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Kimitoshi Kubo, Xinhan Zhang, Ikko Tanaka, Noriko Kimura
While the differential diagnosis of duodenal adenocarcinoma versus adenoma remains the key to determining treatment strategies in patients with suspected duodenal adenocarcinoma, the role of linked color imaging (LCI) in their differential diagnosis remains insufficiently documented. In this case, esophagogastroduodenoscopy (EGD) was performed on a 67-year-old man for anemia, which revealed a 20-mm-sized, whitish, partially reddish, pedunculated lesion located in the duodenal bulb on white light imaging. Using LCI, the lesion was highlighted as a whitish, pedunculated lesion with its central and inferior areas depicted as orangish and reddish, respectively...
February 2024: Curēus
#22
JOURNAL ARTICLE
Zhengchun Zhu, Hong Liu, Fei Zhong
BACKGROUND AND OBJECTIVES: Duodenal adenocarcinoma (DAC) is a rare tumor that is often accompanied by liver metastasis in advanced stages. The aim of this study was to evaluate the correlation between clinicopathological characteristics and survival in DAC patients with liver metastasis, and to explore appropriate treatment options. METHODS: 482 DAC patients with liver metastasis were retrospectively identified from the Surveillance, Epidemiology and End Results (SEER) database (2011-2020)...
2024: Clinical and Experimental Gastroenterology
#23
JOURNAL ARTICLE
Takashi Taniguchi, Noboru Ideno, Tomoyuki Araki, Shun Miura, Masahiro Yamamoto, Tomoki Nakafusa, Nobuhiro Higashijima, Takeo Yamamoto, Koji Tamura, So Nakamura, Toshiya Abe, Naoki Ikenaga, Kohei Nakata, Kenoki Ohuchida, Yoshinao Oda, Takao Ohtsuka, Masafumi Nakamura
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate owing to its late diagnosis and aggression. In addition, there are relatively few minimally invasive screening methods for the early detection of PDAC, making the identification of biomarkers for this disease a critical priority. Recent studies have reported that microRNAs in extracellular vesicles (EV-miRs) from bodily fluids can be useful for the diagnosis of PDACs. Given this, we designed this study to evaluate the utility of cancer EVs extracted from duodenal fluid (DF) and their resident EV-miRs as potential biomarkers for the detection of PDAC...
April 2024:
#24
JOURNAL ARTICLE
Giuseppe Vanella, Giuseppe Dell'Anna, Agostino Cosenza, Federica Pedica, Maria Chiara Petrone, Alberto Mariani, Livia Archibugi, Gemma Rossi, Matteo Tacelli, Piera Zaccari, Roberto Leone, Domenico Tamburrino, Giulio Belfiori, Massimo Falconi, Luca Aldrighetti, Michele Reni, Andrea Casadei Gardini, Claudio Doglioni, Gabriele Capurso, Paolo Giorgio Arcidiacono
Background and study aims Besides increasing adequacy, rapid on-site evaluation (ROSE) during endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP) may impact choices and timing of subsequent therapeutic procedures, yet has been unexplored. Patients and methods This was a retrospective evaluation of a prospectively maintained database of a tertiary, academic centre with availability of ROSE and hybrid EUS-ERCP suites. All consecutive patients referred for pathological confirmation of suspected malignancy and jaundice or gastric outlet obstruction (GOO) between Jan-2020 and Sep-2022 were included...
