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https://www.readbyqxmd.com/read/28448672/correlation-between-the-inflammatory-marker-hla-dr-and-signs-and-symptoms-in-moderate-to-severe-dry-eye-disease
#1
Françoise Brignole-Baudouin, Luisa Riancho, Dahlia Ismail, Maëva Deniaud, Mourad Amrane, Christophe Baudouin
Purpose: To investigate correlations of the inflammatory HLA-DR marker with clinical signs and symptoms commonly used to assess dry eye disease (DED) severity. Methods: Baseline data were collected from three clinical studies conducted on moderate to severe DED patients. Characteristics of DED were analyzed and correlations were performed in 311 patients. Data were analyzed after treatment with 1 mg/mL cyclosporine (CsA) and vehicle. We quantified HLA-DR by flow cytometry in impression cytology specimens...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28446156/conjunctival-granuloma-with-necrosis-associated-with-exposed-suture-in-upper-double-lid-masquerading-as-ocular-surface-squamous-neoplasia-a-case-report
#2
Yu Jeong Kim, Jaeyoung Kim, Hokyung Choung, Mee Kum Kim, Won Ryang Wee
BACKGROUND: This study reports two cases of conjunctival granuloma with necrosis caused by an exposed suture in the upper palpebral conjunctiva masquerading as ocular surface squamous neoplasia. CASE PRESENTATION: Two patients presented with chronic conjunctival ulcerative and granulomatous lesions on the superior bulbar conjunctiva that repeatedly recurred after the mass was removed. The pathologic findings revealed the absence of malignant cells and presence of many lymphocytes, plasma cells, and histiocytes...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28445524/live-imaging-of-primary-ocular-vasculature-formation-in-zebrafish
#3
Tetsuya Hashiura, Eiji Kimura, Shizuko Fujisawa, Sayuri Oikawa, Shigenori Nonaka, Daijiro Kurosaka, Jiro Hitomi
Ocular vasculature consists of the central retinal and ciliary vascular systems, which are essential to maintaining visual function. Many researchers have attempted to determine their origins and development; however, the detailed, stepwise process of ocular vasculature formation has not been established. In zebrafish, two angioblast clusters, the rostral and midbrain organizing centers, form almost all of the cranial vasculature, including the ocular vasculature, and these are from where the cerebral arterial and venous angioblast clusters, respectively, differentiate...
2017: PloS One
https://www.readbyqxmd.com/read/28445193/a-pilot-randomized-trial-on-safety-and-efficacy-of-a-novel-topical-combined-inhibitor-of-janus-kinase-1-3-and-spleen-tyrosine-kinase-for-gvhd-associated-ocular-surface-disease
#4
Ahmad Kheirkhah, Antonio Di Zazzo, Vannarut Satitpitakul, Merle Fernandez, Daniel Magilavy, Reza Dana
PURPOSE: Janus kinase (JAK) and spleen tyrosine kinase (SYK) play critical functions in T-cell activation and in inflammation. Because of their antiinflammatory effects, JAK and SYK inhibitors have recently been evaluated in several immunopathogenic disorders. This pilot study was designed to assess the safety and efficacy of a topical combined JAK/SYK inhibitor, R348, ophthalmic solution for treatment of ocular surface disease in graft-versus-host disease (GVHD). METHODS: This phase 2, double-masked, randomized, pilot trial included 30 patients with ocular surface disease due to GVHD who were randomized to receive topical 0...
April 25, 2017: Cornea
https://www.readbyqxmd.com/read/28442688/ocular-surface-and-external-filtration-surgery-mutual-relationships
#5
Christophe Baudouin
There is a large body of evidence from clinical and experimental studies indicating that the long-term use of topical drugs may induce ocular surface changes, causing ocular discomfort, dry eye, conjunctival inflammation, subconjunctival fibrosis, corneal surface impairment, and, as a consequence of chronic ocular surface changes, the potential risk of failure for further glaucoma surgery. Subclinical inflammation has also been widely described in patients receiving antiglaucoma treatments for long periods of time, with inflammatory cell infiltration and fibroblast activation in the conjunctiva and subconjunctival space...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442683/achievements-and-limits-of-current-medical-therapy-of-glaucoma
#6
Pelagia Kalouda, Christina Keskini, Eleftherios Anastasopoulos, Fotis Topouzis
Prescribing medical therapy for the treatment of glaucoma can be a complex process since many parameters should be taken into consideration regarding its achievements and limits. Today, a variety of options, including multiple drug classes and multiple agents within classes, are available to the clinician, but caution should be given to their side effects and contraindications. Glaucoma patients with preexisting ocular surface disease should be treated with caution, and preferably with preservative-free formulations, as there is an increased risk for symptom deterioration...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442381/ocular-surface-alkali-injury-damages-meibomian-glands-in-mice
#7
Shin Mizoguchi, Hiroki Iwanishi, Masahide Kokado, Takayoshi Sumioka, Geraint J Parfitt, Yilu Xie, Reiko Arita, Rika Shirakawa, Osamu Yamanaka, Yuka Okada, James V Jester, Shizuya Saika
PURPOSE: To examine effects of alkali injury of the ocular surface on meibomian gland pathology in mice. METHODS: Three μL of 1 N NaOH were applied under general anesthesia to the right eye of 10-week-old BALB/c (n = 54) mice to produce a total ocular surface alkali burn. The meibomian gland morphology was examined at days 1, 2, 5, 10, and 20 by stereomicroscopy and non-contact infrared meibography. Mice were then sacrificed and eyelids processed for histology with hematoxylin-eosin and immunohistochemistry for ELOVL4, PPARγ, myeloperoxidase (a neutrophil marker) and F4/80 macrophage antigen, as well as TUNEL staining...
