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Mohan Shashikant Kamath, Belavendra Antonisamy, Hepsy Y Selliah, Antonio La Marca, Sesh Kamal Sunkara
It is a matter of interest whether pregnancies with the use of donor sperm are associated with a higher risk of adverse perinatal outcomes compared with partner sperm. Anonymized data were obtained from the Human Fertilization & Embryology Authority. Data from 1991 to 2011 involving a total of 95,787 singleton births (4523 with donor sperm and 91,264 with partner sperm) following fresh IVF/intracytoplasmic sperm injection (ICSI) were analysed to compare perinatal outcomes of preterm birth (PTB), low birthweight (LBW) and high birthweight (HBW)...
April 6, 2018: Reproductive Biomedicine Online
Alladi Mohan, J Harikrishna, D Prabath Kumar, N Dinesh Kumar, Prerna S Sharma, B Siddhartha Kumar, K V S Sarma
Background & objectives: : As sparse published data are available regarding burden of human immunodeficiency virus (HIV) infection in incident tuberculosis (TB) cases at tertiary care teaching hospitals under National TB Programme conditions from India, the present study was designed to assess the proportion of referred registered TB patients who had actually undergone HIV testing and HIV-seropositivity in these. Methods: : This was a study of provider-initiated HIV testing and counselling in patients registered for the treatment under Revised National TB Control Programme (RNTCP) of Government of India at a tertiary care teaching hospital in Tirupati, south India, during 2012-2013...
December 2017: Indian Journal of Medical Research
Gunja Mishra, Satish S Poojary, Sanjay Jain, Pramod Kumar Tiwari
Background & objectives: Sahariya, a primitive tribe of Central India, has shown significantly increased incidence of pulmonary tuberculosis (PTB). Our previous study on Sahariya showed a significant association of -403G>A single nucleotide polymorphism (SNP) of CCL5 with susceptibility to PTB. Hence, this study was aimed to analyze a genotype-phenotype relationship of this disease-associated SNP to develop a potential diagnostic marker for TB in this tribe. Methods: The present study was carried out on 70 plasma samples from Sahariya tribe, wherein the plasma CCL5 level was determined using a commercially available ELISA kit...
December 2017: Indian Journal of Medical Research
G R Kathamuthu, K Moideen, D Baskaran, G Sekar, S Rathinam, V J Bharathi, G R Ganeshan, S Babu
BACKGROUND: Angiogenic factors are important in granuloma formation and serve as biomarkers in pulmonary tuberculosis (PTB). The relationship between these markers and tuberculous lymphadenitis (TBL) is not known. OBJECTIVE AND DESIGN: To examine the association of vascular endothelial growth factor (VEGF) and angiopoietin (Ang) family molecules in TBL, we measured systemic levels of VEGF-A, C, D, R1 (VEGF-receptor 1), R2, R3, Ang-1, Ang-2 and TIE2 (tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2) levels in TBL, latent tuberculous infection (LTBI) and lymph node culture supernatants (VEGF-A, C and Ang-2) of the same TBL patients...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
Shumei He, Shenglai Yang, Qin Zhao, Liang Wang, Hang Liu, Yemeng Sheng, Dongya Yuan, Tianbo Jin
Background: Pulmonary tuberculosis (PTB) is an infectious disease with a high incidence worldwide. Genes encoding cytokines IL4 , IL6 , and IL10 are highly polymorphic and can influence the susceptibility to PTB. Results: We found correlations between one SNP in IL6 (rs2069837 p = 6.63E-11), seven SNPs in IL10 (rs1554286 p = 6.87E-20, rs1518111 p = 6.11E-11, rs3021094 p = 6.75E-29, rs3790622 p = 2.40E-06, rs3024490 p = 6.73E-11, rs1800872 p = 6.18E-11, rs1800871 p = 6...
