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https://www.readbyqxmd.com/read/29453165/endoscopic-submucosal-dissection-for-the-diagnosis-and-therapy-of-pedunculated-gastric-cancer-with-prolapse-into-the-duodenal-bulb-a-case-report
#1
Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Tomonori Imakita, Nobuhiro Tsutsui, Yasunobu Kobayashi, Junji Takahashi, Shinya Okada, Masaki Kitajima, Yutaka Suzuki
INTRODUCTION: Preoperative diagnosis of gastric cancer invasion is not always sufficiently accurate. Diagnostic endoscopic submucosal dissection (ESD) can be performed for the purpose of accurate decision making and to avoid partial treatment vs aggressive over-treatment. We present a patient with the gastric cancer with indeterminate pre-operative diagnosis for depth of the invasion. CASE PRESENTATION: A 70-year-old man presented at our hospital because both anti-Helicobacter pylori (Hp) IGG antibody and serum pepsinogen (PG) levels were classified as positive...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29443782/putative-lung-adenocarcinoma-with-epidermal-growth-factor-receptor-mutation-presenting-as-carcinoma-of-unknown-primary-site-a-case-report
#2
Masahiro Yamasaki, Kunihiko Funaishi, Naomi Saito, Ayaka Sakano, Megumu Fujihara, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Nobuyuki Ohashi, Noboru Hattori
RATIONALE: Only a few cases of putative lung adenocarcinoma presenting as carcinoma of unknown primary site (CUP) with epidermal growth factor receptor (EGFR) mutation have been reported, and the efficacy of EGFR-tyrosine kinase inhibitors (TKIs) for these cases is unclear. PATIENT CONCERNS AND DIAGNOSES: A 67-year-old man complained of paresis of the right lower extremity, dysarthria, and memory disturbance. Computed tomography and magnetic resonance imaging showed multiple brain tumors with brain edema and swelling of the left supraclavicular, mediastinal, and upper abdominal lymph nodes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29426621/update-on-the-management-of-helicobacter-pylori-infection-position-paper-from-the-catalan-society-of-digestology
#3
Jordi Sánchez Delgado, Pilar García-Iglesias, Llúcia Titó, Ignasi Puig, Montse Planella, Emili Gené, Joan Saló, Francesc Martínez-Cerezo, Javier Molina-Infante, Javier P Gisbert, Xavier Calvet
More than 30 years after its discovery, Helicobacter pylori (H. pylori) infection remains the most common cause of gastric and duodenal diseases. H. pylori is the leading cause of chronic gastritis, peptic ulcer, gastric MALT lymphoma and gastric adenocarcinoma. Several consensuses have recently been published on the management of H. pylori infection. The general guidelines of the Spanish consensus, the Toronto Consensus and the Maastricht V Consensus of 2016 are similar but concrete recommendations can vary significantly...
February 6, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29398874/intraductal-papillary-bile-duct-adenocarcinoma-and-gastrointestinal-stromal-tumor-in-a-case-of-neurofibromatosis-type-1
#4
Jung Min Lee, Jae Min Lee, Jong Jin Hyun, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Chang Duck Kim, Dong Sik Kim, Joo Young Kim
We report our experience with a synchronous case of gastrointestinal stromal tumor (GIST) and intraductal papillary neoplasm of the bile duct (IPNB) in an elderly woman with neurofibromatosis type 1 (NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography (CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29394848/-a-case-of-urothelial-carcinoma-who-underwent-pancreaticoduodenectomy-and-was-diagnosed-with-groove-pancreatitis-and-preoperatively-suffered-from-duodenal-stenosis
#5
Daisuke Takiuchi, Osakuni Morimoto, Ryohei Wada, Masaya Higashiguchi, Takashi Nonoshita, Kentaro Nishida, Noriko Wada, Kazuya Sakata, Yusuke Akamaru, Hirofumi Ota, Kunitaka Shibata, Hirotsugu Ohashi
We report a case of a highly advanced urothelial carcinoma accompanied by duodenal stenosis with pancreaticoduodenectomy. A6 6-year-old man presented with upper abdominal pain and vomiting. Acute pancreatitis and hydronephrosis were diagnosed with urgent hospitalization, but jaundice appeared, and stenosis of the duodenum was also found. Thus, we suspected groove pancreatitis or pancreatic cancer, and performed pancreaticoduodenectomy. However, poorly differentiated adenocarcinoma was observed in the retroperitoneal dissection surface in the intraoperative rapid tissue and right hemicolectomy, right nephrectomy, and right ureteral resection were added to the diagnosis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394742/-a-case-of-duodenal-cancer-with-familial-adenomatous-polyposis
#6
Takafumi Yachi, Taiichi Wakiya, Keinosuke Ishido, Daisuke Kudo, Norihisa Kimura, Kenichi Hakamada
A 34-year-old man was diagnosed with familial adenomatous polyposis(FAP)in September 2011, and he underwent endoscopic mucosal resection(EMR)due to multiple polyps in the duodenum and small intestine. Three months later, duodenal cancer was found, and he underwent a subsequent EMR. The pathological findings showed residual cancer cells in the lateral margin; therefore, EMR was performed again. Total colectomy and partial resection of the small intestine was performed in December 2012. Esophagogastroduodenoscopy(EGD)was then performed every 3-6 months, and EMR was performed 4 times...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394561/-a-case-of-surgical-resection-of-a-combined-hepatocellular-and-cholangiocarcinoma-with-hemobilia-from-intraductal-tumor-thrombus
