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duodenal adenocarcinoma

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https://www.readbyqxmd.com/read/27900107/preclinical-trial-on-the-use-of-doxycycline-for-the-treatment-of-adenocarcinoma-of-the-duodenum
#1
Hector R Galván-Salazar, Alejandro D Soriano-Hernández, Daniel A Montes-Galindo, Gabriel Ceja Espíritu, José Guzman-Esquivel, Iram P Rodríguez-Sánchez, Oscar A Newton-Sánchez, Margarita L Martinez-Fierro, Xóchitl G Briseño Gómez, Augusto Rojas-Martínez, Iván Delgado-Enciso
Adenocarcinoma of the duodenum comprises 50-70% of duodenal tumors. There is an increase in extracellular matrix metalloproteinases in this disease and it has been suggested that they play an important role in the development and pathology. Therefore, new therapeutic recommendations based on inhibitors of these enzymes, such as doxycycline, are under investigation. The cytotoxic effect of doxycycline was evaluated in the HuTu-80 duodenal adenocarcinoma cell line and its antitumor effect was determined in an immunodeficient murine model...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27886029/prevalence-of-h-pylori-in-gastric-biopsy-specimen-in-the-southeastern-region-of-turkey
#2
Fulya Bayındır Bilman, Mehmet Özdemir, Birol Baysal, Muhammed Güzel Kurtoğlu
INTRODUCTION: Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes human gastric mucosa. Gastric ulcer, duodenal ulcer, chronic atrophic gastritis, mucosa-associated lymphoid tissue lymphoma, and stomach adenocarcinoma are associated with H. pylori as the etiological agent. Cytotoxin-associated gene A (cagA), which is one of the most important virulence factors of H. pylori, encodes a 120-145 kDa protein. The prevalence of cagA genes shows differences in H...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27880934/tumors-with-unmethylated-mlh1-and-the-cpg-island-methylator-phenotype-are-associated-with-a-poor-prognosis-in-stage-ii-colorectal-cancer-patients
#3
Tao Fu, Yanliang Liu, Kai Li, Weiwei Wan, Emmanouil P Pappou, Christine A Iacobuzio-Donahue, Zachary Kerner, Stephen B Baylin, Christopher L Wolfgang, Nita Ahuja
We previously developed a novel tumor subtype classification model for duodenal adenocarcinomas based on a combination of the CpG island methylator phenotype (CIMP) and MLH1 methylation status. Here, we tested the prognostic value of this model in stage II colorectal cancer (CRC) patients. Tumors were assigned to CIMP+/MLH1-unmethylated (MLH1-U), CIMP+/MLH1-methylated (MLH1-M), CIMP-/MLH1-U, or CIMP-/MLH1-M groups. Age, tumor location, lymphovascular invasion, and mucin production differed among the four patient subgroups, and CIMP+/MLH1-U tumors were more likely to have lymphovascular invasion and mucin production...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27866532/-evaluation-of-disease-free-survival-after-radical-resection-for-primary-duodenal-adenocarcinoma
#4
Q L Jiang, X H Huang, J W Zhang, S S Zhang, C F Wang
Objective: To investigate the risk factors associated with the disease free survival (DFS) for primary duodenal adenocarcinoma patients undergoing radical resection. Methods: The clinicopathological data of 101 primary duodenal adenocarcinoma patients who underwent radical resection from January 2001 to October 2014 were retrospectively reviewed. Using SPSS 13.0 software, the survival curve was drawn by Kaplan-Meier method, and the survival rates were analyzed by Log-rank test.COX regression model was used to identify independent risk factors...
November 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27859010/bevacizumab-combined-with-capecitabine-and-oxaliplatin-in-patients-with-advanced-adenocarcinoma-of-the-small-bowel-or-ampulla-of-vater-a-single-center-open-label-phase-2-study
#5
Pat Gulhati, Kanwal Raghav, Rachna T Shroff, Gauri R Varadhachary, Scott Kopetz, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert A Wolff, Michael J Overman
BACKGROUND: Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS: In this phase 2, single-arm, single-center, open-label study, patients aged ≥18 years with untreated, advanced SBA or AAC were recruited. Patients received capecitabine at a dose of 750 mg/m(2) orally twice daily on days 1 to 14, oxaliplatin at a dose of 130 mg/m(2) intravenously on day 1, and bevacizumab at a dose of 7...
