keyword
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#1
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537095/-not-available
#2
JOURNAL ARTICLE
Eloy Salinas, María Cecilia De Pauw, María Fernanda Aguirre, María Jimena Marro, Christian Ballejo, Alejandro Félix Sturniolo, Alicia E B Lawrynowicz
El objetivo de este estudio fue estimar la prevalencia de diabetes mellitus (DM) y factores de riesgo cardiovascular en una población rural de la provincia de San Luis, Argentina. Estudio transversal desarrollado entre septiembre y noviembre de 2017 con habitantes de 18 años y más de cuatro localidades del departamento Juan Martín de Pueyrredón, San Luis. Los participantes respondieron preguntas por autorreporte sobre aspectos sociodemográficos, hábitos, factores psicosociales y de riesgo para enfermedades no transmisibles; se realizaron mediciones físicas, cuestionario FINDIRSC y extracción de muestras de sangre...
March 27, 2024: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/38536993/factors-associated-with-voice-related-quality-of-life-among-patients-with-temporomandibular-disorders
#3
JOURNAL ARTICLE
Rüdiger Emshoff, Magdalena Astl, Aris Ioannis Giotakis, Linus Christian Hupp, Andreas Kolk
BACKGROUND: Research would be important for obtaining a better understanding of voice complaints among patients with temporomandibular disorders (TMD). OBJECTIVE: The identification of predictors of voice disorders associated with TMD pain was made according to Diagnostic Criteria for TMD (DC/TMD) Axis I. METHODOLOGY: Functional limitations were measured using the Jaw Functional Limitation Scales for mastication (JFLS-M), jaw mobility (JFLS-JM), and verbal and emotional expression (JFLS-VEE)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536960/unveiling-the-molecular-characteristics-origins-and-formation-mechanism-of-reduced-nitrogen-organic-compounds-in-the-urban-atmosphere-of-shanghai-using-a-versatile-aerosol-concentration-enrichment-system
#4
JOURNAL ARTICLE
Munila Abudumutailifu, Xiaona Shang, Lina Wang, Miaomiao Zhang, Huihui Kang, Yunqian Chen, Ling Li, Ruiting Ju, Bo Li, Huiling Ouyang, Xu Tang, Chunlin Li, Lin Wang, Xinke Wang, Christian George, Yinon Rudich, Renhe Zhang, Jianmin Chen
Reduced nitrogen-containing organic compounds (NOCs) in aerosols play a crucial role in altering their light-absorption properties, thereby impacting regional haze and climate. Due to the low concentration levels of individual NOCs in the air, the utilization of accurate detection and quantification technologies becomes essential. For the first time, this study investigated the diurnal variation, chemical characteristics, and potential formation pathways of NOCs in urban ambient aerosols in Shanghai using a versatile aerosol concentration enrichment system (VACES) coupled with HPLC-Q-TOF-MS...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38536921/glutamine-antagonist-drp-104-suppresses-tumor-growth-and-enhances-response-to-checkpoint-blockade-in-keap1-mutant-lung-cancer
#5
JOURNAL ARTICLE
Ray Pillai, Sarah E LeBoeuf, Yuan Hao, Connie New, Jenna L E Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I Sayin, Kamal M Khanna, Kwok-Kin Wong, Robert Wild, Aristotelis Tsirigos, John T Poirier, Charles M Rudin, Shawn M Davidson, Sergei B Koralov, Thales Papagiannakopoulos
Loss-of-function mutations in KEAP1 frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting the need for the development of targeted therapies. We previously showed that KEAP1 mutant tumors consume glutamine to support the metabolic rewiring associated with NRF2-dependent antioxidant production. Here, using preclinical patient-derived xenograft models and antigenic orthotopic lung cancer models, we show that the glutamine antagonist prodrug DRP-104 impairs the growth of KEAP1 mutant tumors...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536915/multiple-parallel-cell-lineages-in-the-developing-mammalian-cerebral-cortex
#6
JOURNAL ARTICLE
Lucia Del-Valle-Anton, Salma Amin, Daniela Cimino, Florian Neuhaus, Elena Dvoretskova, Virginia Fernández, Yigit K Babal, Cristina Garcia-Frigola, Anna Prieto-Colomina, Raquel Murcia-Ramón, Yuki Nomura, Adrián Cárdenas, Chao Feng, Juan Antonio Moreno-Bravo, Magdalena Götz, Christian Mayer, Víctor Borrell
Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate basal progenitors, and these produce neurons. How this occurs in species with expanded germinal zones and a folded cortex, such as human, remains unclear. We used single-cell RNA sequencing from individual cortical germinal zones in ferret and barcoded lineage tracking to determine the molecular diversity of progenitor cells and their lineages. We identified multiple RGC classes that initiate parallel lineages, converging onto a common class of newborn neuron...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#7
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536769/reversible-c%C3%A2-n-bond-formation-controls-charge-separation-in-an-aza-diarylethene-photoswitch
#8
JOURNAL ARTICLE
Maximilian Sacherer, Sofia Gracheva, Harald Maid, Christian Placht, Frank Hampel, Henry Dube
