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https://www.readbyqxmd.com/read/28570611/lipid-profile-of-different-infant-formulas-for-infants
#1
Marcio Antonio Mendonça, Wilma Maria Coelho Araújo, Luiz Antonio Borgo, Ernandes de Rodrigues Alencar
Situations including premature infants, or those in which there is a rejection to breastfeeding, require the use infant formulas for total or partial replacement of human milk. The objective of this study was to determine the lipid content and to identify the lipid profile of infant formulas. Samples were collected from ten different infant formulas, used as a substitute for breast milk at the Maternal and Child Hospital of Brasilia. The human milk sample consisted of a pool of samples from 10 mature milk donors at the milk bank of the University Hospital of Brasilia...
2017: PloS One
https://www.readbyqxmd.com/read/28501559/fast-accurate-and-easy-to-teach-qt-interval-assessment-the-triplicate-concatenation-method
#2
Valentin Saqué, Martino Vaglio, Christian Funck-Brentano, Maya Kilani, Olivier Bourron, Agnès Hartemann, Fabio Badilini, Joe-Elie Salem
BACKGROUND: The gold standard method for assessing the QTcF (QT corrected for heart rate by Fridericia's cube root formula) interval is the "QTcF semiautomated triplicate averaging method" (TAM), which consists of measuring three QTcF values semiautomatically, for each 10-second sequence of a triplicate electrocardiogram set, and averaging them to get a global and unique QTcF value. Thus, TAM is time consuming. We have developed a new method, namely the "QTcF semiautomated triplicate concatenation method" (TCM), which consists of concatenating the three 10-second sequences of the triplicate electrocardiogram set as if they were a single 30-second electrocardiogram, and measuring QTcF only once for the triplicate electrocardiogram set...
May 11, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28349167/evaluation-of-the-effect-of-the-egfr-antibody-drug-conjugate-abt-414-on-qt-interval-prolongation-in-patients-with-advanced-solid-tumors-likely-to-over-express-egfr
#3
MULTICENTER STUDY
Wijith P Munasinghe, Rajendar K Mittapalli, Hong Li, David M Hoffman, Kyle D Holen, Rajeev M Menon, Hao Xiong
PURPOSE: ABT-414 is an antibody-drug conjugate (ADC) being developed for the treatment of tumors harboring amplification of the epidermal growth factor receptor (EGFR). This study evaluated the potential of ABT-414 to prolong the QT interval as part of the initial phase 1 study (NCT01741727). METHODS: Data from patients who received ABT-414 monotherapy at a dose of 1-4 mg/kg once every 3 weeks or 1 or 1.5 mg/kg weekly for 2 out of every 3 weeks (alternate schedule) by intravenous infusion were included in the analysis of triplicate 12-lead ECGs obtained before dosing and through 168 h after dosing...
May 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28140633/effects-of-various-diets-on-the-calcium-and-phosphorus-composition-of-mealworms-tenebrio-molitor-larvae-and-superworms-zophobas-morio-larvae
#4
La'Toya V Latney, Barbara D Toddes, Nicole R Wyre, Dorothy C Brown, Kathryn E Michel, Johanna A Briscoe
OBJECTIVE To evaluate whether the nutritive quality of Tenebrio molitor larvae and Zophobas morio larvae, which are commonly cultured as live food sources, is influenced by 4 commercially available diets used as nutritional substrates; identify which diet best improved calcium content of larvae; and identify the feeding time interval that assured the highest calcium intake by larvae. ANIMALS 2,000 Zophobas morio larvae (ie, superworms) and 7,500 Tenebrio molitor larvae (ie, mealworms). PROCEDURES Larvae were placed in control and diet treatment groups for 2-, 7-, and 10-day intervals...
February 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28040269/comparison-of-the-peak-resolution-and-the-stationary-phase-retention-between-the-satellite-and-the-planetary-motions-using-the-coil-satellite-centrifuge-with-counter-current-chromatographic-separation-of-4-methylumbelliferyl-sugar-derivatives
#5
COMPARATIVE STUDY
Kazufusa Shinomiya, Kazumasa Zaima, Yukina Harada, Miho Yasue, Naoki Harikai, Koji Tokura, Yoichiro Ito
Coil satellite centrifuge (CSC) produces the complex satellite motion consisting of the triplicate rotation of the coiled column around three axes including the sun axis (the angular velocity, ω1), the planet axis (ω2) and the satellite axis (the central axis of the column) (ω3) according to the following formula: ω1=ω2+ω3. Improved peak resolution in the separation of 4-methylumbelliferyl sugar derivatives was achieved using the conventional multilayer coiled columns with ethyl acetate/1-butanol/water (3: 2: 5, v/v) for the lower mobile phase at the combination of the rotation speeds (ω1, ω2, ω3)=(300, 150, 150rpm), and (1:4:5, v/v) for the upper mobile phase at (300:100:200rpm)...
