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https://www.readbyqxmd.com/read/27913774/gravity-flow-in-proposed-enteral-tube-small-bore-connectors
#1
Ryan T Hurt, Lisa M Epp, Adele K Pattinson, Wanda M Duellman, Stephen M Corner, Manpreet S Mundi
BACKGROUND: Enteral nutrition (EN) misconnections have been identified as a serious and potential deadly problem. An international effort led by EN industry leaders has developed a small-bore enteral connector (ENFit) that in theory will reduce the frequency of misconnections. Despite the potential benefit of preventing misconnections, the full impact of adoption of the ENFit connector is unknown. To assess the impact of transitioning to ENFit on our home EN (HEN) patients, the current study evaluated gravity feeding comparing 2 proposed small-bore connectors to the legacy (current connector) using various commercial formulas...
December 2, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27536712/data-on-nitric-oxide-production-by-human-bone-marrow-derived-mesenchymal-stromal-cells
#2
Mehdi Najar, Mohammad Fayyad-Kazan, Hussein Fayyad-Kazan, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Due to its anti-inflammatory and immunosuppressive potential, Nitric oxide (NO), a gaseous radical, is of special importance during graft-versus-host diseases (GVHD) and feoto-maternal tolerance. NO is a major mediator of murine mesenchymal stromal cells (MSCs)-immunosuppressive capacity. In this data article, we characterized NO production by human bone marrow-derived MSCs (hBMSCs). MSCs, isolated from healthy donors (n=5), were defined according to the International Society for cellular Therapy (ISCT) guidelines...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27103253/consistency-of-cardiac-function-index-and-global-ejection-fraction-with-global-end-diastolic-volume-in-patients-with-femoral-central-venous-access-for-transpulmonary-thermodilution-a-prospective-observational-study
#3
Analena Beitz, Helena Berbara, Sebastian Mair, Benedikt Henschel, Tobias Lahmer, Sebastian Rasch, Roland Schmid, Wolfgang Huber
Global ejection fraction (GEF) and cardiac function index (CFI) are transpulmonary thermodilution (TPTD)-derived indices of the systolic function. Their validity relies on an accurate determination of the global end-diastolic volume (GEDV). Due to an overestimation of GEDV using a femoral central venous catheter (CVC) a correction formula for indexed GEDV (GEDVI) has been implemented in the latest PiCCO™-algorithm. However, a recent study demonstrated that correction for femoral CVC does not pertain to pulmonary vascular permeability index PVPI, which is calculated of extravascular lung water EVLW and GEDV...
April 21, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26984445/electrocardiographic-characterization-of-ramucirumab-on-the-corrected-qt-interval-in-a-phase-ii-study-of-patients-with-advanced-solid-tumors
#4
Anthony J Olszanski, David C Smith, Luis H Camacho, John Thompson, Suresh S Ramalingam, R Donald Harvey, Luis Campos, David Ferry, Shande Tang, Ling Gao, Howard Safran
LESSONS LEARNED: Cardiotoxicity can be a serious complication of anticancer therapies. To enable earlier identification of drug-related cardiac effects, the International Conference on Harmonization (ICH) adopted the ICH E14 Guidelines for evaluating the potential for QT/corrected QT (QTc) interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs.The results of the evaluation of ramucirumab on the QT/QTc interval show a lack of effect on QTc prolongation in patients with advanced cancer...
April 2016: Oncologist
https://www.readbyqxmd.com/read/26861469/evaluation-of-the-potential-for-qtc-prolongation-in-patients-with-solid-tumors-receiving-nivolumab
#5
RANDOMIZED CONTROLLED TRIAL
Shruti Agrawal, Ian Waxman, Alexandre Lambert, Amit Roy, Raymond Darbenzio
PURPOSE: The fully human monoclonal antibody nivolumab binds to the programmed death-1 (PD-1) receptor, blocking interactions between PD-1 and its ligands on tumor cells and preventing T cell exhaustion in patients with cancer. The potential for corrected QT interval (QTc) prolongation was assessed in a subset of patients enrolled in a phase 2 dose-ranging study of nivolumab. METHODS: Triplicate 12-lead electrocardiograms (ECGs) obtained predose and post-dose were assessed by an independent ECG core laboratory...
