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https://www.readbyqxmd.com/read/29783779/hyperoxia-disrupts-extracellular-signal-regulated-kinases-1-2-induced-angiogenesis-in-the-developing-lungs
#1
Renuka T Menon, Amrit Kumar Shrestha, Roberto Barrios, Binoy Shivanna
Hyperoxia contributes to the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic lung disease of infants that is characterized by interrupted alveologenesis. Disrupted angiogenesis inhibits alveologenesis, but the mechanisms of disrupted angiogenesis in the developing lungs are poorly understood. In pre-clinical BPD models, hyperoxia increases the expression of extracellular signal-regulated kinases (ERK) 1/2; however, its effects on the lung endothelial ERK1/2 signaling are unclear. Further, whether ERK1/2 activation promotes lung angiogenesis in infants is unknown...
May 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29764580/-effect-of-rhubarb-on-neonatal-rats-with-bronchopulmonary-dysplasia-induced-by-hyperoxia
#2
Ling-Ling Yin, Zhen-Zhi Ye, Li-Jun Tang, Liang Guo, Wei-Min Huang
OBJECTIVE: To study the effect of rhubarb on neonatal rats with bronchopulmonary dysplasia (BPD) induced by hyperoxia. METHODS: A total of 64 rats (postnatal day 4) were randomly divided into four groups: air control, rhubarb control, hyperoxia model, and hyperoxia+rhubarb (n=16 each). The rats in the hyperoxia model and hyperoxia+rhubarb groups were exposed to hyperoxia (60% O2) to establish a BPD model. The rats in the rhubarb control and hyperoxia+rhubarb groups were given rhubarb extract suspension (600 mg/kg) by gavage daily...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29764579/-dynamic-expression-and-role-of-sumo-modified-c-ebp-alpha-in-preterm-rats-with-bronchopulmonary-dysplasisa-induced-by-hyperoxia-exposure
#3
Yue Zhu, Hong-Yan Lu, Xiao-Bo Hao, Ming Chang, Qiu-Xia Wang, Feng-Yun Wan, Xue-Qing Wan
OBJECTIVE: To study the expression of SUMO-modified CCAAT enhancer binding protein α (C/EBPα) in preterm rat model of bronchopulmonary dysplasisa (BPD) induced by hyperoxia exposure and its role. METHODS: Eighteen preterm rats were randomly divided into an air group and a hyperoxia group (n=9 each). The model of BPD was prepared in preterm rats exposed to hyperoxia. The rats from the two groups were sacrificed on postnatal days 4, 7 and 14 respectively (3 rats at each time) and lung tissues were harvested...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29763371/normobaric-hyperoxia-inhibits-the-progression-of-lung-cancer-by-inducing-apoptosis
#4
Sei Won Kim, In Kyoung Kim, Jick Hwan Ha, Chang Dong Yeo, Hyeon Hui Kang, Jin Woo Kim, Sang Haak Lee
Hypoxia is a critical characteristic of solid tumors with respect to cancer cell survival, angiogenesis, and metastasis. Hyperoxic treatment has been attempted to reverse hypoxia by enhancing the amount of dissolved oxygen in the plasma. In this study, we evaluated the effects of normobaric hyperoxia on the progression of lung cancer to determine whether oxygen toxicity can be used in cancer therapy. Following a tail vein injection of the Lewis lung carcinoma cells, C57BL/6J mice were exposed to a 24-h normobaric hyperoxia/normoxia cycle for two weeks...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29754249/trpa1-channels-expression-in-non-neuronal-murine-lung-tissues-and-dispensability-for-hyperoxia-induced-alveolar-epithelial-hyperplasia
#5
Martina Kannler, Robin Lüling, Ali Önder Yildirim, Thomas Gudermann, Dirk Steinritz, Alexander Dietrich
Transient receptor potential A1 (TRPA1) channels were originally characterized in neuronal tissues but also identified in lung epithelium by staining with fluorescently coupled TRPA1 antibodies. Its exact function in non-neuronal tissues, however, is elusive. TRPA1 is activated in vitro by hypoxia and hyperoxia and is therefore a promising TRP candidate for sensing hyperoxia in pulmonary epithelial cells and for inducing alveolar epithelial hyperplasia. Here, we isolated tracheal, bronchial, and alveolar epithelial cells and show low but detectable TRPA1 mRNA levels in all these cells as well as TRPA1 protein by Western blotting in alveolar type II (AT II) cells...
