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https://www.readbyqxmd.com/read/29754035/the-elusive-small-bowel-adenocarcinoma-in-the-terminal-ileum-a-case-report
#1
Joyce Lok Gee Ma, Paul Norman Strauss
INTRODUCTION: Small bowel malignancies are rare and often present with non-specific symptoms. Because of this, diagnosis of small bowel malignancies is often missed. PRESENTATION OF CASE: 71-year-old male presented with a four-week history of right iliac fossa pain and loss of weight. Laboratory tests showed a raised C-reactive protein, but all other pathology results and tumour-associated antigens were normal. Computed tomography (CT) of the abdomen demonstrated an inflammatory mass extending laterally into the pelvic wall...
April 27, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#2
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29674013/the-tipping-point-key-oncologic-imaging-findings-resulting-in-critical-changes-in-the-management-of-malignant-tumors-of-the-gastrointestinal-tract
#3
REVIEW
Jonathan Wu, Lipika Goyal, Ryan Nipp, Jennifer Wo, Motaz Qadan, Raul N Uppot
OBJECTIVE: The purpose of this article is to review tumor staging systems for gastrointestinal tumors including pancreatic adenocarcinoma, hepatocellular carcinoma, cholangiocarcinoma, gastric adenocarcinoma, small bowel adenocarcinoma, rectal carcinoma, and anal carcinoma and identify the key imaging findings ("tipping points"), which change patient management based on changes in tumor staging. CONCLUSION: For all malignant gastrointestinal tumors, there are key imaging findings ("tipping points") including tumor size, tumor extension, lymphadenopathy, vascular invasion, and distant metastasis that dictate patient management and prognosis, based on changes in tumor stage...
January 31, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29673681/a-rare-krukenberg-tumor-arising-from-a-primary-adenocarcinoma-of-the-small-intestine
#4
Angel An-Chieh Liu, Chi-Huang Chen, Wei-Min Liu, Ching-Wen Chang
OBJECTIVE: A Krukenberg tumor is a malignancy in the ovary that metastasizes from a primary site. Here, we report a very rare case of bilateral Krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the small intestine in a 53-year-old Taiwanese woman. CASE REPORT: The patient presented with a 3-month history of abdominal distension and acid regurgitation. Gastroscopy and colonoscopy findings were negative. According to the preoperative image, we highly suspected that the small bowel mass was the primary tumor with metastatic tumors to bilateral ovarian masses...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29650418/inflammatory-bowel-disease-drastically-affects-the-prognosis-of-patients-treated-for-peritoneal-metastases-with-combined-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-multicenter-study
#5
Nassim Hammoudi, Clarisse Eveno, Jérôme Lambert, Marianne Maillet, Olivier Glehen, Diane Goere, Nelson Lourenco, Matthieu Allez, Thomas Aparicio, Marc Pocard, Jean-Marc Gornet
BACKGROUND: Complete cytoreductive surgery (CCRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a validated treatment in selected patients with peritoneal metastases (PM) of intestinal origin. There is an increased risk of Colorectal Cancer (CRC) and Small Bowel Adenocarcinoma (SBA) in Inflammatory Bowel Disease (IBD). The feasibility and benefit of that surgical approach in IBD patients is unknown. METHODS: IBD patients with operated PM complicating CRC or SBA were extracted from a French national multicenter prospective database of patients who underwent surgery for PM in HIPEC expert centers from 1995 to 2016...
March 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29624512/gastrointestinal-tract-vasculopathy-clinicopathology-and-description-of-a-possible-new-entity-with-protean-features
#6
Christine Y Louie, Michael A DiMaio, Gregory W Charville, Gerald J Berry, Teri A Longacre
Noninfectious gastrointestinal (GI) vasculopathic disorders are rare and are often overlooked in histopathologic examination or when forming differential diagnoses due to their rarity. However, involvement of the GI tract may lead to serious complications, including ischemia and perforation. Since awareness of the types of vasculopathy that may involve the GI tract is central to arriving at a correct diagnosis, we reviewed our institutional experience with GI tract vasculopathy in order to enhance diagnostic accuracy of these rare lesions...
April 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29540890/primary-jejunal-adenocarcinoma-an-unsuspected-culprit
#7
Nauman Ahmed, Hammad Naeem Rana
Primary Small bowel adenocarcinoma, a rare entity and having varied clinical presentation, makes its clinical detection a diagnostic challenge. Moreover, its true prevalence in sub-continent population has not yet been established, which makes it more difficult for its detection. We present the case of a 60 year old male who came with abdominal pain and weight loss for two years as the only symptoms. A series of tests in the two year period remained inconclusive. Later Computed tomography showed a suspicious mass at the terminal ileum...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29523759/landscape-of-tumor-mutation-load-mismatch-repair-deficiency-and-pd-l1-expression-in-a-large-patient-cohort-of-gastrointestinal-cancers
#8
Mohamed E Salem, Alberto Puccini, Axel Grothey, Derek Raghavan, Richard M Goldberg, Joanne Xiu, W Michael Korn, Benjamin A Weinberg, Jimmy J Hwang, Anthony F Shields, John L Marshall, Philip A Philip, Heinz-Josef Lenz
The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency (dMMR) status, and programmed cell death-ligand 1 (PD-L1) expression. Herein, we quantify TML, dMMR, and PD-L1 expression and determine their interrelationship in gastrointestinal cancers. Here, a total of 4,125 tumors from 14 different gastrointestinal cancer sites were studied using validated assays. Next-generation sequencing was performed on genomic DNA isolated from formalin-fixed paraffin-embedded tumor specimens using the NextSeq platform...
