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https://www.readbyqxmd.com/read/29924447/evaluation-of-tlr2-tlr4-and-tollip-polymorphisms-for-their-role-in-tuberculosis-susceptibility
#1
Shouquan Wu, Weiwei Huang, Dan Wang, Yu Wang, Minggui Wang, Miaomiao Zhang, Jian-Qing He
Previous studies indicated that single-nucleotide polymorphisms (SNPs) of genes coding for toll-like receptors (TLRs) and toll-interacting protein (TOLLIP) may be involved in the pathogenesis of pulmonary tuberculosis (PTB). This study was designed to investigate potential associations between the polymorphisms in TLR2, TLR4, and TOLLIP and susceptibility to latent tuberculosis infection (LTBI) or subsequent PTB in a Chinese Han population. A total of 209 PTB and 201 LTBI patients and 204 healthy control subjects (HCS) were enrolled in our study...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29923534/a-cohort-study-on-risk-factors-for-preterm-births-in-rural-gujarat
#2
Poonam Trivedi, Deepak Saxena, Tapasvi Puwar, Shital Savaliya, Parthasarathi Ganguly
Background: Prematurity is one of the leading causes of neonatal and under-five mortalities globally and also in India. It is an important determinant of short- and long-term morbidities in infants and children. Unfortunately, risk factors of majority of preterm births (PTBs) remain unexplained which calls for appropriate action. There is a dearth of community-based research on PTB and its risk factors, especially in high burden countries like India. Objectives: The objective of the study was to explore different risk factors for PTB...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29922937/evaluation-of-a-multilevel-intervention-to-reduce-preterm-birth-among-black-women-in-newark-new-jersey-a-controlled-interrupted-time-series-analysis
#3
Teresa Janevic, Jennifer A Hutcheon, Norm Hess, Laurie Navin, Elizabeth A Howell, Lisa Gittens-Williams
Objective To evaluate the effectiveness of a multilevel intervention, Healthy Babies are Worth the Wait (HBWW), in reducing preterm birth (PTB) and very preterm birth (VPTB) among black women in Newark, NJ. Methods HBWW is a program linking the local March of Dimes office, providers, community-based organizations, and public health institutions to increase uptake of evidence based preterm birth interventions. We used birth certificate data before (2009-2011) and after (2012-2015) the introduction of HBWW in Newark...
June 19, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29920812/can-previous-preterm-birth-classification-influence-treatment-of-short-cervix-in-a-subsequent-pregnancy-comparison-of-vaginal-progesterone-and-arabin-pessary
#4
Angharad Care, Bertram Muller-Myhsok, Elena Olearo, Tullia Todros, Javier Caradeux, Maria Goya, Montse Palacio, Elena Carreras, Zarko Alfirevic
OBJECTIVE: The aim of this study was to investigate whether the classification of a previous spontaneous preterm birth (sPTB) into; i) sPTB or ii) PPROM, impacts the efficacy of cervical pessary or vaginal progesterone in pregnant women with short cervix on transvaginal ultrasound. METHODS: Four European hospitals using pessary or vaginal progesterone as a primary PTB prevention treatment for asymptomatic high-risk singletons with a short cervix, provided retrospective cohort data...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29913333/spontaneous-and-iatrogenic-preterm-birth-rates-among-unselected-women-in-three-consecutive-pregnancies
#5
Esme I Kamphuis, Anita C J Ravelli, Bouchra Koullali, Brenda Kazemier, Christianne J M de Groot, Ben Willem J Mol
OBJECTIVE: To assess the risk of sPTB and iPTB in women with three consecutive singleton pregnancies and the impact of the outcome of the 1st and 2nd pregnancy on the (recurrent) PTB risk in the 3rd pregnancy. STUDY DESIGN: A nationwide retrospective cohort study using the population based longitudinal linked dataset of the Netherlands. We included all nulliparous women with three consecutive singleton pregnancies ending between 22 and 44 weeks of gestation between 1999 and 2009...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#6
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29911323/regulation-of-p38-mitogen-activated-kinase-mediated-fetal-membrane-senescence-by-statins
#7
Martina T Ayad, Brandie D Taylor, Ramkumar Menon
PROBLEM: Oxidative stress (OS)-induced, p38 mitogen-activated protein kinase (p38MAPK)-mediated chorioamniotic senescence and inflammation (senescence-associated secretory phenotype [SASP]) are associated with parturition. In response to OS-inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK-mediated senescence and SASP...
