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https://www.readbyqxmd.com/read/28636406/protective-effect-of-intravitreal-administration-of-exosomes-derived-from-mesenchymal-stem-cells-on-retinal-ischemia
#1
Elad Moisseiev, Johnathon D Anderson, Sharon Oltjen, Mayank Goswami, Robert J Zawadzki, Jan A Nolta, Susanna S Park
PURPOSE: Exosomes derived from human mesenchymal stem cells (hMSCs) cultured under hypoxic conditions contain proteins and growth factors that promote angiogenesis. This study investigated the effect of intravitreal administration of these exosomes on retinal ischemia using a murine model. METHODS: Oxygen-induced retinopathy (OIR) was induced by exposing one-week-old male C57BL/6J mice to 5 days of 75% hyperoxic conditioning, and returning to room air. After hyperoxic conditioning, the right eye of each mouse was injected intravitreally with 1 µl saline or exosomes derived from hMSCs and compared to control mice of the same age raised in room air without OIR injected intravitreally with saline...
June 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28634142/cysteamine-polysaccharide-hydrogels-study-of-extended-ocular-delivery-and-biopermanence-time-by-pet-imaging
#2
Andrea Luaces-Rodríguez, Victoria Díaz-Tomé, Miguel González-Barcia, Jesús Silva-Rodríguez, Michel Herranz, María Gil-Martínez, María Teresa Rodríguez-Ares, Carla García-Mazás, José Blanco-Mendez, María Jesús Lamas, Francisco Javier Otero-Espinar, Anxo Fernández-Ferreiro
Cystinosis is a rare autosomal recessive disorder in which cystine crystals accumulate within the lysosomes of various organs, including the cornea. Ocular treatment is based on the administration of cysteamine eye drops, requiring its instillation several times per day. We have introduced the cysteamine in two types of previously developed ocular hydrogels (ion sensitive hydrogel with the polymers gellan gum and kappa-carrageenan and another one composed of hyaluronic acid), aiming at increasing the ocular retention in order to extend the dosing interval...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28634139/ocular-disposition-of-ciprofloxacin-from-topical-pegylated-nanostructured-lipid-carriers-effect-of-molecular-weight-and-density-of-poly-ethylene-glycol
#3
Sai Prachetan Balguri, Goutham R Adelli, Karthik Yadav Janga, Prakash Bhagav, Soumyajit Majumdar
Ciprofloxacin (CIP) is an antibacterial agent prescribed for the treatment of ocular infections. The objective of the present project is to investigate the effect of surface PEG functionalization of the Nano structured lipid carriers (NLCs) on formulation stability, ocular penetration and distribution. CIP NLCs were tested with different molecular weight (poly ethylene glycol) PEGs ranging from (2K to 20K) grafted onto the phospholipid and with different chain lengths (14-18 carbons) of phospholipids derivatized with PEG-2K...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28629084/facilitation-of-transscleral-drug-delivery-by-drug-loaded-magnetic-polymeric-particles
#4
Zeynab Mousavikhamene, Mohammad J Abdekhodaie, Hamid Ahmadieh
A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628490/comparison-of-efficacy-of-difluprednate-0-05-and-loteprednol-gel-0-5-after-cataract-surgery
#5
Bryan Abessi, Lauren Brooksby, Robert L Schultze
PURPOSE: To compare the outcomes and complications of topical difluprednate 0.05% and loteprednol gel 0.5% after routine cataract surgery. METHODS: Subjects received either difluprednate emulsion 0.05% (n=30 eyes) or loteprednol gel 0.5% (n=30 eyes) after routine cataract surgery. Topical steroid drops were initiated 3 days before cataract surgery and continued for 2 weeks postoperatively. Anterior chamber (AC) cell grade, corneal edema, corneal pachymetry, visual acuity, ocular surface quality (Oxford scale), and intraocular pressure (IOP) were evaluated at 1 day, 1 week, and 1 month postoperatively...
June 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#6
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28626853/conjunctival-melanoma-in-southwestern-nigeria-a-case-series-and-review-of-literature
#7
Oluyemi Fasina, Olayiwola A Oluwasola
PURPOSE: Conjunctival melanoma is a rare tumor worldwide and is extremely rare among black population. This study aims to report the demographics, clinical presentation, treatment, and outcome of patients seen in an indigenous black population in Southwestern Nigeria. METHODS: All patients histologically diagnosed with conjunctival melanoma and managed in the facility were reviewed. Their demographics, clinical presentation, treatment received, outcome of treatment, and histopathological features were analyzed...
