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https://www.readbyqxmd.com/read/29331589/the-iridocorneal-endothelial-syndrome
#1
REVIEW
Luis Silva, Ahmad Najafi, Yanin Suwan, Chaiwat Teekhasaenee, Robert Ritch
The iridocorneal endothelial syndrome (ICE) represents a unique group of ocular pathologies (Chandler syndrome, progressive iris atrophy, and Cogan-Reese syndrome) characterized by the proliferation of corneal endothelial cells that migrate toward the iridocorneal angle and iris surface causing, to a degree varying according to the subtype, corneal edema and decompensation, and secondary glaucoma, whether by obstructing the angle or producing peripheral anterior synechiae by contraction of the basement membrane of the migrating cells over the surface of the iris...
January 10, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29325546/development-and-evaluation-of-a-measure-of-patient-reported-symptoms-of-blepharitis
#2
Kamran Hosseini, Linda B Bourque, Ron D Hays
BACKGROUND: Blepharitis is an ocular surface disease and chronic ophthalmic condition. This paper reports on the development of psychometric evaluation of a patient-reported measure of blepharitis symptoms. METHODS: Self-reports of 13 blepharitis symptoms collected in a Phase 3 multi-site, randomized, double-masked, 4-arm parallel group, clinical trial of 907 individuals with blepharitis (mean age = 62, range: 19-93; 57% female) were analyzed. Symptoms asked about were: eyes that itch; eyes that burn; eyelids feel heavy or puffy; feel like something is in your eye; dry eyes; gritty eyes; irritated eyes; eyes that tear or water; crusty eyes; flaking from your eyelids; eyelids that are stuck together; red eyes or eyelids; and debris like pieces of skin or dandruff in your eyes...
January 11, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29325389/-development-of-en-face-optical-coherence-tomography-and-its-application-in-ocular-fundus-diseases
#3
Y Zhou, M Wang
Optical coherence tomography (OCT) is able to obtain the cross-sectional image of the fundus noninvasively and quickly. The cross-sectional image in vivo almost matches the histological section of the retina. OCT has become the most important imaging tool in ophthalmology. Based on the latest OCT technology, en face OCT is a new imaging technique that reveals the structure of retinal and choroidal sections approximately paralleled to the retina surface. Compared to the conventional OCT, en face OCT provides more comprehensive information and makes more accurate diagnosis and assessment of the prognosis...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29323424/in-vitro-and-in-vivo-effects-of-ophthalmic-solutions-on-silicone-hydrogel-bandage-lens-material-senofilcon-a
#4
Nejla B Erdal, Karin H Adolfsson, Sara De Lima, Minna Hakkarainen
BACKGROUND: Acuvue Oasys silicone hydrogel contact lenses (Senofilcon A) are used as bandage lenses and often combined with ophthalmic solutions in the treatment of ocular diseases. Concerns have been raised regarding the compatibility and effect of eye-drop solutions on the bandage lenses, which have led to frequent replacement of lenses causing clinical problems. Some patients experience pain or discomfort during treatments and the accumulation of drugs and preservatives in lenses has been suggested as a possible reason...
January 11, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29321303/infection-and-replication-of-influenza-virus-at-the-ocular-surface
#5
Hannah M Creager, Amrita Kumar, Hui Zeng, Taronna R Maines, Terrence M Tumpey, Jessica A Belser
Though influenza viruses typically cause respiratory tract disease, some viruses, particularly those with an H7 hemagglutinin, have been isolated from the eyes of conjunctivitis cases. Previous work has shown that isolates of multiple subtypes from both ocular and respiratory infections are capable of replication in human ex vivo ocular tissues and corneal or conjunctival cell monolayers, leaving the determinants of ocular tropism unclear. Here, we evaluated the effect of several variables on tropism for ocular cells cultured in vitro and examined the potential effect of the tear film on viral infectivity...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29320451/the-pathogenesis-of-staphylococcus-aureus-eye-infections
#6
REVIEW
Richard J O'Callaghan
Staphylococcus aureus is a major pathogen of the eye able to infect the tear duct, eyelid, conjunctiva, cornea, anterior and posterior chambers, and the vitreous chamber. Of these infections, those involving the cornea (keratitis) or the inner chambers of the eye (endophthalmitis) are the most threatening because of their potential to cause a loss in visual acuity or even blindness. Each of these ocular sites is protected by the constitutive expression of a variety of antimicrobial factors and these defenses are augmented by a protective host response to the organism...
