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https://www.readbyqxmd.com/read/29223898/exposure-to-low-concentrations-of-air-pollutants-and-adverse-birth-outcomes-in-brisbane-australia-2003-2013
#1
Gongbo Chen, Yuming Guo, Michael J Abramson, Gail Williams, Shanshan Li
BACKGROUND: It's unclear whether exposures to low-level air pollution have adverse effects on birth outcomes, and which trimester-specific pregnant exposure is sensitive. OBJECTIVES: To investigate the effects of maternal exposure during each trimester and the whole pregnancy to particles with aerodynamic diameter<2.5μm (PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) on preterm birth (PTB) and low birth weight (LBW). METHODS: Daily data on birth records, air quality, and weather conditions were collected in Brisbane, Australia during 2003-2013...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29219243/genetic-polymorphism-of-human-leucocyte-antigen-and-susceptibility-to-multidrug-resistant-and-rifampicin-resistant-tuberculosis-in-han-chinese-from-hubei-province
#2
X Zhou, Q Zhou, Z-F Yang, W-X Li
We determined the high-resolution allele and haplotype frequencies at the human leucocyte antigen (HLA)A, B and DRB1 loci in the Han population of Hubei province, the TB endemic area of Central China, with pulmonary tuberculosis (PTB), and established the relationship between HLA-A, B and DRB1 alleles as well as haplotypes and susceptibility to multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB). Blood samples were drawn from 174 patients with MDR/RR-TB and 838 patients with drug-susceptible PTB in ethnic Han population from Hubei province (central China)...
December 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29218490/fathers-count-the-impact-of-paternal-risk-factors-on-birth-outcomes
#3
Ying Meng, Susan W Groth
Objective To determine the contribution of paternal factors to the risk of adverse birth outcomes. Methods This is a retrospective cross-sectional analysis using birth certificate data from 2004 to 2015 retrieved from the Finger Lakes Regional Perinatal Data System. Primiparous women with singleton pregnancies were analyzed in the study. Two multivariate logistic regression models were conducted to assess potential paternal risk factors including age, race/ethnicity, and education on four birth outcomes, including preterm birth (PTB), low birthweight (LBW), high birthweight (HBW), and small for gestational age (SGA)...
December 7, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29217616/interactome-mapping-uncovers-a-general-role-for-numb-in-protein-kinase-regulation
#4
Ran Wei, Tomonori Kaneko, Xuguang Liu, Huadong Liu, Lei Li, Courtney Voss, Eric Liu, Ningning He, Shawn S C Li
Cellular functions are frequently regulated by protein-protein interactions involving the binding of a modular domain in one protein to a specific peptide sequence in another.  This mechanism may be explored to identify binding partners for proteins harboring a peptide-recognition domain. Here we report a proteomic strategy combining peptide and protein microarray screening with biochemical and cellular assays to identify modular domain-mediated protein-protein interactions in a systematic manner. We applied this strategy to Numb, a multi-functional protein containing a phosphotyrosine-binding (PTB) domain...
December 7, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29215188/pcr-test-in-induced-sputum-of-patients-with-pulmonary-tuberculosis
#5
Verônica da Silva Paiva, Fernanda Luiza Staub, Dirceu Felipe Valentini, Regina Bones Barcellos, Karen Barros Schmid, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Paulo de Tarso Roth Dalcin, Denise Rossato Silva
INTRODUCTION: Induced sputum (IS) is an alternative method of obtaining sputum, but IS smears are frequently negative. Culture is more time-consuming in its results, and less useful to guide the diagnosis. Polymerase chain reaction (PCR) is the most common methodology for rapid diagnosis of TB, and few studies evaluated its role in IS samples. OBJECTIVES: The objective of this study is to determine the diagnostic yield of PCR for TB compared with culture in IS samples...
