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https://www.readbyqxmd.com/read/29471066/a-pharmacokinetic-study-on-lapatinib-in-type-2-diabetic-rats
#1
Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Agnieszka Klupczynska, Szymon Plewa, Tomasz Grabowski, Anna Wolc, Marta Moch, Zenon J Kokot, Edmund Grześkowiak
BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disorder which affects the function of numerous tissues and alters the pharmacokinetic parameters of many drugs. As many oncological patients are diabetics, it is important to determine the influence of this chronic disease on the pharmacokinetics (PK) of anticancer drugs. Lapatinib is a tyrosine kinase inhibitor (TKI), approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer...
September 18, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29459428/attenuation-of-nk-cells-facilitates-mammary-tumor-growth-in-stz-induced-diabetes-in-mice
#2
Nevena Gajovic, Milena Jurisevic, Jelena Pantic, Gordana D Radosavljevic, Nebojsa Arsenijevic, Miodrag Lukic, Ivan Jovanovic
Diabetic patients have higher incidence and mortality of cancer. Recent study revealed that hyperglycemia-induced oxidative stress is involved in the acceleration of tumor metastasis. We used model of high dose streptozotocin-induced diabetes to investigate its effect on tumor growth and modulation of antitumor immune response of 4T1 murine breast cancer in BALB/c mice. Diabetes accelerated tumor appearance, growth and weight, which was associated with decreased NK cells cytotoxicity against 4T1 tumor cells in vitro...
February 19, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29454147/factors-associated-with-malignancy-in-hysteroscopically-resected-endometrial-polyps-a-systematic-review-and-meta-analysis
#3
Lizandra M Paravidine Sasaki, Keitty R C Andrade, Ana Claudia Morais Godoy Figueiredo, Miriam da S Wanderley, Maurício G Pereira
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#4
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29434959/retrospective-observational-cohort-study-on-cosmetic-outcome-of-using-ti-ni-memory-alloy-wire-for-intradermal-suture-following-mastectomy-in-patients-with-breast-cancer
#5
Gang Li, Sida Qin, Xin Sun, Jiansheng Wang, Yunfeng Zhang, Jia Zhang, Jing Zhang, Shou-Ching Tang, Hong Ren
The method of suturing for incisions is crucial for the comprehensive treatment of clinical patients with breast cancer. Suturing is considered a major part of post-surgical recovery and may serve as a marker for evaluation of surgical outcome. The present study aimed to establish an effective means of suturing for patients who received modified radical surgery that helps to improve the cosmetic outcome of the incision. Enrolled patients were divided into an active and a control group. Ti-Ni memory alloy wire for intradermal suture in the active group and silk for interruption suture in the control group were applied to assess the different prognosis-associated factors...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434658/healthy-living-and-cancer-evidence-from-uk-biobank
#6
Peter C Elwood, Alex Whitmarsh, John Gallacher, Anthony Bayer, Richard Adams, Luke Heslop, Janet Pickering, Gareth Morgan, Julieta Galante, Sunil Dolwani, Marcus Longley, Zoe E Roberts
Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. Objective: A healthy lifestyle has been described as 'better than any pill, and no side effects [5]. We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29427202/predictors-of-vasomotor-symptoms-among-breast-cancer-survivors
#7
Katherine W Reeves, Michael Pennell, Randi E Foraker, Carolyn J Crandall, Marcia Stefanick, Electra D Paskett
PURPOSE: Vasomotor symptoms (VMS) are a common side effect of breast cancer treatment, yet modifiable factors that may predict VMS among breast cancer survivors are unknown. METHODS: We estimated multivariable-adjusted odds ratios and 95% confidence intervals (aOR, 95% CI) for predictors of VMS among 3595 breast cancer survivors enrolled in the Life and Longevity after Cancer (LILAC) study, an ancillary study of the Women's Health Initiative (WHI). RESULTS: VMS post-diagnosis were reported by 790 (22...
February 9, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29423760/non-communicable-chronic-diseases-and-timely-breast-cancer-screening-among-women-of-the-eastern-caribbean-health-outcomes-research-network-echorn-cohort-study
#8
K H Wang, T A Thompson, D Galusha, H Friedman, C M Nazario, M Nunez, R G Maharaj, O P Adams, M Nunez-Smith
PURPOSE: The Caribbean population faces a growing burden of multiple non-communicable chronic diseases (NCDs). Breast cancer is the leading cause of cancer death for women in the Caribbean. Given the substantial burden of NCDs across the region, cancer prevention and control strategies may need to be specifically tailored for people with multiple co-morbidities. Preventive screening, such as timely mammography, is essential but may be either facilitated or hampered by chronic disease control...
