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https://www.readbyqxmd.com/read/27888391/small-bowel-adenocarcinoma-in-celiac-disease-a-case-report
#1
Haitam Buaisha, Eric Nippoldt, Abdullah N Alsuwaidan, Savio Reddymasu
No abstract text is available yet for this article.
November 26, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27885681/dynamics-of-occurrence-of-refractory-coeliac-disease-and-associated-complications-over-25%C3%A2-years
#2
W Eigner, K Bashir, C Primas, L Kazemi-Shirazi, F Wrba, M Trauner, H Vogelsang
BACKGROUND: Refractory coeliac disease, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma are rare but prognostically important complications in coeliac disease. AIM: To analyse potential changes in occurrence of complicated coeliac disease over the last 25 years. METHODS: One thousand one hundred and thirty eight patients were included and evaluated based on their time of first presentation at the Medical University of Vienna, Austria...
November 25, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27859010/bevacizumab-combined-with-capecitabine-and-oxaliplatin-in-patients-with-advanced-adenocarcinoma-of-the-small-bowel-or-ampulla-of-vater-a-single-center-open-label-phase-2-study
#3
Pat Gulhati, Kanwal Raghav, Rachna T Shroff, Gauri R Varadhachary, Scott Kopetz, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert A Wolff, Michael J Overman
BACKGROUND: Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS: In this phase 2, single-arm, single-center, open-label study, patients aged ≥18 years with untreated, advanced SBA or AAC were recruited. Patients received capecitabine at a dose of 750 mg/m(2) orally twice daily on days 1 to 14, oxaliplatin at a dose of 130 mg/m(2) intravenously on day 1, and bevacizumab at a dose of 7...
November 14, 2016: Cancer
https://www.readbyqxmd.com/read/27851342/1707-small-bowel-adenocarcinoma-masked-by-a-rare-presentation-of-esophageal-rupture-and-bilateral-empyema
#4
Umair Tariq, Wael Nasser, Viral Patel
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27829602/a-case-of-crohn-s-disease-complicated-with-simultaneous-double-cancers-of-the-small-bowel
#5
Nao Obara, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Hirosuke Kuroki, Kyoko Yamada, Katsuhiko Arai, Akira Sugita, Hiroyuki Hayashi, Tsuneo Fukushima
A case of Crohn's disease complicated with simultaneous double cancers of the small bowel is reported. The patient is a 66-year-old man who had suffered from Crohn's disease for 20 years. He underwent surgery to identify the source of repeated episodes of intestinal obstruction. Two short segments of strictures and proximal dilatations were found in the distal ileum. Therefore, we performed an en bloc resection of the two stenotic sections instead of strictureplasty. Histological examination of the resected specimen revealed not only Crohn's disease but also a well-differentiated adenocarcinoma within each of the two strictures...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27784975/limited-local-extracolonic-spread-of-mucinous-appendiceal-adenocarcinoma-after-perforation-with-formation-of-a-malignant-appendix-to-sigmoid-fistula-case-report-and-literature-review
#6
Seifeldin Hakim, Mitual Amin, Mitchell S Cappell
A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum (with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27783113/small-bowel-neoplasms-enhancement-patterns-and-differentiation-using-post-contrast-multiphasic-multidetector-ct
#7
Takayoshi Shinya, Ryota Inai, Takashi Tanaka, Noriaki Akagi, Shuhei Sato, Tadashi Yoshino, Susumu Kanazawa
PURPOSE: The purpose of the present study was to analyze the enhancement patterns of small bowel neoplasms on post-contrast multiphasic multidetector CT and to assess the diagnostic capacity for differentiating five tumor types. METHODS: We performed a retrospective study of data on 92 small bowel neoplasms. The neoplasms were categorized into five groups according to pathology findings, not imaging findings (23 adenocarcinomas; 22 lymphomas; 19 metastases; 18 gastrointestinal stromal tumors [GIST]; 10 neuroendocrine tumors [NET])...