November 14, 2016: Cancer
https://www.readbyqxmd.com/read/27822957/duodenal-stump-recurrence-of-gastric-adenocarcinoma-after-subtotal-gastrectomy
#6
Armando Peixoto, João Santos-Antunes, Marco Silva, Guilherme Macedo
The authors present the case of a 71-year-old man with a history of a Billroth-II subtotal gastrectomy due to a mixed adenocarcinoma, stage pT4aN3aM0 (TNM classification), with adjuvant chemotherapy. Subsequent endoscopic and imaging evaluations revealed no signs of recurrence. Five years later, the patient was admitted with obstructive jaundice.
November 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27821316/lymph-node-evaluation-and-survival-after-curative-intent-resection-of-duodenal-adenocarcinoma-a-matched-cohort-study
#7
B L Ecker, M T McMillan, J Datta, D T Dempsey, G C Karakousis, D L Fraker, J A Drebin, R Mamtani, B J Giantonio, R E Roses
BACKGROUND: Lymph node (LN) metastasis in patients with duodenal adenocarcinoma is associated with poor prognosis; however, the optimal extent of LN assessment and the interaction between LN assessment and adjuvant systemic therapy is poorly understood. METHODS: Resected non-metastatic duodenal adenocarcinoma patients (n = 1743) were identified in the National Cancer Database (1998-2011). Logistic regression analysis identified covariates associated with LN metastasis...
November 4, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27821077/a-case-series-of-intestinal-adenomatous-polyposis-of-unidentified-etiology-a-late-effect-of-irradiation
#8
Lisanne Sara Rigter, Frank G J Kallenberg, Barbara Bastiaansen, Theo A M van Os, Floor E van Leeuwen, Monique Esther van Leerdam, Evelien Dekker
BACKGROUND: In a large number of patients with multiple gastrointestinal adenomatous polyps, no causal germline mutation can be found. Non-genetic factors may contribute to the development of adenomatous polyps in these unexplained polyposis patients. In the development of gastrointestinal cancer, prior exposure to abdominal radiotherapy has been identified as such a factor, as it increases the gastrointestinal cancer risk in cancer survivors. A relationship of radiotherapy with intestinal polyposis, however, has not yet been described...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27817166/acute-obstructive-pancreatitis-after-pancreas-sparing-total-duodenectomy-in-a-patient-with-pancreas-divisum-a-case-report
#9
Shimpei Otsuka, Teiichi Sugiura, Katsuhiko Uesaka
BACKGROUND: Pancreas-sparing total duodenectomy (PSTD) is an ideal recommended procedure for patients with multiple duodenal adenomas or early duodenal cancer. We herein report a rare but serious complication of PSTD. CASE PRESENTATION: A 20-year-old woman with duodenal adenocarcinoma underwent PSTD. On postoperative day one, she complained of severe abdominal pains. Her serum amylase and serum pancreatic amylase levels were extremely elevated (Amy, 1296 IU/L; P-Amy, 1273 IU/L)...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27739441/non-ampullary-duodenal-carcinomas-clinicopathologic-analysis-of-47-cases-and-comparison-with-ampullary-and-pancreatic-adenocarcinomas
#10
Yue Xue, Alessandro Vanoli, Serdar Balci, Michelle M Reid, Burcu Saka, Pelin Bagci, Bahar Memis, Hyejeong Choi, Nobuyike Ohike, Takuma Tajiri, Takashi Muraki, Brian Quigley, Bassel F El-Rayes, Walid Shaib, David Kooby, Juan Sarmiento, Shishir K Maithel, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
Literature on non-ampullary-duodenal carcinomas is limited. We analyzed 47 resected non-ampullary-duodenal carcinomas. Histologically, 78% were tubular-type adenocarcinomas mostly gastro-pancreatobiliary type and only 19% pure intestinal. Immunohistochemistry (n=38) revealed commonness of 'gastro-pancreatobiliary markers' (CK7 55, MUC1 50, MUC5AC 50, and MUC6 34%), whereas 'intestinal markers' were relatively less common (MUC2 36, CK20 42, and CDX2 44%). Squamous and mucinous differentiation were rare (in five each); previously, unrecognized adenocarcinoma patterns were noted (three microcystic/vacuolated, two cribriform, one of comedo-like, oncocytic papillary, and goblet-cell-carcinoid-like)...
