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Shan zhongyan

Xiaomei Zhang, Baoting Yao, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Xiaochun Teng, Cheng Han, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Liu Yang, Chenling Fan, Weiping Teng, Zhongyan Shan
BACKGROUND: Self-sequential longitudinal reference interval may be expected to minimize the inter-individual variation of thyroid function. Comparison between self-sequential longitudinal reference interval and cross-sectional reference interval in pregnancy has not been well investigated. The objective of this study is to establish a stringent self-sequential longitudinal reference interval (SLRI) of thyroid function in pregnant women and to compare it with the conventional cross-sectional reference interval (CSRI)...
October 12, 2016: Thyroid: Official Journal of the American Thyroid Association
Yaxin Lai, Haoyu Wang, Xinghai Xia, Zhaojun Wang, Chenling Fan, Hong Wang, Hongmei Zhang, Shuangning Ding, Weiping Teng, Zhongyan Shan
As a newly emerging metabolic regulator, accumulating evidence suggests that the circulating fibroblast growth factor 19 (FGF19) level correlated with lipid and glucose metabolism. Several independent groups have found that FGF19 was highly likely associated with multiple metabolic disorders. Thyroid dysfunction is believed to be associated with metabolism diseases. However, to date, few studies have investigated the role of FGF19 in patients with thyroid dysfunctions. For this purpose, a cross-sectional study was done to estimate the role of FGF19 in patients with different thyroid functions...
September 2016: Medicine (Baltimore)
Xiaowen Zhang, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Shiqiao Peng, Zhaojun Wang, Cheng Han, Xiaomei Zhang, Danyang Wang, Chenling Fan, Zhongyan Shan, Weiping Teng
OBJECTIVES: To describe the changes in thyroglobulin (Tg) based upon gestational and postpartum concentrations in healthy pregnant women from an iodine-sufficient region in China, and to evaluate the use of Tg as a biomarker for iodine-sufficient pregnant women. DESIGN: A longitudinal study of Tg change in normal pregnant women from an iodine-sufficient region. PATIENTS AND MEASUREMENTS: Blood and urine samples were obtained from 133 pregnant women...
August 13, 2016: Clinical Endocrinology
Jianping Weng, Linong Ji, Weiping Jia, Juming Lu, Zhiguang Zhou, Dajin Zou, Dalong Zhu, Liming Chen, Li Chen, Lixin Guo, Xiaohui Guo, Qiuhe Ji, Qifu Li, Xiaoying Li, Jing Liu, Xingwu Ran, Zhongyan Shan, Lixin Shi, Guangyao Song, Liyong Yang, Yuzhi Yang, Wenying Yang
No abstract text is available yet for this article.
July 2016: Diabetes/metabolism Research and Reviews
Ye Yu, Jing Dong, Yuan Wang, Yi Wang, Hui Min, Zhongyan Shan, Weiping Teng, Jie Chen
Iodine deficiency (ID) during early pregnancy had an adverse effect on children's psychomotor and motor function. It is worth noting that maternal marginal ID tends to be a common public health problem. Whether marginal ID potentially had adverse effects on the development of cerebellum and the underlying mechanisms remain unclear. Therefore, our aim was to study the effects of marginal ID on the dendritic growth in filial cerebellar Purkinje cells (PCs) and the underlying mechanism. In the present study, we established Wistar rat models by feeding dam rats with a diet deficient in iodine and deionized water supplemented with potassium iodide...
July 22, 2016: Environmental Toxicology
Xiaojing Jin, Shujun Wang, Xuemin Zhao, Qian Jin, Chenling Fan, Jing Li, Zhongyan Shan, Weiping Teng
Coumestrol is a common phytoestrogen found in plants and Chinese medicinal herbs. Its influences on experimental autoimmune thyroiditis (EAT) were investigated in this study. Female adult CBA/J mice were fed with drinking water containing 1% Tween80 only (Control group), 0.8 mg/l (L group) and 8 mg/l coumestrol (H group) from 6 to 15 weeks of age, respectively. Their serum coumestrol concentrations were determined by high performance liquid chromatography, which were undetectable, 43.70 ± 21.74 ng/ml and 135...