May 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29522538/exome-wide-somatic-mutation-characterization-of-small-bowel-adenocarcinoma
#9
Ulrika A Hänninen, Riku Katainen, Tomas Tanskanen, Roosa-Maria Plaketti, Riku Laine, Jiri Hamberg, Ari Ristimäki, Eero Pukkala, Minna Taipale, Jukka-Pekka Mecklin, Linda M Forsström, Esa Pitkänen, Kimmo Palin, Niko Välimäki, Netta Mäkinen, Lauri A Aaltonen
Small bowel adenocarcinoma (SBA) is an aggressive disease with limited treatment options. Despite previous studies, its molecular genetic background has remained somewhat elusive. To comprehensively characterize the mutational landscape of this tumor type, and to identify possible targets of treatment, we conducted the first large exome sequencing study on a population-based set of SBA samples from all three small bowel segments. Archival tissue from 106 primary tumors with appropriate clinical information were available for exome sequencing from a patient series consisting of a majority of confirmed SBA cases diagnosed in Finland between the years 2003-2011...
March 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29505011/anti-epidermal-growth-factor-receptor-therapy-in-small-bowel-adenocarcinoma-case-report-and-literature-review
#10
REVIEW
Rosa Falcone, Michela Roberto, Marco Filetti, Elisabetta Anselmi, Paolo Marchetti
RATIONALE: Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal cancer, thus limited data about treatment for advanced disease are available. The lack of specific guidelines has justified the use of therapeutic protocols usually applied in advanced colorectal cancer. Few and preliminary data have suggested possible clinical benefit from the use of target therapy such as bevacizumab and cetuximab. PATIENT CONCERNS: We present the case of a young woman who was admitted to the emergency department for acute abdominal pain, nausea, and vomiting related to a jejunal stenosis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29484565/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-metastases-from-a-small-bowel-adenocarcinoma-multi-institutional-experience
#11
Yang Liu, Yutaka Yonemura, Edward A Levine, Olivier Glehen, Diane Goere, Dominique Elias, David L Morris, Paul H Sugarbaker, Jean J Tuech, Peter Cashin, John D Spiliotis, Ignace de Hingh, Wim Ceelen, Joel M Baumgartner, Pompiliu Piso, Kanji Katayama, Marcello Deraco, Shigeki Kusamura, Marc Pocard, François Quenet, Sachio Fushita
BACKGROUND: The multi-institutional registry in this study evaluated the outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal metastases (PM) from small bowel adenocarcinoma (SBA). METHODS: A multi-institutional data registry including 152 patients with PM from SBA was established. The primary end point was overall survival (OS) after CRS plus HIPEC. RESULTS: Between 1989 and 2016, 152 patients from 21 institutions received a treatment of CRS plus HIPEC...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29482082/metastatic-gastric-adenocarcinoma-and-synchronous-carcinoid-tumour-mimicking-appendicitis-a-case-report
#12
Q B Tran, R Mizumoto, S Ratnayake, B Strekozov
INTRODUCTION: Silent metastatic gastric adenocarcinoma presenting as appendicitis is very rare. Rare pathologies may be encountered during common operations such as appendicectomy and an awareness of possible alternative pathological entities would be helpful in a surgeon's wealth of knowledge. PRESENTATION OF CASE: A 63-year-old man presented with a three-day history of acute abdominal pain suggestive of appendicitis. Intra-operatively, a macroscopically inflamed and perforated appendix was found...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29457051/signet-ring-cell-carcinoma-ileal-crohn-disease-or-both-a-case-of-diagnostic-challenge
#13
Joana R Carvalho, Joana Tavares, Inês Goulart, Paula Moura Dos Santos, Emília Vitorino, Cristina Ferreira, Fátima Serejo, José Velosa
Signet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. Signet ring cell carcinoma originated from the ileum is extremely rare and the prognosis is poor. We present a case of small bowel obstruction with features suggesting Crohn disease of the ileum. The symptoms were chronic diarrhea and abdominal pain with a family history of inflammatory bowel disease. The patient underwent surgery and histopathology revealed both aspects of signet ring cell carcinoma and Crohn disease of the ileum...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29456091/frequency-of-human-papillomavirus-infection-in-patients-with-gastrointestinal-cancer
#14
F Roesch-Dietlen, A D Cano-Contreras, Y J Sánchez-Maza, J M Espinosa-González, M Á Vázquez-Prieto, E J Valdés-de la O, F Díaz-Roesch, M Á Carrasco-Arroniz, A Cruz-Palacios, P Grube-Pagola, A Sumoza-Toledo, H Vivanco-Cid, G Mellado-Sánchez, A Meixueiro-Daza, C S Silva-Cañetas, M G Carrillo-Toledo, R Lagunes-Torres, M Amieva-Balmori, P C Gómez-Castaño, J U Reyes-Huerta, J M Remes-Troche
INTRODUCTION AND AIM: Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. MATERIALS AND METHODS: A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz...
