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https://www.readbyqxmd.com/read/28343179/nulliparous-teenagers-and-preterm-birth-in-california
#1
Jonathan A Mayo, Bat Zion Shachar, David K Stevenson, Gary M Shaw
BACKGROUND: Young maternal age is one of the numerous risk factors for delivery before 37 weeks of gestation, yet the mechanisms are unclear. The purpose of the current study was to investigate the association between teenagers and the risk of preterm birth (PTB) in a large and recent cohort study. METHODS: We conducted a population-based retrospective cohort study using 2007-2011 California birth certificate records linked with hospital discharge indices and United States census data for nulliparous 13-20 year olds who gave birth to singletons...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28336737/comparative-effectiveness-of-different-wound-dressings-for-patients-with-partial-thickness-burns-study-protocol-of-a-systematic-review-and-a-bayesian-framework-network-meta-analysis
#2
Qiong Jiang, Zhao-Hong Chen, Shun-Bin Wang, Xiao-Dong Chen
INTRODUCTION: Selecting a suitable wound dressing for patients with partial-thickness burns (PTBs) is important in wound care. However, the comparative effectiveness of different dressings has not been studied. We report the protocol of a network meta-analysis designed to combine direct and indirect evidence of wound dressings in the management of PTB. METHODS AND ANALYSIS: We will search for randomised controlled trials (RCTs) evaluating the wound-healing effect of a wound dressing in the management of PTB...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28336310/regulatory-role-of-ccl5-rs2280789-and-cxcl10-rs56061981-gene-polymorphisms-on-intracellular-ccl5-and-cxcl10-expression-in-pulmonary-tuberculosis
#3
Brijendra Singh, Selvaraj Anbalagan, Paramasivam Selvaraj
Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellular CCL5 and CXCL10 expression in T cells. Whole blood cell cultures were stimulated with culture filtrate antigen (CFA) and infected with live M. tuberculosis were used for intracellular CCL5 and CXCL10 expression using flow cytometry...
March 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28335803/spatial-temporal-analysis-of-pulmonary-tuberculosis-in-the-northeast-of-the-yunnan-province-people-s-republic-of-china
#4
Li Huang, Xin-Xu Li, Eniola Michael Abe, Lin Xu, Yao Ruan, Chun-Li Cao, Shi-Zhu Li
BACKGROUND: The number of pulmonary tuberculosis (PTB) cases in China ranks third in the world. A continuous increase in cases has recently been recorded in Zhaotong prefecture-level city, which is located in the northeastern part of Yunnan province. This study explored the space-time dynamics of PTB cases in Zhaotong to provide useful information that will help guide policymakers to formulate effective regional prevention and control strategies. METHODS: The data on PTB cases were extracted from the nationwide tuberculosis online registration system...
March 24, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28335802/use-of-low-dose-computed-tomography-to-assess-pulmonary-tuberculosis-among-healthcare-workers-in-a-tuberculosis-hospital
#5
Wei He, Bu-Dong Chen, Yan Lv, Zhen Zhou, Jin-Ping Xu, Ping-Xin Lv, Xin-Hua Zhou, Feng-Gang Ning, Cheng-Hai Li, Dong-Po Wang, Jie Zheng
BACKGROUND: According to the World Health Organization, China is one of 22 countries with serious tuberculosis (TB) infections and one of the 27 countries with serious multidrug-resistant TB strains. Despite the decline of tuberculosis in the overall population, healthcare workers (HCWs) are still at a high risk of infection. Compared with high-income countries, the TB prevalence among HCWs is higher in low- and middle-income countries. Low-dose computed tomography (LDCT) is becoming more popular due to its superior sensitivity and lower radiation dose...
March 24, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28333932/impairment-of-wnt-%C3%AE-catenin-signaling-in-blood-cells-of-patients-with-severe-cavitary-pulmonary-tuberculosis
#6
Lin Fan, Hongbo Shen, Huichang Huang, Rui Yang, Lan Yao
Tuberculosis (TB) remains as a leading infectious disease worldwide. Our previous study showed interferon (IFN)-γ and CD3 T cell impairment in patients with severe cavitary pulmonary TB (PTB). However, the cause of the change in immune responses during the progression of TB is still poorly understood. In this study, eight newly diagnosed patients with severe cavitary and mild lesion non-cavity PTB were recruited, and three healthy volunteers were recruited as the control. RNA extracted from blood was tested by whole genome oligo microarrays...