October 14, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27732711/association-of-histopathologic-phenotype-of-periampullary-adenocarcinomas-with-survival
#11
Jennifer L Williams, Carmen K Chan, Paul A Toste, Irmina A Elliott, Charles R Vasquez, Dharma B Sunjaya, Eric A Swanson, Jamie Koo, O Joe Hines, Howard A Reber, David W Dawson, Timothy R Donahue
Importance: Patients with periampullary adenocarcinomas have widely variable survival. These cancers are traditionally categorized by their anatomic location of origin, namely, the duodenum, ampulla, distal common bile duct (CBD), or head of the pancreas. However, they can be alternatively subdivided histopathologically into intestinal or pancreaticobiliary (PB) types, which may more accurately estimate prognosis. Objectives: To identify factors associated with survival in patients with periampullary adenocarcinomas and to compare survival between those having intestinal-type or PB-type cancers originating from the duodenum, ampulla, or distal CBD with those having pancreatic ductal adenocarcinoma (PDAC)...
October 12, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27723690/-total-pancreatectomy-for-pancreatic-cancer
#12
Yu I Patyutko, N E Kudashkin, A G Kotel'nikov, O V Chistyakova
AIM: to determine the indications and to evaluate early and long-term outcomes of total pancreatectomy for pancreatic cancer. MATERIAL AND METHODS: Treatment of 29 patients who underwent one- and two-stage pancreatectomy for different malignancies was analyzed. RESULTS: Median of surgery duration and intraoperative blood loss was 280 min and 2200 ml respectively. Postoperative complications were observed in 9 (31%) patients. There were 2 (6...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27713775/diet-and-helicobacter-pylori-infection
#13
Łukasz Hołubiuk, Jacek Imiela
Helicobacter pylori infection has accompanied man for thousands of years. In some infected patients, a complex and dynamic pathogen-host reaction triggers pathogenic pathways resulting in development, inter alia, of atrophic gastritis, peptic ulcer disease (both gastric and duodenal), gastric adenocarcinoma, and MALT lymphoma. Large-scale eradication therapy is associated with a rapid increase in antibiotic resistance, gut flora composition disturbances, and increased risk of development, inter alia, of paediatric infectious diarrhoeas, atopic diseases, and oesophageal adenocarcinoma...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27708554/individually-optimized-stereotactic-radiotherapy-for-pancreatic-head-tumors-a-planning-feasibility-study
#14
Milly Buwenge, Savino Cilla, Alessandra Guido, Lucia Giaccherini, Gabriella Macchia, Francesco Deodato, Silvia Cammelli, Francesco Cellini, Gian C Mattiucci, Vincenzo Valentini, Markus Stock, Alessio G Morganti
AIM: Aim of this study was to perform a planning feasibility analysis of a 3-level dose prescription using an IMRT-SIB technique. BACKGROUND: Radiation therapy of locally advanced pancreatic cancer should administer a minimum dose to the duodenum and a very high dose to the vascular infiltration areas to improve the possibility of a radical resection. MATERIALS AND METHODS: Fifteen patients with pancreatic head adenocarcinoma and vascular involvement were included...
November 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27688667/case-of-a-tumor-comprising-gastric-cancer-and-duodenal-neuroendocrine-tumor
#15
Hiroaki Kaneko, Akio Miyake, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda
The present report describes a rare case of a tumor composed of early gastric cancer and a duodenal neuroendocrine tumor (NET). A 78-year-old woman underwent esophagogastroduodenoscopy at a local institution for screening of the upper gastrointestinal tract which revealed a protruded tumor through the pyloric ring from the pyloric antrum. The tumor was too large to treat at the facility; consequently, she was referred to our hospital for further management. Esophagogastroduodenoscopy with tumor biopsy of the lesion revealed the diagnosis of early gastric cancer...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27643594/methylation-of-mgmt-is-associated-with-poor-prognosis-in-patients-with-stage-iii-duodenal-adenocarcinoma
#16
Tao Fu, Anup Sharmab, Fei Xie, Yanliang Liu, Kai Li, Weiwei Wan, Stephen B Baylin, Christopher L Wolfgang, Nita Ahuja
BACKGROUND: O6-methylguanine-DNA methyltransferase (MGMT) methylation status has not been extensively investigated in duodenal adenocarcinoma (DA). The aim of this study was to evaluate the MGMT methylation status and examine its possible prognostic value in patients with stage III DA. METHODS: Demographics, tumor characteristics and survival were available for 64 patients with stage III DA. MGMT methylation was detected by using MethyLight. A Cox proportional hazard model was built to predict survival, adjusted for clinicopathological characteristics and tumor molecular features, including the CpG island methylator phenotype (CIMP), microsatellite instability (MSI), and KRAS mutations...
