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https://www.readbyqxmd.com/read/29351714/-prevalence-and-phenomenology-of-psychotic-like-symptoms-in-borderline-personality-disorders-associations-with-suicide-attempts-and-use-of-psychiatric-inpatient-treatment
#1
Katrin Schroeder, Anja Schätzle, Pauline Kowohl, Lisa Leske, Christian G Huber, Ingo Schäfer
BACKGROUND: Psychotic-like symptoms are found in a subgroup of borderline patients (BPD). Reported prevalence is heterogeneous (up to 50% affected). Investigations in Germany have not been conducted so far. Furthermore, the precise phenomenology of the psychotic symptoms and the effects on suicidal behavior and the use of inpatient psychiatric treatment are unclear. OBJECTIVES: The aim of the study was to investigate prevalence rates and phenomenology of psychotic-like symptoms...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351689/microvascular-decompression-for-patients-with-hemifacial-spasm-associated-with-common-trunk-anomaly-of-the-cerebellar-arteries-case-study-and-review-of-literature
#2
Ehab El Refaee, Christian Rosenstengel, Joerg Baldauf, Dirk T Pillich, Marc Matthes, Henry W S Schroeder
BACKGROUND: Few previous studies have described the origin of both anterior and posterior inferior cerebellar arteries from one vessel as a common trunk anomaly. No previous studies have clearly described the aforementioned anomaly depending on intraoperative endoscopic visualization. OBJECTIVE: To evaluate the association of a common trunk anomaly with hemifacial spasm, which makes microvascular decompression more challenging. METHODS: All patients with common trunk anomaly associated with hemifacial spasm who received surgical treatment between 2006 and 2015 in our institution were identified in our prospectively collected database...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351673/the-barrow-neurological-institute-grading-scale-as-a-predictor-for-delayed-cerebral-ischemia-and-outcome-after-aneurysmal-subarachnoid-hemorrhage-data-from-a-nationwide-patient-registry-swiss-sos
#3
Marian Christoph Neidert, Nicolai Maldaner, Martin Nikolaus Stienen, Michel Roethlisberger, Daniel W Zumofen, Donato D'Alonzo, Serge Marbacher, Rodolfo Maduri, Isabel Charlotte Hostettler, Bawarjan Schatlo, Michel M Schneider, Martin A Seule, Daniel Schöni, Johannes Goldberg, Christian Fung, Marta Arrighi, Daniele Valsecchi, Philippe Bijlenga, Karl Schaller, Oliver Bozinov, Luca Regli, Jan-Karl Burkhardt
BACKGROUND: The Barrow Neurological Institute (BNI) scale is a novel quantitative scale measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This scale could replace the Fisher score, which was traditionally used for DCI prediction. OBJECTIVE: To validate the BNI scale. METHODS: All patient data were obtained from the prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, BNI scale, DCI, and modified Rankin Scale (mRS) score up to the 1-yr follow-up (1FU) were available for descriptive and univariate statistics...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29351610/orthotopic-branched-endovascular-aortic-arch-repair-in-patients-who-cannot-undergo-classical-surgery
#4
Martin Czerny, Bartosz Rylski, Julia Morlock, Holger Schröfel, Friedhelm Beyersdorf, Bertrand Saint Lebes, Olivier Meyrignac, Fatima Mokrane, Mario Lescan, Christian Schlensak, Constatijn Hazenberg, Trijntje Bloemert-Tuin, Sue Braithwaite, Joost van Herwaarden, Herve Rousseau
OBJECTIVES: Our goal was to assess the results after orthotopic branched endovascular aortic arch repair using a new double-branch endoprosthesis in patients with thoracic aortic disease affecting the aortic arch who cannot undergo classical surgery. METHODS: Within a 4-year period, 15 patients with thoracic aortic disease affecting the aortic arch were treated with the Bolton Relay plus double-branch endoprosthesis (Bolton Medical, Sunrise, FL, USA). We assessed clinical outcome, occurrence of endoleaks and the need for secondary interventions...