March 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/26069253/improving-appearance-and-microbiologic-quality-of-broiler-carcasses-with-an-allostatic-modulator
#6
M E Rubio-García, M S Rubio-Lozano, E Ponce-Alquicira, C Rosario-Cortes, G M Nava, M P Castañeda-Serrano
An important priority of poultry producers is to guarantee animal welfare during animal production; however, broilers are exposed to unavoidable chronic stress (also known as allostasis) when they are captured, caged, and transported to the processing plant. This antemortem management causes allostatic load, animal injuries, and poor carcass quality. The aim of the present study was to evaluate the effects of an allostatic modulator (AM) on antemortem stress by measuring the appearance and microbiological quality of broiler carcasses...
August 2015: Poultry Science
https://www.readbyqxmd.com/read/25805719/design-of-a-coil-satellite-centrifuge-and-its-performance-on-counter-current-chromatographic-separation-of-4-methylumbelliferyl-sugar-derivatives-with-polar-organic-aqueous-two-phase-solvent-systems
#7
Kazufusa Shinomiya, Koji Tokura, Emiru Kimura, Midori Takai, Naoki Harikai, Kazunori Yoshida, Kazuhiro Yanagidaira, Yoichiro Ito
A new high-speed counter-current chromatograph, named coil satellite centrifuge (CSC), was designed and fabricated in our laboratory. The CSC apparatus produces the satellite motion such that the coiled column simultaneously rotates around the sun axis (the angular velocity, ω1), the planet axis (ω2) and the satellite axis (the central axis of the column) (ω3). In order to achieve this triplicate rotary motion without twisting of the flow tube, the rotation of each axis was determined by the following formula: ω1=ω2+ω3...
May 1, 2015: Journal of Chromatography. A
https://www.readbyqxmd.com/read/24854576/challenging-the-present-definition-of-normal-vitamin-d-levels-obtained-by-a-single-blood-test-can-we-develop-a-formula-to-predict-vitamin-d-levels-in-the-4-seasons-from-a-single-season-s-measure
#8
Howard Tandeter
Publications on the health effects of vitamin D (25(OH) D) had almost triplicate in the last 10years, not only for its known "calcemic effects" (calcium, phosphor, PTH), but for the more recent findings on its "non-calcemic effects" (all-cause and cardiovascular mortality, and relation with certain types of cancer). Part of these publications deal with the definition of what is a "normal" circulating level of 25(OH) D that may distinguish between health and disease. The literature also deals with seasonal variations of vitamin D, showing levels that rise in summer and fall in winter and with DBP phenotypes and geographical location that affect seasonality of 25(OH) D measurements...
August 2014: Medical Hypotheses
https://www.readbyqxmd.com/read/24326972/mathematical-coupling-of-data-between-global-end-diastolic-volume-index-and-cardiac-index-calculated-by-the-picco-device-myth-or-reality
#9
J Mallat, M Lemyze, J Salleron, Y Benzidi, S Barrailler, F Pepy, G Gasan, L Tronchon, D Thevenin
BACKGROUND: Aim of the study was to investigate whether cardiac index (CI) and global end diastolic volume index (GEDVi) determined from the same thermodilution curve are mathematically coupled during the infusion of an inotropic agent in critically ill patients. METHODS: Seventeen patients were prospectively studied. CI and GEDVi were evaluated in triplicate by the transpulmonary thermodilution technique with the PiCCO system before and 20 to 30 minutes after increases in dobutamine infusion rate...
September 2014: Minerva Anestesiologica
https://www.readbyqxmd.com/read/24056523/effect-of-the-counter-anion-on-the-spin-transition-properties-of-a-family-of-fe-ii-tetrazole-complexes-fe-i4tz-6-x2-x-clo4-pf6-sbf6-bf4
#10
Myrvete Tafili-Kryeziu, Matthias Weil, Takahiro Muranaka, Azzedine Bousseksou, Miki Hasegawa, Akimitsu Jun, Wolfgang Linert
The monodentate ligand 1-isobutyl-1H-tetrazole (i4tz) was used to synthesize a series of iron(II) spin-crossover (SCO) complexes with the general formula [Fe(i4tz)6]X2, where X = ClO4(-) (1), PF6(-) (2), SbF6(-) (3), or BF4(-) (4). Upon cooling, magnetic susceptibility measurements of compounds 1, 2 and 3 show a reversible one-step spin crossover (SCO) behaviour between HS (S = 2) and LS (S = 0) states without hysteresis. The ClO4(-) compound shows a gradual spin transition at T(1/2) = 208 K at a considerably higher temperature than the other compounds...
