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https://www.readbyqxmd.com/read/28931028/the-efficacy-of-extracorporeal-shockwave-lithotripsy-for-symptomatic-ureteral-stones-predictors-of-treatment-failure-without-the-assistance-of-computed-tomography
#1
Bing-Juin Chiang, Chun-Hou Liao, Yu-Hua Lin
OBJECTIVES: Non-contrast computed tomography (NCCT) is not always performed clinically if the diagnosis of ureteral calculi has been confirmed using other radiographic imaging modalities. The aim of this study was to identify predictors of successful extracorporeal shockwave lithotripsy (ESWL) without assistance of NCCT. METHODS: We retrospectively reviewed the medical records of patients with symptomatic solitary ureteral stones who underwent ESWL between November 2015 and January 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28930904/spontaneous-reduction-of-fractured-thoracolumbar-spine-with-complete-dislocation-case-report-with-literature-review
#2
Chen Zhao, Bing Zhang, Jiandang Shi, Yaping Li, Long Pang
Fractures and dislocations with complete lateral displacement of the spine at the lumbar and thoracic levels are some of the most severe types of thoracolumbar trauma. They are usually caused by high-energy trauma and accompanied by extreme, life-threatening injuries and neurological deficits that vary in severity, which may delay operative intervention. It is often difficult to reduce such a complex fracture-dislocation because of the force that the muscles exert on the bone and the injured part of the spinal cord...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28930776/a-phase1b-dose-escalation-study-of-recombinant-circularly-permuted-trail-in-patients-with-relapsed-or-refractory-multiple-myeloma
#3
Jian Hou, Lugui Qiu, Yaozhong Zhao, Xuejun Zhang, Yan Liu, Zhao Wang, Fang Zhou, Yun Leng, Shifang Yang, Hao Xi, Fuxu Wang, Bing Zhu, Wenming Chen, Peng Wei, Xiangjun Zheng
OBJECTIVES: Circularly permuted tumor necrosis factor-related apoptosis-inducing ligand (CPT), or CPT, is a novel antitumor drug candidate. This phase 1b study evaluated the safety, tolerability, pharmacokinetics (PK), and efficacy of single-agent CPT in patients with relapsed or refractory multiple myeloma (RRMM), and aimed to identify the recommended dose for the phase 2 study. MATERIALS AND METHODS: Patients received single or multiple doses (once daily for 5 consecutive days per 21-d cycle) of CPT intravenous infusion at doses of 5, 6...
September 19, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28930290/alcohol-adipose-tissue-and-liver-disease-mechanistic-links-and-clinical-considerations
#4
REVIEW
Richard Parker, Seung-Jin Kim, Bin Gao
Adipose tissue represents a large volume of biologically active tissue that exerts substantial systemic effects in health and disease. Alcohol consumption can profoundly disturb the normal functions of adipose tissue by inducing adipocyte death and altering secretion of adipokines, pro-inflammatory mediators and free fatty acids from adipose tissue, which have important direct and indirect effects on the pathogenesis of alcoholic liver disease (ALD). Cessation of alcohol intake quickly reverses inflammatory changes in adipose tissue, and pharmacological treatment that normalizes adipose tissue function improves experimental ALD...
