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https://www.readbyqxmd.com/read/28927826/developmental-plasticity-and-stability-in-the-tracheal-networks-supplying-drosophila-flight-muscle-in-response-to-rearing-oxygen-level
#1
Jon F Harrison, James S Waters, Taylor A Biddulph, Aleksandra Kovacevic, C Jaco Klok, John J Socha
While it is clear that the insect tracheal system can respond in a compensatory manner to both hypoxia and hyperoxia, there is substantial variation in how different parts of the system respond. However, the response of tracheal structures, from the tracheoles to the largest tracheal trunks, have not been studied within one species. In this study, we examined the effect of larval/pupal rearing in hypoxia, normoxia, and hyperoxia (10, 21 or 40 kPa oxygen) on body size and the tracheal supply to the flight muscles of Drosophila melanogaster, using synchrotron radiation micro-computed tomography (SR-µCT) to assess flight muscle volumes and the major tracheal trunks, and confocal microscopy to assess the tracheoles...
September 16, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28923362/human-retinal-endothelial-cells-and-astrocytes-cultured-on-3-d-scaffolds-for-ocular-drug-discovery-and-development
#2
Kay D Beharry, Charles L Cai, Gloria B Valencia, Douglas Lazzaro, Arwin M Valencia, Fabrizio Salomone, Jacob V Aranda
Topical ocular ketorolac improves the outcomes of severe retinopathy of prematurity and when administered with systemic caffeine, decreases the severity of oxygen-induced retinopathy. We tested the hypothesis that co-cultures of human retinal endothelial cells (HRECs) and human retinal astrocytes (HRAs) on 3-dimensional (3-D) hydrogel scaffolds is a more representative biomimetic paradigm of the blood-retinal-barrier (BRB) than 2-D cultures, and should be utilized for preclinical drug discovery and development...
September 15, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28920101/potential-therapeutic-targets-in-nrf2-dependent-protection-against-neonatal-respiratory-distress-disease-predicted-by-cdna-microarray-analysis-and-bioinformatics-tools
#3
Hye-Youn Cho, Xuting Wang, Jianying Li, Douglas A Bell, Steven R Kleeberger
Hyperoxia exposure of newborn rodents has served as a model for bronchopulmonary dysplasia (BPD) phenotypes found in a sub-population of human premature infants. We previously demonstrated that Nrf2 modulates molecular events during saccular-to-alveolar lung maturation and also has a protective role in the pathogenesis of hyperoxia-induced acute lung injury, mortality, arrest of saccular-to-alveolar transition, and lung injury, using Nrf2-deficient and wild-type neonate mice. In this review, we describe how whole-genome transcriptome analyses can identify the means through which Nrf2 transcriptionally modulates organ injury and morphology, cellular growth/proliferation, vasculature development, and immune response during BPD-like pathogenesis...
December 2016: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/28919465/uridine-treatment-protects-against-neonatal-brain-damage-and-long-term-cognitive-deficits-caused-by-hyperoxia
#4
Bulent Goren, Aysen Cakir, Cansu Sevinc, Sema Serter Kocoglu, Busra Ocalan, Ceren Oy, Zehra Minbay, Nevzat Kahveci, Tulin Alkan, Mehmet Cansev
Exposure to excessive oxygen in survivors of preterm birth is one of the factors that underlie the adverse neurological outcome in later life. Various pathological changes including enhanced apoptotic activity, oxidative stress and inflammation as well as decreased neuronal survival has been demonstrated in animal models of neonatal hyperoxia. The aim of the present study was to investigate the effect of administering uridine, an anti-apoptotic agent, on cellular, molecular and behavioral consequences of hyperoxia-induced brain damage in a neonatal rat model...
September 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28915216/protection-by-inhaled-hydrogen-therapy-in-a-rat-model-of-acute-lung-injury-can-be-tracked-in-vivo-using-molecular-imaging
#5
Said H Audi, Elizabeth R Jacobs, Xiao Zhang, Amadou K S Camara, Ming Zhao, Meetha M Medhora, Benjamin Rizzo, Anne V Clough
Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was to evaluate the ability of Tc-hexamethylpropyleneamineoxime (HMPAO) and Tc-duramycin to track the effectiveness of H2 therapy in vivo in the hyperoxia rat model of ALI. Rats were exposed to room air (normoxia), 98% O2 + 2% N2 (hyperoxia) or 98% O2 + 2% H2 (hyperoxia+H2) for up to 60 h...