January 10, 2018: Pathogens
https://www.readbyqxmd.com/read/29319444/use-of-2-octyl-cyanoacrylate-for-wound-closure-in-a-modified-roberts-bistner-procedure-for-eyelid-agenesis-in-five-cats-nine-eyes
#7
Zoe Reed, Clinton J Doering, Paul M Barrett
CASE DESCRIPTION 5 cats (9 eyes) were evaluated for surgical correction of bilateral eyelid agenesis. CLINICAL FINDINGS All eyes lacked > 25% of the temporal upper eyelid, and all cats had clinical signs attributable to chronic ocular exposure. Abnormalities were limited to the ocular surface in the 4 female cats, whereas the sole male cat had additional abnormalities consistent with anterior segment dysgenesis. TREATMENT AND OUTCOME A modified Roberts-Bistner procedure involving 2-octyl cyanoacrylate (2OCA) was performed on 9 eyes; 1 eye was enucleated...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29318383/optical-coherence-tomography-angiography-a-review-of-current-and-future-clinical-applications
#8
REVIEW
Marcus Ang, Anna C S Tan, Chui Ming Gemmy Cheung, Pearse A Keane, Rosa Dolz-Marco, Chelvin C A Sng, Leopold Schmetterer
Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age related macular degeneration and retinal vascular diseases...
January 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29318025/feline-dry-eye-syndrome-of-presumed-neurogenic-origin-a-case-report
#9
Lionel Sebbag, Patricia A Pesavento, Sebastian E Carrasco, Christopher M Reilly, David J Maggs
Case summary: A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29317327/sex-differences-in-clinical-characteristics-of-dry-eye-disease
#10
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs. METHODS: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex...
January 6, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29310465/annals-express-predictive-role-of-tear-protein-expression-in-the-early-diagnosis-of-sj%C3%A3-gren-s-syndrome
#11
Piera Versura, Giuseppe Giannaccare, Gentiana Vukatana, Rita Mulè, Nazzarena Malavolta, Emilio Campos
BACKGROUND: The contribution of tear protein expression in patients with presumed diagnosis of Sjogren Syndrome (SS) is underestimated. We aimed to evaluate the role of tear proteins in the SS early diagnosis. METHODS: Charts from 110 patients suspected of SS were analyzed and the subsequent diagnosis retrieved. Subjective symptoms (Ocular Surface Disease Index, OSDI), tear film break-up time (TFBUT), Schirmer test, Jones test, Tear Clearance (TC), corneal (NEI score) and conjunctival staining (van Bjerstelveldt score), esthesiometry, cytology, tear protein analysis [total protein (TP) content, Lysozyme-C (LYS-C), Lactoferrin (LACTO), Lipocalin-1 (LIPOC-1) and Albumin (ALB)] were analyzed...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29309844/development-of-an-in-vitro-model-to-study-the-biological-effects-of-blinking
#12
Guoting Qin, Hasna Baidouri, Adrian Glasser, VijayKrishna Raghunathan, Carol Morris, Inna Maltseva, Alison M McDermott
PURPOSE: To develop a mechanical model in which a contact lens is swept over ocular surface cells under conditions that mimic the force and speed of the blink, and to investigate the resulting biological changes. METHODS: A computer controlled mechanical instrument was developed to hold a dish containing 3D cultured stratified human ocular surface epithelial cells, across which an arm bearing a contact lens was swept back and forth repeatedly at a speed and force mimicking the human blink...
January 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29308960/collagen-cross-linking-in-the-management-of-microbial-keratitis
#13
Chiara Bonzano, Antonio Di Zazzo, Stefano Barabino, Giulia Coco, Carlo Enrico Traverso
Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treating keratitis due to multidrug resistant organisms. The purpose of this review is to discuss the rationale, safety, and evidence for CXL in infectious keratitis and its possible effect on ocular surface inflammation...