February 2024: Endoscopy International Open
#25
JOURNAL ARTICLE
Ken Yamashita, Shiro Oka, Takeshi Yamada, Keigo Mitsui, Hironori Yamamoto, Keiichi Takahashi, Akio Shiomi, Kinichi Hotta, Yoji Takeuchi, Toshio Kuwai, Fumio Ishida, Shin-Ei Kudo, Shoichi Saito, Masashi Ueno, Eiji Sunami, Tomoki Yamano, Michio Itabashi, Kazuo Ohtsuka, Yusuke Kinugasa, Takayuki Matsumoto, Tamotsu Sugai, Toshio Uraoka, Koichi Kurahara, Shigeki Yamaguchi, Tomohiro Kato, Masazumi Okajima, Hiroshi Kashida, Yoshito Akagi, Hiroaki Ikematsu, Masaaki Ito, Motohiro Esaki, Masaya Kawai, Takashi Yao, Madoka Hamada, Takahiro Horimatsu, Keiji Koda, Yasumori Fukai, Koji Komori, Yusuke Saitoh, Yukihide Kanemitsu, Hiroyuki Takamaru, Kazutaka Yamada, Hiroaki Nozawa, Tetsuji Takayama, Kazutomo Togashi, Eiji Shinto, Takehiro Torisu, Akira Toyoshima, Naoki Ohmiya, Takeshi Kato, Eigo Otsuji, Shinji Nagata, Yojiro Hashiguchi, Kenichi Sugihara, Yoichi Ajioka, Shinji Tanaka
BACKGROUND: The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. METHODS: We analyzed 354 patients with 358 PSBAs, between January 2008 and December 2017, at 44 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum. RESULTS: The median age was 67 years (218 males, 61.6%). The average tumor size was 49...
February 27, 2024: Journal of Gastroenterology
#26
JOURNAL ARTICLE
Hon-Fan Lai, Shin-E Wang, Shih-Chin Chen, Bor-Shiuan Shyr, Yi-Ming Shyr, Bor-Uei Shyr
BACKGROUND: Duodenal adenocarcinoma is rare and its prognostic factors remain controversial. In our study, the role of cell-free deoxyribonucleic acid (cfDNA) as prognostic factor in duodenal adenocarcinoma was evaluated. METHODS: From June 2003 to July 2021, plasma samples were collected from forty-one patients with duodenal adenocarcinoma. Plasma cfDNA was assessed in combination with clinicopathological and biochemical characteristics. Univariate and multivariate analyses were conducted to identify independent prognostic factors for overall survival with a Cox proportional hazards regression model...
February 23, 2024: Journal of the Chinese Medical Association: JCMA
#27
REVIEW
Zeynab Marzhoseyni, Mohammad Javad Mousavi, Somayeh Ghotloo
Helicobacter pylori (H. pylori) is one of the most prevalent human pathogens and the leading cause of chronic infection in almost half of the population in the world (~59%). The bacterium is a major leading cause of chronic gastritis, gastric and duodenal ulcers, and two type of malignancies, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Despite the immune responses mounted by the host, the bacteria are not cleared from the body resulting in a chronic infection accompanied by a chronic inflammation...
2024: Helicobacter
#28
JOURNAL ARTICLE
Bena Law, John Windsor, Saxon Connor, Jonathan Koea, Sanket Srinivasa
BACKGROUND: The majority of patients with pancreatic adenocarcinoma (PDAC) have advanced disease at presentation, preventing treatment with curative intent. Management of these patients is often provided by surgical teams for whom there are a lack of widely accepted strategies for care. The aim of this study was to conduct a systematic review to identify key issues in patients with advanced PDAC and integrate the evidence to form a care bundle checklist for use in surgical clinics. METHODS: A systematic review of the literature was performed regarding best supportive care for advanced PDAC according to the PRISMA guidelines...
February 17, 2024: ANZ Journal of Surgery
#29
EDITORIAL
Masao Yoshida
No abstract text is available yet for this article.
