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Hyperoxia

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https://www.readbyqxmd.com/read/27913427/intermittent-hypoxia-during-recovery-from-neonatal-hyperoxic-lung-injury-causes-long-term-impairment-of-alveolar-development-a-new-rat-model-of-bpd
#1
Anastasiya Mankouski, Crystal Kantores, Mathew J Wong, Julijana Ivanovska, Amish Jain, Eric J Benner, Stanley N Mason, A Keith Tanswell, Richard L Auten, Robert P Jankov
Bronchopulmonary dysplasia (BPD) is a chronic lung injury characterized by impaired alveologenesis that may persist into adulthood. Rat models of BPD using varying degrees of hyperoxia to produce injury either cause early mortality or spontaneously recover following removal of the inciting stimulus, thus limiting clinical relevance. We sought to refine an established rat model induced by exposure to 60% O2 from birth by following hyperoxia with intermittent hypoxia (IH). Rats exposed from birth to air or 60% O2 until day 14 were recovered in air with or without IH (FiO2 = 0...
December 2, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27907119/gray-matter-hypoxia-in-the-brain-of-the-experimental-autoimmune-encephalomyelitis-model-of-multiple-sclerosis
#2
Thomas W Johnson, Ying Wu, Nabeela Nathoo, James A Rogers, V Wee Yong, Jeff F Dunn
BACKGROUND: Multiple sclerosis (MS) has a significant inflammatory component and may have significant gray matter (GM) pathophysiology. Brain oxygenation is a sensitive measurement of the balance between metabolic need and oxygen delivery. There is evidence that inflammation and hypoxia are interdependent. In this paper, we applied novel, implanted PO2 sensors to measure hypoxia in cortical and cerebellar GM, in an inflammation-induced mouse model of MS. OBJECTIVE: Quantify oxygenation in cortical and cerebellar GM in the awake, unrestrained experimental autoimmune encephalomyelitis (EAE) mouse model and to relate the results to symptom level and disease time-course...
2016: PloS One
https://www.readbyqxmd.com/read/27903670/oxygen-the-lung-and-the-diver-friends-and-foes
#3
Pieter-Jan A M van Ooij, Peter J Sterk, Robert A van Hulst
Worldwide, the number of professional and sports divers is increasing. Most of them breathe diving gases with a raised partial pressure of oxygen (PO2 ). However, if the PO2 is between 50 and 300 kPa (375-2250 mmHg) (hyperoxia), pathological pulmonary changes can develop, known as pulmonary oxygen toxicity (POT). Although in its acute phase, POT is reversible, it can ultimately lead to non-reversible pathological changes. Therefore, it is important to monitor these divers to prevent them from sustaining irreversible lesions...
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27867482/normobaric-oxygen-treatment-in-acute-ischemic-stroke-a-clinical-perspective
#4
REVIEW
Shu-Hai Shi, Zhi-Feng Qi, Yu-Min Luo, Xun-Ming Ji, Ke Jian Liu
Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27867481/temporal-variation-in-the-response-of-tumors-to-hyperoxia-with-breathing-carbogen-and-oxygen
#5
Hua-Gang Hou, Nadeem Khan, Gai-Xin Du, Sassan Hodge, Harold M Swartz
The effect of hyperoxygenation with carbogen (95% O2 + 5% CO2) and 100% oxygen inhalation on partial pressure of oxygen (pO2) of radiation-induced fibrosarcoma (RIF-1) tumor was investigated. RIF-1 tumors were innoculated in C3H mice, and aggregates of oximetry probe, lithium phthalocyanine (LiPc), was implanted in each tumor. A baseline tumor pO2 was measured by electron paramagnetic resonance (EPR) oximetry for 20 minutes in anesthetized mice breathing 30% O2 and then the gas was switched to carbogen or 100 % oxygen for 60 minutes...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27861592/hyperoxia-induced-proliferative-retinopathy-early-interruption-of-retinal-vascular-development-with-severe-and-irreversible-neurovascular-disruption
#6
Michelle Lajko, Herminio J Cardona, Joann M Taylor, Ronil S Shah, Kathryn N Farrow, Amani A Fawzi
Bronchopulmonary dysplasia (BPD) is a major cause of neonatal morbidity in premature infants, occurring as a result of arrested lung development combined with multiple postnatal insults. Infants with BPD exposed to supplemental oxygen are at risk of retinopathy of prematurity as well. Thus, we studied the effects of hyperoxia on the retinal vasculature in a murine model of BPD. The retinal phenotype of this model, which we termed hyperoxia-induced proliferative retinopathy (HIPR), shows severe disruption of retinal vasculature and loss of vascular patterning, disorganized intra-retinal angiogenesis, inflammation and retinal detachment...
