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C 2657

Dominic H Moon, Ram S Basak, Ronald C Chen
BACKGROUND: Twelve percent of newly diagnosed prostate cancers in the United States are node-positive. In a setting of disparate treatment guideline recommendations for node-positive disease, this study describes the treatment patterns for clinical node-positive (cN(+)) and pathologic node-positive (pN(+)) patients across the United States. MATERIALS AND METHODS: Using the National Cancer Data Base, men diagnosed with cN(+) or pN(+) disease were identified from 2006 to 2011. For each cohort, the proportion of patients who received radiotherapy (RT), androgen deprivation therapy (ADT), and other treatments was analyzed...
August 24, 2017: Clinical Genitourinary Cancer
Yuichiro Yano, Jared P Reis, Yacob G Tedla, David C Goff, David R Jacobs, Stephen Sidney, Hongyan Ning, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones
Importance: Data are sparse regarding which blood pressure (BP) components in young adulthood optimally determine cardiovascular disease (CVD) by middle age. Objectives: To assess which BP components best determine incident CVD events in young adults and determine whether these associations vary by race and age at BP measurement. Design, Setting, and Participants: Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, this study assessed the longitudinal race-stratified associations between BP and cardiovascular outcomes...
April 1, 2017: JAMA Cardiology
George N Magrath, Emil Anthony T Say, Kareem Sioufi, Sandor Ferenczy, Wasim A Samara, Carol L Shields
PURPOSE: To evaluate the variability in foveal avascular zone (FAZ) and capillary density measurements on optical coherence tomography angiography using Optovue RTVue XR Avanti (OA) (Optovue) and Zeiss Cirrus HD-OCT 5000 (ZC) (Carl Zeiss Meditec). METHODS: In this prospective, comparative case series, parafoveal (3 × 3 mm) optical coherence tomography angiography scans were obtained on healthy volunteers using both the Avanti and Cirrus. The FAZ area and capillary density at the level of both the superficial and deep capillary plexus were measured automatically using the built-in ReVue software (Optovue) with the Avanti as well as manually using ImageJ (National Institutes of Health) with both machines...
November 2017: Retina
Zatollah Asemi, Mansooreh Samimi, Mehrnush Amiri Siavashani, Maryam Mazloomi, Zohreh Tabassi, Maryam Karamali, Mehri Jamilian, Ahmad Esmaillzadeh
BACKGROUND: Pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. The current study was designed to evaluate the effects of calcium plus Vitamin D administration on metabolic status and pregnancy outcomes in healthy pregnant women. METHODS: This randomized double-blind placebo-controlled clinical trial was performed among 42 pregnant women aged 18-40 years who were at week 25 of gestation. Subjects were randomly allocated to consume either 500 mg calcium-200 IU cholecalciferol supplements (n = 21) or placebo (n = 21) for 9 weeks...
2016: International Journal of Preventive Medicine
Susana Igreja, Luka A Clarke, Hugo M Botelho, Luís Marques, Margarida D Amaral
Cystic fibrosis (CF), the most common life-threatening genetic disease in Caucasians, is caused by ∼2,000 different mutations in the CF transmembrane conductance regulator (CFTR) gene. A significant fraction of these (∼13%) affect pre-mRNA splicing for which novel therapies have been somewhat neglected. We have previously described the effect of the CFTR splicing mutation c.2657+5G>A in IVS16, showing that it originates transcripts lacking exon 16 as well as wild-type transcripts. Here, we tested an RNA-based antisense oligonucleotide (AON) strategy to correct the aberrant splicing caused by this mutation...
February 2016: Human Mutation
R I Tjon-Kon-Fat, A J Bensdorp, P M M Bossuyt, C Koks, G J E Oosterhuis, A Hoek, P Hompes, F J Broekmans, H R Verhoeve, J P de Bruin, R van Golde, S Repping, B J Cohlen, M D A Lambers, P F van Bommel, E Slappendel, D Perquin, J Smeenk, M J Pelinck, J Gianotten, D A Hoozemans, J W M Maas, H Groen, M J C Eijkemans, F van der Veen, B W J Mol, M van Wely
STUDY QUESTION: What is the cost-effectiveness of in vitro fertilization (IVF) with conventional ovarian stimulation, single embryo transfer (SET) and subsequent cryocycles or IVF in a modified natural cycle (MNC) compared with intrauterine insemination with controlled ovarian hyperstimulation (IUI-COH) as a first-line treatment in couples with unexplained subfertility and an unfavourable prognosis on natural conception?. SUMMARY ANSWER: Both IVF strategies are significantly more expensive when compared with IUI-COH, without being significantly more effective...
