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https://www.readbyqxmd.com/read/27917354/results-of-a-hydroxyapatite-coated-femoral-stem-corail-in-chinese-a-minimum-10-year-follow-up
#1
Jianda Xu, Zikang Xie, Jianning Zhao, Yi Gao, Hong Zhao, Libo Peng, Yuxing Qu
BACKGROUND: Due to the adverse effects of cemented hip arthroplasty, uncemented stems with hydroxyapatite (HA) coating reduces these risks and enhanced integration. The concept of an extensive HA coating for the fixation of a tapered femoral stem (Corail(®)) was introduced, which can achieve durable biological fixation and preserve normal periprosthetic bone activity. Here we describe the clinical and radiological outcome in patients with the Corail(®) stem. METHODS: 92 total hip replacements in 81 patients using the Corail(®) stem were followed-up...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27915448/bone-mineral-content-and-areal-density-but-not-bone-area-predict-an-incident-fracture-risk-a-comparative-study-in-a-uk-prospective-cohort
#2
E M Curtis, N C Harvey, S D'Angelo, C S Cooper, K A Ward, P Taylor, G Pearson, C Cooper
: We studied a prospective UK cohort of women aged 20 to 80 years, assessed by dual-energy X-ray absorptiometry (DXA) at baseline. Bone mineral content (BMC) and areal bone mineral density (aBMD), but not bone area (BA), at femoral neck, lumbar spine and the whole body sites were similarly predictive of incident fractures. BACKGROUND: Low aBMD, measured by DXA, is a well-established risk factor for future fracture, but little is known about the performance characteristics of other DXA measures such as BA and BMC in fracture prediction...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27909118/the-relative-contribution-of-the-medial-and-lateral-femoral-circumflex-arteries-to-the-vascularity-of-the-head-and-neck-of-the-femur-a-quantitative-mri-based-assessment
#3
D C Dewar, L E Lazaro, C E Klinger, P K Sculco, J P Dyke, A Y Ni, D L Helfet, D G Lorich
AIMS: We aimed to quantify the relative contributions of the medial femoral circumflex artery (MFCA) and lateral femoral circumflex artery (LFCA) to the arterial supply of the head and neck of the femur. MATERIALS AND METHODS: We acquired ten cadaveric pelvises. In each of these, one hip was randomly assigned as experimental and the other as a matched control. The MFCA and LFCA were cannulated bilaterally. The hips were designated LFCA-experimental or MFCA-experimental and underwent quantitative MRI using a 2 mm slice thickness before and after injection of MRI-contrast diluted 3:1 with saline (15 ml Gd-DTPA) into either the LFCA or MFCA...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27906924/reducing-harm-from-falls
#4
Shelley Jones, Sandy Blake, Richard Hamblin, Carmela Petagna, Carl Shuker, Alan F Merry
Serious adverse event reporting from district health boards (DHBs) brought in-hospital falls to the attention of the Health Quality & Safety Commission (the Commission) when it was incepted in 2010. In 2012, responding to the large numbers reported, the Commission began planning for a three-year programme to reduce harm from falls, initially to run 2013-2015. In this article we discuss the serious consequences of falls, and the challenges and practical considerations involved in reducing the risk of falling and the rate of falls...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27902687/limb-bone-structural-proportions-and-locomotor-behavior-in-a-l-288-1-lucy
#5
Christopher B Ruff, M Loring Burgess, Richard A Ketcham, John Kappelman
While there is broad agreement that early hominins practiced some form of terrestrial bipedality, there is also evidence that arboreal behavior remained a part of the locomotor repertoire in some taxa, and that bipedal locomotion may not have been identical to that of modern humans. It has been difficult to evaluate such evidence, however, because of the possibility that early hominins retained primitive traits (such as relatively long upper limbs) of little contemporaneous adaptive significance. Here we examine bone structural properties of the femur and humerus in the Australopithecus afarensis A...