October 2017: Shock
https://www.readbyqxmd.com/read/28915182/hyperoxia-in-septic-shock-crafty-therapeutic-weapon-or-double-edged-sword
#6
Pierre Asfar, Frédérique Schortgen, Markus Huber-Lang, Peter Radermacher
No abstract text is available yet for this article.
October 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28913711/emergency-neurological-life-support-resuscitation-following-cardiac-arrest
#7
Jonathan Elmer, Kees H Polderman
Cardiac arrest is the most common cause of death in North America. An organized bundle of neurocritical care interventions can improve chances of survival and neurological recovery in patients who are successfully resuscitated from cardiac arrest. Therefore, resuscitation following cardiac arrest was chosen as an Emergency Neurological Life Support protocol. Key aspects of successful early post-arrest management include: prevention of secondary brain injury; identification of treatable causes of arrest in need of emergent intervention; and, delayed neurological prognostication...
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28913499/perioperative-hyperoxia-perhaps-a-malady-in-disguise
#8
REVIEW
Yalim Dikmen, Aybike Onur
Oxygen is an element, which is used liberally during several medical procedures. The use of oxygen during perioperative care is a controversial issue. Anesthesiologists use oxygen to prevent hypoxemia during surgical procedures, but the effects of its liberal use can be harmful. Another argument for using high oxygen concentrations is to prevent surgical site infections by increasing oxygen levels at the incision site. Although inconclusive, literature concerning the use of high oxygen concentrations during anesthesia show that this approach may cause hemodynamic changes, altered microcirculation and increased oxidative stress...
April 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28912359/left-ventricular-strain-rate-is-reduced-during-voluntary-apnea-in-healthy-humans
#9
Joshua R Smith, Shelbi L Sutterfield, Dryden R Baumfalk, Kaylin D Didier, Shane M Hammer, Jacob Troy Caldwell, Carl J Ade
During an apneic event, sympathetic nerve activity increases resulting in subsequent increases in left ventricular afterload and myocardial work. It is unknown how cardiac mechanics are acutely impacted by the increased myocardial work during an apneic event. 10 healthy individuals (23 ± 3 yrs) performed multiple voluntary end-expiratory apnea (VEEA) maneuvers exposed to room air, while a subset (n=7) completed multiple VEEA exposed to hyperoxic air (100% FiO2). Beat-by-beat blood pressure, heart rate and stroke volume were measured continuously...
September 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28899910/human-hypoxic-pulmonary-vasoconstriction-is-unaltered-by-8%C3%A2-h-of-preceding-isocapnic-hyperoxia
#10
Hung-Yuan Cheng, Quentin P P Croft, Matthew C Frise, Nick P Talbot, Nayia Petousi, Peter A Robbins, Keith L Dorrington
Exposure to sustained hypoxia of 8 h duration increases the sensitivity of the pulmonary vasculature to acute hypoxia, but it is not known whether exposure to sustained hyperoxia affects human pulmonary vascular control. We hypothesized that exposure to 8 h of hyperoxia would diminish the hypoxic pulmonary vasoconstriction (HPV) that occurs in response to a brief exposure to hypoxia. Eleven healthy volunteers were studied in a crossover protocol with randomization of order. Each volunteer was exposed to acute isocapnic hypoxia (end-tidal PO2 = 50 mmHg for 10 min) before and after 8 h of hyperoxia (end-tidal PO2 = 420 mmHg) or euoxia (end-tidal PO2 = 100 mmHg)...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28886148/balancing-anti-inflammatory-and-anti-oxidant-responses-in-murine-bone-marrow-derived-macrophages
#11
Christopher R Nitkin, Tracey L Bonfield
RATIONALE: The underlying pathophysiology of bronchopulmonary dysplasia includes a macrophage-mediated host response orchestrated by anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARγ) and anti-oxidant nuclear factor (erythroid-derived 2)-like 2 (Nrf2). These have not yet been studied in combination. This study tested the hypothesis that combined inflammatory and oxidative stressors would interact and change PPARγ- and Nrf2-regulated gene expression and antioxidant capacity...
