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Triplice formula

Bruna Facinelli, Emanuela Marini, Gloria Magi, Lucia Zampini, Lucia Santoro, Carlo Catassi, Chiara Monachesi, Orazio Gabrielli, Giovanni V Coppa
BACKGROUND: It is well known that human milk oligosaccharides play an important role as prebiotics, anti-inflammatory, and anti-infective agents. In the last few years, several studies have been performed using specific oligosaccharides, such as 2'-fucosyllactose and 6'-sialylactose, to evaluate their biological functions. OBJECTIVES: The aim of the present study is to evaluate the anti-adhesive effect of the above oligosaccharides on Escherichia coli and Salmonella fyris...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
Polina German, Anita Mathias, Diana M Brainard, Qinghua Song, John Ling, Brian P Kearney
This study evaluated the effect of supratherapeutic exposure of the anti-HCV drug ledipasvir on the QTc interval in healthy subjects. Sixty healthy volunteers were randomized to receive twice-daily blinded ledipasvir (120 mg) or placebo, administered for 10 days each, or single doses of open-label moxifloxacin (400 mg). Serial plasma samples for ledipasvir concentration analysis were collected after each treatment. Triplicate time-matched electrocardiograms were collected at baseline and after each treatment...
October 23, 2017: Clinical Pharmacology in Drug Development
Wolfgang Huber, Andrea Gruber, Maximilian Eckmann, Felicia Elkmann, Ines Klein, Tobias Lahmer, Ulrich Mayr, Raphael Schellnegger, Jochen Schneider, Gonzalo Batres-Baires, Lisa Fekecs, Analena Beitz, Helena Berbara, Roland Schmid, Alexander Herner
BACKGROUND: Transpulmonary thermodilution (TPTD) is used to derive cardiac output CO, global end-diastolic volume GEDV and extravascular lung water EVLW. To facilitate interpretation of these data, several ratios have been developed, including pulmonary vascular permeability index (defined as EVLW/(0.25*GEDV)) and global ejection fraction ((4*stroke volume)/GEDV). PVPI and GEF have been associated to the aetiology of pulmonary oedema and systolic cardiac function, respectively. Several studies demonstrated that the use of femoral venous access results in a marked overestimation of GEDV...
2017: PloS One
K-C Xue, D-D Hu, L Zhao, N Li, H-Y Shen
OBJECTIVE: The objective of this study was to examine the correlation between the presence of primary iris-ciliary cysts and the intraocular pressure. PATIENTS AND METHODS: Sixty patients with short-sightedness undergoing routine examination for laser vision correction in our hospital in 2003 were enrolled. Patients with known high intraocular pressure and risk of glaucoma were excluded from the study. A total of 119 eyes were examined by the Ultrasound Biomicroscope (UBM), and the presence of the primary iris-ciliary cysts was confirmed...
September 2017: European Review for Medical and Pharmacological Sciences
J Täubel, G Ferber, S Fernandes, E Santamaría, I Izquierdo
A thorough QT/QTc study in healthy white Caucasian subjects demonstrated that rupatadine has no proarrhythmic potential and raised no cardiac safety concerns. The present phase 1 study aimed to confirm the cardiac safety of rupatadine in healthy Japanese subjects. In this randomized, double-blind, placebo-controlled study, 27 healthy Japanese subjects were administered single and multiple escalating rupatadine doses of 10, 20, and 40 mg or placebo. Triplicate electrocardiogram (ECG) recordings were performed on days -1, 1, and 5 at several points, and time-matched pharmacokinetic samples were also collected...
January 2018: Clinical Pharmacology in Drug Development
Maarten H G Heusinkveld, Sjeng Quicken, Robert J Holtackers, Wouter Huberts, Koen D Reesink, Tammo Delhaas, Bart Spronck
Quantification of the uncertainty in constitutive model predictions describing arterial wall mechanics is vital towards non-invasive assessment of vascular drug therapies. Therefore, we perform uncertainty quantification to determine uncertainty in mechanical characteristics describing the vessel wall response upon loading. Furthermore, a global variance-based sensitivity analysis is performed to pinpoint measurements that are most rewarding to be measured more precisely. We used previously published carotid diameter-pressure and intima-media thickness (IMT) data (measured in triplicate), and Holzapfel-Gasser-Ogden models...
February 2018: Biomechanics and Modeling in Mechanobiology
Marcio Antonio Mendonça, Wilma Maria Coelho Araújo, Luiz Antonio Borgo, Ernandes de Rodrigues Alencar
Situations including premature infants, or those in which there is a rejection to breastfeeding, require the use infant formulas for total or partial replacement of human milk. The objective of this study was to determine the lipid content and to identify the lipid profile of infant formulas. Samples were collected from ten different infant formulas, used as a substitute for breast milk at the Maternal and Child Hospital of Brasilia. The human milk sample consisted of a pool of samples from 10 mature milk donors at the milk bank of the University Hospital of Brasilia...