March 27, 2018: Oncotarget
Marta Silveira da Mota Krüger, Renata Picanço Casarin, Gabriela Dos Santos Pinto, Fernanda Geraldo Pappen, Maria Beatriz Junqueira Camargo, Fernanda Oliveira Bello Correa, Ana Regina Romano
OBJECTIVES: The association between maternal periodontal disease and adverse perinatal outcomes although extensively studied remains unclear. The aim of this study was to evaluate, by a case-control study, conducted in three hospitals the association between preterm birth and/or low birth weight (PTB/LBW) and clinical parameters of maternal periodontal disease. MATERIAL AND METHODS: Postpartum women who gave birth to a newborn PTB/LBW (case group), and postpartum women who had babies at full term with normal weight (control group) were included, in 1:2 ratio...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
Antonella Testa, Francesca Ballarini, Ulrich Giesen, Octávia Monteiro Gil, Mario P Carante, John Tello, Frank Langner, Hans Rabus, Valentina Palma, Massimo Pinto, Clarice Patrono
There is a continued need for further clarification of various aspects of radiation-induced chromosomal aberration, including its correlation with radiation track structure. As part of the EMRP joint research project, Biologically Weighted Quantities in Radiotherapy (BioQuaRT), we performed experimental and theoretical analyses on chromosomal aberrations in Chinese hamster ovary cells (CHO-K1) exposed to α particles with final energies of 5.5 and 17.8 MeV (absorbed doses: ∼2.3 Gy and ∼1.9 Gy, respectively), which were generated by the microbeam at the Physikalisch-Technische Bundesanstalt (PTB) in Braunschweig, Germany...
April 6, 2018: Radiation Research
Virginie Van Leeuw, Charlotte Leroy, Yvon Englert, Wei-Hong Zhang
OBJECTIVES: To investigate the effect of maternal origin on the association between maternal height and the risk of preterm birth (PTB). DESIGN: Retrospective observational cohort study. SETTING: Two of the three Belgian regions, including Brussels-Capital and Walloon regions. PARTICIPANTS: A total of 245 204 women spontaneously delivered live singletons between 2009 and 2013. Maternal nationality at the time of birth included Belgium, Congo, French, Italy, Morocco, Poland, Romania and Turkey...
April 5, 2018: BMJ Open
Ning Zhou, Ning Wang, Xiang Qin, Qian Liu, Juhua Wang, Hui Dong, Jie Zhou, Fugui Fang
Follicle-stimulating hormone (FSH) regulates oogenesis and spermatogenesis by binding to its receptor (FSHR) on target cells in the ovary and testis, respectively. The signaling cascades activated after ligand binding are extremely complex and have been shown to include protein kinase A and phosphatidylinositol 3-kinase/protein kinase. The adapter protein APPL1 (adapter protein with PH domain, PTB domain, and leucine zipper), which is an assortment of other signaling proteins, was previously identified to interact with the FSH receptor (FSHR) and the protein kinase B (AKT) pathway...
December 2017: Polish Journal of Veterinary Sciences
Mao Ye, Lv-Fei Bian
Background: We performed a meta-analysis to investigate the association of serum leptin levels with the pathogenesis of pulmonary tuberculosis (PTB). Methods: The retrieval of related articles was achieved through searching the electronic databases according to strict inclusion criteria. The STATA version 12.0 statistical software was employed to calculate the standardized mean difference (SMD) and 95% confidence interval (CI) during the statistical analysis. Results: Twelve case-control studies were enrolled in this meta-analysis...
February 2018: Journal of Thoracic Disease
Leen Al-Hafez, Suneet P Chauhan
Across the globe, approximately 14.9 million of the annual 135 million births were preterm birth (PTB). While the rate of delivery before 37 weeks varies between countries, the widely acknowledged associated morbidity and mortality, is undeniable and daunting (Blencowe H et al. Lancet. 2012;379:2162-72). One viable strategy to alleviate the adverse outcomes linked with PTB is to use evidence-based recommendations that are promulgated in national guidelines, for the management of preterm labor (PTL). This article is protected by copyright...
March 31, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Sarahn Wheeler, Pamela Maxson, Tracy Truong, Geeta Swamy
Objectives Studies examining risk factors for preterm birth (PTB) such as psychosocial stress are often focused on women with a history of PTB; however, most preterm babies are born to women with no history of preterm birth. Our objective was to determine if the relationship between psychosocial stress and PTB is altered by parity. Non-Hispanic black (NHB) women have increased psychosocial stress and PTB; therefore, we further aimed to determine if race alters the relationship between psychosocial stress, parity, and PTB...
March 29, 2018: Maternal and Child Health Journal
Li Ke, Weiyan Lin, Yangqi Liu, Weilin Ou, Zhifeng Lin
Women who have previously had an induced abortion (IA) before their first birth have been associated with preterm birth (PTB). However, previous studies on the PTB are inconsistent. Therefore, the aim of this study was to clarify the association between IA and PTB and low birth weight (LBW) for first-time mothers. A total of 3,684 Southern Chinese women who gave birth for the first time to a live singleton infants were recruited between January 2015 and December 2015 in the province of Guangdong, China. Univariable and multivariable analyses were conducted to determine whether IA was associated with PTB and LBW...
