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https://www.readbyqxmd.com/read/28922696/does-air-gas-aesthesiometry-generate-a-true-mechanical-stimulus-for-corneal-sensitivity-measurement
#1
Daniela S Nosch, Heiko Pult, Julie Albon, Christine Purslow, Paul J Murphy
BACKGROUND: Belmonte Ocular Pain Meter (OPM) air jet aesthesiometry overcomes some of the limitations of the Cochet-Bonnet aesthesiometer. However, for true mechanical corneal sensitivity measurement, the airflow stimulus temperature of the aesthesiometer must equal ocular surface temperature (OST), to avoid additional response from temperature-sensitive nerves. The aim of this study was to determine: (A) the stimulus temperature inducing no or least change in OST; and (B) to evaluate if OST remains unchanged with different stimulus durations and airflow rates...
September 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28922328/minor-salivary-gland-transplantation-for-severe-dry-eyes
#2
Tais Hitomi Wakamatsu, Ana Estela Besteti Pires Ponce SantʼAnna, Priscila Cardoso Cristovam, Venâncio Avancini Ferreira Alves, Alda Wakamatsu, José Alvaro Pereira Gomes
Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness...
September 15, 2017: Cornea
https://www.readbyqxmd.com/read/28922088/semifluorinated-alkane-eye-drops-for-treatment-of-dry-eye-disease-due-to-meibomian-gland-disease
#3
Philipp Steven, Albert J Augustin, Gerd Geerling, Thomas Kaercher, Florian Kretz, Kathleen Kunert, Johannes Menzel-Severing, Norbert Schrage, Wolfgang Schrems, Sonja Krösser, Michael Beckert, Elisabeth M Messmer
PURPOSE: Meibomian gland disease is generally accepted as the leading cause for evaporative dry eye disease (DED). In a previous study, perfluorohexyloctane, a semifluorinated alkane, has been demonstrated to significantly increase tear film breakup time and to reduce corneal fluorescein staining in patients with evaporative DED, thereby vastly reducing dry eye-related symptoms. This study was set up to evaluate perfluorohexyloctane in a larger population of patients with Meibomian gland dysfunction...
September 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28922018/tacrolimus-ointment-for-refractory-posterior-blepharitis
#4
Fernando Eiji Sakassegawa-Naves, Helena Maria Moraes Ricci, Bernardo Kaplan Moscovici, Daniela Akemi Miyamoto, Brenda Biagio Chiacchio, Ricardo Holzchuh, Ruth Muyuki Santo, Richard Yudi Hida
PURPOSE: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. METHODS: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28920441/new-insight-of-common-regulatory-pathways-in-human-trabecular-meshwork-cells-in-response-to-dexamethasone-and-prednisolone-using-an-integrated-quantitative-proteomics-swath-and-mrm-hr-mass-spectrometry
#5
Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer, Chi Ho To
The molecular pathophysiology of corticosteroid-induced ocular hypertension (CIH) is not well understood. To determine the biological mechanisms of CIH, this study investigated protein expression profiles of human trabecular meshwork (hTM) cells in response to dexamethasone and prednisolone treatment. Both discovery-based Sequential Windowed data independent Acquisition of the Total High-resolution mass spectra (SWATH(TM)-MS) and targeted based high resolution multiple reaction monitoring (MRM-HR) confirmation were applied using a hybrid quadrupole-time-of-flight mass spectrometer...
September 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28919826/forehead-galeal-pericranial-flap-for-single-staged-total-upper-eyelid-reconstruction-in-sebaceous-gland-carcinoma-excision
#6
Hui-Hsiu Chang, Edward Suh, Blake H Fortes, Franklin Zheng, Anny Ms Cheng
PURPOSE: To present a successful case of single-staged total upper eyelid reconstruction after sebaceous gland carcinoma excision by using forehead galeal pericranial flap. OBSERVATIONS: An 80-year-old female with a progressively enlarged left upper eyelid mass presented with ocular irritation, blurred vision, and gritty sensation despite topical antibiotics treatment. This multinodular mass involved the left total upper eyelid, compromised corneal surface integrity, and caused complete ptosis...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28919660/collaborative-sdoct-segmentation-and-analysis-software
#7
Yeyi Yun, Aaron Carass, Andrew Lang, Jerry L Prince, Bhavna J Antony
Spectral domain optical coherence tomography (SDOCT) is routinely used in the management and diagnosis of a variety of ocular diseases. This imaging modality also finds widespread use in research, where quantitative measurements obtained from the images are used to track disease progression. In recent years, the number of available scanners and imaging protocols grown and there is a distinct absence of a unified tool that is capable of visualizing, segmenting, and analyzing the data. This is especially noteworthy in longitudinal studies, where data from older scanners and/or protocols may need to be analyzed...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28919183/impact-of-oral-vitamin-d-supplementation-on-the-ocular-surface-in-people-with-dry-eye-and-or-low-serum-vitamin-d
#8
Chih-Huang Yang, Julie Albietz, Damien G Harkin, Michael G Kimlin, Katrina L Schmid
PURPOSE: To determine the possible association between serum vitamin D levels and dry eye symptoms, and the impact of an oral vitamin D supplement. METHODS: Three linked studies were performed. (i) 29 older adult participants, (ii) 29 dry eyed participants, and (iii) 2-month vitamin D supplementation for 32 dry eyed/low serum vitamin D levelled participants. All participants were assessed by the Ocular Surface Diseases Index (OSDI) to determine dry eye symptoms, and the phenol red thread test (PRT) and/or Schirmer's tear test, tear meniscus height, non-invasive tear break up time, grading ocular surface redness and fluorescein staining of the cornea to detect the tear quality and ocular surface conditions...
