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https://www.readbyqxmd.com/read/29453318/integration-of-distinct-shca-signaling-complexes-promotes-breast-tumor-growth-and-tyrosine-kinase-inhibitor-resistance
#1
Jacqueline R Ha, Ryuhjin Ahn, Harvey W Smith, Valerie Sabourin, Steven Hėbert, Eduardo Cepeda Cañedo, Young Kyuen Im, Claudia Kleinman, William J Muller, Josie Ursini-Siegel
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. Receptor tyrosine kinases (RTKs), such as ErbB2, engage the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29447339/integrated-microrna-and-mrna-network-analysis-of-the-human-myometrial-transcriptome-in-the-transition-from-quiescence-to-labor
#2
William E Ackerman, Irina A Buhimschi, Douglas Brubaker, Sean Maxwell, Kara M Rood, Mark R Chance, Hongwu Jing, Sam Mesiano, Catalin S Buhimschi
We conducted integrated transcriptomics network analyses of miRNA and mRNA interactions in human myometrium to identify novel molecular candidates potentially involved in human parturition. Myometrial biopsies were collected from women undergoing primary Cesarean deliveries in well-characterized clinical scenarios: 1) spontaneous term labor (TL, n = 5); 2) term non-labor (TNL, n = 5); 3) spontaneous preterm birth (PTB) with histologic chorioamnionitis (PTB-HCA, n = 5); and 4) indicated PTB non-labor (PTB-NL, n = 5)...
February 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29443441/cumulative-live-birth-rates-and-perinatal-outcomes-with-the-use-of-time-lapse-imaging-incubators-for-embryo-culture-a-retrospective-cohort-study-of-1882-art-cycles
#3
Mariano Mascarenhas, Sarah J Fox, Karen Thompson, Adam H Balen
OBJECTIVE: Comparison of live birth rates and the perinatal outcomes after fresh and frozen embryo transfer between time lapse imaging (TLI) and standard culture (SC) incubators. DESIGN: Retrospective cohort study. SETTING: A single tertiary level IVF unit. POPULATION: Women undergoing IVF between January 2014 and October 2015. METHODS: Comparison was done between 1064 IVF cycles using TLI (TLI cycles) and 818 IVF cycles using SC (SC cycles)...
February 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29442278/racial-ethnic-inequities-in-low-birth-weight-and-preterm-birth-the-role-of-multiple-forms-of-stress
#4
Joanna Almeida, Laia Bécares, Kristin Erbetta, Vani R Bettegowda, Indu B Ahluwalia
Introduction Racial/ethnic inequities in low birth weight (LBW) and preterm birth (PTB) persist in the United States. Research has identified numerous risk factors for adverse birth outcomes; however, they do not fully explain the occurrence of, or inequalities in PTB/LBW. Stress has been proposed as one explanation for differences in LBW and PTB by race/ethnicity. Methods Using the Pregnancy Risk Assessment Monitoring System (PRAMS) data from 2012 to 2013 for 21 states and one city (n = 15,915) we used Poisson regression to estimate the association between acute, financial and relationship stressors and LBW and PTB, and to examine the contribution of these stressors individually and simultaneously to racial/ethnic differences in LBW and PTB...