June 30, 2016: Oncotarget
Zhongyan Shan, Lulu Chen, Xiaolan Lian, Chao Liu, Bingyin Shi, Lixin Shi, Nanwei Tong, Shu Wang, Jianping Weng, Jiajun Zhao, Xiaochun Teng, Xiaohui Yu, Yaxin Lai, Weiwei Wang, Chenyan Li, Jinyuan Mao, Yongze Li, Chenling Fan, Weiping Teng
BACKGROUND: The goal of eliminating iodine deficiency worldwide was successfully achieved in China after the implementation of a mandatory universal salt iodization program for the last 16 years. Thus, China has been assessed as a country with more than adequate iodine levels. This survey aimed to investigate the current iodine status in China and the effects of an increased iodine intake on the spectrum and prevalence of thyroid disorders. METHODS: A total of 15,008 adult subjects from 10 cities in eastern and central China were investigated...
August 2016: Thyroid: Official Journal of the American Thyroid Association
Haoyu Wang, Yaxin Lai, Cheng Han, Aihua Liu, Chenling Fan, Hong Wang, Hongmei Zhang, Shuangning Ding, Weiping Teng, Zhongyan Shan
ANGPTL8/betatrophin is a recently discovered hormone, which mainly synthesized and secreted by liver and adipose tissue, playing a critical role in pancreatic beta cell proliferation. Previous studies have suggested that serum ANGPTL8/betatrophin levels are associated with obesity and diabetes mellitus. Here, we evaluated the prospective association between ANGPTL8/betatrophin and the metabolic syndrome from a community-based cohort of 153 adults without metabolic syndrome. After 3.5-year follow-up, we observed an inverse correlation between the baseline ANGPTL8/betatrophin levels and the incidence of metabolic syndrome, even after multivariate adjustments...
2016: Scientific Reports
Meng Zhao, Lu Liu, Fei Wang, Zhongshang Yuan, Xu Zhang, Chao Xu, Yongfeng Song, Qingbo Guan, Ling Gao, Zhongyan Shan, Haiqing Zhang, Jiajun Zhao
BACKGROUND: Mild subclinical hypothyroidism (SCH) affects a large number of people and is known to be a risk factor for dyslipidemia. However, whether mild SCH patients should be treated with L-thyroxine to improve lipid profiles remains controversial. In addition, it is also unclear whether all mild SCH patients can benefit from L-thyroxine treatment, regardless of basal thyrotropin or lipid levels. This study aimed to assess the effects of L-thyroxine replacement therapy on the lipid profiles of mild SCH patients...
August 2016: Thyroid: Official Journal of the American Thyroid Association
Linong Ji, Qing Su, Bo Feng, Zhongyan Shan, Renming Hu, Xiaoping Xing, Yaoming Xue, Tao Yang, Yanyin Hua
BACKGROUD: Utilization of self-monitoring of blood glucose (SMBG) among patients with insulin-treated, type 2 diabetes (T2DM) in China is suboptimal. We evaluated the effectiveness of a structured SMBG for improving glycemic control and increasing the frequency of SMBG. METHODS: Insulin-treated (>3 months), T2DM patients aged >18 years with HbA1c > 8.0% (64 mmol/mol) were recruited. They received SMBG materials and were advised on a structured SMBG regimen for their insulin therapy...
June 1, 2016: Journal of Diabetes
Xiaona Hu, Ranran Wang, Zhongyan Shan, Yujie Dong, Hongzhi Zheng, Forrest Fabian Jesse, Elizabeth Rao, Eiki Takahashi, Weidong Li, Weiping Teng, Xiaochun Teng
BACKGROUND: Both perinatal hypothyroxinemia and perinatal iron deficiency (ID) are associated with poor neurodevelopment in offspring. Iron is an important component of thyroid peroxidase, a key enzyme in the synthesis of thyroid hormone. The authors' previous study demonstrated that perinatal ID can lead to maternal hypothyroxinemia during pregnancy. The goal of this study was to determine whether perinatal ID-associated hypothyroxinemia can cause brain defects prior to neonatal brain iron depletion...
