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https://www.readbyqxmd.com/read/28812866/directly-coating-multifunctional-interlayer-on-the-cathode-via-electrospinning-for-advanced-lithium-sulfur-batteries
#1
Yueying Peng, Yiyong Zhang, Yunhui Wang, Xiu Shen, Feng Wang, He Li, Bing-Joe Hwang, Jinbao Zhao
Lithium sulfur battery is considered as a prospective candidate for high-energy-storage system as its high theoretical specific capacity and energy. However, the dissolution and shutter of polysulfides lead to low active material utilization and fast capacity fading. Electrospinning technology is employed to directly coat an interlayer composed of polyacrylonitrile (PAN) and nitrogen-doped carbon black (NC) fibers on the cathode. Benefited from electrospinning technology, the PAN-NC fibers possess good electrolyte infiltration for fast lithium-ion transport and great flexibility for adhering on the cathode...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812748/cyclometalated-iridium-iii-n-heterocyclic-carbene-complexes-as-potential-mitochondrial-anticancer-and-photodynamic-agents
#2
Yi Li, Bing Liu, Xin-Ran Lu, Meng-Feng Li, Liang-Nian Ji, Zong-Wan Mao
Metal N-heterocyclic carbene (NHC) complexes represent a promising class of anticancer therapeutic agents. In this work, four cyclometalated iridium(iii) complexes (Ir1-Ir4) containing N-heterocyclic carbene ligands have been explored as mitochondrial anticancer and photodynamic agents. These complexes are more cytotoxic than cisplatin against the cancer cells screened, can quickly penetrate into A549 cells and are mainly localized in the mitochondria. Mechanism studies show that these complexes exert their anticancer efficacy by increasing the intracellular ROS level, reducing the mitochondrial membrane potential (MMP) and inducing apoptosis...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28812210/increased-il-6-expression-on-thp-1-by-il-34-stimulation-up-regulated-rheumatoid-arthritis-th17-cells
#3
Bing Wang, Yawei Tang, Xiaotong Sun, Xunli Ouyang, Han Li, Jing Wei, Yan Zhang, Xia Li
IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4(+)T cells coculture system. CD4(+)T cells were purified from RA PBMC using immunomagnetic beads. THP-1 were cultured with RA CD4(+)T cells. The frequency of Th17 cells was determined by FACS. Fluorscence indensity and expression of ROS were detected by FACS and cell staining, respectively...
August 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28811978/development-and-characterization-of-naive-single-type-tumor-antigen-specific-cd8-t-lymphocytes-from-murine-pluripotent-stem-cells
#4
Fengyang Lei, Mohammad Haque, Praneet Sandhu, Swetha Ravi, Jianyong Song, Bing Ni, Songguo Zheng, Deyu Fang, Hongyan Jia, Jin-Ming Yang, Jianxun Song
Optimal approaches to differentiate tumor antigen-specific cytotoxic T lymphocytes (CTLs) from pluripotent stem cells (PSCs) remain elusive. In the current study, we showed that combination of in vitro priming through Notch ligands and in vivo development facilitated the generation of tumor Ag-specific CTLs that effectively inhibited tumor growth. We co-cultured the murine induced PSCs (iPSCs) genetically modified with tyrosinase-related protein 2 (TRP2)-specific T cell receptors with OP9 cell line expressing both Notch ligands Delta-like 1 and 4 (OP9-DL1/DL4) for a week before adoptively transferred into recipient C67BL/6 mice...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811626/outbreak-and-genotyping-of-canine-distemper-virus-in-captive-siberian-tigers-and-red-pandas
#5