June 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#8
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28622318/characteristics-of-symptoms-experienced-by-persons-with-dry-eye-disease-while-driving-in-china
#9
Y Wang, H Lv, Y Liu, X Jiang, M Zhang, X Li, W Wang
PurposeTo assess the vision-related quality of life and self-reported driving performance of patients with dry eye disease (DED).Patients and methodsThe study was performed in the eye centre of Peking University Third Hospital, China. In total, 87 dry eye patients and 42 controls were enroled, including 49 patients without any treatment (group A), 38 patients treated with artificial tears (group B) and 42 controls without DED (group C). The participants had no eye disease other than DED. Scores of a vision-related quality-of-life questionnaire (Ocular Surface Disease Index (OSDI)), a daily life-related visual function questionnaire and a questionnaire about performance during driving were collected...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28620965/determination-of-retinal-surface-area
#10
Manbir Nagra, Bernard Gilmartin, Ngoc Jade Thai, Nicola S Logan
Previous attempts at determining retinal surface area and surface area of the whole eye have been based upon mathematical calculations derived from retinal photographs, schematic eyes and retinal biopsies of donor eyes. 3-dimensional (3-D) ocular magnetic resonance imaging (MRI) allows a more direct measurement, it can be used to image the eye in vivo, and there is no risk of tissue shrinkage. The primary purpose of this study is to compare, using T2-weighted 3D MRI, retinal surface areas for superior-temporal (ST), inferior-temporal (IT), superior-nasal (SN) and inferior-nasal (IN) retinal quadrants...
June 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28620707/treatment-of-patients-with-neurotrophic-keratitis-stages-2-and-3-with-plasma-rich-in-growth-factors-prgf-endoret-eye-drops
#11
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Ana Cristina Riestra, Luis Fernandez-Vega Cueto, Eduardo Anitua, Leire Begoña, Francisco Muruzabal, Gorka Orive
PURPOSE: To provide preliminary data about efficacy and safety of plasma rich in growth factors (PRGF) eye-drops in neurotrophic keratitis (NK) and to analyze the possible influence of certain variables on treatment outcomes. METHODS: This retrospective study included patients with stages 2-3 of NK treated with PRGF eye-drops. Primary endpoint was the resolution time of corneal ulcer defect. Outcome measures including percentage of ulcer closure at 4 weeks, Ocular Surface Disease Index (OSDI), Best-Corrected Visual Acuity (BCVA) and Visual Analogue Scale (VAS) were also evaluated before and after treatment with PRGF...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28618301/noninvasive-measurement-of-wave-speed-of-porcine-cornea-in-ex-vivo-porcine-eyes-for-various-intraocular-pressures
#12
Boran Zhou, Arthur J Sit, Xiaoming Zhang
The objective of this study was to extend an ultrasound surface wave elastography (USWE) technique for noninvasive measurement of ocular tissue elastic properties. In particular, we aim to establish the relationship between the wave speed of cornea and the intraocular pressure (IOP). Normal ranges of IOP are between 12 and 22mmHg. Ex vivo porcine eye balls were used in this research. The porcine eye ball was supported by the gelatin phantom in a testing container. Some water was pour into the container for the ultrasound measurement...