October 2015: Human Reproduction
Katharina König, Martin Peifer, Jana Fassunke, Michaela A Ihle, Helen Künstlinger, Carina Heydt, Katrin Stamm, Frank Ueckeroth, Claudia Vollbrecht, Marc Bos, Masyar Gardizi, Matthias Scheffler, Lucia Nogova, Frauke Leenders, Kerstin Albus, Lydia Meder, Kerstin Becker, Alexandra Florin, Ursula Rommerscheidt-Fuss, Janine Altmüller, Michael Kloth, Peter Nürnberg, Thomas Henkel, Sven-Ernö Bikár, Martin L Sos, William J Geese, Lewis Strauss, Yon-Dschun Ko, Ulrich Gerigk, Margarete Odenthal, Thomas Zander, Jürgen Wolf, Sabine Merkelbach-Bruse, Reinhard Buettner, Lukas C Heukamp
INTRODUCTION: The Network Genomic Medicine Lung Cancer was set up to rapidly translate scientific advances into early clinical trials of targeted therapies in lung cancer performing molecular analyses of more than 3500 patients annually. Because sequential analysis of the relevant driver mutations on fixated samples is challenging in terms of workload, tissue availability, and cost, we established multiplex parallel sequencing in routine diagnostics. The aim was to analyze all therapeutically relevant mutations in lung cancer samples in a high-throughput fashion while significantly reducing turnaround time and amount of input DNA compared with conventional dideoxy sequencing of single polymerase chain reaction amplicons...
July 2015: Journal of Thoracic Oncology
A Perusco, C Gamba, P Galarza, F Rojas, A Kalapodis, A Onofri, C Soratti, G Piccinelli
BACKGROUND: Hematopoietic progenitor cell transplantation is considered a standard-of-care treatment for defined hematological and non-hematological conditions affecting bone marrow-derived cells. METHODS: Patients and potential donors are HLA typed for their HLA-A, -B, -C, -DRB1, and -DQB1 alleles. The best allogeneic donor is one for which each allele matches the patient at HLA-A, -B, -C, and -DRB1 (8/8). For patients with no related donor, the transplant physician will start a search for unrelated donors...
November 2014: Transplantation Proceedings
Neeraj Sharma, Patrick R Sosnay, Anabela S Ramalho, Christopher Douville, Arianna Franca, Laura B Gottschalk, Jeenah Park, Melissa Lee, Briana Vecchio-Pagan, Karen S Raraigh, Margarida D Amaral, Rachel Karchin, Garry R Cutting
Assessment of the functional consequences of variants near splice sites is a major challenge in the diagnostic laboratory. To address this issue, we created expression minigenes (EMGs) to determine the RNA and protein products generated by splice site variants (n = 10) implicated in cystic fibrosis (CF). Experimental results were compared with the splicing predictions of eight in silico tools. EMGs containing the full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) coding sequence and flanking intron sequences generated wild-type transcript and fully processed protein in Human Embryonic Kidney (HEK293) and CF bronchial epithelial (CFBE41o-) cells...
October 2014: Human Mutation
Victor C Kok, Chien-Kuan Lee, Jorng-Tzong Horng, Che-Chen Lin, Fung-Chang Sung
INTRODUCTION: Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real-world etiology or mechanisms of the non-hereditary non-AIHA from a nationwide population-based administrative claim database in Taiwan...
2014: Clinical Medicine Insights. Pathology
Laia Masvidal, Susana Igreja, Maria D Ramos, Antoni Alvarez, Javier de Gracia, Anabela Ramalho, Margarida D Amaral, Sara Larriba, Teresa Casals
The major purpose of the present study was to quantify correctly spliced CFTR transcripts in human nasal epithelial cells from cystic fibrosis (CF) patients carrying the splicing mutations c.580-1G>T (712-1G>T) and c.2657+5G>A (2789+5G>A) and to assess the applicability of this model in CFTR therapeutic approaches. We performed the relative quantification of CFTR mRNA by reverse transcription quantitative PCR (RT-qPCR) of these splicing mutations in four groups (wild type, CF-F508del controls, CF patients and CF carriers) of individuals...
June 2014: European Journal of Human Genetics: EJHG
Rebecca Troisi, Marianne Hyer, Elizabeth E Hatch, Linda Titus-Ernstoff, Julie R Palmer, William C Strohsnitter, Arthur L Herbst, Ervin Adam, Robert N Hoover
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking. METHODS: We estimated hazard ratios and their associated 95% confidence intervals for the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis, and related conditions among 5590 female and 2657 male offspring followed from 1994 through 2006, adjusted for birth year, cohort, sex, body mass index, smoking status, alcohol use, education, and number of general physical examinations in the past 5 years...
May 2013: Epidemiology
Vaida Arcisauskaite, Stefan Knecht, Stephan P A Sauer, Lars Hemmingsen
We examine the performance of Density Functional Theory (DFT) approaches based on the Zeroth-Order Regular Approximation (ZORA) Hamiltonian (with and without inclusion of spin-orbit coupling) for predictions of electric field gradients (EFGs) at the heavy atom Hg nucleus. This is achieved by comparing with benchmark DFT and CCSD-T data (Arcisauskaite et al., Phys. Chem. Chem. Phys., 2012, 14, 2651-2657) obtained from 4-component Dirac-Coulomb Hamiltonian calculations. The investigated set of molecules comprises linear HgL(2) (L = Cl, Br, I, CH(3)) and bent HgCl(2) mercury compounds as well as the trigonal planar [HgCl(3)](-) system...
