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https://www.readbyqxmd.com/read/29349952/estimation-of-cerebral-metabolic-rate-of-oxygen-consumption-using-combined-multiwavelength-photoacoustic-microscopy-and-doppler-microultrasound
#1
Yan Jiang, Roger Zemp
The metabolic rate of oxygen consumption is an important metric of tissue oxygen metabolism and is especially critical in the brain, yet few methods are available for measuring it. We use a custom combined photoacoustic-microultrasound system and demonstrate cerebral oxygen consumption estimation in vivo. In particular, the cerebral metabolic rate of oxygen consumption was estimated in a murine model during variation of inhaled oxygen from hypoxia to hyperoxia. The hypothesis of brain autoregulation was confirmed with our method even though oxygen saturation and flow in vessels changed...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29349730/ccn5-in-alveolar-epithelial-proliferation-and-differentiation-during-neonatal-lung-oxygen-injury
#2
Najla Fiaturi, Joshua W Russo, Heber C Nielsen, John J Castellot
Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epithelial cells in the lung. RDS treatment includes oxygen and respiratory support that improve survival but also increase the risk for bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by arrested alveolarization, airway hyperreactivity, and pulmonary hypertension...
January 18, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29347982/emergency-department-hyperoxia-is-associated-with-increased-mortality-in-mechanically-ventilated-patients-a-cohort-study
#3
David Page, Enyo Ablordeppey, Brian T Wessman, Nicholas M Mohr, Stephen Trzeciak, Marin H Kollef, Brian W Roberts, Brian M Fuller
BACKGROUND: Providing supplemental oxygen is fundamental in the management of mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes associated with hyperoxia. However, these previous data in the critically ill have not focused on outcomes associated with brief hyperoxia exposure immediately after endotracheal intubation. Therefore, the objectives of this study were to evaluate the impact of isolated early hyperoxia exposure in the emergency department (ED) on clinical outcomes among mechanically ventilated patients with subsequent normoxia in the intensive care unit (ICU)...
January 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29345197/neonatal-hyperoxia-depletes-pulmonary-vein-cardiomyocytes-in-adult-mice-via-mitochondrial-oxidation
#4
Min Yee, Ethan David Cohen, William Domm, George A Porter, Andrew N McDavid, Michael A O'Reilly
Supplemental oxygen given to preterm infants has been associated with permanently altering postnatal lung development. Now that these individuals are reaching adulthood, there is growing concern that early-life oxygen exposure may also promote cardiovascular disease through poorly understood mechanisms. We previously reported that adult mice exposed to 100% oxygen between postnatal days 0-4 develop pulmonary hypertension defined pathologically by capillary rarefaction, dilation of arterioles and veins, cardiac failure, and a reduced lifespan...
January 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29340836/primary-culture-of-lung-fibroblasts-from-hyperoxia-exposed-rats-and-a-proliferative-characteristics-study
#5
Shi-Meng Zhao, Hong-Min Wu, Mei-Ling Cao, Dan Han
Lung fibrosis is an ultimate consequence of bronchopulmonary dysplasia (BPD) which shows the excessive proliferation of lung fibroblasts (LFs). To find a better model for studying the role of LFs in hyperoxia-induced lung fibrosis at the cellular level, we isolated LFs from the lung tissue of hyperoxia- and normoxia-exposed rat lungs on postnatal days 7, 14 and 21 for primary culture to study their proliferative behavior. In the present study, the LF predominance was > 95% in our culture method. The LFs isolated from rats exposed to hyperoxia in vivo showed significantly greater proliferation than that from normoxia-exposed rats...
January 16, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29334496/oxygen-in-the-critically-ill-friend-or-foe
#6
Elisa Damiani, Abele Donati, Massimo Girardis
PURPOSE OF REVIEW: To examine the potential harmful effects of hyperoxia and summarize the results of most recent clinical studies evaluating oxygen therapy in critically ill patients. RECENT FINDINGS: Excessive oxygen supplementation may have detrimental pulmonary and systemic effects because of enhanced oxidative stress and inflammation. Hyperoxia-induced lung injury includes altered surfactant protein composition, reduced mucociliary clearance and histological damage, resulting in atelectasis, reduced lung compliance and increased risk of infections...