2016: PloS One
https://www.readbyqxmd.com/read/27850642/1004-the-effect-of-blocking-epha2-ephrina1-pathway-in-hyperoxia-induced-lung-injury
#7
Kyung Soo Chung, Chi Young Kim, Ju Hye Shin, Moo Suk Park, Se Kyu Kim, Joon Chang, Youngsam Kim
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850575/937-prevalence-and-outcomes-of-hyperoxia-in-the-intensive-care-unit
#8
Shahzad Shaefi, Ariel Mueller, Valerie Banner-Goodspeed, Sajid Shahul, Todd Sarge, Jonathan Sevransky, Daniel Talmor
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837190/hyperoxia-results-in-increased-aerobic-metabolism-following-acute-brain-injury
#9
Arnab Ghosh, David Highton, Christina Kolyva, Ilias Tachtsidis, Clare E Elwell, Martin Smith
Acute brain injury is associated with depressed aerobic metabolism. Below a critical mitochondrial pO2 cytochrome c oxidase, the terminal electron acceptor in the mitochondrial respiratory chain, fails to sustain oxidative phosphorylation. After acute brain injury, this ischaemic threshold might be shifted into apparently normal levels of tissue oxygenation. We investigated the oxygen dependency of aerobic metabolism in 16 acutely brain-injured patients using a 120-min normobaric hyperoxia challenge in the acute phase (24-72 h) post-injury and multimodal neuromonitoring, including transcranial Doppler ultrasound-measured cerebral blood flow velocity, cerebral microdialysis-derived lactate-pyruvate ratio (LPR), brain tissue pO2 (pbrO2), and tissue oxygenation index and cytochrome c oxidase oxidation state (oxCCO) measured using broadband spectroscopy...
November 11, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27835780/brain-adaptation-to-hypoxia-and-hyperoxia-in-mice
#10
Laura Terraneo, Rita Paroni, Paola Bianciardi, Toniella Giallongo, Stephana Carelli, Alfredo Gorio, Michele Samaja
AIMS: Hyperoxic breathing might lead to redox imbalance and signaling changes that affect cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative stress. Our aim is to dissect the cerebral tissue responses to altered O2 fractions in breathed air by assessing the redox imbalance and the recruitment of the hypoxia signaling pathways. RESULTS: Mice were exposed to mild hypoxia (10%O2), normoxia (21%O2) or mild hyperoxia (30%O2) for 28 days, sacrificed and brain tissue excised and analyzed...
November 4, 2016: Redox Biology
https://www.readbyqxmd.com/read/27834669/a-translational-cellular-model-to-study-the-impact-of-high-frequency-oscillatory-ventilation-hfov-on-human-epithelial-cell-function
#11
Anja Karolin Mowes, Beatriz E de Jongh, Timothy Cox, Yan Zhu, Thomas H Shaffer
High frequency oscillatory ventilation (HFOV) has been proposed as gentle ventilation strategy to prevent lung injury in the preterm infant. High frequency ventilation leads to dimensional and mechanical airway deformation in animal airway models, which is consistent with translational studies demonstrating the impact of oxygen and biophysical stresses on normal airway cellular function. There is an overall paucity of clinical and cellular data on the impact of HFOV on the conducting airway. We developed an innovative method to test the impact of the clinical HFO Ventilator (Sensormedic 3100A) on human epithelial cell function...