January 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27989224/dairy-farm-wastewater-treatment-using-horizontal-subsurface-flow-wetlands-with-typha-domingensis-and-different-substrates
#6
María Celeste Schierano, María Alejandra Maine, María Cecilia Panigatti
The aim of this work was to evaluate the influence of different substrates in the performance of a horizontal flow constructed wetland employed in dairy farm wastewater treatment. Typha domingensis was chosen for this study due to its high productivity and efficiency in nutrient removal. Fifteen microcosm-scale reactors simulating horizontal flow constructed wetlands were disposed in a greenhouse in triplicate. Five substrates (river gravel, gravel, LECA, river gravel + zeolite and gravel + zeolite) were evaluated...
January 2017: Environmental Technology
https://www.readbyqxmd.com/read/27913774/gravity-flow-in-proposed-enteral-tube-small-bore-connectors
#7
Ryan T Hurt, Lisa M Epp, Adele K Pattinson, Wanda M Duellman, Stephen M Corner, Manpreet S Mundi
BACKGROUND: Enteral nutrition (EN) misconnections have been identified as a serious and potential deadly problem. An international effort led by EN industry leaders has developed a small-bore enteral connector (ENFit) that in theory will reduce the frequency of misconnections. Despite the potential benefit of preventing misconnections, the full impact of adoption of the ENFit connector is unknown. To assess the impact of transitioning to ENFit on our home EN (HEN) patients, the current study evaluated gravity feeding comparing 2 proposed small-bore connectors to the legacy (current connector) using various commercial formulas...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27536712/data-on-nitric-oxide-production-by-human-bone-marrow-derived-mesenchymal-stromal-cells
#8
Mehdi Najar, Mohammad Fayyad-Kazan, Hussein Fayyad-Kazan, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Due to its anti-inflammatory and immunosuppressive potential, Nitric oxide (NO), a gaseous radical, is of special importance during graft-versus-host diseases (GVHD) and feoto-maternal tolerance. NO is a major mediator of murine mesenchymal stromal cells (MSCs)-immunosuppressive capacity. In this data article, we characterized NO production by human bone marrow-derived MSCs (hBMSCs). MSCs, isolated from healthy donors (n=5), were defined according to the International Society for cellular Therapy (ISCT) guidelines...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27103253/consistency-of-cardiac-function-index-and-global-ejection-fraction-with-global-end-diastolic-volume-in-patients-with-femoral-central-venous-access-for-transpulmonary-thermodilution-a-prospective-observational-study
#9
Analena Beitz, Helena Berbara, Sebastian Mair, Benedikt Henschel, Tobias Lahmer, Sebastian Rasch, Roland Schmid, Wolfgang Huber
Global ejection fraction (GEF) and cardiac function index (CFI) are transpulmonary thermodilution (TPTD)-derived indices of the systolic function. Their validity relies on an accurate determination of the global end-diastolic volume (GEDV). Due to an overestimation of GEDV using a femoral central venous catheter (CVC) a correction formula for indexed GEDV (GEDVI) has been implemented in the latest PiCCO™-algorithm. However, a recent study demonstrated that correction for femoral CVC does not pertain to pulmonary vascular permeability index PVPI, which is calculated of extravascular lung water EVLW and GEDV...
June 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26984445/electrocardiographic-characterization-of-ramucirumab-on-the-corrected-qt-interval-in-a-phase-ii-study-of-patients-with-advanced-solid-tumors
#10
Anthony J Olszanski, David C Smith, Luis H Camacho, John Thompson, Suresh S Ramalingam, R Donald Harvey, Luis Campos, David Ferry, Shande Tang, Ling Gao, Howard Safran
LESSONS LEARNED: Cardiotoxicity can be a serious complication of anticancer therapies. To enable earlier identification of drug-related cardiac effects, the International Conference on Harmonization (ICH) adopted the ICH E14 Guidelines for evaluating the potential for QT/corrected QT (QTc) interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs.The results of the evaluation of ramucirumab on the QT/QTc interval show a lack of effect on QTc prolongation in patients with advanced cancer...
