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https://www.readbyqxmd.com/read/29775997/improved-acmg-compliant-in-silico-prediction-of-pathogenicity-for-missense-substitutions-encoded-by-tp53-variants
#1
Cristina Fortuno, Paul A James, Erin L Young, Bing Feng, Magali Olivier, Tina Pesaran, Sean V Tavtigian, Amanda B Spurdle
Clinical interpretation of germline missense variants represents a major challenge, including those in the TP53 Li-Fraumeni syndrome gene. Bioinformatic prediction is a key part of variant classification strategies. We aimed to optimize the performance of the Align-GVGD tool used for p53 missense variant prediction, and compare its performance to other bioinformatic tools (SIFT, PolyPhen-2) and ensemble methods (REVEL, BayesDel). Reference sets of assumed pathogenic and assumed benign variants were defined using functional and/or clinical data...
May 18, 2018: Human Mutation
https://www.readbyqxmd.com/read/29775952/molecular-simulation-and-experimental-validation-of-resorcinol-adsorption-on-ordered-mesoporous-carbon-omc
#2
Zaki Uddin Ahmad, Bing Chao, Mas Iwan Konggidinata, Qiyu Lian, Mark E Zappi, Daniel Dianchen Gang
Numerous research works have been devoted in the adsorption area using experimental approaches. All these approaches are based on trial and error process and extremely time consuming. Molecular simulation technique is a new tool that can be used to design and predict the performance of an adsorbent. This research proposed a simulation technique that can greatly reduce the time in designing the adsorbent. In this study, a new Rhombic ordered mesoporous carbon (OMC) model is proposed and constructed with various pore sizes and oxygen contents using Materials Visualizer Module to optimize the structure of OMC for resorcinol adsorption...
April 27, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29775887/gender-and-age-varying-associations-of-sensation-seeking-and-substance-use-across-young-adulthood
#3
Rebecca J Evans-Polce, Megan S Schuler, John E Schulenberg, Megan E Patrick
INTRODUCTION: Sensation seeking is associated with elevated risk for substance use among adolescents and young adults. However, whether these associations vary across age for young men and women is not well characterized. METHODS: Using data from the Monitoring the Future (MTF) panel study, we examine the age-varying associations of sensation seeking and three types of substance use behavior (binge drinking, cigarette use, and marijuana use) across ages 18 to 30 using time-varying effect modeling...
May 4, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29775427/determination-of-fipronil-and-its-metabolites-in-chicken-egg-muscle-and-cake-by-a-modified-quechers-method-coupled-with-lc-ms-ms
#4
Qiaozhen Guo, Shan Zhao, Jing Zhang, Kailun Qi, Zhenxia Du, Bing Shao
An easy-to-use method for determining the levels of fipronil and its metabolites (fipronil-desulfinyl, fipronil-sulfone and fipronil-sulfide) in chicken egg, muscle and cake was developed and validated using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The samples were extracted using acetonitrile, salted out with sodium chloride at -20 °C, and then purified by combined PSA and C18 phases and anhydrous magnesium sulfate...
May 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29775233/dialysis-modality-and-mortality-in-polycystic-kidney-disease
#5
Chenchen Zhou, Yaodong Gu, Changlin Mei, Bing Dai, Yi Wang, Cheng Xue
INTRODUCTION: Identifying the appropriate modality between hemodialysis (HD) and peritoneal dialysis (PD) is an unresolved issue in polycystic kidney disease (PKD) patients. This study aims to illustrate whether the mortality and survival are different among individuals receiving HD comparing PD. METHODS: We searched PubMed, EMBASE, and China National Knowledge Infrastructure about cohort studies involving PKD patients with end stage renal disease and comparing HD with PD...
May 18, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29775230/alcohol-enhances-symptoms-and-propensity-for-infection-in-inflammatory-bowel-disease-patients-and-a-murine-model-of-dss-induced-colitis
#6
Abigail R Cannon, Paulius V Kuprys, Adrienne N Cobb, Xianzhong Ding, Anai N Kothari, Paul C Kuo, Joshua M Eberhardt, Adam M Hammer, Niya L Morris, Xiaoling Li, Mashkoor A Choudhry
Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is "Don't Drink Alcohol" as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD...