2017: PloS One
https://www.readbyqxmd.com/read/28880206/comparative-response-of-brain-to-chronic-hypoxia-and-hyperoxia
#12
REVIEW
Laura Terraneo, Michele Samaja
Two antithetic terms, hypoxia and hyperoxia, i.e., insufficient and excess oxygen availability with respect to needs, are thought to trigger opposite responses in cells and tissues. This review aims at summarizing the molecular and cellular mechanisms underlying hypoxia and hyperoxia in brain and cerebral tissue, a context that may prove to be useful for characterizing not only several clinically relevant aspects, but also aspects related to the evolution of oxygen transport and use by the tissues. While the response to acute hypoxia/hyperoxia presumably recruits only a minor portion of the potentially involved cell machinery, focusing into chronic conditions, instead, enables to take into consideration a wider range of potential responses to oxygen-linked stress, spanning from metabolic to genic...
September 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28874201/tetrahydrobiopterin-bh4-deficiency-is-associated-with-augmented-inflammation-and-microvascular-degeneration-in-the-retina
#13
José Carlos Rivera, Baraa Noueihed, Ankush Madaan, Isabelle Lahaie, Jingyi Pan, Jaques Belik, Sylvain Chemtob
BACKGROUND: Tetrahydrobiopterin (BH4) is an essential cofactor in multiple metabolic processes and plays an essential role in maintaining the inflammatory and neurovascular homeostasis. In this study, we have investigated the deleterious effects of BH4 deficiency on retinal vasculature during development. METHODS: hph-1 mice, which display deficiency in BH4 synthesis, were used to characterize the inflammatory effects and the integrity of retinal microvasculature...
September 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28873369/dexmedetomidine-alleviates-hyperoxia-induced-acute-lung-injury-via-inhibiting-nlrp3-inflammasome-activation
#14
Qiuyue Zhang, Di Wu, Yang Yang, Tingting Liu, Hongyu Liu
BACKGROUND/AIMS: Dexmedetomidine (Dex), a specific agonist of α2-adrenoceptor, has been reported to have extensive pharmacological effects. In this study, we focused on the protective effect of Dex on hyperoxia-induced acute lung injury and further explored its possible molecular mechanisms. METHODS: The model of hyperoxia-induced acute lung injury was established by continuous inhalation of oxygen (FiO2= 0.90) for 7 d in neonatal rats in vivo. The in vitro experiments were carried out in LPS/ATP or hyperoxia-treated RAW264...
August 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28865296/peroxiredoxin-6-phospholipid-hydroperoxidase-activity-in-the-repair-of-peroxidized-cell-membranes
#15
Aron B Fisher, Jose P Vasquez-Medina, Chandra Dodia, Elena M Sorokina, Jian-Qin Tao, Sheldon I Feinstein
Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to the pre-exposure state. We have shown that resolution of lipid peroxidation is greatly delayed in lungs or cells that are null for peroxiredoxin 6 (Prdx6) and that both the phospholipase A2 and the GSH peroxidase activities of Prdx6 are required for a maximal rate of recovery. Like other peroxiredoxins, Prdx6 can reduce H2O2 and short chain hydroperoxides, but in addition can directly reduce phospholipid hydroperoxides...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28862598/-correction-of-the-oxidant-antioxidant-balance-in-lungs-during-hyperoxia-by-liposomal-alpha-tocopherol-and-retinoids-in-the-experiment
#16
I L Kotovich, Zh A Rutkovskaya, A D Tahanovich
The influence of inhaled liposomes, containing dipalmitoyl phosphatidylcholine and a-tocopherol, and liposomes containing dipalmitoyl phosphatidylcholine, retinol and retinoic acid, on parameters of the oxidantantioxidant system in lungs of newborn guinea pigs exposed to hyperoxia during 3 and 14 days has been studied. Administration of both types of liposomes under conditions of prolonged hyperoxia (14 days) results in normalization of glutathione peroxidase activity and prevents elevation of the levels of lipid and protein peroxidation products in bronchoalveolar lavage fluid...