December 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29214043/folic-acid-level-and-preterm-birth-among-sudanese-women
#6
Manal E Sharif, Ahmed Mohamedain, AbdelBagi A Ahmed, Abubakr M Nasr, Ishag Adam
Background: Preterm birth (PTB) is the major health problem world-wide; there are few published studies on PTB and folic acid. Methods: The study was conducted to assess the serum level of folic acid in PTB. A case-control study was conducted at Saad Abualila maternity hospital (Khartoum, Sudan) during the period of March through December 2015. Women who delivered live singleton babies were dived in two groups; the cases were women who had PTB "delivery before completed 37weeks but after 24 weeks of pregnancy" and the controls were women who delivered at term (37-42 weeks)...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29212525/establishing-and-characterizing-patient-derived-xenografts-using-pre-chemotherapy-percutaneous-biopsy-and-post-chemotherapy-surgical-samples-from-a-prospective-neoadjuvant-breast-cancer-study
#7
Jia Yu, Bo Qin, Ann M Moyer, Jason P Sinnwell, Kevin J Thompson, John A Copland, Laura A Marlow, James L Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu, Jason Hubbard, Donald W Northfelt, Richard J Gray, Katie Hunt, Amy L Conners, Vera J Suman, Krishna R Kalari, James N Ingle, Zhenkun Lou, Daniel W Visscher, Richard Weinshilboum, Judy C Boughey, Matthew P Goetz, Liewei Wang
BACKGROUND: Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting. However, in the setting of operable breast cancer, PDX models both sensitive and resistant to chemotherapy are needed for drug development and prospective data are lacking regarding the clinical and molecular characteristics associated with PDX take rate in this setting...
December 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29199752/structure-and-dynamics-of-solvent-molecules-inside-the-polytheonamide-b-channel-in-different-environments-a-molecular-dynamics-study
#8
Mahroof Kalathingal, Takashi Sumikama, Toshifumi Mori, Shigetoshi Oiki, Shinji Saito
The β6.3-helical channel of the marine cytotoxic peptide, polytheonamide B (pTB), is examined in water, the POPC bilayer, and a 1 : 1 chloroform/methanol mixture using all-atom molecular dynamics simulations. The structures and fluctuations of the β6.3-helix of pTB are investigated in the three environments. The average structure of pTB calculated in the mixed solvent is in good agreement with the NMR-resolved structure in the mixed solvent, indicating the validity of the parameters used for the non-standard groups in pTB...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29194515/state-of-the-art-of-instrumentation-in-experimental-nanodosimetry
#9
A Bantsar, P Colautti, V Conte, G Hilgers, M Pietrzak, S Pszona, H Rabus, A Selva
Nanodosimetry is a branch of dosimetry for investigation and modeling of the interaction pattern of ionizing radiation in nanometre site-sizes (at unit density), which dates back to the 1970's (Pszona S. A track ion counter. Proceedings of Fifth Symposium on Microdosimetry EUR 5452 d-e-f, Published by the Commission of the European Communities, Luxemburg, pp. 1107-1122 (1976)). To date, the different experimental approaches have lead to developing of three fully functional nanodosimeters: the Jet Counter operated at NCBJ, the Ion Counter operated at PTB and Startrack Counter operated at INFN-LNL...
November 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29193660/preterm-birth-with-placental-evidence-of-malperfusion-is-associated-with-cardiovascular-risk-factors-after-pregnancy-a-prospective-cohort-study
#10
Janet M Catov, Matthew F Muldoon, Steven E Reis, Roberta B Ness, Lananh N Nguyen, Jose-Miguel Yamal, Hyunsoo Hwang, W Tony Parks
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. DESIGN: Pregnancy cohort study. SETTING: Pittsburgh Pennsylvania, US. POPULATION: Women with PTB (n=115) and term births (n=210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers were compared in women with prior PTB vs...