May 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29774983/mechanistic-insights-into-the-ni-catalyzed-reductive-carboxylation-of-c-o-bonds-in-aromatic-esters-with-co-2-understanding-remarkable-ligand-and-traceless-directing-group-effects
#7
Yan-Li Han, Bing-Yuan Zhao, Kun-Yao Jiang, Hui-Min Yan, Zhu-Xia Zhang, Wen-Jing Yang, Zhen Guo, Yan-Rong Li
The mechanism of the Ni0 -catalyzed reductive carboxylation reaction of C(sp2 )-O and C(sp3 )-O bonds in aromatic esters with CO2 to access valuable carboxylic acids was comprehensively studied by using DFT calculations. Computational results revealed that this transformation was composed of several key steps: C-O bond cleavage, reductive elimination, and/or CO2 insertion. Of these steps, C-O bond cleavage was found to be rate-determining, and it occurred through either oxidative addition to form a NiII intermediate, or a radical pathway that involved a bimetallic species to generate two NiI species through homolytic dissociation of the C-O bond...
May 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29774326/first-identification-of-unstable-phosphino-formic-acid-h-2-pcooh
#8
Cheng Zhu, Robert Frigge, Andrew M Turner, Ralf I Kaiser, Bing-Jian Sun, Si-Ying Chen, Agnes H H Chang
The hitherto elusive phosphino formic acid molecule (H2PCOOH) was detected for the first time in the gas phase. Theoretical calculations revealed an unexpected kinetic stability of H2PCOOH compared to the isovalent carbamic acid (H2NCOOH) although the replacement of a single nitrogen atom by phosphorus decreases the bond order from a partial double (-C[double bond, length as m-dash]N-) to a single (-C-P-) bond. This work provides a fundamental framework to explore the synthesis and stability of derivatives of carbonic acid (H2CO3), in which one or both hydroxyl groups (OH) are replaced by hydride moieties involving third row atoms...
May 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29773643/the-transcription-factor-bhlhe40-is-a-switch-of-inflammatory-versus-antiinflammatory-th1-cell-fate-determination
#9
Fang Yu, Suveena Sharma, Dragana Jankovic, Rama Krishna Gurram, Pan Su, Gangqing Hu, Rao Li, Sadiye Rieder, Keji Zhao, Bing Sun, Jinfang Zhu
Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)-γ; some Th1 cells can also be antiinflammatory through producing IL-10. However, the molecular switch for regulating the differentiation of inflammatory and antiinflammatory Th1 cells is still elusive. Here, we show that Bhlhe40 -deficient CD4 Th1 cells produced less IFN-γ but substantially more IL-10 than wild-type Th1 cells both in vitro and in vivo...
May 17, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29773555/prostaglandin-f-2%C3%AE-facilitates-hepatic-glucose-production-through-camkii%C3%AE-p38-foxo1-signaling-pathway-in-fasting-and-obesity
#10
Yuanyang Wang, Shuai Yan, Bing Xiao, Shengkai Zuo, Qianqian Zhang, Guilin Chen, Yu Yu, Di Chen, Qian Liu, Yi Liu, Yujun Shen, Ying Yu
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for increased fasting plasma glucose concentrations. Circulating prostaglandin (PG) F2α is also markedly elevated in diabetes mellitus; however, whether and how PGF2α regulates hepatic glucose metabolism remain unknown. Here, we demonstrated that PGF2α receptor (F-prostanoid receptor; FP) was upregulated in livers of mice upon fasting- and diabetic stress. Hepatic deletion of the FP receptor suppressed fasting-induced hepatic gluconeogenesis, whereas FP overexpression enhanced hepatic gluconeogenesis in mice...