May 12, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29748217/maternally-derived-yolk-antioxidants-buffer-the-developing-avian-embryo-against-oxidative-stress-induced-by-hyperoxia
#6
Hannah Watson, Pablo Salmón, Caroline Isaksson
In oviparous animals, maternally transferred antioxidants protect the embryo from oxidative damage from high rates of reactive oxygen species (ROS) production incurred by rapid growth. Elevated ROS exposure - beyond that incurred by normal growth - can occur as a result of exposure to exogenous factors (e.g. pollutants, toxins, radiation), increasing the risk of oxidative damage, with potentially adverse consequences for embryonic development and long-term fitness. The capacity of the avian embryo's antioxidant protection system to counter an increased exogenous oxidative threat is poorly understood...
May 10, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29747570/ketamine-exacerbates-cortical-neuroapoptosis-under-hyperoxic-conditions-by-upregulating-expression-of-the-n-methyl-d-aspartate-receptor-subunit-nr1-in-the-developing-rat-brain
#7
Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang
BACKGROUND: Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory upregulation of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit. This study investigated the impact of ketamine administration under hyperoxic conditions on cortical neuroapoptosis and NR1 subunit expression in the infant rat brain. METHODS: Male, 7-day-old rats were randomly allocated to four groups: control, ketamine, hyperoxia, and ketamine + hyperoxia (n = 18 per group)...
May 10, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29741761/peptidome-analysis-of-lung-tissues-from-a-hyperoxia-induced-bronchopulmonary-dysplasia-mouse-model-insights-into-the-pathophysiological-process-of-bronchopulmonary-dysplasia
#8
Jing Yin, Xingyun Wang, Le Zhang, Xing Wang, Heng Liu, Yin Hu, Xiangyun Yan, Yongfeng Tang, Juan Wang, Zhengyin Li, Zhangbin Yu, Yan Cao, Shuping Han
The aim of this study was to identify and compare the peptidomic profiles of lung tissues from neonatal mice with and without bronchopulmonary dysplasia (BPD). Hyperoxia was used to establish the BPD mouse model. Lung tissues obtained on postnatal day (PND) 9 were processed for analysis via histological staining and label-free liquid chromatography-mass spectrometry (LC-MS/MS). Histological analysis of the lung sections from the BPD group showed significant alveolar simplification and aberrant pulmonary vascularization...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29724000/oxygen-induced-retinopathy-from-recurrent-intermittent-hypoxia-is-not-dependent-on-resolution-with-room-air-or-oxygen-in-neonatal-rats
#9
Kay D Beharry, Charles L Cai, Jacqueline Skelton, Faisal Siddiqui, Christina D'Agrosa, Johanna Calo, Gloria B Valencia, Jacob V Aranda
Preterm infants often experience intermittent hypoxia (IH) with resolution in room air (RA) or hyperoxia (Hx) between events. Hypoxia is a major inducer of vascular endothelial growth factor, which plays a key role in normal and aberrant retinal angiogenesis. This study tested the hypothesis that neonatal IH which resolved with RA is less injurious to the immature retina than IH resolved by Hx between events. Newborn rats were exposed to: (1) Hx (50% O₂) with brief hypoxia (12% O₂); (2) RA with 12% O₂; (3) Hx with RA; (4) Hx only; or (5) RA only, from P0 to P14...