July 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28861146/therapeutic-effects-of-fibroblast-growth-factor-10-on-hyperoxia-induced-bronchopulmonary-dysplasia-in-neonatal-mice
#17
Tao Han, Ming Chi, Yan Wang, Yabo Mei, Qiuping Li, Mengnan Yu, Qianqian Ma, Yuhan Chen, Zhichun Feng
The survival rate of preterm neonates increases significantly with the development of neonatal care and comprehensive treatment, but more and more high-risk preterm neonates suffer from bronchopulmonary dysplasia (BPD). Currently, there is no effective treatment for BPD, thus it is still a major cause of disability and mortality in neonates. Thus, it is imperative to investigate the pathogenesis and treatment of BPD in depth. Fibroblast growth factor-10 (FGF-10) is a paracrine growth factor binding its receptors (FGFR1 and FGFR2) to regulate a lot of biological processes...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28853608/mesenchymal-stromal-cell-exosomes-ameliorate-experimental-bronchopulmonary-dysplasia-and-restore-lung-function-through-macrophage-immunomodulation
#18
Gareth R Willis, Angeles Fernandez-Gonzalez, Jamie Anastas, Sally H Vitali, Xianlan Liu, Maria Ericsson, April Kwong, S Alex Mitsialis, Stella Kourembanas
RATIONALE: Mesenchymal stem/stromal cell (MSC) therapies have shown promise in preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary dysplasia (BPD). We have reported that the therapeutic capacity of MSCs is comprised in their secretome, and demonstrated that the therapeutic vectors are exosomes produced by MSCs (MSC-exos). OBJECTIVE: To assess efficacy of MSC-exo treatment in a pre-clinical model of BPD and to investigate mechanisms underlying MSC-exo therapeutic action...
August 30, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28851267/expression-profiling-of-genes-regulated-by-sphingosine-kinase1-signaling-in-a-murine-model-of-hyperoxia-induced-neonatal-bronchopulmonary-dysplasia
#19
Viswanathan Natarajan, Alison W Ha, Yangbasai Dong, Narsa M Reddy, David L Ebenezer, Prasad Kanteti, Sekhar P Reddy, J Usha Raj, Zhengdeng Lei, Mark Maienschein-Cline, Zarema Arbieva, Anantha Harijith
BACKGROUND: Sphingosine- 1-Phosphate (S1P) is a bioactive lipid and an intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to five related cell surface G-protein-coupled receptors (S1P1-5). S1P levels are tightly regulated by its synthesis catalyzed by sphingosine kinases (SphKs) 1 & 2 and catabolism by S1P phosphatases, lipid phosphate phosphatases and S1P lyase. We previously reported that knock down of SphK1 (Sphk1 (-/-) ) in a neonatal mouse BPD model conferred significant protection against hyperoxia induced lung injury...
August 29, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28839101/hyperoxia-treatment-of-trek-1-trek-2-traak-deficient-mice-is-associated-with-a-reduction-in-surfactant-proteins
#20
Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean L Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M Waters
We previously proposed a role for the 2-pore domain potassium (K2P) channel TREK-1 in hyperoxia (HO)-induced lung injury. To determine whether redundancy between the 3 TREK isoforms (TREK-1, TREK-2, TRAAK) could protect from HO-induced injury, we now examined the effect of deletion of all 3 TREK isoforms in a clinically relevant scenario of prolonged HO exposure and mechanical ventilation (MV). We exposed WT and TREK-1/TREK-2/TRAAK-deficient (triple ko) mice to either room air, 72 hours HO, MV (high and low tidal volume), or a combination of HO+MV, and measured quasi-static lung compliance, BAL protein concentration, histologic lung injury scores (LIS), cellular apoptosis, and cytokine levels...
August 24, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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