January 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29325709/acute-hyperoxia-induces-systemic-responses-with-no-major-changes-in-peripheral-tissues-in-the-senegalese-sole-solea-senegalensis-kaup-1858
#7
Marina Machado, Diogo Malheiro, Ana Couto, Jonathan M Wilson, Matthew Guerreiro, Rita Azeredo, Jon C Svendsen, António Afonso, Renata Serradeiro, Benjamín Costas
Senegalese sole Solea senegalensis is currently farmed in recirculation aquaculture systems that often involve water re-oxygenation, which in turn may cause acute or prolonged hyperoxia exposures. In order to understand the impact of acute hyperoxia on the fish immune system and peripheral tissues such as gills and gut, Senegalese sole juveniles (30.05 ± 1.72 g) were exposed to normoxia (100% O2sat) as control and two hyperoxic conditions (150 and 200% O2sat) and sampled at 4 and 24 h. Fish haematological profile, total and differential blood cell counts and plasma immune parameters were analysed...
January 8, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29319634/hyperoxia-and-hypocapnia-during-pediatric-extracorporeal-membrane-oxygenation-associations-with-complications-mortality-and-functional-status-among-survivors
#8
Katherine Cashen, Ron Reeder, Heidi J Dalton, Robert A Berg, Thomas P Shanley, Christopher J L Newth, Murray M Pollack, David Wessel, Joseph Carcillo, Rick Harrison, J Michael Dean, Robert Tamburro, Kathleen L Meert
OBJECTIVES: To determine the frequency of hyperoxia and hypocapnia during pediatric extracorporeal membrane oxygenation and their relationships to complications, mortality, and functional status among survivors. DESIGN: Secondary analysis of data collected prospectively by the Collaborative Pediatric Critical Care Research Network. SETTING: Eight Collaborative Pediatric Critical Care Research Network-affiliated hospitals. PATIENTS: Age less than 19 years and treated with extracorporeal membrane oxygenation...
January 9, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29316302/oxygen-supply-did-not-affect-how-lizards-responded-to-thermal-stress
#9
Agustin Camacho Guerrero, John M VandenBrooks, Angela Riley, Rory S Telemeco, Michael J Angilletta
Zoologists rely on mechanistic niche models of behavioral thermoregulation to understand how animals respond to climate change. These models predict that species will need to disperse to higher altitudes to persist in a warmer world. However, thermal stress and thus thermoregulatory behavior may depend on atmospheric oxygen as well as environmental temperatures. Severe hypoxia causes animals to prefer lower body temperatures, which could be interpreted as evidence that oxygen supply limits heat tolerance. Such a constraint could prevent animals from successfully dispersing to high elevations during climate change...
January 9, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29315540/stereological-analysis-of-individual-lung-lobes-during-normal-and-aberrant-mouse-lung-alveolarisation
#10
Tuong-Van Hoang, Claudio Nardiello, David E Surate Solaligue, José Alberto Rodríguez-Castillo, Philipp Rath, Konstantin Mayer, István Vadász, Susanne Herold, Kathrin Ahlbrecht, Werner Seeger, Rory E Morty
The quantitative assessment of the lung architecture forms the foundation of many studies on lung development and lung diseases, where parameters such as alveoli number, alveolar size, and septal thickness are quantitatively influenced by developmental or pathological processes. Given the pressing need for robust data that describe the lung structure, there is currently much enthusiasm for the development and refinement of methodological approaches for the unbiased assessment of lung structure with improved precision...