February 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29438094/anti-egfr-therapy-in-small-bowel-adenocarcinoma
#15
Rachael A Safyan, Alfred I Neugut
No abstract text is available yet for this article.
March 2018: Oncologist
https://www.readbyqxmd.com/read/29402880/adenocarcinoma-in-a-blind-loop-of-the-ileum-53-years-after-an-ileotransversostomy-procedure
#16
Ryohei Takei, Ichiro Onishi, Ryosuke Zaimoku, Naoki Makita, Yasumichi Yagi, Masato Kayahara
BACKGROUND Primary small bowel cancer is a rare malignancy; the common histopathological types are carcinoid and adenocarcinoma. Inflammatory bowel diseases and familial adenomatous polyposis are known risk factors for small bowel cancer. Additionally, cases of surgery-induced small bowel adenocarcinoma are sometimes reported after ileostomy. CASE REPORT A 84-year-old woman, who had undergone ileotransversostomy for intestinal obstruction due to postoperative adhesion following appendectomy at the age of 31 years, was referred to our hospital for further examination after experiencing abdominal pain in the right lower quadrant for 2 weeks...
February 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29394790/-a-case-of-jejunal-ectopic-pancreatic-cancer-with-small-bowel-obstruction
#17
Norikazu Yogi, Takashi Kaiho, Shinji Yanagisawa, Masaaki Kataoka, Masaki Nishimura, Soichi Kobayashi, Akira Okaniwa, Ryuichiro Suda, Takuya Yoichi, Nobumitsu Shiina, Mitsuhiko Yoshida, Naoko Mise, Shunichi Tsuchiya
Were port a caseof an 82-year-old man who presented with vomiting. Computed tomography(CT)revealed a jejunum tumor and small bowel obstruction. Enteroscopy revealed a protruded lesion and biopsy indicated adenocarcinoma. PET-CT revealed nothing without jejunal tumor. Therefore, with a preoperative diagnosis of primary small bowel cancer, we performed operation. Surgery indicated peritoneal disseminations and a jejunal tumor 40 cm distal from the ligament of Treitz, and we performed small bowel partial resection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29381126/the-evolving-management-of-small-bowel-adenocarcinoma
#18
Eelco de Bree, Koen P Rovers, Dimitris Stamatiou, John Souglakos, Dimosthenis Michelakis, Ignace H de Hingh
BACKGROUND: Small bowel adenocarcinoma (SBA) is rare despite the fact that the small bowel represents the longest part and has the largest surface of all alimentary tract sections. Its incidence is 50-fold lower than that of colorectal carcinoma. It is often diagnosed at an advanced stage due to atypical and late symptoms, its low index of suspicion, difficult endoscopic access and poor detection by radiological imaging, resulting in impaired outcome. Due to its rarity and being molecularly a unique intestinal cancer, data regarding its optimal management are relatively sparse...
January 30, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29379738/management-of-advanced-adenocarcinoma-in-indiana-pouch-urinary-diversion
#19
Michael A Bell, Edward J Wright, Sandy H Fang, Michael H Johnson, Nikolai A Sopko
Adenocarcinoma is a rare finding following urinary diversion with gastrointestinal segments. This report describes an 80-year-old woman with a history of bladder cancer who subsequently developed a pT4 adenocarcinoma 8 years following her radical cystectomy and Indiana Pouch continent urinary diversion. An en bloc resection of the pouch and affected small bowel was performed and the patient underwent conversion to an ileal conduit diversion. We use this case to highlight a mechanism for possible pathogenesis and the management of adenocarcinoma in urinary diversions including the need for regular surveillance and the surgical approach...
March 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29364012/ileocecal-intussusception-extending-to-left-colon-due-to-endometriosis
#20
M Rodriguez-Lopez, M Bailon-Cuadrado, F J Tejero-Pintor, E Choolani, G Fernandez-Perez, A Tapia-Herrero
Bowel involvement in endometriosis is uncommon and is most frequently located in the sigmoid colon and the rectum. We present a case in a 37-year-old woman of a cecal endometrioid mass complicated with an ileocolic intussusception which extended beyond the splenic colon flexure. Careful manual extraction allowed a reduction of the intussusceptum, followed by an oncological right hemicolectomy. The patient suffered postoperative ileus, which was spontaneously solved. Intussusception is infrequent in the adult population and usually involves the small bowel...
March 2018: Annals of the Royal College of Surgeons of England
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