November 28, 2013: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24000756/vitamin-c-in-infant-formula-and-adult-pediatric-nutritional-formula-by-hplc-with-uv-detection-first-action-2012-21
#11
Karen Schimpf, Linda Thompson, Steve Baugh
This method for the determination of vitamin C by HPLC allows for the separation and quantitation of L-ascorbic acid in infant, pediatric, and adult nutritional products. Liquids, semisolids, and powders ranging from 2 to 1000 mg/kg in their consumable forms were analyzed during the method validation. The method met the standard method performance requirements and was approved by an AOAC Expert Review Panel on Infant Formula and Adult Nutritionals on October 2, 2012. During validation, the overall intermediate precision was 2...
July 2013: Journal of AOAC International
https://www.readbyqxmd.com/read/23722041/release-kinetics-of-platelet-derived-and-plasma-derived-growth-factors-from-autologous-plasma-rich-in-growth-factors
#12
Eduardo Anitua, Mari Mar Zalduendo, Mohammad Hamdan Alkhraisat, Gorka Orive
Many studies have evaluated the biological effects of platelet rich plasma reporting the final outcomes on cell and tissues. However, few studies have dealt with the kinetics of growth factor delivery by plasma rich in growth factors. Venous blood was obtained from three healthy volunteers and processed with PRGF-Endoret technology to prepare autologous plasma rich in growth factors. The gel-like fibrin scaffolds were then incubated in triplicate, in a cell culture medium to monitor the release of PDGF-AB, VEGF, HGF and IGF-I during 8 days of incubation...
October 2013: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/23210913/determining-the-osmolality-of-over-concentrated-and-supplemented-infant-formulas
#13
J R Steele, R J Meskell, J Foy, A E Garner
BACKGROUND: Hyperosmolar infant feeds can cause osmotic diarrhoea and may be a risk factor for necrotising enterocolitis; the osmolality of infant formula is therefore usually <400 mOsm kg(-1) . However, in fluid-restricted infants and those needing nutritional support, formulas may be over-concentrated or supplemented. The present study aimed to determine the effect of these practices on osmolality. METHODS: A clinical laboratory osmometer was used to measure the osmolality of infant formulas...
February 2013: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/23110574/characterization-of-dissolved-organic-matter-in-full-scale-continuous-stirred-tank-biogas-reactors-using-ultrahigh-resolution-mass-spectrometry-a-qualitative-overview
#14
COMPARATIVE STUDY
Sepehr Shakeri Yekta, Michael Gonsior, Philippe Schmitt-Kopplin, Bo H Svensson
Dissolved organic matter (DOM) was characterized in eight full scale continuous stirred tank biogas reactors (CSTBR) using solid-phase extraction and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR-MS). An overview of the DOM molecular complexity in the samples from biogas reactors with conventional operational conditions and various substrate profiles is provided by assignments of unambiguous exact molecular formulas for each measured mass peak. Analysis of triplicate samples for each reactor demonstrated the reproducibility of the solid-phase extraction procedure and ESI-FT-ICR-MS which allowed precise evaluation of the DOM molecular differences among the different reactors...
November 20, 2012: Environmental Science & Technology
https://www.readbyqxmd.com/read/22959867/effects-of-age-and-chronic-kidney-disease-on-regional-aortic-distensibility-a-cardiovascular-magnetic-resonance-study
#15
RANDOMIZED CONTROLLED TRIAL
Colin D Chue, Nicola C Edwards, Charles J Ferro, Jonathan N Townend, Richard P Steeds
BACKGROUND: Chronic kidney disease (CKD) is associated with increased arterial stiffness, an independent predictor of adverse cardiovascular outcome. Effects of CKD on regional aortic stiffness are unknown. This study aimed to determine the effects of CKD and ageing on regional thoracic aortic distensibility using cardiac magnetic resonance (CMR) imaging. METHODS: This was a cross-sectional case control study comparing patients with stage II-IV non-diabetic CKD recruited from a university hospital with healthy controls...
