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https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#1
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732367/significantly-more-intense-pain-in-methadone-maintained-patients-who-are-addicted-to-nicotine
#2
Lian-Zhong Liu, Lin-Xiang Tan, Yan-Min Xu, Xue-Bing Liu, Wen-Cai Chen, Jun-Hong Zhu, Jin Lu, Bao-Liang Zhong
Pain and cigarette smoking are very common in heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT) and both have substantial negative effects on HDPs' physical and mental health. Nevertheless, very few studies have assessed the relationship between the two in HDPs. This study examined the association between pain intensity and smoking in Chinese methadone-maintained HDPs. A total of 603 HDPs were consecutively recruited from three MMT clinics in Wuhan, China, and administered with a socio-demographic and drug use questionnaire, a smoking questionnaire concerning average number of cigarettes smoked daily and Heaviness of Smoking Index, and Zung's Self-rating Depression Scale...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732353/serum-insulin-like-growth-factor-1-and-its-binding-protein-3-as-prognostic-factors-for-the-incidence-progression-and-outcome-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#3
Jing Wang, Yu-Chuan Li, Min Deng, Hai-Yin Jiang, Li-Hua Guo, Wen-Juan Zhou, Bing Ruan
PURPOSE: Previous studies have supported an association between serum insulin-like growth factor 1 (IGF1) and IGF-binding protein 3 (IGFBP3) levels and hepatocellular carcinoma (HCC), but the results were inaccurate. It has recently been proposed that IGF1 and IGFBP3 play roles in the time-to-progression (TTP) and overall survival (OS) of HCC patients. Our results revealed that serum IGF1 level is predictive of the progression and survival of HCC patients. RESULTS: HCC was associated with a significant reduction in serum IGF-1 and IGFBP-3 levels compared to cirrhosis (p = 0...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732319/did-the-dependent-coverage-expansion-increase-risky-substance-use-among-young-adults
#4
Joshua Breslau, Hao Yu, Bing Han, Rosalie L Pacula, Rachel M Burns, Bradley D Stein
BACKGROUND: The dependent coverage expansion (DCE) enacted through the Affordable Care Act increased health insurance coverage among young adults. Increasing insurance coverage in this age group has the potential for unintended consequences on risky substance use. METHODS: Repeated cross-sectional surveys were used to compare change in substance use during the period the DCE was implemented in the 19-25year old target age group (Pre-DCE n=15,772, Post-DCE n=22,719) with contemporaneous change in a slightly older age group that was not targeted by the policy (Pre-DCE=19,851, Post-DCE n=28,157)...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28731336/triple-reuptake-inhibitors-as-potential-therapeutics-for-depression-and-other-disorders-design-paradigm-and-developmental-challenges
#5
Murugaiah A M Subbaiah
Although first-line antidepressants offer therapeutic benefit, about 35% of depressed patients are not adequately treated, creating a large unmet medical need. These medicines mostly enhance the synaptic levels of serotonin and/or norepinephrine. Evidence from preclinical and clinical studies implicate dopamine hypofunction in the pathophysiology of depression. Triple reuptake inhibitors (TRIs), which elevate dopamine in addition to serotonin and norepinephrine, may demonstrate greater efficacy, with the reversal of anhedonia and improved tolerability...
July 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28731264/high-yield-synthesis-of-crystal-phase-heterostructured-4h-fcc-au-pd-core-shell-nanorods-for-electrocatalytic-ethanol-oxidation
#6
Ye Chen, Zhanxi Fan, Zhimin Luo, Xiaozhi Liu, Zhuangchai Lai, Bing Li, Yun Zong, Lin Gu, Hua Zhang
Noble-metal nanomaterials are attracting increasing research interest due to their promising applications in electrochemical catalysis, for example. Although great efforts have been devoted to the size-, shape-, and architecture-controlled synthesis of noble-metal nanomaterials, their crystal-phase-controlled synthesis is still in its infancy. Here, for the first time, this study reports high-yield synthesis of Au nanorods (NRs) with alternating 4H/face-centered cubic (fcc) crystal-phase heterostructures via a one-pot wet-chemical method...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28731224/extremely-low-density-and-super-compressible-graphene-cellular-materials
#7
Ling Qiu, Bing Huang, Zijun He, Yuanyuan Wang, Zhiming Tian, Jefferson Zhe Liu, Kun Wang, Jingchao Song, Thomas R Gengenbach, Dan Li
