inflamed epithelium and endothelium, and on T cells...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27881591/vernal-keratoconjunctivitis-culmination-of-management-using-immunosuppression-surgical-and-prosthetic-therapy-over-quarter-century
#19
Shilpa Das, Anand S Pasari, Virender S Sangwan
A 22-year-old male patient presented in 1988 with active vernal keratoconjunctivitis. He was treated with topical mast cell stabilisers and corticosteroids. Chronic inflammation despite topical treatment necessitated oral immunosuppressants. Active disease came under control with this; however, the patient gradually developed limbal stem cell deficiency. He underwent bilateral pannus resection with amniotic membrane transplantation that resulted in improved ocular surface. In 2007, patient was found to have significant bilateral posterior subcapsular cataracts and underwent bilateral cataract surgery with intraocular lens implantation with good visual outcome...
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27876873/the-effect-of-silica-nanoparticles-on-human-corneal-epithelial-cells
#20
Joo-Hee Park, Hyejoong Jeong, Jinkee Hong, Minwook Chang, Martha Kim, Roy S Chuck, Jimmy K Lee, Choul-Yong Park
Ocular drug delivery is an interesting field in current research. Silica nanoparticles (SiNPs) are promising drug carriers for ophthalmic drug delivery. However, little is known about the toxicity of SiNPs on ocular surface cells such as human corneal epithelial cells (HCECs). In this study, we evaluated the cytotoxicity induced by 50, 100 and 150 nm sizes of SiNPs on cultured HCECs for up to 48 hours. SiNPs were up-taken by HCECs inside cytoplasmic vacuoles. Cellular reactive oxygen species generation was mildly elevated, dose dependently, with SiNPs, but no significant decrease of cellular viability was observed up to concentrations of 100 μg/ml for three different sized SiNPs...
November 23, 2016: Scientific Reports
keyword
keyword
33111
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"