He Zhang, Fen Shan, Xia Zhou, Bing Li, Jun-Qiong Zhai, Shu-Zhan Zou, Meng-Fan Wu, Wu Chen, Shao-Lun Zhai, Man-Lin Luo
In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811591/alteration-of-sheep-coat-color-pattern-by-disruption-of-asip-gene-via-crispr-cas9
#6
Xuemei Zhang, Wenrong Li, Chenxi Liu, Xinrong Peng, Jiapeng Lin, Sangang He, Xuejiao Li, Bing Han, Ning Zhang, Yangsheng Wu, Lei Chen, Liqin Wang, MaYila, Juncheng Huang, Mingjun Liu
Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of seven indels were identified in 5 of 6 born lambs. Each targeted lamb happened at least two kinds of modifications, and targeted lambs with multiple modifications displayed variety of coat color patterns. Three lambs with 4 bp deletion showed badgerface with black body coat color in two lambs, and brown coat color with light ventral pigmentation in another one...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811472/the-universal-existence-of-myodural-bridge-in-mammals-an-indication-of-a-necessary-function
#7
Nan Zheng, Xiao-Ying Yuan, Yan-Yan Chi, Pei Liu, Bing Wang, Jia-Ying Sui, Seung-Ho Han, Sheng-Bo Yu, Hong-Jin Sui
The "myodural bridge" was described in literatures as a dense fibrous tissue connecting the sub-occipital musculature with the spinal dura mater in human studies. Now the concept of "myodural bridge" was perceived as an exact anatomical structure presumably essential for critical physiological functions in human body, and might exist in other mammals as well. To determine the existence of the "myodural bridge" in other mammals and to lay a foundation for the functional study, we examined representatives in five different mammalian orders...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811375/temperature-increase-reduces-global-yields-of-major-crops-in-four-independent-estimates
#8
Chuang Zhao, Bing Liu, Shilong Piao, Xuhui Wang, David B Lobell, Yao Huang, Mengtian Huang, Yitong Yao, Simona Bassu, Philippe Ciais, Jean-Louis Durand, Joshua Elliott, Frank Ewert, Ivan A Janssens, Tao Li, Erda Lin, Qiang Liu, Pierre Martre, Christoph Müller, Shushi Peng, Josep Peñuelas, Alex C Ruane, Daniel Wallach, Tao Wang, Donghai Wu, Zhuo Liu, Yan Zhu, Zaichun Zhu, Senthold Asseng
Wheat, rice, maize, and soybean provide two-thirds of human caloric intake. Assessing the impact of global temperature increase on production of these crops is therefore critical to maintaining global food supply, but different studies have yielded different results. Here, we investigated the impacts of temperature on yields of the four crops by compiling extensive published results from four analytical methods: global grid-based and local point-based models, statistical regressions, and field-warming experiments...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28811165/dicyanomethylene-substituted-benzothiazole-squaraines-the-efficiency-of-photodynamic-therapy-in-vitro-and-in-vivo
#9
Yongbiao Wei, Xiaoxiao Hu, Luyao Shen, Bing Jin, Xiangjun Liu, Weihong Tan, Dihua Shangguan
The lack of ideal photosensitizers limits the clinicalapplication of photodynamic therapy (PDT). Here we report the PDT efficiency of dicyanomethylene substituted benzothiazole squaraine derivatives. This class of squaraine derivatives possess strong absorption and long excitation and emission wavelengths (ex/em, 685/720nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in the apoptosis and necrosis of cells (phototoxicity). Changing the side chains of these compounds greatly influences their albumin-binding rate, cellular uptake and their phototoxicity...