February 13, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29439621/biofluid-metabolomics-in-preterm-birth-research
#5
Ana M Gil, Daniela Duarte
This article presents an account of the research carried out so far in the use of metabolomics to find biomarkers of preterm birth (PTB) in fetal, maternal, and newborn biofluids. Metabolomic studies have employed mainly nuclear magnetic resonance spectroscopy or mass spectrometry-based methodologies to analyze, on one hand, prenatal biofluids (amniotic fluid, maternal urine/maternal blood, cervicovaginal fluid) to identify predictive biomarkers of PTB, and on the other hand, biofluids collected at or after birth (amniotic fluid, umbilical cord blood, newborn urine, and newborn blood, maternal blood, or breast milk) to assess and follow up the health status of PTB babies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29434245/galectin-3-plays-an-important-role-in-preterm-birth-caused-by-dental-infection-of-porphyromonas-gingivalis
#6
Mutsumi Miyauchi, Min Ao, Hisako Furusho, Chanbora Chea, Atsuhiro Nagasaki, Shinnichi Sakamoto, Toshinori Ando, Toshihiro Inubushi, Katsuyuki Kozai, Takashi Takata
Dental infection is risk for preterm birth (PTB) through unclear mechanisms. We established a dental infection-induced PTB mouse model, in which Porphyromonas gingivalis (P.g.) induced PTB by 2 days. We analysed pathogenic factors contributing to PTB and their effects on trophoblasts in vitro. TNF-α, IL-8, and COX-2 were upregulated in P.g.-infected placenta. Galectin-3 (Gal-3), an immune regulator, was significantly upregulated in placenta, amniotic fluid, and serum. In vitro, P.g.-lipopolysaccharide (P.g...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433978/deconstructing-a-disparity-explaining-excess-preterm-birth-among-u-s-born-black-women
#7
Carla L DeSisto, Ashley H Hirai, James W Collins, Kristin M Rankin
PURPOSE: To determine components of excess preterm birth (PTB) rates for U.S.-born black women relative to both foreign-born black women and U.S.-born white women attributable to differences in observed sociodemographic, behavioral, and medical risk factors. METHODS: Using the 2013 U.S. natality files, we used Oaxaca-Blinder decomposition on the absolute scale to estimate the contribution of the group differences in the prevalence of PTB predictors between U.S...
February 2, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29433021/residential-green-space-and-birth-outcomes-in-a-coastal-setting
#8
Kimberly B Glazer, Melissa N Eliot, Valery A Danilack, Lynn Carlson, Maureen G Phipps, Payam Dadvand, David A Savitz, Gregory A Wellenius
BACKGROUND: Residential green space may improve birth outcomes, with prior studies reporting higher birthweight among infants of women living in greener areas. However, results from studies evaluating associations between green space and preterm birth have been mixed. Further, the potential influence of residential proximity to water, or 'blue space', on health has not previously been evaluated. OBJECTIVES: To evaluate associations between green and blue space and birth outcomes in a coastal area of the northeastern United States...
February 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29431293/il-17a-g197g-association-between-nox-and-gestational-age-in-a-south-african-birth-cohort
#9
P Nansook, R N Naidoo, S Muttoo, K Asharam, P Ramkaran, A Phulukdaree, A A Chuturgoon
Interleukin (IL-)17A, plays a role in pathogenic defence, but is implicated in chronic inflammatory diseases, and has recently been associated with variable pregnancy outcomes. We investigated the role of maternal IL-17-[G197A]-specific effects of third-trimester IL-17 mRNA expression, NOx exposure levels and other variables on gestational age, in the Mother and Child in the Environment (MACE) birth cohort in South Africa. A total of 327 participants were genotyped for IL-17-[G197A] by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP)...
February 12, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29430189/the-correlation-between-ct-features-and-glycosylated-hemoglobin-level-in-patients-with-t2dm-complicated-with-primary-pulmonary-tuberculosis
#10
Li-Li Xia, Su-Fen Li, Kan Shao, Xin Zhang, Shan Huang
To investigate the correlation between computed tomography (CT) features and glycosylated hemoglobin (HbAlc) levels in patients with type 2 diabetes mellitus (T2DM) complicated with primary pulmonary tuberculosis (PTB). One hundred and eighty untreated PTB patients complicated with T2DM were selected. Based on the HbAlc level, the patients were divided into three groups: HbAlc level <7% (Group I: 32 patients), 7%-9% (Group II: 48 patients), and >9% (Group III: 100 patients). The changes of CT manifestations and HbAlc were analyzed after TB and T2DM treatment...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29428408/evaluating-the-diagnostic-accuracy-of-the-xpert%C3%A2-mtb-rif-assay-on-bronchoalveolar-lavage-fluid-a-retrospective-study
#11
Yanjun Lu, Yaowu Zhu, Na Shen, Lei Tian, Ziyong Sun
OBJECTIVE: Limited data on the diagnostic accuracy of the Xpert® MTB/RIF assay using bronchoalveolar lavage fluid in patients with suspected pulmonary tuberculosis (PTB) have been reported in China. Therefore, we designed a retrospective study to evaluate the diagnostic accuracy of this assay. METHODS: Clinical, radiological, and microbiological characteristics of 238 PTB-suspected patients were retrospectively reviewed. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for the diagnosis of active PTB were calculated for the Xpert® MTB/RIF assay using TB culture or final diagnosis based on clinical and radiological evaluation as a reference standard...