April 2016: Oncologist
https://www.readbyqxmd.com/read/26861469/evaluation-of-the-potential-for-qtc-prolongation-in-patients-with-solid-tumors-receiving-nivolumab
#11
RANDOMIZED CONTROLLED TRIAL
Shruti Agrawal, Ian Waxman, Alexandre Lambert, Amit Roy, Raymond Darbenzio
PURPOSE: The fully human monoclonal antibody nivolumab binds to the programmed death-1 (PD-1) receptor, blocking interactions between PD-1 and its ligands on tumor cells and preventing T cell exhaustion in patients with cancer. The potential for corrected QT interval (QTc) prolongation was assessed in a subset of patients enrolled in a phase 2 dose-ranging study of nivolumab. METHODS: Triplicate 12-lead electrocardiograms (ECGs) obtained predose and post-dose were assessed by an independent ECG core laboratory...
March 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/26069253/improving-appearance-and-microbiologic-quality-of-broiler-carcasses-with-an-allostatic-modulator
#12
M E Rubio-García, M S Rubio-Lozano, E Ponce-Alquicira, C Rosario-Cortes, G M Nava, M P Castañeda-Serrano
An important priority of poultry producers is to guarantee animal welfare during animal production; however, broilers are exposed to unavoidable chronic stress (also known as allostasis) when they are captured, caged, and transported to the processing plant. This antemortem management causes allostatic load, animal injuries, and poor carcass quality. The aim of the present study was to evaluate the effects of an allostatic modulator (AM) on antemortem stress by measuring the appearance and microbiological quality of broiler carcasses...
August 2015: Poultry Science
https://www.readbyqxmd.com/read/25805719/design-of-a-coil-satellite-centrifuge-and-its-performance-on-counter-current-chromatographic-separation-of-4-methylumbelliferyl-sugar-derivatives-with-polar-organic-aqueous-two-phase-solvent-systems
#13
Kazufusa Shinomiya, Koji Tokura, Emiru Kimura, Midori Takai, Naoki Harikai, Kazunori Yoshida, Kazuhiro Yanagidaira, Yoichiro Ito
A new high-speed counter-current chromatograph, named coil satellite centrifuge (CSC), was designed and fabricated in our laboratory. The CSC apparatus produces the satellite motion such that the coiled column simultaneously rotates around the sun axis (the angular velocity, ω1), the planet axis (ω2) and the satellite axis (the central axis of the column) (ω3). In order to achieve this triplicate rotary motion without twisting of the flow tube, the rotation of each axis was determined by the following formula: ω1=ω2+ω3...
May 1, 2015: Journal of Chromatography. A
https://www.readbyqxmd.com/read/24854576/challenging-the-present-definition-of-normal-vitamin-d-levels-obtained-by-a-single-blood-test-can-we-develop-a-formula-to-predict-vitamin-d-levels-in-the-4-seasons-from-a-single-season-s-measure
#14
Howard Tandeter
Publications on the health effects of vitamin D (25(OH) D) had almost triplicate in the last 10years, not only for its known "calcemic effects" (calcium, phosphor, PTH), but for the more recent findings on its "non-calcemic effects" (all-cause and cardiovascular mortality, and relation with certain types of cancer). Part of these publications deal with the definition of what is a "normal" circulating level of 25(OH) D that may distinguish between health and disease. The literature also deals with seasonal variations of vitamin D, showing levels that rise in summer and fall in winter and with DBP phenotypes and geographical location that affect seasonality of 25(OH) D measurements...
August 2014: Medical Hypotheses
https://www.readbyqxmd.com/read/24326972/mathematical-coupling-of-data-between-global-end-diastolic-volume-index-and-cardiac-index-calculated-by-the-picco-device-myth-or-reality
#15
J Mallat, M Lemyze, J Salleron, Y Benzidi, S Barrailler, F Pepy, G Gasan, L Tronchon, D Thevenin
BACKGROUND: Aim of the study was to investigate whether cardiac index (CI) and global end diastolic volume index (GEDVi) determined from the same thermodilution curve are mathematically coupled during the infusion of an inotropic agent in critically ill patients. METHODS: Seventeen patients were prospectively studied. CI and GEDVi were evaluated in triplicate by the transpulmonary thermodilution technique with the PiCCO system before and 20 to 30 minutes after increases in dobutamine infusion rate...
