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https://www.readbyqxmd.com/read/28097915/the-relationship-between-angiotensin-converting-enzyme-ace-insertion-i-deletion-d-polymorphism-serum-ace-activity-and-bone-mineral-density-bmd-in-older-chinese
#1
Ya-Feng Zhang, Hong Wang, Qiong Cheng, Ling Qin, Nelson Ls Tang, Ping-Chong Leung, Timothy Cy Kwok
OBJECTIVE: In this study, we set out to investigate the relationship between angiotensin-converting enzyme ( ACE) I/D polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese. METHODS: A standardized, structured, face-to-face interview was performed to collect demographic information. BMD was measured using dual-energy X-ray absorptiometry (DXA). I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Serum ACE activity was determined photometrically by a commercially available kinetic kit...
January 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28097118/femur-neck-fracture-in-a-young-marfan-syndrome-patient
#2
Yong-Uk Kwon, Gyu-Min Kong, Jun-Ho Park
Marfan syndrome is an autosomal dominant and could decrease bone mineral density. So patients with Marfan syndrome could vulnerable to trauma in old ages. We present the first report, to the best of our knowledge, of a rare fracture of the femoral neck with a minor traumatic history in a juvenile Marfan syndrome patient whose physis is still open. Although the patient is young, her bone mineral density was low and the geometry of femur is changed like old ages. The femur neck fracture in children is very rare and only caused by high energy trauma, we concluded that the Marfan syndrome makes the bone weaker in young age and preventative medications to avoid fractures in younger Marfan syndrome patients are necessary in early ages...
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28097110/comparative-study-of-bipolar-hemiarthroplasty-for-femur-neck-fractures-treated-with-cemented-versus-cementless-stem
#3
Jung-Yun Choi, Yerl-Bo Sung, Joo-Hyung Kim
PURPOSE: To compare and analyze clinical and radiologic outcomes of cemented versus cementless bipolar hemiarthroplasty for treatment of femur neck fractures. MATERIALS AND METHODS: A total of 180 patients aged 65 years and over older who underwent bipolar hemiarthroplasty for treatment of displaced femur neck fractures (Garden stage III, IV) from March 2009 to February 2014 were included in this study. Among the 180 patients, 115 were treated with cemented stems and 65 patients with cementless stems...
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28096639/association-between-serum-25-hydroxyvitamin-d-levels-and-bone-mineral-density-in-normal-postmenopausal-women
#4
Vasundhara Kamineni, Akkenapally Prasanna Latha, K Ramathulasi
AIM: This study was conducted with the objective of assessing serum 25-hydroxyvitamin D (25(OH)D) in postmenopausal women (PMW), to detect osteopenia or osteoporosis in PMW and to establish a correlation between serum 25(OH)D levels and bone mineral density (BMD). MATERIALS AND METHODS: A total of 100 healthy PMW were selected, and a prospective observational study was conducted to correlate the BMD with serum 25(OH)D levels. Their laboratory investigations along with serum 25(OH)D levels were done...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28093633/dietary-potassium-intake-is-beneficial-to-bone-health-in-a-low-calcium-intake-population-the-korean-national-health-and-nutrition-examination-survey-knhanes-2008-2011
#5
S H Kong, J H Kim, A R Hong, J H Lee, S W Kim, C S Shin
: Dietary potassium may neutralize acid load and reduce calcium loss from the bone, leading to beneficial effect on bone mineral density. In this nationwide Korean population study, dietary potassium intake was associated with improved bone mineral density in older men and postmenopausal women. INTRODUCTION: Nutrition is a major modifiable factor that affects bone health. The accompanying anion in dietary potassium may act as an alkaline source by neutralizing the acid load and reducing calcium loss from the bone...
January 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28089085/the-timing-of-bone-spect-to-predict-osteonecrosis-after-internal-fixation-of-femur-neck-fractures
#6
Ji Wan Kim, Jin-Sook Ryu, Sora Baek, Seong-Eun Byun, Jae Suk Chang
BACKGROUND: Bone SPECT can be used after a femur neck fracture to assess the circulation of the femoral head in the immediate postoperative period because the blood supply is one of the major factors affecting bone uptake of radiotracer on bone scintigraphy. The purpose of our present study was to investigate whether osteonecrosis of the femoral head (OFH) after internal fixation of femoral neck fracture could be predicted by early and late bone SPECT. METHODS: This retrospective cohort study enrolled 44 patients (33 women; mean age, 66...
January 6, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28073094/the-role-of-lesser-trochanter-fragment-in-unstable-pertrochanteric-a2-proximal-femur-fractures-is-refixation-of-the-lesser-trochanter-worth-the-effort
#7
Christian Ehrnthaller, Alain Christoph Olivier, Florian Gebhard, Lutz Dürselen
BACKGROUND: Instability of osteoporotic pertrochanteric fractures is defined by loss of medial/lateral cortical integrity with the posteromedial fragment including the lesser trochanter being pivotal for load distribution. Literature addressing the importance of lesser trochanter refixation is scarce. To clarify the effect of lesser trochanter refixation on primary stability in these fractures, following study was performed. METHODS: 21 femora were match-paired in 3 groups and osteotomized, creating pertrochanteric fractures (AO-31A2)...