Development of extremely low density graphene elastomer (GE) holds the potential to enable new properties that traditional cellular materials cannot offer, which are promising for a range of emerging applications, ranging from flexible electronics to multifunctional scaffolds. However, existing graphene foams with extremely low density are generally found to have very poor mechanical resilience. It is scientifically intriguing but remains unresolved whether and how the density limit of this class of cellular materials can be further pushed down while their mechanical resilience is being retained...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28731181/mir%C3%A2-21-promotes-%C3%AE-%C3%A2-sma-and-collagen-i-expression-in-hepatic-stellate-cells-via-the-smad7-signaling-pathway
#8
Rong-Quan Fu, Dan-Ping Hu, Yi-Bing Hu, Liang Hong, Qing-Feng Sun, Ji-Guang Ding
The aim of the present study was to investigate the role of microRNA (miR)‑21 in regulating collagen I and Smad7 expression in activated rat hepatic stellate cells (HSCs). Rat HSCs were isolated by single‑step density gradient centrifugation with Nycodenz. Cellular content of miR‑21, SMAD7, α‑smooth muscle actin (α‑SMA), collagen type I alpha 1 (COLLA1) and COLL alpha 2 (A2) mRNA was examined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), and cellular content of Smad7 and α‑SMA protein was detected by western blotting...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731161/investigation-of-the-molecular-mechanisms-underlying-myotonic-dystrophy-types-1-and-2-cataracts-using-microrna%C3%A2-target-gene-networks
#9
Dewang Shao, Xiaoquan Zhu, Wei Sun, Lu Huo, Wei Chen, Hua Wang, Bing Liu, Peng Pan
The purpose of the present study was to investigate the molecular mechanisms of myotonic dystrophy (DM) 1 and 2 cataracts using bioinformatics methods. A microarray dataset (E‑MEXP‑3365) downloaded from the Array Express database included lens epithelial samples of DM1 and DM2 cataract patients (n=3/group) and non‑DM lens epithelial samples as a control (n=4). Differentially expressed genes (DEGs) were identified between DM1 and control samples, and between DM2 and control samples. Pathway enrichment analyses were performed for the DEGs...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731139/inhibitory-effects-of-fkbp14-on-human-cervical-cancer-cells
#10
Lian-Yi Sun, Jiu-Zhi Tao, Bing Yan, Jian-Shu Lin
The FK506-binding protein 14 (FKBP14), which belongs to a subfamily of immunophilins, has been implicated in various biochemical processes. However, its effects on human cervical cancer remain to be elucidated. The present study aimed to determine the exact role of FKBP14 in human cervical cancer cell proliferation, cell cycle progression, apoptosis, invasion and migration. Cell proliferation was measured by Cell Counting Kit‑8 assay. Flow cytometry was conducted to determine the effects of FKBP14 on cell cycle progression and apoptosis...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730801/impact-of-metal-contacts-to-the-performance-of-multilayer-hfs2-field-effect-transistors
#11
Xin-Ran Nie, Bing-Qi Sun, Hao Zhu, Min Zhang, Dong-Hui Zhao, Lin Chen, Qing-Qing Sun, David Wei Zhang
HfS2 is one of the emerging transition metal dichalcogenides and is very promising for low-power nanoelectronics and high-sensitivity optoelectronic device applications. We studied the band structures of 1T-HfS2 with different thickness by first principles simulation, and the impact of different metal contacts to the HfS2 device performance has been experimentally studied. Back-gate and top-gate HfS2 field-effect transistors (FETs) were fabricated, and better electrical characteristics have been achieved with the FETs with Ti/Au contact as compared with the Pt-contacted FETs...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730785/pdcd1-strengthens-the-sensitivity-of-ovarian-cancer-to-cisplatin-chemotherapy-by-promoting-apoptosis
#12
Qian Li, Jie-Fan Gao, Bing-Li Qi
PURPOSE: The primary purpose of this study was to make clear the role of PDCD1 in the occurrence and progression of ovarian cancer, and explain its mechanism. METHODS: RT-PCR, westem blot, MTT and immunohistochemistry were used to detect the expression levels of PDCD1 mRNA and protein in human ovarian cancer cell lines (SKOV3, 3AO, CAOV3 and OVCAR3), human normal ovary, serous cystadenoma, and serous cystadenocarcinoma tissue. SKOV3, SKOV3-MOCK, and SKOV3-PDCD1 cells were subcutaneously injected into the armpit of nude mice to observe the effect of PDCD1 expression on tumorigenic ability...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730521/complete-genomic-sequence-of-a-duck-enteritis-virus-attenuated-via-serial-passage-in-chick-embryos
#13
Chenghuai Yang, Bing Zhang, Junping Li, Xiaojie Huang, Dan Liu, Lidan Hou, Qihong Li, Huijiao Li
Here, we present the complete genomic sequence of an attenuated duck enteritis virus (DEV). The Chinese standard challenge strain of DEV (DEV CSC) was serially passaged 20 times in chick embryo fibroblasts and then 85 times in chick embryos. The virus was attenuated and was avirulent to 2-month-old ducks. The attenuated DEV genome is 162,131 base pairs (bp) in length and as long as the parental genomic sequence. There are only 22 nucleotide substitutions, resulting in single amino acid changes in open reading frames LORF5, LORF4, UL41, UL39, UL32, UL13, UL10, UL3, US3, US4 and US7...