February 8, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29421703/design-synthesis-and-in-vitro-%C3%AE-glucosidase-inhibition-of-novel-dihydropyrano-3-2-c-quinoline-derivatives-as-potential-anti-diabetic-agents
#9
Hamideh Nikookar, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad Ali Faramarzi, Parviz Rashidi Ranjbar, Mohammad Mahdavi, Bagher Larijani
A novel series of dihydropyrano[3,2-c]quinoline derivatives 6a-q were synthesized and evaluated for their in vitro α-glucosidase inhibitory activities. All newly synthesized compounds displayed potent α-glucosidase inhibitory activity in the range of 10.3 ± 0.3 µM-172.5 ± 0.8 µM against the yeast α-glucosidase enzyme when compared to the standard drug acarbose (IC50 = 750.0 ± 1.5 µM). Among these compounds, compounds 6e and 6d displayed the most potent α-glucosidase inhibitory activity (IC50 = 10...
February 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29421309/female-offspring-birth-weight-is-associated-with-body-mass-index-waist-circumference-and-metabolic-syndrome-in-latin-american-women-at-10-years-postpartum
#10
Natalie Mueller, Maria-Luisa Garmendia, Marcela Reyes, Camila Corválan, Ana Pereira, Ricardo Uauy
AIMS: We aimed to assess whether female offspring birth weight (BW) is associated with anthropometric and metabolic outcomes in Chilean mothers at 10-years postpartum. METHODS: We assessed data from 396 Chilean mother-daughter pairs participating in the longitudinal Chilean Growth and Obesity Cohort (GOCS) and Determinants of Breast Cancer Risk (DERCAM) studies. Multivariate linear and logistic regression models were performed to associate female offspring BW with maternal Body Mass Index (BMI), waist circumference, type 2 diabetes mellitus, metabolic syndrome and its components at 10-years postpartum...
February 5, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29416762/metformin-synergistically-suppress-tumor-growth-with-doxorubicin-and-reverse-drug-resistance-by-inhibiting-the-expression-and-function-of-p-glycoprotein-in-mcf7-adr-cells-and-xenograft-models
#11
Ying Li, Meng Wang, Pei Zhi, Jian You, Jian-Qing Gao
Acquired resistance to chemo-drugs remains a major obstacle to successful cancer therapy. Metformin, a well-documented drug for treating type II diabetes, was recently proposed as a novel agent for tumor treatment. In this study, we found that metformin suppressed MCF7/ADR, a doxorubicin-resistant breast cancer cell line, and acted synergistically with doxorubicin by reversing drug-resistant phenotypes both in vitro and in vivo. Metformin alone dose-dependently inhibited tumor growth, especially the stressful tumor microenvironment of glucose deficiency, and the cytotoxicity of metformin was markedly enhanced by increasing ROS production and ATP depletion...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29410239/what-the-oncologist-can-learn-from-diabetes-studies-epidemiology-prevention-management-cure
#12
REVIEW
Adriana Albini, Marco Gallo
Notwithstanding massive efforts and investment in improving cancer therapy, the limited progress made in reducing overall mortality has mostly been achieved through early diagnosis. Mortality rates for cardiovascular disease are in decline, a success attributable in large part to an active prevention approach coupled with identification of risk factors and biomarkers. Promising natural and synthetic molecules including numerous flavonoids have the potential to be used in diabetes care and in prevention of cardiovascular pathologies...
February 1, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29397734/unique-features-of-metformin-a-combined-experimental-theoretical-and-simulation-study-of-its-structure-dynamics-and-interaction-energetics-with-dna-grooves
#13
Sayantan Mondal, Rudra Narayan Samajdar, Saumyak Mukherjee, Aninda Jiban Bhattacharyya, Biman Bagchi
There are certain small molecules that exhibit extraordinarily diverse biological activities. Metformin is one of them. It is widely used as anti-diabetic drug for type-two diabetes. Recent evidences of its role in anti-tumour activities and increasing the survival rates of cancer patients (namely colorectal, breast, pancreas and prostate cancer) are emerging. However, theoretical studies of structure and dynamics of metformin have not yet been fully explored. In this work, we investigate the characteristic structural and dynamical features of three mono-protonated forms of metformin hydrochloride with the help of experiments, quantum chemical calculations and atomistic molecular dynamics simulations...