July 2016: Thyroid: Official Journal of the American Thyroid Association
Cheng Han, Xinghai Xia, Aihua Liu, Xiaowen Zhang, Mi Zhou, Chuhui Xiong, Xin Liu, Jie Sun, Xiaoguang Shi, Zhongyan Shan, Weiping Teng
Thyroid hormone (TH) affects many metabolic processes such as promoting oxidation of sugar, fat, and protein in many tissues. Thyroid dysfunction is associated with metabolic disorders. The newly discovered adipocyte- and hepatocyte-derived cytokine, betatrophin, has been reported to be involved in metabolic diseases, but its influence on thyroid dysfunction is uncertain. Therefore, the present study aims to evaluate circulating betatrophin levels in subjects with different thyroid function status and to predict the factors associated with betatrophin levels, especially whether thyroid stimulating hormone (TSH), TH, or thyroid autoantibodies are associated with betatrophin levels...
2016: BioMed Research International
Zhao Tong, Zhang Xiaowen, Chen Baomin, Liu Aihua, Zhou Yingying, Teng Weiping, Shan Zhongyan
The objective of this study was to evaluate the association between maternal subclinical thyroid dysfunction and autoimmunity with the risk for intrauterine growth restriction (IUGR).Design is a systematic review and meta-analysis.A literature search was conducted using PubMed, Embase, and Cochrane database. A combination of 2 key words was used to search for the eligible studies: one indexed thyroid dysfunction or antithyroid antibodies; and the other one indexed the adverse neonatal outcomes of pregnancy, such as IUGR, small for gestational age, fetal growth restriction, or low birth weight...
May 2016: Medicine (Baltimore)
Xiaowen Zhang, Yaqiu Jiang, Wenqing Han, Aihua Liu, Xiaochen Xie, Cheng Han, Chenling Fan, Hong Wang, Hongmei Zhang, Shuangning Ding, Zhongyan Shan, Weiping Teng
The purpose of this study is to determine the effect of prolonged iodine overdose on type 2 iodothyronine deiodinase (D2) ubiquitination-related enzymes. Male Wistar rats were fed different doses of iodine and were then euthanized at the 4, 8, 12, or 24 weeks (4w, 8w, 12w, or 24w) after iodine administration. Urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), total thyroxine (TT4), and total triiodothyronine (TT3) were determined. Real-time quantitative RT-PCR and Western blot were used to measure mRNA and protein expression levels of pituitary D2 as well as two D2-specific ubiquitin ligases [WD repeat and SOCS box-containing protein 1 (WSB-1), membrane-associated ring finger (C3HC4) 6 (MARCH6 or TEB4)] and two D2-specific deubiquitinating enzymes [ubiquitin-specific peptidase 20 (USP20) and ubiquitin-specific peptidase 33 (USP33)]...
May 7, 2016: Biological Trace Element Research
Zhigang Zhao, Linong Ji, Lili Zheng, Liyong Yang, Huijuan Yuan, Li Chen, Zhongyan Shan, Shanmei Shen, Qiang Li, Bingyin Shi, Yanjun Liu, Qiuhe Ji, Yuqian Bao, Xin Gao, Yun Xie, Yuping Liu, Lulu Chen, Xueyao Han, Fang Wu, Chuan Yang, Jin Du, Ying Gao, Dajin Zou
AIM: This study explored the possibility of developing an alternative, simple and rapid test for the screening of distal symmetrical polyneuropathy (DSPN), for use in local primary care facilities. METHODS: 4023 patients with type 2 diabetes mellitus (T2DM), aged 18-80 years, from 21 hospitals in China were screened for inclusion in a prospective diagnostic assessment of DSPN, between April 2011 and March 2012. Patients underwent nerve conduction study (NCS; as the gold standard) and clinical assessments of ankle reflexes (AR) and thermal (T), vibration (V), pressure (P), and pinprick (PP) sensations...