2016: PloS One
https://www.readbyqxmd.com/read/27896274/halo-gravity-traction-is-associated-with-reduced-bone-mineral-density-of-patients-with-severe-kyphoscoliosis
#6
Xiao Han, Weixiang Sun, Yong Qiu, Leilei Xu, Shifu Sha, Benlong Shi, Huang Yan, Zhen Liu, Zezhang Zhu
Background. Halo gravity traction (HGT) is one of the most commonly used perioperative techniques for the treatment of severe kyphoscoliosis. This study was to explore the influence of HGT on the BMD of these patients. Methods. Patients with severe kyphoscoliosis treated by preoperative HGT for at least 2 months were included. Patients' BMD were assessed by dual-energy X-ray absorptiometry at lumbar spine (LS, L2-L4) and femur neck (FN) of the nondominant side. The weight and duration of traction, as well as baseline characteristics, were recorded...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27895366/intra-operative-implantation-errors-during-austin-moore-hemiarthroplasty
#7
Zohaib Gulzar Naqvi, Javed Ali Markhand, Syed Kamran Ahmed, Amin Chinoy, Mansoor Ali Khan
Austin Moore hemiarthroplasty is an established treatment in elderly patients with neck of femur fractures. Being commonly performed, it is also associated with several technical errors of implantation which results in complications and failure requiring revision surgery. This retrospective pre- and post-operative radiographic study to determine the frequency of technical errors was conducted at the Indus Hospital, Karachi, and comprised data of 50 patients who underwent Austin Moore hemiarthroplasty between January and November 2016...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894941/one-year-of-abaloparatide-a-selective-peptide-activator-of-the-pth1-receptor-increased-bone-mass-and-strength-in-ovariectomized-rats
#8
Aurore Varela, Luc Chouinard, Elisabeth Lesage, Robert Guldberg, Susan Y Smith, Paul J Kostenuik, Gary Hattersley
Abaloparatide is a novel 34 amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor 1 (PTHR1) signaling pathway. The effects of 12months of abaloparatide treatment on bone mass, bone strength and bone quality was assessed in osteopenic ovariectomized (OVX) rats. SD rats were subjected to OVX or sham surgery at 6months of age and left untreated for 3months to allow OVX-induced bone loss. Eighteen OVX rats were sacrificed after this bone depletion period, and the remaining OVX rats received daily s...
November 25, 2016: Bone
https://www.readbyqxmd.com/read/27889047/sex-differences-in-the-association-between-stroke-and-bone-mineral-density-in-elderly-koreans-the-korean-national-health-and-nutrition-examination-survey-2008-2010
#9
Ji Eun Lee, Hye-Rim Jeon, Jung Keun Park, Kyung-Do Han, Ji-Hyun Kim, Jinnie Yoon, Seok-Won Park, Yang-Hyun Kim, Kyung-Hwan Cho
OBJECTIVES: The aim of this study was to investigate whether osteoporosis is more prevalent in elderly Korean people who have had a stroke and whether the association differs by sex. STUDY DESIGN: A total of 3806 elderly subjects (1951 men and 1855 women) from the Korea National Health and Nutrition Examination Survey were included in this study. Stroke history was determined by self-administered questionnaire. Bone mineral density (BMD) was measured at the lumbar spine, total hip, and neck of the femur using dual-energy X-ray absorptiometry...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27871812/effects-of-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-on-bone-mineral-density-and-marrow-adipose-tissue
#10
Miriam A Bredella, Logan B Greenblatt, Alireza Eajazi, Martin Torriani, Elaine W Yu
Bariatric surgery is associated with bone loss but skeletal consequences may differ between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed bariatric procedures. Furthermore, severe weight loss is associated with high marrow adipose tissue (MAT); however, MAT is also increased in visceral adiposity. The purpose of our study was to determine the effects of RYGB and SG on BMD and MAT. We hypothesized that both bariatric procedures would lead to a decrease in BMD and MAT...