2017: PloS One
Valentin Saqué, Martino Vaglio, Christian Funck-Brentano, Maya Kilani, Olivier Bourron, Agnès Hartemann, Fabio Badilini, Joe-Elie Salem
BACKGROUND: The gold standard method for assessing the QTcF (QT corrected for heart rate by Fridericia's cube root formula) interval is the "QTcF semiautomated triplicate averaging method" (TAM), which consists of measuring three QTcF values semiautomatically, for each 10-second sequence of a triplicate electrocardiogram set, and averaging them to get a global and unique QTcF value. Thus, TAM is time consuming. We have developed a new method, namely the "QTcF semiautomated triplicate concatenation method" (TCM), which consists of concatenating the three 10-second sequences of the triplicate electrocardiogram set as if they were a single 30-second electrocardiogram, and measuring QTcF only once for the triplicate electrocardiogram set...
August 2017: Archives of Cardiovascular Diseases
Wijith P Munasinghe, Rajendar K Mittapalli, Hong Li, David M Hoffman, Kyle D Holen, Rajeev M Menon, Hao Xiong
PURPOSE: ABT-414 is an antibody-drug conjugate (ADC) being developed for the treatment of tumors harboring amplification of the epidermal growth factor receptor (EGFR). This study evaluated the potential of ABT-414 to prolong the QT interval as part of the initial phase 1 study (NCT01741727). METHODS: Data from patients who received ABT-414 monotherapy at a dose of 1-4 mg/kg once every 3 weeks or 1 or 1.5 mg/kg weekly for 2 out of every 3 weeks (alternate schedule) by intravenous infusion were included in the analysis of triplicate 12-lead ECGs obtained before dosing and through 168 h after dosing...
May 2017: Cancer Chemotherapy and Pharmacology
La'Toya V Latney, Barbara D Toddes, Nicole R Wyre, Dorothy C Brown, Kathryn E Michel, Johanna A Briscoe
OBJECTIVE To evaluate whether the nutritive quality of Tenebrio molitor larvae and Zophobas morio larvae, which are commonly cultured as live food sources, is influenced by 4 commercially available diets used as nutritional substrates; identify which diet best improved calcium content of larvae; and identify the feeding time interval that assured the highest calcium intake by larvae. ANIMALS 2,000 Zophobas morio larvae (ie, superworms) and 7,500 Tenebrio molitor larvae (ie, mealworms). PROCEDURES Larvae were placed in control and diet treatment groups for 2-, 7-, and 10-day intervals...
February 2017: American Journal of Veterinary Research
Kazufusa Shinomiya, Kazumasa Zaima, Yukina Harada, Miho Yasue, Naoki Harikai, Koji Tokura, Yoichiro Ito
Coil satellite centrifuge (CSC) produces the complex satellite motion consisting of the triplicate rotation of the coiled column around three axes including the sun axis (the angular velocity, ω1 ), the planet axis (ω2 ) and the satellite axis (the central axis of the column) (ω3 ) according to the following formula: ω1 =ω2 +ω3 . Improved peak resolution in the separation of 4-methylumbelliferyl sugar derivatives was achieved using the conventional multilayer coiled columns with ethyl acetate/1-butanol/water (3: 2: 5, v/v) for the lower mobile phase at the combination of the rotation speeds (ω1 , ω2 , ω3 )=(300, 150, 150rpm), and (1:4:5, v/v) for the upper mobile phase at (300:100:200rpm)...
January 20, 2017: Journal of Chromatography. A
María Celeste Schierano, María Alejandra Maine, María Cecilia Panigatti
The aim of this work was to evaluate the influence of different substrates in the performance of a horizontal flow constructed wetland employed in dairy farm wastewater treatment. Typha domingensis was chosen for this study due to its high productivity and efficiency in nutrient removal. Fifteen microcosm-scale reactors simulating horizontal flow constructed wetlands were disposed in a greenhouse in triplicate. Five substrates (river gravel, gravel, LECA, river gravel + zeolite and gravel + zeolite) were evaluated...
January 2017: Environmental Technology
Ryan T Hurt, Lisa M Epp, Adele K Pattinson, Wanda M Duellman, Stephen M Corner, Manpreet S Mundi
BACKGROUND: Enteral nutrition (EN) misconnections have been identified as a serious and potential deadly problem. An international effort led by EN industry leaders has developed a small-bore enteral connector (ENFit) that in theory will reduce the frequency of misconnections. Despite the potential benefit of preventing misconnections, the full impact of adoption of the ENFit connector is unknown. To assess the impact of transitioning to ENFit on our home EN (HEN) patients, the current study evaluated gravity feeding comparing 2 proposed small-bore connectors to the legacy (current connector) using various commercial formulas...