December 14, 2012: Physical Chemistry Chemical Physics: PCCP
Kerry N L Avery, Chris Metcalfe, Kavita Vedhara, J Athene Lane, Michael Davis, David E Neal, Freddie C Hamdy, Jenny L Donovan, Jane M Blazeby
BACKGROUND: Little is known about factors influencing men's decisions to undergo screening and diagnostic tests for prostate cancer (PCa). OBJECTIVE: Identify predictors of attendance for prostate-specific antigen (PSA) testing and prostate biopsy. DESIGN, SETTING, AND PARTICIPANTS: Literature searches and interviews with men undergoing PSA testing and prostate biopsy formed the basis of a self-report questionnaire designed to identify predictors of health behaviour, which was completed by men eligible for PSA invitation and prostate biopsy...
October 2012: European Urology
Inusha Panigrahi, Pankaj C Vaidya, Deepak Bansal, Ram K Marwaha
Deferasirox (DFX) is a relatively new iron chelator approved by the US Food and Drug Administration for treatment of children >2 years of age. Prospective studies in Asian Indian children are limited. The β-thalassemia patients receiving regular transfusions in the thalassemia ward of an advanced pediatric center were included in this study. Monitoring of side effects was carried out by assessing monthly transaminases and serum creatinine levels. Hemoglobin levels were determined before blood transfusion...
January 2012: Journal of Pediatric Hematology/oncology
Radhey S Srivastava, Carlos F Gonzales, Frank R Fronczek
The title mol-ecule, [RuCl(2)(C(4)H(8)OS)(3)(H(2)O)], is the isomer with the two chloride ligands cis and the three S-coordinated tetra-methyl-ene sulfoxide ligands facial relative to the Ru(II) center. The Ru-Cl distances are 2.4161 (7) and 2.4317 (7) Å, the Ru-O distance is 2.1540 (19) Å, and the Ru-S distances are in the range 2.2254 (8)-2.2657 (7) Å, with the shortest being that trans to the aqua ligand. The coordinated water mol-ecule forms inter-molecular hydrogen bonds with Cl and sulfoxide O atoms...
2009: Acta Crystallographica. Section E, Structure Reports Online
Min Min Zhao, Ping Ping Shi
The crystal structure of the title compound, (C(6)H(7)FN)(2)[CuCl(4)], consists of parallel two-dimensional perovskite-type layers of corner-sharing CuCl(6) octa-hedra. These are bonded together via N-H⋯Cl hydrogen bonds from the 4-fluoro-anilinium chains, which are almost perpendicular to the layers. The CuCl(4) dianions have two short Cu-Cl bonds [2.2657 (15) and 2.2884 (13) Å] and two longer bonds [2.8868 (15) Å], giving highly Jahn-Teller-distorted CuCl(6) octa-hedra. The Cu atoms are situated on crystallographic centers of inversion...
2010: Acta Crystallographica. Section E, Structure Reports Online
Jaime Ortiz, Juan Vivanco, Paula Jiménez, Moisés Leiva, Leslie Ramírez, Andrés Bustamante
Some nutritional components of the edible seaweeds Cryptonemia obovata and Rhodymenia corallina were determined. The amino acid content ranged from 1.0 +/- 0.3 to 4174.2 +/- 14.2 mg 100 g(-1) dry wt in C. obovata and between 0.9 +/- 0.3 and 2657.0 +/- 13.5 mg 100 g(-1) dry wt in R. corallina. The most abundant fatty acid in C. obovata was palmitic acid, reaching a value of 36.5 +/- 0.2%, while in Rhodymenia corallina the main fatty acid was oleic acid, reaching a value of 24.7 +/- 0.07%. Both seaweeds showed an important content of EPA (C20:5omega3)...
October 2010: Natural Product Communications
Jiangyue Zhang, Narayan Yoganandan, Frank A Pintar, Yabo Guan, Barry Shender, Glenn Paskoff, Purushottam Laud
Postmortem preservation conditions may be one of factors contributing to wide material property variations in brain tissues in literature. The objective of present study was to determine the effects of preservation temperatures on high strain-rate material properties of brain tissues using the split Hopkinson pressure bar (SHPB). Porcine brains were harvested immediately after sacrifice, sliced into 2 mm thickness, preserved in ice cold (group A, 10 samples) and 37°C (group B, 9 samples) saline solution and warmed to 37°C just prior to the test...
February 3, 2011: Journal of Biomechanics
Fiona C Bull, Tahlia S Maslin, Timothy Armstrong
PURPOSE: Instruments to assess physical activity are needed for (inter)national surveillance systems and comparison. METHODS: Male and female adults were recruited from diverse sociocultural, educational and economic backgrounds in 9 countries (total n = 2657). GPAQ and the International Physical Activity Questionnaire (IPAQ) were administered on at least 2 occasions. Eight countries assessed criterion validity using an objective measure (pedometer or accelerometer) over 7 days...
November 2009: Journal of Physical Activity & Health
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