July 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28730113/increased-aquaporin-1-levels-in-lens-epithelial-cells-with-primary-angle-closure-glaucoma
#14
Lei Cheng, Bing Long, Xin-Xing Guo, Li-Xin Li, Yue Xu, Lin-Lin Hao, Dan-Ying Zheng, Bing Cheng, Xing Liu
AIM: To determine the levels of aquaporin-1 (AQP-1) in the lens epithelial cells (LECs) of primary glaucoma and to clarify its correlation with lens thickness. METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma (APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma (CPACG) and 20 eyes of 20 patients with primary open angle glaucoma (POAG)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730101/comparative-analysis-of-different-feeder-layers-with-3t3-fibroblasts-for-culturing-rabbits-limbal-stem-cells
#15
Hui-Xian Wang, Xiao-Wei Gao, Bing Ren, Yan Cai, Wen-Jing Li, Yu-Li Yang, Yi-Jian Li
AIM: To explore the possibility of human umbilical cord mesenchymal stem cells (hUCMSCs), human umbilical vein endothelial cells (hUVECs), human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs) serving as feeder cells in co-culture systems for the cultivation of limbal stem cells. METHODS: Different feeder layers were cultured in Dulbecco's modified Eagle's medium (DMEM)/F12 and were treated with mitomycin C. Rabbits limbal stem cells (LSCs) were co-cultured on hUCMSCs, hUVECs, hDPSCs, hPDLSCs and NIH-3T3, and then comparative analysis were made between each group to see their respective colony-forming efficiency (CFE) assay and immunofluorescence (IPO13,CK3/12)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730092/parameters-of-ocular-fundus-on-spectral-domain-optical-coherence-tomography-for-glaucoma-diagnosis
#16
REVIEW
Yu-Lin Tao, Li-Ming Tao, Zheng-Xuan Jiang, He-Ting Liu, Kun Liang, Mo-Han Li, Xuan-Sheng Zhu, Yan-Lin Ren, Bing-Jie Cui
In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography (SD-OCT) in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer (RNFL) thickness is essential. Imaging and analysis of retinal ganglion cells (RGCs) and inner plexiform layer (IPL), respectively, have been of great importance. Optic nerve head (ONH) topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch's membrane opening (BMO), estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729884/genome-wide-landscape-of-position-effects-on-heterogeneous-gene-expression-in-saccharomyces-cerevisiae
#17
Xiao-Le Wu, Bing-Zhi Li, Wen-Zheng Zhang, Kai Song, Hao Qi, Jun-Biao Dai, Ying-Jin Yuan
BACKGROUND: Integration of heterogeneous genes is widely applied in synthetic biology and metabolic engineering. However, knowledge about the effect of integrative position on gene expression remains limited. RESULTS: We established a genome-wide landscape of position effect on gene expression in Saccharomyces cerevisiae. The expression cassette of red fluorescence protein (RFP) gene was constructed and inserted at 1044 loci, which were scattered uniformly in the yeast genome...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28729845/negative-affect-and-excessive-alcohol-intake-incubate-during-protracted-withdrawal-from-binge-drinking-in-adolescent-but-not-adult-mice
#18
Kaziya M Lee, Michal A Coehlo, Noah R Solton, Karen K Szumlinski
Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of development. Prior work indicated that adolescent male C57BL6/J mice with a 2-week history of binge-drinking (PND28-41) are resilient to the anxiogenic effects of early alcohol withdrawal. Herein, we employed a comparable Drinking-in-the-Dark model to determine how a prior history of binge-drinking during adolescence (EtOH(adolescents)) influences emotionality (assayed with the light-dark box, marble burying test, and the forced swim test) and the propensity to consume alcohol in later life, compared to animals without prior drinking experience...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28729808/paleoseismic-study-of-the-kamishiro-fault-on-the-northern-segment-of-the-itoigawa-shizuoka-tectonic-line-japan
#19
Aiming Lin, Mikako Sano, Maomao Wang, Bing Yan, Di Bian, Ryoji Fueta, Takashi Hosoya
The Mw 6.2 (Mj 6.8) Nagano (Japan) earthquake of 22 November 2014 produced a 9.3-km long surface rupture zone with a thrust-dominated displacement of up to 1.5 m, which duplicated the pre-existing Kamishiro Fault along the Itoigawa-Shizuoka Tectonic Line (ISTL), the plate-boundary between the Eurasian and North American plates, northern Nagano Prefecture, central Japan. To characterize the activity of the seismogenic fault zone, we conducted a paleoseismic study of the Kamishiro Fault. Field investigations and trench excavations revealed that seven morphogenic paleohistorical earthquakes (E2-E8) prior to the 2014 Mw 6...
2017: Journal of Seismology
https://www.readbyqxmd.com/read/28728632/binge-drinking-episodes-in-young-adults-how-should-we-measure-them-in-a-research-setting
#20
Mariann R Piano, Adriana Mazzuco, Minkyung Kang, Shane A Phillips
OBJECTIVE: Worldwide, consequences of binge drinking are a major health and policy concern. This article reviews contemporary binge drinking definitions as well as different questionnaires and biomarkers that have been used in research settings to examine binge drinking behavior among young adults. METHOD: A review of electronic databases was conducted for binge drinking definitions, questionnaires, and biomarkers for the measurement of binge drinking in young adults (18-30 years)...
July 2017: Journal of Studies on Alcohol and Drugs
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