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https://www.readbyqxmd.com/read/28822628/retrospective-cohort-study-of-cervical-pessary-use-in-women-with-short-cervix-at-risk-of-preterm-delivery
#1
Laura Karis Allen, Jane Schulz, Catherine Flood, Sue Ross, Kentia Naud
OBJECTIVE: A paucity of effective interventions exists for the prevention of preterm birth (PTB). Renewed interest has focused on cervical pessaries, which have the benefits of being inexpensive, nonsurgical, and easily inserted and removed. In this study, we aim to describe our experience with this device in a Canadian tertiary care centre. Primary outcomes were rates of spontaneous or iatrogenic PTB before 37, 34, and 28 weeks gestation in pregnancies complicated by short cervix treated with cervical pessary...
August 16, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28806423/new-synthetic-lipid-antigens-for-rapid-serological-diagnosis-of-tuberculosis
#2
Alison Jones, Mark Pitts, Juma'a R Al Dulayymi, James Gibbons, Andrew Ramsay, Delia Goletti, Christopher D Gwenin, Mark S Baird
BACKGROUND: During pulmonary tuberculosis (PTB) antibodies are generated to trehalose esters of mycolic acids which are cell wall lipids of Mycobacterium tuberculosis (Mtb). Attempts have been made to use these complex natural mixtures in serological tests for PTB diagnosis. AIM: The aim of this work was to determine whether a serological test based on a panel of defined individual trehalose esters of characteristic synthetic mycolic acids has improved diagnostic accuracy in distinguishing patients with culture positive PTB from individuals who were Mtb culture negative...
2017: PloS One
https://www.readbyqxmd.com/read/28803058/survey-of-ferns-and-clinico-pathological-studies-on-the-field-cases-of-enzootic-bovine-haematuria-in-himachal-pradesh-a-north-western-himalayan-state-of-india
#3
Sarvesh K Rai, Rinku Sharma, Alka Kumari, Lars H Rasmussen, Rajendra D Patil, Rasbehari Bhar
Enzootic bovine haematuria (EBH) in cattle occurs in upland areas of the world. In India, the disease is present in isolated pockets in the Himalayas and in the Nilgiri Hills. The variation in the disease incidence has been attributed to different environmental conditions and animal rearing practices followed in the different regions. The aim of the study was to conduct field surveys in parts of EBH endemic regions of Himachal Pradesh, a north-western Himalayan state of India. Out of the total 103 plant samples collected, a total of 95 samples were identified as ferns...
August 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28799040/automated-microfluidic-devices-integrating-solid-phase-extraction-fluorescent-labeling-and-microchip-electrophoresis-for-preterm-birth-biomarker-analysis
#4
Vishal Sahore, Mukul Sonker, Anna V Nielsen, Radim Knob, Suresh Kumar, Adam T Woolley
We have developed multichannel integrated microfluidic devices for automated preconcentration, labeling, purification, and separation of preterm birth (PTB) biomarkers. We fabricated multilayer poly(dimethylsiloxane)-cyclic olefin copolymer (PDMS-COC) devices that perform solid-phase extraction (SPE) and microchip electrophoresis (μCE) for automated PTB biomarker analysis. The PDMS control layer had a peristaltic pump and pneumatic valves for flow control, while the PDMS fluidic layer had five input reservoirs connected to microchannels and a μCE system...
August 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28798896/pregnancy-outcomes-in-hiv-infected-women-experience-from-a-tertiary-care-center-in-india
#5
Vatsla Dadhwal, Aparna Sharma, Kavita Khoiwal, Dipika Deka, Plaboni Sarkar, P Vanamail
BACKGROUND AND OBJECTIVES: There is conflicting data on the effect of HIV infection as well as antiretroviral therapy (ART) on pregnancy outcome. The objectives of this study were to compare pregnancy outcomes in women with and without HIV infection, and to evaluate the effect of HAART on pregnancy in HIV-infected women. METHODS: This is a prospective case record analysis of 212 HIV-infected women delivering between 2002 and 2015, in a tertiary health care center in India...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28798414/comparison-of-neonatal-outcomes-following-progesterone-use-during-ovarian-stimulation-with-frozen-thawed-embryo-transfer
#6
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795395/modulation-of-periodontitis-progression-using-ph-responsive-nanosphere-encapsulating-metronidazole-or-n-phenacylthialzolium-bromide
#7
J-H Lin, F Feng, M-C Yu, C-H Wang, P-C Chang
BACKGROUND AND OBJECTIVE: This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis. MATERIAL AND METHODS: PLGA/chitosan nanospheres were fabricated using oil-in-water emulsion method. Experimental periodontitis was induced on the rat maxillae, and the sites were randomly allocated to four treatment categories, including periodontitis alone (PR), periodontitis with nanospheres alone, nanospheres encapsulating metronidazole (MT) and nanospheres encapsulating PTB (PB)...