June 7, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28617732/the-effects-of-latanoprost-with-benzalkonium-chloride-versus-travoprost-with-sofzia-on-the-ocular-surface
#13
Kamran Rahmatnejad, Christopher J Rapuano, Parul Ichhpujani, Sheryl S Wizov, Marlene R Moster, Lisa A Hark, L Jay Katz
PURPOSE: To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z). METHODS: In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617729/demographic-characteristics-and-prescribing-patterns-of-scleral-lens-fitters-the-scope-study
#14
Cherie B Nau, Jennifer Harthan, Ellen Shorter, Joseph Barr, Amy Nau, Nicolette T Chimato, David O Hodge, Muriel M Schornack
OBJECTIVES: This study reports demographic characteristics of scleral lens providers and indications for scleral lens prescription as assessed by a worldwide online survey. METHODS: The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group designed the online survey regarding current scleral lens prescription and management practices. The Mayo Clinic Survey Research Center administered the survey, which was open from January 15 to March 31, 2015...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28613354/the-quantitative-measurements-of-vascular-density-and-flow-areas-of-macula-using-optical-coherence-tomography-angiography-in-normal-volunteers
#15
Fariba Ghassemi, Kaveh Fadakar, Fatemeh Bazvand, Reza Mirshahi, Masoumeh Mohebbi, Siamak Sabour
BACKGROUND AND OBJECTIVE: The quantification of the density of macular vascular networks and blood flow areas in the foveal and parafoveal area in healthy subjects using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional, prospective study in an institutional setting at the Retina Services of Farabi Eye Hospital. One hundred twelve normal volunteers with no known ocular or systemic disease were included, including patient numbers (one or both eyes), selection procedures, inclusion/exclusion criteria, randomization procedure, and masking...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28612893/the-mixture-of-bifidobacterium-associated-with-fructo-oligosaccharides-reduces-the-damage-of-the-ocular-surface
#16
G Chisari, E M Chisari, A Francaviglia, C G Chisari
BACKGROUND: Despite its high prevalence Dry Eye Syndrome (DES) in frequently under-recognized owing to its negative influence on patients visual function. METHODS: This clinical trial was a pilot study to evaluate the effects of supplementation with mixture (Bifidobacterium lactis and Bifidobacterium bifido) on the tear film. Following the run-in period subjects were randomized in two groups: group A (N°20 subjects) and group B (N°20 subjects). Group A (control) treated only with substitute tear and group B treated with substitute tear + mixture (symbiotic)...
May 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28606267/-comparison-of-two-kinds-of-artificial-tears-on-the-dry-eye-after-phacoemulsification
#17
R You, J Wang, Y Han, L J Liu, W Y Wang
Objective: To compare the curative effect of two different artificial tears on dry eye after phacoemulsification. Methods: Prospective randomized controlled clinical trial. From March to June in 2012, 102 patients (102 eyes) with age-related cataract were treated with phacoemulsification at Beijing Tongren Hospital, Capital University of Medical Sciences, and these eyes were randomly divided into blank group (group A ) 32 cases, treatment group 1 (group B) 35 cases and treatment group 2 (group C) 35 cases. Group A was treated with conventional antibiotics...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28604356/ocular-surface-temperature-in-patients-with-evaporative-and-aqueous-deficient-dry-eyes-a-thermographic-approach
#18
Sara Matteoli, Eleonora Favuzza, Lucrezia Mazzantini, Pasquale Aragona, Stefania Cappelli, Andrea Corvi, Rita Mencucci
In recent decades infrared thermography (IR) has allowed accurate and quantitative measurements of the ocular surface temperature (OST), applying a non-invasive procedure. The objective of this work was to develop a procedure based on IR, which allows characterizing the cooling of the ocular surface of patients suffering from dry eye syndrome, and distinguishing among patients suffering from aqueous deficient dry eye (ADDE) and evaporative dry eyes (EDE). Approach: All patients examined (34F/4M, 23-84 years) were divided into two groups according to their Schirmer I result (≤7 mm for ADDE and >7 mm for EDE), and the OST was recorded for 7 s at 30Hz...
June 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28602948/emerging-strategies-for-antimicrobial-drug-delivery-to-the-ocular-surface-implications-for-infectious-keratitis
#19
REVIEW
Ajay Sharma, Jonathan Taniguchi
Infectious keratitis is a medical emergency that can cause severe visual morbidity if not treated promptly. Depending upon the causative microorganism, effective management of infectious keratitis requires frequent application of antibacterial, antifungal, or antiviral eye drops, which may have low bioavailability, undesirable side effects, and poor patient compliance. Ocular formulations of antimicrobials that can increase corneal permeation and provide extended presence on ocular surface are being developed...
June 7, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28602547/non-invasive-objective-and-contemporary-methods-for-measuring-ocular-surface-inflammation-in-soft-contact-lens-wearers-a-review
#20
REVIEW
Cecilia Chao, Kathryn Richdale, Isabelle Jalbert, Kim Doung, Moneisha Gokhale
Contact lens wear is one of the primary risk factors for the development of ocular surface inflammatory events. The purpose of this review is to examine and summarize existing knowledge on the mechanisms of contact lens related ocular surface inflammation and the evidence for the effectiveness of current objective methods to measure ocular surface inflammation. Contact lens wear is postulated to trigger an inflammatory response on the ocular surface due to mechanical, chemical, hypoxic stress, or by the introduction of microbes and their toxins...
June 8, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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