October 9, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/22917853/effects-of-a-supratherapeutic-dose-of-investigational-orally-inhaled-dihydroergotamine-map0004-on-qt-interval-a-randomized-double-blind-active-and-placebo-controlled-crossover-study-in-healthy-volunteers
#16
RANDOMIZED CONTROLLED TRIAL
Shashidhar Kori, Donald J Kellerman, Polina Voloshko, Gregory Haugen
BACKGROUND: MAP0004 is an orally inhaled investigational drug containing dihydroergotamine (DHE). Although DHE has been used for 60 years with no reported cardiac arrhythmias, a thorough QT study had not previously been performed with DHE. OBJECTIVE: The objective of this study was to assess the effects of MAP0004 on the QT interval as required for regulatory approval of a new product. METHODS: This randomized, double-blind, placebo-controlled, 3-period crossover study enrolled healthy volunteers...
September 2012: Clinical Therapeutics
https://www.readbyqxmd.com/read/22837756/quantification-of-ammonia-oxidation-rates-and-the-distribution-of-ammonia-oxidizing-archaea-and-bacteria-in-marine-sediment-depth-profiles-from-catalina-island-california
#17
J M Beman, Victoria J Bertics, Thomas Braunschweiler, Jesse M Wilson
Microbial communities present in marine sediments play a central role in nitrogen biogeochemistry at local to global scales. Along the oxidation-reduction gradients present in sediment profiles, multiple nitrogen cycling processes (such as nitrification, denitrification, nitrogen fixation, and anaerobic ammonium oxidation) are active and actively coupled to one another - yet the microbial communities responsible for these transformations and the rates at which they occur are still poorly understood. We report pore water geochemical (O(2), [Formula: see text], and [Formula: see text]) profiles, quantitative profiles of archaeal and bacterial amoA genes, and ammonia oxidation rate measurements, from bioturbated marine sediments of Catalina Island, California...
2012: Frontiers in Microbiology
https://www.readbyqxmd.com/read/22619925/antimicrobial-activity-of-the-extracts-from-benchalokawichian-remedy-and-its-components
#18
Supaluck Nuaeissara, Sumalee Kondo, Arunporn Itharat
BACKGROUND: Infectious diseases cause serious health problems worldwide due to multiresistant bacterial strains. Thai traditional formula such as Benchalokawichian remedy has been used to relieve fever, common cold and influenza. The remedy has been scientifically proved for antipyretic and antiseptic activities. However; the remedy and its components have not been fully studied for antimicrobial activity against pathogenic bacteria. OBJECTIVE: To determine antimicrobial activity of extracts from Benchalokawichian remedy and its components against clinical isolates by disk diffusion method...
December 2011: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/21819440/fluoride-content-of-ready-to-feed-rtf-infant-food-and-drinks-in-the-uk
#19
Anne Maguire, Narges Omid, Lamis Abuhaloob, Paula J Moynihan, Fatemeh V Zohoori
BACKGROUND: The level of Fluoride exposure needed to cause dental fluorosis is not known precisely. An awareness of total F intake from all sources, especially during the critical stages of dental development during infancy and early childhood, is important in preventing the development of dental fluorosis. OBJECTIVES: The aim of the study was to measure F content of ready-to-feed (RTF) infant drinks and foods in the UK. METHODS: In total, 122 infant foods were analysed for F concentrations, in triplicate, indirectly by an acid diffusion method and 25 infant drinks analysed directly using an F-ion-selective electrode after addition of TISABIII...
February 2012: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/21521237/effect-of-dexmedetomidine-on-the-minimum-alveolar-concentration-of-isoflurane-in-cats
#20
A Escobar, B H Pypendop, K T Siao, S D Stanley, J E Ilkiw
This study reports the effects of dexmedetomidine on the minimum alveolar concentration of isoflurane (MAC(iso) ) in cats. Six healthy adult female cats were used. MAC(iso) and dexmedetomidine pharmacokinetics had previously been determined in each individual. Cats were anesthetized with isoflurane in oxygen. Dexmedetomidine was administered intravenously using target-controlled infusions to maintain plasma concentrations of 0.16, 0.31, 0.63, 1.25, 2.5, 5, 10, and 20 ng/mL. MAC(iso) was determined in triplicate at each target plasma dexmedetomidine concentration...
April 2012: Journal of Veterinary Pharmacology and Therapeutics
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