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REVIEW
Clare England, David Jarrom, Jennifer Washington, Elise Hasler, Leona Batten, Adrian Edwards, Ruth Lewis
BACKGROUND: Cost-of-living crises are damaging to population mental health and require a public health response. It is important to assess whether public health interventions are effective. We aimed to identify population-level methods and measures and the appropriateness of the measures for vulnerable populations. METHODS: A rapid evidence review was undertaken. Nineteen databases, including grey literature, were searched for evidence published between 1970 and April 2023...
April 4, 2024: Health Policy
#2
Sudipta Chakrabarti, Sujyoti Chandra, Avik Roy, Madhuchhanda Kundu, Kalipada Pahan
No abstract text is available yet for this article.
March 27, 2024: Neurobiology of Disease
#3
REVIEW
Christina R Whitehouse, Samuel Akyirem, Christopher Petoskey, Shuyuan Huang, Dora Lendvai, Janene Batten, Robin Whittemore
PURPOSE: The purpose of this study is to systematically review interventions that address food insecurity for persons with prediabetes or type 2 diabetes using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework. METHODS: Six databases (OVIDMEDLINE, OVIDEMBASE, OVID APA PsycINFO, Web of Science, Cochrane Central Registry of Controlled Trials, and EBSCO CINAHL Complete) were searched through January 2023. Research team members independently performed screening of abstracts and full texts, data abstraction, and risk assessment...
March 28, 2024: The science of diabetes self-management and care
#4
JOURNAL ARTICLE
Matthew O'Neal, Ines Noher de Halac, Shawn C Aylward, Vedat Yildiz, Bianca Zapanta, Nicolas Abreu, Emily de Los Reyes
BACKGROUND: Mutations in the CLN6 gene cause late infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disease of childhood onset. Clinically, individuals present with progressive motor and cognitive regression, ataxia, and early death. The aim of this study is to establish natural history data of individuals with classic, late-infantile-onset (age less than five years) CLN6 disease. METHODS: We analyzed the natural history of 25 patients with late-infantile-onset CLN6, utilizing the Hamburg motor-language scale to measure disease progression...
March 1, 2024: Pediatric Neurology
#5
JOURNAL ARTICLE
Kristina Crothers, Scott V Adams, Aaron P Turner, Lisa Batten, Reyhaneh Nikzad, John R Kundzins, Vincent S Fan
INTRODUCTION: Chronic lung disease (CLD) has been associated with risk for more severe manifestations and death with COVID-19. However, few studies have evaluated the risk overall and by type of CLD for severity of COVID-19 outcomes in a US national cohort. METHODS: Using data from the Veterans Health Administration, we determined the risk associated with CLDs including COPD (mild/severe), asthma (mild/active/severe), idiopathic pulmonary fibrosis (IPF), sarcoidosis and other interstitial lung diseases (ILDs) for outcomes among veterans with SARS-CoV-2 positive tests between 3/1/2020-4/30/2021...
March 26, 2024: Annals of the American Thoracic Society
#6
JOURNAL ARTICLE
Rachel R Reith, Mackenzie C Batt, Anna M Fuller, Jessica M Meekins, Kathryn A Diehl, You Zhou, Patrick S Bedwell, Jack A Ward, Stacy K Sanders, Jessica L Petersen, David J Steffen
Thirteen American Hereford cattle were reported blind with presumed onset when ~12-mo-old. All blind cattle shared a common ancestor through both the maternal and paternal pedigrees, suggesting a recessive genetic origin. Given the pedigree relationships and novel phenotype, we characterized the ophthalmo-pathologic changes associated with blindness and identified the responsible gene variant. Ophthalmologic examinations of 5 blind cattle revealed retinal degeneration. Histologically, 2 blind cattle had loss of the retinal photoreceptor layer...
March 22, 2024: Journal of Veterinary Diagnostic Investigation
#7
JOURNAL ARTICLE
Lynnette C Goatley, Graham Freimanis, Chandana Tennakoon, Thomas J Foster, Mehnaz Quershi, Linda K Dixon, Carrie Batten, Jan Hendrik Forth, Abel Wade, Christopher Netherton
African swine fever (ASF) is a devastating disease of domestic pigs that has spread across the globe since its introduction into Georgia in 2007. The etiological agent is a large double-stranded DNA virus with a genome of 170 to 180 kb in length depending on the isolate. Much of the differences in genome length between isolates are due to variations in the copy number of five different multigene families that are encoded in repetitive regions that are towards the termini of the covalently closed ends of the genome...
2024: PloS One
#8
JOURNAL ARTICLE
Angela Schulz, Nita Patel, Jon J Brudvig, Frank Stehr, Jill M Weimer, Erika F Augustine
BACKGROUND: CLN3 disease (also known as CLN3 Batten disease or Juvenile Neuronal Ceroid Lipofuscinosis) is a rare pediatric neurodegenerative disorder caused by biallelic mutations in CLN3. While extensive efforts have been undertaken to understand CLN3 disease etiology, pathology, and clinical progression, little is known about the impact of CLN3 disease on parents and caregivers. Here, we investigated CLN3 disease progression, clinical care, and family experiences using semi-structured interviews with 39 parents of individuals with CLN3 disease...
