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https://www.readbyqxmd.com/read/29786154/topical-polyhydroxy-acid-treatment-for-autosomal-recessive-congenital-ichthyosis-in-the-golden-retriever-a-prospective-pilot-study
#1
Anna Puigdemont, Nicla Furiani, Michela De Lucia, Isaac Carrasco, Laura Ordeix, Dolors Fondevila, Laura Ramió-Lluch, Pilar Brazis
BACKGROUND: Autosomal recessive congenital ichthyosis (ARCI) in golden retrievers is due to a PNPLA1 gene mutation, which plays a role in epidermal lipid organization and metabolism. Topical therapies are used to reduce scaling; however, there are few published efficacy studies. OBJECTIVES: To examine the efficacy of topical treatment based on gluconolactone, a polyhydroxy acid with known beneficial effects on stratum corneum structure. ANIMALS: Sixteen golden retriever dogs with clinical signs of ARCI and PCR-confirmed PNPLA1 gene mutation...
May 22, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29785318/role-of-nanotechnology-in-cosmeceuticals-a-review-of-recent-advances
#2
REVIEW
Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, Upendra Nagaich
Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use...
2018: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29785134/the-impact-of-acne-and-facial-post-inflammatory-hyperpigmentation-on-quality-of-life-and-self-esteem-of-newly-admitted-nigerian-undergraduates
#3
Adeolu Oladayo Akinboro, Ogochukwu Ifeanyi Ezejiofor, Fatai Olatunde Olanrewaju, Mufutau Muphy Oripelaye, Olatunde Peter Olabode, Olugbenga Edward Ayodele, Emmanuel Olaniyi Onayemi
Background: Acne and facial post-inflammatory hyperpigmentation are relatively common clinical conditions among adolescents and young adults, and inflict psychosocial injuries on sufferers. Objective: To document the psychosocial and self-esteem implications of acne and facial hyperpigmentation on newly admitted undergraduates. Materials and methods: A cross-sectional survey was conducted among 200 undergraduates. Demographics and clinical characteristics were obtained and acne was graded using the US Food and Drug Administration 5-category global system of acne classification...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#4
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782300/poikilodermatous-mycosis-fungoides-rare-entity-different-treatment-modalities
#5
Sandra Jerković Gulin, Romana Čeović, Ivana Ilić, Mirna Bradamante, Zrinka Bukvić Mokos, Krešimir Kostović
Poikilodermatous mycosis fungoides (PMF) is a rare clinical variant of early-stage MF with peculiar histological features. Poikiloderma occurs in many different clinical conditions, which makes a diagnostic procedure more complicated. PMF belongs to a group of MF variants with low risk of disease progression. We report a case of a 64-year-old woman, who presented with mottled skin aspect of erythema, poikilodermatous patches (hypopigmentation, hyperpigmentation, atrophy, and telangiectasia) on more than 80% of the body...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29774634/study-of-hyperpigmentation-in-human-skin-disorder-using-different-electron-microscopy-techniques
#6
Seulgi Noh, Hyosun Choi, Ji Soo Kim, Il-Hwan Kim, Ji Young Mun
There is a global trend of increase in the demand for three-dimensional electron microscopy with high resolution. The ultrastructural change and related functional studies are necessary to investigate biological phenomena. In this study, currently available 3D reconstruction techniques of electron microscopes (serial block-face scanning electron microscopy and focused ion beam-scanning electron microscopy) were used to investigate hyperpigmentary disorders in human skin. In the basal layer of the epidermis in the human skin, there are melanocytes that produce melanin and keratinocytes that act as a barrier against environmental damage...
