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https://www.readbyqxmd.com/read/27933509/effect-of-shuanghu-qinggan-granule-and-yigan-yiqi-jieyu-granule-plus-lamivudine-on-chronic-hepatitis-b-patients-a-randomized-double-blind-placebo-controlled-trial
#1
Yong-An Ye, De-Lu Tian, Jian Jiang, Jun Li, Jian-Jie Chen, Zhi-Hong Li, Wei-Guo Ma, Yi-Ming Zhao, Rong-Bing Wang, Shi-Zhong Yang, Feng-Zhen Shao, Guang Ji, Da-Qiao Zhou, Tie-Jun Liu, Dong-Sheng Cheng, Wei Zhang, Ke-Wei Sun, Yu-Fen Wang, Le-Quan Min, Xiao-Ke Li
OBJECTIVE: To observe the clinical efficacy and safety of Shuanghu Qinggan Granule ( , SQG) plus Yigan Yiqi Jieyu Granule (, YYJG) combined with lamivudine (LAM) on chronic hepatitis B (CHB) patients. METHODS: The study was a multicenter, randomized, double-blinded and parallel controlled trial. A total of 320 patients were randomly allocated into 2 groups equally: 160 patients (treatment group) were given SQG and YYJG combined with LAM; and 160 patients (control group) were given LAM plus Chinese herb placebo, respectively...
December 8, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27933036/functional-analysis-of-the-nitrogen-metabolite-repression-regulator-gene-nmra-in-aspergillus-flavus
#2
Xiaoyun Han, Mengguang Qiu, Bin Wang, Wen-Bing Yin, Xinyi Nie, Qiuping Qin, Silin Ren, Kunlong Yang, Feng Zhang, Zhenhong Zhuang, Shihua Wang
In Aspergillus nidulans, the nitrogen metabolite repression (NMR) regulator NmrA plays a major role in regulating the activity of the GATA transcription factor AreA during nitrogen metabolism. However, the function of nmrA in A. flavus has not been previously studied. Here, we report the identification and functional analysis of nmrA in A. flavus. Our work showed that the amino acid sequences of NmrA are highly conserved among Aspergillus species and that A. flavus NmrA protein contains a canonical Rossmann fold motif...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27932876/effectiveness-of-neuromuscular-electrical-stimulation-for-the-rehabilitation-of-moderate-to-severe-copd-a-meta-analysis
#3
Rong-Chang Chen, Xiao-Ying Li, Li-Li Guan, Bing-Peng Guo, Wei-Liang Wu, Zi-Qing Zhou, Ya-Ting Huo, Xin Chen, Lu-Qian Zhou
PURPOSE: Patients with COPD often experience skeletal muscle dysfunction. For those who are unable or unwilling to undertake physical training, neuromuscular electrical stimulation (NMES) may provide an alternative method of rehabilitation. The purpose of this meta-analysis was to investigate the controversial topic of whether this therapy is effective in patients with moderate-to-severe COPD. PATIENTS AND METHODS: We pooled data from nine trials published between January 9, 2002 and January 4, 2016 across PubMed, Embase, Cochrane Central Register of Controlled Trials, Google Scholar, and relevant websites for randomized controlled trials...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27932865/statistical-modeling-methods-to-analyze-the-impacts-of-multiunit-process-variability-on-critical-quality-attributes-of-chinese-herbal-medicine-tablets
#4
Fei Sun, Bing Xu, Yi Zhang, Shengyun Dai, Chan Yang, Xianglong Cui, Xinyuan Shi, Yanjiang Qiao
The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS) immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs), influences of both the manipulated process parameters introduced by an orthogonal experiment design and the intermediate granules' properties on the CQAs were fully investigated by different chemometric methods, such as the partial least squares, the orthogonal projection to latent structures, and the multiblock partial least squares (MBPLS)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932524/partial-tonsillectomy-content-and-readability-of-online-health-information
#5
Kevin Wong, Jessica R Levi
OBJECTIVES: Evaluate the content and readability of health information regarding partial tonsillectomy. METHODS: A web search was performed using the term partial tonsillectomy in Google, Yahoo!, and Bing. The first 50 websites from each search were evaluated using HONcode standards for quality and content. Readability was assessed using the Flesch-Kincaid Grade Level (FKGL), Flesch Reading Ease, Gunning-Fog Index, Coleman-Liau Index, Automated Readability Index, and SMOG score...