March 18, 2024: Orphanet Journal of Rare Diseases
#9
JOURNAL ARTICLE
Ana C Puhl, Renuka Raman, Tammy M Havener, Eni Minerali, Anthony J Hickey, Sean Ekins
Palmitoyl-protein thioesterase 1 (PPT1) is an understudied enzyme that is gaining attention due to its role in the depalmitoylation of several proteins involved in neurodegenerative diseases and cancer. PPT1 is overexpressed in several cancers, specifically cholangiocarcinoma and esophageal cancers. Inhibitors of PPT1 lead to cell death and have been shown to enhance the killing of tumor cells alongside known chemotherapeutics. PPT1 is hence a viable target for anticancer drug development. Furthermore, mutations in PPT1 cause a lysosomal storage disorder called infantile neuronal ceroid lipofuscinosis (CLN1 disease)...
March 12, 2024: ACS Omega
#10
JOURNAL ARTICLE
Norberto Guelbert, Oscar Mauricio Espitia Segura, Carolina Amoretti, Angélica Arteaga Arteaga, Nora Graciela Atanacio, Sabrina Bazan Natacha, Ellaine Doris Fernandes Carvalho, Maria Denise Fernandes Carvalho de Andrade, Inés María Denzler, Consuelo Durand, Erlane Ribeiro, Juan Carlos Giugni, Gabriel González, Dolores González Moron, Guillermo Guelbert, Zulma Janneth Hernández Rodriguez, Katiane Embiruçu Emilia, Marcelo Andrés Kauffman, Nury Isabel Mancilla, Laureano Marcon, Alessandra Marques Pereira, Carolina Fischinger Moura de Souza, Victor Adrián Muñoz, Ricardo Andrés Naranjo Flórez, André Luiz Pessoa, María Victoria Ruiz, Martha Luz Solano Villareal, Norma Spécola, Lina Marcela Tavera, Javiera Tello, Mónica Troncoso Schifferli, Sonia Ugrina, María Magdalena Vaccarezza, Diane Vergara, María Mercedes Villanueva
INTRODUCTION: Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), is a neurodegenerative autosomal recessive disease caused by TPP1 gene variants , with a spectrum of classic and atypical phenotypes. The aim of treatment is to slow functional decline as early as possible in an attempt to improve quality of life and survival. This study describes the clinical characteristics as well as the response to treatment with cerliponase alfa. MATERIALS AND METHODS: A retrospective study was conducted in five Latin-American countries, using clinical records from patients with CLN2...
March 2024: Molecular Genetics and Metabolism Reports
#11
JOURNAL ARTICLE
Hayley Bennett, Christopher Rao, Leona Batten, Elise Hasler, David Jarrom, Matthew Prettyjohns, Craig Barrington, Arthur Sun Myint
AIM: Health Technology Wales sought to evaluate the clinical and cost-effectiveness of contact X-ray brachytherapy (CXB) for early-stage rectal cancer. METHODS: Relevant studies were identified through systematic searches of MEDLINE, Embase, Cochrane Library and Scopus. A cost-utility model was developed to estimate the cost-effectiveness of CXB in National Health Service Wales, using results of the Organ Preservation in Early Rectal Adenocarcinoma (OPERA) trial...
March 11, 2024: Colorectal Disease
#12
JOURNAL ARTICLE
Kwamina Nyame, Andy Hims, Aya Aburous, Nouf N Laqtom, Wentao Dong, Uche N Medoh, Julia C Heiby, Jian Xiong, Alessandro Ori, Monther Abu-Remaileh
Batten disease, the most prevalent form of neurodegeneration in children, is caused by mutations in the CLN3 gene, which encodes a lysosomal transmembrane protein. CLN3 loss leads to significant accumulation of glycerophosphodiesters (GPDs), the end products of glycerophospholipid catabolism in the lysosome. Despite GPD storage being robustly observed upon CLN3 loss, the role of GPDs in neuropathology remains unclear. Here, we demonstrate that GPDs act as potent inhibitors of glycerophospholipid catabolism in the lysosome using human cell lines and mouse models...
February 28, 2024: Molecular Cell
#13
JOURNAL ARTICLE
A Jamshid Sadid, Mohammad Adil Dar, A Fayeq Ghowsi, A Cüneyt Aydın
Previous research on cold-formed steel (CFS) battened columns has identified the critical factors influencing their performance and accordingly, their limiting values for improved performance have been recommended. However, these studies involved connecting battens to the chords (channels) via their flanges, leaving the slenderest component disconnected from the web. This study introduces a novel hooped-batten (tubular-element) that links both webs and flanges of the chords together, thereby improving the structural integrity of the built-up system and curtailing the half-wave buckling length in the webs...