Diarylethenes belong to the most eminent photoswitches and have been studied for many decades. They are found in virtually every field of application and have become highly valuable molecular tools for instilling light-responsiveness into materials, catalysts, biological systems, or pharmacology. In this work, we present a novel and distinct type of pyrimidine-based aza-diarylethene, which undergoes a highly unusual zwitterion-forming photoreaction. During this fully reversible process, a CN double bond is established under concomitant aromatization and thiophene-ring opening...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#9
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536550/oromandibular-dystonia-from-onset-to-spread-a-multicenter-italian-study
#10
JOURNAL ARTICLE
Assunta Trinchillo, Marcello Esposito, Carmen Terranova, Vincenzo Rizzo, Giovanni Fabbrini, Gina Ferrazzano, Daniele Belvisi, Roberto Erro, Paolo Barone, Francesco Bono, Francesca Di Biasio, Anna Rita Bentivoglio, Christian Lettieri, Maria Concetta Altavista, Cesa Lorella Maria Scaglione, Alberto Albanese, Marcello Mario Mascia, Antonella Muroni, Antonio Pisani, Alfredo Berardelli, Giovanni Defazio
BACKGROUND: Detailed information about the epidemiological and phenomenological differences among the aetiological subtypes of oromandibular dystonia (OMD) is lacking. Moreover, the OMD tendency to spread to other body sites has never been investigated. AIM: To compare the main demographic and clinical features of OMD in different aetiological groups and assess the risk of spread. MATERIALS AND METHODS: We retrospectively analysed data from patients contained in the Italian Dystonia Registry...
March 27, 2024: Neurological Sciences
https://read.qxmd.com/read/38536546/prognostic-genomic-alterations-in-patients-undergoing-liver-resection-for-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
S B Nordkild, L B Ahlborn, C W Yde, J M Kugler, J Klubien, D Akdag, G L Willemoe, S D Nielsen, Hans-Christian Pommergaard
INTRODUCTION: Genetic mutations and amplifications found in hepatocellular carcinoma (HCC) have a potentially prognostic impact. The aim of this study was to investigate the prognostic value of mutations and amplifications in HCC from patients that were liver resected. METHODS: Patients liver resected for HCC at Copenhagen University Hospital Rigshospitalet between May 2014 and January 2018 were included. DNA from freshly frozen tumour tissue was investigated with TruSight Oncology 500...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#12
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38536107/benchmarking-machine-learning-based-real-time-respiratory-signal-predictors-in-4d-sbrt
#13
JOURNAL ARTICLE
Lukas Wimmert, Maximilian Nielsen, Frederic Madesta, Tobias Gauer, Christian Hofmann, Rene Werner
BACKGROUND: Stereotactic body radiotherapy of thoracic and abdominal tumors has to account for respiratory intrafractional tumor motion. Commonly, an external breathing signal is continuously acquired that serves as a surrogate of the tumor motion and forms the basis of strategies like breathing-guided imaging and gated dose delivery. However, due to inherent system latencies, there exists a temporal lag between the acquired respiratory signal and the system response. Respiratory signal prediction models aim to compensate for the time delays and to improve imaging and dose delivery...
March 27, 2024: Medical Physics
https://read.qxmd.com/read/38536036/the-gtpase-activating-protein-gyp7-regulates-rab7-ypt7-activity-on-late-endosomes
#14
JOURNAL ARTICLE
Nadia Füllbrunn, Raffaele Nicastro, Muriel Mari, Janice Griffith, Eric Herrmann, René Rasche, Ann-Christin Borchers, Kathrin Auffarth, Daniel Kümmel, Fulvio Reggiori, Claudio De Virgilio, Lars Langemeyer, Christian Ungermann
Organelles of the endomembrane system contain Rab GTPases as identity markers. Their localization is determined by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). It remains largely unclear how these regulators are specifically targeted to organelles and how their activity is regulated. Here, we focus on the GAP Gyp7, which acts on the Rab7-like Ypt7 protein in yeast, and surprisingly observe the protein exclusively in puncta proximal to the vacuole. Mistargeting of Gyp7 to the vacuole strongly affects vacuole morphology, suggesting that endosomal localization is needed for function...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38535880/operational-differences-between-product-development-partnership-pharmaceutical-industry-and-investigator-initiated-clinical-trials
#15
JOURNAL ARTICLE
Eric I Nebie, Peter van Eeuwijk, Hélène N Sawadogo, Elisabeth Reus, Jürg Utzinger, Christian Burri
Medicine development is a lengthy endeavour. Increasing regulatory stringency and trial complexity might lead to reduced efficiency, dwindled output, and elevated costs. However, alternative models are possible. We compared the operational differences between pharmaceutical industry sponsored trials, product development partnership trials, and investigator-initiated trials to identify key drivers of inefficiency in clinical research. We conducted an exploratory mixed-methods study with stakeholders, including clinical trial sponsors, contract research organisations, and investigators...