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28929682/-virtual-screening-for-components-in-chicory-combined-with-cnt2-target-based-on-molecular-docking
#5
Yue Zhou, Bing Zhang, Zhi-Jian Lin, Xiao-Meng Zhang, Fan Li, Hai-Ge Wang, Xue-Jie Wang
To virtual screen the compound of Chicory combined with the concentrative nucleoside transporter 2 (CNT2) in molecular docking technology.The homology model of hCNT2 was produced, and then the Vina software was employed to virtual screen the Chicory compound combined with CNT2. Compared with 7,8,3'-trihydroxyflavone, a CNT2 inhibitors, 23 score higher chicory compounds were hit.Meanwhile, the ten top compounds have been revealed that play important role in decrease the uric level. The bioactivity to CNT2 needs to be investigatedin experiment...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929662/-effect-of-astragaloside-on-mrna-expression-of-pi3k-akt-mtor-signal-transduction-in-anemia-model-mice-induced-by-chemotherapy
#6
Tie Qiao, Ke Liang, Jin Ma, Shu-Ru Lin, Bing-Yuan Zheng, Li-de Zhang
To study the influence of astragaloside on mRNA expression of PI3K/Akt/mTOR signal transduction in anemia model mice induced by chemotherapy, 48 male BALB/c mice which were 6-7 week old were picked as the research objects and randomly divided into four groups, blank group, model group, astragaloside group and astragaloside IV group. Each group was 12 mice. Chemotherapy anemia model was established by cyclophosphamide. The mice were drawn blood from eyeball after 14 days treatment. The QPCR was used to test the mRNA concentrations of Akt, PI3K, BCL-xl, bad, FoxO, mTOR, PTEN in mouse spleen...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929584/association-between-oral-leukoplakia-and-risk-of-upper-gastrointestinal-cancer-death-a-follow-up-study-of-the-linxian-general-population-trial
#7
He Liang, Zhao Yang, Jian-Bing Wang, Pei Yu, Jin-Hu Fan, You-Lin Qiao, Philip R Taylor
BACKGROUND: This study was conducted to explore the association between oral leukoplakia (OL) and the risk of upper gastrointestinal cancer death in the Linxian General Population Trial Cohort. METHODS: A prospective cohort study of the Linxian General Population Trial Cohort was performed. Participants with OL were treated as an exposed group, and the remainder was selected as a control group. All subjects were followed monthly by village health workers and reviewed quarterly by the Linxian Cancer Registry...
September 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28928892/the-targeted-antitumor-effects-of-c-pc-cmc-cd59sp-nanoparticles-on-hela-cells-in-vitro-and-in-vivo
#8
Yujuan Wang, Liangqian Jiang, Qifeng Yin, Huihui Liu, Guoxiang Liu, Guoteng Zhu, Bing Li
The novel C-PC/CMC-CD59sp-NPs were made by carbocymethyl chitosan (CMC) loading C-phycocyanin (C-PC) with the lead of CD59 specific ligand peptide (CD59sp) for targeting, and the characteristics and targeted anti-tumor mechanism were explored in order to realize the targeted therapy of C-PC on the growth of HeLa cells both in vitro and vivo. The targeting nanoparticles were synthesized by ionic-gelation method, and the optimal condition was selected out by orthogonal analysis. The properties of nanoparticles were observed by laser particle analyzer and dynamic light scattering (DLS) and Fourier Transform Infrared Spectrometer (FTIR)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928847/anti-angiogenic-effect-of-arsenic-trioxide-in-lung-cancer-via-inhibition-of-endothelial-cell-migration-proliferation-and-tube-formation
#9
Meng-Hang Yang, Ke-Jie Chang, Jin-Cheng Zheng, Hai Huang, Guang-Yuan Sun, Xue-Wei Zhao, Bing Li, Qing-Yu Xiu
Arsenic trioxide (As2O3) exhibits a remarkable effect on leukemia treatment; however, its effect on solid tumors remains poorly explored. The present study demonstrated the inhibitory effect of As2O3 on lung cancer and explored its possible mechanism. It was observed that As2O3 significantly inhibited the growth of lung cancer xenografts and tumor angiogenesis in vivo. The inhibitory effect of As2O3 on cell proliferation in vitro was more remarkable in vascular endothelial cells than in lung cancer cells. It was also observed that As2O3 inhibited the migration of vascular endothelial cells and disrupted vascular tube formation on Matrigel assays...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928835/t-cadherin-is-associated-with-prognosis-in-triple-negative-breast-cancer
#10
De-Di Kong, Mei-Hong Wang, Jie Yang, Liang Li, Wei Wang, Shi-Bing Wang, Yan-Zhen Zhou