June 17, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29906287/a-combination-of-quantitative-and-qualitative-methods-in-investigating-risk-factors-for-lost-to-follow-up-for-tuberculosis-treatment-in-japan-are-physicians-and-nurses-at-a-particular-risk
#8
Lisa Kawatsu, Kazuhiro Uchimura, Akihiro Ohkado, Seiya Kato
BACKGROUND: The treatment success rate of pulmonary tuberculosis (PTB) patients aged 64 years and below in Japan, a tuberculosis (TB) middle-burden country with a notification of 13.9 per 100,000 populations in 2016, has been fluctuating around 70% for some years. In order to improve treatment outcome, it is critical to address those lost to follow-up (LTFU). The objective of the study therefore was to describe the characteristics of, and analyze the risk factors for those LTFU among pulmonary TB patients aged between 15 and 64, and discuss policy implications...
2018: PloS One
https://www.readbyqxmd.com/read/29905550/-seasonal-variation-of-microvolt-t-wave-alternans-in-patients-with-cardiovascular-disease-and-healthy-subjects
#9
Gh Halabi, N Bulanova, S Aleksandrova, G Ivanov, M Aleksandrova
Objective - to access seasonal variation of microvolt T-wave alternans of ECG dispersion mapping in patients with cardiovascular disease and healthy subjects. ECG data of the three groups of healthy subjects have been compared: inhabitants of Beirut, Lebanon (n=51), inhabitants of Moscow, Russia (n=94) and ECG data of healthy subjects (n=44) from the testing ECG database of the PTB - The National Metrology Institute of Germany as well as a group of patients with cardiovascular disease (n=138), inhabitants of Beirut, Lebanon...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904101/evaluating-the-impact-of-transmission-mode-calibration-level-and-farmer-compliance-in-simulation-models-of-paratuberculosis-in-dairy-herds
#10
Carsten Kirkeby, Kaare Græsbøll, Tariq Halasa
Simulation models can predict the outcome of different strategies for the control and eradication of paratuberculosis (PTB) in dairy herds. Two main transmission modes have previously been used to simulate the spread of PTB: direct (contact between animals) and indirect (through the environment). In addition, previous models were calibrated to either low or high within-herd prevalence levels, which we refer to as normal and low hygiene levels, respectively. We simulated both direct and indirect transmission with the same model in both normal and low hygiene level scenarios...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29893198/utilization-and-clinical-value-of-diagnostic-modalities-for-tuberculosis-in-a-high-hiv-prevalence-setting
#11
Stephanie Gati, Rhoda Chetty, Douglas Wilson, Jacqueline M Achkar
Human immunodeficiency virus (HIV) infection is a major risk factor for the development of active tuberculosis (TB), one of the deadliest infectious diseases globally. The high mortality associated with the disease can be reduced by early diagnosis and prompt antituberculous treatment initiation. Facilities in TB-endemic regions are increasing the use of nucleic acid amplification (e.g., GeneXpert), which provides rapid results but may have suboptimal sensitivity in HIV-associated TB. Our objective was to evaluate the current practices for TB diagnosis at Edendale Hospital, a large regional hospital in KwaZulu-Natal, South Africa-a TB-endemic region with high HIV prevalence...