January 9, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29308266/ecological-and-evolutionary-significance-of-a-lack-of-capacity-for-extended-developmental-arrest-in-crocodilian-eggs
#11
Sean A Williamson, Roger G Evans, S Charlie Manolis, Grahame J Webb, Richard D Reina
Hypoxia within the oviducts maintains embryonic arrest in turtles at the pre-ovipositional stage, which expands the timeframe over which nesting can occur without compromising embryo survival. The arrest can be extended post-oviposition through incubation of eggs in hypoxia. We determined whether crocodilian embryos have this same capacity. We also tested whether increased oxygen availability during incubation alters hatching success. We incubated freshly laid saltwater crocodile (Crocodylus porosus) eggs (N = 83) at 32°C in one of five treatments; control (normoxia; 21% O2), 3-day and 6-day hypoxia (1% O2), or 3-day and 6-day hyperoxia (42% O2)...
December 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29299669/air-breathing-behavior-oxygen-concentrations-and-ros-defense-in-the-swimbladders-of-two-erythrinid-fish-the-facultative-air-breathing-jeju-and-the-non-air-breathing-traira-during-normoxia-hypoxia-and-hyperoxia
#12
Bernd Pelster, Chris M Wood, Ellen Jung, Adalberto L Val
The jeju Hoplerythrinus unitaeniatus and the traira Hoplias malabaricus are two neighboring genera from the family of erythrinid fish, both possessing a two-chambered physostomous swimbladder. In the jeju the anterior section of the posterior bladder is highly vascularized, and the swimbladder is used for aerial respiration; the traira, in turn, is a water-breather that uses the swimbladder as a buoyancy organ and not for aerial oxygen uptake. Measurement of swimbladder oxygen partial pressure (PO2) of fish kept at 26 °C in normoxic, hyperoxic (28-32 mg O2 L- 1) or hypoxic (1-1...
January 3, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29296004/automated-versus-manual-control-of-inspired-oxygen-to-target-oxygen-saturation-in-preterm-infants-a-systematic-review-and-meta-analysis
#13
Souvik Mitra, Balpreet Singh, Walid El-Naggar, Douglas D McMillan
OBJECTIVES: To conduct a systematic review of clinical trials comparing automated versus manual fraction of inspired oxygen (FiO2) control to target oxygen saturation (SpO2) in preterm infants. DESIGN: The authors searched MEDLINE, Embase, CENTRAL, and CINAHL from inception upto December 2016, reviewed conference proceedings and sought results of unpublished trials. Studies were included if automated FiO2 control was compared to manual control in preterm infants on positive pressure respiratory support...
January 2, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29285182/effects-of-caszi-on-bronchopulmonary-development-of-neonatal-rats
#14
Liping Xu, Ruifang Tong, Xiangnan Li, Lihong Liang, Han Huang
The effect of CASZI on bronchopulmonary development in neonatal rats was investigated. Forty SD rats were randomly divided into the control group (n=20) and the experimental group (n=20) using a random number table. The experimental group was treated with hyperoxia to establish the bronchopulmonary dysplasia (BPD) model, while the control group received no treatment. At 14 days of experiment, rats in each group were treated, and lung tissues were taken for hematoxylin and eosin (H&E) staining. Radial alveolar count (RAC) and morphological changes in lung tissues were observed under a microscope, and the thickness of respiratory membrane was detected via IPP6 image...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29281864/long-term-effects-of-neonatal-hyperoxia-in-adult-mice
#15
Vasantha Hs Kumar, Huamei Wang, Sergei Kishkurno, Babu S Paturi, Lori Nielsen, Rita M Ryan
BACKGROUND: The outcomes of premature infants have improved greatly, however the health risks in adulthood are still relatively unclear. Bronchopulmonary dysplasia (BPD) in premature infants is a major risk factor producing alteration in lung function and predisposition to later respiratory morbidity, and is associated with hyperoxia. This study explores the effect of neonatal hyperoxia on organ systems in adult mice. METHODS: Newborn mouse litters were randomized to 85%O2 or room air (RA) on P3 for 12 days; mice were sacrificed at P3, P7, P15, 3 months and 9 months...