February 8, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29424965/prevalence-and-risk-factors-of-drug-resistant-extrapulmonary-tuberculosis
#12
Viboon Boonsarngsuk, Khattiya Mangkang, Pitak Santinirand
BACKGROUND: Physicians are usually aware of the occurrence of drug-resistant (DR) pulmonary tuberculosis (PTB), but lack concern about DR-extrapulmonary TB (EPTB). Data regarding the prevalence and risk factors of DR-EPTB remain limited. OBJECTIVES: To determine the prevalence and risk factors of DR-EPTB. METHODS: A retrospective study was performed in patients who had culture-proven Mycobacterium tuberculosis (MTB) from various specimens between January 2013 and December 2015...
February 9, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29416328/emphysema-and-bronchiectasis-in-copd-patients-with-previous-pulmonary-tuberculosis-computed-tomography-features-and-clinical-implications
#13
Jianmin Jin, Shuling Li, Wenling Yu, Xiaofang Liu, Yongchang Sun
Background: Pulmonary tuberculosis (PTB) is a risk factor for COPD, but the clinical characteristics and the chest imaging features (emphysema and bronchiectasis) of COPD with previous PTB have not been studied well. Methods: The presence, distribution, and severity of emphysema and bronchiectasis in COPD patients with and without previous PTB were evaluated by high-resolution computed tomography (HRCT) and compared. Demographic data, respiratory symptoms, lung function, and sputum culture of Pseudomonas aeruginosa were also compared between patients with and without previous PTB...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29415650/conservation-of-polypyrimidine-tract-binding-proteins-and-their-putative-target-rnas-in-several-storage-root-crops
#14
Kirtikumar R Kondhare, Amit Kumar, David J Hannapel, Anjan K Banerjee
BACKGROUND: Polypyrimidine-tract binding proteins (PTBs) are ubiquitous RNA-binding proteins in plants and animals that play diverse role in RNA metabolic processes. PTB proteins bind to target RNAs through motifs rich in cytosine/uracil residues to fine-tune transcript metabolism. Among tuber and root crops, potato has been widely studied to understand the mobile signals that activate tuber development. Potato PTBs, designated as StPTB1 and StPTB6, function in a long-distance transport system by binding to specific mRNAs (StBEL5 and POTH1) to stabilize them and facilitate their movement from leaf to stolon, the site of tuber induction, where they activate tuber and root growth...
February 7, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29415593/maternal-obesity-fish-intake-and-recurrent-spontaneous-preterm-birth
#15
Marcela C Smid, Alison M Stuebe, Tracy A Manuck, Sarbattama Sen
OBJECTIVE: Moderate fish intake in early pregnancy is associated with decreased risk of preterm birth (PTB). Obesity during pregnancy is characterized by inflammation and insufficiency of essential fatty acids. The objective of this study was to measure the association between fish intake during pregnancy and risk of recurrent spontaneous (s)PTB among lean, overweight and obese women. DESIGN: This is secondary analysis of a randomized controlled trial of omega-3 fatty acid supplementation for recurrent PTB prevention, 2005-2006...