February 3, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29384865/postoperative-outcomes-of-breast-reconstruction-after-mastectomy-a-retrospective-study
#14
Qinghong Qin, Qixing Tan, Bin Lian, Qinguo Mo, Zhen Huang, Changyuan Wei
Breast reconstruction after mastectomy plays an active role in improving the quality-of-life (QoL) and alleviating the psychological trauma of breast cancer patients, and has become an indispensable part of the comprehensive treatment in breast cancer. However, compared with mastectomy alone, breast reconstruction also increase operative complications. The surgical, oncological outcomes, and cosmetic effect of breast reconstruction remains to be evaluated. Data for patients with breast cancer who underwent breast reconstruction after mastectomy from February 2009 to November 2015 in our hospital were retrospectively analyzed, with a median follow-up time of 44 months...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383194/combined-effect-of-obesity-and-diabetes-on-early-breast-cancer-outcome-a-prospective-observational-study
#15
Giuseppe Buono, Anna Crispo, Mario Giuliano, Carmine De Angelis, Francesco Schettini, Valeria Forestieri, Rossella Lauria, Matilde Pensabene, Michelino De Laurentiis, Livia Silvia Adriana Augustin, Alfonso Amore, Massimiliano D'Aiuto, Raffaele Tortoriello, Antonello Accurso, Ernesta Cavalcanti, Gerardo Botti, Maurizio Montella, Sabino De Placido, Grazia Arpino
Background: Previous studies suggested that obesity and diabetes were correlated with breast cancer outcome. The aim of the present study was to investigate the prognostic effect of obesity and diabetes on the outcome of early breast cancer patients. Materials and Methods: Overall, 841 early breast cancer patients were prospectively enrolled between January 2009 and December 2013. Study population was divided into four groups: (1) patients without obesity or diabetes; (2) patients with only diabetes; (3) patients with only obesity; and (4) patients with both diabetes and obesity...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29376219/selenium-for-preventing-cancer
#16
REVIEW
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29371278/association-between-body-mass-index-and-obesity-related-cancer-risk-in-men-and-women-with-type-2-diabetes-in-primary-care-in-the-netherlands-a-cohort-study-zodiac-56
#17
Steven H Hendriks, Dennis Schrijnders, Kornelis Jj van Hateren, Klaas H Groenier, Sabine Siesling, Angela H E M Maas, Gijs W D Landman, Henk J G Bilo, N Kleefstra
OBJECTIVE: To investigate the relationship between body mass index (BMI) and obesity-related cancers in men and women with type 2 diabetes (T2D). DESIGN: Observational cohort study. SETTING: Primary care. PARTICIPANTS: A total of 52 044 patients with T2D who participated in the ZODIAC (Zwolle Outpatient Diabetes project Integrating Available Care) study between 1998 and 2012 was included (49% women). A dataset of these patients was linked to available information of the Netherlands Cancer Registry to obtain data on cancer incidents...
January 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29370205/sex-differences-in-obesity-related-cancer-incidence-in-relation-to-type-2-diabetes-diagnosis-zodiac-49
#18
Dennis Schrijnders, Steven H Hendriks, Nanne Kleefstra, Pauline A J Vissers, Jeffrey A Johnson, Geertruida H de Bock, Henk J G Bilo, Gijs W D Landman
BACKGROUND: Diabetes and obesity seem to be partly overlapping risk factors for the development of obesity-related cancer (mainly breast, prostate and colorectal cancer) in patients with type 2 diabetes (T2DM). In the general population, women have a lower risk for obesity-related cancer compared to men. Previous studies involving cardiovascular disease have shown that T2DM eliminates a female advantage of lower CVD risk in the general population compared to men. It is unclear whether the same could be true for obesity-related cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29369158/the-growing-burden-of-non-communicable-disease-among-persons-living-with-hiv-in-zimbabwe
#19
Mikaela Smit, Jack Olney, Nathan P Ford, Marco Vitoria, Simon Gregson, Anna Vassall, Timothy B Hallett
OBJECTIVES: We aim to characterise the future noncommunicable disease (NCD) burden in Zimbabwe to identify future health system priorities. METHODS: We developed an individual-based multidisease model for Zimbabwe, simulating births, deaths, infection with HIV and progression, and key NCD (asthma, chronic kidney disease (CKD), depression, diabetes, hypertension, stroke, breast, cervical, colorectal, liver, oesophageal, prostate and all other cancers). The model was parameterised using national and regional surveillance and epidemiological data...
January 23, 2018: AIDS
https://www.readbyqxmd.com/read/29363790/linoleic-acid-induces-an-increased-response-to-insulin-in-mda-mb-231-breast-cancer-cells
#20
Cecilia Rodriguez-Monterrosas, Ricardo Diaz-Aragon, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Epidemiological studies and animal models suggest a link between high levels of dietary fat intake and an increased risk of developing breast cancer. Hyperinsulinemia is a feature of obesity, diabetes, and metabolic syndrome that is associated with an increased breast cancer risk. Insulin is a hormone involved in metabolic regulation of carbohydrate. However, it is also a growth factor that mediates proliferation and migration. Linoleic acid (LA) is a fatty acid that induces migration and invasion in breast cancer cells...
January 24, 2018: Journal of Cellular Biochemistry
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