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Chelsea Doktorchik, Shahirose Premji, Donna Slater, Tyler Williamson, Suzanne Tough, Scott Patten
BACKGROUND: To determine whether changes in anxiety and depression during pregnancy influence the risk of having a preterm birth (PTB), and whether chronic stress modifies this relationship. METHODS: The data source for the current study is the All Our Babies prospective cohort (AOB). Anxiety and depression were measured at 17-24 weeks and again at 32-36 weeks' gestation using the Spielberg State Anxiety Scale and the Edinburgh Postnatal Depression Scale, respectively...
October 2, 2017: Journal of Affective Disorders
Xinyu Yang, Jia-Bao Wu, Ying Liu, Yanqing Xiong, Ping Ji, Shu-Jun Wang, Yingying Chen, Guo-Ping Zhao, Shui-Hua Lu, Ying Wang
OBJECTIVES: It remains necessary and urgent to search for novel mycobacterial antigens to increase the sensitivity and specificity for tuberculosis (TB) diagnosis and latent TB infection (LTBI) screening. Antigens capable of inducing strong immune responses during Mycobacterium tuberculosis (M.tb) infection would be good candidates. METHODS: Cellular responses specific to M.tb derived bacterioferritin B (BfrB) were assessed by IFN-γ ELISPOT in three human cohorts, including healthy controls (HCs), LTBI population and pulmonary TB (PTB) patients...
December 2017: Tuberculosis
E G Yukihara, M S Akselrod, V Fomenko, J Harrison, M Million, F Assenmacher, A Stabilini, K Meier
The objective of this study was to compare a neutron dosimetry system based on polyallyl diglycol carbonate (PADC) detectors with a new system based on Al2O3:C,Mg fluorescence nuclear track detectors (FNTD). The irradiations, performed as part of an intercomparison organized by the Physikalisch-Technische Bundesanstalt (PTB), Germany, were on a PMMA phantom with 252Cf or 241Am-Be source, usually with the phantom surface perpendicular to the radiation beam (0° angle), and with Hp(10) values between 0.3 and 7 mSv...
September 23, 2017: Radiation Protection Dosimetry
Ana Costa-Veiga, Teodoro Briz, Carla Nunes
Background: Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out)...
October 3, 2017: European Journal of Public Health
Yangqian Jiang, Wei Xia, Bin Zhang, Xinyun Pan, Wenyu Liu, Shuna Jin, Wenqian Huo, Hongxiu Liu, Yang Peng, Xiaojie Sun, Hongling Zhang, Aifen Zhou, Shunqing Xu, Yuanyuan Li
Thallium (Tl) is a well-recognized hazardous toxic heavy metal that has been reported to have embryotoxicity and fetotoxicity. However, little is known about its association with preterm birth (PTB) in humans. We aimed to evaluate the predictors of Tl exposure and assessed its relation with PTB. The study population included 7173 mother-infant pairs from a birth cohort in Wuhan, China. Predictors of Tl concentrations were explored using linear regression analyses, and associations of Tl exposure with risk of PTB or gestational age at birth were estimated using logistic regression or generalized linear models...
October 12, 2017: Environmental Pollution
Xian-Hua Wang, Ai-Guo Ma, Xiu-Xia Han, Lei Chen, Hui Liang, Aishan-Litifu, Abudumijit-Ablez, Feng Xue
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene and additional gene- gene and gene- type 2 diabetes mellitus (T2DM) interaction with pulmonary tuberculosis (PTB) risk in Chinese Uygur population. METHODS: A total of 722 participants (186 males, 536 females) were selected, including 360 PTB patients and 362 control participants. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and T2DM...
September 12, 2017: Oncotarget
Clarence R Manuel, Charles R Ashby, Sandra E Reznik
BACKGROUND: Preterm birth (PTB) is a multifactorial syndrome occurring before the 37th week of full-term pregnancy [1]. Babies delivered preterm experience short-term and long-term complications affecting multiple organ systems, and serious maternal complications include hemorrhage and infection. Each year, an estimated 15 million babies are born preterm, and complications from prematurity are the leading cause of death among children up to 5 years of age [2]. With another increase in PTB rates over the last several years, the United States continues to have the highest incidence of any industrialized country [3]...