September 2014: Minerva Anestesiologica
https://www.readbyqxmd.com/read/24056523/effect-of-the-counter-anion-on-the-spin-transition-properties-of-a-family-of-fe-ii-tetrazole-complexes-fe-i4tz-6-x2-x-clo4-pf6-sbf6-bf4
#16
Myrvete Tafili-Kryeziu, Matthias Weil, Takahiro Muranaka, Azzedine Bousseksou, Miki Hasegawa, Akimitsu Jun, Wolfgang Linert
The monodentate ligand 1-isobutyl-1H-tetrazole (i4tz) was used to synthesize a series of iron(II) spin-crossover (SCO) complexes with the general formula [Fe(i4tz)6]X2, where X = ClO4(-) (1), PF6(-) (2), SbF6(-) (3), or BF4(-) (4). Upon cooling, magnetic susceptibility measurements of compounds 1, 2 and 3 show a reversible one-step spin crossover (SCO) behaviour between HS (S = 2) and LS (S = 0) states without hysteresis. The ClO4(-) compound shows a gradual spin transition at T(1/2) = 208 K at a considerably higher temperature than the other compounds...
November 28, 2013: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24000756/vitamin-c-in-infant-formula-and-adult-pediatric-nutritional-formula-by-hplc-with-uv-detection-first-action-2012-21
#17
Karen Schimpf, Linda Thompson, Steve Baugh
This method for the determination of vitamin C by HPLC allows for the separation and quantitation of L-ascorbic acid in infant, pediatric, and adult nutritional products. Liquids, semisolids, and powders ranging from 2 to 1000 mg/kg in their consumable forms were analyzed during the method validation. The method met the standard method performance requirements and was approved by an AOAC Expert Review Panel on Infant Formula and Adult Nutritionals on October 2, 2012. During validation, the overall intermediate precision was 2...
July 2013: Journal of AOAC International
https://www.readbyqxmd.com/read/23722041/release-kinetics-of-platelet-derived-and-plasma-derived-growth-factors-from-autologous-plasma-rich-in-growth-factors
#18
Eduardo Anitua, Mari Mar Zalduendo, Mohammad Hamdan Alkhraisat, Gorka Orive
Many studies have evaluated the biological effects of platelet rich plasma reporting the final outcomes on cell and tissues. However, few studies have dealt with the kinetics of growth factor delivery by plasma rich in growth factors. Venous blood was obtained from three healthy volunteers and processed with PRGF-Endoret technology to prepare autologous plasma rich in growth factors. The gel-like fibrin scaffolds were then incubated in triplicate, in a cell culture medium to monitor the release of PDGF-AB, VEGF, HGF and IGF-I during 8 days of incubation...
October 2013: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/23210913/determining-the-osmolality-of-over-concentrated-and-supplemented-infant-formulas
#19
J R Steele, R J Meskell, J Foy, A E Garner
BACKGROUND: Hyperosmolar infant feeds can cause osmotic diarrhoea and may be a risk factor for necrotising enterocolitis; the osmolality of infant formula is therefore usually <400 mOsm kg(-1) . However, in fluid-restricted infants and those needing nutritional support, formulas may be over-concentrated or supplemented. The present study aimed to determine the effect of these practices on osmolality. METHODS: A clinical laboratory osmometer was used to measure the osmolality of infant formulas...
February 2013: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/23110574/characterization-of-dissolved-organic-matter-in-full-scale-continuous-stirred-tank-biogas-reactors-using-ultrahigh-resolution-mass-spectrometry-a-qualitative-overview
#20
COMPARATIVE STUDY
Sepehr Shakeri Yekta, Michael Gonsior, Philippe Schmitt-Kopplin, Bo H Svensson
Dissolved organic matter (DOM) was characterized in eight full scale continuous stirred tank biogas reactors (CSTBR) using solid-phase extraction and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR-MS). An overview of the DOM molecular complexity in the samples from biogas reactors with conventional operational conditions and various substrate profiles is provided by assignments of unambiguous exact molecular formulas for each measured mass peak. Analysis of triplicate samples for each reactor demonstrated the reproducibility of the solid-phase extraction procedure and ESI-FT-ICR-MS which allowed precise evaluation of the DOM molecular differences among the different reactors...
November 20, 2012: Environmental Science & Technology
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