May 18, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29772369/sciatic-neuralgia-caused-by-may-thurner-syndrome-case-report
#7
Kazuaki Yamamoto, Gakuji Gondo, Hidemitsu Ogino, Tsuyoshi Watanabe, Masahiko Tanaka, Satoshi Tanaka, Taisuke Kawasaki
BACKGROUND: Sciatic neuralgia (SN) is a type of pain commonly associated with lumbosacral radiculopathy. May-Thurner syndrome (MTS) is a disease characterized by venous congestion in the left common iliac vein (LCIV) due to right common iliac artery compression. In this report, the authors describe a case of MTS with SN as the first presenting symptom. CASE DESCRIPTION: A 53-year-old man gradually developed left SN; however, radiological examination showed no causal findings...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29767467/treatment-of-periorbital-dark-circles-comparative-study-of-carboxy-therapy-vs-chemical-peeling-vs-mesotherapy
#8
Naglaa A Ahmed, Salma S Mohammed, Mohammad I Fatani
OBJECTIVE: Evaluation and comparison of the efficacy and safety of 3 different modalities of treatment for dark circles that function via different modes of action. METHODS: In total, 45 female patients with periorbital hyperpigmentation were randomly selected to participate from those attending the outpatient dermatology clinic of Al-Zahraa University Hospital within a 6-month period. Patients were divided into 3 groups, and the groups were subjected to different types of therapy: group A, carboxy therapy; group B, chemical peel; and group C, vitamin C mesotherapy...
May 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29763487/painful-violaceous-nodule-with-peripheral-hyperpigmentation
#9
Brian S Hoyt, Amin Hedayat, Robert E LeBlanc, Jonathan S Glass
No abstract text is available yet for this article.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29755554/evaluation-of-antioxidant-and-anti-melanogenic-activity-of-different-extracts-of-aerial-parts-of-n-sintenisii-in-murine-melanoma-b16f10-cells
#10
Maryam Akaberi, Seyed Ahmad Emami, Mohsen Vatani, Zahra Tayarani-Najaran
Nepeta (Lamiaceae) is an important genus with beneficial medicinal properties. N. sintenisii Bornm. has been used in folk medicine of Iran to cure various diseases. We investigated the anti-melanogenesis effects of n -hexane, MeOH, CH2 Cl2 , n -BuOH, EtOAc, and H2 O extracts isolated from the plant in B16 melanoma cells. Various assays including cytotoxicity, mushroom tyrosinase inhibition, inhibition of cellular tyrosinase, melanin content, the amount of reactive oxygen species and western blotting were done to assess the plant activities on melanogenesis inhibition...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29748107/green-bone-minocycline-induced-discoloration-of-bone-rarely-reported-in-foot-and-ankle
#11
Molly S Judge, J Michael Miller, Michael Lyons
The tetracycline antibiotics incorporate into bone similar to bisphosphonates. Tetracycline stains bone a fluorescent yellow and minocycline, more commonly used for chronic acne, stains bone dark green. Owing to its frequent use, the occurrence of green bone discoloration due to antibiotics in the tetracycline class is well understood. Its pigmentation can be seen through delicate, thin tissue as a dark blue-gray. Histologic inspection of this bone will confirm a benign condition without evidence of bone disease...
May 7, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29739761/long-lasting-remission-in-a-case-of-cronkhite-canada-syndrome
#12
Maria Pina Dore, Rosanna Satta, Alberto Murino, Giovanni Mario Pes
Cronkhite-Canada syndrome is a rare disease characterised by diffuse gastrointestinal polyposis, diarrhoea, weight loss, skin hyperpigmentation, onychodystrophy and alopecia. More than 500 cases have been described in the medical literature so far. The disease is probably caused by immune-mediated inflammatory mechanisms, and the diagnosis is based on clinical history, physical examination, endoscopic findings and histology. Differentiating this condition from other clinical entities presenting with similar signs and symptoms may be challenging...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29737897/successful-treatment-of-intravenous-drug-use-related-pigmentation-with-q-switched-alexandrite-laser-a-case-report-of-two-patients
#13
Stephen Akihiro Wirya, Neelam A Vashi
Patients with a history of intravenous drug usage (IVDU) often develop pathognomonic linear hyperpigmented dermatoses near injection sites. This drug use-related pigmentation can be very distressing for patients as they persist for life, are very difficult to treat, and remain a constant reminder of prior drug usage. The difficulty of treatment is due to the location of the deposited material and its exogenous nature. This article reports two cases of linear hyperpigmentation due to IVDU successfully treated using the Q-switched Alexandrite laser...