June 11, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29891147/temporal-analysis-of-the-interference-caused-by-paratuberculosis-vaccination-on-the-tuberculosis-diagnostic-tests-in-goats
#12
Álvaro Roy, José Antonio Infantes-Lorenzo, Juan Carlos Blázquez, Ángel Venteo, Francisco José Mayoral, Mercedes Domínguez, Inmaculada Moreno, Beatriz Romero, Lucía de Juan, Anna Grau, Lucas Domínguez, Javier Bezos
Vaccination against paratuberculosis (PTB) in goats is a cost-effective control strategy, and is also effective as regards preventing the onset of clinical cases. However, it causes interference in the diagnostic tests used in the control of tuberculosis (TB). A group of 99 goats from a herd with no history of TB or PTB infection was vaccinated against PTB at seven months of age. They then underwent consecutive intradermal tests [single (SIT) and comparative (CIT) intradermal tuberculin tests), interferon-gamma release assays (IGRA) and two serological tests (p22_CE and DR-ELISA) every three months, until the interference disappeared...
August 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29888256/genetic-polymorphisms-of-il1b-il6-and-tnf%C3%AE-in-a-chinese-han-population-with-pulmonary-tuberculosis
#13
Shouquan Wu, Yu Wang, Miaomiao Zhang, Saurav S Shrestha, Minggui Wang, Jian-Qing He
Background: The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood. Previous studies have shown that cytokine gene polymorphisms were associated with PTB. Objectives: In this study, we have investigated the relationship between ILB , IL6, and TNFα polymorphisms and a predisposition to Mycobacterium tuberculosis (MTB) infection and PTB. Methods: A total of 209 cases of PTB, 201 subjects with latent TB infection (LTBI), and 204 healthy controls (HCS) were included in this study...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29884241/analysis-of-tuberculosis-treatment-outcomes-among-pulmonary-tuberculosis-patients-in-bahawalpur-pakistan
#14
Muhammad Atif, Zainab Anwar, Razia Kaneez Fatima, Iram Malik, Saima Asghar, Shane Scahill
OBJECTIVE: Monitoring tuberculosis treatment outcomes and understanding the reasons for unsuccessful treatment are important indicators for evaluating the performance of the national tuberculosis control program. The aim of this study was to evaluate the treatment outcomes among pulmonary TB (PTB) patients and identify the predictors of unsuccessful treatment outcome. RESULTS: Treatment success rate of 67.8% among new and retreatment PTB patients and 69% in new smear positive PTB patients was observed...
June 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29883901/the-age-related-patterns-of-preterm-birth-among-urban-african-american-and-non-latina-white-mothers-the-effect-of-paternal-involvement
#15
Shayna D Hibbs, Kristin M Rankin, Carla DeSisto, James W Collins
Few studies have examined contributions of paternal factors to birth outcomes. Weathering is a pattern of increasing rates of adverse birth outcome with increasing maternal age. This study evaluates for an association between paternal involvement and weathering in the context of preterm birth (PTB, <37 weeks) among non-Hispanic African-American and non-Hispanic White women with and without lifelong exposure to neighborhood poverty. Using the Illinois transgenerational dataset with appended US census income information of infants (1989-1991) and their mothers (1956-1976), we compared infants of women by degree of paternal involvement: married, unmarried with father named on birth certificate, and unnamed father...
May 30, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29880304/a-new-reference-type-ionization-chamber-with-direction-independent-response-for-use-in-small-field-photon-beam-dosimetry-an-experimental-and-monte-carlo-study
#16
Björn Delfs, Ralf-Peter Kapsch, Ndimofor Chofor, Hui Khee Looe, Dietrich Harder, Björn Poppe
The frequently applied narrow and non-standard transverse dose profiles of intensity modulated photon-beam radiotherapy, lacking lateral secondary electron equilibrium, require the use of high-resolution dosimetry detectors, and small air-filled detectors are recommended as the reference detectors for cross-calibration of the high-resolution detectors. The present study focuses on the dosimetric properties of a novel cylindrical ionization chamber, the PTW Semiflex 3D 31021. The chamber's effective point of measurement was found to lie at (0...