May 17, 2018: Diabetes
https://www.readbyqxmd.com/read/29773375/characterization-and-prebiotic-activity-in-vitro-of-inulin-type-fructan-from-codonopsis-pilosula-roots
#11
Yu-Ping Fu, Li-Xia Li, Bing-Zhao Zhang, Berit Smestad Paulsen, Zhong-Qiong Yin, Chao Huang, Bin Feng, Xing-Fu Chen, Ren-Rong Jia, Xu Song, Xue-Qin Ni, Bo Jing, Fa-Ming Wu, Yuan-Feng Zou
The inulin-type fructan was obtained by DEAE anion exchange chromatography from C. pilosula Nannf. var. modesta (Nannf.) L. T. Shen, after optimized extract condition, which was established by response surface methodology, designed using Box-Behnken factorial design and the optimum condition were: extracting 2.5 h with ratio of solvent to material 40 mL/g at 100 °C, twice. The maximum extraction yield was 20.6 ± 0.2%. It was confirmed as β-(2-1) linkage fructan, with terminal glucose, and with a degree of polymerization of 2-17 (DPav  = 6), shown by the results of methanolysis, methylation, nuclear magnetic resonance and molecular weight determination...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772821/a-preliminary-analysis-of-wind-retrieval-based-on-gf-3-wave-mode-data
#12
Lei Wang, Bing Han, Xinzhe Yuan, Bin Lei, Chibiao Ding, Yulin Yao, Qi Chen
This paper presents an analysis of measurements of the normalized radar cross-(NRCS) in Wave Mode for Chinese C-band Gaofen-3(GF-3) synthetic aperture radar (SAR). Based on 2779 images from GF-3 quad-polarization SAR in Wave Mode and collocated wind vectors from ERA-Interim, this experiment verifies the feasibility of using ocean surface wind fields and VV-polarized NRCS to perform normalized calibration. The method uses well-validated empirical C-band geophysical model function (CMOD4) to estimate the calibration constant for each beam...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29772717/a-rapid-screen-for-host-encoded-mirnas-with-inhibitory-effects-against-ebola-virus-using-a-transcription-and-replication-competent-virus-like-particle-system
#13
Zhongyi Wang, Jiaming Li, Yingying Fu, Zongzheng Zhao, Chunmao Zhang, Nan Li, Jingjing Li, Hongliang Cheng, Xiaojun Jin, Bing Lu, Zhendong Guo, Jun Qian, Linna Liu
MicroRNAs (miRNAs) may become efficient antiviral agents against the Ebola virus (EBOV) targeting viral genomic RNAs or transcripts. We previously conducted a genome-wide search for differentially expressed miRNAs during viral replication and transcription. In this study, we established a rapid screen for miRNAs with inhibitory effects against EBOV using a tetracistronic transcription- and replication-competent virus-like particle (trVLP) system. This system uses a minigenome comprising an EBOV leader region, luciferase reporter, VP40, GP, VP24, EBOV trailer region, and three noncoding regions from the EBOV genome and can be used to model the life cycle of EBOV under biosafety level (BSL) 2 conditions...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772340/effects-of-temperature-and-solvent-condition-on-phase-separation-induced-molecular-fractionation-of-gum-arabic-hyaluronan-aqueous-mixtures
#14
Bing Hu, Lingyu Han, Zhiming Gao, Ke Zhang, Saphwan Al-Assaf, Katsuyoshi Nishinari, Glyn O Phillips, Jixin Yang, Yapeng Fang
Effects of temperature and solvent condition on phase separation-induced molecular fractionation of gum arabic/hyaluronan (GA/HA) mixed solutions were investigated. Two gum arabic samples (EM10 and STD) with different molecular weights and polydispersity indices were used. Phase diagrams, including cloud and binodal curves, were established by visual observation and GPC-RI methods. The molecular parameters of control and fractionated GA, from upper and bottom phases, were measured by GPC-MALLS. Fractionation of GA increased the content of arabinogalactan-protein complex (AGP) from ca...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29771611/firearm-ownership-storage-practices-and-suicide-risk-factors-in-washington-state-2013-2016
#15
Erin Renee Morgan, Anthony Gomez, Ali Rowhani-Rahbar
OBJECTIVES: To characterize firearm ownership and storage practices in Washington State and assess their relationship with suicide risk factors. METHODS: Using Washington State Behavioral Risk Factor Surveillance System data for 2013 to 2016, we conducted survey-weighted multivariable Poisson regression models to obtain prevalence ratios (PRs) and confidence intervals (CIs). RESULTS: Of 34 884 adult respondents, 34.3% (95% CI = 33.7%, 35...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29770690/fluorinated-dna-micelles-synthesis-and-properties
#16
Jianmei Zou, Cheng Jin, Ruowen Wang, Hailan Kuai, Lili Zhang, Xiao-Bing Zhang, Juan Li, Liping Qui, Weihong Tan
Creating new functional building blocks that expand the versatility of nanostructures depends on bottom-up self-assembly of amphiphilic biomolecules. Inspired by the unique physicochemical properties of hydrophobic perfluorocarbons, coupled with the powerful functions of nucleic acids, we herein report the synthesis of a series of diperfluorodecyl-DNA conjugates (PF-DNA) which can efficiently self-assemble into micelles in aqueous solution. Based on the micelle structure, both target binding affinity and enzymatic resistance of the DNA probe can be enhanced...