May 2016: Diabetes Research and Clinical Practice
Yuan Wang, Jing Dong, Yi Wang, Wei Wei, Binbin Song, Zhongyan Shan, Weiping Teng, Jie Chen
Iodine is a significant micronutrient. Iodine deficiency (ID)-induced hypothyroxinemia and hypothyroidism during developmental period can cause cerebellar dysfunction. However, mechanisms are still unclear. Therefore, the present research aims to study effects of developmental hypothyroxinemia caused by mild ID and hypothyroidism caused by severe ID or methimazole (MMZ) on parallel fiber-Purkinje cell (PF-PC) synapses in filial cerebellum. Maternal hypothyroxinemia and hypothyroidism models were established in Wistar rats using ID diet and deionized water supplemented with different concentrations of potassium iodide or MMZ water...
October 2016: Biological Trace Element Research
Hui Min, Yi Wang, Jing Dong, Yuan Wang, Ye Yu, Zhongyan Shan, Qi Xi, Weiping Teng, Jie Chen
Although the salt iodization programmes are taken to control iodine deficiency (ID), some regions are still suffering from marginal ID. During pregnancy, marginal ID frequently leads to subtle insufficiency of thyroid hormones, characterized as low serum T4 levels. Therefore, the present research was to explore the effects of maternal marginal ID exposure on dendritic arbor growth in the hippocampal CA1 region and the underlying mechanisms. We established Wistar rat models with ID diet during pregnancy and lactation...
June 2016: Neuromolecular Medicine
Xuhong Hou, Jieyuzhen Qiu, Peizhu Chen, Jun Lu, Xiaojing Ma, Juming Lu, Jianping Weng, Linong Ji, Zhongyan Shan, Jie Liu, Haoming Tian, Qiuhe Ji, Dalong Zhu, Jiapu Ge, Lixiang Lin, Li Chen, Xiaohui Guo, Zhigang Zhao, Qiang Li, Zhiguang Zhou, Wenying Yang, Weiping Jia
Different studies have produced conflicting results regarding the association between smoking and diabetes mellitus, and detailed analysis of this issue in Chinese males based on nationwide samples is lacking. We explored the association between cigarette smoking and newly-diagnosed diabetes mellitus (NDM) in Chinese males using a population-based case-control analysis; 16,286 male participants without previously diagnosed diabetes were included. Prediabetes and NDM were diagnosed using the oral glucose tolerance test...
2016: PloS One
Xin Liu, Jinyuan Mao, Cheng Han, Shiqiao Peng, Chenyan Li, Ting Jin, Chenling Fan, Zhongyan Shan, Weiping Teng
CXC chemokine ligand 12 (CXCL12) and its receptor, CXC chemokine receptor 4 (CXCR4), are upregulated in mice with autoimmune thyroid diseases. However, whether this interaction is involved in the pathophysiology of autoimmune thyroiditis (AIT) remains to be elucidated. In the present study, the effects of the CXCR4 antagonist, AMD3100, in an iodine‑induced autoimmune thyroiditis model were investigated. NOD.H‑2h4 mice were randomly separated into a control, AIT and AIT+AMD3100 groups. The mice were fed with 0...
April 2016: Molecular Medicine Reports
Chenyan Li, Shiqiao Peng, Xiaomei Zhang, Xiaochen Xie, Danyang Wang, Jinyuan Mao, Xiaochun Teng, Zhongyan Shan, Weiping Teng
CONTEXT: Iodine nutrition is a global event, especially for pregnant women. OBJECTIVE: To develop applicable index of iodine intake for population during pregnancy. DESIGN, SETTING, AND PARTICIPANTS: From 2012 to 2014, pregnant women at less than 8 weeks of gestation (n = 222) and reproductive-age women (n = 827) participated in this study. The pregnant women were evaluated at follow-up visits at 8, 12, 16, 20, 28, and 36 weeks of gestation and 3 and 6 months postpartum...
March 2016: Journal of Clinical Endocrinology and Metabolism
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