January 16, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29351495/implementing-prehospital-evidence-based-guidelines-a-systematic-literature-review
#5
Jennifer N Fishe, Remle P Crowe, Rebecca E Cash, Nikiah G Nudell, Christian Martin-Gill, Christopher T Richards
OBJECTIVE: As prehospital research advances, more evidence-based guidelines (EBGs) are implemented into emergency medical services (EMS) practice. However, incomplete or suboptimal prehospital EBG implementation may hinder improvement in patient outcomes. To inform future efforts, this study's objective was to review existing evidence pertaining to prehospital EBG implementation methods. METHODS: This study was a systematic literature review and evaluation following the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology...
January 19, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29350913/environmentally-triggerable-retinoic-acid-inducible-gene-i-agonists-using-synthetic-polymer-overhangs
#6
Christian R Palmer, Max E Jacobson, Olga Fedorova, Anna M Pyle, John T Wilson
Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor (PRR) that potently activates antiviral innate immunity upon recognition of 5' triphosphorylated double-stranded RNA (pppRNA). Accordingly, RNA ligands of the RIG-I pathway have recently emerged as promising antiviral agents, vaccine adjuvants, and cancer immunotherapeutics. However, RIG-I is expressed constitutively in virtually all cell types, and therefore administration of RIG-I agonists causes risk for systemic inflammation and possible dose-limiting toxicities...
January 19, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29350834/proton-pump-inhibitors-elevate-infection-rate-in-cardiothoracic-surgery-patients-by-influencing-pmn-function-in-vitro-and-in-vivo
#7
Carolin Maria Haas, Martina Maywald, Andreas Goetzenich, Christian Stoppe, Lothar Rink
Proton-pump inhibitors (PPI) as pantoprazole are highly effective acid suppressive agents that belong to the world's most sold medication. However, they are pronounced to have immunosuppressive aspects. In our study, a negative influence of PPI on functions of polymorphonuclear cells in vitro like phagocytosis, oxidative burst, chemotaxis, and killing activity was shown, whereas formation of neutrophil extracellular traps (NET)osis remained unaffected. Pantoprazole stimulation additionally reduced the production of the proinflammatory cytokine IL-1β in whole blood assay as well as the production of IL-2 and IFN-γ after whole blood stimulation with phytohaemagglutinin...
January 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29350807/mait-cells-and-viruses
#8
James E Ussher, Christian B Willberg, Paul Klenerman
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are distinctive in another respect, since they respond quite sensitively to non-TCR signals, especially in the form of inflammatory cytokines...
January 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29350434/the-cystine-glutamate-exchanger-xct-slc7a11-is-expressed-in-significant-concentrations-in-a-subpopulation-of-astrocytes-in-the-mouse-brain
#9
Sigrid Ottestad-Hansen, Qiu Xiang Hu, Virgine Veronique Follin-Arbelet, Eduard Bentea, Hideyo Sato, Ann Massie, Yun Zhou, Niels Christian Danbolt
The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertainty, however, remains as neither the expression levels nor the distribution of xCT have been unambiguously determined. In fact, xCT has been reported in astrocytes, neurons, oligodendrocytes and microglia, but most of the information derives from cell cultures. Here, we show by immunohistochemistry and by Western blotting that xCT is widely expressed in the central nervous system of both sexes...
January 19, 2018: Glia
https://www.readbyqxmd.com/read/29350292/disc-herniation-occult-on-preoperative-imaging-but-visualized-microsurgically-as-the-cause-of-idiopathic-thoracic-spinal-cord-herniation
#10
Christian T Ulrich, Christian Fung, Eike Piechowiak, Jan Gralla, Andreas Raabe, Jürgen Beck
Idiopathic spinal cord herniation (ISCH) through an anterior dural defect is rare and the cause is uncertain. Recently, through interpreting imaging studies, disc herniation was proposed to be a major cause for ISCH. We describe the case of a 50-year-old woman with progressive myelopathy who was diagnosed with a thoracic spinal cord herniation. Microsurgical exploration revealed an anterior vertical dural defect and a small concomitant disc herniation, occult on the preoperative imaging, which caused the dural defect and led to ISCH...