#7
Kazuhito Uemura, Hiroaki Takahashi, Kazuhiro Mino, Takuji Ota, Shunsuke Shichi
We report a case of combined hepatocellular and cholangiocarcinoma with hemobilia. A 65-year-old man was admitted to our hospital because of pain in the right hypochondralrigion. Abdominal ultrasonography revealed bile duct dilatation in the lateral segment of liver and blood test findings showed elevation of the hepatobiliary enzyme, so ERC was performed and hemorrhage from the duodenal papilla was observed. In cholangiography, dilation of the left hepatic bile duct and filling defect were observed, and in the peroral cholangioscopy, a hemorrhagic papillary elevated lesion was identified in the left hepatic bile duct and diagnosed as adenocarcinoma as a result of biopsy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394538/-a-case-of-synchronous-triple-cancer-of-the-breast-duodenal-and-lung
#8
Koji Takada, Shinichiro Kashiwagi, Ryosuke Amano, Wataru Goto, Yuka Asano, Go Ohira, Kenjiro Kimura, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
A 71-year-old woman visited her nearby hospital because jaundice and right hypochondralgia. She was diagnosed as obstructive jaundice due to duodenal papillary carcinoma and was introduced to our hospital. Chest computed tomography showed some tumors in both lung and left breast, then the breast tumor was diagnosed as primary breast cancer by needle biopsy. Since it was difficult to distinguish whether multiple tumor of lung was primary lung cancer or metastasis, right pulmonary partial resection using a thoracoscope was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29392602/-duodenal-adenocarcinoma-giving-rise-to-rectal-metastasis-a-rare-disease-with-an-extremely-rare-metastatic-pattern
#9
Cynthia Epskamp, C H J van Eijck, R H J A Sinke, P Hamberg
No abstract text is available yet for this article.
February 2, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29331402/tailored-surgical-treatment-of-duodenal-polyposis-in-familial-adenomatous-polyposis-syndrome
#10
Toms Augustin, Maitham A Moslim, Andrew Tang, R Matthew Walsh
BACKGROUND: To review our experience in patients undergoing operative treatment for duodenal polypoisis associated with familial adenomatous polyposis with an emphasis on operative approach and long-term outcomes. METHODS: Duodenal polypoisis associated with familial adenomatous polyposis patients undergoing operative treatment were studied retrospectively excluding patients with preoperative duodenal cancer. RESULTS: Of 767 patients in the database, 63 (8...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29309817/a-novel-synthetic-human-insulin-super-promoter-for-targeting-pdx-1-expressing-pancreatic-cancer
#11
Shi-He Liu, Juehua Yu, Robbi Sanchez, Xiaochen Liu, David Heidt, James Willey, John Nemunaitis, Francis Charles Brunicardi
Our previous studies have shown that a rat insulin promoter II fragment (RIP) was used to effectively target pancreatic adenocarcinoma (PDAC) and insulinoma that over-express pancreatic and duodenal homeobox-1 (PDX-1). To enhance the activity and specificity of the human insulin promoter, we engineered a synthetic human insulin super-promoter (SHIP). Reporter assay demonstrated that SHIP1 was the most powerful promoter among all of the SHIPs and had far greater activity than the endogenous human insulin promoters and RIP in PDAC expressing PDX-1...
January 5, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29307199/pathologic-classification-of-pancreatic-cancers-current-concepts-and-challenges
#12
Mohamed E Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29302375/laparoscopic-reinforcement-suture-lars-on-staple-line-of-duodenal-stump-using-barbed-suture-in-laparoscopic-gastrectomy-for-gastric-cancer-a-prospective-single-arm-phase-ii-study
#13
Min Chan Kim, Sang Yun Kim, Kwan Woo Kim
Purpose: Laparoscopic gastrectomy is accepted as a standard treatment for patients with early gastric cancer in Korea, Japan, and China. However, duodenal stump leakage remains a fatal complication after gastrectomy. We conducted a prospective phase II study to evaluate the safety of the new technique of laparoscopic reinforcement suture (LARS) on the duodenal stump. Materials and Methods: The estimated number of patients required for this study was 100 for a period of 18 months...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29290919/cystic-metastasis-from-a-mucinous-adenocarcinoma-of-duodenum-mimicking-type-ii-choledochal-cyst-a-case-report
#14
Yo Na Kim, Ji Soo Song
A 51-year-old male patient was referred to our hospital because of an incidentally detected cystic mass near the common bile duct (CBD). Imaging studies demonstrated a cystic mass that was suspected to communicate with the CBD. Gastroscopy showed irregular mucosal thickening with hyperemic change in the second portion of the duodenum. A type II choledochal cyst combined with duodenal malignancy was suspected. The patient underwent surgical resection and the histological diagnosis was mucinous adenocarcinoma of the duodenum with cystic metastasis...