The purpose of the present study was to assess the prognostic impact of T-cadherin expression in patients with triple-negative breast cancer (TNBC). On the basis of the results of immunohistochemical analysis, 106 patients with operable TNBC were divided into two groups, the T-cadherin-positive group and T-cadherin-negative group. Fisher's exact and χ(2) tests were employed to analyze clinical data, which included the association between T-cadherin expression and clinicopathological features and prognosis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928639/microglia-polarization-with-m1-m2-phenotype-changes-in-rd1-mouse-model-of-retinal-degeneration
#11
Tian Zhou, Zijing Huang, Xiaowei Sun, Xiaowei Zhu, Lingli Zhou, Mei Li, Bing Cheng, Xialin Liu, Chang He
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood. This study aimed to elucidate the time-spatial pattern of microglia distribution and characterize the polarized phenotype of activated microglia during retinal neuroinflammation and degeneration in rd1 (Pde6β(rd1/rd1)) mice, the classic model of inherited retinal degeneration. Retinae of rd1 mice at different postnatal days (P7, P14, P21, P28, P56, and P180) were prepared for further analysis...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28928473/hymerhabdrin-a-a-novel-diterpenoid-with-antifouling-activity-from-the-intertidal-sponge-hymerhabdia-sp
#12
Sheng-Tao Fang, Bing-Fei Yan, Cui-Yun Yang, Feng-Ping Miao, Nai-Yun Ji
Hymerhabdrin A (1), a diterpenoid possessing a novel 6/6/5 fused-ring skeleton, together with four known sterols were isolated from an intertidal marine sponge Hymerhabdia sp. Their structures were elucidated by extensive spectroscopic methods, and the relative and absolute configurations of 1 were determined by NOESY analysis and electronic circular dichrosim calculations, respectively. Hymerhabdrin A (1) exhibited significant antifouling activity against Balanus amphitrite larval with LC50 (lethal concentration 50) value of 3...
September 20, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28928447/the-roles-of-wettability-and-surface-tension-in-droplet-formation-during-inkjet-printing
#13
Bing He, Sucui Yang, Zhangrong Qin, Binghai Wen, Chaoying Zhang
This paper describes a lattice Boltzmann-based binary fluid model for inkjet printing. In this model, a time-dependent driving force is applied to actuate the droplet ejection. As a result, the actuation can be accurately controlled by adjusting the intensity and duration of the positive and negative forces, as well as the idle time. The present model was verified by reproducing the actual single droplet ejection process captured by fast imaging. This model was subsequently used to investigate droplet formation in piezoelectric inkjet printing...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928367/characterization-of-a-new-member-of-iridoviridae-shrimp-hemocyte-iridescent-virus-shiv-found-in-white-leg-shrimp-litopenaeus-vannamei
#14
Liang Qiu, Meng-Meng Chen, Xiao-Yuan Wan, Chen Li, Qing-Li Zhang, Ruo-Yu Wang, Dong-Yuan Cheng, Xuan Dong, Bing Yang, Xiu-Hua Wang, Jian-Hai Xiang, Jie Huang
A newly discovered iridescent virus that causes severe disease and high mortality in farmed Litopenaeus vannamei in Zhejiang, China, has been verified and temporarily specified as shrimp hemocyte iridescent virus (SHIV). Histopathological examination revealed basophilic inclusions and pyknosis in hematopoietic tissue and hemocytes in gills, hepatopancreas, periopods and muscle. Using viral metagenomics sequencing, we obtained partial sequences annotated as potential iridoviridae. Phylogenetic analyses using amino acid sequences of major capsid protein (MCP) and ATPase revealed that it is a new iridescent virus but does not belong to the five known genera of Iridoviridae...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928080/vascular-endothelial-growth-factor-driving-aberrant-keratin-expression-pattern-contributes-to-the-pathogenesis-of-psoriasis
#15
Man Jiang, Bing Li, Jieyu Zhang, Lei Hu, Erle Dang, Gang Wang
Psoriasis is a chronic inflammatory skin disease severely affecting patients' physical and psychological well-being. Aberrant keratin expression in psoriasis plays a crucial role in keratinocyte dysfunction and disease development. Little is yet known about the mechanism of this keratin dysregulation. VEGF (Vascular endothelial growth factor) is significantly elevated in psoriatic patients and VEGFRs are detected on keratinocytes, leading to our hypothesis that this keratin dysregulation may be regulated by VEGF...