October 12, 2017: Current Pharmaceutical Design
Paula Braveman, Katherine Heck, Susan Egerter, Tyan Parker Dominguez, Christine Rinki, Kristen S Marchi, Michael Curtis
OBJECTIVES: The causes of the large and persistent Black-White disparity in preterm birth (PTB) are unknown. It is biologically plausible that chronic stress across a woman's life course could be a contributor. Prior research suggests that chronic worry about experiencing racial discrimination could affect PTB through neuroendocrine, vascular, or immune mechanisms involved in both responses to stress and the initiation of labor. This study aimed to examine the role of chronic worry about racial discrimination in Black-White disparities in PTB...
2017: PloS One
Katharina da Silva Lopes, Erika Ota, Prakash Shakya, Amarjargal Dagvadorj, Olukunmi Omobolanle Balogun, Juan Pablo Peña-Rosas, Luz Maria De-Regil, Rintaro Mori
INTRODUCTION: Low birth weight (LBW, birth weight less than 2500 g) is associated with infant mortality and childhood morbidity. Poor maternal nutritional status is one of several contributing factors to LBW. We systematically reviewed the evidence for nutrition-specific (addressing the immediate determinants of nutrition) and nutrition-sensitive (addressing the underlying cause of undernutrition) interventions to reduce the risk of LBW and/or its components: preterm birth (PTB) and small-for-gestational age (SGA)...
2017: BMJ Global Health
K Chavalertsakul, V Boonsarngsuk, S Saengsri, P Santanirand
<h2>SETTING:</h2>A tertiary referral hospital in Bangkok, Thailand.<h2>OBJECTIVES:</h2>To evaluate the efficacy of a bronchoalveolar lavage fluid (BALF) tuberculosis (TB) polymerase chain reaction (PCR) assay for the diagnosis of sputum smear-negative pulmonary TB (PTB) and the usefulness of a drug-resistant (DR) TB-PCR assay compared with standard drug susceptibility testing (DST).<h2>DESIGN:</h2>BALF samples from 918 patients with acid-fast bacilli (AFB) negative sputum smears who underwent bronchoscopy for diagnostic evaluations of pulmonary diseases were prospectively determined for specific genetic elements of TB using the Anyplex(TM) MTB/NTM Real-Time Detection kit...
October 9, 2017: International Journal of Tuberculosis and Lung Disease
Jitendra P Nandre, Samadhan R Patil, Suban K Sahoo, Chullikkattil P Pradeep, Andrei Churakov, Fabiao Yu, Lingxin Chen, Carl Redshaw, Ashok A Patil, Umesh D Patil
The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography. The metal ion sensing ability of PTB-1 was explored by various experimental (naked-eye, UV-Vis, fluorescence, mass spectrometry and (1)H NMR spectroscopy) and theoretical (B3LYP/6-31G**/LANL2DZ) methods. PTB-1 exhibited a highly selective naked-eye detectable color change from colorless to dark brown and UV-Vis spectral changes for the detection of Ag(+) with a detection limit of 3...
October 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Suk-Joo Choi
Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pregnancies, ethnicity, smoking, uterine anomaly and history of curettage or cervical conization. Among these risk factors, history of PTB, and short CL are the most important predictive factors...
September 2017: Obstetrics & Gynecology Science
James Kapisi, Abel Kakuru, Prasanna Jagannathan, Mary K Muhindo, Paul Natureeba, Patricia Awori, Miriam Nakalembe, Richard Ssekitoleko, Peter Olwoch, John Ategeka, Patience Nayebare, Tamara D Clark, Gabrielle Rizzuto, Atis Muehlenbachs, Diane V Havlir, Moses R Kamya, Grant Dorsey, Stephanie L Gaw
BACKGROUND: Malaria in pregnancy has been associated with maternal morbidity, placental malaria, and adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of malaria during pregnancy, measures of placental malaria, and birth outcomes. METHODS: This is a nested observational study of data from a randomized controlled trial of intermittent preventive therapy during pregnancy among 282 participants with assessment of placental malaria and delivery outcomes...
October 5, 2017: Malaria Journal
Andrew B Foster, Viktor Bagutski, Josue I Ayuso-Carrillo, Martin J Humphries, Michael J Ingleson, Michael L Turner
Polytriarylamine copolymers can be prepared by Suzuki-Miyaura cross-coupling reactions of bis N-methyliminodiacetic acid (MIDA) boronate ester substituted arylamines with dibromo arenes. The roles of solvent composition, temperature, reaction time, and co-monomer structure were examined and (co)polymers prepared containing 9, 9-dioctylfluorene (F8), 4-sec-butyl or 4-octylphenyl diphenyl amine (TFB), and N, N'-bis(4-octylphenyl)-N, N'-diphenyl phenylenediamine (PTB) units, using a Pd(OAc)2/2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (SPhos) catalyst system...