December 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29281782/duodenal-adenocarcinoma-of-brunner-gland-origin-a-case-report
#15
Ji Hye Moon, Kyoungbun Lee, Han-Kwang Yang, Woo Ho Kim
We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelimmnto adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium...
December 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29260430/effect-of-postoperative-radiotherapy-on-survival-in-duodenal-adenocarcinoma-a-propensity-score-adjusted-analysis-of-surveillance-epidemiology-and-end-results-database
#16
Yu Jin Lim, Kyubo Kim
PURPOSE: The use of adjuvant treatment has not been sufficiently investigated in duodenal adenocarcinoma. This study evaluated the effect of postoperative radiotherapy (PORT) on survival outcomes in this rare malignancy. METHODS: We identified patients who were diagnosed between 2004 and 2013 in the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and disease-specific survival (DSS) were analyzed before and after propensity score matching...
December 19, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29259073/phase-ii-study-of-panitumumab-in-ras-wild-type-metastatic-adenocarcinoma-of-small-bowel-or-ampulla-of-vater
#17
Pat Gulhati, Kanwal Raghav, Rachna Shroff, Gauri Varadhachary, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert Wolff, Michael J Overman
LESSONS LEARNED: Panitumumab has no clinical activity in metastatic RAS wild-type small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC), possibly due to the foregut and midgut derivation of small bowel and ampulla.These results, along with findings from genomic characterization of SBA, suggest that SBA represents a unique intestinal malignancy and treatments should not be habitually extrapolated from colorectal cancer.Further studies evaluating the benefit of targeted therapies exclusively in SBA and AAC are warranted...
December 19, 2017: Oncologist
https://www.readbyqxmd.com/read/29245220/case-report-of-intestinal-non-rotation-heterotaxy-and-polysplenia-in-a-patient-with-pancreatic-cancer
#18
Spyridon Pagkratis, Sara Kryeziu, Miranda Lin, Samah Hoque, Juan Carlos Bucobo, Jonathan M Buscaglia, Georgios V Georgakis, Aaron R Sasson, Joseph Kim
RATIONALE: Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly complex. This case report demonstrates successful pancreatic cancer resection despite the patient's complicated anatomy. PATIENT CONCERNS: An 82-year-old female presented to our institution with complaints of mild right upper quadrant pain radiating to the mid-epigastric region...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29224265/-analysis-on-the-clinical-therapeutic-effects-of-arterial-first-approach-pancreatoduodenectomy-in-the-treatment-of-borderline-resectable-pancreatic-adenocarcinoma
#19
G Jin, K L Zheng, S W Guo, Z Shao, C Liu, X H Shi, R D Liu, S J Bai, H Jiang, Y Bian, X G Hu
Objective: To compare the clinical therapeutic effects of arterial first approach pancreaticoduodenectomy(AFA-PD) with standard approach pancreaticoduodenectomy(SPD) in the treatment of borderline resectable pancreatic cancer (BRPC). Methods: A retrospective analysis of the clinical data of 113 cases of pancreatic cancer patients from January 2014 to August 2015 at Department of Hepato-Biliary-Pancreatic Surgery, Changhai Hospital, the Second Military Medical University, including 43 cases in AFA-PD group and 70 cases in SPD group...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29207718/an-alpha-fetoprotein-producing-gastric-tumor-with-yolk-sac-hepatoid-and-papillary-adenocarcinoma-components
#20
Archana Lakshmanan, Ann Kurian, Annapurneswari Subramanyan, Ayyappan Srinivasan
Alpha Fetoprotein (AFP) producing gastric carcinomas are very rare and have unique clinicopathological features and an extremely poor prognosis. Here, we report a case of AFP producing gastric carcinoma with three distinct histomorphologic patterns such as yolk sac like, hepatoid, tubular and papillary adenocarcinoma components. The uniqueness of this case is absence of metastases and associated findings such as fundic gland polyposis with varying degrees of dysplasia, gastric and duodenal well differentiated neuroendocrine tumour and rectal ganglioneuroma...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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