April 22, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28441413/langerhans-cells-prevent-subbasal-nerve-damage-and-upregulate-neurotrophic-factors-in-dry-eye-disease
#8
Eun Young Choi, Hyun Goo Kang, Chul Hee Lee, Areum Yeo, Hye Mi Noh, Nayeong Gu, Myoung Joon Kim, Jong Suk Song, Hyeon Chang Kim, Hyung Keun Lee
The functional role of Langerhans cells (LCs) in ocular surface inflammation and nerve damage in dry eye (DE) disease has yet to be determined. This study was performed to investigate this relationship through both clinical study on DE patients and in vivo mouse models with induced DE disease. In a cross-sectional case-control study (54 eyes of DE patients; 34 eyes of control patients), average cell density, area, and process length of LCs were measured using confocal microscopy. Data were analyzed to determine whether changes in LCs are correlated with subbasal nerve plexus (SNP) parameters (nerve density, beading, and tortuosity)...
2017: PloS One
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#9
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
April 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28441068/a-controlled-randomized-double-blind-study-to-evaluate-the-safety-and-efficacy-of-chitosan-n-acetylcysteine-for-the-treatment-of-dry-eye-syndrome
#10
Doreen Schmidl, René Werkmeister, Semira Kaya, Angelika Unterhuber, Katarzyna J Witkowska, Renate Baumgartner, Sonja Höller, Maria O'Rourke, Ward Peterson, Annika Wolter, Martin Prinz, Leopold Schmetterer, Gerhard Garhöfer
PURPOSE: This study was designed to evaluate the effect of chitosan-N-acetylcysteine (C-NAC) eye drops on tear film thickness (TFT) in patients with dry eye syndrome (DES). METHODS: This was a controlled, randomized, double-blind clinical investigation with patients assigned to 2 cohorts. In Cohort I, 21 patients were randomized to receive 1 instillation of C-NAC eye drops in 1 eye and placebo (normal saline solution) in the contralateral eye. In Cohort II, 17 patients were randomized to receive C-NAC eye drops once (QD) or twice (BID) daily for 5 days...
April 25, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28440253/evaluation-of-meibomian-gland-and-tear-film-changes-in-patients-with-pterygium
#11
Fen Ye, Fen Zhou, Yuan Xia, Xiaomin Zhu, Yan Wu, Zhenping Huang
BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes from forty patients with primary nasal pterygium and forty eyes from forty volunteers without ocular pathologies were enrolled in this study. Ocular surface disease index scores, meibomian gland expression scores, lid margin abnormality scores, meiboscore, tear film breakup time (BUT), Schirmer test (SIT) value, and the lower tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) using Fourier domain optical coherence were performed...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28440250/outcomes-of-deep-anterior-lamellar-keratoplasty-following-autologous-simple-limbal-epithelial-transplant-in-pediatric-unilateral-severe-chemical-injury
#12
Divya Singh, M Vanathi, Chanchal Gupta, Noopur Gupta, Radhika Tandon
AIMS: To evaluate outcomes of deep anterior lamellar keratoplasty (DALK) in pediatric eyes with unilateral severe chemical injury which have undergone autologous simple limbal epithelial transplant (SLET). SETTINGS AND DESIGN: The study design was a retrospective case series. MATERIALS AND METHODS: This retrospective, case series of all children <16 years of age that have undergone DALK following autologous SLET procedure in unilateral severe chemical injury evaluates the outcomes and complications in the setting of a tertiary care center in North India...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28439655/-ocular-graft-versus-host-disease-corneal-complications
#13
H Westekemper, S L Scholz, H Thomasen, C Halfwassen, K-P Steuhl
BACKGROUND: Ocular graft-versus-host disease (GvHD) following allogeneic blood stem cell transplantation leads to immunologically induced alterations in many ocular tissues, particularly at the ocular surface. Within the framework of the main topic, this article focuses primarily on corneal complications in chronic ocular GvHD. OBJECTIVE: This article aims to promote understanding of the influencing factors, diagnostics, and therapeutic options pertaining to corneal complications in ocular GvHD...