December 7, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27932309/binge-alcohol-alters-exercise-driven-neuroplasticity
#6
Emily A Barton, Yanbin Lu, Murad Megjhani, Mark E Maynard, Prathamesh M Kulkarni, Badrinath Roysam, J Leigh Leasure
Exercise is increasingly being used as a treatment for alcohol use disorders (AUD), but the interactive effects of alcohol and exercise on the brain remain largely unexplored. Alcohol damages the brain, in part by altering glial functioning. In contrast, exercise promotes glial health and plasticity. In the present study, we investigated whether binge alcohol would attenuate the effects of subsequent exercise on glia. We focused on the medial prefrontal cortex (mPFC), an alcohol-vulnerable region that also undergoes neuroplastic changes in response to exercise...
December 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27931615/alcohol-and-atrial-fibrillation-a-sobering-review
#7
REVIEW
Aleksandr Voskoboinik, Sandeep Prabhu, Liang-Han Ling, Jonathan M Kalman, Peter M Kistler
Alcohol is popular in Western culture, supported by a perception that modest intake is cardioprotective. However, excessive drinking has detrimental implications for cardiovascular disease. Atrial fibrillation (AF) following an alcohol binge or the "holiday heart syndrome" is well characterized. However, more modest levels of alcohol intake on a regular basis may also increase the risk of AF. The pathophysiological mechanisms responsible for the relationship between alcohol and AF may include direct toxicity and alcohol's contribution to obesity, sleep-disordered breathing, and hypertension...
December 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27931287/ttf1-nps-induce-ers-mediated-apoptosis-and-inhibit-human-hepatoma-cell-growth-in-vitro-and-in-vivo
#8
Bin Xiao, Chao Liu, Bing-Tong Liu, Xuan Zhang, Rong-Rong Liu, Xue-Wu Zhang
Previous studies have shown that 5,2,4-trihydroxy-6,7,5-trimethoxyflavone (TTF1) is the primary anticancer constituent of the traditional Chinese medicinal plant Sorbaria sorbifolia (SS), which has been applied to treat cancer in China. In this study, we investigated the in vitro and in vivo antitumor effects and biological mechanisms of small-molecule TTF1 nanoparticles (TTF1-NPs). The effects of TTF1-NPs on cell growth and apoptosis were investigated using human hepatoma cells. The molecular changes associated with the effects of TTF1-NPs were analyzed by immunocytochemistry and Western blot analysis...
May 2016: Oncology Research
https://www.readbyqxmd.com/read/27930953/adolescent-binge-alcohol-exposure-increases-risk-assessment-behaviors-in-male-wistar-rats-after-exposure-to-an-acute-psychological-stressor-in-adulthood
#9
Audrey Torcaso, AnnaDorothea Asimes, Margaret Meagher, Toni R Pak
Teenage binge drinking is a common practice that has been shown to increase the risk for developing mood disorders in adulthood. The hypothalamo-pituitary-adrenal (HPA) axis is often dysfunctional in mood disorder patients, and animal models of adolescent binge alcohol exposure similarly show disordered HPA axis function, even after long periods of alcohol abstinence. Here, we sought to investigate the anxiety-like behavioral consequences of binge alcohol exposure in a Wistar rat model. Male rats were administered alcohol in a binge pattern during peri-puberty, and one month later, anxiety-like behaviors were measured using the elevated plus maze...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27930952/prevalence-and-psychosocial-correlates-of-food-addiction-in-persons-with-obesity-seeking-weight-reduction
#10
Ariana M Chao, Jena A Shaw, Rebecca L Pearl, Naji Alamuddin, Christina M Hopkins, Zayna M Bakizada, Robert I Berkowitz, Thomas A Wadden
INTRODUCTION: Food addiction is a controversial concept. The potential influence of food addiction on patients' psychosocial functioning and well-being has not been well established. The purpose of this study was to examine the relationships between psychosocial functioning (depressive symptoms and health-related quality of life [HRQOL]) and food addiction as measured by the Yale Food Addiction Scale (YFAS). We also explored whether food addiction contributed additional variance in explaining psychosocial functioning, beyond demographic and clinical factors (e...