August 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28792107/intrafetal-laser-for-embryo-reduction-from-dichorionic-triplets-to-dichorionic-twins
#8
Petya Chaveeva, Gergana Peeva, Savino Gil Pugliese, Atanas Shterev, Kypros H Nicolaides
OBJECTIVE: To report the outcome of dichorionic (DC) triplet pregnancies reduced to DC twins by laser ablation of the pelvic vessels of one of the monochorionic twins. METHODS: Intrafetal laser embryo reduction (ER) from DC triplet to DC twins was carried out in 61 pregnancies at 11(+0) - 14(+3) weeks' gestation. Pregnancy outcome was examined and compared to previous studies in DC triplets managed expectantly or by ER to twins or singleton with fetal intracardiac injection of potassium chloride (KCl)...
August 9, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28791264/prediction-of-pregnancy-complication-occurrence-using-fetal-cardiac-output-assessments-made-by-ultrasonography-at-20-to-24-weeks-of-gestation
#9
Ji Yeon Lee, Young Li Kim, Ji Eun Jeong, Jun Woo Ahn
OBJECTIVE: To evaluate the importance of assessment of fetal cardiac output (CO) for the prediction of complications of pregnancy. METHODS: We evaluated 65 fetuses and all of them had a fetal cardiac scan at 20 to 24 weeks of pregnancy. To measure CO, diameters (d) of the left right ventricle outflow tract were measured just above the valves. Each left CO (LCO) and right CO (RCO) was derived using the following equation: CO = velocity time integral × π × d(2)/4 × heart rate...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28781942/prevalence-and-determinants-of-preterm-birth-in-tehran-iran-a-comparison-between-logistic-regression-and-decision-tree-methods
#10
Payam Amini, Saman Maroufizadeh, Reza Omani Samani, Omid Hamidi, Mahdi Sepidarkish
OBJECTIVES: Preterm birth (PTB) is a leading cause of neonatal death and the second biggest cause of death in children under five years of age. The objective of this study was to determine the prevalence of PTB and its associated factors using logistic regression and decision tree classification methods. METHODS: This cross-sectional study was conducted on 4,415 pregnant women in Tehran, Iran, from July 6-21, 2015. Data were collected by a researcher-developed questionnaire through interviews with mothers and review of their medical records...
June 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28781747/recent-advances-in-the-prevention-of-preterm-birth
#11
REVIEW
Jeff A Keelan, John P Newnham
Preterm birth (PTB) remains a major obstetric healthcare problem and a significant contributor to perinatal morbidity, mortality, and long-term disability. Over the past few decades, the perinatal outcomes of preterm neonates have improved markedly through research and advances in neonatal care, whereas rates of spontaneous PTB have essentially remained static. However, research into causal pathways and new diagnostic and treatment modalities is now bearing fruit and translational initiatives are beginning to impact upon PTB rates...
2017: F1000Research
https://www.readbyqxmd.com/read/28776530/rapid-laboratory-diagnosis-of-pulmonary-tuberculosis
#12
Prasanna Bhirud, Ameeta Joshi, Nilma Hirani, Abhay Chowdhary
BACKGROUND: Tuberculosis (TB) ranks as the second leading cause of death from an infectious disease worldwide. Early diagnosis of Mycobacterium tuberculosis in clinical samples becomes important in the control of TB both for the treatment of patients and for curbing of disease transmission to the others in the community. The study objective was to perform Ziehl-Neelsen (ZN) staining, fluorochrome staining, line probe assay (LPA), and loop-mediated isothermal amplification (LAMP) assay for rapid detection of pulmonary TB (PTB) and to compare the results of LPA and LAMP in terms of sensitivity, specificity, and turnaround time...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28768214/estimation-of-disease-burdens-on-preterm-births-and-low-birth-weights-attributable-to-maternal-fine-particulate-matter-exposure-in-shanghai-china
#13
Anni Liu, Naisi Qian, Huiting Yu, Renjie Chen, Haidong Kan
BACKGROUND: Studies have shown that maternal exposure to particulate matter ≤2.5μm in aerodynamic diameter (PM2.5) was associated with adverse birth outcomes such as preterm birth (PTB) and low birth weight (LBW). However, the burdens of PTB and LBW attributable to PM2.5 were rarely evaluated, especially in developing countries. OBJECTIVES: To estimate the burdens of PTBs and LBWs attributable to outdoor PM2.5 in Shanghai, China. METHODS: We collected annual-average PM2...
July 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28764570/short-interpregnancy-interval-increases-the-risk-of-preterm-premature-rupture-of-membranes-and-early-delivery
#14
Raj Shree, Aaron B Caughey, Suchitra Chandrasekaran
OBJECTIVES: Preterm premature rupture of membranes (PPROM) is a major contributor to overall preterm birth (PTB) rates. A short interpregnancy interval (IPI) is a well-known risk factor for PTB. It is unknown if a short IPI specifically affects the risk of developing PPROM in a subsequent pregnancy. We sought to determine the association between IPI and the risk of PPROM in a subsequent pregnancy. METHODS: A retrospective cohort study using the Missouri birth certificate database of singleton births from 2003-2013 was conducted...