November 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29190738/cervical-hsv-2-infection-causes-cervical-remodeling-and-increases-risk-for-ascending-infection-and-preterm-birth
#11
Devin McGee, Arianna Smith, Sharra Poncil, Amanda Patterson, Alison I Bernstein, Karen Racicot
Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. HSV2 infection resulted in histological changes in the cervix mimicking cervical ripening, including significant collagen remodeling and increased hyaluronic acid synthesis...
2017: PloS One
https://www.readbyqxmd.com/read/29188370/predictors-of-cerclage-failure-in-patients-with-singleton-pregnancy-undergoing-prophylactic-cervical-cerclage
#12
K Taghavi, M L Gasparri, D Bolla, D Surbek
PURPOSE: The role of cervical cerclage to prevent preterm birth (PTB) remains controversial. The aim of this study was to identify prognostic factors for cerclage failure among singleton pregnant women following prophylactic cerclage (PC). METHODS: A retrospective analysis of PC was performed in a single center. The main outcome measure was cerclage failure, defined by spontaneous early PTB prior to 32 weeks' gestation. Age, BMI, history of instrumentation of the uterus, history of second trimester miscarriage, previous conization, positive vaginal swab prior cerclage, gestational age at time of cerclage, CRP 1 week after cerclage and post-cerclage US changes of cervical length were tested as predictive factors...
November 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29184327/indicators-to-ensure-treatment-initiation-of-all-diagnosed-sputum-positive-pulmonary-tuberculosis-patients-under-tuberculosis-control-programme-in-india
#13
Lavanya Jayabal, Asha Frederick, Sanjay Mehendale, Velayutham Banurekha
Background: Pretreatment loss to follow-up (PTLFU) is used as performance indicator of Revised National Tuberculosis Control Programme (RNTCP) of India. Objective: To document the PTLFU, identify additional indicators and examine documentation of all the diagnosed sputum positive pulmonary tuberculosis (PTB) patients under RNTCP. Methodology: Tuberculosis (TB) laboratory, referral for treatment registers, and referral forms were perused for information on sputum positive PTB patients diagnosed from January to June 2014, in 3 TB Units in Chennai...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29180322/-peripheral-blood-t-cell-tnf-%C3%AE-and-ifn-%C3%AE-production-stimulated-by-low-molecular-peptide-of-mycobacterium-tuberculosis-heat-resistant-antigen-for-differential-diagnosis-between-pulmonary-tuberculosis-and-latent-tuberculosis-infection
#14
Jie Tang, Ce Chen, Cheng Zha, Jian-Rong Chang, Qiang Fang, Zhao-Hua Wang, Bai-Qing Li
OBJECTIVE: To investigate the effects of low molecular peptide of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg-10k) on the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood T cells and test the feasibility of differential diagnosis between pulmonary tuberculosis (PTB) and latent tuberculosis infection (LTBI) by assessing the number of Mtb-HAg-10k-stimulated IFN-γ-producing T cells. METHODS: Peripheral blood mononuclear cells (PBMCs) were separated from the peripheral blood of 10 healthy adults, 6 individuals with LTBI and 13 patients with PTB...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29174520/liver-dysfunction-during-pregnancy-and-its-association-of-with-preterm-birth-in-china-a-prospective-cohort-study
#15
Xun Zhuang, Ai-Min Cui, Qin Wang, Xiao-Yan Cheng, Yi Shen, Wei-Hua Cai, Hai-Bo Li, Sheng Zhang, Gang Qin
BACKGROUND: Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS: A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between January 1, 2012, and June 30, 2016. Liver function tests (LFTs) were monitored through pregnancy. The primary outcomes were PTB and very PTB (delivery prior 37 and 32weeks' gestation respectively)...