October 25, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27777768/jak2-v617f-mutation-multiple-hematologic-and-non-hematologic-processes-an-association
#8
Kenneth G Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig, Ramakrishna Battini
BACKGROUND: Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease. CASE PRESENTATION: A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. In 2009, he was diagnosed with stage IA lung adenocarcinoma and also noted to have worsening leukocytosis and thrombocytosis with peak platelet count of 1,054,000/mL)...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27759639/double-balloon-enteroscopy-in-small-bowel-diseases-eight-years-single-center-experience-in-china
#9
Wen-Guo Chen, Guo-Dong Shan, Hong Zhang, Ming Yang, Lin L, Min Yue, Guang-Wu Chen, Qing Gu, Hua-Tuo Zhu, Guo-Qiang Xu, Li-Hua Chen
The aim of the study was to evaluate the diagnostic and therapeutic value of double-balloon entoroscopy (DBE) in small bowel diseases (SBDs) in China.A retrospective review of 674 consecutive patients who underwent DBE between January 2007 and November 2015 was conducted. Patients were divided into 3 groups by age, young group (<45 years), middle-aged group (45-65 years), and elderly group (>65 years). Data were collected with regard to demographics, clinical, endoscopic findings, complications, diagnostic yield, and management...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27741381/reduced-dose-to-small-bowel-with-the-prone-position-and-a-belly-board-versus-the-supine-position-in-neoadjuvant-3d-conformal-radiotherapy-for-rectal-adenocarcinoma
#10
Rohen White, Farshad Foroudi, Joseph Sia, Mary Ann Marr, Daryl Lim Joon
INTRODUCTION: No consensus exists regarding the optimal treatment setup for neoadjuvant radiotherapy of rectal cancer using a 3D conformal (3D CRT) technique. Positioning the patient prone with a belly board aims to reduce the amount of small bowel irradiated. METHODS: Twenty-five patients with locally advanced rectal cancer underwent computed tomography (CT) planning for neoadjuvant chemoradiotherapy. Patients were simulated prone with a belly board and then in the supine position...
July 28, 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27670893/evaluation-of-prognostic-factors-and-adjuvant-chemotherapy-in-patients-with-small-bowel-adenocarcinoma-who-underwent-curative-resection
#11
Dincer Aydin, Mehmet Ali Sendur, Umut Kefeli, Olcun Umit Unal, Didem Tastekin, Murat Akyol, Eda Tanrikulu, Aydin Ciltas, Basak Bala Ustaalioglu, Mukremin Uysal, Onur Esbag, Dogan Yazilitas, Ozgur Tanrıverdi, Ahmet Bilici, Erkan Arpaci, Veli Berk, Tarkan Yetisyigit, Nuriye Yildirim Ozdemir, Ilhan Oztop, Ahmet Alacacioglu, Ozhan Aydin, Melike Ozcelik, Emre Yildirim, Nur Dinc, Mahmut Gumus
BACKGROUND: Small bowel adenocarcinoma (SBA) is a rare tumor of the gastrointestinal system with poor prognosis. Because these are rarely encountered tumors, the aim of this multicenter study was evaluation of prognostic factors and adjuvant chemotherapy in patients with curatively resected SBA. MATERIALS AND METHODS: A total of 78 patients diagnosed with curatively resected SBA were involved in the retrospective study. Forty-eight patients received 1 of 3 different chemotherapy regimens, whereas 30 patients did not receive any adjuvant treatment...
August 30, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27659145/prognosis-of-small-bowel-adenocarcinoma-in-crohn-s-disease-compares-favourably-with-de-novo-small-bowel-adenocarcinoma
#12
Nicole Wieghard, Solange Mongoue-Tchokote, J Isaac Young, Brett C Sheppard, V Liana Tsikitis
AIM: Limited data exist on Crohn's disease (CD)-associated small bowel adenocarcinoma [SBA]. A large-scale retrospective cohort study was conducted comparing the clinical features and outcome of Crohn's-associated SBA and de novo SBA. METHOD: Data for patients with small bowel adenocarcinoma was gathered from the 1992 to 2010 United States Surveillance, Epidemiology and End Results cancer registry (SEER)-Medicare linked database. 2,123 patients were identified, of whom 179 had CD-associated and 1,944 de novo SBA...
September 22, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27622191/primary-adenocarcinoma-of-an-ileostomy-in-crohn-s-disease
#13
Kevin Liu, Meena A Prasad, Amy Lo, Emanuelle Bellaguarda, Scott Strong, Stephen B Hanauer
Although Crohn's disease has been associated with an increased risk of small bowel adenocarcinoma, primary adenocarcinoma arising from an ileostomy is a complication that has been rarely documented in Crohn's disease. Chronic small bowel inflammation may lead to development of malignancy through the dysplasia-carcinoma sequence. We report a case of a 61-year-old woman with Crohn's ileocolitis diagnosed with a primary adenocarcinoma at the ileostomy with metastases to the liver 47 years after proctocolectomy, and review the literature...