February 29, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535813/report-from-the-29th-meeting-on-toxinology-toxins-from-the-wild-to-the-lab-organized-by-the-french-society-of-toxinology-on-30-november-1-december-2023
#16
Pascale Marchot, Ziad Fajloun, Christian Legros, Évelyne Benoit, Sylvie Diochot
The French Society of Toxinology (SFET), which celebrated its 30th anniversary this year, organized its 29th annual Meeting (RT29), shared by 87 participants, on 30 November-1 December 2023. The RT29 main theme, "Toxins: From the Wild to the Lab", focused on research in the field of animal venoms and animal, bacterial, fungal, or plant toxins, from their discovery in nature to their study in the laboratory. The exploration of the functions of toxins, their structures, their molecular or cellular ligands, their mode of action, and their potential therapeutic applications were emphasized during oral communications and posters through three sessions, of which each was dedicated to a secondary theme...
March 13, 2024: Toxins
https://read.qxmd.com/read/38535752/extending-the-lifetime-of-vanadium-redox-flow-batteries-by-reactivation-of-carbon-electrode-materials
#17
JOURNAL ARTICLE
Muhammad Adeel Ashraf, Stylianos Daskalakis, Matthias Kogler, Markus Ostermann, Soniya Gahlawat, Seohee Son, Pavel Mardilovich, Markus Valtiner, Christian M Pichler
The degradation and aging of carbon felt electrodes is a main reason for the performance loss of Vanadium Redox Flow Batteries over extended operation time. In this study, the chemical mechanisms for carbon electrode degradation are investigated and distinct differences in the degradation mechanisms on positive and negative electrodes have been revealed. A combination of surface analysis techniques such as X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and Electrochemical Impedance Spectroscopy (EIS) was applied for this purpose...
March 27, 2024: Nanoscale
https://read.qxmd.com/read/38535708/positive-aspects-and-potential-drawbacks-of-implementing-digital-teaching-learning-scenarios-in-health-professions-using-nursing-education-as-an-example-a-research-report-from-germany
#18
JOURNAL ARTICLE
Lydia Pfeifer, Sophia Fries, Alexander Stirner, Lisa Nagel, Christian Cohnen, Leona Aschentrup, Marleen Schönbeck, Annette Nauerth, Patrizia Raschper, Tim Herzig, Kamil J Wrona
BACKGROUND: Learning arrangements in health care profession education are increasingly taking place in digital environments. Virtual reality (VR) in nursing education, as a digital element, is the subject of controversial debate. On one hand, it supports the authenticity of case studies by adding realistic perspectives and information. On the other hand, the costs of developing and maintaining software and hardware hinder its long-term implementation. Based in the German context, our aim is to promote the adoption of innovative digital methods in nursing education and to offer invaluable experiences from the field...
February 22, 2024: Nursing Reports
https://read.qxmd.com/read/38535666/optical-analysis-of-perovskite-iii-v-nanowires-interpenetrated-tandem-solar-cells
#19
JOURNAL ARTICLE
Matteo Tirrito, Phillip Manley, Christiane Becker, Eva Unger, Magnus T Borgström
Multi-junction photovoltaics approaches are being explored to mitigate thermalization losses that occur in the absorption of high-energy photons. However, the design of tandem cells faces challenges such as light reflection and parasitic absorption. Nanostructures have emerged as promising solutions due to their anti-reflection properties, which enhances light absorption. III-V nanowires (NWs) solar cells can achieve strong power conversion efficiencies, offering the advantage of potentially integrating tunnel diodes within the same fabrication process...
March 14, 2024: Nanomaterials
https://read.qxmd.com/read/38535619/inhibition-of-mir-33a-5p-in-macrophage-like-cells-in-vitro-promotes-apoai-mediated-cholesterol-efflux
#20
JOURNAL ARTICLE
Olanrewaju Oladosu, Emma Chin, Christian Barksdale, Rhonda R Powell, Terri Bruce, Alexis Stamatikos
Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where atherosclerotic plaque accumulates and where lipid-laden foam cells reside. Intimal foam cells comprise of both monocyte-derived macrophages and macrophage-like cells (MLC) of vascular smooth muscle cell (VSMC) origin. Foam cells can remove cholesterol via apoAI-mediated cholesterol efflux and this process is regulated by the transporter ABCA1. The microRNA miR-33a-5p is thought to be atherogenic via silencing ABCA1 which promotes cholesterol retention and data has shown inhibiting miR-33a-5p in macrophages may be atheroprotective via enhancing apoAI-mediated cholesterol efflux...
February 28, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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