December 30, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/28069346/prevalence-and-severity-of-bone-loss-in-burned-patients
#8
Aria Partovi, Alireza Dabaghmanesh, Sharareh Roshanzamir
Often discovered late during the clinical course of burns, bone loss is widely accepted by clinicians as a de facto consequence of burn. Literature on this bone loss is limited and contradictory in details. More insight into the prevalence and magnitude of bone loss may facilitate its prevention. To this end, over a period of two years, we gathered a test group of 34 male patients with at least six-month-old thermal burns and a control group of 50 male members of similar age and geographical background as our test group...
January 6, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28067568/improving-community-prescribing-of-post-fracture-denosumab-after-discharge
#9
Helen Wood, Harriet Lewis, Rachael Ward, Tarun Solanki, Prabhath Fernando
BACKGROUND: In the UK, denosumab is usually started by hospital clinicians and continued by primary care physicians in the community, but in the authors' region denosumab is a 'green light' drug, only prescribed by the primary care team. The authors suspected that a proportion of patients who were recommended to start the drug after a neck of femur fracture were not receiving this on discharge. They aimed to improve the prescribing of denosumab by implementing a quality improvement project...
January 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28060768/a-novel-osteoporosis-model-with-ascorbic-acid-deficiency-in-akr1a1-gene-knockout-mice
#10
Cheng-Wei Lai, Hsiao-Ling Chen, Min-Yu Tu, Wei-Yu Lin, Theresa Röhrig, Shang-Hsun Yang, Ying-Wei Lan, Kowit-Yu Chong, Chuan-Mu Chen
The AKR1A1 protein is a member of the aldo-keto reductase superfamily that is responsible for the conversion of D-glucuronate to L-gulonate in the ascorbic acid (vitamin C) synthesis pathway. In a pCAG-eGFP transgenic mouse line that was produced by pronuclear microinjection, the integration of the transgene resulted in a 30-kb genomic DNA deletion, including the Akr1A1 gene, and thus caused the knockout (KO) of the Akr1A1 gene and targeting of the eGFP gene. The Akr1A1 KO mice (Akr1A1eGFP/eGFP) exhibited insufficient serum ascorbic acid levels, abnormal bone development and osteoporosis...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28053824/low-normal-tsh-levels-are-associated-with-impaired-bmd-and-hip-geometry-in-the-elderly
#11
Su Jin Lee, Kyoung Min Kim, Eun Young Lee, Mi Kyung Song, Dae Ryong Kang, Hyeon Chang Kim, Yoosik Youm, Young Mi Yun, Hyun-Young Park, Chang Oh Kim, Yumie Rhee
Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28050531/femoroacetabular-impingement
#12
REVIEW
José Batista Volpon
The femoroacetabular impingement (FAI) is as condition recently characterized that results from the abnormal anatomic and functional relation between the proximal femur and the acetabular border, associated with repetitive movements, which lead labrum and acetabular cartilage injuries. Such alterations result from anatomical variations such as acetabular retroversion or decrease of the femoroacetabular offset. In addition, FAI may result from acquired conditions as malunited femoral neck fractures, or retroverted acetabulum after pelvic osteotomies...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28049234/chronic-kidney-disease-mineral-bone-disorder-in-korean-patients-a-report-from-the-korean-cohort-study-for-outcomes-in-patients-with-chronic-kidney-disease-know-ckd
#13
Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Seung Hyeok Han, Kyu Beck Lee, Joongyub Lee, Kook Hwan Oh, Dong Wan Chae, Soo Wan Kim
This study examined the characteristics of biochemical parameters, bone diseases, and vascular calcification in Korean patients with chronic kidney disease (CKD) not yet on dialysis. Serum levels of fibroblast growth factor 23 (FGF23), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D3 (25D), and 1,25-dihydroxyvitamin D3 (1,25D); lumbar spine, total hip, and femur neck bone mineral densities; and brachial-to-ankle pulse wave velocity (baPWV) representing vascular calcification were measured at baseline for 2,238 CKD patients in the KoreaN Cohort Study for Outcomes in Patients With CKD (KNOW-CKD)...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28045945/greater-intake-of-fruit-and-vegetables-is-associated-with-greater-bone-mineral-density-and-lower-osteoporosis-risk-in-middle-aged-and-elderly-adults
#14
Rui Qiu, Wen-Ting Cao, Hui-Yuan Tian, Juan He, Geng-Dong Chen, Yu-Ming Chen
OBJECTIVE: A few studies have suggested that the consumption of fruit and vegetables (FV) may benefit bone health, but limited data are available in Asian subjects. We examined the association between FV intake and bone mineral density (BMD) and osteoporosis in Chinese adults. METHODS: This population-based cross-sectional study involved 2083 women and 1006 men aged 40-75 years in Guangzhou, China. Habitual dietary data was collected from a 79-item food frequency questionnaire by face-to-face interviews...