January 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29349612/dexamethasone-induced-leukocytosis-is-associated-with-poor-survival-in-newly-diagnosed-glioblastoma
#11
Daniel Dubinski, Sae-Yeon Won, Florian Gessler, Johanna Quick-Weller, Bedjan Behmanesh, Simon Bernatz, Marie-Therese Forster, Kea Franz, Karl-Heinz Plate, Volker Seifert, Patrick N Harter, Christian Senft
Despite its well-characterized side effects, dexamethasone is widely used in the pre-, peri- and postoperative neurosurgical setting due to its effective relief of tumor-induced symptoms through the reduction of tumor-associated edema. However, some patients show laboratory-defined dexamethasone induced elevation of white blood cell count, and its impact on glioblastoma progression is unknown. We retrospectively analyzed 113 patients with newly diagnosed glioblastoma to describe the incidence, risk factors and clinical features of dexamethasone-induced leukocytosis in primary glioblastoma patients...
January 18, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29349545/risk-of-discontinuation-of-clopidogrel-after-1-month-following-bare-metal-stents-a-propensity-score-adjusted-comparison-with-continued-administration-of-clopidogrel-after-drug-eluting-stents
#12
Christian M Valina, Sebastian Merz, Nikolaus Löffelhardt, Michael Amann, Miroslaw Ferenc, Christian Stratz, Franz-Josef Neumann, Willibald Hochholzer
In patients at high risk for bleeding undergoing percutaneous coronary intervention (PCI) the use of bare-metal-stent (BMS) is considered an option that allows discontinuation of clopidogrel after 4 weeks. We sought to investigate the risk of early discontinuation of clopidogrel in patients with BMS as compared with a 6-month course of clopidogrel after DES in patients with or without high on-treatment platelet reactivity (HTPR). In 765 consecutive patients undergoing PCI after loading with clopidogrel 600 mg, HTPR was tested by optical aggregometry and defined as residual platelet reactivity > 14%...
January 18, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29349478/affinity-to-host-population-stimulates-physical-growth-in-adult-offspring-of-turkish-migrants-in-germany
#13
Aydan Özer, Christiane Scheffler
Because of political conflicts and climate change, migration will be increased worldwide and integration in host societies is a challenge also for migrants. We hypothesize that migrants, who take up the challenge in a new social environment are taller than migrants who do not pose this challenge. We analyze by a questionnaire possible social, nutritional and ethnic influencing factors to body height (BH) of adult offspring of Turkish migrants (n = 82, 39 males) aged from 18 to 34 years (mean age 24.6 years)...
January 18, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29349293/experimenter-gender-and-replicability-in-science
#14
REVIEW
Colin D Chapman, Christian Benedict, Helgi B Schiöth
There is a replication crisis spreading through the annals of scientific inquiry. Although some work has been carried out to uncover the roots of this issue, much remains unanswered. With this in mind, this paper investigates how the gender of the experimenter may affect experimental findings. Clinical trials are regularly carried out without any report of the experimenter's gender and with dubious knowledge of its influence. Consequently, significant biases caused by the experimenter's gender may lead researchers to conclude that therapeutics or other interventions are either overtreating or undertreating a variety of conditions...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29349237/social-capital-and-pet-ownership-a-tale-of-four-cities
#15
Lisa Wood, Karen Martin, Hayley Christian, Steve Houghton, Ichiro Kawachi, Shannen Vallesi, Sandra McCune
•Pet ownership is significantly associated with higher levels of social capital.•Social capital was associated with pet ownership in the U.S. and Australia.•Results are not confined to dog owners nor dog walkers.•Pets are an under-recognized conduit for building social capital.