August 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28811005/regulatory-effects-of-mir-146a-b-on-the-function-of-endothelial-progenitor-cells-in-acute-ischemic-stroke-in-mice
#10
Zeng-Feng Su, Zhong-Wu Sun, Ying Zhang, Shu Wang, Qi-Gui Yu, Ze-Bing Wu
The study aims to explore how microRNA-146a/b (miR-146a/b) regulates the function of endothelial progenitor cells (EPCs) in acute ischemic stroke in mice. Eighty male SPF C57BL/6J mice were evenly divided into the model-6 h, model-12 h, model-24 h (mice suffered from middle cerebral artery occlusion [MCAO] for 6 h, 12 h and model-24 h) and normal groups. EPCs were transfected and assigned into the control, MCAO, MCAO-miR-146a, MCAO-miR-146b and MCAO-miR-146a/b groups. The qRT-PCR was used to detect miR-146a/b expression in EPCs...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28810819/low-cll-1-expression-is-a-novel-adverse-predictor-in-123-patients-with-de-novo-cd34-acute-myeloid-leukemia
#11
Jin Wang, Yanyu Wang, Wen-Lian Chen, Jie Hao, Zhanyun Liu, Xiangqin Weng, Yan Sheng, Jing Wu, Yongmei Zhu, Bing Chen, Shu-Min Xiong, Yu Chen, Qiusheng Chen, Hui-Ping Sun, Junmin Li
Recent reports state that C-type lectin-like molecule-1 (CLL-1) in acute myeloid leukemia (AML) is expressed primarily on myeloid cells, but there is still no investigation about its prognostic significance on leukemic blast compartment. Hence, this study aimed to evaluate the prognostic value of CLL-1 in 123 patients with de novo CD34+ non-M3 AML. Multiparameter flow cytometry was used to assess the expression of CLL-1 on immature compartment in AML and control groups. We found that CLL-1 expression level on blast compartment was closely linked to clinical characteristics, treatment response and survival outcome of patients...
August 16, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28810743/layer-by-layer-molecular-assemblies-for-dye-sensitized-pho-toelectrosynthesis-cells-prepared-by-atomic-layer-deposi-tion
#12
Degao Wang, Matthew V Sheridan, Bing Shan, Byron H Farnum, Seth L Marquard, Benjamin D Sherman, Michael S Eberhart, Animesh Nayak, Christopher Dares, Atanu Das, R Morris Bullock, Thomas J Meyer
In a Dye Sensitized Photoelectrosynthesis Cell (DSPEC) the relative orientation of the catalyst and chromophore plays an important role in determining the device efficiency. Here we introduce a new, robust atomic layer deposition (ALD) procedure for the preparation of molecular chromophore-catalyst assemblies on wide bandgap semiconductors. In this procedure, solution deposited, phosphonate derivatized metal complexes on metal oxide surfaces are treated with reactive metal reagents in the gas phase by ALD to form an outer metal ion bridging group which can bind a second phosphonate containing species from solution to establish a R1-PO2-O-M-O-PO2-R2 type surface assembly...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28810646/sex-comb-on-midleg-like-2-is-a-novel-specific-marker-for-the-diagnosis-of-gastroenteropancreatic-neuroendocrine-tumors
#13
Jiao-Jiao Yang, Hua Huang, Ming-Bing Xiao, Feng Jiang, Wen-Kai Ni, Yi-Fei Ji, Cui-Hua Lu, Run-Zhou Ni
Sex comb on midleg like-2 (SCML2) is a polycomb-group protein that encodes transcriptional repressors essential for appropriate development in the fly and in mammals. On the basis of previous findings, the present study aimed to explore the possibility of developing SCML2 into a new diagnostic marker for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A total of 64 paired GEP-NET tissues and adjacent non-tumorous tissues were obtained from patients who had undergone surgical resection between January 2009 and January 2014, and the expression of SCML2 and two neuroendocrine markers, namely synaptophysin (Syn) and chromogranin A (CgA), in the tissues was assessed by immunohistochemistry...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810635/curcumin-protects-against-acute-renal-injury-by-suppressing-jak2-stat3-pathway-in-severe-acute-pancreatitis-in-rats
#14
Shuaijun Zhu, Chi Zhang, Qinyong Weng, Bing Ye
The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured. Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured using ELISA kits...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810467/binge-eating-and-binge-drinking-among-adolescents-the-role-of-drinking-and-eating-motives
#15
Sara Pompili, Fiorenzo Laghi