November 23, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27930738/mir-151-3p-targets-twist1-to-repress-migration-of-human-breast-cancer-cells
#11
Ting-Chih Yeh, Tzu-Ting Huang, Tien-Shun Yeh, Yu-Ren Chen, Kai-Wen Hsu, Pen-Hui Yin, Hsin-Chen Lee, Ling-Ming Tseng
TWIST1 is a highly conserved basic helix-loop-helix transcription factor that contributes to cancer metastasis by promoting an epithelial-mesenchymal transition and repressing E-cadherin gene expression in breast cancer. In this study, we explored the potential role of miR-151 in TWIST1 expression and cancer properties in human breast cancer cells. We found that the human TWIST1 3'UTR contains a potential binging site for miR-151-3p at the putative target sequence 5'-CAGUCUAG-3'. Using a TWIST1-3'UTR luciferase reporter assay, we demonstrated that the target sequence within the TWIST1 3'UTR is required for miR-151-3p regulation of TWIST1 expression...
2016: PloS One
https://www.readbyqxmd.com/read/27930570/successful-treatment-of-a-rare-extended-retroperitoneal-necrotizing-soft-tissue-infection-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli-a-case-report
#12
Rui He, Xin Qi, Bing Wen, XiangYan Li, Li Guo
RATIONALE: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli). PATIENT CONCERNS: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day. DIAGNOSES: He was admitted with an initial diagnosis of cellulitis...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930557/application-of-array-comparative-genomic-hybridization-in-tetralogy-of-fallot
#13
Lin Liu, Hong-Dan Wang, Cun-Ying Cui, Dong Wu, Tao Li, Tai-Bing Fan, Bang-Tian Peng, Lian-Zhong Zhang, Cheng-Zeng Wang
To explore the underlying pathogenesis and provide references for genetic counseling and prenatal gene diagnosis, we analyzed the chromosome karyotypes and genome-wide copy number variations (CNVs) in 86 patients with tetralogy of Fallot (TOF) by G-banding karyotype analysis and array-comparative genomic hybridization (aCGH), respectively. And then quantitative polymerase chain reaction was used to validate these candidate CNVs. Based on their different properties, CNVs were categorized into benign CNVs, suspiciously pathogenic CNVs, and indefinite CNVs...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930549/prognostic-value-of-the-lymphocyte-monocyte-ratio-in-patients-with-colorectal-cancer-a-meta-analysis
#14
Wei Song, Kai Wang, Run-Jin Zhang, Shu-Bing Zou
BACKGROUND: Inflammation plays a critical role in the pathogenesis and progression of cancer. A low lymphocyte-to-monocyte ratio (LMR) is reported be a poor prognostic factor in multiple malignancies. We performed a meta-analysis to evaluate the prognostic role of preoperative LMR in colorectal cancer (CRC). METHODS: Studies investigating the prognostic role of preoperative LMR on survival in patients with CRC were systematically searched for in MEDLINE, EMBASE, Cochrane databases from inception up to August 2016...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930527/feasibility-of-radiofrequency-ablation-as-an-alternative-to-surgical-intervention-in-patients-with-huge-multiloculated-pyogenic-liver-abscesses-a-retrospective-cohort-study
#15
Shan Ke, Xue-Mei Ding, Jun Gao, Shao-Hong Wang, Jian Kong, Li Xu, Wen-Bing Sun
This retrospective cohort study investigated the feasibility of radiofrequency (RF) ablation as an alternative to surgical intervention in patients with huge multiloculated pyogenic liver abscesses (PLAs).From August 2010 to April 2016, 83 patients with PLA were admitted to Beijing Chao-Yang Hospital, China. Four of these patients had huge multiloculated PLAs and underwent RF ablation plus antibiotics. The inclusion criteria for RF ablation were as follows: multiloculated PLA confirmed by computed tomography (CT) or magnetic resonance imaging (MRI), widest diameter of the PLA ≥5 cm, failure to respond to or not suitable to treatment with percutaneous drainage (PD), and patient refusal of surgery...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929143/effect-of-unplanned-therapy-on-the-prognosis-of-patients-with-extremity-osteosarcoma