September 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28927776/-gluten-is-the-information-available-on-the-internet-valid
#16
T Banti, L Fievet, A Fabre
BACKGROUND: Internet provides easy access to health information, but the quality and validity of this information vary. OBJECTIVES: Evaluate the quality of website structures and the information provided on celiac disease (CD), gluten sensitivity (GS), and wheat allergy (WA). MATERIALS AND METHODS: The websites addressing CD, GS, and WA appearing on the first two pages of Google, Yahoo, and Bing from seven selected queries were investigated...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28927613/physicochemical-transformation-of-rice-straw-after-pretreatment-with-a-deep-eutectic-solvent-of-choline-chloride-urea
#17
Mingzhu Pan, Guomin Zhao, Chunxiang Ding, Bing Wu, Zhina Lian, Hailan Lian
This study focused on the pretreatment with deep eutectic solvent of choline chloride (ChCl)/urea mixtures on rice straw and its chemical fractions of holocellulose, α-cellulose, and acid-insoluble-lignin (AIL). The pretreatment of ChCl/urea was significantly affected by the treated temperature prior to the treated time, and 130°C and 4h was an optimum condition for ChCl/urea pretreatment. The separation capacity of ChCl/urea on the chemical fractions was in an order of AIL (22.87%)> hemicellulose and amorphous cellulose (16...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927143/an-early-superficial-non-ampullary-duodenal-tumor-cured-with-endoscopic-submucosal-dissection-a-case-report
#18
Yi Wei Fu, Mao Song Lin, Bing Yang, Hong Yu, Xia Jiao, Jun Xing Huang
Early superficial non-ampullary duodenal tumors are particularly rare, the clinical manifestations, including typical endoscopic or imaging features, and treatment methods are not well-characterized. The present case report describes a case of an asymptomatic 74-year-old male who presented to the Taizhou People's Hospital (Taizhou, China) for a regular health screening, where a primary superficial non-ampullary duodenal tumor was identified. Upper endoscopy revealed ~1.2 cm lesion in the second portion of the duodenum...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926917/chemical-enzymatic-conversion-of-corncob-derived-xylose-to-furfuralcohol-by-the-tandem-catalysis-with-so4-2-sno2-kaoline-and-e-coli-cczu-t15-cells-in-toluene-water-media
#19
Yu-Cai He, Chun-Xia Jiang, Gang-Gang Chong, Jun-Hua Di, Yan-Fei Wu, Bing-Qian Wang, Xin-Xia Xue, Cui-Luan Ma
One-pot synthesis of furfuralcohol from corncob-derived xylose was attempted by the tandem catalysis with solid acid SO4(2-)/SnO2-kaoline and recombination Escherichia coli CCZU-T15 whole-cells in the toluene-water media. Using SO4(2-)/SnO2-kaoline (3.5wt%) as catalyst, the furfural yield of 74.3% was obtained from corncob-derived xylose in the toluene-water (1:2, v:v) containing 10mM OP-10 at 170°C for 30min. After furfural liquor was mixed with corncob-hydrolysate from the enzymatic hydrolysis of oxalic acid-pretreated corncob residue, furfural (50...
September 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926739/electrophysiological-correlates-of-performance-monitoring-in-binge-drinking-impaired-error-related-but-preserved-feedback-processing
#20
Séverine Lannoy, Fabien D'Hondt, Valérie Dormal, Joël Billieux, Pierre Maurage
OBJECTIVE: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of risky behaviors, the present study aimed at determining the behavioral and electrophysiological correlates of the cognitive (inhibition) and motivational (reward sensitivity) systems during performance monitoring...
September 2, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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