April 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28437175/pharmacokinetics-and-safety-of-travoprost-0-004-ophthalmic-solution-preserved-with-polyquad-in-pediatric-patients-with-glaucoma
#14
Erin Stahl, Dominique Bremond-Gignac, Theresa Landry, Mike Curtis, Kinfemichael Gedif, Sami Al Shahwan, El Roy Dixon
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of travoprost 0.004% preserved with Polyquad(®) (TRAVATAN(®)) in pediatric patients with glaucoma or ocular hypertension. METHODS: This was a phase 1, open-label, multicenter clinical study of patients aged ≥2 months to <18 years. Patients received daily administration of travoprost 0.004% preserved with Polyquad in both eyes for 7 days. Plasma samples were collected 30 min before the final dose and at 10, 20, 40, and 80 min postdose...
February 24, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28435216/pain-perception-description-after-advanced-surface-ablation
#15
Eva M Sobas, Sebastián Videla, Amanda Vázquez, Itziar Fernández, Miguel J Maldonado, José-Carlos Pastor
PURPOSE: The objective of this study was to characterize the evolution of ocular pain after advanced surface ablation (ASA) to improve strategies in postoperative pain management. METHODS: This was a multicenter, prospective, descriptive, cohort study. The inclusion criteria were healthy individuals ≥18 years old receiving bilateral alcohol-assisted surface ablation with epithelial removal. Pain intensity was evaluated with the visual analog scale (VAS) and the numeric pain rating scale before and after surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28435213/comparison-of-0-2-and-0-18-hyaluronate-eye-drops-in-patients-with-moderate-to-severe-dry-eye-with-keratitis-or-keratoconjunctivitis
#16
Dorothea Groß, Marc Childs, Jean-Marie Piaton
PURPOSE: Comparison of efficacy and safety of 0.2% and 0.18% hyaluronic acid (HA) eye drops three times a day (tid) in patients with moderate to severe dry eye disease, related to keratitis or keratoconjunctivitis. PATIENTS AND METHODS: Prospective, multicenter, randomized, single-masked, phase IIIb, noninferiority study (0.2% HA vs 0.18% HA) in two parallel groups over a period of 84 days. N=70 patients were evaluated. Primary efficacy outcome was ocular surface (OS) staining change on day 35 (D35), compared to baseline...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28433820/effects-of-punctal-occlusion-on-global-tear-proteins-in-patients-with-dry-eye
#17
Louis Tong, Lei Zhou, Roger Beuerman, Susan Simonyi, David A Hollander, Michael E Stern
PURPOSE: To investigate effects of punctal occlusion on global tear protein levels in patients with dry eye. METHODS: In this prospective, longitudinal, single-center study, nonabsorbable punctal plugs were inserted bilaterally into the lower punctum of 30 patients with moderate dry eye. Dry eye symptoms, fluorescein corneal staining, Schirmer I test, tear film break-up time, and safety were assessed in the more severe eye. Tear proteins at weeks 1 and 3 were quantified by iTRAQ relative to baseline preocclusion levels...
April 19, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28430702/re-tear-function-and-ocular-surface-alterations-after-accelerated-corneal-collagen-crosslinking-in-progressive-keratoconus
#18
Emine Kalkan Akcay, Betul Seher Uysal
No abstract text is available yet for this article.
May 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28430701/tear-function-and-ocular-surface-alterations-after-accelerated-corneal-collagen-crosslinking-in-progressive-keratoconus
#19
Zisis Gatzioufas, Mohamed Elalfy, Samer Hamada, Damian Lake
No abstract text is available yet for this article.
May 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28430334/chondro-keratoprosthesis-an-alternative-to-ookp
#20
Louis Hoffart, Laurent Guyot
PURPOSE: To evaluate the use of cartilage as a potential graft material toward osteo-odontal tissue replacement in keratoprosthesis surgery. METHODS: We describe a modification of the osteo-odonto-keratoprosthesis surgery that involves the use of autologous auricular conchal cartilage graft (ACCG). In stage 1a, a full-thickness cheek mucosa graft was performed over the ocular surface. In stage 1b, ACCG was harvested via a retroauricular approach. An optical polymethyl-methacrylate cylinder was embedded into a double-layered fragment of cartilage and secured by cyanoacrylate glue...
April 4, 2017: European Journal of Ophthalmology
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