#16
Bing Wang, Ming Xu, Kai Zheng, Xiuchun Yu
Unplanned therapy for extremity osteosarcoma can result in erroneous surgical procedures and lack of neoadjuvant chemotherapy before the first operation. Our aim was to compare the prognosis between patients with extremity osteosarcoma who received unplanned therapy and those who received standard treatment. This was a retrospective review of patients with extremity osteosarcoma who received appropriate surgical treatment and neoadjuvant chemotherapy (n = 79) and those who received unplanned therapy (n = 24) between June 2000 and October 2014...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929047/caveolin-1-is-an-aggresome-inducing-protein
#17
Ajit Tiwari, Courtney A Copeland, Bing Han, Caroline A Hanson, Krishnan Raghunathan, Anne K Kenworthy
Caveolin-1 (Cav1) drives the formation of flask-shaped membrane invaginations known as caveolae that participate in signaling, clathrin-independent endocytosis and mechanotransduction. Overexpression or mutations of Cav1 can lead to its mistrafficking, including its accumulation in a perinuclear compartment previously identified as the Golgi complex. Here, we show that in the case of overexpressed Cav1-GFP, this perinuclear compartment consists of cytoplasmic inclusion bodies generated in response to the accumulation of aggregates of misfolded proteins, known as aggresomes...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928853/early-response-to-treatment-in-eating-disorders-a-systematic-review-and-a-diagnostic-test-accuracy-meta-analysis
#18
REVIEW
Bruno Palazzo Nazar, Louise Kathrine Gregor, Gaia Albano, Angelo Marchica, Gianluca Lo Coco, Valentina Cardi, Janet Treasure
OBJECTIVE: Early response to eating disorders treatment is thought to predict a later favourable outcome. A systematic review of the literature and meta-analyses examined the robustness of this concept. METHOD: The criteria used across studies to define early response were summarised following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnostic Test Accuracy methodology was used to estimate the size of the effect. RESULTS: Findings from 24 studies were synthesized and data from 14 studies were included in the meta-analysis...
December 7, 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/27928850/assessment-of-the-diagnostic-value-of-a-urinary-adipsin-rapid-strip-test-for-pre-eclampsia-a-prospective-multicenter-study
#19
Bing Peng, Li Zhang, Jianying Yan, Hongbo Qi, Weiyuan Zhang, Ling Fan, Yayi Hu, Li Lin, Xiaotian Li, Rong Hu, Lan Xie, Jianping Zhang, Yanqiao Wu, Li Li, Rong Zhou
AIM: The purpose of the present study was to evaluate the clinical value of the rapid strip test of urinary adipsin for the quick diagnosis of pre-eclampsia. METHODS: In a multicenter diagnostic test study, we studied the diagnostic accuracy of the rapid strip test of urinary adipsin in women presenting with pre-eclampsia. A total of 204 pre-eclampsia patients and 254 healthy pregnant women were recruited for this study, respectively. The rapid strip test of urinary adipsin was used to detect the adipsin in the urine of each patient...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27928690/from-shoot-to-leaf-step-wise-shifts-in-meristem-and-knox1-activity-correlate-with-the-evolution-of-a-unifoliate-body-plan-in-gesneriaceae
#20
Kanae Nishii, Bing-Hong Huang, Chun-Neng Wang, Michael Möller
Typical dicots possess equal-sized cotyledons and leaf-bearing shoots topped with a shoot apical meristem (SAM), the source of lateral organs, and where KNOX1 homeobox genes act as key regulators. New World Gesneriaceae show typical cotyledons, whereas Old World Gesneriaceae show anisocotyly, the unequal post-germination growth of cotyledons, and include unifoliate (one-leaf) plants. One-leaf plants show an extremely reduced body plan: the adult above-ground photosynthetic tissue consisting of a single cotyledon, a macrocotyledon enlarged by the basal meristem (BM), but lacking a SAM...
December 8, 2016: Development Genes and Evolution
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