March 2, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Seth R Batten, Dan Bang, Brian H Kopell, Arianna N Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S Barbosa, Thomas Twomey, Terry Lohrenz, Jason P White, Peter Dayan, Alexander W Charney, Martijn Figee, Helen S Mayberg, Kenneth T Kishida, Xiaosi Gu, P Read Montague
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin...
February 26, 2024: Nature Human Behaviour
#15
REVIEW
Laura L Manzo, Rebeccah A Dindinger, Janene Batten, Joan L Combellick, Bridget Basile-Ibrahim
INTRODUCTION: Active-duty servicewomen and veterans make up nearly 20% of the United States military and may experience trauma specific to military service. Military-specific trauma includes combat deployment and military sexual trauma, exposure to which may result in posttraumatic stress disorder (PTSD). The purpose of this scoping review is to examine the extent to which military trauma exposures impact the pregnancy outcomes of active-duty servicewomen and women veterans. METHODS: A systematic search of OVID MEDLINE, OVID Embase, and OVID PsycINFO from inception to September 25, 2023, identified studies examining associations between military trauma exposures and perinatal outcomes...
February 21, 2024: Journal of Midwifery & Women's Health
#16
JOURNAL ARTICLE
Kerry Newbrook, Nakibul Khan, Aimee Fisher, Karen Chong, Simon Gubbins, William C Davies, Christopher Sanders, Marc Guimerà Busquets, Lyndsay Cooke, Amanda Corla, Martin Ashby, John Flannery, Carrie Batten, Jessica E Stokes, Beatriz Sanz-Bernardo, Simon Carpenter, Katy Moffat, Karin E Darpel
INTRODUCTION: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by immunosuppression and substantial lymphopenia at peak viraemia in the host. METHODS: In this study, the role of cell-mediated immunity and specific T-cell subsets in BTV pathogenesis, clinical outcome, viral dynamics, immune protection, and onwards transmission to a susceptible Culicoides vector is defined in unprecedented detail for the first time, using an in vivo arboviral infection model system that closely mirrors natural infection and transmission of BTV...
2024: Frontiers in Immunology
#17
JOURNAL ARTICLE
Shira Maguen, Adam Batten, Sarah E Siegel, Joy Huggins, Jennifer L Snow, Lindsay M Fenn, Alexandra M Dick, Christiane Zenteno, Anna C West, Robin M Masheb
The aim of our study was to validate the Eating Disorder Diagnostic Scale (EDDS-5) updated for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) with a diverse veteran population against a clinician-administered interview based on the Structured Clinical Interview for DSM-5 (SCID-5). Our sample included 343 veterans, 18-75 years, recruited April 2019 to December 2022 who completed the EDDS-5 as well as other eating disorder and mental health measures. A subsample of these veterans received clinical interviews (n = 166), which were used to validate the EDDS-5...
January 23, 2024: Eating Behaviors
#18
JOURNAL ARTICLE
Robert J Huber, William D Kim, Morgan L D M Wilson-Smillie
Ceroid lipofuscinosis neuronal 5 (CLN5) and cathepsin D (CTSD) are soluble lysosomal enzymes that also localize extracellularly. In humans, homozygous mutations in CLN5 and CTSD cause CLN5 disease and CLN10 disease, respectively, which are two subtypes of neuronal ceroid lipofuscinosis (commonly known as Batten disease). The mechanisms regulating the intracellular trafficking of CLN5 and CTSD and their release from cells are not well understood. Here, we used the social amoeba Dictyostelium discoideum as a model system to examine the pathways and cellular components that regulate the intracellular trafficking and release of the D...
January 2024: Traffic
#19
REVIEW
Jasleen K Jolly, Brent M Rodda, Thomas L Edwards, Lauren N Ayton, Jonathan B Ruddle
Recent advances have led to therapeutic options becoming available for people with inherited retinal disease. In particular, gene therapy has been shown to hold great promise for slowing vision loss from inherited retinal disease. Recent studies suggest that gene therapy is likely to be most effective when implemented early in the disease process, making consideration of paediatric populations important. It is therefore necessary to have a comprehensive understanding of retinal imaging in children with inherited retinal diseases, in order to monitor disease progression and to determine which early retinal biomarkers may be used as outcome measures in future clinical trials...
January 22, 2024: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
#20
JOURNAL ARTICLE
Suxiang Chen, Saumya Nishanga Heendeniya, Bao T Le, Kamal Rahimizadeh, Navid Rabiee, Qurat Ul Ain Zahra, Rakesh N Veedu
The last decade (2013-2023) has seen unprecedented successes in the clinical translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have been granted marketing approval by the United States Food and Drug Administration (US FDA) during the decade, after the first ASO drug, fomivirsen, was approved much earlier, in 1998. Splice-modulating ASOs have also been developed for the therapy of inborn errors of metabolism (IEMs), due to their ability to redirect aberrant splicing caused by mutations, thus recovering the expression of normal transcripts, and correcting the deficiency of functional proteins...
January 22, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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