November 10, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27832407/central-venous-to-arterial-carbon-dioxide-difference-and-the-effect-of-venous-hyperoxia-a-limiting-factor-or-an-additional-marker-of-severity-in-shock
#12
P Saludes, L Proença, G Gruartmoner, L Enseñat, A Pérez-Madrigal, C Espinal, J Mesquida
Central venous-to-arterial carbon dioxide difference (PcvaCO2) has demonstrated its prognostic value in critically ill patients suffering from shock, and current expert recommendations advocate for further resuscitation interventions when PcvaCO2 is elevated. PcvaCO2 combination with arterial-venous oxygen content difference (PcvaCO2/CavO2) seems to enhance its performance when assessing anaerobic metabolism. However, the fact that PCO2 values might be altered by changes in blood O2 content (the Haldane effect), has been presented as a limitation of PCO2-derived variables...
November 10, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27826421/cocktail-treatment-a-promising-strategy-to-treat-acute-cerebral-ischemic-stroke
#13
REVIEW
Li-Jun Liang, Jin-Ming Yang, Xin-Chun Jin
Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protective agents targeting ischemia and reperfusion respectively may obtain substantially better results than a single agent. Normobaric hyperoxia (NBO) has been shown to exhibit neuro- and vaso-protective effects by improving tissue oxygenation when it is given during ischemia, however the effect of NBO would diminish when the duration of ischemia and reperfusion was extended...
March 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27810458/effect-of-hyperoxia-on-cerebral-blood-flow-velocity-and-regional-oxygen-saturation-in-patients-operated-upon-for-severe-traumatic-brain-injury-the-influence-of-cerebral-blood-flow-autoregulation
#14
Sarasa Sahoo, Veena Sheshadri, Kamath Sriganesh, K R Madhsudana Reddy, M Radhakrishnan, G S Umamaheswara Rao
BACKGROUND: The effect of normobaric hyperoxia on brain oxygenation in the presence or absence of intact autoregulation has not been studied till now in acute traumatic brain injury (TBI). METHODS: In this prospective clinical investigation in fifty patients operated for severe TBI, cerebral blood flow (CBF) velocity in the middle cerebral artery (MCA) was measured using transcranial doppler (TCD). Regional cerebral oxygen saturation (rSO2) using near infra-red spectroscopy (NIRS) at three different inspired oxygen fractions (FiO2 of 0...
October 31, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27792858/exposure-to-high-concentration-oxygen-in-the-neonatal-period-induces-abnormal-retinal-vascular-patterning-in-mice
#15
Akane Morita, Hiroko Ushikubo, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara
The interruption of vascular development could cause structural and functional abnormalities in tissues. We have previously reported that short-term treatment of newborn mice with vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors induces abnormal retinal vascular growth and patterns. An exposure of neonatal mice to high-concentration oxygen disturbs normal retinal vascular development. The present study aimed to determine (1) whether vascular abnormalities are observed in the retina of newborn mice exposed to high concentrations of oxygen, and (2) how astrocyte network formation is affected following the exposure to hyperoxia...
October 28, 2016: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://www.readbyqxmd.com/read/27783043/progressive-vascular-functional-and-structural-damage-in-a-bronchopulmonary-dysplasia-model-in-preterm-rabbits-exposed-to-hyperoxia
#16
Julio Jiménez, Jute Richter, Taro Nagatomo, Thomas Salaets, Rozenn Quarck, Allard Wagennar, Hongmei Wang, Jeroen Vanoirbeek, Jan Deprest, Jaan Toelen
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a lung development that mimics humans and can be used as a translational model to test novel treatment options. In preterm rabbits, exposure to hyperoxia leads to parenchymal changes, yet vascular damage has not been studied in this model. In this study we document the early functional and structural changes of the lung vasculature in preterm rabbits that are induced by hyperoxia after birth...