May 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29721817/the-impact-of-hyperoxia-on-outcomes-after-cardiac-surgery-a-systematic-review-and-narrative-synthesis
#10
Jeffrey Heinrichs, Carly Lodewyks, Christine Neilson, Ahmed Abou-Setta, Hilary P Grocott
PURPOSE: Historically, cardiac surgery patients have often been managed with supraphysiologic intraoperative oxygen levels to protect against the risks of cellular hypoxia inherent in the un-physiologic nature of surgery and cardiopulmonary bypass. This may result in excessive reactive oxygen species generation and exacerbation of ischemia-reperfusion injury. In this review, we synthesize all available data from randomized controlled trials (RCTs) to investigate the impact that hyperoxia has on postoperative organ dysfunction, length of stay, and mortality during adult cardiac surgery...
May 2, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29712880/different-effects-of-normobaric-oxygen-in-normotensive-versus-hypertensive-rats-after-focal-cerebral-ischemia
#11
Jing Lan, Elga Esposito, Cenk Ayata, Aneesh B Singhal, Eng H Lo, Xunming Ji
BACKGROUND AND PURPOSE: The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia. METHODS: Male Sprague-Dawley and spontaneously hypertensive rats were subjected to transient focal ischemia via intraluminal filament occlusions of the middle cerebral artery. NBO was started 15 minutes after ischemic onset and stopped at the time of reperfusion...
April 30, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29708586/oxygen-supplementation-for-critically-ill-patients-a-protocol-for-a-systematic-review
#12
REVIEW
M Barbateskovic, O L Schjørring, J C Jakobsen, C S Meyhoff, B S Rasmussen, A Perner, J Wetterslev
BACKGROUND: In critically ill patients, hypoxaemia is a common clinical manifestation of inadequate gas exchange in the lungs. Supplemental oxygen is therefore given to all critically ill patients. This can result in hyperoxaemia, and some observational studies have identified harms with hyperoxia. The objective of this systematic review is to critically assess the evidence of randomised clinical trials on the effects of higher versus lower inspiratory oxygen fractions or targets of arterial oxygenation in critically ill adult patients...
April 30, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29704562/a-survey-to-identify-the-breach-between-evidence-and-practice-in-the-prevention-of-surgical-infection-time-to-take-action
#13
REVIEW
Josep M Badia, Anna L Casey, Inés Rubio-Pérez, Cynthia Crosby, Nares Arroyo-García, José Balibrea Del Castillo
BACKGROUND: The knowledge of the grade of implementation of preventative measures for surgical site infection (SSI) is crucial prior to planning dissemination strategies. METHODS: Online survey among the members of the Spanish Association of Surgeons (AEC) to know the actual application of measures, and to compare them with new recommendations issued by international organizations. RESULTS: Most of the 835 responding surgeons work in National Health Service Hospitals (91...
April 25, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29703148/deletion-of-soluble-epoxide-hydrolase-attenuates-mice-hyperoxic-acute-lung-injury
#14
Li-Ping Liu, Bin Li, Tian-Kui Shuai, Lei Zhu, Yu-Min Li
BACKGROUND: Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear. METHODS: ALI was induced by exposure to 100% oxygen in an airtight cage for 72 h in wild-type (WT) and sEH gene deletion (EPHX2-/- ) mice. ALI was assessed by the lung dry/wet ratio, alveolar capillary protein leak, and the infiltration of inflammatory cells in the lung. RESULTS: Hyperoxia elevated sEH activity in WT mice...
April 27, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29698744/hyperoxia-induces-epigenetic-changes-in-newborn-mice-lungs
#15
Miroslaw Bik-Multanowski, Cecilie Revhaug, Agnieszka Grabowska, Artur Dobosz, Anna Madetko-Talowska, Magdalena Zasada, Ola Didrik Saugstad
Supplemental oxygen exposure is a risk factor for the development of bronchopulmonary dysplasia (BPD). Reactive oxygen species may damage lung tissue, but hyperoxia also has the potential to alter genome activity via changes in DNA methylation. Understanding the epigenetic potential of hyperoxia would enable further improvement of the therapeutic strategies for BPD. Here we aimed to identify hyperoxia-related alterations in DNA methylation, which could affect the activity of crucial genetic pathways involved in the development of hyperoxic lung injury...