February 14, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
#30
JOURNAL ARTICLE
Yoshiki Taniguchi, Junji Kawada, Junya Fujita, Shigeyuki Tamura, Yoshitaka Okauchi, Minami Maruyama, Tomonori Nomura, Manatsu Mizuno, Kei Asukai, Hideki Osawa, Tomoya Kishimoto, Ho Min Kim, Shinichi Yoshioka, Sosuke Kido, Yo Sasaki
Here we report the case of a patient with advanced gastric cancer who presented with duodenal intramural metastasis based on the pathological results after surgery. The patient was 78-year-old female, who was referred to our department for further evaluation and treatment of upper abdominal pain. An upper gastrointestinal series demonstrated a tumor occupying the lesser curvature of the gastric body. Biopsy specimens from the tumor demonstrated moderately to poorly differentiated adenocarcinoma. A computed tomography scan showed thickening of the gastric wall and swelling of the regional lymph nodes...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#31
JOURNAL ARTICLE
Toru Ishiguro, Aoi Sugino, Hiroyasu Ishikawa, Yu Muta, Tetsuya Ito, Azusa Yamamoto, Noriyasu Chika, Satoshi Hatano, Kumichika Uchida, Toshiro Ogura, Takatoshi Matsuyama, Yoichi Kumagai, Shigehisa Inokuma, Erito Mochiki, Hideyuki Ishida
Cronkhite-Canada syndrome(CCS)is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities. We report a rare case of CCS associated with gastric cancer and gastric outlet obstruction with a review of the literature. A 75-year-old man was admitted because of frequent vomiting and hypoproteinemia. He was diagnosed with CCS due to typical clinical and laboratory findings including alopecia, nail atrophy, hypoproteinemia, and typical gastrointestinal polyposis. Upper endoscopic examination also pointed out a large gastric cancer mainly located in the antrum and the reversible pyloric obstruction caused by the gastric tumor...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#32
JOURNAL ARTICLE
Tadashi Tsukamoto, Eijiro Edagawa, Shingo Togano, Takaaki Hori, Gen Tsujio, Tomohiro Kunimoto, Ryoji Kaizaki, Toru Inoue, Satoshi Takatsuka, Hiroko Fukushima
A 69-year-old woman was admitted to a territory hospital because of severe right hypochondoralgia after 2 weeks of internal medicine for persistent epigastralgia. Gastroduodenal endoscopy revealed a large tumor with a fistula in the duodenal bulb that expanded to the stomach. Histopathologically, the biopsy specimen indicated a poorly differentiated adenocarcinoma and HER2 negative. Computed tomography revealed that the tumor invaded the left lobe of the liver. The patient was referred to our hospital for cancer treatment...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#33
JOURNAL ARTICLE
Alessandro Mannucci, Marta Puzzono, Ajay Goel, Gabriela Möslein, Spyros Balafas, Mariaclelia Stefania Di Serio, Giulia Martina Cavestro
OBJECTIVES: Individuals with familial adenomatous polyposis (FAP) have an almost 20% lifetime risk of duodenal adenocarcinoma, currently the leading cause of death in FAP. The Spigelman staging system provides guidance on the surveillance intervals and the timing of prophylactic surgery. Still, its accuracy in predicting duodenal and papillary cancer development has not been systematically evaluated. We investigated the sensitivity and cancer risk of the Spigelman stages. METHODS: We performed a systematic review on PubMed, MEDLINE, EMBASE, and Cochrane and used a random-effects model to pool effect sizes...
January 31, 2024: American Journal of Gastroenterology
#34
Carmen Tisch, Daniel Ernst, Monika Falke, Philip Speicher, Mairi Ziaka
Nonbacterial thrombotic endocarditis is a rare, non-infectious complication associated with hypercoagulable states, such as malignancies and autoimmune diseases. Due to the difficulty distinguishing marantic endocarditis from infective endocarditis, the diagnosis is often delayed or even a postmortem finding. We present the case of a 70-year-old Caucasian female with marantic endocarditis secondary to metastatic duodenal adenocarcinoma. The patient presented with a short history of memory deficits, personality disturbances, and left homonymous hemianopia...
2024: SAGE Open Medical Case Reports
#35
JOURNAL ARTICLE
Lin-Qi Wen, Da-Wei Wei
BACKGROUND: One of the risk factors for esophageal adenocarcinoma is achalasia, an esophageal motility disorder that is typically treated surgically through laparotomy or laparoscopic surgery. The risk factors of gastric cardia cancer are also similar to esophageal adenocarcinoma due to the anatomical location of the gastric cardia close to the esophagus. There is currently no clinical evidence that achalching has a correlation with gastric cardia cancer. CASE SUMMARY: We report the case of an 85-year-old female patient was admitted to our department with dysphagia for 6 months...