January 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29306088/changes-in-in-vivo-confocal-microscopic-findings-of-ocular-surface-squamous-neoplasia-during-treatment-with-topical-interferon-alfa-2b
#14
Mehran Zarei-Ghanavati, Ebrahim Mousavi, Amin Nabavi, Golshan Latifi, Hadi Z Mehrjardi, Masoomeh Mohebbi, Hamed Ghassemi, Farrin Mirzaie, Mohammad Ali Zare
PURPOSE: To evaluate in vivo confocal microscopy (IVCM) findings of ocular surface squamous neoplasia (OSSN) during treatment with topical interferon alfa-2b (IFN alfa-2b). METHODS: In this prospective interventional case series, 20 eyes from 20 patients with OSSN were treated with topical IFN alfa-2b 3 million IU/mL four times a day. Treatment was continued for 2 or 3 months after clinical resolution. IVCM was done at baseline, on a monthly basis, and at the end of treatment...
January 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29305607/novel-insight-into-the-role-of-cftr-in-lacrimal-gland-duct-function-in-mice
#15
Orsolya Berczeli, Eszter Vizvári, Máté Katona, Dénes Török, László Szalay, Ferenc Rárosi, István Németh, Zoltán Rakonczay, Péter Hegyi, Chuanqing Ding, Edit Tóth-Molnár
Purpose: The role of cystic fibrosis transmembrane conductance regulator (CFTR) in lacrimal gland (LG) function has only recently received some attention, mainly from our group. In the present study, we investigated the potential changes of LG pathology, tear secretion, ocular surface integrity, and fluid secretion in isolated LG ducts from CFTR knockout (KO) mice. Methods: Tear production and ocular surface integrity were investigated in anesthetized wild-type (WT) and KO mice using cotton threads and fluorescein staining, respectively...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29303147/optimising-tear-replacement-rheology-in-canine-keratoconjunctivitis-sicca
#16
D L Williams
Dry eye is a substantial problem in a large number of human and canine patients. Numerous laboratory models for tear deficiency exist using genetically predisposed rodent models, animals treated with topical anti-muscarinics, or those kept in environments with increased air flow to produce the ocular surface changes seen in human patients. Canine keratoconjunctivitis sicca, seen in many thousands of dogs kept as companion animals, can provide a valuable spontaneous model for testing tear replacement medications that might better model disease in human patients, existing as it does in an outbred population that live in the same environments as their owners...
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29300267/ocular-surface-workup-with-automated-noninvasive-measurements-for-the-diagnosis-of-meibomian-gland-dysfunction
#17
Giuseppe Giannaccare, Luca Vigo, Marco Pellegrini, Stefano Sebastiani, Francesco Carones
PURPOSE: To analyze diagnostic performance of an ocular surface workup based on automated noninvasive measurements in the diagnosis of meibomian gland dysfunction (MGD). METHODS: Two hundred ninety-eight eyes of 149 patients with MGD and 54 eyes of 27 control patients were analyzed. Ocular Surface Disease Index (OSDI), noninvasive breakup time (BUT), lipid layer thickness, meibomian gland loss, and tear osmolarity were calculated. The correlations among variables in the MGD group were analyzed...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29300260/dry-eye-assessment-in-patients-with-vitiligo
#18
Sevil Karaman Erdur, Rukiye Aydin, Ali Balevi, Mustafa Ozsutcu, Mehmet Selim Kocabora
PURPOSE: To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS: A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film breakup time, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29299768/optimization-biopharmaceutical-profile-and-therapeutic-efficacy-of-pioglitazone-loaded-plga-peg-nanospheres-as-a-novel-strategy-for-ocular-inflammatory-disorders
#19
Marcelle Silva-Abreu, Ana Cristina Calpena, Marta Espina, Amelia M Silva, Alvaro Gimeno, María Antonia Egea, María Luisa García
PURPOSE: The main goal of this study was to encapsulate Pioglitazone (PGZ), in biodegradable polymeric nanoparticles as a new strategy for the treatment of ocular inflammatory processes. METHODS: To improve their biopharmaceutical profile for the treatment of ocular inflammatory disorders, nanospheres (NSs) of PGZ were formulated by factorial design with poly (lactic-co-glycolic acid) polyethylene glycol (PLGA-PEG). Interactions drug-polymer have been carried out by spectroscopic (X-ray spectroscopy, FTIR) and thermal methods (DSC)...
January 3, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29297099/assessment-of-corneal-biomechanical-properties-with-inflation-test-using-optical-coherence-tomography
#20
Like Wang, Lei Tian, Yanping Huang, Yifei Huang, Yongping Zheng
Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method...
January 2, 2018: Annals of Biomedical Engineering
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