November 15, 2016: Bone
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#11
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27865001/romosozumab-improves-bone-mass-and-strength-while-maintaining-bone-quality-in-ovariectomized-cynomolgus-monkeys
#12
Michael S Ominsky, Steven K Boyd, Aurore Varela, Jacquelin Jolette, Melanie Felx, Nancy Doyle, Nacera Mellal, Susan Y Smith, Kathrin Locher, Sabina Buntich, Ian Pyrah, Rogely W Boyce
Romosozumab (Romo), a humanized sclerostin antibody, is a bone-forming agent under development for treatment of osteoporosis. To examine the effects of Romo on bone quality, mature cynomolgus monkeys (cynos) were treated 4 months post-ovariectomy (OVX) with vehicle, 3, or 30 mg/kg Romo for 12 months, or with 30 mg/kg Romo for 6 months followed by vehicle for 6 months (30/0). Serum bone formation markers were increased by Romo during the first 6 months, corresponding to increased cancellous, endocortical, and periosteal bone formation in rib and iliac biopsies at months 3 and 6...
November 10, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27858121/trends-in-hip-fracture-rates-in-taiwan-a-nationwide-study-from-1996-to-2010
#13
T Y Wu, H Y Hu, S Y Lin, W C Chie, R S Yang, C K Liaw
: There was an initial increase and a later decrease in hip fracture rates in Taiwan between 1996 and 2010 (457.9 to 390.0 fractures per 100,000 people per year). Mortality rates decreased but re-emerged later (2.26 to 1.91 deaths per 100 hip fracture admissions). The turning point for change in trends was 2003. INTRODUCTION: Fractures of the proximal femur remain a major cause of mortality and morbidity. We aimed to examine recent trends in hip fracture rates, in-hospital mortality rates, and length of hospital stay (LOS) due to hip fractures in people aged 55 and over in Taiwan...
November 17, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27857920/effectiveness-of-osteoporosis-drug-in-postmenopausal-women-with-spinal-compression-fracture-combined-consecutive-therapy-of-teriparatide-and-raloxifene-versus-bisphosphonate-single
#14
Chang Jin Shin, Sion Kim, Chun Sik Choi, Hyun Chul Shin, Young Joon Kwon
OBJECTIVE: Bisphosphonate, a typical bone resorption inhibitor, is an important first-line drug for treating osteoporosis. Recent studies show a novel paradigm in stimulating bone formation. Teriparatide, which is composed of recombinant human parathyroid hormone, stimulates osteoblasts and induces bone regeneration. Bone mineral density (BMD) that was used before and after the treatment with anti-osteoporosis drug was compared for the effectiveness in therapy between a combination of teriparatide and selective estrogen receptor modulator (SERM), and bisphosphonate...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27855776/periprosthetic-bone-density-changes-after-minihip-tm-cementless-femoral-short-stem-one-year-results-of-dual-energy-x-ray-absorptiometry-study
#15
Ahmet Ercan, Sherif M Sokkar, Gebhard Schmid, Timm J Filler, Ashraf Abdelkafy, Joerg Jerosch
INTRODUCTION: The purpose of the current study was to investigate the reaction of the femur to the implantation of the MiniHip(TM) in terms of: (1) bone density change during one year; (2) correlations between stem length, CCD (caput-collum-diaphyseal), femoral offset, T-value, and bone density; (3) other co-variables that influence the change of bone density. PATIENTS AND METHODS: MiniHip(TM) implant was performed for 62 patients. The age range of the patients who underwent treatment was 25-78 years...
2016: SICOT-J
https://www.readbyqxmd.com/read/27855207/association-of-serum-osteoprotegerin-levels-with-bone-loss-in-chronic-kidney-disease-insights-from-the-know-ckd-study
#16
Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Seung Hyeok Han, Kyu Hun Choi, Joongyub Lee, Dong Wan Chae, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim
Osteoprotegerin, a potent osteoclast activation inhibitor, decreases bone resorption and positively affects bone mineral density. This study examined the association between serum osteoprotegerin levels and bone loss in patients with chronic kidney disease, a condition associated with increased risk of mineral and bone disorders. The bone mineral densities of the lumbar spine, total hip, and femur neck were assessed by dual-energy X-ray absorptiometry; serum osteoprotegerin levels were measured at baseline for 1,423 patients enrolled in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)...