November 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29174108/association-of-prior-hpv-vaccination-with-reduced-preterm-birth-a-population-based-study
#16
Beverley Lawton, Anna S Howe, Nikki Turner, Sara Filoche, Tania Slatter, Celia Devenish, Noelyn Anne Hung
BACKGROUND: Emerging evidence suggests that HPV infection is associated with negative pregnancy outcomes such as preterm birth (PTB), and pre-eclampsia. We aimed to determine if prior HPV vaccination reduced adverse pregnancy outcomes. METHODS: A New Zealand population-based retrospective study linking first pregnancy outcome data (2008-2014 n = 35,646) with prior quadrivalent HPV vaccination status. Primary outcomes were likelihood (odds ratios, ORs) of PTB, pre-eclampsia, and stillbirth...
November 23, 2017: Vaccine
https://www.readbyqxmd.com/read/29171450/treatment-outcome-of-tuberculosis-patients-under-directly-observed-treatment-short-course-and-its-determinants-in-shangla-khyber-pakhtunkhwa-pakistan-a-retrospective-study
#17
Tauseef Ahmad, Muhammad Khan, Muhammad Mumtaz Khan, Eyasu Ejeta, Manoochehr Karami, Chinenyenwa Ohia
BACKGROUND: Tuberculosis (TB) is one of the leading causes of morbidity and mortality in Pakistan. Assessment of TB treatment outcomes, monitoring and evaluation of its risk factors in Directly Observed Treatment Short Course (DOTS) are among the major indicators of the performance of a national TB control program. Even though Pakistan ranks 5th among the 22 high-TB burden countries, there are no available data in this regard. METHODS: Institution-based retrospective study was conducted to determine the treatment outcome of TB patients and investigate associated risk factors at District Head Quarter Hospital Shangla, Khyber-Pakhtunkhwa, Pakistan...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29168465/investigation-of-the-risk-factors-for-pulmonary-tuberculosis-a-case-control-study-among-saharia-tribe-in-gwalior-district-madhya-pradesh-india
#18
Jyothi Bhat, V G Rao, R K Sharma, M Muniyandi, Rajiv Yadav, M K Bhondley
BACKGROUND & OBJECTIVES: Prevalence of pulmonary tuberculosis (PTB) is known to be high in the indigenous tribal community Saharia in Madhya Pradesh, India. The risk factors for PTB are not well known among them. This study was done to determine various risk factors associated with PTB in the indigenous community Saharia. METHODS: A prevalence survey was conducted among Saharias of Gwalior district of Madhya Pradesh. The population surveyed was 12,123 which was the source of cases and controls for the present study...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29167041/efficacy-of-an-internet-based-cognitive-behavioral-stress-management-training-in-women-with-idiopathic-preterm-labor-a-randomized-controlled-intervention-study
#19
Corinne Urech, Sandra Scherer, Martina Emmenegger, Jens Gaab, Sibil Tschudin, Irène Hoesli, Thomas Berger, Judith Alder
OBJECTIVE: This randomized controlled trial aimed at evaluating the efficacy of an internet-based cognitive behavioral stress management program (IB-CBSM) for pregnant women with preterm labor (PTL) on birth outcome and stress-related psychological and biological parameters. METHODS: 93 pregnant women with PTL (gestational age 18-32) were assigned to either the IB-CBSM (n=50) or a control group (CG) based on distraction (n=43). Participants in both groups worked through six weekly modules...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29165793/risk-of-preterm-birth-in-women-with-cervical-intraepithelial-neoplasia-grade-one-a-population-based-cohort-study
#20
Annu Heinonen, Mika Gissler, Jorma Paavonen, Anna-Maija Tapper, Maija Jakobsson
INTRODUCTION: In this population based register study our objective was to explore the association of cervical intraepithelial neoplasia, grade 1 (CIN1) and loop electrosurcigal excision procedure (LEEP) with preterm birth (PTB). MATERIAL AND METHODS: Our population consisted of 4 759 women diagnosed for CIN1 during 1997-2009 and their 3 021 subsequent deliveries analyzed by LEEP and parity. Hospital Discharge Register was used to identify women diagnosed for CIN1 and this data were linked with the Medical Birth Register data...
November 22, 2017: Acta Obstetricia et Gynecologica Scandinavica
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