September 1, 2017: Journal of Polymer Science. Part A, Polymer Chemistry
Tarik Benmarhnia, Jonathan Huang, Rupa Basu, Jun Wu, Tim A Bruckner
BACKGROUND: Racial/ethnic disparities in preterm birth (PTB) are well documented in the epidemiological literature, but little is known about the relative contribution of different social and environmental determinants of such disparities in birth outcome. Furthermore, increased focus has recently turned toward modifiable aspects of the environment, including physical characteristics, such as neighborhood air pollution, to reduce disparities in birth outcomes. OBJECTIVES: To apply decomposition methods to understand disparities in preterm birth (PTB) prevalence between births of non-Hispanic black individuals and births of non-Hispanic white individuals in California, according to individual demographics, neighborhood socioeconomic environment, and neighborhood air pollution...
October 4, 2017: Environmental Health Perspectives
Aanchal Katoch, Biju George, Amrutha Iyyappan, Debjit Khan, Saumitra Das
p53 and its translational isoform Δ40p53 are involved in many important cellular functions like cell cycle, cell proliferation, differentiation and metabolism. Expression of both the isoforms can be regulated at different steps. In this study, we explored the role of 3'UTR in regulating the expression of these two translational isoforms. We report that the trans acting factor, Polypyrimidine Tract Binding protein (PTB), also interacts specifically with 3'UTR of p53 mRNA and positively regulates expression of p53 isoforms...
September 29, 2017: Nucleic Acids Research
Shaifali Tyagi, Neera Sharma, Jaya Sivaswami Tyagi, Sagarika Haldar
Pleural tuberculosis (pTB) is a grave form of extrapulmonary tuberculosis. Microbiological tests are usually found to be inadequate for pTB diagnosis. The absence of a uniform 'composite reference standard' is challenging; therefore, diagnosis is usually performed using a combination of diversified criteria. Nucleic acid tests vary in diagnostic accuracy and have not yet been integrated into clinical decision making. This review assesses the varied criteria used for pTB classification and the challenges afflicting pleural fluid-based DNA diagnostic tests, namely, PCR and Xpert(®) MTB/RIF...
October 2017: Future Microbiology
Ronghua Hu, Yawen Chen, Yiming Zhang, Zhengmin Qian, Yan Liu, Michael G Vaughn, Shunqing Xu, Tongzhang Zheng, Mingzhu Liu, Bin Zhang
OBJECTIVE: Although vomiting in the first trimester has been reported to be associated with preterm birth (PTB), findings supporting this association remain inconsistent. Our aim was to assess the association between vomiting and PTB, as well as evaluate if the association is modified by pre-pregnancy body mass index (BMI). DESIGN: A retrospective cohort study. SETTING: Wuhan, a central city of China. PARTICIPANTS: A total of 317 463 pregnant women who had a live, singleton newborn from 1 January 2010 to 23 May 2016 were enrolled in our study...
September 27, 2017: BMJ Open
Emilie M Herzog, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Kim P J Wijnands, Janine F Felix, Jun Chen, Andrew Stubbs, Peter J van der Spek, Joyce B van Meurs, Régine P M Steegers-Theunissen
INTRODUCTION: Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing maternal cardiovascular- and metabolic risk factors. We hypothesize that PE is associated with altered epigenetic programming of placental and fetal tissues and that these epigenetic changes might elucidate the increased cardiovascular- and metabolic disease susceptibility in PE offspring...
October 2017: Placenta
Shan Lang, Junping Sun, Xuning Wang, Yongjiu Xiao, Juan Wang, Mingyue Zhang, Ting Ao, Jianxin Wang
Asymptomatic pulmonary tuberculosis (PTB) mimicking lung cancer is rare and has been documented in few studies. Accurately diagnosing this atypical disease remains an enormous challenge for clinicians. The aim of the present study was to characterize asymptomatic patients with PTB who were initially diagnosed with lung cancer according to their chest computer tomography (CT) or whole-body 18F-fludeoxyglucose-positron emission tomography-computer tomography (PET-CT) presentations. The clinical characteristics and radiographic features of patients with PTB were analyzed and compared to those of patients with lung cancer...
September 2017: Experimental and Therapeutic Medicine
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