December 27, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29281189/influence-of-hyperoxia-on-diastolic-myocardial-and-arterial-endothelial-function
#16
T Wunderlich, N Frey, W Kähler, M Lutz, P Radermacher, S Klapa, I Koch, F Tillmans, J Witte, A Koch
OBJECTIVE: Hyperoxia is known to influence cardiovascular and endothelial function, but it is unknown if there are differences between younger and older persons. The aim of this study was to monitor changes in myocardial diastolic function and flow-mediated dilatation (FMD) in younger and elderly volunteers, before and after exposure to relevant hyperbaric hyperoxia. METHODS: 51 male patients were separated into two groups for this study. Volunteers in Group 1 (n=28, mean age 26 ±6, "juniors") and Group 2 (n=23, mean age 53 ±9, "seniors") received standard HBO₂ protocol (240kPa oxygen)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29261569/the-cumulative-partial-pressure-of-arterial-oxygen-is-associated-with-neurological-outcomes-after-cardiac-arrest-treated-with-targeted-temperature-management
#17
Chun Song Youn, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Kyung Woon Jeung, Seung Pill Choi
OBJECTIVE: Hyperoxia could lead to a worse outcome after cardiac arrest. The aim of this study was to investigate the relationship between the cumulative partial pressure of arterial oxygen (PaO2) and neurological outcomes after cardiac arrest treated with targeted temperature management. DESIGN: Retrospective analysis of a prospective cohort. SETTING: An academic tertiary care hospital. PATIENTS: A total of 187 consecutive patients treated with targeted temperature management after cardiac arrest...
December 19, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29250178/toll-like-receptor-9-in-hypoxic-nasopharyngeal-carcinoma-cells-and-its-correlation-with-cell-proliferation-and-apoptosis
#18
Feng Zhang, Deli Wang, Fasheng Chen
The purpose of this study was to investigate the correlation between the expression of Toll-like receptor-9 (TLR-9) and cell proliferation and apoptosis in hypoxic nasopharyngeal carcinoma cells. Human nasopharyngeal carcinoma cell line HNE-1 (EBV positive) and CNE-1 (EBV negative) were used. Cells were divided into normal control group, hypoxia group and hyperoxia group. Hypoxic conditions were 5% CO2 and 0.01% partial pressure of oxygen, hyperoxia conditions were 5% CO2 and 10% partial pressure of oxygen...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29246840/hypoxic-challenge-of-hyperoxic-pulmonary-artery-myocytes-increases-oxidative-stress-due-to-impaired-mitochondrial-superoxide-dismutase-activity
#19
Iram Musharaf, Martha Hinton, Man Yi, Shyamala Dakshinamurti
Infants with lung disease may be exposed to high O2 concentrations, and may have transient hypoxic episodes due to worsening lung pathophysiology, aggravating pulmonary arterial (PA) oxidative stress. NADPH oxidase (NOX) converts O2 to superoxide. Mitochondrial antioxidants such as superoxide dismutase (SOD) are sensitive to O2 tension. We previously reported decreased SOD2 activity in hypoxic PA myocytes due to nitration. In this study, we examined whether a transient hypoxic episode exposes antioxidant defense defects in hyperoxic PA myocytes...
December 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29242645/retinal-angiogenesis-regulates-astrocytic-differentiation-in-neonatal-mouse-retinas-by-oxygen-dependent-mechanisms
#20
Li-Juan Duan, Sarah J Pan, Thomas N Sato, Guo-Hua Fong
In mice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery. The retinal vasculature grows towards the periphery ahead of differentiated astrocytes, but behind astrocytic progenitor cells (APCs) and immature astrocytes. Endothelial cell specific Vegfr-2 disruption in newborn mice not only blocked retinal vascular development but also suppressed astrocytic differentiation, reducing the abundance of differentiated astrocytes while causing the accumulation of precursors...
December 14, 2017: Scientific Reports
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