May 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29770666/-molluscicidal-effect-and-mechanism-of-action-of-niclosamidate-against-oncomelania-hupensis
#17
Luo Bing-Rong, Yao Jun-Min, Wang Wei-Si, Li Shi-Zhu, Yang Jing, Chen Shao-Rong, Luo Jia-Jun, Liu Yu-Hua, Duan Li-Ping
OBJECTIVE: To evaluate the molluscicidal effect of niclosamidate against Oncomelania hupensis in laboratory and explore its mechanism by determining the enzyme activities of six important enzymes in snail soft tissues. METHODS: O. hupensis snails were treated with niclosamidate at the concentration of 1.25 mg/L for 24 h and the snail soft tissues were separated and prepared for analysis. The enzyme activities of NOS, AChE, SDH, LDH, ACP and AKP were determined by ultraviolet spectrophotometry...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29770662/-construction-and-expression-of-multi-gene-recombinant-plasmid-peg-fp-n1-hbsag-rop2
#18
Ma Rong, Xiao Ting, Li Jin, Sun Hui, Xu Chao, Huang Bing-Cheng, Yin Kun, Zhao Gui-Hua, Cui Yong, Zhu Song, Liu Gong-Zhen, Yan Ge, Wei Qing-Kuan
OBJECTIVE: To construct pEGFP-N1-HBsAg-ROP2 recombinant expression plasmid and transfect HEK293T cells for expression, and pay a way for Toxoplasma gondii nucleic acid vaccine development. METHODS: According to the HBsAg gene sequence and pcDNA3-p30-ROP2 recombinant plasmid restriction sites, the HBsAg gene was amplified by PCR. The HBsAg gene was cloned into the pcDNA3-p30-ROP2 and instead of p30 gene. The HBsAg-ROP2 fragment was amplified by PCR and digested with Hind Ⅲ and Kpn Ⅰ to clone into the pEGFP-N1 eukaryotic expression vector and construct the recombinant pEGFP-N1-HBsAg-ROP2...
March 14, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29770518/long-life-and-high-power-binder-free-cathode-based-on-one-step-synthesis-of-radical-polymers-with-multi-pendant-groups
#19
Yaoguang Chen, Yangfan Zhang, Xiu Liu, Xuliang Fan, Bing Bai, Kang Yang, Zhongxin Liang, Zishou Zhang, Kancheng Mai
The main bottlenecks for the widespread application of radical polymers in organic radical batteries are poor cycling stability, due to the dissolution of radical polymers into the electrolyte, and the low efficiency of multi-step synthesis strategies. Herein, a kind of electrolyte-resistant radical polymer bearing multi-pendant groups (poly(ethylene-alt-TEMPO maleate) (PETM)) is designed and synthesized through a one-step esterification reaction to graft 4-hydroxy-2,2,6,6-teramethylpiperidinyl-1-oxy into the commercially available poly(ethylene-alt-maleic anhydride)...
May 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29770394/a-neutral-auxiliary-ligand-enhanced-dysprosium-iii-single-molecule-magnet
#20
Xiao-Xiang Chen, Fang Ma, Mei-Xing Xu, Jin-Cheng Bi, Hao-Ling Sun, Bing-Wu Wang, Song Gao
An approximately equatorial three-coordinated dysprosium(iii) complex DyL2[N(SiMe3)2] (L = bis(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)amine) with an additional neutral auxiliary pyrrole ligand was synthesised and structurally characterized. The magnetic property measurement shows that it is an equatorial charge distributed field-induced single-molecule magnet. Ab initio calculations reveal that the neutral pyrrole ligand plays an important role in stabilizing the ground doublet and thus enhancing the magnetic anisotropy...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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