February 7, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29415469/circsmarca5-inhibits-migration-of-glioblastoma-multiforme-cells-by-regulating-a-molecular-axis-involving-splicing-factors-srsf1-srsf3-ptb
#16
Davide Barbagallo, Angela Caponnetto, Matilde Cirnigliaro, Duilia Brex, Cristina Barbagallo, Floriana D'Angeli, Antonio Morrone, Rosario Caltabiano, Giuseppe Maria Barbagallo, Marco Ragusa, Cinzia Di Pietro, Thomas Birkballe Hansen, Michele Purrello
Circular RNAs (circRNAs) have recently emerged as a new class of RNAs, highly enriched in the brain and very stable within cells, exosomes and body fluids. To analyze their involvement in glioblastoma multiforme (GBM) pathogenesis, we assayed the expression of twelve circRNAs, physiologically enriched in several regions of the brain, through real-time PCR in a cohort of fifty-six GBM patient biopsies and seven normal brain parenchymas. We focused on hsa_circ_0001445 (circSMARCA5): it was significantly downregulated in GBM biopsies as compared to normal brain tissues (p-value < 0...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29408625/maternal-and-neonatal-irisin-precursor-gene-fndc5-polymorphism-is-associated-with-preterm-birth
#17
Hagit Salem, Yekaterina Yatchenko, Mariana Anosov, Talya Rosenfeld, Gheona Altarescu, Sorina Grisaru-Granovsky, Ruth Birk
Irisin is a novel secreted myokine, encoded by the fibronectin type III domain-containing protein 5 (FNDC5) precursor gene. Irisin plays a role in the female reproductive system in pregnancy and in embryonic development, and is associated with fetal size. It is expressed in the ovary, placenta and neonatal cord serum. We studied whether maternal and neonatal FNDC5 genetic polymorphisms are associated with preterm birth (PTB). Blood for DNA analysis was collected from Israeli mothers (n = 315) and from umbilical veins of their respected idiopathic preterm (24-36 weeks) and control term (>37 weeks) newborns (n = 161)...
January 30, 2018: Gene
https://www.readbyqxmd.com/read/29406784/resistance-training-recovers-attenuated-appl1-expression-and-improves-insulin-induced-akt-signal-activation-in-skeletal-muscle-of-type-2-diabetic-rats
#18
Kohei Kido, Satoru Ato, Takumi Yokokawa, Koji Sato, Satoshi Fujita
Adapter protein containing PH domain, PTB domain, and leucine zipper motif 1 (APPL1) has been reported as a positive regulator of insulin-stimulated Akt activation. The expression of APPL1 is reduced in skeletal muscles of type 2 diabetic (T2D) animals, implying that APPL1 may be an important factor affecting insulin sensitivity. However, the regulation of APPL1 expression and the physiological interventions modulating these effects are unclear. Accordingly, we first confirmed that APPL1 expression and Akt phosphorylation were significantly attenuated in skeletal muscles of T2D rats...
February 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29406317/electrohysterography-in-the-diagnosis-of-preterm-birth-a-review
#19
Javier Garcia-Casado, Yiyao Ye-Lin, Gema Prats-Boluda, Javier Mas-Cabo, José Alberola-Rubio, Alfredo Perales
Preterm birth (PTB) is one of the most common and serious complications in pregnancy. About 15 million preterm neonates are born every year, with ratios of 10-15% of total births. In industrialized countries, preterm delivery is responsible for 70% of mortality and 75% of morbidity in the neonatal period. Diagnostic means for its timely risk assessment are lacking and the underlying physiological mechanisms are unclear. Surface recording of the uterine myoelectrical activity (electrohysterogram, EHG) has emerged as a better uterine dynamics monitoring technique than traditional surface pressure recordings and provides information on the condition of uterine muscle in different obstetrical scenarios with the emphasis on predicting preterm deliveries...
February 6, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29405967/identification-of-haptoglobin-switch-on-status-in-archived-placental-specimens-indicates-antenatal-exposure-to-inflammation-and-potential-participation-of-the-fetus-in-triggering-preterm-birth
#20
Megan E McCarthy, Catalin S Buhimschi, John T Hardy, Antonette T Dulay, Christine A Laky, Mert-Ozan Bahtyiar, Ramesha Papanna, Guomao Zhao, Irina A Buhimschi
OBJECTIVE: Haptoglobin (Hp) has key immunoregulatory roles that vary with phenotype (Hp1-1, Hp2-1, Hp2-2). Cord blood Hp expression is switched-off in the normal fetus. We hypothesized that in the setting of fetal inflammation placenta becomes inundated with Hp of fetal origin that in turn modulates the output of PGE 2 and MMP-9 in a phenotype dependent manner. METHODS: Placentas from 40 pregnancies complicated by preterm birth (PTB) (<37 weeks), without (n = 15) or with (n = 25) intra-amniotic infection and histological chorioamnionitis (HCA) were scored for intensity of Hp immunostaining...
February 2018: Placenta
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