This study aimed to investigate the motivations underlying binge eating and binge drinking in a sample of 302 adolescents. Our findings showed that binge eating was significantly correlated with gender, environmental, emotional, and social eating. Hierarchical multiple regression analysis indicated that emotional and environmental eating were significant positive predictors of binge eating, whereas binge drinking was significantly correlated with enhancement, social, and coping motives. Only enhancement motives were significant predictors of binge drinking...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810348/-a-preliminary-discussion-on-the-contents-and-value-of-all-diseases-1-the-medical-bamboo-slips-unearthed-from-han-tomb-in-laoguanshan-of-chengdu
#16
Y Ye, Q Zhang, Y L Ren, J M Li
Among the medical bamboo slips unearthed from Han tomb in Laoguanshan of Chengdu, the Zhu bing (All Diseases) is a monograph to discuss the characteristics of signs and symptoms. Based on the differences of writing styles, diseases involved, expounding methods and writing rules, the book is divided, by the research team, into 2 parts: All Diseases(1) and All Diseases(2). All Diseases(1) includes over 130 slips, 2 000 characters with totally more than 100 disease names, containing multiple clinical disciplines...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28810152/driving-forces-and-impacts-of-food-system-nitrogen-flows-in-china-1990-to-2012
#17
Bing Gao, Yunfeng Huang, Wei Huang, Yalan Shi, Xuemei Bai, Shenghui Cui
Food nitrogen (N), which includes animal-food (AN) and plant-food N (PN), has been driven by population growth (PG), dietary changes associated with income growth (DC) and rural-urban migration (M) over the past three decades, and these changes combined with their N cost, have caused some effect on N use in China's food system. Although there is an increasing literature on food N and its environmental impacts in China, the relative magnitude of these driving forces are not well understood. Here we first quantify the differences in per capita AN and PN consumption in urban and rural areas and their impacts on N input to the food system during 1990-2012, and then quantify the relative contributions of DC, PG and M in the overall N change during this period...
August 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28809846/the-use-of-trace-eyeblink-classical-conditioning-to-assess-hippocampal-dysfunction-in-a-rat-model-of-fetal-alcohol-spectrum-disorders
#18
Tuan D Tran, Aenia Amin, Keith G Jones, Ellen M Sheffer, Lidia Ortega, Keith Dolman
Neonatal rats were administered a relatively high concentration of ethyl alcohol (11.9% v/v) during postnatal days 4-9, a time when the fetal brain undergoes rapid organizational change and is similar to accelerated brain changes that occur during the third trimester in humans. This model of fetal alcohol spectrum disorders (FASDs) produces severe brain damage, mimicking the amount and pattern of binge-drinking that occurs in some pregnant alcoholic mothers. We describe the use of trace eyeblink classical conditioning (ECC), a higher-order variant of associative learning, to assess long-term hippocampal dysfunction that is typically seen in alcohol-exposed adult offspring...
August 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28809769/adverse-experiences-in-childhood-and-sexually-transmitted-infection-risk-from-adolescence-into-adulthood
#19
Stephanie London, Kelly Quinn, Joy D Scheidell, B Christopher Frueh, Maria R Khan
BACKGROUND: Childhood maltreatment, particularly sexual abuse, has been found to be associated with sexual risk behaviors later in life. We aimed to evaluate associations between a broad range of childhood traumas and sexual risk behaviors from adolescence into adulthood. METHODS: Using data from Waves I, III and IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health), we used logistic regression to estimate the unadjusted odds ratio (OR) and adjusted OR (AOR) for associations between 9 childhood traumas and a cumulative trauma score and three sexual risk outcomes (multiple partnerships, sex trade involvement, and sexually transmitted infection [STI]) in adolescence, young adulthood, and adulthood...
September 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28809564/a-chemoselective-n-arylation-reaction-of-2-aminopyridine-derivatives-with-arynes
#20
Bin Cheng, Jian Wei, Bing Zu, Jianfei Zhao, Taimin Wang, Xiaoguang Duan, Renqi Wang, Yun Li, Hongbin Zhai
A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as well as pyrido [1,2-a]benzimidazoles.
August 15, 2017: Journal of Organic Chemistry
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