October 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27777452/uv-c-and-hyperoxia-abiotic-stresses-to-improve-healthiness-of-carrots-study-of-combined-effects
#17
Anna Carolina Formica-Oliveira, Ginés Benito Martínez-Hernández, Encarna Aguayo, Perla A Gómez, Francisco Artés, Francisco Artés-Hernández
Phenolic compounds are phytochemicals with high health-promoting properties. Carrot is a vegetable highly worldwide consumed although its phenolic content is low compared to other plant products. The aim of this work was to evaluate changes in phenolic compounds in carrots caused by abiotic stresses. The phenylalanine ammonia-lyase (PAL) activity, phenolic compounds and total antioxidant capacity (TAC) changes during storage up to 72 h at 15 °C after wounding (shredding), 9 kJ UV-C m(-2) pretreatment and hyperoxia (80 kPa) conditions of carrots were studied...
September 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27770432/fgf10-deficiency-is-causative-for-lethality-in-a-mouse-model-of-bronchopulmonary-dysplasia
#18
Cho-Ming Chao, Faady Yahya, Alena Moiseenko, Caterina Tiozzo, Amit Shrestha, Negah Ahmadvand, Elie El Agha, Jennifer Quantius, Salma Dilai, Vahid Kheirollahi, Matthew Jones, Jochen Wilhem, Gianni Carraro, Harald Ehrhardt, Klaus-Peter Zimmer, Guillermo Barreto, Katrin Ahlbrecht, Rory E Morty, Susanne Herold, Rosanna G Abellar, Werner Seeger, Ralph Schermuly, Jin-San Zhang, Parviz Minoo, Saverio Bellusci
Inflammation-induced FGF10 protein deficiency is associated with bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurely born infants characterized by arrested alveolar development. So far, experimental evidence for a direct role of FGF10 in lung disease is lacking. Using the hyperoxia-induced neonatal lung injury as a mouse model of BPD, the impact of Fgf10 deficiency in Fgf10(+/-) versus Fgf10(+/+) pups was investigated. In normoxia, no lethality of Fgf10(+/+) or Fgf10(+/-) pups was observed...
October 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27769245/n-methyl-d-aspartate-receptor-activation-mediates-lung-fibroblast-proliferation-and-differentiation-in-hyperoxia-induced-chronic-lung-disease-in-newborn-rats
#19
YanRui Wang, ShaoJie Yue, ZiQiang Luo, ChuanDing Cao, XiaoHe Yu, ZhengChang Liao, MingJie Wang
BACKGROUND: Previous studies have suggested that endogenous glutamate and its N-methyl-D-aspartate receptors (NMDARs) play important roles in hyperoxia-induced acute lung injury in newborn rats. We hypothesized that NMDAR activation also participates in the development of chronic lung injury after withdrawal of hyperoxic conditions. METHODS: In order to rule out the anti-inflammatory effects of NMDAR inhibitor on acute lung injury, the efficacy of MK-801 was evaluated in vivo using newborn Sprague-Dawley rats treated starting 4 days after cessation of hyperoxia exposure (on postnatal day 8)...
October 21, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27765063/responses-to-altered-oxygen-tension-are-distinct-between-human-stem-cells-of-high-and-low-chondrogenic-capacity
#20
Devon E Anderson, Brandon D Markway, Derek Bond, Helen E McCarthy, Brian Johnstone
BACKGROUND: Lowering oxygen from atmospheric level (hyperoxia) to the physiological level (physioxia) of articular cartilage promotes mesenchymal stem cell (MSC) chondrogenesis. However, the literature is equivocal regarding the benefits of physioxic culture on preventing hypertrophy of MSC-derived chondrocytes. Articular cartilage progenitors (ACPs) undergo chondrogenic differentiation with reduced hypertrophy marker expression in hyperoxia but have not been studied in physioxia. This study sought to delineate the effects of physioxic culture on both cell types undergoing chondrogenesis...
October 20, 2016: Stem Cell Research & Therapy
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