January 26, 2024: Medicine (Baltimore)
#36
Koji Takahashi, Hiroshi Ohyama, Yuichi Takiguchi, Motoyasu Kan, Mayu Ouchi, Hiroki Nagashima, Kohichiroh Okitsu, Izumi Ohno, Naoya Kato
A 70-year-old woman presented to our hospital with abdominal discomfort. Gastrointestinal endoscopy revealed an ampullary tumor, while a biopsy revealed a pathological diagnosis of adenocarcinoma. No distant metastases were observed and neoadjuvant chemotherapy and surgical resection were planned. Shortly thereafter, she developed obstructive jaundice due to the ampullary carcinoma. The patient underwent endoscopic retrograde cholangiopancreatography, during which a straight plastic stent was placed in the bile duct...
April 2024: DEN Open
#37
JOURNAL ARTICLE
Natalia Zuberoa Rosado Dawid, Raquel Díaz Martínez, Asunción Ramos Meca
We present the case of an 82-year-old woman with a history of well-differentiated adenocarcinoma of the cecum, stage pT3N1M0, treated ten years before with right hemicolectomy and adjuvant chemotherapy (Capecitabine and Bevacizumab). She developed painless obstructive jaundice of sudden onset. Computed tomography (CT) showed an ampullary nodule with secondary dilatation of the biliary and the pancreatic ducts. Subsequent duodenoscopy and endoscopic ultrasound identified the presence of multiple 3-10 mm tumor-like nodules from the first to the second duodenal knee, the largest one infiltrating the papillary area and preventing its cannulation...
January 23, 2024: Revista Española de Enfermedades Digestivas
#38
JOURNAL ARTICLE
Tim R de Back, Jasmijn D G Linssen, Felice N van Erning, Caitlin S E Verbakel, Pascale J M Schafrat, Louis Vermeulen, Ignace de Hingh, Dirkje W Sommeijer
BACKGROUND: Small intestinal adenocarcinomas (SIAs) are rare. Hence, randomized controlled trials are lacking and understanding of the disease features is limited. This nationwide cohort investigates incidence, treatment and prognosis of SIA patients, to improve disease outcome. PATIENTS AND METHODS: Data of 2697 SIA patients diagnosed from January 1999 through December 2019 were retrieved from the Netherlands Cancer Registry and Pathology Archive. Incidence was calculated using the revised European Standardized Rate...
March 2024: European Journal of Cancer
#39
JOURNAL ARTICLE
Yusuke Watanabe, Takaaki Tatsuguchi, Kenjiro Date, Tomohiko Shinkawa, Hirotaka Kuga, Sadafumi Tamiya, Kazuyoshi Nishihara, Toru Nakano
BACKGROUND: Recent advances in chemotherapy and chemoradiotherapy have enabled conversion surgery (CS) to be performed for selected patients with initially unresectable locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Many studies indicate CS might extend the survival of patients with initially unresectable LA PDAC. However, several clinical questions concerning CS remain, such as the optimal preoperative treatment. Carbon-ion radiotherapy (CIRT) is a unique radiotherapy that offers higher biological effectiveness than conventional radiotherapy...
January 11, 2024: Journal of Medical Case Reports
#40
JOURNAL ARTICLE
Kenya Nakamura, Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tomohiko Ikehara, Kentaro Umemura, Atsushi Kamachi, Takamune Goto, Hidenori Tomida, Yoshiyuki Takahashi, Tadanobu Nagaya, Takeji Umemura, Yuji Soejima
BACKGROUND: Juvenile polyposis syndrome (JPS) is an autosomal dominant, inherited disorder characterized by multiple hyperproliferative polyps of the gastrointestinal tract, particularly of the colon, rectum, and stomach. SMAD4 mutations are frequently associated with multiple polyposis of the stomach; the condition causes severe bleeding and hypoproteinemia, which may progress to severe dysplasia and adenocarcinoma formation. We report our experience with the first case of total gastrectomy with pancreaticoduodenectomy following two partial jejunectomies for JPS, who presented with refractory anemia and protein-losing gastroenteropathy due to polyposis of the stomach and duodenum...
January 9, 2024: Surgical Case Reports
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