2016: PloS One
https://www.readbyqxmd.com/read/27849387/serum-levels-of-f%C3%A4-broblast-growth-factor-23-osteoproteger%C3%A4-n-and-receptor-act%C3%A4-vator-of-nuclear-factor-kappa-b-l%C3%A4-gand-rankl-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-h-prolact%C3%A4-noma
#17
Muyesser Sayki Arslan, Mustafa Sahin, Melia Karakose, Esra Tutal, Oya Topaloglu, Bekir Ucan, Taner Demirci, Mustafa Caliskan, Seyda Sahingol, Mustafa Ozbek, Erman Cakal
PURPOSE: The aim of this study to was to evaluate the effect of fibroblast growth factor-23 (FGF-23), osteoprotegerin (OPG), receptor activator nuclear kB ligand (RANKL), and vitamin D hormones on bone loss in patients with hyperprolactinemia due to the pituitary prolactinoma. METHODS: 46 premenopausal female patients with prolactinoma and age and sex matched healthy controls (Group 3, n=20) were recruited to this cross sectional study. Prolactinoma patients were divided into two groups as patients newly diagnosed (Group 1, n=26), and under cabergoline treatment (Group 2, n=20)...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27844134/high-mortality-in-younger-patients-with-major-osteoporotic-fractures
#18
R Ray, N D Clement, S A Aitken, M M McQueen, C M Court-Brown, S H Ralston
: Data were gathered with regard to mortality after fractures in 1006 younger patients. Results revealed that major osteoporotic fractures of the hip and humerus and drinking alcohol to excess were related to an increased risk of mortality. INTRODUCTION: Major osteoporotic fractures are known to be associated with increased mortality in older individuals. It is less clear whether this also applies to younger patients. METHODS: Date were gathered regarding patient demographics, fracture pattern, mechanism of injury, as well as smoking and alcohol intake at the time of injury in consecutive patients aged between 40 and 55 who presented to a UK trauma centre over a 12-month period...
November 14, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27843662/neck-of-femur-fracture-in-a-patient-with-a-chronic-osteomyelitis-of-the-ipsilateral-foot
#19
Anne-Carolin Döring, Anne J H Vochteloo, Kees van Doorn, Rianne M H A Huis In 't Veld, Anil Peters
This case report describes a successful two-stage treatment in a 75-year-old male with a displaced neck of femur fracture, also suffering from an active chronic osteomyelitis of the ipsilateral calcaneus. In our case, a below-knee amputation was performed first, followed by total hip arthroplasty two weeks later. At 15-month follow-up, full recovery of the prefracture level of activities of daily living without significant impairment was obtained. Only a few cases of total hip arthroplasty in amputees have been published, but the indication for surgery was mainly traumatic or advanced osteoarthritis...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27833587/a-candidate-gene-association-study-of-bone-mineral-density-in-an-iranian-population
#20
Seyed Alireza Dastgheib, Alison Gartland, Seyed Mohammad Bagher Tabei, Gholamhossein Ranjbar Omrani, Marion Dawn Teare
The genetic epidemiology of variation in bone mineral density (BMD) and osteoporosis is not well studied in Iranian populations and needs more research. We report a candidate gene association study of BMD variation in a healthy cross-sectional study of 501 males and females sampled from the Iranian Multi-Centre Osteoporosis Study, Shiraz, Iran. We selected to study the association with 21 single nucleotide polymorphisms (SNPs) located in the 7 candidate genes LRP5, RANK, RANKL, OPG, P2RX7, VDR, and ESR1. BMD was measured at the three sites L2-L4, neck of femur, and total hip...
2016: Frontiers in Endocrinology
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