September 11, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28918083/topical-fluorometholone-treatment-and-desiccating-stress-change-inflammatory-protein-expression-in-tears
#9
Janika Nättinen, Antti Jylhä, Ulla Aapola, Amalia Enríquez-de-Salamanca, José Pinto-Fraga, Alberto López-Miguel, María J González-García, Michael E Stern, Margarita Calonge, Lei Zhou, Matti Nykter, Hannu Uusitalo, Roger Beuerman
PURPOSE: It was hypothesized that tear protein biomarkers could predict the effects of topical steroid treatment and desiccating stress in patients with dry eye disease (DED). To test this concept, a randomized, double-masked, controlled clinical trial with 41 patients was conducted. METHODS: The patients were treated topically with either 0.1% fluorometholone (FML) or polyvinyl alcohol (PA). Tear samples were collected using 1 μl glass capillaries at recruitment into the study and after a 3-week treatment period, both before and after 2 h exposure to desiccating stress, in a controlled environment chamber...
September 13, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28918058/reducible-peg-pod-dna-nanoparticles-for-gene-transfer-in%C3%A2-vitro-and-in%C3%A2-vivo-application-in-a-mouse-model-of-age-related-macular-degeneration
#10
Bhanu Chandar Dasari, Siobhan M Cashman, Rajendra Kumar-Singh
Non-viral gene delivery systems are being developed to address limitations of viral gene delivery. Many of these non-viral systems are modeled on the properties of viruses including cell surface binding, endocytosis, endosomal escape, and nuclear targeting. Most non-viral gene transfer systems exhibit little correlation between in vitro and in vivo efficiency, hampering a systematic approach to their development. Previously, we have described a 3.5 kDa peptide (peptide for ocular delivery [POD]) that targets cell surface sialic acid...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28914974/mucocutaneous-inflammation-in-the-ikaros-family-zinc-finger-1-ikzf1-keratin-5-specifc-transgenic-mice
#11
Mayumi Ueta, Junji Hamuro, Hiromi Nishigaki, Naomi Nakamura, Katsuhiko Shinomiya, Katsura Mizushima, Yuki Hitomi, Risa Tamagawa-Mineoka, Norihiko Yokoi, Yuji Naito, Katsushi Tokunaga, Norito Katoh, Chie Sotozono, Shigeru Kinoshita
BACKGROUND: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. METHODS: Human skin and conjunctival tissues were obtained for immunohistological studies. Primary human conjunctival epithelial cells (PHCjECs) and adult human epidermal keratinocytes (HEKa) also used for gene expression analysis...
September 15, 2017: Allergy
https://www.readbyqxmd.com/read/28912992/giant-conjunctival-nevus-in-a-12-year-old-child
#12
Edit Tóth-Molnár, Eszter Vizvári, Ákos Skribek, András Vörös
We describe a case of a giant conjunctival nevus presented in a 12-year-old girl with suspicious clinicomorphological appearance. The lesion was noticed by the parents at the age of 3 years as a "fleshy spot" on the bulbar conjunctiva. The lesion remained unchanged until approx. 6 months before recent admission. On slit-lamp examination, a large conjunctival lesion with variegate pigmentation and indistinct margins was detected on the superonasal part of the bulbar conjunctiva of the left eye. Intralesional cysts and vessels were detected with AS-OCT examination...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28910571/factors-that-influence-tear-meniscus-area-and-conjunctivochalasis-the-singapore-indian-eye-study
#13
Stanley Poh, Ryan Lee, Jennifer Gao, Carin Tan, Preeti Gupta, Charumathi Sabanayagam, Ching-Yu Cheng, Tien-Yin Wong, Louis Tong
PURPOSE: Assessment of tear film and conjunctiva is critical to define presence and severity of ocular surface disease. We aimed to characterize tear meniscus area (TMA) and conjunctivochalasis by anterior segment optical coherence tomography (ASOCT) in population-based patients and identify potential factors associated with low TMA and severe conjunctivochalasis. METHODS: Study subjects were enrolled from The Singapore Indian Eye Study, a population-based study of Asian Indian in Singapore...