June 4, 2018: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29871780/diminished-circulating-plasma-and-elevated-lymph-node-culture-supernatant-levels-of-il-10-family-cytokines-in-tuberculous-lymphadenitis
#17
Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Dhanaraj Baskaran, Syed Hissar, Basavegowdanadoddi M Shrinivasa, Rathinam Sridhar, Subash Babu
BACKGROUND: IL-10 family cytokines are associated with the host immune response to pulmonary tuberculosis (PTB), but their association with host response in tuberculous lymphadenitis (TBL) is not known. METHODS: Hence, we examined the circulating levels of the whole panel of IL-10 family cytokines in TBL (n = 44) and compared them to the levels in PTB (n = 44) and healthy control (HC, n = 44) individuals. We also assessed the pre and post-treatment cytokine levels in TBL individuals following the completion of anti-tuberculosis treatment (ATT)...
June 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29868246/comparison-of-serum-and-cervical-cytokine-levels-throughout-pregnancy-between-preterm-and-term-births
#18
Kristin Ashford, Niraj R Chavan, Amanda T Wiggins, Molly Malany Sayre, Andrea McCubbin, Agatha S Critchfield, John O'Brien
Objective  To assess differences in cytokine levels in cervicovaginal fluid (CVF) and serum across trimesters between women with preterm births (PTBs) and full-term births. Study Design  This multicenter study enrolled 302 women with a singleton gestation. CVF and serum cytokines, interleukin 1α (IL-1α), IL-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and matrix metalloproteinase (MMP)-8, were measured. Women with at least one cytokine assessment and noted PTB status in their medical record were retained in the study ( N  = 272)...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29867970/meta-analysis-of-maternal-and-fetal-transcriptomic-data-elucidates-the-role-of-adaptive-and-innate-immunity-in-preterm-birth
#19
Bianca Vora, Aolin Wang, Idit Kosti, Hongtai Huang, Ishan Paranjpe, Tracey J Woodruff, Tippi MacKenzie, Marina Sirota
Preterm birth (PTB) is the leading cause of newborn deaths around the world. Spontaneous preterm birth (sPTB) accounts for two-thirds of all PTBs; however, there remains an unmet need of detecting and preventing sPTB. Although the dysregulation of the immune system has been implicated in various studies, small sizes and irreproducibility of results have limited identification of its role. Here, we present a cross-study meta-analysis to evaluate genome-wide differential gene expression signals in sPTB. A comprehensive search of the NIH genomic database for studies related to sPTB with maternal whole blood samples resulted in data from three separate studies consisting of 339 samples...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29862955/diabetes-and-pre-diabetes-among-household-contacts-of-tuberculosis-patients-in-india-is-it-time-to-screen-them-all
#20
S V B Y Shivakumar, P Chandrasekaran, A M V Kumar, M Paradkar, K Dhanasekaran, N Suryavarshini, B Thomas, R Kohli, K Thiruvengadam, V Kulkarni, L E Hannah, G N Sivaramakrishnan, N Pradhan, C Dolla, A Gupte, G Ramachandran, A DeLuca, S Meshram, R Bhardawaj, R C Bollinger, J Golub, K Selvaraj, N Gupte, S Swaminathan, V Mave, A Gupta
SETTING: Pre-diabetes mellitus (pre-DM) and DM increase the risk of developing tuberculosis (TB). Screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing TB and improve DM management. OBJECTIVE: To measure the prevalence of pre-DM/DM and associated factors among the adult household contacts (HHCs) of pulmonary TB patients. METHODS: Between August 2014 and May 2017, adult HHCs of newly diagnosed adult PTB patients in Pune and Chennai, India, had single blood samples tested for glycosylated haemoglobin (HbA1c) at enrolment...
June 1, 2018: International Journal of Tuberculosis and Lung Disease
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