July 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27620742/survival-variability-of-controls-and-definition-of-imaging-endpoints-for-longitudinal-follow-up-of-pancreatic-ductal-adenocarcinoma-in-rats
#14
Cherif Akladios, Mihaela Ignat, Didier Mutter, Marc Aprahamian
BACKGROUND: The 3Rs guideline is the gold standard for ethics in animal experimentation. Two of those rules, namely refinement and reduction, require further improvement. The objective of this study was to define pathways to better compliance with these prerequisites. Two methods which move us in this direction are: (1) using small animal imaging techniques for pancreatic ductal adenocarcinoma (PDAC) follow-up and (2) reduction of the number of control animals included in a study of PDAC progression under treatment...
September 12, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27601550/timing-is-everything-what-is-the-optimal-duration-after-chemoradiation-for-surgery-for-rectal-cancer
#15
Karyn A Goodman
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
September 6, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27546842/small-bowel-adenocarcinoma
#16
REVIEW
Thomas Aparicio, Aziz Zaanan, Florence Mary, Pauline Afchain, Sylvain Manfredi, Thomas Ronald Jeffry Evans
Small bowel adenocarcinomas (SBAs) are rare tumors, but their incidence is increasing. The most common primary location is the duodenum. Even though SBAs are more often sporadic, some diseases are risk factors. Early diagnosis of small bowel adenocarcinoma remains difficult, despite significant radiologic and endoscopic progress. After R0 surgical resection, the main prognostic factor is lymph node invasion. An international randomized trial (BALLAD [Benefit of Adjuvant Chemotherapy For Small Bowel Adenocarcinoma] study) will evaluate the benefit of adjuvant chemotherapy...
September 2016: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/27513076/metastatic-ovarian-tumors-originating-from-a-small-bowel-adenocarcinoma-a-case-report-and-brief-literature-review
#17
Junji Mitsushita, Sachiho Netsu, Koichi Suzuki, Mitsuhiro Nokubi, Akira Tanaka
Approximately 1.6% of tumors metastatic to the ovary of nongynecologic origin are from a small bowel adenocarcinoma (SBA). However, the incidence of SBA is extremely rare (0.23 cases/100,000 people), which suggests a high frequency of ovarian metastasis, although the reason is unknown. To identify the characteristics of ovarian tumor metastasis from SBA, we reviewed 72 cases reported in the English literature, including the case presented in this report. The mean age of the patients was 46.7 yr. Solitary ovarian metastasis was observed in 67% of the cases, and ovarian metastasis was accompanied by peritoneal dissemination in 33% of the cases...
August 10, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27495256/pneumatosis-intestinalis-after-gefitinib-therapy-for-pulmonary-adenocarcinoma-a-case-report
#18
Ai Maeda, Masao Nakata, Katsuhiko Shimizu, Takuro Yukawa, Shinsuke Saisho, Riki Okita
BACKGROUND: Pneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several chemotherapeutic agents and molecular targeted therapy agents are reported to be associated with PI, there have been few reports describing the association between the anti-epidermal growth factor receptor agent gefitinib, a tyrosine kinase inhibitor (TKI), and PI. The present report describes a case of PI secondary to gefitinib therapy...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27446478/small-bowel-adenocarcinoma-in-lynch-syndrome-a-case-report
#19
Ke-Kang Sun, Gang Liu, Xiaojun Shen, Xiaoyang Wu
Small bowel adenocarcinoma is part of the tumor spectrum of Lynch syndrome, which is caused by germline mutations in the mismatch repair genes. The present study describes the case of a 51-year-old man fulfilling the Amsterdam II criteria for Lynch syndrome, who had a 15-mm early-stage colorectal cancer resected endoscopically from the ascending colon. Due to upper abdominal discomfort after eating and consequent anorexia, a computed tomography scan performed 1 month later showed a tumoral mass of the upper jejunum with local lymphadenopathy...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27405958/endoscopic-detection-of-small-bowel-dysplasia-and-adenocarcinoma-in-crohn-s-disease-a-prospective-cohort-study-in-high-risk-patients
#20
M Simon, J Cosnes, J M Gornet, P Seksik, C Stefanescu, A Blain, B Pariente, S Nancey, L Vuitton, M Nachury, G D'Haens, J Filippi, S Chevret, D Laharie
BACKGROUND AND AIMS: Crohn's disease [CD] is associated with an increased risk of small bowel adenocarcinoma [SBA]. There are no recommendations on endoscopic screening of SBA in CD patients. The aim of this study was to evaluate the feasibility and value of endoscopic screening for SBA in CD patients at high-risk of SBA. METHODS: We performed an exploratory multi-centre study in a prospective cohort of CD patients at high-risk of SBA defined as long-term small bowel disease without bowel resection for the past 10 years...
July 12, 2016: Journal of Crohn's & Colitis
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