April 23, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29696212/feasibility-of-high-intensity-interval-training-with-hyperoxia-vs-intermittent-hyperoxia-and-hypoxia-in-cancer-patients-undergoing-chemotherapy-study-protocol-of-a-randomized-controlled-trial
#16
Moritz Schumann, Holger Schulz, Anthony C Hackney, Wilhelm Bloch
Exercise has been well demonstrated to potentially reduce chemotherapy-induced side effects and possibly aid slowing down tumor growth in cancer patients but exercise training adherence is typically low. Thus, training regimens which are perceived less strenuous but do not compromise the training-induced beneficial adaptations will help to increase adherence to exercise and reduce attrition. This 4-armed study aims to investigate the effects of high intensity interval training (HIIT) in hyperoxia versus intermittent hyperoxia and hypoxia in cancer patients undergoing chemotherapy...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29692886/what-are-the-optimum-components-in-a-care-bundle-aimed-at-reducing-post-operative-pulmonary-complications-in-high-risk-patients
#17
Sophie V Griffiths, Daniel H Conway, Michael Sander, Ib Jammer, Michael P W Grocott, Ben C Creagh-Brown
Background: Post-operative pulmonary complications (POPC) are common, predictable and associated with increased morbidity and mortality, independent of pre-operative risk. Interventions to reduce the incidence of POPC have been studied individually, but the use of a care bundle has not been widely investigated. The purpose of our work was to use Delphi consensus methodology and an independently chosen expert panel to formulate a care bundle for patients identified as being at high of POPC, as preparation towards an evaluation of its effectiveness at reducing POPC...
2018: Perioperative Medicine
https://www.readbyqxmd.com/read/29691310/oxygen-drives-skeletal-muscle-remodeling-in-an-amphibious-fish-out-of-water
#18
Giulia S Rossi, Andy J Turko, Patricia A Wright
Skeletal muscle remodeling in response to terrestrial acclimation improves the locomotor performance of some amphibious fishes on land, but the cue for this remodeling is unknown. We tested the hypothesis that muscle remodeling in the amphibious Kryptolebias marmoratus on land is driven by higher O2 availability in atmospheric air, and the alternative hypothesis that remodeling is induced by a different environmental or physiological condition fish experience on land. Fish were acclimated to 28 days of air, aquatic hyperoxia, hypercapnia, hypoxia, elevated temperature, or fasting conditions...
April 24, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29683756/de-novo-expression-of-transfected-sirtuin-3-enhances-susceptibility-of-human-mcf-7-breast-cancer-cells-to-hyperoxia-treatment
#19
Marija Pinterić, Iva I Podgorski, Sandra Sobočanec, Marijana Popović Hadžija, Mladen Paradžik, Ana Dekanić, Maja Marinović, Mirna Halasz, Robert Belužić, Grazia Davidović, Andreja Ambriović Ristov, Tihomir Balog
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age-related pathologies. Hyperoxic treatment (i.e. generator of ROS) was shown to support some tumourigenic properties, but finally suppresses growth of certain mammary carcinoma cells...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29682448/cortical-hypoperfusion-and-reduced-cerebral-metabolic-rate-of-oxygen-in-the-arca%C3%AE-mouse-model-of-alzheimer-s-disease
#20
Ruiqing Ni, Markus Rudin, Jan Klohs
The effect of cerebral amyloidosis on cerebral hemodynamics was investigated with photoacoustic tomography (PAT) and magnetic resonance imaging (MRI). First, the sensitivity and robustness of PAT for deriving metrics of vascular and tissue oxygenation in the murine brain was assessed in wild-type mice with a hyperoxia-normoxia challenge. Secondly, cerebral oxygenation was assessed in young and aged arcAβ mice and wild-type controls with PAT, while cerebral blood flow (CBF) was determined by perfusion MRI. The investigations revealed that PAT can sensitively and robustly detect physiological changes in vascular and tissue oxygenation...
June 2018: Photoacoustics
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