2017: PloS One
https://www.readbyqxmd.com/read/28331211/association-between-the-mif-173g-c-polymorphism-and-serum-mif-levels-with-pulmonary-tuberculosis-a-meta-analysis
#7
Xiang Tong, Zhipeng Yan, Qilong Zhou, Sitong Liu, Jing Han, Yao Ma, Xue Yang, Hong Fan
Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the controls. However, the results of these studies were underpowered. The current study aimed to precisely evaluate the association between the MIF-173G/C polymorphism and serum MIF concentrations with PTB. Therefore, a systematic literature search was preformed to identify studies involving the indicated association...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330094/characterization-of-antibiotic-resistant-and-enzyme-producing-bacterial-strains-isolated-from-the-arabian-sea
#8
Preeti N Tallur, Dayanand B Sajjan, Sikandar I Mulla, Manjunatha P Talwar, A Pragasam, Vinayak M Nayak, Harichandra Z Ninnekar, Shivanand S Bhat
Marine bacteria are known to produce many bioactive molecules and extracellular enzymes of commercial importance. We have investigated the bacterial diversity of the coastal area of Karwar, Karnataka State, India. Among these bacterial isolates, five bacterial strains were selected and identified by their morphological, biochemical characteristics and phylogenetic analysis based on 16S rRNA gene sequences. The identified bacterial isolates, Bacillus toyonensis PNTB1, Lysinibacillus sphaericus PTB, Vibrio vulnificus PMD, Shewanella MPTDBS, and Pseudomonas chlororaphis PNTB were characterized for their tolerance to salt and antibiotics...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327589/non-occupational-physical-activity-during-pregnancy-and-the-risk-of-preterm-birth-a-meta-analysis-of-observational-and-interventional-studies
#9
Ju Wen, Pengcheng Xun, Cheng Chen, Minghui Quan, Ru Wang, Yu Liu, Ka He
A meta-analysis was conducted to evaluate the association between non-occupational physical activity (PA) during pregnancy and the risk of preterm birth (PTB). By searching PubMed and EMBASE from inception to August 20, 2016, 25 observational studies (18 cohorts and 7 case-controls) and 12 interventional studies were identified. Comparing the highest to the lowest category of leisure-time PA during pregnancy, the pooled relative risk (RR) of PTB was 0.83 [95% confidence interval (CI) = 0.74-0.93] for cohort studies and 0...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322992/activation-of-the-intronic-cryptic-5-splice-site-depends-on-its-distance-to-the-upstream-cassette-exon
#10
Wei Liu, Xia Li, Shengjie Liao, Kefeng Dou, Yi Zhang
Splice site selection is a key step that determines the mRNA isoforms generated from a single transcript. The large diversity in splice site sequences emphasizes the plasticity of splice site recognition and selection. In this report, a cell-based reporter system using a SMN1/2 cassette exon was applied to the roles governing the activation of a cryptic 5'SS from the intron 4 of the CT/CGRP gene. We found that the cryptic site was activated when placed within 124nt downstream the cassette exon, and the level of activation was negatively correlated with its distance from the exon...
March 18, 2017: Gene
https://www.readbyqxmd.com/read/28322133/rosiglitazone-regulates-tlr4-and-rescues-ho-1-and-nrf2-expression-in-myometrial-and-decidual-macrophages-in-inflammation-induced-preterm-birth
#11
Leena Kadam, Nardhy Gomez-Lopez, Tara Mial, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
INTRODUCTION: Elevated inflammation accounts for approximately 30% of preterm birth (PTB) cases. We previously reported that targeting the peroxisome proliferator-activated receptor gamma (PPARγ) pathway reduced the incidence of PTB in the mouse model of endotoxin-induced PTB. The PPARγ has proven anti-inflammatory functions and its activation via rosiglitazone significantly downregulated the systemic inflammatory response and reduced PTB and stillbirth rate by 30% and 41%, respectively, in our model...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28320976/a-study-on-the-efficacy-of-the-recombinant-yersinia-adhesin-a-vaccine-against-yersiniosis-in-the-early-phase
#12
Kosuke Tsugo, Shin/Ichi Nakamura, Hiroko Yamanaka, Yumi Une
Yersinia pseudotuberculosis (Y. ptb) is a zoonotic pathogenic bacterial species of the family Enterobacteriaceae and causes yersiniosis, an acute intestinal infection in humans and animals. Y. ptb is often implicated in lethal epidemics in zoo animals and reductions in the breeding population, but a valid prevention method has not been established. Therefore, this study aimed to develop a vaccine for yersiniosis control. The immunogenicity of one of the adhesion factors involved in pathogenic mechanisms of Y...
March 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28320241/implementation-of-a-universal-cervical-length-screening-program-identifying-factors-associated-with-decline-rates
#13
Jeny Ghartey, Neda Ghaffari, Lisa D Levine, Nadav Schwartz, Celeste P Durnwald
PURPOSE: Cervical length (CL) measurement is now accepted as a screening strategy for identifying women at risk for preterm birth (PTB). However, patient acceptability may limit its implementation. Our objective was to identify characteristics associated with women who decline this screening. MATERIALS AND METHODS: This is a secondary analysis of a prospective cohort study of women offered UCL screening from January 2012-June 2012. Women with a singleton gestation 18 0/7-23 6/7 weeks at the time of anatomy scan were included...