May 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29735364/methyl-2-acetylamino-3-4-hydroxyl-3-5-dimethoxybenzoylthio-propanoate-suppresses-melanogenesis-through-erk-signaling-pathway-mediated-mitf-proteasomal-degradation
#14
Ji Hoon Ha, Yoon Ju Jeong, Song Hua Xuan, Jae-Young Lee, Jino Park, Soo Nam Park
BACKGROUND: Microphthalmia-associated transcription factor (MITF) is regulated by expression and/or degradation pathway, controlling to the expression of melanogenic enzymes for melanin synthesis. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate (MAHDP) is reported to anti-melanogenesis effect but its mechanism remain unclear. OBJECTIVE: To investigate the effects of MAHDP on melanogenesis and elucidate its mechanism. METHODS: Tyrosinase activity, melanogenic proteins and gene expression levels were measured with MAHDP treatment in B16F1 cells, human melanocytes, reconstructed skin and clinical trial...
April 22, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29731588/resurfacing-of-facial-acne-scars-with-a-new-variable-pulsed-er-yag-laser-in-fitzpatrick-skin-types-iv-and-v
#15
Namitha Chathra, Venkataram Mysore
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29730144/reversible-hyperpigmentation-and-paraparesis-a-simple-remedy
#16
Ashish Agarwal, Arushi Gahlot Saini, Savita Attri
No abstract text is available yet for this article.
May 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29729698/poria-cocos-wolf-extracts-represses-pigmentation-in-vitro-and-in-vivo
#17
HyunKyung Lee, Hwa Jun Cha
In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and UV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. In our present study, we show that Poria cocos Wolf extracts decreased melanin synthesis in B16F10...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29726114/high-fluence-1064-nm-q-switched-nd-yag-laser-safe-and-effective-treatment-of-caf%C3%A3-au-lait-macules-in-asian-patients
#18
Jin Ok Baek, Il-Joong Park, Kyung Real Lee, Ha Ryeong Ryu, Jeongsoo Kim, Seulki Lee, Yu Ri Kim, Hoon Hur
OBJECTIVES: Café-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. To investigate the efficacy and safety of a high-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients...
May 3, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29723433/standardized-extract-of-wild-apple-fruit-in-alkyl-polyglucoside-based-cosmetic-cream-estimation-of-stability-safety-antioxidant-activity-and-efficiency
#19
Dragana Stojiljković, Vanja Tadić, Milica Stanković, Sonja Roganović, Ivana Arsić
OBJECTIVE: The aim of this study was in vitro and in vivo characterization of cosmetic cream with 6% of wild apple fruit water extract, containing 3.5% of alpha-hydroxyacids-AHAs and polyphenolic compounds, stabilized by biodegradable alkyl-polyglucoside emulsifiers. METHODS: In vitro characterization of cream included organoleptic and physico-chemical (pH values and electrical conductivity) analysis, antioxidant activity-AA estimation (using DPPH test) during 180 days of storage at 22±2°C and determination of cosmetic active substances content-AHAs (using HPLC analysis)...
May 3, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29714655/localized-morphea-after-breast-implant-for-breast-cancer-a-case-report
#20
A Moretti, F Bianchi, I V Abbate, G Gherardi, M Bonavita, E Passoni, G Nazzaro, A Bramati, M C Dazzani, S Piva, E Paternò, N Frungillo, G Farina, N La Verde
PURPOSE: Early breast cancer follow-up guidelines for patients who underwent surgery suggest a regular and accurate clinical examination of the breast area, for an early identification of cutaneous or subcutaneous breast cancer relapse. Nonetheless, breast skin lesions arising in patients treated with mastectomy for breast cancer can be caused by several diseases. A series of diagnostic hypotheses should be considered, not only focusing on cutaneous metastasis, but also on dermatologic and systemic diseases...
March 1, 2018: Tumori
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