August 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28764146/role-of-anaemia-and-magnesium-levels-at-the-initiation-of-tuberculosis-therapy-with-sputum-conversion-among-pulmonary-tuberculosis-patients
#15
Yuthika Agrawal, Vipin Goyal, Abhishek Singh, Sandhya Lal
INTRODUCTION: Both pulmonary Tuberculosis (TB) and anaemia are prevalent in India. Magnesium levels also influence TB. There is limited and inconsistent literature on the association among anaemia, serum magnesium levels and sputum conversion during tuberculosis treatment. AIM: To study the effect of anaemia and serum magnesium levels on sputum conversion in pulmonary TB patients. MATERIALS AND METHODS: One hundred each of newly diagnosed sputum smear positive Pulmonary Tuberculosis (PTB), sputum smear negative PTB patients initiated on Directly Observed Treatment Short Course chemotherapy (DOTS) and healthy age and sex matched controls were recruited in the study...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763862/-a-screening-system-for-anti-metastatic-small-molecule-compounds-based-on-perinucleolar-compartment-prevalence-in-liver-cancer-cells
#16
F F Liu, G H Lou, Y N Liu, H H Zhu, Z Chen
Objective: To establish a screening system for anti-metastatic small-molecule compounds based on perinucleolar compartment (PNC) prevalence in liver cancer cells and to investigate its validity. Methods: Polypyrimidine tract-binding protein (PTB) monoclonal antibody was used to measure the PNC prevalence in HepG2, HepG2M, and Huh7 cells, and wound healing assay and transwell assay were used to analyze the migration and invasion abilities of hepatoma cells. HepG2M cells were used as the model for the screening of anti-metastatic small-molecule compounds, and after the treatment with the compounds A1, A4, and E696, qPCR was used to measure the expression of metastasis-related miRNAs (miR-141 and miR-200c)...
June 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28755480/g3bp1-interacts-directly-with-the-fmdv-ires-and-negatively-regulates-translation
#17
Alfonso Galan, Gloria Lozano, David Piñeiro, Encarnacion Martinez-Salas
RNA-protein interactions play a pivotal role in the function of picornavirus internal ribosome entry site (IRES) elements. Here we analysed the impact of Ras GTPase SH3 domain binding protein 1 (G3BP1) in the IRES activity of foot-and-mouth disease virus (FMDV). We found that G3BP1 interacts directly with three distinct sequences of the IRES element using RNA electrophoretic mobility-shift assays. Analysis of the interaction with domain 5 indicated that the G3BP1 binding-site is placed at the single-stranded region although it allows large sequence heterogeneity and the hairpin located upstream of this region enhances retarded complex formation...
July 29, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28755152/assisted-reproduction-and-risk-of-preterm-birth-in-singletons-by-infertility-diagnoses-and-treatment-modalities-a-population-based-study
#18
Galit Levi Dunietz, Claudia Holzman, Yujia Zhang, Chenxi Li, David Todem, Sheree L Boulet, Patricia McKane, Dmitry M Kissin, Glenn Copeland, Dana Bernson, Michael P Diamond
PURPOSE: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. METHODS: Population-based assisted reproductive technology surveillance data for 2000-2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities...
July 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28754971/in-vivo-raman-spectral-analysis-of-impaired-cervical-remodeling-in-a-mouse-model-of-delayed-parturition
#19
Christine M O'Brien, Jennifer L Herington, Naoko Brown, Isaac J Pence, Bibhash C Paria, James C Slaughter, Jeff Reese, Anita Mahadevan-Jansen
Monitoring cervical structure and composition during pregnancy has high potential for prediction of preterm birth (PTB), a problem affecting 15 million newborns annually. We use in vivo Raman spectroscopy, a label-free, light-based method that provides a molecular fingerprint to non-invasively investigate normal and impaired cervical remodeling. Prostaglandins stimulate uterine contractions and are clinically used for cervical ripening during pregnancy. Deletion of cyclooxygenase-1 (Cox-1), an enzyme involved in production of these prostaglandins, results in delayed parturition in mice...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748775/reduction-in-extrapulmonary-tuberculosis-in-context-of-antiretroviral-therapy-scale-up-in-rural-south-africa
#20
J C Hoogendoorn, L Ranoto, N Muditambi, J Railton, M Maswanganyi, H E Struthers, J A McIntyre, R P H Peters
Scale-up of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection has reduced the incidence of pulmonary tuberculosis (PTB) in South Africa. Despite the strong association of HIV infection with extrapulmonary tuberculosis (EPTB), the effect of ART on the epidemiology of EPTB remains undocumented. We conducted a retrospective record review of patients initiated on treatment for EPTB in 2009 (ART coverage <5%) and 2013 (ART coverage 41%) at four public hospitals in rural Mopani District, South Africa...
September 2017: Epidemiology and Infection
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