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29348861/primary-tumor-associated-expression-of-cxcr4-predicts-formation-of-local-and-systemic-recurrency-in-head-and-neck-squamous-cell-carcinoma
#16
Andreas Knopf, Leila Bahadori, Kristin Fritsche, Guido Piontek, Cord-Christian Becker, Percy Knolle, Achim Krüger, Henning Bier, Yin Li
Objectives: Despite modern treatment regimens, overall survival in head and neck squamous cell carcinomas (HNSCC) is less than 50% due to local and systemic disease recurrency. The current study aims to identify molecular markers in primary tumor specimens that predict the risk for local and systemic recurrency at the time of initial diagnosis. Methods: The study included clinic-pathological data of 1,057 HNSCC. MMP2/9, TIMP1/2, CXCR4, and CXCL12 immunohistochemistry was done in 150 randomly selected specimens...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348673/quantification-of-massively-parallel-sequencing-libraries-a-comparative-study-of-eight-methods
#17
Christian Hussing, Marie-Louise Kampmann, Helle Smidt Mogensen, Claus Børsting, Niels Morling
Quantification of massively parallel sequencing libraries is important for acquisition of monoclonal beads or clusters prior to clonal amplification and to avoid large variations in library coverage when multiple samples are included in one sequencing analysis. No gold standard for quantification of libraries exists. We assessed eight methods of quantification of libraries by quantifying 54 amplicon, six capture, and six shotgun fragment libraries. Chemically synthesized double-stranded DNA was also quantified...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348496/natriuretic-peptides-promote-glucose-uptake-in-a-cgmp-dependent-manner-in-human-adipocytes
#18
Marine Coué, Valentin Barquissau, Pauline Morigny, Katie Louche, Corinne Lefort, Aline Mairal, Christian Carpéné, Nathalie Viguerie, Peter Arner, Dominique Langin, Mikael Rydén, Cedric Moro
Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it is unknown whether NP signalling in human AT relates to insulin sensitivity and modulates glucose metabolism. We here show in two European cohorts that the NP receptor guanylyl cyclase-A (GC-A) expression in subcutaneous AT was down-regulated as a function of obesity grade while adipose NP clearance receptor (NPRC) was up-regulated...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348430/rotator-side-chains-trigger-cooperative-transition-for-shape-and-function-memory-effect-in-organic-semiconductors
#19
Hyunjoong Chung, Dmytro Dudenko, Fengjiao Zhang, Gabriele D'Avino, Christian Ruzié, Audrey Richard, Guillaume Schweicher, Jérôme Cornil, David Beljonne, Yves Geerts, Ying Diao
Martensitic transition is a solid-state phase transition involving cooperative movement of atoms, mostly studied in metallurgy. The main characteristics are low transition barrier, ultrafast kinetics, and structural reversibility. They are rarely observed in molecular crystals, and hence the origin and mechanism are largely unexplored. Here we report the discovery of martensitic transition in single crystals of two different organic semiconductors. In situ microscopy, single-crystal X-ray diffraction, Raman and nuclear magnetic resonance spectroscopy, and molecular simulations combined indicate that the rotating bulky side chains trigger cooperative transition...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348389/efficacy-of-curcumin-as-adjuvant-therapy-to-induce-or-maintain-remission-in-ulcerative-colitis-patients-an-evidence-based-clinical-review
#20
Marcellus Simadibrata, Christopher Christian Halimkesuma, Benedicta Mutiara Suwita
BACKGROUND: treatment guidelines for ulcerative colitis (UC) not yet established. Currently, mesalazine, corticosteroids, and immunomodulators are treatment options for UC. However, they are known to have unpleaseant side effects such as nausea, vomiting, headaches, hepatitis, and male infertility. Curcumin is found in Turmeric plants (Curcuma longa L.), which possesses both anti-inflammatory and antioxidant properties. This study aimed to determine whether curcumin as adjuvant therapy can induce or maintain remission in UC patients...
October 2017: Acta Medica Indonesiana
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