2016: PloS One
https://www.readbyqxmd.com/read/27603299/pancreaticoduodenectomy-for-nonampullary-duodenal-lesions-indications-and-results
#17
Awad Shamali, Raymond McCrudden, Pradeep Bhandari, Fanny Shek, Emily Barnett, Adrian Bateman, Mohammed Abu Hilal
BACKGROUND: Pancreaticoduodenectomy (PD) is a complex procedure, associated with a definite risk of mortality and 30-50% risk of complications. For nonampullary duodenal lesions, PD can carry a higher morbidity as they are more commonly associated with a soft pancreas and narrow-calibre main pancreatic ducts. It is therefore paramount that the risks and benefits of surgery are considered carefully in this group of patients. A preoperative histological diagnosis for duodenal lesions is normally achieved by endoscopic biopsy...
September 3, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27600057/anisakidosis-a-fortuitous-mimicker-of-gastrointestinal-malignancy
#18
Mohammad Qasim Khan, Jonathan Williams
A 51-year-old woman presented with epigastric pain, vomiting and diarrhoea. Her sister was recently diagnosed with duodenal adenocarcinoma, manifesting similar symptoms. Imaging revealed thickened gastric antrum with enlarged local lymph nodes. Endoscopy illustrated 3 worms embedded in the antral wall, identified as Anisakis simplex larvae. Larvae removal and a 2-week albendazole regimen treated the symptoms. With globalisation of cultural culinary practices, physicians must be vigilant of anisakidosis. Its ability to mimic peptic ulcer disease, chronic gastritis and malignancy necessitates broader differential diagnoses and lower thresholds for endoscopy...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27549598/invasion-depth-measured-in-millimeters-is-a-predictor-of-survival-in-patients-with-distal-bile-duct-cancer-decision-tree-approach
#19
Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Eun-Kyung Kim, Sang Bong Ahn, Seong Hwan Kim, Yun Ju Jo, Young Sook Park, Jinwon Seo, Young Ha Oh, Sukjoong Oh, Ho Young Kim, Mi Jung Kwon, Soo Kee Min, Hye-Rim Park, Ji-Young Choe, Jang Yong Jeon, Hong Il Ha, Jung Woo Lee
BACKGROUND: AJCC staging system is unreliable for predicting survival in distal bile duct (DBD) cancer patients, due to inter-observer variation. Measured depth of invasion (DOI) is suggested to be more accurate to predict patients' clinical outcome in extra-hepatic cholangiocarcinomas, but its significance in DBD cancer and cutoff values are still debatable. This study aimed to identify the optimal cutoff value of DOI in relation to prognosis in DBD cancer patients. METHODS: Data of 179 patients with DBD adenocarcinoma treated in three institutions were investigated...
August 22, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27540449/development-and-diagnostic-evaluation-of-loop-mediated-isothermal-amplification-using-a-new-gene-target-for-rapid-detection-of-helicobacter-pylori
#20
Somaye Bakhtiari, Amirhooshang Alvandi, Hamid Pajavand, Jafar Navabi, Farid Najafi, Ramin Abiri
BACKGROUND: Helicobacter pylori cause chronic gastritis and subsequent diseases like gastric and duodenal ulcers and gastric adenocarcinoma. Current methods for detecting H. pylori have several disadvantages and it is of utmost importance to develop a simple, quick, accurate, and cost-effective diagnostic test. OBJECTIVES: The aim of this study was to set up and evaluate a diagnostic value of loop- mediated isothermal amplification (LAMP) for detecting H. pylori...
May 2016: Jundishapur Journal of Microbiology
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