March 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28319314/progesterone-to-prevent-preterm-birth-the-studies-are-getting-better-but-there-is-still-room-for-improvement
#14
Carr Men Chung, Maud van Zijl, Jeffrey A Keelan, Ben Willem Mol
Spontaneous preterm birth (PTB) remains one of the pressing problems of modern obstetrics. Allen and Corner first isolated progesterone and proposed the name because of its pro-gestational activity (Allen 1930). Progesterone prolongs pregnancy via a range of actions in the myometrium, cervix and placenta which, when exploited pharmacologically, might delay or even prevent PTB. This article is protected by copyright. All rights reserved.
March 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28317813/association-between-pulmonary-tuberculosis-and-type-2-diabetes-in-sudanese-patients
#15
Mona Ahmed, Ibtihal Omer, Sannaa M A Osman, Eltayib H Ahmed-Abakur
INTRODUCTION: Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues, and the association between DM and TB may be the next challenge for global TB control worldwide, type 2 DM (T2DM) responsible for 90% of DM cases. Persons with diabetes have a significantly increased risk of active TB, which is two to three times higher than in persons without diabetes. The aim of this study was to determine the association between pulmonary tuberculosis (PTB) and T2DM among Sudanese patients and also to determine the association between hemoglobin A1c (HbA1c) percentage in diabetic patients and development of PTB and effect of duration of T2DM in developing PTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317804/a-survey-on-undiagnosed-active-pulmonary-tuberculosis-among-pregnant-mothers-in-mekelle-and-surrounding-districts-in-tigray-ethiopia
#16
Dawit Gebreegziabiher, Kelemework Adane, Markos Abebe
OBJECTIVE/BACKGROUND: To determine the prevalence of undiagnosed active pulmonary tuberculosis (PTB) cases and sensitivity, specificity, and positive and negative predictive values of symptom combinations for undiagnosed TB infection in human immunodeficiency virus (HIV)-positive and HIV-negative pregnant mothers attending antenatal care (ANC) clinics. Mycobacterium TB and HIV are the leading causes of death among women of reproductive age worldwide. Symptom screening is the first step in the World Health Organization (WHO)-recommended TB intensified case finding algorithm for people living with HIV...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28316639/feature-extraction-and-classification-of-ehg-between-pregnancy-and-labour-group-using-hilbert-huang-transform-and-extreme-learning-machine
#17
Lili Chen, Yaru Hao
Preterm birth (PTB) is the leading cause of perinatal mortality and long-term morbidity, which results in significant health and economic problems. The early detection of PTB has great significance for its prevention. The electrohysterogram (EHG) related to uterine contraction is a noninvasive, real-time, and automatic novel technology which can be used to detect, diagnose, or predict PTB. This paper presents a method for feature extraction and classification of EHG between pregnancy and labour group, based on Hilbert-Huang transform (HHT) and extreme learning machine (ELM)...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28306725/maternal-vitamin-d-insufficiency-and-risk-of-adverse-pregnancy-and-birth-outcomes-a-systematic-review-and-meta-analysis-of-longitudinal-studies
#18
A Kofi Amegah, Moses K Klevor, Carol L Wagner
BACKGROUND: Three previous reviews on the association of vitamin D insufficiency in pregnancy with preterm birth (PTB) and stillbirth were limited in scope and deemed inconclusive. With important new evidence accumulating, there is the need to update the previous estimates and assess evidence on other clinically important outcomes such as spontaneous abortion and Apgar score. We conducted a systematic review and meta-analysis to evaluate the quality and strength of the available evidence on the relations between vitamin D nutritional status, and pregnancy and birth outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28303781/delays-in-diagnosis-and-treatment-of-pulmonary-tuberculosis-in-afb-smear-negative-patients-with-pneumonia
#19
Z X Zhang, L-H Sng, Y Yong, L M Lin, T W Cheng, N H Seong, F K Yong
<h2>BACKGROUND:</h2><p>Diagnostic and treatment delays increase the severity and transmission of pulmonary tuberculosis (PTB). This study aimed to evaluate TB diagnostic and treatment delays in acid-fast bacilli (AFB) smear-negative patients.</p><h2>METHODS:</h2><p>This was a retrospective observational study. Patients with positive AFB culture of <i>Mycobacterium tuberculosis</i> complex (MTC) were selected from among hospitalised patients with a diagnosis of pneumonia...
March 16, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28302070/prevalence-and-incidence-of-smear-positive-pulmonary-tuberculosis-in-the-hetosa-district-of-arsi-zone-oromia-regional-state-of-central-ethiopia
#20
ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen, Bernt Lindtjørn
BACKGROUND: The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of tuberculosis in the Hetosa District of Oromia Region, Ethiopia. METHODS: First, a population-based cross-sectional survey was conducted on a total of 33,073 individuals aged ≥ 15 years to determine the prevalence of PTB+ and BCTB cases. Then, in order to determine the incidence, a prospective follow-up was carried out on 32,800 individuals found to be either free from symptoms suggestive of TB (SSTB) during the baseline survey or had symptoms suggestive of TB but yielded negative bacteriological examination results...
March 16, 2017: BMC Infectious Diseases
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