March 29, 2018: Scientific Reports
Miti A Shah, Ira Shah
SETTING: B.J.Wadia Hospital,Mumbai OBJECTIVE:: The prevalence and type of DR-TB was evaluated pre and post-2013 and outcome was studied. DESIGN: Descriptive retrospective study. Children were defined as having DR-TB on the basis of GeneXpert or LPA and/or drug susceptibility testing(DST) of MTB grown on culture or from contact's DST. RESULTS & CONCLUSION: The prevalence of DR-TB was 110 out of 1145 cases (9.6%) which showed an increase, compared to 5...
March 24, 2018: Pediatric Infectious Disease Journal
Rupak Shivakoti, Nikhil Gupte, Nathella Pavan Kumar, Vandana Kulkarni, Usha Balasubramanian, Ramesh Bhosale, Pradeep Sambrey, Aarti Kinikar, Renu Bharadwaj, Sandesh Patil, Sadaf Inamdar, Nishi Suryavanshi, Subash Babu, Robert C Bollinger, Amita Gupta
Background: Preterm birth (PTB) rates are high in HIV-infected populations, even when on treatment. Still, only a subset of all births in HIV-infected pregnant women result in PTB, suggesting risk factors other than HIV infection itself are also important. Inflammation is a known risk factor in uninfected populations but their role in HIV-infected population have not been studied; in addition, the immune pathways involved are not clear and non-invasive immune markers with predictive value are lacking...
March 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Yong-Jia Ji, Pei-Pei Liang, Jia-Yin Shen, Jian-Jun Sun, Jun-Yang Yang, Jun Chen, Tang-Kai Qi, Zhen-Yan Wang, Wei Song, Yang Tang, Li Liu, Ren-Fang Zhang, Yin-Zhong Shen, Hong-Zhou Lu
BACKGROUND: Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries. Knowledge of the survival of HIV-infected patients with pulmonary tuberculosis (PTB) would provide important insights for the clinical management of this population, which remains to be well described in current China. METHODS: HIV-infected patients with PTB admitted to Shanghai Public Health Clinical Center from January 2011 to December 2015 were retrospectively enrolled...
March 24, 2018: Infectious Diseases of Poverty
Atiwat Soontornpun, Tararak Choovanichvong, Theera Tongsong
OBJECTIVE: The objective of this study was to compare adverse pregnancy outcomes between pregnancies that involve epilepsy and those that do not and are identified as normal for the purposes of this paper. METHODS: A retrospective cohort study was carried out by accessing the maternal-fetal medicine (MFM) database to identify and review records of singleton pregnancies with epilepsy but with no other underlying disease (study group). A parallel group of low-risk pregnancies was randomly allocated as the control group...
March 24, 2018: Epilepsy & Behavior: E&B
He Sun, Yilin Xiao, Yongjun Gao, Guijie Zhang, John F Casey, Yanan Shen
Lithium (Li) isotope analyses of sedimentary rocks from the Meishan section in South China reveal extremely light seawater Li isotopic signatures at the Permian-Triassic boundary (PTB), which coincide with the most severe mass extinction in the history of animal life. Using a dynamic seawater lithium box model, we show that the light seawater Li isotopic signatures can be best explained by a significant influx of riverine [Li] with light δ7 Li to the ocean realm. The seawater Li isotope excursion started ≥300 Ky before and persisted up to the main extinction event, which is consistent with the eruption time of the Siberian Traps...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
Hosien Shahdadi, Morteza Salarzaee, Abbas Balouchi
BACKGROUND: The quality of life is an important indicator of quality of care in chronic diseases such as diabetes and TB. The present research is conducted with an aim to assess the Quality of Life of Diabetic Patients with Smear Positive PTB. METHODS: This cross-sectional study was conducted on 62 diabetic patients with smear positive PTB from January to May 2016 in a diabetes clinic in Zahedan city (southeast of Iran). A simple random sampling method was used in this study...
April 2018: Indian Journal of Tuberculosis
Rohit Sarin, Vikram Vohra, U K Khalid, Prem Prakash Sharma, Vineet Chadha, M A Sharada
BACKGROUND: A survey was carried out to estimate the point prevalence of bacteriologically positive pulmonary tuberculosis (PTB) among persons ≥15 years of age residing in Jhuggi-Jhopri (JJ) colonies - urban slums in Delhi, India implementing Directly Observed Treatment strategy since 1998. METHODS: Among 12 JJ colonies selected by simple random sampling, persons having persistent cough for ≥2 weeks at the time of the survey or cough of any duration along with history of contact/currently on ant-TB treatment/known HIV positive were subjected to sputum examination - 2 specimens, by smear microscopy for Acid Fast Bacilli and culture for Mycobacterium tuberculosis...
April 2018: Indian Journal of Tuberculosis
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