2017: PloS One
https://www.readbyqxmd.com/read/28043896/marrow-adipose-tissue-composition-in-adults-with-morbid-obesity
#15
Elaine W Yu, Logan Greenblatt, Alireza Eajazi, Martin Torriani, Miriam A Bredella
Patients with type 2 diabetes mellitus (T2DM) have increased fracture risk despite normal or increased bone mineral density (BMD). Elevations in marrow adipose tissue (MAT) and declines in MAT unsaturation are both associated with increased skeletal fragility. The objective of our study was to characterize the quantity and composition of MAT in adults with morbid obesity and T2DM, and to evaluate determinants of MAT. We studied 21 adults with morbid obesity prior to bariatric surgery, 8 of whom had T2DM. All subjects underwent 1H-MR spectroscopy of the lumbar spine and femur for assessment of MAT and dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) of the lumbar spine and hip for assessment of areal BMD (aBMD) and volumetric BMD (vBMD)...
December 30, 2016: Bone
https://www.readbyqxmd.com/read/28034591/women-with-polycystic-ovary-syndrome-have-comparable-hip-bone-geometry-to-age-matched-control-women
#16
Laura E McBreairty, Gordon A Zello, Julianne J Gordon, Shani B Serrao, Roger A Pierson, Donna R Chizen, Philip D Chilibeck
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28031507/combined-use-of-ibandronate-and-eldecalcitol-in-postmenopausal-japanese-women-with-osteoporosis
#17
Junichi Takada, Hiroshi Wada, Kousuke Iba, Kouichi Sasaki, Takayuki Dohke, Kumiko Kanaya, Takashi Yoshizaki, Toshihiko Yamashita
PURPOSE: To evaluate the effect of combined use of ibandronate and eldecalcitol for 6 to 12 months on bone mineral density (BMD) and bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis. METHODS: BMD and bone strength of the proximal femur were evaluated in 78 postmenopausal women (mean age, 73.6 years) who underwent treatment for osteoporosis with combined use of ibandronate and eldecalcitol for at least 6 months. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry (DXA) at baseline and every 6 months thereafter...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28026203/sexual-dimorphism-in-bone-muscle-relationship-in-young-adults
#18
Vera Zymbal, Kathleen F Janz, Fátima Baptista
The purpose of this study was to analyse associations between lean soft tissue (LST), a surrogate of skeletal muscle mass and key fracture-related geometric characteristics of the proximal femur. Moreover, we examined the role that muscle played on the proximal femur geometry in response to physical activity (PA). Participants were 83 young adults. Leg LST (exposure) was assessed by dual energy X-ray absorptiometry (DXA). Proximal femur geometry was derived from a left hip DXA scan. Geometric variables (outcomes) included the femoral neck axis length (FNAL), the femoral neck width (FNW), the neck-shaft angle and FNW|FNAL (an index of robustness)...
December 27, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28019683/effect-of-teriparatide-or-risedronate-in-elderly-patients-with-a-recent-pertrochanteric-hip-fracture-final-results-of-a-78-week-randomized-clinical-trial
#19
Jorge Malouf-Sierra, Umberto Tarantino, Pedro A García-Hernández, Costantino Corradini, Søren Overgaard, Jan J Stepan, Lars Borris, Eric Lespessailles, Frede Frihagen, Kyriakos Papavasiliou, Helmut Petto, Per Aspenberg, José Ramón Caeiro, Fernando Marin
We present final results of a study comparing teriparatide 20 µg QD with risedronate 35 mg QW started within 2 weeks after surgery for a pertrochanteric hip fracture. Patients with BMD T-score ≤-2.0 and 25OHD >9.2 ng/mL were randomized to receive 26-week double-dummy treatment plus calcium and vitamin D, followed by 52-week open-label treatment with the same assigned active drug. Primary endpoint was change from baseline in lumbar spine (LS) BMD at 78 weeks. Secondary and exploratory endpoints were change in BMD at the proximal femur, function, hip pain (Charnley score and 100 mm Visual Analog Scale [VAS]), quality of life (short form-36), radiology outcomes, and safety...
December 26, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28018062/non-union-fracture-neck-femur-in-a-toddler-reconstructed-by-valgus-osteotomy-a-minimally-invasive-approach
#20
Amit Sharma, Anurag Tiwari, Tarun Verma, Lalit Maini
BACKGROUND: Non-union is one of the devastating complications of fracture neck of femur. Though a very rarely encountered entity in a toddler (1-3 years paediatric age group), non-united femoral neck fractures are reported in developing countries because of mismanagement by quacks and delay in referrals. For operative treatment, many different procedures have been described, including close/open reduction and internal fixation using K-wires, cannulated screws, fibula or nails. There is no evidence in the literature that one or other implant influences the rate of postoperative complications, such as avascular femoral head necrosis or coxa vara...
October 2016: Journal of Clinical Orthopaedics and Trauma
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