September 14, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28910552/the-use-of-topical-corticosteroids-for-treatment-of-dry-eye-syndrome
#14
Carlo Alberto Cutolo, Stefano Barabino, Chiara Bonzano, Carlo Enrico Traverso
Dry eye disease (DED) is a multifactorial disease that results in symptoms of discomfort, visual disturbance, and damage to the ocular surface. Because chronic inflammation plays an important role in DED, treatment with topical corticosteroids has been demonstrated to ameliorate the signs and symptoms of the disease. Although these agents have proven short-term efficacy, their long-term use may cause intraocular pressure elevation and cataract progression. A carefully review of the different studies shows that differences between corticosteroids may exist regarding the incidence of side effects and evidence of efficacy in DED patients...
September 14, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28910455/development-and-evaluation-of-semiautomated-quantification-of-lissamine-green-staining-of-the-bulbar-conjunctiva-from-digital-images
#15
Vatinee Y Bunya, Min Chen, Yuanjie Zheng, Mina Massaro-Giordano, James Gee, Ebenezer Daniel, Ryan O'Sullivan, Eli Smith, Richard A Stone, Maureen G Maguire
Importance: Lissamine green (LG) staining of the conjunctiva is a key biomarker in evaluating ocular surface disease. The disease currently is assessed using relatively coarse subjective scales. Objective assessment would standardize comparisons over time and between clinicians. Objective: To develop a semiautomated, quantitative system to assess lissamine green staining of the bulbar conjunctiva on digital images. Design, Setting, and Participants: Using a standard photography protocol, 35 digital images of the conjunctiva of 11 patients with a diagnosis of dry eye disease based on characteristic signs and symptoms were obtained after topical administration of preservative-free LG, 1%, solution...
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28910157/photochemical-cross-linking-for-penetrating-corneal-wound-closure-in-enucleated-porcine-eyes
#16
Ti Wang, Lu Zhu, Yinbo Peng, Nianci Shen, Yan Yu, Min Yao, Jingyin Zhu
PURPOSE: To compare the efficacy of photochemical-induced tissue cross-linking (PCL), utilizing Rose Bengal (RB) and 532 nm green light irradiation (RB-PCL), with standard sutures for closure of penetrating corneal incision in porcine cadaver eyes. METHODS: A full-thickness penetrating incision, 3 mm in length parallel to the limbus and perpendicular to the corneal surface, was made in the enucleated porcine cornea. Photochemical cross-linking was performed with tropical RB application and irradiation of 532 nm green light (0...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28902875/interferon-%C3%AE-treatment-in-vitro-elicits-some-of-the-changes-in-cathepsin-s-and-antigen-presentation-characteristic-of-lacrimal-glands-and-corneas-from-the-nod-mouse-model-of-sj%C3%A3-gren-s-syndrome
#17
Zhen Meng, Wannita Klinngam, Maria C Edman, Sarah F Hamm-Alvarez
Inflammation and impaired secretion by lacrimal and salivary glands are hallmarks of the autoimmune disease, Sjögren's Syndrome. These changes in the lacrimal gland promote dryness and inflammation of the ocular surface, causing pain, irritation and corneal damage. The changes that initiate and sustain autoimmune inflammation in the lacrimal gland are not well-established. Here we demonstrate that interferon-γ (IFN-γ) is significantly elevated in lacrimal gland and tears of the male NOD mouse, a model of autoimmune dacryoadenitis which exhibits many ocular characteristics of Sjögren's Syndrome, by 12 weeks of age early in lacrimal gland inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28902722/diagnostic-approach-to-ocular-infections-using-various-techniques-from-conventional-culture-to-next-generation-sequencing-analysis
#18
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Imaohji, Chika Miyazaki, Miou Hirose, Shunji Kusaka, Masahiko Fukuda, Yoshikazu Shimomura
Ocular infection is caused by both endogenous (resident) and exogenous (environmental) microbes. As the ocular surface interacts with both outer environment and its own resident microbiota, clinical ocular samples are predicted to contain a diverse set of microorganisms. Microscopy of sample smears is an important step in the diagnostic process of infectious diseases to interpret the culture results. Traditional culture techniques have several limitations in the detection and/or identification of uncharacterized bacteria of environmental origin...
September 11, 2017: Cornea
https://www.readbyqxmd.com/read/28902719/wound-closure-and-tissue-adhesives-in-clear-corneal-incision-cataract-surgery
#19
Amy Y Tong, Preeya K Gupta, Terry Kim
PURPOSE OF REVIEW: Achieving secure wound closure in clear corneal incision cataract surgery remains highly desired for its role in reducing infection risk and leak-related complications, including hypotony, corneal edema, and lens dislocation. Although classic techniques of stromal hydration or wound suturing represent traditional approaches, the introduction of newer and more effective ocular surface adhesives has increased the options that are available. This review aims to provide an update on the peer-reviewed literature regarding wound closure and the currently available and investigational tissue adhesives used to seal clear corneal incisions in cataract surgery...
September 11, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28902017/ocular-demodicosis-as-a-potential-cause-of-ocular-surface-inflammation
#20
Xiaohui Luo, Jing Li, Chuan Chen, Scheffer Tseng, Lingyi Liang
Among different species of mites, Demodex folliculorum and Demodex brevis are the only 2 that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. In this study, we summarize our research experience including our most recent study regarding Demodex infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn...
September 7, 2017: Cornea
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