April 2017: Nutrition in Clinical Practice
Mehdi Najar, Mohammad Fayyad-Kazan, Hussein Fayyad-Kazan, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Due to its anti-inflammatory and immunosuppressive potential, Nitric oxide (NO), a gaseous radical, is of special importance during graft-versus-host diseases (GVHD) and feoto-maternal tolerance. NO is a major mediator of murine mesenchymal stromal cells (MSCs)-immunosuppressive capacity. In this data article, we characterized NO production by human bone marrow-derived MSCs (hBMSCs). MSCs, isolated from healthy donors (n=5), were defined according to the International Society for cellular Therapy (ISCT) guidelines...
September 2016: Data in Brief
Analena Beitz, Helena Berbara, Sebastian Mair, Benedikt Henschel, Tobias Lahmer, Sebastian Rasch, Roland Schmid, Wolfgang Huber
Global ejection fraction (GEF) and cardiac function index (CFI) are transpulmonary thermodilution (TPTD)-derived indices of the systolic function. Their validity relies on an accurate determination of the global end-diastolic volume (GEDV). Due to an overestimation of GEDV using a femoral central venous catheter (CVC) a correction formula for indexed GEDV (GEDVI) has been implemented in the latest PiCCO™-algorithm. However, a recent study demonstrated that correction for femoral CVC does not pertain to pulmonary vascular permeability index PVPI, which is calculated of extravascular lung water EVLW and GEDV...
June 2017: Journal of Clinical Monitoring and Computing
Anthony J Olszanski, David C Smith, Luis H Camacho, John Thompson, Suresh S Ramalingam, R Donald Harvey, Luis Campos, David Ferry, Shande Tang, Ling Gao, Howard Safran
LESSONS LEARNED: Cardiotoxicity can be a serious complication of anticancer therapies. To enable earlier identification of drug-related cardiac effects, the International Conference on Harmonization (ICH) adopted the ICH E14 Guidelines for evaluating the potential for QT/corrected QT (QTc) interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs.The results of the evaluation of ramucirumab on the QT/QTc interval show a lack of effect on QTc prolongation in patients with advanced cancer...
April 2016: Oncologist
Shruti Agrawal, Ian Waxman, Alexandre Lambert, Amit Roy, Raymond Darbenzio
PURPOSE: The fully human monoclonal antibody nivolumab binds to the programmed death-1 (PD-1) receptor, blocking interactions between PD-1 and its ligands on tumor cells and preventing T cell exhaustion in patients with cancer. The potential for corrected QT interval (QTc) prolongation was assessed in a subset of patients enrolled in a phase 2 dose-ranging study of nivolumab. METHODS: Triplicate 12-lead electrocardiograms (ECGs) obtained predose and post-dose were assessed by an independent ECG core laboratory...
March 2016: Cancer Chemotherapy and Pharmacology
M E Rubio-García, M S Rubio-Lozano, E Ponce-Alquicira, C Rosario-Cortes, G M Nava, M P Castañeda-Serrano
An important priority of poultry producers is to guarantee animal welfare during animal production; however, broilers are exposed to unavoidable chronic stress (also known as allostasis) when they are captured, caged, and transported to the processing plant. This antemortem management causes allostatic load, animal injuries, and poor carcass quality. The aim of the present study was to evaluate the effects of an allostatic modulator (AM) on antemortem stress by measuring the appearance and microbiological quality of broiler carcasses...
August 2015: Poultry Science
Kazufusa Shinomiya, Koji Tokura, Emiru Kimura, Midori Takai, Naoki Harikai, Kazunori Yoshida, Kazuhiro Yanagidaira, Yoichiro Ito
A new high-speed counter-current chromatograph, named coil satellite centrifuge (CSC), was designed and fabricated in our laboratory. The CSC apparatus produces the satellite motion such that the coiled column simultaneously rotates around the sun axis (the angular velocity, ω1), the planet axis (ω2) and the satellite axis (the central axis of the column) (ω3). In order to achieve this triplicate rotary motion without twisting of the flow tube, the rotation of each axis was determined by the following formula: ω1=ω2+ω3...
May 1, 2015: Journal of Chromatography. A
Howard Tandeter
Publications on the health effects of vitamin D (25(OH) D) had almost triplicate in the last 10years, not only for its known "calcemic effects" (calcium, phosphor, PTH), but for the more recent findings on its "non-calcemic effects" (all-cause and cardiovascular mortality, and relation with certain types of cancer). Part of these publications deal with the definition of what is a "normal" circulating level of 25(OH) D that may distinguish between health and disease. The literature also deals with seasonal variations of vitamin D, showing levels that rise in summer and fall in winter and with DBP phenotypes and geographical location that affect seasonality of 25(OH) D measurements...
August 2014: Medical Hypotheses
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